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| Product | Description | |
|---|---|---|
| Gefitinib | 100mg Pack Size. Group: Bioactive Small Molecules, Biochemicals, Research Organics & Inorganics. Formula: C22H24ClFN4O3. CAS No. 184475-35-2. Prepack ID 57220562-100mg. Molecular Weight 446.9. See USA prepack pricing. |  |
| Gefitinib | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopyapi standardseuropean pharmacopoeia (ph. eur.)pharmaceutical toxicologypharmacopoeial standards. Alternative Names: N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine, (3-Chloro-4-fluorophenyl)[7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-yl]amine, ZD1839, Gefonib, Iressa, ZD 1839, Gefitinib, 4-(3'-Chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline, 4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline. |  |
| Gefitinib | Gefitinib. CAS No. 184475-35-2. Product ID: 8-04227. Molecular formula: C30H35N7O4S. Mole weight: 589.71. |  |
| Gefitinib | Gefitinib. Group: Biochemicals. Grades: Highly Purified. CAS No. 184475-35-2. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C22H24ClFN4O3. US Biological Life Sciences. |  Worldwide |
| Gefitinib | Gefitinib. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4-Chloro-6-[3-(4-morpholinyl)propoxy]-4-quinazoline;4-Chloro-7-methoxy-6-(3-morpholinopropoxy)quinazoline;4-Chloro-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazoline. Product Category: Heterocyclic Organic Compound. CAS No. 199327-59-8. Molecular formula: C16H20ClN3O3. Mole weight: 0. Product ID: ACM199327598. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Gefitinib | Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC 50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC 50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy and cell apoptosis , which can be used for cancer related research, such as Lung cancer and breast cancer [1] [2] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ZD1839. CAS No. 184475-35-2. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-50895. |  |
| Gefitinib 3,4-Difluoro Impurity HCl | Grades: > 95%. CAS No. 184475-68-1. Molecular formula: C22H25F2N4O3Cl. Mole weight: 466.92. |  |
| Gefitinib 4-Desfluoro Impurity HCl | Grades: > 95%. Molecular formula: C22H26Cl2N4O3. Mole weight: 465.38. | |
| Gefitinib Chloro Impurity | Grades: > 95%. Molecular formula: C16H21Cl2N3O3. Mole weight: 374.27. | |
| Gefitinib-d3 | Labeled Gefitinib. Gefitinib is an antineoplastic. Group: Biochemicals. Alternative Names: N-(3-Chloro-4-fluorophenyl)-7-(methoxy-d3)-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine; Iressa-d3; ZD 1839-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Gefitinib-D6 | Gefitinib-D6. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1228664-49-0. Molecular formula: C22H18D6ClFN4O3. Mole weight: 452.94. Catalog: APB1228664490. | |
| Gefitinib, Free Base (Iressa) | EGFR tyrosine kinase inhibitor that binds to the ATP-binding site of the enzyme. The functions of the EGFR tyrosine kinase in activating the Ras signal transduction cascade and malignant cell growth are thus inhibited. It has been shown that a mutation in the EGFR tyrosine kinase domain is responsible for activating anti-apoptotic pathways in gefitinib-sensitive non-small cell lung cancers. These mutations tend to increase sensitivity to tyrosine kinase inhibitors including gefitinib and erlotinib. The adenocarcinoma subset of non-small cell lung cancer histologies often have these mutations, which are commonly found in Asians, women, and non-smokers. Group: Biochemicals. Grades: Highly Purified. CAS No. 184475-35-2. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| Gefitinib hydrochloride | Gefitinib Hcl(ZD-1839 Hcl) is an EGFR inhibitor, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells. Synonyms: Iressa hydrochloride; ZD 1839 hydrochloride; ZD-1839 hydrochloride; ZD1839 hydrochloride. Grades: >98%. CAS No. 184475-55-6. Molecular formula: C22H25Cl2FN4O3. Mole weight: 483.36. | |
| Gefitinib hydrochloride | Gefitinib hydrochloride (ZD1839 hydrochloride) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC 50 of 33 nM. Gefitinib hydrochloride selectively inhibits EGF-stimulated tumor cell growth (IC 50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib hydrochloride also induces autophagy. Gefitinib hydrochloride has antitumour activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ZD-1839 hydrochloride. CAS No. 184475-55-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-50895A. | |
| Gefitinib Impurity | Cas No. 13794-72-4. | |
| Gefitinib Impurity 1 | Synonyms: 2-Amino-4-methoxy-5-(3-morpholin-4-ylpropoxy)-benzamide. Grades: > 95%. CAS No. 246512-44-7. Molecular formula: C15H23N3O4. Mole weight: 309.37. | |
| Gefitinib Impurity 2 | Cas No. 675126-26-8. | |
| Gefitinib Impurity 3 | Grades: > 95%. Molecular formula: C15H22N2O5. Mole weight: 310.35. | |
| Gefitinib Impurity 34 | Gefitinib Impurity 34. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 3-(3-chloropropoxy)-4-methoxybenzonitrile. CAS No. 1315512-60-7. Molecular formula: C11H12ClNO2. Mole weight: 225.67. Catalog: APB1315512607. | |
| Gefitinib Impurity 35 | Gefitinib Impurity 35. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 5-(3-bromopropoxy)-4-methoxy-2-nitrobenzonitrile. CAS No. 1325726-60-0. Molecular formula: C11H11BrN2O4. Mole weight: 315.12. Catalog: APB1325726600. | |
| Gefitinib Impurity 43 | Gefitinib Impurity 43. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 5-(3-chloropropoxy)-4-methoxy-2-nitrobenzaldehyde. CAS No. 1072107-50-6. Molecular formula: C11H12ClNO5. Mole weight: 273.67. Catalog: APB1072107506. | |
| Gefitinib impurity F | Gefitinib impurity F. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-(3-chloro-4-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine. CAS No. 153437-78-6. Molecular formula: C16H13ClFN3O2. Mole weight: 333.74. Catalog: APB153437786. | |
| Gefitinib Impurity HCl | Synonyms: 3-Deschloro-4-Desfluoro-4-Chloro-3-Fluoro Gefitinib HCl. Grades: > 95%. Molecular formula: C22H25Cl2FN4O3. Mole weight: 483.37. | |
| Gefitinib Impurity I | Grades: > 95%. Molecular formula: C29H37ClFN5O4. Mole weight: 574.10. | |
| Gefitinib Impurity II | Synonyms: N-(3-chloro-4-fluorophenyl)-6 ,7-dimethoxyquinazolin-4-amine. Grades: > 95%. CAS No. 153437-78-6. Molecular formula: C16H13ClFN3O2. Mole weight: 333.75. | |
| Gefitinib Impurity IV | Grades: > 95%. Molecular formula: C22H24Cl2N4O3. Mole weight: 463.37. | |
| Gefitinib impurity K | Gefitinib impurity K. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-methoxy-3-(3-morpholinopropoxy)-2-nitrobenzonitrile. CAS No. 1006378-06-8. Molecular formula: C15H19N3O5. Mole weight: 321.33. Catalog: APB1006378068. | |
| Gefitinib Impurity VI | Gefitinib Impurity VI is Gefitinib intermediate. Synonyms: 4-(3-Chloropropyl)morpholine; 1-Chloro-3-morpholinopropane; 3-(Morpholin-4-yl)propyl Chloride; 3-Chloro-1-(morpholin-4-yl)propane; 3-Morpholinopropyl Chloride; NSC 28831; NSC 38889; N-(3-Chloropropyl)morpholine. Grades: > 95%. CAS No. 7357-67-7. Molecular formula: C7H14ClNO. Mole weight: 163.65. | |
| Gefitinib Impurity VII | An impurity of Gefitinib. Gefitinib is an EGFR inhibitor. It is used for the treatment of certain breast, lung and other cancers. Synonyms: 3,4-Dihydro-4-oxo-6-acetoxy-7-methoxyquinazoline; 6-(Acetyloxy)-7-methoxy-4(3H)-quinazolinone; 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate; Gefitinib interMidiate IV; 7-Methoxy-4-oxo-3,4-dihydroquinazolin-6-yl acetate. Grades: > 95%. CAS No. 179688-53-0. Molecular formula: C11H10N2O4. Mole weight: 234.21. | |
| Gefitinib Impurity VIII | Synonyms: 4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinol 6-acetate; 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate; 6-Quinazolinol,4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-, 6-acetate; Gefitinib intermediate VI. Grades: > 95%. CAS No. 788136-89-0. Molecular formula: C17H13ClFN3O3. Mole weight: 361.76. | |
| Gefitinib Impurity X | Synonyms: 6-Acetoxy-4-chloro-7-methoxyquinazoline; 4-Chloro-6-acetoxy-7-methoxyquinazoline; 4-Chloro-7-methoxy-6-quinazolinol 6-acetate; Gefitinib interMediate V; 6-Quinazolinol, 4-chloro-7-Methoxy-, 6-acetate; N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropox. Grades: > 95%. CAS No. 230955-75-6. Molecular formula: C11H9ClN2O3. Mole weight: 252.66. | |
| Gefitinib (Iressa) | Gefitinib (Iressa). Group: Biochemicals. Alternative Names: Iressa. Grades: Highly Purified. CAS No. 184475-35-2. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| Gefitinib N-Oxide | Gefitinib N-oxide is the N-oxide derivative of Gefitinib. Synonyms: Gefitinib Morpholine N-oxide; N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-oxido-4-morpholinyl)propoxy]-4-quinazolinamine; 4-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)morpholine 4-oxide. Grades: > 95%. CAS No. 847949-51-3. Molecular formula: C22H24ClFN4O4. Mole weight: 462.91. | |
| 3-Desmorpholinyl-3-hydroxyethylamino gefitinib | 3-Desmorpholinyl-3-hydroxyethylamino gefitinib. Group: Biochemicals. Alternative Names: 2- [ [3- [ [4- [ (3-Chloro-4-fluorophenyl) amino] -7-methoxy-6-quinazolinyl] oxy] propyl] amino] ethanol. Grades: Highly Purified. CAS No. 847949-56-8. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C20H22ClFN4O3. US Biological Life Sciences. | Worldwide |
| 3-Desmorpholinyl-3-hydroxyethylamino Gefitinib | 3-Desmorpholinyl-3-hydroxyethylamino Gefitinib is a metabolite of Gefitinib. Synonyms: Ethanol, 2-[[3-[[4-[(3-chloro-4-fluorophenyl)aMino]-7-Methoxy-6-quinazolinyl]oxy]propyl]aMino]-; 2- [ [3- [ [4- [ (3-Chloro-4-fluorophenyl) aMino] -7-Methoxy-6-quinazolinyl] oxy] propyl] aMino] ethanol; Gefitinib iMpurity D; 2-((3-((4-((3-chloro-4-fluorophenyl)amino)-7-. Grades: > 95%. CAS No. 847949-56-8. Molecular formula: C20H22ClFN4O3. Mole weight: 420.87. | |
| 4-Defluoro-4-hydroxy gefitinib | 4-Defluoro-4-hydroxy gefitinib. Group: Biochemicals. Alternative Names: 2-Chloro-4- [ [7-methoxy-6- [3- (4-morpholinyl) propoxy] -4-quinazolinyl] amino] phenol. Grades: Highly Purified. CAS No. 847949-50-2. Pack Sizes: 10mg, 25mg, 50mg, 100mg. Molecular Formula: C22H25ClN4O4. US Biological Life Sciences. | Worldwide |
| 4-Defluoro-4-hydroxy gefitinib | 4-Defluoro-4-hydroxy gefitinib. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-Chloro-4-[[7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenol. Product Category: Heterocyclic Organic Compound. CAS No. 847949-50-2. Molecular formula: C22H25ClN4O4. Mole weight: 444.91. Product ID: ACM847949502. Alfa Chemistry ISO 9001:2015 Certified. | |
| 4-Defluoro-4-hydroxy Gefitinib | 4-Defluoro-4-hydroxy Gefitinib is a metabolite of Gefitinib. Synonyms: 2-Chloro-4-[[7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenol; Phenol, 2-chloro-4-[[7-Methoxy-6-[3-(4-Morpholinyl)propoxy]-4-quinazolinyl]aMino]-; 2-Chloro-4-[[7-Methoxy-6-[3-(4-Morpholinyl)propoxy]-4-quinazolinyl]aMino]phenol; Gefitinib iM. Grades: > 95%. CAS No. 847949-50-2. Molecular formula: C22H25ClN4O4. Mole weight: 444.92. | |
| O-Desmethyl gefitinib | O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC 50 of 36 nM in subcellular assays [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 847949-49-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100064. | |
| O-Desmethyl Gefitinib | A major metabolite of Gefitinib. Group: Biochemicals. Alternative Names: 4-[(3-Chloro-4-fluorophenyl)amino]-6-[3-(4-morpholinyl)propoxy]-7-quinazolinol;M523595. Grades: Highly Purified. CAS No. 847949-49-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| O-Desmethyl Gefitinib | O-Desmethyl Gefitinib is a major metabolite of Gefitinib. Synonyms: 7-Quinazolinol, 4-[(3-Chloro-4-Fluorophenyl)Amino]-6-[3-(4-Morpholinyl)Propoxy]-; 4-[(3-Chloro-4-Fluorophenyl)Amino]-6-[3-(4-Morpholinyl)Propoxy]-7-Quinazolinol; M523595. Grades: > 95%. CAS No. 847949-49-9. Molecular formula: C21H22ClFN4O3. Mole weight: 432.89. | |
| O-Desmorpholinopropyl Gefitinib | A metabolite of Gefitinib. Group: Biochemicals. Alternative Names: 4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinol;4-(3-Chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline. Grades: Highly Purified. CAS No. 184475-71-6. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| O-Desmorpholinopropyl Gefitinib | A metabolite of Gefitinib. Synonyms: O-Desmorpholinopropyl Gefitinib; FAAH-IN-2; FAAH IN 2. Grades: >98%. CAS No. 184475-71-6. Molecular formula: C15H11ClFN3O2. Mole weight: 319.72. | |
| 2-Amino-4-methoxy-5-[3- (4-morpholinyl) propoxy]benzamide | 2-Amino-4-methoxy-5-[3- (4-morpholinyl) propoxy]benzamide is an impurity of Gefitinib; an antineoplastic. Group: Biochemicals. Grades: Highly Purified. CAS No. 246512-44-7. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C15H23N3O4, Molecular Weight: 309.36. US Biological Life Sciences. | Worldwide |
| 2-Amino-4-methoxy-5-[3- (4-morpholinyl) propoxy]benzoic Acid | 2-Amino-4-methoxy-5-[3- (4-morpholinyl) propoxy]benzoic Acid is an impurity of Gefitinib (G304000); an antineoplastic. Group: Biochemicals. Grades: Highly Purified. CAS No. 1640351-46-7. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C15H22N2O5, Molecular Weight: 310.35. US Biological Life Sciences. | Worldwide |
| (2S,5R)-2,5-Dimethylmorpholine | (2S,5R)-2,5-Dimethylmorpholine is a variation of Morpholine (M723725) which is used as selective inhibitors of cytochrome p450 2a13 in treatment of cancer. Morpholine is a building block in the preparation of the antibiotic Linezolid (L466500), the anticancer agent Gefitinib (G304000) and the analgetic Dextromoramide (M630190). Group: Biochemicals. Grades: Highly Purified. CAS No. 1639924-58-5. Pack Sizes: 25mg, 50mg. Molecular Formula: C6H13NO, Molecular Weight: 115.17. US Biological Life Sciences. | Worldwide |
| 3-Chloro-4-fluoroaniline | Gefitinib Impurity V is an organic Fluorinated building block used for the synthesis of pharmaceutical and biologically active compounds. It has antiinflammatory activity. Synonyms: 3-chloro-4-fluoroaniline. Grades: > 95 %. CAS No. 367-21-5. Molecular formula: C6H5ClFN. Mole weight: 145.56. | |
| 4- (3-Chloropropyl) morpholine | Gefitinib intermediate. Group: Biochemicals. Alternative Names: 1-Chloro-3-morpholinopropane; 3-(Morpholin-4-yl)propyl Chloride; 3-Chloro-1-(morpholin-4-yl)propane; 3-Morpholinopropyl Chloride; NSC 28831; NSC 38889. Grades: Highly Purified. CAS No. 7357-67-7. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 4-methoxy-3-(3-morpholinopropoxy)-2-nitrobenzonitrile | 4-methoxy-3-(3-morpholinopropoxy)-2-nitrobenzonitrile is an impurity of Gefitinib. Gefitinib is an antineoplastic drug. Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition. Synonyms: Gefitinib Impurity 17. Grades: 98%. CAS No. 1006378-06-8. Molecular formula: C15H19N3O5. Mole weight: 321.33. | |
| 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzamide | 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzamide is an impurity of Gefitinib. Gefitinib is an antineoplastic drug. Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition. Synonyms: Gefitinib Impurity 22. CAS No. 861453-16-9. Molecular formula: C15H21N3O6. Mole weight: 339.34. | |
| 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin | Gefitinib intermediate. Group: Biochemicals. Alternative Names: 7-Methoxy-6-[3-(4-morpholinyl)propoxy]-. Grades: Highly Purified. CAS No. 199327-61-2. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one | 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one is an intermediate of Gefitinib. Gefitinib is an antineoplastic drug. Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition. Synonyms: Gefitinib Impurity 12; 7-methoxy-6-(3-morpholin-4-ylpropoxy)-1H-quinazolin-4-one. CAS No. 199327-61-2. Molecular formula: C16H21N3O4. Mole weight: 319.36. | |
| Afatinib | Afatinib irreversibly inhibits EGFR/HER2 including EGFR, EGFR(L858R), EGFR(L858R/T790M) and HER2. It is 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. Uses: Antineoplastic agents. Synonyms: 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-; (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide; BIBW 2992; Gilotrif; Giotrif; Tovok; (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide. Grades: >98%. CAS No. 850140-72-6. Molecular formula: C24H25ClFN5O3. Mole weight: 485.94. | |
| AZD-3409 | AZD-3409 is a potent prenyl transferase inhibitor. AZD-3409 showed higher potency than lonafarnib. AZD3409 inhibits farnesylation to a higher extent than geranylgeranylation. AZD3409 might be active in gefitinib-resistant breast carcinoma. Synonyms: AZD-3409; AZD 3409; AZD3409. Grades: 98%. CAS No. 345915-10-8. Molecular formula: C34H41FN4O4S2. Mole weight: 652.844. | |
| Erlotinib mesylate | Erlotinib is an EGFR inhibitor. The drug follows Iressa (gefitinib), which was the first drug of this type. Erlotinib specifically targets the epidermal growth factor receptor (EGFR) tyrosine kinase, which is highly expressed and occasionally mutated in various forms of cancer. It binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. For the signal to be transmitted, two EGFR molecules need to come together to form a homodimer. These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues, which generates phosphotyrosine residues, recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processes. By inhibiting the ATP, formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated. Synonyms: Tarceva; CP-358774; CP 358774; CP358774; OSI-774; OSI 774; OSI774; NSC 718781; NSC718781; NSC-718781; R 1415; R1415; R-1415. Grades: >98%. CAS No. 248594-19-6. Molecular formula: C23H27N3O7S. Mole weight: 489.54. | |
| Gambogic Acid | Gambogic Acid is an apoptosis inducer in sever tumor cell lines via regulation of Bax and inhibition of Bcl-2 genes. Induces EGFR degredation through AMPK dependant-LRIG1 upregulation in glioma cells. Apoptosis inducer in several tumor cell lines including T47D cells. Activates caspases (EC50 values are 0.78 - 1.64uM) and competitively inhibits antiapoptotic Bcl-2 family proteins (IC50 values are 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79uM for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 respectively). Reverses gefitinib-resistance in mice bearing tumors with EGFR-T790M mutation. Also blocks Kir2.1 channels (EC50 ≤100nM). Group: Biochemicals. Alternative Names: (2Z)-2-Methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-butenoic acid. Grades: Purified. CAS No. 2752-65-0. Pack Sizes: 10mg, 50mg. Molecular Formula: C38H44O8, Molecular Weight: 628.75. US Biological Life Sciences. | Worldwide |
| Morpholine | Morpholine, is used as selective inhibitors of cytochrome p450 2a13 in treatment of cancer. Morpholine is a building block in the preparation of the antibiotic Linezolid (L466500), the anticancer agent Gefitinib (G304000) and the analgetic Dextromoramide (M630190). Group: Biochemicals. Grades: Highly Purified. CAS No. 110-91-8. Pack Sizes: 10ml, 25ml. Molecular Formula: C4H9NO. US Biological Life Sciences. | Worldwide |
| Nrf2-IN-3 | Nrf2-IN-3 (Compound R16) is a small-molecule NRF2 inhibitor and increases reactive oxygen species (ROS) production. Nrf2-IN-3 selectively binds KEAP1 mutants and restores their NRF2-inhibitory function by repairing the disrupted KEAP1/NRF2 interactions, leading to proteasome-dependent NRF2 degradation in cells. Nrf2-IN-3 sensitizes KEAP1-mutated tumor cells to Cisplatin (HY-17394), Gefitinib (HY-50895), and KEAP1 G333C-mutated xenograft to Cisplatin [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 6325-13-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149508. | |
| Peruvoside | Peruvoside is a potent inhibitor of Src , PI3K , JNK , STAT , and EGFR. Peruvoside induces apoptosis and autophagy and possesses a broad spectrum of anticancer activity in breast, lung, liver cancers and leukemia. Peruvoside is a broad-spectrum and potent antiviral activity against positive-sense RNA viruses. Peruvoside sensitizes Gefitinib (HY-50895)-resistant tumour cells (A549, PC9/gef and H1975) to Gefitinib [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Encordin. CAS No. 1182-87-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-108016. | |
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