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| Product | Description | |
|---|---|---|
| Geldanamycin | 10mg Pack Size. Group: Antibiotics, Bioactive Small Molecules, Research Organics & Inorganics. Formula: C29H40N2O9. CAS No. 30562-34-6. Prepack ID 48834712-10mg. Molecular Weight 560.64. See USA prepack pricing. |  |
| Geldanamycin | Geldanamycin is a Hsp90 inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria. Geldanamycin has anti-influenza virus H5N1 activities. Uses: Scientific research. Group: Natural products. CAS No. 30562-34-6. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15230. |  |
| Geldanamycin (Streptomyces hygroscopicus) 98+% | Geldanamycin is benzoquinone ansamycin antibiotic isolated from Streptomyces hygroscopicus. A potent antitumor 1 and potent inhibitor of p60c-crc tyrosine kinase, erb B2,2 EGF receptor tyrosine kinase and non-receptor tyrosine kinases. 3, Geldanamycin binds specifically and inhibits the chaperone protein Hsp90.2. Group: Biochemicals. Alternative Names: 9, 13-Dihydroxy-8, 14, 19-trimethoxy-4, 10, 12, 16-tetramethyl-2-azabicyclo[16. 3. 1]docosa-4, 6, 10, 18, 21-pentaene-3, 20, 22-trione 9-Carbamate; (+)-Geldanamycin; NSC 122750; NSC 212518; BRN1633093. Grades: Highly Purified. CAS No. 30562-34-6. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Geldanamycin (Streptomyces hygroscopicus) 99+% | Geldanamycin binds specifically to heat shock protein HSP90; inhibits protein maturation. Group: Biochemicals. Alternative Names: 9, 13-Dihydroxy-8, 14, 19-trimethoxy-4, 10, 12, 16-tetramethyl-2-azabicyclo[16. 3. 1]docosa-4, 6, 10, 18, 21-pentaene-3, 20, 22-trione 9-Carbamate; (+)-Geldanamycin; NSC 122750; NSC 212518; BRN1633093. Grades: Highly Purified. CAS No. 30562-34-6. Pack Sizes: 1mg, 25mg, 100mg, 250mg, 1g. US Biological Life Sciences. | Worldwide |
| 17-AAG (17-allylamino-17-demethoxygeldanamycin, Telatinib, Tanespimycin, NSC-330507, CNF-101, KOS-953, GLD-36, CP 127374) | Semi-synthetic derivative of geldanamycin, demonstrating greater stability and lower in vivo toxicity than its parent compound. 17-AAG binds specifically to heat shock protein Hsp90 in a manner similar to geldanamycin, but the binding is weaker. Group: Biochemicals. Grades: Highly Purified. CAS No. 75747-14-7. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| 17-(Allylamino-d5) Geldanamycin | Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. Group: Biochemicals. Alternative Names: 17-Demethoxy-17-(2-propenylamino-d5)geldanamycin; 17-(Allylamino-d5)-17-demethoxygeldanamycin; 17-(Allylamino-d5)-17-desmethylgeldanamycin; 17-Demethoxy-17-(allylamino-d5)geldanamycin; 17AAG-d5; CP 127374-d5; KOS 953-d5; NSC 330507-d5; Tanespimycin-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 17-(Allylamino) Geldanamycin | Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. Group: Biochemicals. Alternative Names: 17-Demethoxy-17- (2-propenylamino) geldanamycin; 17-(Allylamino)-17-demethoxygeldanamycin; 17-(Allylamino)-17-desmethylgeldanamycin; 17-Demethoxy-17-allyl aminogeldanamycin; 17AAG; CP 127374; KOS 953; NSC 330507; Tanespimycin; 17-AAG. Grades: Highly Purified. CAS No. 75747-14-7. Pack Sizes: 1mg, 10mg, 25mg, 100mg. Molecular Formula: C31H43N3O8, Molecular Weight: 585.69. US Biological Life Sciences. | Worldwide |
| 17-Amino Geldanamycin | The active metabolite of 17- (Allylamino) geldanamycin (17AAG). Group: Biochemicals. Alternative Names: 17-Amino-17-demethoxygeldanamycin; 17-Aminogeldanamycin; NSC 255109; 17AG. Grades: Highly Purified. CAS No. 64202-81-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 17-Amino Geldanamycin-13C,15N2 | The labeled active metabolite of 17- (Allylamino) geldanamycin (17AAG). Group: Biochemicals. Alternative Names: 17-Amino-17-demethoxygeldanamycin-13C,15N2; 17-Aminogeldanamycin-13C,15N2; NSC 255109-13C,15N2; 17AG-13C,15N2. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 17-DMAG (NSC 707545, 17- [2-(Di methyl amino) et hyl ] amino-17-desmethoxygeldanamycin ) | Less toxic, more potent synthetic derivative of geldanamycin. Angiogenesis inhibitor. Heat shock protein 90 (HSP90) inhibitor. Apoptosis inducer. Shows higher antitumor activity than 17-AAG. Group: Biochemicals. Grades: Highly Purified. CAS No. 467214-20-6. Pack Sizes: 100ug, 1mg. US Biological Life Sciences. | Worldwide |
| 17-N- (2-Di methyl aminoethylamino) -17-demethoxy Geldanamycin Hydrochloride | 17-DMAG is an analogue of Gelamycin and 17- (Allylamino) geldanamycin. 17-DMAG acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG. Group: Biochemicals. Alternative Names: 17-Demethoxy-17- [ [2- (dimethylamino) ethyl] amino] geldanamycin Hydrochloride; 17-N- (2-Di methyl aminoethylamino) -17-demethoxygeldanamycin Hydrochloride; 17-[2- (Dimethylamino) ethylamino]-17-desmethylgeldanamycin Hydrochloride; Alvespimycin Hydrochloride; DMAG Hydrochloride; NSC 707545 Hydrochloride; 17-DMAG Hydrochloride. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| 7-Descarbamoyl 17-Amino Geldanamycin | An intermediate in the preparation of 17- (Allylamino) geldanamycin (17AAG) metabolites. Group: Biochemicals. Alternative Names: 17-Amino-7-O-de(aminocarbonyl)-17-demethoxy-geldanamycin; 17-Amino-7-decarbamoyl Geldanamycin. Grades: Highly Purified. CAS No. 169564-26-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 7-Descarbamoyl 17-Amino Geldanamycin-15N | An intermediate in the preparation of labeled 17- (Allylamino) geldanamycin (17AAG) metabolites. Group: Biochemicals. Alternative Names: 17-Amino-7-O-de(aminocarbonyl)-17-demethoxy-geldanamycin-15N; 17-Amino-7-decarbamoyl Geldanamycin-15N. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Aminohexylgeldanamycin | Aminohexylgeldanamycin (AHGDM), a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin shows antiangiogenic and antitumor activities [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AHGDM. CAS No. 485395-71-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-133571. | |
| Herbimycin A (Antibiotic TAN 420F, (15R)-17-Demethoxy-15-methoxy-11-O-methyl-geldanamycin) | Benzoquinone ansamycin antibiotic. Herbicidal compound. Potent, selective, irreversible and cell permeable protein tyrosine kinase inhibitor. Inhibitor of v-Src, Yes, Fps, Ros, Bcr-Abl and ErbB oncogene products. Antitumor compound. Antiangiogenic. Inhibits NF-kappaB activation and phosphorylation of phospholipase C-gamma1. Inhibitor of heat shock protein 90 (Hsp90). Binds Hsp90 and destabilizes client proteins leading to their ubiquitination and proteasomal degradation. Increases the sensitivity of certain cancer cells to chemotherapeutic agents. Neuroprotective. Antiparasitic, antischistosomal agent. Antiviral. Increase microtubules sensitivity to cold in plants. Group: Biochemicals. Grades: Highly Purified. CAS No. 70563-58-5. Pack Sizes: 100ug, 1mg. Molecular Formula: C30H42N2O9. US Biological Life Sciences. | Worldwide |
| 17-AAG | 17-AAG is an antibiotic with antineoplastic activity that inhibits heat shock protein 90 (HSP90). It was shown to induce apoptosis of mouse lymphoma cancer stem cells (CSCs) and human acute myeloid leukemia (AML) CSCs. Synonyms: Tanespimycin; 17-Allylaminogeldanamycin; BAY 579352; 17-(Allylamino) Geldanamycin; 17-Demethoxy-17-(2-propenylamino)geldanamycin; 17-(Allylamino)-17-demethoxygeldanamycin; 17-Demethoxy-17-allylaminogeldanamycin; CP 127374; NSC 330507; Tanespimycin; 17AAG. Grades: >98%. CAS No. 75747-14-7. Molecular formula: C31H43N3O8. Mole weight: 585.69. |  |
| 17-AAG | Potent, less toxic analog of geldanamycin. Inhibits the essential ATPase activity of HSP90. Telomerase activity inhibitor. Apoptosis inducer and antitumor compound. Group: Biochemicals. Grades: Highly Purified. CAS No. 75747-14-7. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| 17-AG | An orally bioavailable formulation of the ansamycin derivative 17-amino-17-demethoxygeldanamycin (17-AG) with potential antineoplastic activity. Oral Hsp90 inhibitor IPI-493 binds to and inhibits Hsp90, which may result the in growth inhibition in sensitive tumor cell populations. Synonyms: 17 AG; 17AG; 17-AG; IPI493; IPI 493; IPI-493; NSC 255109; NSC255109; NSC-255109; 17-Aminogeldanamycin; 17-Amino Geldanamycin; 17-Aminodemethoxygeldanamycin; 17-Amino-17-demethoxygeldanamycin. Grades: >98%. CAS No. 64202-81-9. Molecular formula: C28H39N3O8. Mole weight: 545.62. | |
| 17-DMAG | 17-DMAG is a synthetic Geldanamycin derivative and inhibitor of Hsp90. Group: Biochemicals. Grades: Highly Purified. CAS No. 467214-20-6. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C32H48N4O8, Molecular Weight: 616.75. US Biological Life Sciences. | Worldwide |
| 17-DMAG hydrochloride | 17-DMAG hydrochloride (Alvespimycin hydrochloride) is the hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to Hsp90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. Synonyms: 17-DMAG HCl; Alvespimycin HCl; 17-Dimethylaminoethylamino-17-demethoxygeldanamycin Hydrochloride; 17-N-(2-Dimethylaminoethylamino)-17-demethoxy Geldanamycin Hydrochloride; 17-Demethoxy-17-[[2- (dimethylamino) ethyl]amino]geldanamycin Hydrochloride; 17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin Hydrochloride; Alvespimycin Hydrochloride; DMAG Hydrochloride; NSC 707545 Hydrochloride; 17-DMAG Hydrochloride. Grades: >98%. CAS No. 467214-21-7. Molecular formula: C32H48N4O8.HCl. Mole weight: 653.21. | |
| 1-Azetidineethanamine | 1-Azetidineethanamine is a reagent used in the synthesis of analogs of geldanamycin with superior inhibition ability towards the growth of human cancer cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 795299-77-3. Pack Sizes: 250mg, 500mg. Molecular Formula: C5H12N2, Molecular Weight: 100.16. US Biological Life Sciences. | Worldwide |
| (3-Benzyloxypropyl) triphenylphosphonium Bromide | (3-Benzyloxypropyl) triphenylphosphonium Bromide is a reagent used in the preparation of antitumor and Her2 degradation activity of geldanamycin and radicicol macrocyclic chimeras. Group: Biochemicals. Grades: Highly Purified. CAS No. 54314-85-1. Pack Sizes: 1g, 10g. Molecular Formula: C28H28BrOP, Molecular Weight: 491.4. US Biological Life Sciences. | Worldwide |
| β-Pyrazofurin | Geldanamycin derivative. Group: Biochemicals. Alternative Names: 4-Hydroxy-3- β-D-ribofuranosyl-1H-pyrazole-5-carboxamide; Antibiotic A 23813; NSC 143095; Pirazofurin; Przf; Pyrazofurin; Pyrazomycin; Pyrozofurin; β-Pyrazomycin. Grades: Highly Purified. CAS No. 30868-30-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Herbimycin B | It is produced by the strain of Streptomyces hygroscopicus. It is an ansamycin antibiotic that acts as a Src family kinase inhibitor. It has herbicidal effect on most monocotyledons and dicotyledons, inhibits the activity of tobacco Mosaic virus (TMV), HeLa cells and Ehrlich cells. Synonyms: Geldanamycin, 17-demethoxy-. Grades: ≥95%. CAS No. 76207-83-5. Molecular formula: C28H38N2O8. Mole weight: 530.61. | |
| Herbimycin C | Herbimycin C is a minor analogue of the herbimycin complex isolated from Streptomyces hygroscopicus. Herbimycin C possesses potent antitumor activity and converts Rous sarcoma virus-infected rat kidney cells into normal cells. Until now limited access has restricted a full investigation of the properties of herbimycin C. Research on related metabolites, herbimycin A and geldanamycin, has stimulated intensive interest in this class as selective antitumor agents and for prolonging the viability of tissue-cultured cells and organs. Group: Pheromone ingredients. CAS No. 91700-92-4. Molecular formula: C29H40N2O9. Mole weight: 560.6. Appearance: yellow solid. Purity: 0.98. Catalog: ACM91700924. |  |
| Herbimycin C | It is produced by the strain of Streptomyces hygroscopicus. It is an ansamycin antibiotic that acts as a Src family kinase inhibitor. It has herbicidal effect on most monocotyledons and dicotyledons, inhibits the activity of tobacco Mosaic virus (TMV), HeLa cells and Ehrlich cells. Synonyms: Geldanamycin, 17-demethoxy-15-methoxy-, (15R)-. Grades: >98% by HPLC. CAS No. 91700-92-4. Molecular formula: C29H40N2O9. Mole weight: 560.64. | |
| Herbimycin C (Antibiotic TAN 420D) | Herbimycin C is a minor analogue of herbimycin complex isolated from Streptomyces hygroscopicus. Herbimycin C possesses potent antitumor activity and has been shown to convert Rous sarcoma virus-infected rat kidney cells into normal cells. Until now limited access has restricted a full investigation of the properties of herbimycin C. Research on related metabolites, herbimycin A and geldanamycin has stimulated intensive interest in this class as selective antitumor agents and for prolonging the viability of tissue-cultured cells and organs. Group: Biochemicals. Alternative Names: Antibiotic TAN 420D. Grades: Highly Purified. CAS No. 91700-92-4. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Macbecin I | Macbecin I is an ansamycin antibiotic compound that inhibits Hsp90 by binding to the ATP-binding site (IC50 = 2μM). It exhibits antitumor and cytocidal activities (IC50~ 0.4 μM) by causing degradation of key oncogenic client proteins such as ErbB2 and cRaf1. It exhibits higher affinity and potency than geldanamycin. Grades: >98%. CAS No. 73341-72-7. Molecular formula: C30H42N2O8. Mole weight: 558.67. | |
| Ratester | Radester is a hybrid composed of radicicol's resorcinol and geldanamycin's benzoquinone part structures and exhibits good cellular activity against MCF7 breast cancer cells, accompanied by degradation of the Hsp90 clients HER-2 and c-Raf. Synonyms: CHEMBL578372; CHEMBL 578372; CHEMBL-578372; SCHEMBL10186763; SCHEMBL 10186763; SCHEMBL-10186763. Grades: >98%. CAS No. 854485-83-9. Molecular formula: C18H16ClNO8. Mole weight: 409.77. | |
| Reblastatin | Reblastatin is an Ansa antibiotic produced by Streptomyces hygroscopicus subsp. hygroscopicus SANK 61995 and is a reduction product of Geldanamycin. It is a cell cycle inhibitor that can inhibit cell proliferation. The IC50 for human mesenchymal lymphoma U-93 is 0.43 μg/mL, and the reference geldanamycin is 0.0011 μg/mL. Molecular formula: C29H44N2O8. Mole weight: 548.67. | |
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