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An antagonist of gastrin/CCK. Synonyms: Urea, N-[1-cyclohexyl-2,3,4,5-tetrahydro-2,4-dioxo-5-[2-oxo-2-(1-pyrrolidinyl)ethyl]-1H-1,5-benzodiazepin-3-yl]-N'-(4-fluorophenyl)-. CAS No. 162271-52-5. Molecular formula: C28H32FN5O4. Mole weight: 521.58.
Gastrin i(1-14)(human)
Heterocyclic Organic Compound. Alternative Names: GASTRIN I HUMAN FRAGMENT 1-14;GASTRIN I (1-14) (HUMAN);PGLU-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP;PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-OH;PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP;gastrin I fragment human 1-. CAS No. 100940-57-6. Molecular formula: C79H100N16O27. Mole weight: 1705.73. Purity: 0.96. Catalog: ACM100940576.
Gastrin I (1-14), human
Gastrin I (1-14), human is the 1-14 fragment of human Gastrin I peptide. Gastrin I is an endogenous gastrointestinal peptide hormone. Synonyms: H-Pyr-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-OH; L-pyroglutamyl-glycyl-L-prolyl-L-tryptophyl-L-leucyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alanyl-L-tyrosyl-glycyl-L-tryptophan; gastrin I fragment human 1-14; 18-31-Gastrin I (swine), 18-(5-oxo-L-proline)-22-L-leucine-. Grades: 95%. CAS No. 100940-57-6. Molecular formula: C79H100N16O27. Mole weight: 1705.73.
Gastrin I (human)
Gastrin I (human). Group: Biochemicals. Grades: Purified. CAS No. 10047-33-3. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Gastrin I (human)
Gastrin I (human) is an endogenous peptide produced by stomach and it acts as a selective CCK2 receptor agonist. Gastrin I stimulates gastric acid secretion in vivo, and increases levels of cytosolic calcium in isolated rabbit stomach parietal cells (EC50 = 11 nM). Synonyms: Gastrin-17; Little gastrin I; Gastrin I human. Grades: 95%. CAS No. 10047-33-3. Molecular formula: C97H124N20O31S. Mole weight: 2098.2.
Gastrin I, human
Gastrin I, human is the endogenous peptide produced in the stomach, and increases gastric acid secretion via cholecystokinin 2 (CCK2) receptor. Uses: Scientific research. Group: Peptides. CAS No. 10047-33-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1097.
Gastrin I (human) acetate, an endogenous peptide produced by the stomach, is a selective CCK2 receptor agonist that stimulates gastric acid secretion in vivo and increases cytoplasmic calcium levels in isolated rabbit gastric parietal cells (EC50 = 11 nM). Synonyms: Little gastrin I acetate; Gastrin-17 acetate; H-Pyr-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2.CH3CO2H; Gastrin-17 I (human) acetate; 5-Oxo-L-prolylglycyl-L-prolyl-L-tryptophyl-L-leucyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-tyrosylglycyl-L-tryptophyl-L-methionyl-L-α-aspartyl-L-phenylalaninamide acetate; Human gastrin heptadecapeptide I acetate; Human gastrin I (1-17) acetate. Grades: ≥95%. Molecular formula: C99H128N20O33S. Mole weight: 2158.25.
Gastrin II Sulfated
Synonyms: Gastrin I (human) (sulfated); PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR(SO3H)-GLY-TRP-MET-ASP-PHE-NH2. CAS No. 19361-51-4. Molecular formula: C97H124N20O34S2. Mole weight: 2178.27.
Gastrin I rat
Gastrin I can be used to determine the expression of histidine decarboxylase and histamine metabolism. CAS No. 81123-06-0. Molecular formula: C94H128N22O31S2. Mole weight: 2126.28.
Gastrin-Releasing Peptide, human
Gastrin-Releasing Peptide, human (GRP) belongs to the bombesin-like peptide family, and is not a classical hypothalamic-hypophyseal regulatory hormone since it plays only a perfunctory role in the mediation of pituitary hormone release. Uses: Scientific research. Group: Peptides. CAS No. 93755-85-2. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-P0238.
Gastrin-Releasing Peptide, human
Gastrin-Releasing Peptide, human (GRP), one of the bombesin-like peptide family, is an agonist for the gastrin-releasing peptide receptor (GRPR) and it plays only a perfunctory role in the mediation of pituitary hormone release. Synonyms: Gastrin-Releasing Peptide, human; H-Val-Pro-Leu-Pro-Ala-Gly-Gly-Gly-Thr-Val-Leu-Thr-Lys-Met-Tyr-Pro-Arg-Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2. CAS No. 93755-85-2. Molecular formula: C130H204N38O31S2. Mole weight: 2859.38.
Big Gastrin-1, human
Big Gastrin is also referred to as Gastrin-34. Secretion of gastrin is induced by food intake and causes the release of gastric acid in the stomach. Synonyms: Big Gastrin I (human). CAS No. 60675-77-6. Molecular formula: C176H251N43O53S1. Mole weight: 3849.2.
Biotin-Gastrin-1, human (1-17)
Biotin-Gastrin-1, human (1-17) is a biological active peptide. (Biotin-labeled HY-P1097). Uses: Scientific research. Group: Peptides. CAS No. 663625-43-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1097F.
Boc-Trp-Met-Phe amide,des-Asp3-Gastrin related peptide
A derivative of Gastrin I (human), an endogenous peptide produced by stomach and it acts as a selective CCK2 receptor agonist. Synonyms: H-DL-Pyr-Gly-DL-Pro-DL-Trp-DL-Leu-DL-Glu-DL-Glu-DL-Glu-DL-Glu-DL-Glu-DL-Ala-DL-Tyr-Gly-DL-Trp-DL-Leu-DL-Asp-DL-Phe-NH2. Grades: ≥98%. CAS No. 39024-57-2. Molecular formula: C98H126N20O31. Mole weight: 2080.16.
Pentagastrin
A synthetic pentapeptide that mimics endogenous gastrin when given parenterally. It functions via stimulating the secretion of gastric acid, pepsin, and intrinsic factor. Synonyms: AY 6608; ICI 50123; NSC 367746; Boc-(β-Ala13)-Gastrin (13-17); Boc-β-Ala-CCK-4; Peptavlon; D01631. Grades: ≥98%. CAS No. 5534-95-2. Molecular formula: C37H49N7O9S. Mole weight: 767.9.
Tetragastrin
Tetragastrin is a potent releaser of insulin and other islet hormones. Synonyms: Gastrin tetrapeptide; Cholecystokinin tetrapeptide; CCK-4; (S)-4-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino)-3-((S)-2-((S)-2-amino-3-(1H-indol-3-yl)propanamido)-4-(methylthio)butanamido)-4-oxobutanoic acid. CAS No. 1947-37-1. Molecular formula: C29H36N6O6S. Mole weight: 596.71.
2-(2-Fluorophenyl)ethanol
2-(2-Fluorophenyl)ethanol is a useful synthetic intermediate. It is used to prepare phenethyl ester derivative analogs of the C-terminal tetrapeptide of gastrin as potent gastrin antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 50919-06-7. Pack Sizes: 5g, 25 g. Molecular Formula: C8H9FO, Molecular Weight: 140.15. US Biological Life Sciences.
Worldwide
AG-041R
AG-041R is a potent gastrin/CCK2 receptor antagonist that exhibits selective binding for CCK2 compared to CCK1. Synonyms: 1H-Indole-3-acetamide, 1-(2,2-diethoxyethyl)-2,3-dihydro-N-(4-methylphenyl)-3-[[[(4-methylphenyl)amino]carbonyl]amino]-2-oxo-, (+)-; (+)-1-(2,2-Diethoxyethyl)-2,3-dihydro-N-(4-methylphenyl)-3-[[[(4-methylphenyl)amino]carbonyl]amino]-2-oxo-1H-indole-3-acetamide; (+)-AG 041R; AG 041R; (R)-2-(1-(2,2-diethoxyethyl)-2-oxo-3-(3-(p-tolyl)ureido)indolin-3-yl)-N-(p-tolyl)acetamide. Grades: ≥98%. CAS No. 159883-95-1. Molecular formula: C31H36N4O5. Mole weight: 544.64.
Antagonist G
Antagonist G is a substance P analog, which is a broad spectrum neuropeptide growth factor antagonist and antiproliferative agent. It was developed for the treatment of small cell lung cancer. It could inhibit neuropeptide-dependent and -independent proliferation of small cell lung cancer in vitro. It also inhibits growth of SCLC xenografts in mice in vivo. It blocks Swiss 3T3 cell growth induced by vasopressin, gastrin-releasing peptide and bradykinin. It activates JNK and stimulates apoptosis. It is an anticancer agent and is resistant to degradation by peptidases. Synonyms: [Arg6,D-Trp7,9,N-MePhe8]-Substance P(6-11). Grades: 98%. CAS No. 115150-59-9. Molecular formula: C49H66N12O6S. Mole weight: 951.20.
Bombesin
Bombesin, a tetradecapeptide, plays an important role in the release of gastrin and the activation of G-protein receptors [1]. Uses: Scientific research. Group: Peptides. CAS No. 31362-50-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0195.
Bombesin
Bombesin is a neuropeptide with many biological effects such as hormone release, activation of pancreatic enzyme secretion, inhibition of gastric emptying and modulation of gastric acid secretion. It binds to the gastrin-releasing peptide receptor (GRPR) in rat pancreatic acinar cells (Ki = 1.88 nM), and also to frog bombesin receptor subtype 4 (BB4) in CHO cells overexpressing the receptor (Ki = 1.7 nM). Uses: Neurotransmitter agents. Synonyms: H-Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2; L-pyroglutamyl-L-glutaminyl-L-arginyl-L-leucyl-glycyl-L-asparagyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valyl-glycyl-L-histidyl-L-leucyl-L-methioninamide; Glp-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2. Grades: ≥95%. CAS No. 31362-50-2. Molecular formula: C71H110N24O18S. Mole weight: 1619.85.
CCK-4 Acetate
Tetragastrin is a tetrapeptide. Synonyms: CCK-4; CCK4; CCK 4; Gastrin Tetrapeptide; Cholecystokinin Octapeptide (5-8); Cholecystokinin Tetrapeptide; Gastrin (14-17) (human). CAS No. 35144-91-3. Molecular formula: C29H36N6O6S. Mole weight: 596.70.
GRP (porcine)
GRP (porcine) is a mammalian bombesin-like peptide neurotransmitter that acts as an agonist for the gastrin-releasing peptide receptor (GRPR). It was shown to activate GABAergic interneurons in the amygdala resulting in an increase in GABA release and fear suppression in mice in vivo. Synonyms: Gastrin Releasing Peptide porcine. CAS No. 74815-57-9. Molecular formula: C126H198N38O31S2. Mole weight: 2805.31.
L-365,260
L-365,260 is a nonpeptide cholecystokinin receptor 2 (CCK2/CCKB) antagonist. It selectively binds to gastrin and CCK2 sites to reduce basal acid secretion, and prevent gastrointestinal damage in models of peptic ulcer disease. Synonyms: N-[(3R)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)urea. Grades: ≥99% by HPLC. CAS No. 118101-09-0. Molecular formula: C24H22N4O2. Mole weight: 398.46.
Litorin
Litorin is an amphibian bombesin-like peptide. It can stimulate smooth muscle contraction, gastrin release, gastric acid and pancreatic secretion, and suppress food intake in vivo. Synonyms: L-pyroglutamyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valyl-glycyl-L-histidyl-L-phenylalanyl-L-methioninamide. Grades: ≥95%. CAS No. 55749-97-8. Molecular formula: C51H68N14O11S. Mole weight: 1085.25.
Neuromedin C
Neuromedin C (NMC) is a decapeptide that acts as a growth factor in a variety of tumors. Synonyms: Neuromedin C (porcine); Gly-asn-his-trp-ala-val-gly-his-leu-met-NH2; GRP (18-27) (human, porcine, canine); Bombesin decapeptide; Grp-10; Gastrin releasing peptide 10; Canine gastrin-releasing peptide 10; Gastrin releasing peptide (18-27); glycyl-L-asparagyl-L-histidyl-L-tryptophyl-L-alanyl-L-valyl-glycyl-L-histidyl-L-leucyl-L-methioninamide. Grades: ≥95% by HPLC. CAS No. 81608-30-2. Molecular formula: C50H73N17O11S. Mole weight: 1120.29.
N-Methyltyramine
N-Methyltyramine is a protoalkaloid that can be isolated from various plant species. N-Methyltyramine is an α2-adrenoreceptor antagonist. N-Methyltyramine enhances appetite and digestion of foods by stimulating gastrin and pancreatic secretions. N-Methyltyramine can relax mouse small intestinal smooth muscle and inhibits small intestinal propulsion [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 370-98-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-W153897.
PACAP (1-38) free acid
PACAP (1-38) free acid is an endogenous neuropeptide. PACAP (1-38) free acid potently stimulates antral motility and somatostatin secretion, inhibits the secretion of gastrin and stimulates the release of vasoactive intestinal polypeptide, gastrin releasing peptide and substance P. PACAP (1-38) free acid also enhances N-methyl-D-aspartate receptor function and expression of brain-derived neurotrophic factor through RACK1 [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 129405-61-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P0221C.
PD 136450
PD-136,450 is a Cholecystokinin type B receptor antagonist originated by Pfizer. It is a partial secretory agonist in the stomach and a full agonist in the pancreas of the rat. It has therapeutic potential as acid antisecretory drugs, and may be of use as adjuvant therapy for gastrin sensitive tumours. No development for the treatment of Peptic ulcer was reported. Uses: Peptic ulcer. Synonyms: Cam 1189; Cam-1189; Cam1189; PD-136450; PD136450; PD 136450;(E)-4-((2-(2-(((adamantan-2-yloxy)carbonyl)amino)-3-(1H-indol-3-yl)-2-methylpropanamido)-1-phenylethyl)amino)-4-oxobut-2-enoic acid. Grades: 98%. CAS No. 139067-52-0. Molecular formula: C35H40N4O6. Mole weight: 612.72.
PD 176252
PD 176252 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively. PD 176252 inhibits proliferation of rat C6 glioma cells (IC50 = 2 μM) and inhibits NCI-H1299 xenograft proliferation in nude mice (IC50 = 5 μM). Synonyms: (S)-N-[[1-(5-Methoxy-2-pyridinyl)cyclohexyl]methyl]-α-methyl-α-[[[-(4-nitrophenyl)amino]carbonyl]amino-1H-indole-3-propanamide; PD-176252; PD 176252; PD176252. Grades: ≥98% by HPLC. CAS No. 204067-01-6. Molecular formula: C32H36N6O5. Mole weight: 584.67.
YM 022
YM 022 is a highly potent and selective non-peptide CCK2 silent antagonist (Ki = 68 pM and 63 nM at CCK2 and CCK1 receptors, respectively). YM 022 can inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation in vivo with a long duration of action. Synonyms: YM022; YM-022; (R)-N-[2,3-Dihydro-1-[2-(2-methylphenyl)-2-oxoethyl]-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)-urea; N-[(3R)-2,3-Dihydro-1-[2-(2-methylphenyl)-2-oxoethyl]-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)-urea; 3-(3-methylphenyl)-1-[(3R)-1-[2-(2-methylphenyl)-2-oxoethyl]-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]urea. Grades: ≥99% by HPLC. CAS No. 145084-28-2. Molecular formula: C32H28N4O3. Mole weight: 516.59.
Z-360
Z-360 is a selective and orally available 1,5-benzodiazepine-derivative gastrin/cholecystokinin 2 (CCK-2) receptor antagonist with potential antineoplastic activity. Z-360 binds to the gastrin/CCK-2 receptor, thereby preventing receptor activation by gastrin, a peptide hormone frequently associated with the proliferation of gastrointestinal and pancreatic tumor cells. Synonyms: Z-360; Z 360; Z360; Nastorazepide; 3-[[(3R)-1-cyclohexyl-5-(3,3-dimethyl-2-oxobutyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]carbamoylamino]benzoic acid. Grades: > 98%. CAS No. 209219-38-5. Molecular formula: C29H36N4O5. Mole weight: 520.63.
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