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100mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C15H10O5. CAS No. 446-72-0. Prepack ID 24388232-100mg. Molecular Weight 270.24. See USA prepack pricing.
Genistein
1g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C15H10O5. CAS No. 446-72-0. Prepack ID 24388232-1g. Molecular Weight 270.24. See USA prepack pricing.
Genistein
Cell-permeable, reversible, substrate competitive tyrosine kinase inhibitor (including EGFR phosphorylation), implicated in almost all cell growth and proliferation signal cascades. Inhibitor of mammalian DNA topoisomerase II. Anticancer agent, inducing cell cycle arrest and apoptosis. Antiangiogenic agent, down-regulates the transcription of genes involved in controlling angiogenesis. Binds estrogen receptor beta. Can increase the rate of growth of some ER expressing breast cancers. Potent alpha-glucosidase inhibitor. Anthelmintic. Anti-diabetic. Activates nuclear receptors, oestrogen receptors and peroxisome proliferator-activated receptors (all PPAR isoforms) and it inhibits various enzyme activities. Inhibitor of GLUT4-mediated glucose uptake in 3T3-L1 adipocytes. Stimulator of autophagy vacuolization. Antioxidant. TRAIL sensitizer. Acts as an agonist at the GPR30 receptor. DNA methyltransferase inhibitor. Genistein exhibits synergistic antibacterial effects on MRSA. Group: Biochemicals. Alternative Names: NSC 36586; Baichanin A; Differenol A; 4',5,7-Trihydroxyisoflavone; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. Grades: Highly Purified. CAS No. 446-72-0. Pack Sizes: 10mg, 50mg, 250mg. Molecular Formula: C??H??O?. US Biological Life Sciences.
Worldwide
Genistein
Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM. Genistein is developed to be an antitumor agent. Genistein has antioxidant effect, it can be used in cosmetics material. It is a plant polyphenol that can inhibit tyrosinase, block melanin synthesis, reduce skin pigment intensity, absorb UV, prevent photoaging, reduce sun damage and age spot formation, and whiten and lighten spots. It also has the anti-glycation and antibacterial effect, can effectively improve skin tone and skin texture, prevent the generation of age spots, remove red bloodlines, and improve skin blood microcirculation. Uses: Antitumor agent. Synonyms: 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; Baichanin A; Bonistein; 4',5,7-Trihydroxyisoflavone; GeniVida; Genisteol; NSC 36586; Prunetol; Sophoricol; Differenol A. Grade: >98%. CAS No. 446-72-0. Molecular formula: C15H10O5. Mole weight: 270.24.
Genistein
Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR ) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis , the cell cycle, and angiogenesis and inhibiting metastasis. Uses: Scientific research. Group: Natural products. Alternative Names: NPI 031L. CAS No. 446-72-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-14596.
Genistein
Genistein - Product ID: NST-10-7. Category: Flavonoids. Alternative Names: 4',5,7-Trihydroxyisoflavone. Purity: 98%. Test method: HPLC. CAS No. 446-72-0. Pack Sizes: 25g, 50g, 125g, 250g. Appearance: White to beige coloured Powder. Molecular formula: C15H10O5. Mole weight: 270.24. Storage: +2 +8 °C.
Genistein
Having property of female hormone and antiestrogenic Having oxidation resistance effect Control activity of PTK Control activity of topoisomeraseII. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Sophoricol. Appearance: Off-white powder. CAS No. 446-72-0. Molecular formula: C15H10O5. Mole weight: 270.24. Purity: 0.98. IUPACName: 5,7-Dihydroxy-3-(4-hydroxyphenyl)chromen-4-one. Canonical SMILES: C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O. Density: 1.2319 g/cm³. Product ID: ACM446720. Alfa Chemistry ISO 9001:2015 Certified.
Genistein-[2',3',5',6'-d4] is the labelled analogue of Genistein. Genistein is an inhibitor of angiogenesis. Synonyms: Genistein-2',3',5',6' D4; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-d4. Grade: 95% by HPLC; 95% atom D. CAS No. 187960-08-3. Molecular formula: C15H6D4O5. Mole weight: 274.26.
Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50-2.6uM). Also i. Group: Biochemicals. Alternative Names: 4',5,7-Trihydroxyisoflavone-2,3,5,6-d4. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Genistein-[2',6'-d2]
Genistein-[2',6'-d2] is the labelled analogue of Genistein. Genistein is an inhibitor of angiogenesis. Synonyms: Genistein-2',6' D2; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-d2; Baichanin A-d2; Bonistein-d2; 4',5,7-Trihydroxyisoflavone-d2; GeniVida-d2; Genisteol-d2; NSC 36586-d2; Prunetol-d2; Sophoricol-d2. Grade: 95% by HPLC; 95% atom D. CAS No. 315204-48-9. Molecular formula: C15H8D2O5. Mole weight: 272.25.
Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50-2.6uM). Also i. Group: Biochemicals. Alternative Names: 4',5,7-Trihydroxyisoflavone-2,6-d2. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Genistein (4',5,7-Trihydroxyisoflavone)
Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50-2.6uM). Group: Biochemicals. Alternative Names: 4',5,7-Trihydroxyisoflavone. Grades: Highly Purified. CAS No. 446-72-0. Pack Sizes: 1g, 10g. US Biological Life Sciences.
Worldwide
Genistein 7,4'-di-O- β-D-glucopyranoside
Genistein 7,4'-di-O- β-D-glucopyranoside. Group: Biochemicals. CAS No. 36190-98-4. Pack Sizes: 5mg. US Biological Life Sciences.
A derivative of Genistein. Inhibitor. Isoflavone derivative found in soy-based food products. Group: Biochemicals. Alternative Names: Genistein 7-O-Glucoside; Genistein-7-b-O-Glucopyranoside;7-(b-D-glucopyranosyloxy)-5-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; Genistoside; NSC 5112. Grades: Highly Purified. CAS No. 529-59-9. Pack Sizes: 25mg, 100mg. US Biological Life Sciences.
Worldwide
Genistein-7-sulfate 4- β-D-glucuronide Disodium Salt
Genistein-7-sulfate 4- β-D-glucuronide is a metabolite of Genistein (G350000), a compound that exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences.
A cell-permeable, reversible, substrate competitive inhibitor of protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC?? = 2.6 μM). Group: Fluorescence/luminescence spectroscopy.
2,3,4-Tri-O-acetyl-6-methyl- β-D-glucopyranuronosyl Genistein Glucuronide Methyl Ester Triacetate is the protected metabolite of Genistein (G350000) which exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C41H42O23. US Biological Life Sciences.
4',5-Di-O-acetyl-7-O-tert-butyldimethylsilyl genistein. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5-(Acetyloxy)-3-[4-(acetyloxy)phenyl]-7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4H-1-Benzopyran-4-one. Product Category: Heterocyclic Organic Compound. Appearance: Colourless Solid. CAS No. 470666-99-0. Molecular formula: C25H28O7Si. Mole weight: 468.57. Purity: 0.96. IUPACName: [4-[5-acetyloxy-7-[tert-butyl(dimethyl)silyl]oxy-4-oxochromen-3-yl]phenyl] acetate. Canonical SMILES: CC(=O)OC1=CC=C(C=C1)C2=COC3=CC(=CC(=C3C2=O)OC(=O)C)O[Si](C)(C)C(C)(C)C. Product ID: ACM470666990. Alfa Chemistry ISO 9001:2015 Certified.
Protected Genistein. Group: Biochemicals. Alternative Names: 5- (Acetyloxy) -3-[4- (acetyloxy) phenyl]-7-[[ (1, 1-dimethylethyl) dimethylsilyl]oxy]-4H-1-Benzopyran-4-one. Grades: Highly Purified. CAS No. 470666-99-0. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
4',5-Di-O-acetyl genistein
4',5-Di-O-acetyl genistein. Group: Biochemicals. Alternative Names: 5-(acetyloxy)-3-[4-(acetyloxy)phenyl]-7-hydroxy-4H-1-benzopyran-4-one. Grades: Highly Purified. CAS No. 656229-81-1. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C19H14O7. US Biological Life Sciences.
Worldwide
4,5-Di-O-acetyl Genistein
Protected Genistein. Group: Biochemicals. Alternative Names: 5-(acetyloxy)-3-[4-(acetyloxy)phenyl]-7-hydroxy-. Grades: Highly Purified. CAS No. 656229-81-1. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
4'-O-tert-Butyldimethylsilyl genistein
4'-O-tert-Butyldimethylsilyl genistein. Group: Biochemicals. Alternative Names: 3- [4- [ [ (1, 1-Dimethylethyl) dimethylsilyl] oxy] phenyl] -5, 7-dihydroxy-4H-1-benzopyran-4-one. Grades: Highly Purified. CAS No. 470666-97-8. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C21H24O5Si. US Biological Life Sciences.
Worldwide
4-O-tert-Butyldimethylsilyl Genistein
Protected Genistein. Group: Biochemicals. Alternative Names: 3- [4- [ [ (1, 1-Dimethylethyl) dimethylsilyl] oxy] phenyl] -5, 7-dihydroxy-4H-1-benzopyran-4-one. Grades: Highly Purified. CAS No. 470666-97-8. Pack Sizes: 25mg. US Biological Life Sciences.
Requires cytochrome P-450. The reaction involves the migration of the 2-phenyl group of the flavanone to the 3-position of the isoflavanone. The 2-hydroxyl group is derived from the oxygen molecule. EC 4.2.1.105, 2-hydroxyisoflavanone dehydratase, acts on the products with loss of water and formation of genistein and daidzein, respectively. Group: Enzymes. Synonyms: CYP93C; IFS; isoflavonoid synthase. Enzyme Commission Number: EC 1.14.13.136. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0735; 2-hydroxyisoflavanone synthase; EC 1.14.13.136; CYP93C; IFS; isoflavonoid synthase. Cat No: EXWM-0735.
4''-methyloxy-Genistin
4''-methyloxy-Genistin. Group: Biochemicals. Alternative Names: Genistein 7-O-beta-D-glucoside-4''-O-methylate. Grades: Plant Grade. CAS No. 950910-16-4. Pack Sizes: 10mg. Molecular Formula: C22H22O10, Molecular Weight: 446.408. US Biological Life Sciences.
Negative control for genistein. Group: Biochemicals. Grades: Highly Purified. CAS No. 486-66-8. Pack Sizes: 1g. US Biological Life Sciences.
Worldwide
Daidzein - CAS 486-66-8
Inactive analog of Genistein. Group: Fluorescence/luminescence spectroscopy.
Daidzein Diglucuronide
Daidzein Diglucuronide is a metabolite of Daidzein (D103500) which is an inactive analog of Genistein (G350000). Genistein blocks the G1 phase of the cell cycle in Swiss 3T3 cells by inhibiting casein kinase II activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 335591-27-0. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C27H26O16. US Biological Life Sciences.
Worldwide
flavonoid 4'-O-methyltransferase
The enzyme catalyses the 4'-methylation of naringenin. In vitro it catalyses the 4'-methylation of apigenin, quercetin, daidzein and genistein. Group: Enzymes. Synonyms: SOMT-2; 4'-hydroxyisoflavone methyltransferase. Enzyme Commission Number: EC 2.1.1.231. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1834; flavonoid 4'-O-methyltransferase; EC 2.1.1.231; SOMT-2; 4'-hydroxyisoflavone methyltransferase. Cat No: EXWM-1834.
Genistin
Genistin (Genistine), an isoflavone belonging to the phytoestrogen family, is a potent anti-adipogenic and anti-lipogenic agent. Genistin attenuates cellular growth and promotes apoptotic cell death breast cancer cells through modulation of ERalpha signaling pathway [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Genistine; Genistoside; Genistein 7-O-β-D-glucopyranoside. CAS No. 529-59-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-N0595.
Genistin
Genistin is the major isoflavonoid found in soybeans and soy products. Studies in the 1970s suggested that 99% of the isoflavonoid compounds in soy products are present as their glucosides. Genistin acts as a selective estrogen receptor modulator (SERM) and exhibits antioxidant activity and anticarcinogenic property. Uses: Antioxidant, anticarcinogenic. Synonyms: 7-(b-D-Glucopyranosyloxy)-5-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 4,5,7-Trihydroxyisoflavone 7-b-D-glucoside; Genistein-7-O-beta-D-glucopyranoside. Grade: >98%. CAS No. 529-59-9. Molecular formula: C21H20O10. Mole weight: 432.38.
A heme-thiolate protein (P-450). Acts on daidzein, formononetin and genistein. EC 1.14.13.53, 4'-methoxyisoflavone 2'-hydroxylase, has the same reaction but is more specific as it requires a 4'-methoxyisoflavone. Group: Enzymes. Synonyms: isoflavone 2'-monooxygenase; CYP81E1; CYP Ge-3. Enzyme Commission Number: EC 1.14.13.89. CAS No. 110183-49-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0897; isoflavone 2'-hydroxylase; EC 1.14.13.89; 110183-49-8; isoflavone 2'-monooxygenase; CYP81E1; CYP Ge-3. Cat No: EXWM-0897.
isoflavone 4'-O-methyltransferase
Requires Mg2+ for activity. The enzyme catalyses the methylation of daidzein and genistein. It does not methylate naringenin, apigenin, luteolin or kaempferol. Group: Enzymes. Synonyms: 4'-hydroxyisoflavone methyltransferase; isoflavone methyltransferase; isoflavone O-methyltransferase. Enzyme Commission Number: EC 2.1.1.46. CAS No. 55071-80-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1950; isoflavone 4'-O-methyltransferase; EC 2.1.1.46; 55071-80-2; 4'-hydroxyisoflavone methyltransferase; isoflavone methyltransferase; isoflavone O-methyltransferase. Cat No: EXWM-1950.
isoflavone 7-O-glucosyltransferase
The 4'-methoxy isoflavones biochanin A and formononetin and, more slowly, the 4'-hydroxyisoflavones genistein and daidzein, can act as acceptors. The enzyme does not act on isoflavanones, flavones, flavanones, flavanols or coumarins. Group: Enzymes. Synonyms: uridine diphosphoglucose-isoflavone 7-O-glucosyltransferase; UDPglucose-favonoid 7-O-glucosyltransferase; UDPglucose:isoflavone 7-O-glucosyltransferase. Enzyme Commission Number: EC 2.4.1.170. CAS No. 97089-62-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2395; isoflavone 7-O-glucosyltransferase; EC 2.4.1.170; 97089-62-8; uridine diphosphoglucose-isoflavone 7-O-glucosyltransferase; UDPglucose-favonoid 7-O-glucosyltransferase; UDPglucose:isoflavone 7-O-glucosyltransferase. Cat No: EXWM-2395.
isoflavone 7-O-methyltransferase
The enzyme from alfalfa can methylate daidzein, genistein and 6,7,4'-trihydroxyisoflavone but not flavones or flavanones. Group: Enzymes. Enzyme Commission Number: EC 2.1.1.150. CAS No. 136111-54-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1746; isoflavone 7-O-methyltransferase; EC 2.1.1.150; 136111-54-1. Cat No: EXWM-1746.
kaempferol 4'-O-methyltransferase
The enzyme acts on the hydroxy group in the 4'-position of some flavones, flavanones and isoflavones. Kaempferol, apigenin and kaempferol triglucoside are substrates, as is genistein, which reacts more slowly. Compounds with an hydroxy group in the 3' and 4' positions, such as quercetin and eriodictyol, do not act as substrates. Similar to EC 2.1.1.75, apigenin 4'-O-methyltransferase and EC 2.1.1.83, 3,7-dimethylquercetin 4'-O-methyltransferase. Group: Enzymes. Synonyms: S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase; F 4'-OMT. Enzyme Commission Number: EC 2.1.1.155. CAS No. 80747-20-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1751; kaempferol 4'-O-methyltransferase; EC 2.1.1.155; 80747-20-2; S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase; F 4'-OMT. Cat No: EXWM-1751.
Kudzu Root Extract (Standard)
Kudzu root has been known for centuries in traditional Chinese medicine as ge-gen. The first written mention of the plant as a medicine is in the ancient herbal text of Shen Nong (about A.D.100). In traditional Chinese medicine, kudzu root is used in prescriptions for the treatment of thirst, headache, and stiff neck with pain due to high blood pressure. It is also recommended for allergies, migraine headaches, inadequate measles eruptions in children, and diarrhea It is also used in modern Chinese medicine as a treatment for angina pectoris. Applications: Kudzu root extract is used as remedy for diaphoretic,antispasmodic,muscle relaxant,antipyretic.kudzu root extract is also used for fevers caused by heat in colds and influenza and for stiff neck and shoulders. Group: Others. CAS No. Puerarin: 3681-99-0Genistein: 446-72-0Daidzin: 552-66-9Daidzein: 486-66-8. Purity: 40.0% Isoflavones UV/HPLC. Mole weight: Puerarin: 416.37Genistein: 270.23Daidzin: 416.38Daidzein: 254.23. Kudzu Root Extract (Standard); Puerarin: 3681-99-0Genistein: 446-72-0Daidzin: 552-66-9Daidzein: 486-66-8; Puerarin: C21H20O9Genistein: C15H10O5Daidzin: C21H20O9Daidzein: C10H15O4. Cat No: EXTW-008.
Sophoricoside
Sophoricoside. Group: Biochemicals. Alternative Names: Genistein 4?-glucoside. Grades: Plant Grade. CAS No. 152-95-4. Pack Sizes: 20mg. Molecular Formula: C21H20O10, Molecular Weight: 432.377999999999. US Biological Life Sciences.
Worldwide
Sophoricoside
Sophoricoside - Product ID: NST-10-40. Category: Flavonoids. Alternative Names: Genistein-4'-O-glucoside. Purity: 98%. Test method: HPLC. CAS No. 152-95-4. Pack Sizes: 10g, 20g, 50g, 100g. Appearance: White to beige coloured Powder. Molecular formula: C21H20O10. Mole weight: 432.38. Storage: +2 +8 °C.
Tectorigenin
Tectorigenin induced differentiation of human promyelocytic leukemia HL-60 cells to granulocytes and monocytes/macrophages, and caused apoptotic changes of DNA in the cells, as did genistein. Tectorigenin also inhibited autophosphorylation of epidermal growth factor (EGF) receptor by EGF and decreased the expression of Bcl-2 protein, with less activity than genistein. From these results, tectorigenin may be a possible therapeutic agent for leukemia. Uses: Antioxidant. Synonyms: 5,7-Dihydroxy-3-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one; 6-Methoxy-5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-6-methoxy-; Isoflavone, 4',5,7-trihydroxy-6-methoxy-; 5,7,4'-Trihydroxy-6-methoxyisoflavone; K 251T; Tectrigenin. Grade: >98%. CAS No. 548-77-6. Molecular formula: C16H12O6. Mole weight: 300.26.
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