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Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC 50 of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER -positive MCF-7 cells with an IC 50 of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ICI 182780; ZD 9238; ZM 182780. CAS No. 129453-61-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-13636.
Fulvestrant
Fulvestrant is a selective estrogen receptor degrader (SERD) that downregulates and degrades estrogen receptor α (ERα).1,2 It binds to rat uterine ER with an IC50 value of 44.8nM and prevents uterine weight increases induced by estradiol in immature rats (ED50> = 0.06mg/kg per day) but has no effect on uterine weight alone.3 It also decreases uterine weight in adult rats without affecting the production of luteinizing and follicle-stimulating hormones and prolactin. Fulvestrant inhibits the growth of ER-positive MCF-7 human breast cancer cells but not ER-negative BT-20 cells when used at a concentration of 1ug/ml. It also prevents tumor growth in MCF-7 and Br10 breast cancer mouse xenograft models when used at a single dose of 5mg per animal. Fulvestrant is neuroprotective in vitro against neurotoxicity induced by glutamate- and amyloid- β (1-42) (A β42) in primary rat hippocampal cells.4 Formulations containing fulvestrant have been used in the treatment of estro Group: Biochemicals. Alternative Names: (7α,17 β ) -7-[9-[4, 4, 5, 5, 5-Pentafluoropentyl) sulfinyl]nonyl]estra-1, 3, 5 (10) -triene-3, 17-diol; Faslodex; Fulvestrant; ICI 182780; ZD 182780; ZD 9238; ZM 182780. Grades: Highly Purified. CAS No. 129453-61-8. Pack Sizes: 50mg, 100mg. Molecular Formula: C??H??F?O?S, Molecular Weight: 606.77. US Biological Life Sciences.
Worldwide
Fulvestrant 17-Acetate
Fulvestrant 17-Acetate is a metabolite of Fulvestrant, which is a drug for breast cancer. Synonyms: (7α,17β)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]-estra-1,3,5(10)-triene-3,17-diol 17-Acetate; Estra-1,3,5(10)-triene-3,17-diol, 7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]-, 17-acetate, (7α,17β)-. Grades: 95%. CAS No. 261506-24-5. Molecular formula: C34H49F5O4S. Mole weight: 648.81.
Fulvestrant 17-β-D-Glucuronide
Fulvestrant 17-β-D-Glucuronide is a metabolite of Fulvestrant, which is a drug for breast cancer. Synonyms: (7α , 17β ) -3-Hydroxy-7-[9-[ (4, 4, 5, 5, 5-pentafluoropentyl) sulfinyl]nonyl]estra-1, 3, 5 (10) -trien-17-yl β-D-Glucopyranosiduronic Acid; Fulvestrant 17-b-D-glucuronide. Grades: ≥95%. CAS No. 261506-28-9. Molecular formula: C38H55F5O9S. Mole weight: 782.89.
Fulvestrant 3-β-D-Glucuronide 17-Acetate is a metabolite of Fulvestrant, which is a drug for breast cancer. Synonyms: (7α , 17β ) -17- (Acetyloxy) -7-[9-[ (4, 4, 5, 5, 5-pentafluoropentyl) sulfinyl]nonyl]estra-1, 3, 5 (10) -trien-3-yl β-D-Glucopyranosiduronic Acid Triacetate Methyl Ester; β-D-Glucopyranosiduronic acid, (7α , 17β ) -17- (acetyloxy) -7-[9-[ (4, 4, 5, 5, 5-pentafluoropentyl) sulfinyl]nonyl]estra-1, 3, 5 (10) -trien-3-yl, methyl ester, triacetate; (7α , 17β ) -17-Acetoxy-7-{9-[ (4, 4, 5, 5, 5-pentafluoropentyl) sulfinyl]nonyl}estra-1, 3, 5 (10) -trien-3-yl methyl 2,3,4-tri-O-acetyl-β-D-glucopyranosiduronate; 7alpha-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]-17beta-acetoxy-1,3,5(10)-estratriene-3-yl 2-O,3-O,4-O-triacetyl-beta-D-glucopyranosiduronic acid methyl ester. Grades: >95%. CAS No. 403656-84-8. Molecular formula: C47H65F5O13S. Mole weight: 965.07.
Fulvestrant-3-Glucuronide
Fulvestrant-3-Glucuronide is a metabolite of Fulvestrant. Synonyms: (7a, 17b) -17-Hydroxy-7-[9-[ (4, 4, 5, 5, 5-pentafluoropentyl) sulfinyl]nonyl]estra-1, 3, 5 (10) -trien-3-yl b-D-glucopyranosiduronic acid. Grades: > 95%. CAS No. 261506-27-8. Molecular formula: C38H55F5O9S. Mole weight: 782.90.
Fulvestrant-3-Glucuronide Lithium Salt
Fulvestrant-3-Glucuronide Lithium Salt is an impurity of Fulvestrant, which is a drug for breast cancer. Molecular formula: C38H54F5O9SLi. Mole weight: 788.83.
Fulvestrant 3-Sulfate Sodium Salt is a metabolite of Fulvestrant, which is a drug for breast cancer. Uses: A metabolite of fulvestrant (f862500). Synonyms: (7α , 17β ) -7-[9-[ (4, 4, 5, 5, 5-Pentafluoropentyl) sulfinyl]nonyl]estra-1, 3, 5 (10) -triene-3, 17-diol 3-(Hydrogen Sulfate) Monosodium Salt. Grades: ≥95%. CAS No. 403656-83-7. Molecular formula: C32H46F5NaO6S2. Mole weight: 708.82.
Fulvestrant 3-Sulfooxy 17-Acetate
Fulvestrant 3-Sulfooxy 17-Acetate is a metabolite of Fulvestrant, which is a drug for breast cancer. Molecular formula: C34H49F5O7S2. Mole weight: 728.87.
A metabolite of Fulvestrant. Group: Biochemicals. Alternative Names: (7α,17 β ) -7-[9-[ (4, 4, 5, 5, 5-Pentafluoropentyl) sulfonyl]nonyl]estra-1, 3, 5 (10) -triene-3, 17-diol. Grades: Highly Purified. CAS No. 98008-06-1. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
Fulvestrant-9-Sulfone
Fulvestrant-9-Sulfone is a ligand-independent activator of estrogen function. It is a metabolite of Fulvestrant. Synonyms: (7α , 17β ) -7-[9-[ (4, 4, 5, 5, 5-Pentafluoropentyl) sulfonyl]nonyl]estra-1, 3, 5 (10) -triene-3, 17-diol. Grades: > 95%. CAS No. 98008-06-1. Molecular formula: C32H47F5O4S. Mole weight: 622.78.
Fulvestrant Beta-Isomer
Fulvestrant Beta-Isomer, a drug utilized in the management of metastatic breast cancer associated with hormone receptor positivity, acts as a selective estrogen receptor down-regulator that impedes breast cancer cell growth by binding to and disintegrating estrogen receptors. Its modus operandi is to lower the expression of estrogen receptors. Synonyms: (7β , 17β ) -7-[9-[ (4, 4, 5, 5, 5-Pentafluoropentyl) sulfinyl]nonyl]estra-1, 3, 5 (10) -triene-3, 17-diol; Fulvestrant Impurity A. Grades: > 95%. CAS No. 407577-53-1. Molecular formula: C32H47F5O3S. Mole weight: 606.79.
Fulvestrant EP Impurity A. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (7S,8R,9S,13S,14S,17S)-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol. CAS No. 407577-53-1. Molecular Formula: C32H47F5O3S. Mole Weight: 606.77. Catalog: APB407577531.
Fulvestrant EP Impurity B
Fulvestrant EP Impurity B. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (7R,8R,9S,13S,14S,17S)-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfonyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol. CAS No. 98008-06-1. Molecular Formula: C32H47F5O4S. Mole Weight: 622.77. Catalog: APB98008061.
Fulvestrant EP Impurity C
Fulvestrant EP Impurity C. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (7R, 8R, 9S, 13S, 14S, 17S) -13-methyl-7- (9- ( (9- ( (4, 4, 5, 5, 5-pentafluoropentyl) sulfinyl) nonyl) sulfinyl) nonyl) -7, 8, 9, 11, 12, 13, 14, 15, 16, 17-decahydro-6H-cyclopenta[a]phenanthrene-3, 17-diol. Molecular Formula: C41H65F5O4S2. Mole Weight: 781.07. Catalog: APB02220.
Fulvestrant EP Impurity C
Fulvestrant EP Impurity C. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2482852-42-4. Molecular Formula: C41H65F5O4S2. Mole Weight: 781.08. Catalog: APB2482852424.
Fulvestrant EP Impurity D
Fulvestrant EP Impurity D. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (8R, 8'R, 9S, 9'S, 13S, 13'S, 14S, 14'S, 17S, 17'S)-7, 7'-(nonane-1, 9-diyl)bis(13-methyl-7, 8, 9, 11, 12, 13, 14, 15, 16, 17-decahydro-6H-cyclopenta[a]phenanthrene-3, 17-diol). Molecular Formula: C45H64O4. Mole Weight: 668.99. Catalog: APB06032.
Fulvestrant EP Impurity D (Fulvestrant Sterol Dimer) (Mixture of Diastereomers)
Fulvestrant EP Impurity D (Fulvestrant Sterol Dimer) (Mixture of Diastereomers). Uses: For analytical and research use. Group: Impurity standards. CAS No. 2483797-59-5. Molecular Formula: C45H64O4. Mole Weight: 669. Catalog: APB2483797595.
Fulvestrant EP Impurity D (Mixture of Diastereomers)
Fulvestrant EP Impurity D (Mixture of Diastereomers) is an impurity of Fulvestrant, which is a selective estrogen receptor degrader (SERD) used to treat hormone receptor (HR)-positive metastatic breast cancer in postmenopausal women. Synonyms: Fulvestrant Sterol Dimer; 7,7'-nonane-1,9-diylbis(estra-1,3,5(10)-triene-3,17beta-diol). Molecular formula: C45H64O4. Mole weight: 668.98.
Fulvestrant EP Impurity E
Fulvestrant EP Impurity E. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (8R,9S,13S,14S,17S)-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-9,11,12,13,14,15,16,17-octahydro-8H-cyclopenta[a]phenanthrene-3,17-diol. CAS No. 2170200-14-1. Molecular Formula: C32H45F5O3S. Mole Weight: 604.75. Catalog: APB2170200141.
Fulvestrant EP Impurity F
Fulvestrant EP Impurity F. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-6-one. Molecular Formula: C32H45F5O4S. Mole Weight: 620.75. Catalog: APB02219.
Fulvestrant Extended
Fulvestrant Extended is an impurity of Fulvestrant, an estrogen receptor antagonist used as a medication indicated for the treatment of hormone receptor (HR)-positive metastatic breast cancer in postmenopausal women. Synonyms: (7R, 8R, 9S, 13S, 14S, 17S) -13-methyl-7- (9- ( (9- ( (4, 4, 5, 5, 5-pentafluoropentyl) sulfinyl) nonyl) sulfinyl) nonyl) -7, 8, 9, 11, 12, 13, 14, 15, 16, 17-decahydro-6H-cyclopenta[a]phenanthrene-3, 17-diol. Grades: > 95%. Molecular formula: C41H65F5O4S. Mole weight: 781.09.
Fulvestrant Impurity 1
Fulvestrant Impurity 1. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (8R,9S,13S,14S,17S)-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-9,11,12,13,14,15,16,17-octahydro-8H-cyclopenta[a]phenanthrene-3,17-diol. Molecular Formula: C32H45F5O3S. Mole Weight: 604.75. Catalog: APB06033.
Fulvestrant Impurity 1
Fulvestrant Impurity 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2170200-16-3. Molecular Formula: C32H45F5O2S. Mole Weight: 588.76. Catalog: APB2170200163.
Fulvestrant Impurity 20 is an impurity of Fulvestrant, which is a drug for breast cancer. Synonyms: Estr-4-en-3-one, 17-(acetyloxy)-7-(9-hydroxynonyl)-, (7alpha,17beta)-; DTXSID901198837; (7alpha,17beta)-17-(Acetyloxy)-7-(9-hydroxynonyl)estr-4-en-3-one; (7R,8R,9S,10R,13S,14S,17S)-7-(9-hydroxynonyl)-13-methyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate. Grades: >98%. CAS No. 875573-64-1. Molecular formula: C29H46O4. Mole weight: 458.67.
Fulvestrant Impurity 3
Fulvestrant Impurity 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 252947-01-6. Molecular Formula: C6H9F5O3S. Mole Weight: 256.19. Catalog: APB252947016.
Fulvestrant Impurity 40. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (7R)-7-(9-((tert-butyldimethylsilyl)oxy)nonyl)-13-methyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate. CAS No. 875573-60-7. Molecular Formula: C35H60O4Si. Mole Weight: 572.43. Catalog: APB875573607.
Fulvestrant Impurity 45
Fulvestrant Impurity 45. Uses: For analytical and research use. Group: Impurity standards. CAS No. 30956-28-6. Molecular Formula: C2H5ClN2O. Mole Weight: 108.52. Catalog: APB30956286.
Fulvestrant Impurity 5
Fulvestrant Impurity 5 is an impurity of Fulvestrant, which is a drug for breast cancer. Molecular formula: C34H47F9O3S. Mole weight: 706.78.
Fulvestrant Impurity 5
Fulvestrant Impurity 5. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2490287-82-4. Molecular Formula: C29H43ClO3. Mole Weight: 475.11. Catalog: APB2490287824.
Fulvestrant Impurity 6
Fulvestrant Impurity 6 is an impurity of Fulvestrant, which is a drug for breast cancer. Molecular formula: C54H82O5S. Mole weight: 843.29.
Fulvestrant Impurity 7
Fulvestrant Impurity 7 is an impurity of Fulvestrant, which is a drug for breast cancer. CAS No. 1673530-91-0. Molecular formula: C32H47F5O2S. Mole weight: 590.77.
Fulvestrant Impurity 8
Fulvestrant Impurity 8 is an impurity of Fulvestrant, which is a drug for breast cancer. Molecular formula: C32H46BrF5O2S. Mole weight: 669.67.
Fulvestrant Impurity 9
Fulvestrant Impurity 9 is an impurity of Fulvestrant, which is a drug for breast cancer. Molecular formula: C32H46BrF5O2S. Mole weight: 669.67.
Fulvestrant Impurity 9
Fulvestrant Impurity 9. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1316849-17-8. Molecular Formula: C32H47F5O3S. Mole Weight: 606.78. Catalog: APB1316849178.
Fulvestrant Impurity C
7-[9-[[9-[ (4, 4, 5, 5, 5-Pentafluoropentyl) sulfinyl]nonyl]sulfinyl]nonyl]estra-1, 3, 5 (10) -triene-3, 17β -diol (Mixture of Diastereomers) is an impurity of Fulvestrant, which is a drug for breast cancer. Synonyms: 7-[9-[[9-[ (4, 4, 5, 5, 5-Pentafluoropentyl) sulfinyl]nonyl]sulfinyl]nonyl]estra-1, 3, 5 (10) -triene-3, 17β -diol (Mixture of Diastereomers). Molecular formula: C41H65F5O4S2. Mole weight: 781.07.
Fulvestrant Impurity J
Fulvestrant Impurity J. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (7R,8R,9S,13S,14S,17S)-3-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl acetate. CAS No. 261506-24-5. Molecular Formula: C34H49F5O4S. Mole Weight: 648.81. Catalog: APB261506245.
Fulvestrant (Standard)
Fulvestrant (Standard) is the analytical standard of Fulvestrant. This product is intended for research and analytical applications. Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC 50 of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER -positive MCF-7 cells with an IC 50 of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ICI 182780(Standard); ZD 9238(Standard); ZM 182780 (Standard). CAS No. 129453-61-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13636R.
17-Keto Fulvestrant
17-Keto Fulvestrant is an impurity of Fulvestrant. Synonyms: (7α ) -3-Hydroxy-7-[9-[ (4, 4, 5, 5, 5-pentafluoropentyl) sulfinyl]nonyl]estra-1, 3, 5 (10) -trien-17-one. Grades: > 95%. CAS No. 403656-89-3. Molecular formula: C32H45F5O3S. Mole weight: 604.77.
?6-Fulvestrant
?6-Fulvestrant is an impurity of Fulvestrant, which is a drug for breast cancer. Synonyms: 7-[9-[ (4, 4, 5, 5, 5-Pentafluoropentyl) sulfinyl]nonyl]estra-1, 3, 5 (10) , 6-tetraene-3, 17β -diol; Fulvestrant Impurity E. CAS No. 2170200-14-1. Molecular formula: C32H45F5O3S. Mole weight: 604.75.
?6-Fulvestrant
Fulvestrant impurity E. Group: Biochemicals. Alternative Names: 7-[9-[ (4, 4, 5, 5, 5-Pentafluoropentyl) sulfinyl]nonyl]estra-1, 3, 5 (10) , 6-tetraene-3, 17 β-diol; Fulvestrant Impurity E. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
6-Keto Fulvestrant
6-Keto Fulvestrant is an impurity of Fulvestrant, an estrogen receptor antagonist used as a medication indicated for the treatment of hormone receptor (HR)-positive metastatic breast cancer in postmenopausal women. Synonyms: (7α,17β)-7-[9-[4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]-3,17β-dihydroxyestra-1,3,5(10)-trien-6-one; Fulvestrant Impurity F. Grades: > 95%. Molecular formula: C32H45F5O4S. Mole weight: 620.77.
6-Keto Fulvestrant
6-Keto Fulvestrant. Uses: For analytical and research use. Group: Impurity standards. Catalog: APS00573. Format: Neat.
6-Keto Fulvestrant
Fulvestrant impurity F. Group: Biochemicals. Alternative Names: (7α,17 β ) -7-[9-[4, 4, 5, 5, 5-Pentafluoropentyl) sulfinyl]nonyl]-3, 17 β-dihydroxyestra-1,3,5(10)-trien-6-one; Fulvestrant Impurity F. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
7 β-Fulvestrant
Fulvestrant impurity A. The S-isomer of Fulvestrant. Group: Biochemicals. Alternative Names: (7 β,17 β ) -7-[9-[ (4, 4, 5, 5, 5-Pentafluoropentyl) sulfinyl]nonyl]estra-1, 3, 5 (10) -triene-3, 17-diol; Fulvestrant Impurity A. Grades: Highly Purified. CAS No. 407577-53-1. Pack Sizes: 1mg. US Biological Life Sciences.
Delta-6,7-Fulvestrant is an impurity of Fulvestrant, which is a drug for breast cancer. Grades: > 95%. Molecular formula: C32H45F5O3S. Mole weight: 604.75.
Fulvestrant impurity E derivative. Used in the preparation of antiestrogenic 17-alkylene-16α-hydroxyestratrienes for cancer treatment. Group: Biochemicals. Alternative Names: 7-[9-[ (4, 4, 5, 5, 5-Pentafluoropentyl) sulfenyl]nonyl]--3, 17 β-bis-(O-tetrahydro-2H-pyran-2-yl)estra-1,3,5(10)-triene-6-one. Grades: Highly Purified. CAS No. 862700-70-7. Pack Sizes: 5mg. US Biological Life Sciences.
S-Deoxo-3,17β-bis-(O-tetrahydro-2H-pyran-2-yl)-6-oxo-fulvestrant is an impurity of Fulvestrant, which is a selective estrogen receptor degrader (SERD) used to treat hormone receptor (HR)-positive metastatic breast cancer in postmenopausal women. Synonyms: 7-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfenyl]nonyl]-3,17β-bis-(O-tetrahydro-2H-pyran-2-yl)estra-1,3,5(10)-triene-6-one; (17β)-7-{9-[(4,4,5,5,5-Pentafluoropentyl)sulfanyl]nonyl}-3,17-bis(tetrahydro-2H-pyran-2-yloxy)estra-1,3,5(10)-trien-6-one; Estra-1,3,5(10)-trien-6-one, 7-[9-[(4,4,5,5,5-pentafluoropentyl)thio]nonyl]-3,17-bis[(tetrahydro-2H-pyran-2-yl)oxy]-, (17β)-. Grades: ≥95%. CAS No. 862700-70-7. Molecular formula: C42H61F5O5S. Mole weight: 772.99.