Geldanamycin Suppliers USA
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Product | Description | |
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Geldanamycin Quick inquiry Where to buy Suppliers range | Geldanamycin is an ansamycin consisting of a 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria. It has a role as an antiviral agent, an antineoplastic agent, an antimicrobial agent, a cysteine protease inhibitor and a Hsp90 inhibitor. Uses: Microbial Fermentation Products. CAS No. 30562-34-6. Product ID: MFP-021. | |
Geldanamycin Quick inquiry Where to buy Suppliers range | Geldanamycin. CAS No. 30562-34-6. Categories: Geldanamycin. | |
Geldanamycin Quick inquiry Where to buy Suppliers range | 10mg Pack Size. Group: Antibiotics, Bioactive Small Molecules, Research Organics & Inorganics. Formula: C29H40N2O9. CAS No. 30562-34-6. Prepack ID 48834712-10mg. Molecular Weight 560.64. See USA prepack pricing. | |
Geldanamycin (Streptomyces hygroscopicus) 98+% Quick inquiry Where to buy Suppliers range | Geldanamycin is benzoquinone ansamycin antibiotic isolated from Streptomyces hygroscopicus. A potent antitumor 1 and potent inhibitor of p60c-crc tyrosine kinase, erb B2,2 EGF receptor tyrosine kinase and non-receptor tyrosine kinases. 3, Geldanamycin binds specifically and inhibits the chaperone protein Hsp90.2. Group: Biochemicals. Alternative Names: 9, 13-Dihydroxy-8, 14, 19-trimethoxy-4, 10, 12, 16-tetramethyl-2-azabicyclo[16. 3. 1]docosa-4, 6, 10, 18, 21-pentaene-3, 20, 22-trione 9-Carbamate; (+)-Geldanamycin; NSC 122750; NSC 212518; BRN1633093. Grades: Highly Purified. CAS No. 30562-34-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Geldanamycin (Streptomyces hygroscopicus) 99+% Quick inquiry Where to buy Suppliers range | Geldanamycin binds specifically to heat shock protein HSP90; inhibits protein maturation. Group: Biochemicals. Alternative Names: 9, 13-Dihydroxy-8, 14, 19-trimethoxy-4, 10, 12, 16-tetramethyl-2-azabicyclo[16. 3. 1]docosa-4, 6, 10, 18, 21-pentaene-3, 20, 22-trione 9-Carbamate; (+)-Geldanamycin; NSC 122750; NSC 212518; BRN1633093. Grades: Highly Purified. CAS No. 30562-34-6. Pack Sizes: 1mg, 25mg, 100mg, 250mg, 1g. US Biological Life Sciences. | Worldwide |
17-(Allylamino-d5) Geldanamycin Quick inquiry Where to buy Suppliers range | Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. Group: Biochemicals. Alternative Names: 17-Demethoxy-17-(2-propenylamino-d5)geldanamycin; 17-(Allylamino-d5)-17-demethoxygeldanamycin; 17-(Allylamino-d5)-17-desmethylgeldanamycin; 17-Demethoxy-17-(allylamino-d5)geldanamycin; 17AAG-d5; CP 127374-d5; KOS 953-d5; NSC 330507-d5; Tanespimycin-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
17-(Allylamino) Geldanamycin Quick inquiry Where to buy Suppliers range | Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. Group: Biochemicals. Alternative Names: 17-Demethoxy-17- (2-propenylamino) geldanamycin; 17-(Allylamino)-17-demethoxygeldanamycin; 17-(Allylamino)-17-desmethylgeldanamycin; 17-Demethoxy-17-allyl aminogeldanamycin; 17AAG; CP 127374; KOS 953; NSC 330507; Tanespimycin; 17-AAG. Grades: Highly Purified. CAS No. 75747-14-7. Pack Sizes: 1mg, 10mg, 25mg, 100mg. Molecular Formula: C31H43N3O8, Molecular Weight: 585.69. US Biological Life Sciences. | Worldwide |
17-(Allylamino) Geldanamycin Quick inquiry Where to buy Suppliers range | 17-(Allylamino) Geldanamycin. Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates. CAS No. 75747-14-7. IUPAC Name: [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate. Molecular formula: C31H43N3O8. Mole weight: 585.69. Catalog: APS75747147. SMILES: CO[C@H]1C[C@H] (C)CC2=C (NCC=C)C (=O)C=C (NC (=O)\C (=C\C=C/[C@H] (OC)[C@@H] (OC (=O)N)\C (=C\[C@H] (C)[C@H]1O)\C)\C)C2=O. Format: Neat. | |
17-Amino Geldanamycin Quick inquiry Where to buy Suppliers range | The active metabolite of 17- (Allylamino) geldanamycin (17AAG). Group: Biochemicals. Alternative Names: 17-Amino-17-demethoxygeldanamycin; 17-Aminogeldanamycin; NSC 255109; 17AG. Grades: Highly Purified. CAS No. 64202-81-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
17-Amino Geldanamycin-13C,15N2 Quick inquiry Where to buy Suppliers range | The labeled active metabolite of 17- (Allylamino) geldanamycin (17AAG). Group: Biochemicals. Alternative Names: 17-Amino-17-demethoxygeldanamycin-13C,15N2; 17-Aminogeldanamycin-13C,15N2; NSC 255109-13C,15N2; 17AG-13C,15N2. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
17-N- (2-Di methyl aminoethylamino) -17-demethoxy Geldanamycin Hydrochloride Quick inquiry Where to buy Suppliers range | 17-DMAG is an analogue of Gelamycin and 17- (Allylamino) geldanamycin. 17-DMAG acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG. Group: Biochemicals. Alternative Names: 17-Demethoxy-17- [ [2- (dimethylamino) ethyl] amino] geldanamycin Hydrochloride; 17-N- (2-Di methyl aminoethylamino) -17-demethoxygeldanamycin Hydrochloride; 17-[2- (Dimethylamino) ethylamino]-17-desmethylgeldanamycin Hydrochloride; Alvespimycin Hydrochloride; DMAG Hydrochloride; NSC 707545 Hydrochloride; 17-DMAG Hydrochloride. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
7-Descarbamoyl 17-Amino Geldanamycin Quick inquiry Where to buy Suppliers range | An intermediate in the preparation of 17- (Allylamino) geldanamycin (17AAG) metabolites. Group: Biochemicals. Alternative Names: 17-Amino-7-O-de(aminocarbonyl)-17-demethoxy-geldanamycin; 17-Amino-7-decarbamoyl Geldanamycin. Grades: Highly Purified. CAS No. 169564-26-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
7-Descarbamoyl 17-Amino Geldanamycin-15N Quick inquiry Where to buy Suppliers range | An intermediate in the preparation of labeled 17- (Allylamino) geldanamycin (17AAG) metabolites. Group: Biochemicals. Alternative Names: 17-Amino-7-O-de(aminocarbonyl)-17-demethoxy-geldanamycin-15N; 17-Amino-7-decarbamoyl Geldanamycin-15N. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Herbimycin A (Antibiotic TAN 420F, (15R)-17-Demethoxy-15-methoxy-11-O-methyl-geldanamycin) Quick inquiry Where to buy Suppliers range | Benzoquinone ansamycin antibiotic. Herbicidal compound. Potent, selective, irreversible and cell permeable protein tyrosine kinase inhibitor. Inhibitor of v-Src, Yes, Fps, Ros, Bcr-Abl and ErbB oncogene products. Antitumor compound. Antiangiogenic. Inhibits NF-kappaB activation and phosphorylation of phospholipase C-gamma1. Inhibitor of heat shock protein 90 (Hsp90). Binds Hsp90 and destabilizes client proteins leading to their ubiquitination and proteasomal degradation. Increases the sensitivity of certain cancer cells to chemotherapeutic agents. Neuroprotective. Antiparasitic, antischistosomal agent. Antiviral. Increase microtubules sensitivity to cold in plants. Group: Biochemicals. Grades: Highly Purified. CAS No. 70563-58-5. Pack Sizes: 100ug, 1mg. Molecular Formula: C30H42N2O9. US Biological Life Sciences. | Worldwide |
17-AAG Quick inquiry Where to buy Suppliers range | 17-AAG is an antibiotic with antineoplastic activity that inhibits heat shock protein 90 (HSP90). It was shown to induce apoptosis of mouse lymphoma cancer stem cells (CSCs) and human acute myeloid leukemia (AML) CSCs. Synonyms: Tanespimycin; 17-Allylaminogeldanamycin; BAY 579352; 17-(Allylamino) Geldanamycin; 17-Demethoxy-17-(2-propenylamino)geldanamycin; 17-(Allylamino)-17-demethoxygeldanamycin; 17-Demethoxy-17-allylaminogeldanamycin; CP 127374; NSC 330507; Tanespimycin; 17AAG. Grades: >98%. CAS No. 75747-14-7. Molecular formula: C31H43N3O8. Mole weight: 585.69. | |
17-AAG Quick inquiry Where to buy Suppliers range | Potent, less toxic analog of geldanamycin. Inhibits the essential ATPase activity of HSP90. Telomerase activity inhibitor. Apoptosis inducer and antitumor compound. Group: Biochemicals. Grades: Highly Purified. CAS No. 75747-14-7. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
17-AAG (17-allylamino-17-demethoxygeldanamycin, Telatinib, Tanespimycin, NSC-330507, CNF-101, KOS-953, GLD-36, CP 127374) Quick inquiry Where to buy Suppliers range | Semi-synthetic derivative of geldanamycin, demonstrating greater stability and lower in vivo toxicity than its parent compound. 17-AAG binds specifically to heat shock protein Hsp90 in a manner similar to geldanamycin, but the binding is weaker. Group: Biochemicals. Grades: Highly Purified. CAS No. 75747-14-7. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
17-AG Quick inquiry Where to buy Suppliers range | An orally bioavailable formulation of the ansamycin derivative 17-amino-17-demethoxygeldanamycin (17-AG) with potential antineoplastic activity. Oral Hsp90 inhibitor IPI-493 binds to and inhibits Hsp90, which may result the in growth inhibition in sensitive tumor cell populations. Synonyms: 17 AG; 17AG; 17-AG; IPI493; IPI 493; IPI-493; NSC 255109; NSC255109; NSC-255109; 17-Aminogeldanamycin; 17-Amino Geldanamycin; 17-Aminodemethoxygeldanamycin; 17-Amino-17-demethoxygeldanamycin. Grades: >98%. CAS No. 64202-81-9. Molecular formula: C28H39N3O8. Mole weight: 545.62. | |
17-Dmag Quick inquiry Where to buy Suppliers range | 17-Dmag. Group: Heterocyclic Organic Compound. Alternative Names: 17-DIMETHYLAMINOETHYLAMINO-17-DEMETHOXY-GELDANAMYCIN; 17-DIMETHYLAMINOGELDANAMYCIN; Alvespimycin hydrochloride;BMS 826476;KOS 1022;AlvespiMycin hydrochloride(17-DMAG,BMS 826476;17-DMAG HCl (AlvespiMycin);17-DMAG (AlvespiMycin) HCl. CAS No. 467214-21-7. Molecular formula: C32H48N4O8. Mole weight: 616.75. | |
17-DMAG Quick inquiry Where to buy Suppliers range | 17-DMAG is a synthetic Geldanamycin derivative and inhibitor of Hsp90. Group: Biochemicals. Grades: Highly Purified. CAS No. 467214-20-6. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C32H48N4O8, Molecular Weight: 616.75. US Biological Life Sciences. | Worldwide |
17-DMAG hydrochloride Quick inquiry Where to buy Suppliers range | 17-DMAG hydrochloride (Alvespimycin hydrochloride) is the hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to Hsp90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. Synonyms: 17-DMAG HCl; Alvespimycin HCl; 17-Dimethylaminoethylamino-17-demethoxygeldanamycin Hydrochloride; 17-N-(2-Dimethylaminoethylamino)-17-demethoxy Geldanamycin Hydrochloride; 17-Demethoxy-17-[[2- (dimethylamino) ethyl]amino]geldanamycin Hydrochloride; 17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin Hydrochloride; Alvespimycin Hydrochloride; DMAG Hydrochloride; NSC 707545 Hydrochloride; 17-DMAG Hydrochloride. Grades: >98%. CAS No. 467214-21-7. Molecular formula: C32H48N4O8.HCl. Mole weight: 653.21. | |
17-DMAG (NSC 707545, 17- [2-(Di methyl amino) et hyl ] amino-17-desmethoxygeldanamycin ) Quick inquiry Where to buy Suppliers range | Less toxic, more potent synthetic derivative of geldanamycin. Angiogenesis inhibitor. Heat shock protein 90 (HSP90) inhibitor. Apoptosis inducer. Shows higher antitumor activity than 17-AAG. Group: Biochemicals. Grades: Highly Purified. CAS No. 467214-20-6. Pack Sizes: 100ug, 1mg. US Biological Life Sciences. | Worldwide |
1-Azetidineethanamine Quick inquiry Where to buy Suppliers range | 1-Azetidineethanamine is a reagent used in the synthesis of analogs of geldanamycin with superior inhibition ability towards the growth of human cancer cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 795299-77-3. Pack Sizes: 250mg, 500mg. Molecular Formula: C5H12N2, Molecular Weight: 100.16. US Biological Life Sciences. | Worldwide |
(3-Benzyloxypropyl) triphenylphosphonium Bromide Quick inquiry Where to buy Suppliers range | (3-Benzyloxypropyl) triphenylphosphonium Bromide is a reagent used in the preparation of antitumor and Her2 degradation activity of geldanamycin and radicicol macrocyclic chimeras. Group: Biochemicals. Grades: Highly Purified. CAS No. 54314-85-1. Pack Sizes: 1g, 10g. Molecular Formula: C28H28BrOP, Molecular Weight: 491.4. US Biological Life Sciences. | Worldwide |
Alvespimycin Quick inquiry Where to buy Suppliers range | Alvespimycin (17-DMAG; KOS-1022; NSC 707545) is a potent, water-soluble Hsp90 inhibitor with IC50 of 62 nM. 17-DMAG displays ~2 times potency against human Hsp90 than 17-AAG, with IC50 of 62 nM versus 119 nM. In SKBR3 and SKOV3 cells which overexpress Hsp90 client protein Her2, 17-DMAG causes down-regulation of Her2 with EC50 of 8 nM and 46 nM, respectively, as well as induction of Hsp70 with EC50 of 4 nM and 14 nM, respectively, leading to significant cytotoxicity with GI50 of 29 nM and 32 nM, respectively, consistent with Hsp90 inhibition. In combination with vorinostat, 17-DMAG synergistically induces apoptosis of the cultured MCL cells as well as primary MCL cells, more potently than either agent alone, by markedly attenuating the levels of cyclin D1 and CDK4, as well as of c-Myc, c-RAF and Akt. 17-DMAG treatment at 5 mg/kg or 25 mg/kg three times per week significantly reduces tumor growth of TMK-1 xenografts, by reducing vessel area and numbers of proliferating tumor cells in sections. Consistent the inhibition of FAK signaling in vivo, 17-DMAG treatment at 25 mg/kg three times a week significantly suppresses tumor growth, and metastasis of ME180 and SiHa xenografts in mice. Administration of 17-DMAG at 10 mg/kg for 16 days significantly decreases the white blood cell count and prolongs the survival in a TCL1-SCID transplant mouse model. Uses: Hsp-90 inhibitor; potential anti-cancer drug. Synonyms: 17-DMAG; KOS 1022; KOS-1022; KOS1022; 17-DMAGhydrochloride; 17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin; 17-Demethoxy-17-[[2- (dimethylamino) ethyl]amino]geldanamycin. Grades: >98%. CAS No. 467214-20-6. Molecular formula: C32H48N4O8. Mole weight: 616.75. | |
β-Pyrazofurin Quick inquiry Where to buy Suppliers range | Geldanamycin derivative. Group: Biochemicals. Alternative Names: 4-Hydroxy-3- β-D-ribofuranosyl-1H-pyrazole-5-carboxamide; Antibiotic A 23813; NSC 143095; Pirazofurin; Przf; Pyrazofurin; Pyrazomycin; Pyrozofurin; β-Pyrazomycin. Grades: Highly Purified. CAS No. 30868-30-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Herbimycin B Quick inquiry Where to buy Suppliers range | It is produced by the strain of Streptomyces hygroscopicus. It is an ansamycin antibiotic that acts as a Src family kinase inhibitor. It has herbicidal effect on most monocotyledons and dicotyledons, inhibits the activity of tobacco Mosaic virus (TMV), HeLa cells and Ehrlich cells. Synonyms: Geldanamycin, 17-demethoxy-. Grades: ≥95%. CAS No. 76207-83-5. Molecular formula: C28H38N2O8. Mole weight: 530.61. | |
Herbimycin C Quick inquiry Where to buy Suppliers range | Herbimycin C. Uses: Herbimycin C is a minor analogue of the herbimycin complex isolated from Streptomyces hygroscopicus. Herbimycin C possesses potent antitumor activity and converts Rous sarcoma virus-infected rat kidney cells into normal cells. Until now limited access has restricted a full investigation of the properties of herbimycin C. Research on related metabolites, herbimycin A and geldanamycin, has stimulated intensive interest in this class as selective antitumor agents and for prolonging the viability of tissue-cultured cells and organs. Group: Pheromone Ingredients. Grades: 98.0%. CAS No. 91700-92-4. Molecular formula: C29H40N2O9. Mole weight: 560.6. | |
Herbimycin C Quick inquiry Where to buy Suppliers range | It is produced by the strain of Streptomyces hygroscopicus. It is an ansamycin antibiotic that acts as a Src family kinase inhibitor. It has herbicidal effect on most monocotyledons and dicotyledons, inhibits the activity of tobacco Mosaic virus (TMV), HeLa cells and Ehrlich cells. Synonyms: Geldanamycin, 17-demethoxy-15-methoxy-, (15R)-. Grades: >98% by HPLC. CAS No. 91700-92-4. Molecular formula: C29H40N2O9. Mole weight: 560.64. | |
Herbimycin C (Antibiotic TAN 420D) Quick inquiry Where to buy Suppliers range | Herbimycin C is a minor analogue of herbimycin complex isolated from Streptomyces hygroscopicus. Herbimycin C possesses potent antitumor activity and has been shown to convert Rous sarcoma virus-infected rat kidney cells into normal cells. Until now limited access has restricted a full investigation of the properties of herbimycin C. Research on related metabolites, herbimycin A and geldanamycin has stimulated intensive interest in this class as selective antitumor agents and for prolonging the viability of tissue-cultured cells and organs. Group: Biochemicals. Alternative Names: Antibiotic TAN 420D. Grades: Highly Purified. CAS No. 91700-92-4. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
Macbecin I Quick inquiry Where to buy Suppliers range | Macbecin I is an ansamycin antibiotic compound that inhibits Hsp90 by binding to the ATP-binding site (IC50 = 2μM). It exhibits antitumor and cytocidal activities (IC50~ 0.4 μM) by causing degradation of key oncogenic client proteins such as ErbB2 and cRaf1. It exhibits higher affinity and potency than geldanamycin. Grades: >98%. CAS No. 73341-72-7. Molecular formula: C30H42N2O8. Mole weight: 558.67. | |
Ratester Quick inquiry Where to buy Suppliers range | Radester is a hybrid composed of radicicol's resorcinol and geldanamycin's benzoquinone part structures and exhibits good cellular activity against MCF7 breast cancer cells, accompanied by degradation of the Hsp90 clients HER-2 and c-Raf. Synonyms: CHEMBL578372; CHEMBL 578372; CHEMBL-578372; SCHEMBL10186763; SCHEMBL 10186763; SCHEMBL-10186763. Grades: >98%. CAS No. 854485-83-9. Molecular formula: C18H16ClNO8. Mole weight: 409.77. | |
Reblastatin Quick inquiry Where to buy Suppliers range | Reblastatin is an Ansa antibiotic produced by Streptomyces hygroscopicus subsp. hygroscopicus SANK 61995 and is a reduction product of Geldanamycin. It is a cell cycle inhibitor that can inhibit cell proliferation. The IC50 for human mesenchymal lymphoma U-93 is 0.43 μg/mL, and the reference geldanamycin is 0.0011 μg/mL. Molecular formula: C29H44N2O8. Mole weight: 548.67. |