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Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC 50 of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER -positive MCF-7 cells with an IC 50 of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ICI 182780; ZD 9238; ZM 182780. CAS No. 129453-61-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-13636.
Fulvestrant
Fulvestrant is a selective estrogen receptor degrader (SERD) that downregulates and degrades estrogen receptor α (ERα).1,2 It binds to rat uterine ER with an IC50 value of 44.8nM and prevents uterine weight increases induced by estradiol in immature rats (ED50> = 0.06mg/kg per day) but has no effect on uterine weight alone.3 It also decreases uterine weight in adult rats without affecting the production of luteinizing and follicle-stimulating hormones and prolactin. Fulvestrant inhibits the growth of ER-positive MCF-7 human breast cancer cells but not ER-negative BT-20 cells when used at a concentration of 1ug/ml. It also prevents tumor growth in MCF-7 and Br10 breast cancer mouse xenograft models when used at a single dose of 5mg per animal. Fulvestrant is neuroprotective in vitro against neurotoxicity induced by glutamate- and amyloid- β (1-42) (A β42) in primary rat hippocampal cells.4 Formulations containing fulvestrant have been used in the treatment of estro Group: Biochemicals. Alternative Names: (7α,17 β ) -7-[9-[4, 4, 5, 5, 5-Pentafluoropentyl) sulfinyl]nonyl]estra-1, 3, 5 (10) -triene-3, 17-diol; Faslodex; Fulvestrant; ICI 182780; ZD 182780; ZD 9238; ZM 182780. Grades: Highly Purified. CAS No. 129453-61-8. Pack Sizes: 50mg, 100mg. Molecular Formula: C??H??F?O?S, Molecular Weight: 606.77. US Biological Life Sciences.
Worldwide
Fulvestrant 17-Acetate
Fulvestrant 17-Acetate is a metabolite of Fulvestrant, which is a drug for breast cancer. Synonyms: (7α,17β)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]-estra-1,3,5(10)-triene-3,17-diol 17-Acetate; Estra-1,3,5(10)-triene-3,17-diol, 7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]-, 17-acetate, (7α,17β)-. Grade: 95%. CAS No. 261506-24-5. Molecular formula: C34H49F5O4S. Mole weight: 648.81.
Fulvestrant 17-β-D-Glucuronide
Fulvestrant 17-β-D-Glucuronide is a metabolite of Fulvestrant, which is a drug for breast cancer. Synonyms: (7α,17β)-3-Hydroxy-7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-trien-17-yl β-D-Glucopyranosiduronic Acid; Fulvestrant 17-b-D-glucuronide. Grade: ≥95%. CAS No. 261506-28-9. Molecular formula: C38H55F5O9S. Mole weight: 782.89.
Fulvestrant-17-glucuronide
Fulvestrant-17-glucuronide, an esteemed biomedical tool employed for studying hormone receptor-positive breast cancer, functions as an antagonist of estrogen receptors. Its remarkable attribute lies in inhibiting the rampant proliferation of malignant cells. Grade: > 95%. Molecular formula: C38H55F5O9S. Mole weight: 782.91.
Fulvestrant 3-β-D-Glucuronide 17-Acetate
Fulvestrant 3-β-D-Glucuronide 17-Acetate is a metabolite of Fulvestrant, which is a drug for breast cancer. Synonyms: (7α,17β)-17-(Acetyloxy)-7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-trien-3-yl β-D-Glucopyranosiduronic Acid Triacetate Methyl Ester; β-D-Glucopyranosiduronic acid, (7α,17β)-17-(acetyloxy)-7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-trien-3-yl, methyl ester, triacetate; (7α,17β)-17-Acetoxy-7-{9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl}estra-1,3,5(10)-trien-3-yl methyl 2,3,4-tri-O-acetyl-β-D-glucopyranosiduronate; 7alpha-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]-17beta-acetoxy-1,3,5(10)-estratriene-3-yl 2-O,3-O,4-O-triacetyl-beta-D-glucopyranosiduronic acid methyl ester. Grade: >95%. CAS No. 403656-84-8. Molecular formula: C47H65F5O13S. Mole weight: 965.07.
Fulvestrant-3-Glucuronide
Fulvestrant-3-Glucuronide is a metabolite of Fulvestrant. Synonyms: (7a,17b)-17-Hydroxy-7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-trien-3-yl b-D-glucopyranosiduronic acid. Grade: > 95%. CAS No. 261506-27-8. Molecular formula: C38H55F5O9S. Mole weight: 782.90.
Fulvestrant-3-Glucuronide Lithium Salt
Fulvestrant-3-Glucuronide Lithium Salt is an impurity of Fulvestrant, which is a drug for breast cancer. Molecular formula: C38H54F5O9SLi. Mole weight: 788.83.
Fulvestrant-3-sulfate
Fulvestrant-3-sulfate is a potent pharmaceutical compound primarily employed in the research of hormone receptor positive breast cancer. It works by inhibiting estrogen receptors, thereby minimizing the growth and spread of cancer cells. Grade: > 95%. Molecular formula: C32H47F5O6S2. Mole weight: 686.85.
Fulvestrant 3-Sulfate Sodium Salt is a metabolite of Fulvestrant, which is a drug for breast cancer. Uses: A metabolite of fulvestrant (f862500). Synonyms: (7α,17β)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol 3-(Hydrogen Sulfate) Monosodium Salt. Grade: ≥95%. CAS No. 403656-83-7. Molecular formula: C32H46F5NaO6S2. Mole weight: 708.82.
Fulvestrant 3-Sulfooxy 17-Acetate
Fulvestrant 3-Sulfooxy 17-Acetate is a metabolite of Fulvestrant, which is a drug for breast cancer. Molecular formula: C34H49F5O7S2. Mole weight: 728.87.
A metabolite of Fulvestrant. Group: Biochemicals. Alternative Names: (7α,17 β ) -7-[9-[ (4, 4, 5, 5, 5-Pentafluoropentyl) sulfonyl]nonyl]estra-1, 3, 5 (10) -triene-3, 17-diol. Grades: Highly Purified. CAS No. 98008-06-1. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
Fulvestrant-9-sulfone-[d3]
An isotope labelled metabolite of Fulvestrant. Fulvestrant is a selective estrogen receptor degrader and can be used to treat hormone receptor (HR)-positive metastatic breast cancer. Synonyms: Fulvestrant-9-sulfone D3; (7a,17b)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfonyl]nonyl]estra-1,3,5(10)-triene-3,17-diol-d3. Grade: 95% by HPLC; 98% atom D. Molecular formula: C32H44D3F5O4S. Mole weight: 625.79.
Fulvestrant Beta-Isomer
Fulvestrant Beta-Isomer, a drug utilized in the management of metastatic breast cancer associated with hormone receptor positivity, acts as a selective estrogen receptor down-regulator that impedes breast cancer cell growth by binding to and disintegrating estrogen receptors. Its modus operandi is to lower the expression of estrogen receptors. Synonyms: (7β,17β)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol; Fulvestrant EP Impurity A; 7β-fulvestrant; 7beta-fulvestrant; Fulvestrant β-isomer. Grade: > 95%. CAS No. 407577-53-1. Molecular formula: C32H47F5O3S. Mole weight: 606.79.
Fulvestrant EP Impurity C is an impurity of Fulvestrant, an estrogen receptor antagonist used as a medication indicated for the treatment of hormone receptor (HR)-positive metastatic breast cancer in postmenopausal women. Synonyms: 7-[9-[[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17β-diol (Mixture of Diastereomers). CAS No. 2482852-42-4. Molecular formula: C41H65F5O4S2. Mole weight: 781.07.
Fulvestrant EP Impurity D
Fulvestrant EP Impurity D is an impurity of Fulvestrant, which is an estrogen receptor antagonist used as a medication indicated for the treatment of hormone receptor (HR)-positive metastatic breast cancer in postmenopausal women. Synonyms: 7,7'-Nonane-1,9-diylbis[estra-1,3,5(10)-triene-3,17β-diol]; Fulvestrant Sterol Dimer (Mixture of Diastereomers). Grade: 95%. CAS No. 2483797-59-5. Molecular formula: C45H64O4. Mole weight: 668.99.
Fulvestrant EP Impurity F
Fulvestrant EP Impurity F is an impurity of Fulvestrant, an estrogen receptor antagonist used as a medication indicated for the treatment of hormone receptor (HR)-positive metastatic breast cancer in postmenopausal women. Synonyms: 7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-3,17beta-dihydroxyestra-1,3,5(10)-trien-6-one. Molecular formula: C32H45F5O4S. Mole weight: 620.76.
Fulvestrant Extended
Fulvestrant Extended is an impurity of Fulvestrant, an estrogen receptor antagonist used as a medication indicated for the treatment of hormone receptor (HR)-positive metastatic breast cancer in postmenopausal women. Synonyms: (7R,8R,9S,13S,14S,17S)-13-methyl-7-(9-((9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol. Grade: > 95%. Molecular formula: C41H65F5O4S. Mole weight: 781.09.
Fulvestrant Impurity 20 is an impurity of Fulvestrant, which is a drug for breast cancer. Synonyms: Estr-4-en-3-one, 17-(acetyloxy)-7-(9-hydroxynonyl)-, (7alpha,17beta)-; DTXSID901198837; (7alpha,17beta)-17-(Acetyloxy)-7-(9-hydroxynonyl)estr-4-en-3-one; (7R,8R,9S,10R,13S,14S,17S)-7-(9-hydroxynonyl)-13-methyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate. Grade: >98%. CAS No. 875573-64-1. Molecular formula: C29H46O4. Mole weight: 458.67.
Fulvestrant Impurity 5 is an impurity of Fulvestrant, which is a drug for breast cancer. Molecular formula: C34H47F9O3S. Mole weight: 706.78.
Fulvestrant Impurity 6
Fulvestrant Impurity 6 is an impurity of Fulvestrant, which is a drug for breast cancer. Molecular formula: C54H82O5S. Mole weight: 843.29.
Fulvestrant Impurity 7
Fulvestrant Impurity 7 is an impurity of Fulvestrant, which is a drug for breast cancer. CAS No. 1673530-91-0. Molecular formula: C32H47F5O2S. Mole weight: 590.77.
Fulvestrant Impurity 8
Fulvestrant Impurity 8 is an impurity of Fulvestrant, which is a drug for breast cancer. Molecular formula: C32H46BrF5O2S. Mole weight: 669.67.
Fulvestrant Impurity 9
Fulvestrant Impurity 9 is an impurity of Fulvestrant, which is a drug for breast cancer. Molecular formula: C32H46BrF5O2S. Mole weight: 669.67.
Fulvestrant Impurity 9
Fulvestrant Impurity 9. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1316849-17-8. Molecular formula: C32H47F5O3S. Mole weight: 606.78. Catalog: APB1316849178.
Fulvestrant (Standard)
Fulvestrant (Standard) is the analytical standard of Fulvestrant. This product is intended for research and analytical applications. Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC 50 of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER -positive MCF-7 cells with an IC 50 of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ICI 182780(Standard); ZD 9238(Standard); ZM 182780 (Standard). CAS No. 129453-61-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13636R.
Fulvestrant Sulfone
Fulvestrant Sulfone is a ligand-independent activator of estrogen function. It is a metabolite of Fulvestrant, an estrogen receptor antagonist used as a medication indicated for the treatment of hormone receptor (HR)-positive metastatic breast cancer in postmenopausal women. Synonyms: Fulvestrant-9-Sulfone; Fulvestrant EP Impurity B; (7α,17β)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfonyl]nonyl]estra-1,3,5(10)-triene-3,17-diol. Grade: > 95%. CAS No. 98008-06-1. Molecular formula: C32H47F5O4S. Mole weight: 622.78.
Fulvestrant System Suitability Mixture
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
17-Keto Fulvestrant
17-Keto Fulvestrant is an impurity of Fulvestrant. Synonyms: (7α)-3-Hydroxy-7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-trien-17-one. Grade: > 95%. CAS No. 403656-89-3. Molecular formula: C32H45F5O3S. Mole weight: 604.77.
6,7-Dehydro Fulvestrant-9-Sulfone
An impurity of Fulvestrant, which is a drug for breast cancer. Synonyms: 17β-6,7-Dehydro-7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfonyl]nonyl]estra-1,3,5(10)-triene-3,17-diol; (8R,9S,13S,14S,17S)-13-Methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfonyl)nonyl)-8,9,12,13,14,15,16,17-octahydro-11H-cyclopenta[a]phenanthrene-3,17-diol; 7alpha-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfonyl]nonyl]estra-1,3,5(10),6(7)-tetraene-3,17beta-diol. Grade: ≥95%. Molecular formula: C32H45F5O4S. Mole weight: 620.75.
?6-Fulvestrant
?6-Fulvestrant is an impurity of Fulvestrant, which is a drug for breast cancer. Synonyms: 7-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10),6-tetraene-3,17β-diol; ?6,7-Fulvestrant; Fulvestrant EP Impurity E. CAS No. 2170200-14-1. Molecular formula: C32H45F5O3S. Mole weight: 604.75.
?6-Fulvestrant
Fulvestrant impurity E. Group: Biochemicals. Alternative Names: 7-[9-[ (4, 4, 5, 5, 5-Pentafluoropentyl) sulfinyl]nonyl]estra-1, 3, 5 (10) , 6-tetraene-3, 17 β-diol; Fulvestrant Impurity E. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
6-Keto Fulvestrant
6-Keto Fulvestrant is an impurity of Fulvestrant, an estrogen receptor antagonist used as a medication indicated for the treatment of hormone receptor (HR)-positive metastatic breast cancer in postmenopausal women. Synonyms: 6-Keto-Fulvestrant; (7a,17ss)-7-[9-[4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]-3,17ss-dihydroxyestra-1,3,5(10)-trien-6-one. Grade: > 95%. Molecular formula: C32H45F5O4S. Mole weight: 620.77.
6-Keto Fulvestrant
6-Keto Fulvestrant. Uses: For analytical and research use. Group: Impurity standards. Catalog: APS00573. Format: Neat.
6-Keto Fulvestrant
Fulvestrant impurity F. Group: Biochemicals. Alternative Names: (7α,17 β ) -7-[9-[4, 4, 5, 5, 5-Pentafluoropentyl) sulfinyl]nonyl]-3, 17 β-dihydroxyestra-1,3,5(10)-trien-6-one; Fulvestrant Impurity F. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
7 β-Fulvestrant
Fulvestrant impurity A. The S-isomer of Fulvestrant. Group: Biochemicals. Alternative Names: (7 β,17 β ) -7-[9-[ (4, 4, 5, 5, 5-Pentafluoropentyl) sulfinyl]nonyl]estra-1, 3, 5 (10) -triene-3, 17-diol; Fulvestrant Impurity A. Grades: Highly Purified. CAS No. 407577-53-1. Pack Sizes: 1mg. US Biological Life Sciences.
Delta-6,7-Fulvestrant is an impurity of Fulvestrant, which is a drug for breast cancer. Grade: > 95%. Molecular formula: C32H45F5O3S. Mole weight: 604.75.
Fulvestrant impurity E derivative. Used in the preparation of antiestrogenic 17-alkylene-16α-hydroxyestratrienes for cancer treatment. Group: Biochemicals. Alternative Names: 7-[9-[ (4, 4, 5, 5, 5-Pentafluoropentyl) sulfenyl]nonyl]--3, 17 β-bis-(O-tetrahydro-2H-pyran-2-yl)estra-1,3,5(10)-triene-6-one. Grades: Highly Purified. CAS No. 862700-70-7. Pack Sizes: 5mg. US Biological Life Sciences.
Fulvestrant impurity E derivative. Group: Biochemicals. Alternative Names: 7-[9-[ (4, 4, 5, 5, 5-Pentafluoropentyl) sulfenyl]nonyl]estra-1, 3, 5 (10) -triene-6-ol-3, 17 β-bis-(O-tetrahydro-2H-pyran-2-yl). Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
S-Deoxo ?6-Fulvestrant
Fulvestrant impurity E derivative. Group: Biochemicals. Alternative Names: 7-[9-[ (4, 4, 5, 5, 5-Pentafluoropentyl) sulfenyl]nonyl]estra-1, 3, 5 (10) , 6-tetraene-3, 17 β-diol; S-Deoxo Fulvestrant Impurity E. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
S-Deoxo-6-oxo-fulvestrant
Fulvestrant impurity E derivative. Used in the preparation of steroids precursor with hormonal activity. Group: Biochemicals. Alternative Names: (7α,17 β ) -3, 17-Dihydroxy-7-[9-[ (4, 4, 5, 5, 5-pentafluoropentyl) thio]nonyl]-estra-1, 3, 5 (10) -trien-6-one. Grades: Highly Purified. CAS No. 1107606-70-1. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
S-Deoxo-6-oxo-fulvestrant
S-Deoxo-6-oxo-fulvestrant. Uses: For analytical and research use. Group: Impurity standards. Pack Sizes: 2.5MG. Catalog: APS012062. Format: Neat. Shipping: Room Temperature.
(17β)-3,17-Bis-O-[(tetrahydro-2H-pyran-2-yl)-6-O-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfenyl]nonyl-estra-1,3,5(10),6(7)-tetraene is an impurity of Fulvestrant, which is a selective estrogen receptor degrader (SERD) used to treat hormone receptor (HR)-positive metastatic breast cancer in postmenopausal women. Molecular formula: C42H61F5O5S. Mole weight: 772.99.
1-Bromo-9- (tert-butyldimethylsilyloxy) nonane
1-Bromo-9- (tert-butyldimethylsilyloxy) nonane is used in the preparation of Fulvestrant (F862500) intermediate. Group: Biochemicals. Grades: Highly Purified. CAS No. 149051-24-1. Pack Sizes: 100mg, 500mg. Molecular Formula: C15H33BrOSi, Molecular Weight: 337.41. US Biological Life Sciences.
Worldwide
6-Dehydronandrolone acetate
6-Dehydronandrolone acetate is a starting material for synthesis of Fulvestrant. Fulvestrant is an estrogen receptor antagonist that can be used for the research of breast cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2590-41-2. Pack Sizes: 100 mg. Product ID: HY-79315.
7,7-Nonane-1,9-diylbis[estra-1,3,5(10)-triene-3,17 β-diol (Mixture of Diastereomers)
Fulvestrant impurity D. Group: Biochemicals. Alternative Names: Fulvestrant Impurity D. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
7,7'-Nonane-1,9-diylbis[estra-1,3,5(10)-triene-3,17β-diol] Tetraacetate is an impurity of Fulvestrant, which is a drug for breast cancer. Synonyms: Fulvestrant Impurity D Tetraacetate. Molecular formula: C53H72O8. Mole weight: 837.13.
Protected Fulvestrant impurity D. Group: Biochemicals. Alternative Names: Fulvestrant Impurity D Tetraacetate. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Fulvestrant impurity C. Group: Biochemicals. Alternative Names: Fulvestrant Impurity C. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
(7α,17β)-17-Hydroxy-7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]estr-4-en-3-one is an impurity of Fulvestrant, which is a selective estrogen receptor degrader (SERD) used to treat hormone receptor (HR)-positive metastatic breast cancer in postmenopausal women. Synonyms: Estr-4-en-3-one, 17-hydroxy-7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]-, (7α,17β)-; 17-Hydroxy-7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]-(7α,17β) estr-4-en-3-one. CAS No. 1334316-46-9. Molecular formula: C32H49F5O3S. Mole weight: 608.78.