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| Product | Description | |
|---|---|---|
| Folate-Doxorubicin Liposome (PEGylated) | This formulation is Doxorubicin Liposome (PEGylated) with the folate. Folate binding protein (FBP) is an endogenous protein, which shows a very high affinity for folate. An antibody can be tagged by FBP and an immunoliposome can be formed by non-covalent and high affinity interaction between FBP and folate lipid on the surface of the liposome. Group: Drug-loaded liposome. Categories: liposomes, niosomes, ethosomes, and transfersomes. |  |
| Folate-PEG2000-COOH | Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. in addition to pegylation, activated peg derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. Group: Poly(ethylene glycol) and poly(ethylene oxide). Molecular formula: average Mn 2000. |  |
| Folate-PEG3-alkyne | CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction. Group: Terminal alkynes. Alternative Names: Folate-PEG3-propargyl. CAS No. 1245285-73-7. Molecular formula: C28H34N8O8. Mole weight: 610.6. IUPACName: (2S) -2-[[4-[ (2-Amino-4-oxo-3H-pteridin-6-yl) methylamino]benzoyl]amino]-5-oxo-5-[2-[2- (2-prop-2-ynoxyethoxy) ethoxy]ethylamino]pentanoic acid. Canonical SMILES: C#CCOCCOCCOCCNC (=O)CC[C@@H] (C (=O)O)NC (=O)C1=CC=C (C=C1)NCC2=CN=C3C (=N2)C (=O)NC (=N3)N. Density: 1.41±0.1 g/cm3(Predicted). Catalog: CCR1245285737. |  |
| Folate-PEG3-azide | CuAAC & SPAAC Click Reactions. Group: Azides. CAS No. 1313026-32-2. Molecular formula: C27H35N11O8. Mole weight: 641.64. Catalog: CCR1313026322. | |
| 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(Polyethylene glycol)-2000] (ammonium salt) | 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(Polyethylene glycol)-2000] (ammonium salt). Group: Polyethylene (pe). CAS No. 1236288-25-7. Product ID: azane; 5- [2- [2- [2- [2, 3-di (octadecanoyloxy) propoxy-hydroxyphosphoryl] oxyethylcarbamoyloxy] ethoxy] ethylamino] -2- [ [4- [ (2-imino-4-oxo-4aH-pteridin-6-yl) methylamino] benzoyl] amino] -5-oxopentanoic acid. Molecular formula: 6226.473g/mol. Mole weight: C287H558N11O127P. CCCCCCCCCCCCCCCCCC (=O)OCC (COP (=O) (O)OCCNC (=O)OCCOCCNC (=O)CCC (C (=O)O)NC (=O)C1=CC=C (C=C1)NCC2=NC3C (=O)NC (=N)N=C3N=C2)OC (=O)CCCCCCCCCCCCCCCCC. N. InChI= 1S / C65H108N9O16P. H3N / c1-3-5-7-9-11-13-15-17-19-21-23-25-27 -29-31-33-57 (76) 87-49-54 (90-58 (77) 34-32-30-28-26-24-22-20-18-16-14-12-1 0-8-6-4-2) 50-89-91 (83, 84) 88-44-42-68-65 (82) 86-46-45-85-43-41-67-56 (75) 40-39-55 (63 (80) 81) 72-61 (78) 51-35-37-52 (38-36-51) 69-47-53-48-70-60-59 (71-53) 62 (79) 74-64 (66) 73-60; / h35-38, 48, 54-55, 59, 69H, 3-34, 39-47, 49-50H2, 1-2H3, (H, 67, 75) (H, 68, 82) (H, 72, 78) (H, 80, 81) (H, 83, 84) ( H2, 66, 74, 79) ; 1H3. WXIKCKLNMQSVPC-UHFFFAOYSA-N. | |
| 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(Polyethylene glycol)-5000] (ammonium salt) | 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(Polyethylene glycol)-5000] (ammonium salt). Group: Polyethylene (pe). CAS No. 1236288-25-7. Product ID: azane; 5- [2- [2- [2- [2, 3-di (octadecanoyloxy) propoxy-hydroxyphosphoryl] oxyethylcarbamoyloxy] ethoxy] ethylamino] -2- [ [4- [ (2-imino-4-oxo-4aH-pteridin-6-yl) methylamino] benzoyl] amino] -5-oxopentanoic acid. Molecular formula: 6226.473g/mol. Mole weight: C287H558N11O127P. CCCCCCCCCCCCCCCCCC (=O)OCC (COP (=O) (O)OCCNC (=O)OCCOCCNC (=O)CCC (C (=O)O)NC (=O)C1=CC=C (C=C1)NCC2=NC3C (=O)NC (=N)N=C3N=C2)OC (=O)CCCCCCCCCCCCCCCCC. N. InChI= 1S / C65H108N9O16P. H3N / c1-3-5-7-9-11-13-15-17-19-21-23-25-27 -29-31-33-57 (76) 87-49-54 (90-58 (77) 34-32-30-28-26-24-22-20-18-16-14-12-1 0-8-6-4-2) 50-89-91 (83, 84) 88-44-42-68-65 (82) 86-46-45-85-43-41-67-56 (75) 40-39-55 (63 (80) 81) 72-61 (78) 51-35-37-52 (38-36-51) 69-47-53-48-70-60-59 (71-53) 62 (79) 74-64 (66) 73-60; / h35-38, 48, 54-55, 59, 69H, 3-34, 39-47, 49-50H2, 1-2H3, (H, 67, 75) (H, 68, 82) (H, 72, 78) (H, 80, 81) (H, 83, 84) ( H2, 66, 74, 79) ; 1H3. WXIKCKLNMQSVPC-UHFFFAOYSA-N. | |
| 16:0 Folate Cap PE | 16:0 Folate Cap PE. Group: Others. Purity: >99%. Mole weight: 1272.484. Stability: 1 Year. Storage: -20°C. Avanti Polar Lipids; lipid products; natural lipids; natural; synthetic lipid; synthetic; modified lipids; headgroup modified lipids; fatty acid modified lipids; singnal transduction; cell pathways; 16:0 Folate Cap PE; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-(6-((folate)amino)hexanoyl) (sodium salt). Cat No: NSMZ-053. |  |
| 5-formyltetrahydrofolate cyclo-ligase | This enzyme belongs to the family of ligases, specifically the cyclo-ligases, which form carbon-nitrogen bonds. This enzyme participates in one carbon pool by folate. Group: Enzymes. Synonyms: 5,10-methenyltetrahydrofolate synthetase; formyltetrahydrofolic cyclodehydrase; 5-formyltetrahydrofolate cyclodehydrase. Enzyme Commission Number: EC 6.3.3.2. CAS No. 37318-64-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5774; 5-formyltetrahydrofolate cyclo-ligase; EC 6.3.3.2; 37318-64-2; 5,10-methenyltetrahydrofolate synthetase; formyltetrahydrofolic cyclodehydrase; 5-formyltetrahydrofolate cyclodehydrase. Cat No: EXWM-5774. | |
| 5-Methyltetrahydrofolate acid | 5-Methyltetrahydrofolate acid. Group: Biochemicals. Alternative Names: Methyl folate. Grades: Highly Purified. CAS No. 134-35-0. Pack Sizes: 1g, 5g, 10g, 25g, 50g. Molecular Formula: C20H22N7O6. US Biological Life Sciences. |  Worldwide |
| Calcium Levomefolate | The calcium salt of L-5-methyltetrahydrofolic acid which belongs to the group of folate vitamins (Vitamin B9, Folacin). It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements. Synonyms: Levomefolate calcium. Grades: >98%. CAS No. 151533-22-1. Molecular formula: C20H23N7O6.Ca. Mole weight: 499.53. |  |
| dihydrofolate reductase | The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. Group: Enzymes. Synonyms: tetrahydrofolate dehydrogenase; DHFR; pteridine reductase:dihydrofolate reductase; dihydrofolate reductase:thymidylate synthase; thymidylate synthetase-dihydrofolate reductase; folic acid reductase; folic reductase; dihydrofolic acid reductase; dihydrofolic reductase; 7,8-dihydrofolate reductase; NADPH-dihydrofolate reductase. Enzyme Commission Number: EC 1.5.1.3. CAS No. 9002-3-3. Dihydrofolate Reductase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1511; dihydrofolate reductase; EC 1.5.1.3; 9002-03-3; tetrahydrofolate dehydrogenase; DHFR; pteridine reductase:dihydrofolate reductase; dihydrofolate reductase:thymidylate synthase; thymidylate synthetase-dihydrofolate reductase; folic acid reductase; folic reductase; dihydrofolic acid reductase; dihydrofolic reductase; 7,8-dihydrofolate reductase; NADPH-dihydrofolate reductase. Cat No: EXWM-1511. | |
| dihydrofolate synthase | In some bacteria, a single protein catalyses both this activity and that of EC 6.3.2.17, tetrahydrofolate synthase, the combined activity of which leads to the formation of the coenzyme polyglutamated tetrahydropteroate (H4PteGlun), i.e. various tetrahydrofolates. In contrast, the activities are located on separate proteins in most eukaryotes studied to date. This enzyme is reponsible for attaching the first glutamate residue to dihydropteroate to form dihydrofolate and is present only in those organisms that have the ability to synthesize tetrahydrofolate de novo, e.g. plants, most bacteria, fungi and protozoa. Group: Enzymes. Synonyms: dihydrofolate synthetase; 7,8-dihydrofolate synthetase; H2-folate synthetase; 7,8-dihydropteroate:L-glutamate ligase (ADP); dihydropteroate:L-glutamate ligase (ADP-forming); DHFS. Enzyme Commission Number: EC 6.3.2.12. CAS No. 37318-62-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5733; dihydrofolate synthase; EC 6.3.2.12; 37318-62-0; dihydrofolate synthetase; 7,8-dihydrofolate synthetase; H2-folate synthetase; 7,8-dihydropteroate:L-glutamate ligase (ADP); dihydropteroate:L-glutamate ligase (ADP-forming); DHFS. Cat No: EXWM-5733. | |
| DSPE-PEG(5000) Folate | PEG Lipids. Alternative Names: 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-5000] (ammonium salt); 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[carbonyl-amino(polyethylene glycol)-5000-N'-(folyl)] (ammonium salt). CAS No. 1236288-25-7. Molecular formula: C287H558N11O127P. Mole weight: 6226.55. Appearance: Powder. IUPACName: azane; 5- [2- [2- [2- [2, 3-di (octadecanoyloxy) propoxy-hydroxyphosphoryl] oxyethylcarbamoyloxy] ethoxy] ethylamino] -2- [ [4- [ (2-imino-4-oxo-4aH-pteridin-6-yl) methylamino] benzoyl] amino] -5-oxopentanoic acid. Canonical SMILES: CCCCCCCCCCCCCCCCCC (=O)OCC (COP (=O) (O)OCCNC (=O)OCCOCCNC (=O)CCC (C (=O)O)NC (=O)C1=CC=C (C=C1)NCC2=NC3C (=O)NC (=N)N=C3N=C2)OC (=O)CCCCCCCCCCCCCCCCC. N. Catalog: ACM1236288257-1. | |
| formyltetrahydrofolate deformylase | This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is 10-formyltetrahydrofolate amidohydrolase. This enzyme participates in glyoxylate and dicarboxylate metabolism and one carbon pool by folate. Group: Enzymes. Enzyme Commission Number: EC 3.5.1.10. CAS No. 9025-8-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4378; formyltetrahydrofolate deformylase; EC 3.5.1.10; 9025-08-5. Cat No: EXWM-4378. | |
| formyltetrahydrofolate dehydrogenase | This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 10-formyltetrahydrofolate:NADP+ oxidoreductase. Other names in common use include 10-formyl tetrahydrofolate:NADP oxidoreductase, 10-formyl-H2PtGlu:NADP oxidoreductase, 10-formyl-H4folate dehydrogenase, N10-formyltetrahydrofolate dehydrogenase, and 10-formyltetrahydrofolate dehydrogenase. This enzyme participates in one carbon pool by folate. Group: Enzymes. Synonyms: 10-formyl tetrahydrofolate:NADP oxidoreductase; 10-formyl-H2PtGlu:NADP oxidoreductase 10-formyl-H4folate dehydrogenase; N10-formyltetrahydrofolate dehydrogenase 10-formyltetrahydrofolate dehydrogenase. Enzyme Commission Number: EC 1.5.1.6. CAS No. 37256-25-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1533; formyltetrahydrofolate dehydrogenase; EC 1.5.1.6; 37256-25-0; 10-formyl tetrahydrofolate:NADP oxidoreductase; 10-formyl-H2PtGlu:NADP oxidoreductase 10-formyl-H4folate dehydrogenase; N10-formyltetrahydrofolate dehydrogenase 10-formyltetrahydrofolate dehydrogenase. Cat No: EXWM-1533. | |
| Levomefolate Calcium (5-Methyltetrahydrofolic Acid Calcium Salt ) | The calcium salt of L-5-methyltetrahydrofolic acid which belongs to the group of folate vitamins (Vitamin B9, Folacin). It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements. Group: Biochemicals. Alternative Names: N- [4- [ [ [ (6S) -2-Amino-3, 4, 5, 6, 7, 8-hexahydro-5-methyl-4-oxo-6-pteridinyl] methyl] amino] benzoyl] -L-glutamic Acid Calcium SaltN-[4-[[ (2-Amino-1, 4, 5, 6, 7, 8-hexahydro-5-methyl-4-oxo-6-pteridinyl) methyl]amino]benzoyl]-L-glutamic Acid Calcium Salt; Bodyfolin; LMCA; Metafolin; Nutrifolin. Grades: Highly Purified. CAS No. 151533-22-1. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| methylenetetrahydrofolate dehydrogenase (NAD+) | This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase. This enzyme is also called methylenetetrahydrofolate dehydrogenase (NAD+). This enzyme participates in one carbon pool by folate. Group: Enzymes. Synonyms: methylenetetrahydrofolate dehydrogenase (NAD+). Enzyme Commission Number: EC 1.5.1.15. CAS No. 82062-90-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1496; methylenetetrahydrofolate dehydrogenase (NAD+); EC 1.5.1.15; 82062-90-6; methylenetetrahydrofolate dehydrogenase (NAD+). Cat No: EXWM-1496. | |
| methylenetetrahydrofolate-tRNA-(uracil54-C5)-methyltransferase (FADH2-oxidizing) | Up to 25% of the bases in mature tRNA are post-translationally modified or hypermodified. One almost universal post-translational modification is the conversion of U54 into ribothymidine in the TψC loop, and this modification is found in most species studied to date. Unlike this enzyme, which uses 5,10-methylenetetrahydrofolate and FADH2 to supply the atoms for methylation of U54, EC 2.1.1.35, tRNA (uracil54-C5)-methyltransferase, uses S-adenosyl-L-methionine. Group: Enzymes. Synonyms: folate-dependent ribothymidyl synthase; methylenetetrahydrofolate-transfer ribonucleate uracil 5-methyltransferase; 5,10-methylenetetrahydrofolate:tRNA-UψC (uracil-5-)-methyl-tran. Enzyme Commission Number: EC 2.1.1.74. CAS No. 56831-74-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1975; methylenetetrahydrofolate-tRNA-(uracil54-C5)-methyltransferase (FADH2-oxidizing); EC 2.1.1.74; 56831-74-4; folate-dependent ribothymidyl synthase; methylenetetrahydrofolate-transfer ribonucleate uracil 5-methyltransferase; 5,10-methylenetetrahydrofolate:tRNA-UψC (uracil-5-)-methyl-transferase; 5,10-methylenetetrahydrofolate:tRNA (uracil-5-)-methyl-transferase; TrmFO; folate/FAD-dependent tRNA T54 methyltransferase. Cat No: EXWM-1975. | |
| Methyl folate | Methyl folate is an active metabolite of folic acid. It acts as a methyl-group donor involved in the conversion of homocysteine to methionine in conjunction with vitamin B12. Vitamin supplement in health care products. Uses: Ingredient of health care products. Synonyms: Prefolic A; 5-Methyltetrahydrofolate; N-methyltetrahydrofolic acid; 5-Methyltetrahydropteroylglutamate. Grades: 95%. CAS No. 134-35-0. Molecular formula: C20H25N7O6. Mole weight: 459.46. | |
| Stearic acid PEG Folate | Stearic acid is an 18 carbon saturated fatty acid lipid with excellent hydrophobicity. PEG modified stearic acid is an excellent amphilphilic polymer with both hydrophilicity and hydrophobility. Pegylated lipids are excellent liposome formation materials that can be used for drug delivery, gene transfection and vaccine delivery as well. These materials can also be used for targeted drug delivery by modifying their surfaces with targeting ligands such as antibodies, peptides. Product ID: PE-0025. Mole weight: 3400 Da. Category: Emulsifier Excipients. Product Keywords: Pharmaceutical Excipients; Liquid Dosage Form; Semi-solid Dosage Form; Suppository Bases;Micro-drug Delivery Systems;Emulsifier Excipients; Stearic acid PEG Folate; PE-0025. Appearance: Solid powder. Solubility: Soluble in regular aqeous solution as well as most organic solvents. Storage: Store at -20°C, dessiccate. Protect from light. Avoid frequent thaw and freeze. |  |
| tetrahydrofolate synthase | In some bacteria, a single protein catalyses both this activity and that of EC 6.3.2.12, dihydrofolate synthase, the combined activity of which leads to the formation of the coenzyme polyglutamated tetrahydropteroate (H4PteGlun), i.e. various tetrahydrofolates (H4folate). In contrast, the activities are located on separate proteins in most eukaryotes studied to date. In Arabidopsis thaliana, this enzyme is present as distinct isoforms in the mitochondria, the cytosol and the chloroplast. Each isoform is encoded by a separate gene, a situation that is unique among eukaryotes. As the affinity of folate-dependent enzymes increases markedly with the number of glutamic residues, the ...glutamate synthetase; FPGS; tetrahydrofolylpolyglutamate synthase; tetrahydrofolate:L-glutamate γ-ligase (ADP-forming); tetrahydropteroyl-[γ-Glu]n:L-glutamate γ-ligase (ADP-forming). Enzyme Commission Number: EC 6.3.2.17. CAS No. 63363-84-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5737; tetrahydrofolate synthase; EC 6.3.2.17; 63363-84-8; folylpolyglutamate synthase; folate polyglutamate synthetase; formyltetrahydropteroyldiglutamate synthetase; N10-formyltetrahydropteroyldiglutamate synthetase; folylpoly-γ-glutamate synthase; folylpolyglutamyl synthetase; folylpol | |
| trimethylsulfonium-tetrahydrofolate N-methyltransferase | This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is trimethylsulfonium:tetrahydrofolate N-methyltransferase. This enzyme is also called trimethylsulfonium-tetrahydrofolate methyltransferase. This enzyme participates in one carbon pool by folate. Group: Enzymes. Synonyms: trimethylsulfonium-tetrahydrofolate methyltransferase. Enzyme Commission Number: EC 2.1.1.19. CAS No. 37256-92-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1789; trimethylsulfonium-tetrahydrofolate N-methyltransferase; EC 2.1.1.19; 37256-92-1; trimethylsulfonium-tetrahydrofolate methyltransferase. Cat No: EXWM-1789. | |
| 10-Formyl Folic Acid | A Folic acid derivative (or folate) found in daily dietary intake that is often used in cancer risk correlation studies. Group: Biochemicals. Alternative Names: N- [4- [ [ (2-Amino-3, 4-dihydro-4-oxo-6-pteridinyl) methyl] formylamino] benzoyl] -L-glutamic Acid; 10-Formylpteroylglutamic Acid; N10-Formylfolic Acid; N- [p- [N- [ (2-Amino-4-hydroxy-6-pteridinyl) methyl] formamido] benzoyl] -glutamic Acid. CAS No. 134-05-4. Pack Sizes: 50mg, 100mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| 1-Deoxy-4-O- β-D-glucopyranosyl-1-[4-[(2s)-2-(pentane-1,5-dioic acid) amino]phenylimino]-D-glucitol | 1-Deoxy-4-O- β-D-glucopyranosyl-1-[4-[(2s)-2-(pentane-1,5-dioic acid) amino]phenylimino]-D-glucitol is an impurity of Folic Acid (F680300) which is a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, and also act as a cofactor in biological reactions involving folate. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 50mg. Molecular Formula: C23H34N2O14, Molecular Weight: 562.52. US Biological Life Sciences. | Worldwide |
| 1- ( (Dimethylamino) (dimethyliminio) methoxy) -2, 5-dioxopyrrolidine-3-sulfonate Sodium Salt Hexafluorophosphate | 1- ( (Dimethylamino) (dimethyliminio) methoxy) -2, 5-dioxopyrrolidine-3-sulfonate Sodium Salt Hexafluorophosphate is an intermediate in the synthesis of Folic Acid Sulfosuccinimidyl Ester Sodium Salt. Folic Acid Sulfosuccinimidyl Ester Sodium Salt is a derivative of Folic Acid, a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate. Cross linking reagent. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 25mg. Molecular Formula: C9H15N3NaO6S+; PF6-. US Biological Life Sciences. | Worldwide |
| 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase | The enzyme participates in a folate biosynthesis pathway in Chlamydia. Group: Enzymes. Enzyme Commission Number: EC 4.2.1.160. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5001; 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase; EC 4.2.1.160. Cat No: EXWM-5001. | |
| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase | Binds 2 Mg2+ ions that are essential for activity. The enzyme participates in the biosynthetic pathways for folate (in bacteria, plants and fungi) and methanopterin (in archaea). The enzyme exists in varying types of multifunctional proteins in different organisms. The enzyme from the bacterium Streptococcus pneumoniae also harbours the activity of EC 4.1.2.25, dihydroneopterin aldolase, the enzyme from the plant Arabidopsis thaliana harbours the activity of EC 2.5.1.15, dihydropteroate synthase, while the enzyme from yeast Saccharomyces cerevisiae is trifunctional with both of the two above mentioned activities. Group: Enzymes. Synonyms: 2-amino-4-hydroxy-6-hydroxymethyldi. Enzyme Commission Number: EC 2.7.6.3. CAS No. 37278-23-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3222; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; EC 2.7.6.3; 37278-23-2; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; H2-pteridine-CH2OH pyrophosphokinase; 7,8-dihydroxymethylpterin-pyrophosphokinase; HPPK; 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase; hydroxymethyldihydropteridine pyrophosphokinase; ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase. Cat No: EXWM-3222. | |
| 4-(2,4-Diamino-6-ethyl-5-pyrimidinyl)-phenol | Used in the synthesis of anti-folate antimalarial agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 1397693-25-2. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 4-Aminobenzoic acid-13C6 | 4-Aminobenzoic acid-13C6 is the 13C-labeled 4-Aminobenzoic acid. 4-Aminobenzoic acid is an intermediate in the synthesis of folate by bacteria, plants, and fungi. Group: Isotope-labeled synthetic intermediates. Alternative Names: PABA-13C6; Vitamin Bx-13C6; Vitamin H1-13C6; p-Aminobenzoic acid-13C6. CAS No. 161406-19-5. Molecular formula: C13C6H7NO2. Mole weight: 143.09. Canonical SMILES: OC ([13C]1=[13CH][13CH]=[13C] ([13CH]=[13CH]1)N)=O. Catalog: ACM161406195. | |
| 5-Carboxypentyl triphenylphosphonium bromide | (5-Carboxypentyl)(triphenyl)phosphonium bromide is used in medicine and as pharmaceutical intermediate. It is also employed as catalyst. Reactant for: Preparation of inhibitor of protein tyrosine phosphatase 1B for treatment of diabetes and obesity. Synthesis of folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity. Preparation of peptide nucleic acids (PNA) with high specific activity. Synthesis of roseophilin via Wittig/aldol methodology. Group: Organic phosphine compounds. Alternative Names: (5-Carboxypentyl)(Triphenyl)Phosphonium Bromide. CAS No. 50889-29-7. Molecular formula: C24H26BrO2P. Mole weight: 457.35. Appearance: Solid. Purity: 0.98. IUPACName: 5-carboxypentyl(triphenyl)phosphanium; bromide. Canonical SMILES: C1=CC=C (C=C1)[P+] (CCCCCC (=O)O) (C2=CC=CC=C2)C3=CC=CC=C3. [Br-]. Catalog: ACM50889297-3. | |
| 5-Methyltetrahydrofolic Acid Calcium Salt Hydrate | 5-Methyltetrahydrofolic Acid Calcium Salt Hydrate is a metabolite of Folic acid, which is used to treat anemia caused by folate deficiency. Synonyms: N-[4-[[(2-Amino-3,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid Calcium Hydrate; N-Methyltetrahydrofolate Calcium Hydrate; N5-Methyltetrahydrofolate Calcium Hydrate; N5-Methyltetrahydropteroylglutamate Calcium Hydrate; Prefolic A. Grades: 95%. Molecular formula: C20H23CaN7O6.xH2O. Mole weight: 497.52 (anhydrous). | |
| 5-Methyltetrahydrofolic acid Disodium Salt | Folate derivative and the sodium salt form of N-Methyltetrahydrofolic acid. Group: Biochemicals. Alternative Names: 5-Methyl-THF; 5-Methyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid disodium salt; N-[4-[[ (2-Amino-1, 4, 5, 6, 7, 8-hexahydro-5-methyl-4-oxo-6-pteridinyl) methyl]amino]benzoyl]-DL- glutamic acid disodium salt; Glutamic acid, N-[4-[[ (2-amino-3, 4, 5, 6, 7, 8-hexahydro-5-methyl-4-oxo-6-pteridinyl) methyl]amino]benzoyl]-, sodium salt (1:2); DL-Glutamic acid, N-[4-[[ (2-amino-1, 4, 5, 6, 7, 8-hexahydro-5-methyl-4-oxo-6-pteridinyl) methyl]amino]benzoyl]-, disodium salt; Glutamic acid, N-[4-[[ (2-amino-1, 4, 5, 6, 7, 8-hexahydro-5-methyl-4-oxo-6-pteridinyl) methyl]amino]benzoyl]-, disodium salt (9CI). Grades: Highly Purified. CAS No. 68792-52-9. Pack Sizes: 5mg, 10mg, 25mg, 50mg. Molecular Formula: C??H??N?Na?O?, Molecular Weight: 503.42. US Biological Life Sciences. | Worldwide |
| (6S)-Tetrahydrofolic acid | (6S)-Tetrahydrofolic acid is 1000-fold more active than the (6R) form at promoting the binding of fluorodeoxyuridylate to thymidylate synthase and 600-fold more active as a growth factor of P. cerevisiae. (6S)-Tetrahydrofolic acid also has a low affinity and high dissociation rate for folate-binding protein [1]. Uses: Scientific research. Group: Natural products. Alternative Names: (6S)-5,6,7,8-Tetrahydrofolic acid. CAS No. 71963-69-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-14520A. |  |
| 7-Hydro-8-methylpteroylglutamyl-glutamic acid | 7-Hydro-8-methylpteroylglutamyl-glutamic acid is an antifolate produced by actinomycete SK-2049. It only has the activity against Enterococcus faecium and has no effect on other bacteria and fungi. Thymidine and folate-related compounds can counteract its activity. Synonyms: 7-Hydro-8-methylpteroylglutamyl-glutamic acid; N-(N-(4-(((2-Amino-1,4,7,8-tetrahydro-8-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-gamma-glutamyl)-L-glutamic acid; L-Glutamic acid, N-(N-(4-(((2-amino-1,4,7,8-tetrahydro-8-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-gamma-glutamyl)-. CAS No. 108402-49-9. Molecular formula: C25H30N8O9. Mole weight: 586.55. | |
| Acetylpyrazine | Acetylpyrazine (2-Acetylpyrazine) is used to form many polycyclic compounds, as useful structures in pharmaceuticals and perfumes. Acetylpyrazine is a component of the folates (vitamin B compounds) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2-Acetylpyrazine. CAS No. 22047-25-2. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-W007692. | |
| aminodeoxychorismate lyase | A pyridoxal-phosphate protein. Forms part of the folate biosynthesis pathway. Acts on 4-amino-4-deoxychorismate, the product of EC 2.6.1.85, aminodeoxychorismate synthase, to form p-aminobenzoate. Group: Enzymes. Synonyms: enzyme X; 4-amino-4-deoxychorismate lyase; 4-amino-4-deoxychorismate pyruvate-lyase. Enzyme Commission Number: EC 4.1.3.38. CAS No. 132264-33-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4914; aminodeoxychorismate lyase; EC 4.1.3.38; 132264-33-6; enzyme X; 4-amino-4-deoxychorismate lyase; 4-amino-4-deoxychorismate pyruvate-lyase. Cat No: EXWM-4914. | |
| ANX-510 | ANX-510 is a folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the fluorouracil metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP) to its target enzyme, thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituent of DNA, and tumor cell death. Synonyms: 5,10-Methylenetetrahydrofolic acid; 5,10-Methylene-tetrahydrofolate; Tetrahydromethylenefolate; N-{4-[3-amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]benzoyl}-L-glutamic acid. CAS No. 3432-99-3. Molecular formula: C20H23N7O6. Mole weight: 457.44. | |
| Beetroot Powder | Beet root powder is an excellent source of folate and a good source of manganese, and contains betaines which may function to reduce the concentration of homocysteine, a homolog of the naturally occurring amino acid cysteine. Beetroot powder is rich in nutrients, offers various health benefits. Apart from the health benefits, Beet root powder is found to be used as food colorants and as a traditional home remedy. The following are some of the health benefits of beetroot. Beetroot powder benefits for skin includes its cleansing action, which helps in eliminating toxins from the body. Group: Others. Beetroot Powder; Beta Vulgaris. Cat No: EXTC-103. | |
| BGC-638 | BGC-638, an analogue of BGC-945, is a thymidylate synthase inhibitor specifically transported into α-folate receptor (α-FR)-overexpressing tumors. Synonyms: BGC 638; BGC638; CB300638; CB-300638; D-Glutamic acid, N-(4-(2-propyn-1-yl((6S)-4,6,7,8-tetrahydro-2-methyl-4-oxo-3H-cyclopenta(g)quinazolin-6-yl)amino)benzoyl)-L-gamma-glutamyl-. CAS No. 416852-27-2. Molecular formula: C32H33N5O9. Mole weight: 631.64. | |
| BGC-945 | BGC 945 is a cyclopenta[g]quinazoline-based, thymidylate synthase inhibitor specifically transported into α-folate receptor (α-FR)-overexpressing tumors. BGC 945 has low affinity for the widely expressed reduced-folate carrier (RFC). BGC 945 selectively inhibits thymidylate synthase in α-FR-overexpressing tumors and should cause minimal toxicity to humans at therapeutic doses. Synonyms: Idetrexed; ONX-0801; N-[4-[2-Propynyl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-1H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-L-γ-glutamyl-D-glutamic acid; N-[4-[2-Propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-L-γ-glutamyl-D-glutamic acid; (R) -2- ( (S) -4-carboxy-4- (4- ( ( (S) -2- (hydroxymethyl) -4-oxo-4, 6, 7, 8-tetrahydro-3H-cyclopenta[g]quinazolin-6-yl) (prop-2-yn-1-yl) amino) benzamido) butanamido) pentanedioic acid. Grades: ≥95%. CAS No. 501332-69-0. Molecular formula: C32H33N5O10. Mole weight: 647.63. | |
| Biotin-PEG-PLGA | Biotin-PEG-PLGA. Synonyms: Folate-poly(ethylene glycol)-b-poly(lactide-co-glycolide). Product ID: MSMN-047. Category: Raw Materials. | |
| Broccoli Powder | Yesherb broccoli powder is made from fresh broccoli, a member of the cabbage family, and is closely related to cauliflower. Broccoli powder provides a range of tastes and textures, from soft and flowery (the floret) to fibrous and crunchy (the stem and stalk). Broccoli powder contains glucosinolates, phytochemicals which break down to compounds called indoles and isothiocyanates (such as sulphoraphane). Broccoli powder also contains the carotenoid, lutein, and excellent source of the vitamins K, C, and A, folate, fiber, and phosphorus, potassium, magnesium and vitamins B6 and E. Group: Others. Broccoli Powder; Brassica Oleracea L. Var. Botrytis L. Cat No: EXTC-110. | |
| Dapsone | Dapsone (4,4-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities [1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4,4-Diaminodiphenyl sulfone; DDS. CAS No. 80-08-0. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-B0688. | |
| deoxycytidylate 5-hydroxymethyltransferase | his enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. This enzyme participates in pyrimidine metabolism and one carbon pool by folate. Group: Enzymes. Synonyms: dCMP hydroxymethylase; d-cytidine 5'-monophosphate hydroxymethylase; deoxyCMP hydroxymethylase; deoxycytidylate hydroxymethylase; deoxycytidylic hydroxymethylase. Enzyme Commission Number: EC 2.1.2.8. CAS No. 9012-68-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2009; deoxycytidylate 5-hydroxymethyltransferase; EC 2.1.2.8; 9012-68-4; dCMP hydroxymethylase; d-cytidine 5'-monophosphate hydroxymethylase; deoxyCMP hydroxymethylase; deoxycytidylate hydroxymethylase; deoxycytidylic hydroxymethylase. Cat No: EXWM-2009. | |
| dihydroneopterin aldolase | The enzyme participates in folate (in bacteria, plants and fungi) and methanopterin (in archaea) biosynthesis. The enzymes from the bacterium Escherichia coli and the plant Arabidopsis thaliana also catalyse the epimerisation of the 2' hydroxy-group (EC 5.1.99.8, 7,8-dihydroneopterin epimerase). The enzyme from the bacterium Mycobacterium tuberculosis is trifunctional and also catalyses EC 5.1.99.8 and EC 1.13.11.81, 7,8-dihydroneopterin oxygenase. The enzyme from the yeast Saccharomyces cerevisiae also catalyses the two subsequent steps in the folate biosynthesis pathway - EC 2.7.6.3, 2-amino-4-hydroxy-6-(hydroxymethyl)dihydropteridine diphosphokinase, and EC 2.5.1.15, dihydropteroate synthase. Group: Enzymes. Synonyms: 7,8-dihydroneopterin aldolase; 2-amino-. Enzyme Commission Number: EC 4.1.2.25. CAS No. 37290-59-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4864; dihydroneopterin aldolase; EC 4.1.2.25; 37290-59-8; 7,8-dihydroneopterin aldolase; 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase; 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-forming); DHNA; mptD (gene name); folB (gene name). Cat No: EXWM-4864. | |
| dihydroneopterin triphosphate diphosphatase | The enzyme participates in a folate biosynthesis pathway, which is found in bacteria, fungi, and plants. Requires Mg2+. Group: Enzymes. Synonyms: folQ (gene name); nudB (gene name); NUDT1 (gene name); dihydroneopterin triphosphate pyrophosphohydrolase. Enzyme Commission Number: EC 3.6.1.67. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4640; dihydroneopterin triphosphate diphosphatase; EC 3.6.1.67; folQ (gene name); nudB (gene name); NUDT1 (gene name); dihydroneopterin triphosphate pyrophosphohydrolase. Cat No: EXWM-4640. | |
| dihydropteroate synthase | The enzyme participates in the biosynthetic pathways for folate (in bacteria, plants and fungi) and methanopterin (in archaea). The enzyme exists in varying types of multifunctional proteins in different organisms. The enzyme from the plant Arabidopsis thaliana also harbors the activity of EC 2.7.6.3, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase, while the enzyme from yeast Saccharomyces cerevisiae is trifunctional with the two above mentioned activities as well as EC 4.1.2.25, dihydroneopterin aldolase. Group: Enzymes. Synonyms: dihydropteroate pyrophosphorylase; DHPS; 7,8-dihydropteroate synthase; 7,8-dihydr. Enzyme Commission Number: EC 2.5.1.15. CAS No. 9055-61-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2751; dihydropteroate synthase; EC 2.5.1.15; 9055-61-2; dihydropteroate pyrophosphorylase; DHPS; 7,8-dihydropteroate synthase; 7,8-dihydropteroate synthetase; 7,8-dihydropteroic acid synthetase; dihydropteroate synthetase; dihydropteroic synthetase; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase; (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase. Cat No: EXWM-2751. | |
| DL-Homocysteine | DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain. DL-Homocysteine is correlated with Vitamin B12, renal functions and folate levels, affects the cross-sectional cognition indirectly through white matter microstructural integrity [2]. Uses: Scientific research. Group: Natural products. CAS No. 454-29-5. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-W040821. | |
| EC-17 | EC17, also known as Folate-FITC, is a conjugate consisting of fluorescein isothiocyanate (FITC) conjugated with folate with potential antineoplastic activity. Folate-FITC binds to folate receptors, which are overexpressed on the surfaces of many cancer cells including kidney and ovarian cancer cells. Once bound to the cancer cell through the folate moiety of the conjugate, curculating anti-fluorescein antibodies.may recognize and bind to the FITC moiety, resulting in antibody-dependent cellular cytotoxicity. Synonyms: EC17; EC 17; Folate-FITC; Folate-fluorescein conjugate. CAS No. 583037-91-6. Molecular formula: C42H36N10O10S. Mole weight: 872.87. | |
| Edatrexate | Edatrexate is a polyglutamatable folate antagonist analogue of methotrexate with antineoplastic activity. Edatrexate inhibits dihydrofolate reductase, thereby increasing cellular levels of polyglutamates, inhibiting thymidylate synthase and glycinamide ribonucleotide formyl transferase, impairing synthesis of purine nucleotides and amino acids, and resulting in tumor cell death. Edatrexate may overcome tumor resistance to methotrexate, which loses its activity after it is polyglutamated. Uses: Antineoplastic agents. Synonyms: 10-ethyl-deaza-aminopterin; 10-EDAM; 10 EDAM; 10EDAM; CGP-30694; CGP30694; CGP30694; D 03942; D-03942; D03942. CAS No. 80576-83-6. Molecular formula: C22H25N7O5. Mole weight: 467.49. | |
| Etarfolatide | A folate receptor-targeting radiopharmaceutical consisting of a folate-containing tetrapeptide chelator to which technetium Tc 99m is linked. The folate component of folate receptor-targeted technetium Tc99m-EC20 binds to folic acid receptors, which are frequently upregulated in many types of tumor cells and activated macrophages. An investigational drug in clinical trials for the treatment of breast neoplasms, non small cell lung cancer (NSCLC), and adenocarcinoma of the lung. CAS No. 479578-27-3. Molecular formula: C29H34N10O11S. Mole weight: 730.71. | |
| FAD synthetase | Requires Mg2+ and is highly specific for ATP as phosphate donor. The cofactors FMN and FAD participate in numerous processes in all organisms, including mitochondrial electron transport, photosynthesis, fatty-acid oxidation, and metabolism of vitamin B6, vitamin B12 and folates. While monofunctional FAD synthetase is found in eukaryotes and in some prokaryotes, most prokaryotes have a bifunctional enzyme that exhibits both this activity and that of EC 2.7.1.26, riboflavin kinase. Group: Enzymes. Synonyms: FAD pyrophosphorylase; riboflavin mononucleotide adenylyltransferase; adenosine triphosphate-riboflavin mononucleotide transadenylase; adenosine triphosphate-riboflavine mononucleotide transadenylase; riboflavin adenine dinucleotide pyrophosp. Enzyme Commission Number: EC 2.7.7.2. CAS No. 9026-37-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3234; FAD synthetase; EC 2.7.7.2; 9026-37-3; FAD pyrophosphorylase; riboflavin mononucleotide adenylyltransferase; adenosine triphosphate-riboflavin mononucleotide transadenylase; adenosine triphosphate-riboflavine mononucleotide transadenylase; riboflavin adenine dinucleotide pyrophosphorylase; riboflavine adenine dinucleotide adenylyltransferase; flavin adenine dinucleotide synthetase; FADS; FMN adenylyltransferase. Cat No: EXWM-3234. | |
| Farletuzumab | Farletuzumab (MORAb-003) is a potent folate receptor-alpha (FRα) inhibitor. Farletuzumab is a humanized monoclonal antibody with high affinity for FR&alpha. Farletuzumab possesses growth-inhibitory functions on cells overexpressing FR&alpha. Farletuzumab can be used in research of cancer [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: MORAb-003. CAS No. 896723-44-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99153. | |
| Farletuzumab ecteribulin | Farletuzumab ecteribulin (MORAb-202) is an antibody-drug conjugate (ADC), consisting of the humanized anti-human folate receptor alpha (FRA) antibody Farletuzumab (HY-P99153) conjugated via reduced interchain disulfide bonds to Mal-PEG2-Val-Cit-PAB-eribulin. Farletuzumab ecteribulin has a agent-to-antibody ratio of 4.0. Farletuzumab ecteribulin is highly cytotoxic to FRA-positive cells in vitro. Farletuzumab ecteribulin has potent antitumor activity. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: MORAb-202. CAS No. 2407465-18-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99612. | |
| Folic acid | Folic acid is a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, and it also acts as a cofactor in biological reactions involving folate. The combined use of enalapril and folic acid, compared with enalapril alone, significantly reduced the risk of first stroke. High folic acid intakes and MTHFR gene variations seem not to be associated with helping women to achieve pregnancy during or after fertility treatment. Uses: Hematopoietic vitamin. Synonyms: n-4-[(2-amido-4-oxo-1,4-dihydro-6-terene)methylamino]benzoyl-l-glutamic acid. Grades: >98%. CAS No. 59-30-3. Molecular formula: C19H19N7O6. Mole weight: 441.40. | |
| Folic Acid | A vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate. Group: Promotional products. Alternative Names: Folic acid. CAS No. 59-30-3. Molecular formula: C19H19N7O6. Mole weight: 441.4. Appearance: Solid. Purity: 95+%. IUPACName: (2S) -2- [ [4- [ (2-Amino-4-oxo-3H-Pteridin-6-yl) methylamino] benzoyl] amino] pentanedioic acid. Canonical SMILES: C1=CC (=CC=C1C (=O)NC (CCC (=O)O)C (=O)O)NCC2=CN=C3C (=N2)C (=O)NC (=N3)N. Density: 1.4704 g/cm³. Catalog: ACM59303-3. | |
| Folic Acid | Folic Acid is an important cofactor in the transfer of one-carbon moieties and plays big role in formation of S-adenosyl methionine and in the synthesis and repair of DNA and RNA. Folate depletion causes disruption of DNA integrity and repair enhancing carcinogenesis by altering expression of critical tumor suppressor genes. Folic Acid is a substrate of DHFR. Applications: An important cofactor in the transfer of one-carbon moieties plays role in formation of s-adenosyl met. Group: Coenzymes. Synonyms: Pteroylglutamic acid. CAS No. 59-30-3. Purity: ≥98%. Mole weight: 441.4. Appearance: Powder. Form: Solid. Pteroylglutamic acid; Folic Acid; 59-30-3. Cat No: COEC-067. | |
| Folic Acid-d2 | A vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate. Group: Biochemicals. Alternative Names: N-[4-[[ (2-Amino-3, 4-dihydro-4-oxo-6-pteridinyl) methyl]amino]benzoyl]-L-glutamic Acid-d2; Acifolic-d2; Aspol-d2; Cytofol-d2; Folacid-d2; Folacin-d2; Folbal-d2; Folcidin-d2; Foldine-d2; Folettes-d2; Foliamin-d2; Folicet-d2; Folipac-d2; Folovit-d2; Folsan-d2; Folsaure-d2; Folsav-d2; Folvite-d2; Incafolic-d2; Millafol-d2; Pteroyl-L-monoglutamic Acid-d2; Pteroylglutamic Acid-d2; Pteroylmonoglutamic Acid-d2; Vitamin Bc-d2; Vitamin Be-d2; Vitamin M-d2; NSC 3073-d2. Grades: Highly Purified. CAS No. 69022-87-3. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Folic Acid (Vitamin B9, Pteroylglutamic acid, Folacin, PteGlu) USP | A vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate. Group: Biochemicals. Alternative Names: PteGlu; ; N-[4-[[ (2-Amino-3, 4-dihydro-4-oxo-6-pteridinyl) methyl]amino]benzoyl]-L-glutamic Acid; Acifolic; Aspol; Cytofol; Folacid; Folacin; Folbal; Folcidin; Foldine; Folettes; Foliamin; Folicet; Folipac; Folovit; Folsan; Folsaure; Folsav; Folvite; Incafolic; Millafol; Pteroyl-L-monoglutamic Acid; Pteroylglutamic Acid; Pteroylmonoglutamic Acid; Vitamin Bc; Vitamin Be; Vitamin M; NSC 3073. Grades: USP. CAS No. 59-30-3. Pack Sizes: 10g, 25g, 100g, 250g, 500g. Molecular Formula: C??H??N?O?, Molecular Weight: 441.4. US Biological Life Sciences. | Worldwide |
| γ-glutamyl hydrolase | A lysosomal or secreted, thiol-dependent peptidase, most active at acidic pH. Commonly studied with folylpoly-γ-glutamate as substrate, with which the initial cleavage may release glutamate or poly-γ-glutamate of two or more residues, according to the species of origin of the enzyme. Final products are pteroyl-α-glutamate (folic acid) and free glutamate. Highly specific for the γ-glutamyl bond, but not for the C-terminal amino acid (leaving group). Action on γ-glutamyl bonds is independent of an N-terminal pteroyl moiety, but it is not known whether an N-terminal γ-Glu residue can be hydrolysed. Type example of peptidase family C26. Group: Enzymes. Synonyms: conjugase; folate conjugase; lysosomal γ-glutamyl carboxypeptid. Enzyme Commission Number: EC 3.4.19.9. CAS No. 9074-87-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4092; γ-glutamyl hydrolase; EC 3.4.19.9; 9074-87-7; conjugase; folate conjugase; lysosomal γ-glutamyl carboxypeptidase; γ-Glu-X carboxypeptidase; pteroyl-poly-γ-glutamate hydrolase; carboxypeptidase G; folic acid conjugase; poly(γ-glutamic acid) endohydrolase; polyglutamate hydrolase; poly(glutamic acid) hydrolase II; pteroylpoly-γ-glutamyl hydrolase. Cat No: EXWM-4092. | |
| glutamate carboxypeptidase | A zinc enzyme produced by pseudomonads, Flavobacterium sp. and Acinetobacter sp. Its ability to hydrolyse pteroyl-L-glutamate (folic acid) has led to its use as a folate-depleting, antitumour agent. Type example of peptidase family M20. Group: Enzymes. Synonyms: carboxypeptidase G; carboxypeptidase G1; carboxypeptidase G2; glutamyl carboxypeptidase; N-pteroyl-L-glutamate hydrolase. Enzyme Commission Number: EC 3.4.17.11. CAS No. 9074-87-7. Carboxypeptidase G. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4063; glutamate carboxypeptidase; EC 3.4.17.11; 9074-87-7; carboxypeptidase G; carboxypeptidase G1; carboxypeptidase G2; glutamyl carboxypeptidase; N-pteroyl-L-glutamate hydrolase. Cat No: EXWM-4063. | |
| glutamate carboxypeptidase II | A metallo-carboxypeptidase that is predominantly expressed as a membrane-bound enzyme of 94-100 kDa, but also exists in a soluble form. Hydrolyses α-peptide bonds in Ac-Asp-Glu, Asp-Glu, and Glu-Glu, but also γ-glutamyl bonds in γ-Glu-Glu, and folylpoly-γ-glutamates. With folylpoly-γ-glutamates, shows processive carboxypeptidase activity to produce pteroylmonoglutamate. Does not hydrolyse Ac-β-Asp-Glu. Known inhibitors: quisqualic acid, Ac-β-Asp-Glu, and 2-phosphonomethyl-pentanedioate. In peptidase family M28 of Vibrio leucyl aminopeptidase. The release of C-terminal glutamate from folylpoly-γ-glutamates is also catalysed by EC 3.4.17.11 (glutamate carboxypeptidase) and EC 3.4.19.9 (γ-Glu-X carboxypeptidase). Group: Enzymes. Synonyms: N-acetylated-γ-linked-acidic dipeptidase (NAALADas. Enzyme Commission Number: EC 3.4.17.21. CAS No. 9074-87-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4074; glutamate carboxypeptidase II; EC 3.4.17.21; 9074-87-7; N-acetylated-γ-linked-acidic dipeptidase (NAALADase); folate hydrolase; prostate-specific membrane antigen; pteroylpoly-γ-glutamate carboxypeptidase; microsomal γ-glutamyl carboxypeptidase; pteroylpolyglutamate hydrolase; folylpolyglutamate h | |
| glycine formimidoyltransferase | This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. This enzyme participates in purine metabolism and one carbon pool by folate. Group: Enzymes. Synonyms: formiminoglycine formiminotransferase; FIG formiminotransferase; glycine formiminotransferase. Enzyme Commission Number: EC 2.1.2.4. CAS No. 9029-84-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2006; glycine formimidoyltransferase; EC 2.1.2.4; 9029-84-9; formiminoglycine formiminotransferase; FIG formiminotransferase; glycine formiminotransferase. Cat No: EXWM-2006. | |
| Lentil Extract | Extract obtained from lentil fruits (Lens Esculenta) dissolved in a base of glycerin and water. Lentils are rich in proteins, oligosaccharides, and minerals including folate, thiamin, iron, and zinc. They are also very rich in Vitamin B5. Uses: Anti-aging serums, creams & lotions, sun- and after-sun care, sunscreens, face & hair masks. Group: Skin actives. CAS No. 56-81-5 / 7732-18-5 / 90063-40-4 / 122-99-6. Appearance: Light yellowish liquid, characteristic odor. Catalog: CI-SC-0692. | |
| Leucovorin Calcium | leucovorin calcium is an active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. Synonyms: IST5-002; IST5 002; IST5002; Benzyl-AMP; N6-Benzyladenosine-5'-phosphate; Folinic acid calcium salt; Calcium Folinate. Grades: >98%. CAS No. 1492-18-8. Molecular formula: C20H21N7O7.Ca. Mole weight: 513.52. | |
| Lometrexol | Lometrexol is a folate analog antimetabolite with antineoplastic activity. As the 6R diastereomer of 5,10-dideazatetrahydrofolate, lometrexol inhibits glycinamide ribonucleotide formyltransferase (GARFT), the enzyme that catalyzes the first step in the de novo purine biosynthetic pathway, thereby inhibiting DNA synthesis, arresting cells in the S phase of the cell cycle, and inhibiting tumor cell proliferation. The agent has been shown to be active against tumors that are resistant to the folate antagonist methotrexate. Uses: Antimetabolites, antineoplastic. Synonyms: Lometrexol; LMTX; LY 264618; LY-264618; LY264618. CAS No. 106400-81-1. Molecular formula: C21H25N5O6. Mole weight: 443.46. | |
| Lometrexol disodium | Lometrexol is a folate analog antimetabolite with antineoplastic activity. Synonyms: LY 264618 disodium; LY264618 disodium; NSC-722969; NSC 722969; L-Glutamic acid, N-(4-(2-((6R)-2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-d)pyrimidin-6-yl)ethyl)benzoyl)-, disodium salt. Grades: 98%. CAS No. 120408-07-3. Molecular formula: C21H23N5Na2O6. Mole weight: 487.42. | |
| methionine synthase | Contains zinc and cobamide. The enzyme becomes inactivated occasionally during its cycle by oxidation of Co(I) to Co(II). Reactivation by reductive methylation is catalysed by the enzyme itself, with S-adenosyl-L-methionine as the methyl donor and a reducing system. For the mammalian enzyme, the reducing system involves NADPH and EC 1.16.1.8, [methionine synthase] reductase. In bacteria, the reducing agent is flavodoxin, and no further catalyst is needed (the flavodoxin is kept in the reduced state by NADPH and EC 1.18.1.2, ferredoxin-NADP+ reductase). Acts on the monoglutamate as well as the triglutamate folate, in contrast with EC 2.1.1.14, 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase, which acts only on the triglutamate. Group: Enzymes. Synonyms: 5-methyltetrahydrofolate-homocysteine S-methyltransferase; 5-methyltetrahydrofolate-homocysteine transmethy. Enzyme Commission Number: EC 2.1.1.13. CAS No. 9033-23-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1727; methionine synthase; EC 2.1.1.13; 9033-23-2; 5-methyltetrahydrofolate-homocysteine S-methyltransferase; 5-methyltetrahydrofolate-homocysteine transmethylase; N-methyltetrahydrofolate:L-homocysteine methyltransferase; N5-methyltetrahydrofolate methyltransferase; N5-methyltetrahydrofolate- | |
| methionyl-tRNA formyltransferase | This enzyme participates in 3 metabolic pathways: methionine metabolism, one carbon pool by folate, and aminoacyl-tRNA biosynthesis. Group: Enzymes. Synonyms: N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase; formylmethionyl-transfer ribonucleic synthetase; methionyl ribonucleic formyltransferase; methionyl-tRNA Met formyltransferase; methionyl-tRNA transformylase; methionyl-transfer RNA transformylase; methionyl-transfer ribonucleate methyltransferase; methionyl-transfer ribonucleic transformylase. Enzyme Commission Number: EC 2.1.2.9. CAS No. 9015-76-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2010; methionyl-tRNA formyltransferase; EC 2.1.2.9; 9015-76-3; N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase; formylmethionyl-transfer ribonucleic synthetase; methionyl ribonucleic formyltransferase; methionyl-tRNA Met formyltransferase; methionyl-tRNA transformylase; methionyl-transfer RNA transformylase; methionyl-transfer ribonucleate methyltransferase; methionyl-transfer ribonucleic transformylase. Cat No: EXWM-2010. | |
| Mirvetuximab | Mirvetuximab is a monoclonal antibody that binds to folate receptor 1. Mirvetuximab has been used in the research of FRα-expressing ovarian cancer. Synonyms: M9346A. CAS No. 1453084-36-0. | |
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