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| Product | Description | |
|---|---|---|
| Geranylgeranylacetone | Geranylgeranylacetone is commonly utilized to protect the gastric mucosa in peptic ulcer disease can induce expression of HSP70, HSPB8, and HSPB1. Uses: An anti-ulcerative. Synonyms: Teprenone; 6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraen-2-one. Grades: ≥95%. CAS No. 6809-52-5. Molecular formula: C23H38O. Mole weight: 330.55. |  |
| geranylgeranyl-bacteriochlorophyllide a reductase | The enzyme catalyses the successive reduction of the geranylgeraniol esterifying group to phytol, reducing three out of four double bonds, and transforming geranylgeranyl bacteriochlorophyllide a via dihydrogeranylgeranyl bacteriochlorophyllide a and tetrahydrogeranylgeranyl bacteriochlorophyllide a to bacteriochlorophyll a. The enzyme can also accept the pheophytin derivative geranylgeranyl bacteriopheophytin, converting it to bacteriopheophytin a. Group: Enzymes. Synonyms: geranylgeranyl-bacteriopheophytin reductase; bchP (gene name). Enzyme Commission Number: EC 1.3.1.111. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1284; geranylgeranyl-bacteriochlorophyllide a reductase; EC 1.3.1.111; geranylgeranyl-bacteriopheophytin reductase; bchP (gene name). Cat No: EXWM-1284. |  |
| geranylgeranyl diphosphate diphosphatase | Involved in the biosynthesis of plaunotol. There are two isoenzymes with different ion requirements. Neither require Mg2+ but in addition PII is inhibited by Zn2+, Mn2+ and Co2+. It is not known which isoenzyme is involved in plaunotol biosynthesis. Group: Enzymes. Synonyms: geranylgeranyl diphosphate phosphatase. Enzyme Commission Number: EC 3.1.7.5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3765; geranylgeranyl diphosphate diphosphatase; EC 3.1.7.5; geranylgeranyl diphosphate phosphatase. Cat No: EXWM-3765. | |
| geranylgeranyl diphosphate reductase | This enzyme also acts on geranylgeranyl-chlorophyll a. The reaction occurs in three steps. Which order the three double bonds are reduced is not known. Group: Enzymes. Synonyms: geranylgeranyl reductase; CHL P. Enzyme Commission Number: EC 1.3.1.83. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1352; geranylgeranyl diphosphate reductase; EC 1.3.1.83; geranylgeranyl reductase; CHL P. Cat No: EXWM-1352. | |
| geranylgeranyl diphosphate synthase | Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; it will not use larger prenyl diphosphates as efficient donors. Group: Enzymes. Synonyms: geranylgeranyl-diphosphate synthase; geranylgeranyl pyrophosphate synthetase; geranylgeranyl-PP synthetase; farnesyltransferase; geranylgeranyl pyrophosphate synthase; farnesyltranstransferase (obsolete). Enzyme Commission Number: EC 2.5.1.29. CAS No. 9032-58-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2766; geranylgeranyl diphosphate synthase; EC 2.5.1.29; 9032-58-0; geranylgeranyl-diphosphate synthase; geranylgeranyl pyrophosphate synthetase; geranylgeranyl-PP synthetase; farnesyltransferase; geranylgeranyl pyrophosphate synthase; farnesyltranstransferase (obsolete). Cat No: EXWM-2766. | |
| geranylgeranylglycerol-phosphate geranylgeranyltransferase | This enzyme is an integral-membrane protein that carries out the second prenyltransfer reaction involved in the formation of polar membrane lipids in Archaea. Requires a divalent metal cation, such as Mg2+ or Mn2+, for activity. 4-Hydroxybenzoate, 1,4-dihydroxy 2-naphthoate, homogentisate and α-glycerophosphate cannot act as prenyl-acceptor substrates. The other enzymes involved in the biosynthesis of polar lipids in Archaea are EC 1.1.1.261 (sn-glycerol-1-phosphate dehydrogenase), EC 2.5.1.41 (phosphoglycerol geranylgeranyltransferase), which, together with this enzyme, alkylates the hydroxy groups of glycerol 1-phosphate to yield unsaturated archaetidic a...ranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase. Enzyme Commission Number: EC 2.5.1.42. CAS No. 124650-68-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2778; geranylgeranylglycerol-phosphate geranylgeranyltransferase; EC 2.5.1.42; 124650-68-6; geranylgeranyloxyglycerol phosphate geranylgeranyltransferase; geranylgeranyltransferase II; (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase; DGGGP synthase; DGGGPS; geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase. Cat No: EXWM-2778. | |
| Geranylgeranyl Pyrophosphate | Geranylgeranyl Pyrophosphate is a non-peptide antigens recognized by human γδ T cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 6699-20-3. Pack Sizes: 1mg, 10mg. Molecular Formula: C20H36O7P2, Molecular Weight: 450.44. US Biological Life Sciences. |  Worldwide |
| Geranylgeranyl pyrophosphate ammonium salt | solution, ?95% (TLC), ~1 mg/mL in methanol: NH4OH (7:3). Group: Fluorescence/luminescence spectroscopy. |  |
| Geranylgeranyl pyrophosphate triammonium | Geranylgeranyl pyrophosphate triammonium is a metabolite involved in protein geranylgeranylation. Geranylgeranyl pyrophosphate triammonium is the common precursor of diterpenoids, for example, Paclitaxel. Geranylgeranyl pyrophosphate triammonium can be used for cancer research [1]. Uses: Scientific research. Group: Natural products. CAS No. 313263-08-0. Pack Sizes: 250 μg (1.99 mM * 250 μL in 10mM NH4OH); 500 μg (1.99 mM * 500 μL in 10mM NH4OH); 1 mg (1.99 mM * 1 mL in 10mM NH4OH). Product ID: HY-126370A. |  |
| Geranylgeranyl pyrophosphate triammonium salt | Geranylgeranyl pyrophosphate triammonium salt. Group: Biochemicals. Alternative Names: Diphosphoric acid P-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl] ester ammonium salt; Diphosphoric acid mono[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl] ester triammonium salt. Grades: Highly Purified. CAS No. 313263-08-0. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C20H45N3O7P2. US Biological Life Sciences. | Worldwide |
| Geranylgeranyltransferase from rat, Recombinant | Geranylgeranyltransferase type 1 or simply geranylgeranyltransferase is one of the three enzymes in the prenyltransferase group. In specific terms, Geranylgeranyltransferase (GGTase 1) adds a 20-carbon isoprenoid called a geranylgeranyl group to proteins bearing a CaaX motif:a four-amino acid sequence at the carboxyl terminal of a protein. Geranylgeranyltransferase inhibitors are being investigated as anti-cancer agents. >80% (sds-page), recombinant, expressed in baculovirus infected insect cells, > 200 units/mg protein. Group: Enzymes. Synonyms: geranylgeranyltransferase type I; GGTase-I; GGTase; 160141-09-3; Geranylgeranyltransferase. CAS No. 160141-09-3. Purity: >80% (SDS-PAGE). GGTase. Mole weight: mol wt 43 kDa (β subunit); mol wt 48 kDa (α subunit). Activity: > 200 units/mg protein. Stability: -70°C. Form: Solution. Source: baculovirus infected insect cells. Species: Rat. geranylgeranyltransferase type I; GGTase-I; GGTase; 160141-09-3; Geranylgeranyltransferase. Cat No: NATE-0285. | |
| Geranylgeranyltransferase I, GST-Fusion, His Tag, Rat, Recombinant, E. coli | Geranylgeranyltransferase I, GST-Fusion, Rat, Recombinant, E. coli, contains a 74 kDa ?- & 43 kDa ?-subunit. The ?-subunit is expressed as a GST-fusion construct with an N-terminal His Tag. Group: Fluorescence/luminescence spectroscopy. | |
| Geranylgeranyltri phenylphosphonium Bromide | Geranylgeranyltri phenylphosphonium Bromide. Group: Biochemicals. Alternative Names: Triphenyl [ (2E, 6E, 10E) -3, 7, 11, 15-tetramethyl-2, 6, 10, 14-hexadecatetraenyl] phosphonium Bromide. Grades: Highly Purified. CAS No. 57784-37-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H] | A flavoprotein (FAD). The enzyme from the archaeon Thermoplasma acidophilum is involved in the biosynthesis of membrane lipids. In vivo the reaction occurs in the reverse direction with the formation of 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate. cf. EC 1.3.7.11, 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase. Group: Enzymes. Synonyms: digeranylgeranylglycerophospholipid reductase; Ta0516m (gene name); DGGGPL reductase; 2,3-digeranylgeranylglycerophospholipid reductase. Enzyme Commission Number: EC 1.3.1.101. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1273; 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H]; EC 1.3.1.101; digeranylgeranylglycerophospholipid reductase; Ta0516m (gene name); DGGGPL reductase; 2,3-digeranylgeranylglycerophospholipid reductase. Cat No: EXWM-1273. | |
| 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase | A flavoprotein (FAD). The enzyme is involved in the biosynthesis of archaeal membrane lipids. It catalyses the reduction of all 8 double bonds in 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipids and all 4 double bonds in 3-O-geranylgeranyl-sn-glycerol phospholipids with comparable activity. Unlike EC 1.3.1.101, 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H], this enzyme shows no activity with NADPH, and requires a dedicated ferredoxin. Group: Enzymes. Synonyms: AF0464 (gene name); 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase (donor). Enzyme Commission Number: EC 1.3.7.11. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1392; 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase; EC 1.3.7.11; AF0464 (gene name); 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase (donor). Cat No: EXWM-1392. | |
| all-trans-nonaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific] | Geranylgeranyl diphosphate is preferred over farnesyl diphosphate as allylic substrate. The plant Arabidopsis thaliana has two different enzymes that catalyse this reaction. SPS1 contributes to the biosynthesis of the ubiquinone side-chain while SPS2 supplies the precursor of the plastoquinone side-chains. Group: Enzymes. Synonyms: nonaprenyl diphosphate synthase (ambiguous); solanesyl diphosphate synthase (ambiguous); At-SPS2; At-SPS1; SPS1; SPS2. Enzyme Commission Number: EC 2.5.1.85. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2823; all-trans-nonaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]; EC 2.5.1.85; nonaprenyl diphosphate synthase (ambiguous); solanesyl diphosphate synthase (ambiguous); At-SPS2; At-SPS1; SPS1; SPS2. Cat No: EXWM-2823. | |
| CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase | This enzyme catalyses one of the steps in the biosynthesis of polar lipids in archaea, which are characterized by having an sn-glycerol 1-phosphate backbone rather than an sn-glycerol 3-phosphate backbone as is found in bacteria and eukaryotes. The enzyme requires Mg2+ and K+ for maximal activity. Group: Enzymes. Synonyms: carS (gene name); CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase; CTP:2,3-GG-GP ether cytidylyltransferase; CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase; CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol synthase; CTP:2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phosphate cytidylyltransferase; CDP-unsaturated archaeol synthase; . Enzyme Commission Number: EC 2.7.7.67. CAS No. 329791-09-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3278; CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase; EC 2.7.7.67; 329791-09-5; carS (gene name); CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase; CTP:2,3-GG-GP ether cytidylyltransferase; CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase; CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol synthase; CTP:2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phosphate cytidylyltransferase; CDP-unsaturated archaeol synthase; CDP-archaeol synthase (incorrect). Cat No: EXWM-3278. | |
| hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific] | The enzyme prefers geranylgeranyl diphosphate to farnesyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and dimethylallyl diphosphate. Requires Mg2+. Group: Enzymes. Synonyms: HexPS(ambiguous); (all-E) hexaprenyl diphosphate synthase; (all-trans) hexaprenyl diphosphate synthase; hexaprenyl pyrophosphate synthase (ambiguous); HexPPs (ambiguous); hexaprenyl diphosphate synthase (ambiguous). Enzyme Commission Number: EC 2.5.1.82. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2820; hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]; EC 2.5.1.82; HexPS(ambiguous); (all-E) hexaprenyl diphosphate synthase; (all-trans) hexaprenyl diphosphate synthase; hexaprenyl pyrophosphate synthase (ambiguous); HexPPs (ambiguous); hexaprenyl diphosphate synthase (ambiguous). Cat No: EXWM-2820. | |
| homogentisate geranylgeranyltransferase | Requires Mg2+ for activity. Involved in the biosynthesis of the vitamin E, tocotrienols. While the enzyme from the bacterium Synechocystis PCC 6803 has higher activity with phytyl diphosphate (EC 2.5.1.115, homogentisate phytyltransferase), the enzymes from barley, rice and wheat have only a low activity with that substrate. Group: Enzymes. Synonyms: HGGT; slr1736 (gene name). Enzyme Commission Number: EC 2.5.1.116. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2732; homogentisate geranylgeranyltransferase; EC 2.5.1.116; HGGT; slr1736 (gene name). Cat No: EXWM-2732. | |
| N-acetyl-S-geranylgeranyl-L-cysteine | N-acetyl-S-geranylgeranyl-L-Cysteine is an inhibitor of the isoprenylated protein methyltransferase. Synonyms: AGGC; (2R)-2-acetamido-3-[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]sulfanylpropanoic acid. Grades: ≥95%. CAS No. 139332-94-8. Molecular formula: C25H41NO3S. Mole weight: 435.7. | |
| phosphoglycerol geranylgeranyltransferase | This cytosolic enzyme catalyses the first pathway-specific step in the biosynthesis of the core membrane diether lipids in archaebacteria. Requires Mg2+ for maximal activity. It catalyses the alkylation of the primary hydroxy group in sn-glycerol 1-phosphate by geranylgeranyl diphosphate (GGPP) in a prenyltransfer reaction where a hydroxy group is the nucleophile in the acceptor substrate. The other enzymes involved in the biosynthesis of polar lipids in Archaea are EC 1.1.1.261 (sn-glycerol-1-phosphate dehydrogenase), EC 2.5.1.42 (geranylgeranylglycerol-phosphate geranylgeranyltransferase) and EC 2.7.7.67 (CDP-archaeol synthase), which lead to the formation of CDP-unsat... Number: EC 2.5.1.41. CAS No. 124650-69-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2777; phosphoglycerol geranylgeranyltransferase; EC 2.5.1.41; 124650-69-7; glycerol phosphate geranylgeranyltransferase; geranylgeranyl-transferase (ambiguous); prenyltransferase (ambiguous); (S)-3-O-geranylgeranylglyceryl phosphate synthase; (S)-geranylgeranylglyceryl phosphate synthase; GGGP synthase; (S)-GGGP synthase; GGGPS; geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase; geranylgeranyl diphosphate:sn-glycerol-1-phosphate geranylgeranyltransferase. Cat No: EXWM-2777. | |
| protein geranylgeranyltransferase type I | This enzyme, along with protein farnesyltransferase (EC 2.5.1.58) and protein geranylgeranyltransferase type II (EC 2.5.1.60), constitutes the protein prenyltransferase family of enzymes. Catalyses the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. These protein acceptors have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine; serine, methionine, alanine or glutamine makes the protein a substrate for EC 2.5.1.58. The enzymes are relaxed in specificity for A1, but cannot act if A2 is aromatic. Known targets of this enzyme include most γ-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families. A zinc metalloenzyme. The Zn2+ is required for peptide, but not for isoprenoid, substrate binding. Group: Enzymes. Synonyms: GGTase-I; GGTaseI. Enzyme Commission Number: EC 2.5.1.59. CAS No. 135371-29-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2796; protein geranylgeranyltransferase type I; EC 2.5.1.59; 135371-29-8; GGTase-I; GGTaseI. Cat No: EXWM-2796. | |
| protein geranylgeranyltransferase type II | This enzyme, along with protein farnesyltransferase (EC 2.5.1.58) and protein geranylgeranyltransferase type I (EC 2.5.1.59), constitutes the protein prenyltransferase family of enzymes. Attaches geranylgeranyl groups to two C-terminal cysteines in Ras-related GTPases of a single family, the Rab family (Ypt/Sec4 in lower eukaryotes) that terminate in XXCC, XCXC and CCXX motifs. Reaction is entirely dependent on the Rab substrate being bound to Rab escort protein (REP). Post-translational modification with the geranylgeranyl moiety is essential for Rab GTPases to be able to control the processes of membrane docking and fusion. Group: Enzymes. Synonyms: GGTaseII; Rab geranylgeranyltransferase; RabGGTase; geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase. Enzyme Commission Number: EC 2.5.1.60. CAS No. 135371-29-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2798; protein geranylgeranyltransferase type II; EC 2.5.1.60; 135371-29-8; GGTaseII; Rab geranylgeranyltransferase; RabGGTase; geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase. Cat No: EXWM-2798. | |
| tritrans,polycis-undecaprenyl-diphosphate synthase [geranylgeranyl-diphosphate specific] | This enzyme is involved in the biosynthesis of the glycosyl carrier lipid in some archaebacteria. Unlike EC 2.5.1.31, its counterpart in most bacteria, it prefers geranylgeranyl diphosphate to farnesyl diphosphate as the allylic substrate, resulting in production of a tritrans,polycis variant of undecaprenyl diphosphate. Group: Enzymes. Enzyme Commission Number: EC 2.5.1.89. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2827; tritrans,polycis-undecaprenyl-diphosphate synthase [geranylgeranyl-diphosphate specific]; EC 2.5.1.89. Cat No: EXWM-2827. | |
| 15-cis-phytoene synthase | Requires Mn2+ for activity. The enzyme produces 15-cis-phytoene. cf. EC 2.5.1.99, 15-trans-phytoene synthase. Group: Enzymes. Synonyms: prephytoene-diphosphate synthase (ambiguous); phytoene synthetase (ambiguous); PSase (ambiguous); geranylgeranyl-diphosphate geranylgeranyltransferase (ambiguous). Enzyme Commission Number: EC 2.5.1.32. CAS No. 50936-61-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2770; 15-cis-phytoene synthase; EC 2.5.1.32; 50936-61-3; prephytoene-diphosphate synthase (ambiguous); phytoene synthetase (ambiguous); PSase (ambiguous); geranylgeranyl-diphosphate geranylgeranyltransferase (ambiguous). Cat No: EXWM-2770. | |
| 2-carboxy-1,4-naphthoquinone phytyltransferase | This enzyme, found in plants and cyanobacteria, catalyses a step in the synthesis of phylloquinone (vitamin K1), an electron carrier associated with photosystem I. The enzyme catalyses the transfer of the phytyl chain synthesized by EC 1.3.1.83, geranylgeranyl diphosphate reductase, to 2-carboxy-1,4-naphthoquinone. Group: Enzymes. Synonyms: menA (gene name); ABC4 (gene name); 1,4-dioxo-2-naphthoate phytyltransferase; 1,4-diketo-2-naphthoate phytyltransferase. Enzyme Commission Number: EC 2.5.1.130. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2746; 2-carboxy-1,4-naphthoquinone phytyltransferase; EC 2.5.1.130; menA (gene name); ABC4 (gene name); 1,4-dioxo-2-naphthoate phytyltransferase; 1,4-diketo-2-naphthoate phytyltransferase. Cat No: EXWM-2746. | |
| 4- (tert-Butyldi methyl silyloxy methyl ) bromo Benzene | Used in the preparation of aromatic bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase. Group: Biochemicals. Alternative Names: 4-Bromobenzyl dimethyl-tert-butylsilyl Ether; (4-Bromobenzyl)oxy](tert-butyl)dimethylsilane; 1-Bromo-4- [ [ [ (1, 1-dimethylethyl) dimethylsilyl] oxy] methyl] -benzene. Grades: Highly Purified. CAS No. 87736-74-1. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Acetochlor | Acetochlor is a chloroacetanilides related herbicide that inhibits elongase and geranylgeranyl pyrophosphate (GGPP) cyclization enzymes (1,2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Group: Biochemicals. Grades: Highly Purified. CAS No. 34256-82-1. Pack Sizes: 100mg, 250mg. Molecular Formula: C14H20ClNO2. US Biological Life Sciences. | Worldwide |
| Acetochlor-13C4 | Isotope labelled Acetochlor (A162500), which is a chloroacetanilides related herbicide that inhibits elongase and geranylgeranyl pyrophosphate (GGPP) cyclization enzymes (1,2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C1013C4H20ClNO2, Molecular Weight: 273.74. US Biological Life Sciences. | Worldwide |
| Acetochlor OA | Acetochlor OA is a metabolite of Acetochlor (A162500), which is a chloroacetanilide related herbicide that inhibits elongase and geranylgeranyl pyrophosphate (GGPP) cyclization enzymes. Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Group: Biochemicals. Grades: Highly Purified. CAS No. 194992-44-4. Pack Sizes: 10mg, 25mg. Molecular Formula: C14H19NO4, Molecular Weight: 265.31. US Biological Life Sciences. | Worldwide |
| all-trans-nonaprenyl-diphosphate synthase [geranyl-diphosphate specific] | (2E,6E)-Farnesyl diphosphate and geranylgeranyl diphosphate are less effective as substrates than geranyl diphosphate. The enzyme is involved in the synthesis of the side chain of menaquinone-9. In Oryza sativa the enzyme SPS2 is involved in providing solanesyl diphosphate for plastoquinone-9 formation. Group: Enzymes. Synonyms: nonaprenyl diphosphate synthase (ambiguous); solanesyl diphosphate synthase (ambiguous); SolPP synthase (ambiguous); SPP-synthase (ambiguous); SPP synthase (ambiguous); solanesyl-diphosphate synthase (ambiguous); OsSPS2. Enzyme Commission Number: EC 2.5.1.84. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2822; all-trans-nonaprenyl-diphosphate synthase [geranyl-diphosphate specific]; EC 2.5.1.84; nonaprenyl diphosphate synthase (ambiguous); solanesyl diphosphate synthase (ambiguous); SolPP synthase (ambiguous); SPP-synthase (ambiguous); SPP synthase (ambiguous); solanesyl-diphosphate synthase (ambiguous); OsSPS2. Cat No: EXWM-2822. | |
| all-trans-phytoene synthase | Requires Mn2+ for activity. The enzyme from the bacterium Pantoea agglomerans (previously known as Erwinia herbicola) produces the all-trans isomer of phytoene. cf. EC 2.5.1.32, 15-cis-phytoene synthase. Group: Enzymes. Synonyms: prephytoene-diphosphate synthase (ambiguous); phytoene synthetase (ambiguous); PSase (ambiguous); geranylgeranyl-diphosphate geranylgeranyltransferase (ambiguous); 15-trans-phytoene synthase. Enzyme Commission Number: EC 2.5.1.99. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2838; all-trans-phytoene synthase; EC 2.5.1.99; prephytoene-diphosphate synthase (ambiguous); phytoene synthetase (ambiguous); PSase (ambiguous); geranylgeranyl-diphosphate geranylgeranyltransferase (ambiguous); 15-trans-phytoene synthase. Cat No: EXWM-2838. | |
| All trans-Teprenone | All-trans form of Teprenone, which could be used as an anti-ulcerative agent and has been found to induce the expression of HSP70, HSPB8, and HSPB1. Synonyms: 6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraen-2-one; (5E,9E,13E)-Geranylgeranylacetone. Grades: > 95%. CAS No. 3796-63-2. Molecular formula: C23H38O. Mole weight: 330.56. | |
| AZD-3409 | AZD-3409 is a potent prenyl transferase inhibitor. AZD-3409 showed higher potency than lonafarnib. AZD3409 inhibits farnesylation to a higher extent than geranylgeranylation. AZD3409 might be active in gefitinib-resistant breast carcinoma. Synonyms: AZD-3409; AZD 3409; AZD3409. Grades: 98%. CAS No. 345915-10-8. Molecular formula: C34H41FN4O4S2. Mole weight: 652.844. | |
| bacteriochlorophyll a synthase | The enzyme catalyses the addition of a geranylgeranyl hydrophobic chain to bacteriochlorophyllide a via an ester bond with the 17-propionate residue. The side chain is later modified to a phytyl chain, resulting in bacteriochlorophyll a. Group: Enzymes. Synonyms: bchG (gene name). Enzyme Commission Number: EC 2.5.1.133. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2749; bacteriochlorophyll a synthase; EC 2.5.1.133; bchG (gene name). Cat No: EXWM-2749. | |
| Beta-Carotene ( β, β-Carotene, β-Carotene, Provitamin A) | Antioxidant; antineoplastic; inudces cell differentiation. β-carotene (beta-carotine) is a strongly colored red-orange pigment abundant in plants and fruits. It is an organic compound and chemically is classified as a hydrocarbon and specifically as a terpenoid (isoprenoid), reflecting its derivation from isoprene units. β-Carotene is biosynthesized from geranylgeranyl pyrophosphate. It is a member of the carotenes, which are tetraterpenes, synthesized biochemically from eight isoprene units and thus having 40 carbons. Among this general class of carotenes, β-carotene is distinguished by having beta-rings at both ends of the molecule. Absorption of β-carotene is enhanced if eaten with fats, as carotenes are fat soluble. β-Carotene has been used to treat various disorders such as erythropoietic protoporphyria. It has also been used to reduce the risk of breast cancer in women before menopause, and the risk of age-related macular degeneration (AMD). Group: Biochemicals. Alternative Names: β-Carotene; Betacarotene; β, β-Carotene; Provatene; Lucarotin; KPMK; Food Orange 5; Provitamin A; NSC 62794; (all-E)-1,1'-(3,7,12,16-t. Grades: Highly Purified. CAS No. 7235-40-7. Pack Sizes: 5g, 10g, 25g. Molecular Formula: C40H56, Molecular Weight: 536.87. US Biological Life Sciences. | Worldwide |
| BPH715 | BPH715 is a new generation of lipophilic bisphosphonates. It is potent in cell culture and effectively inhibited tumor cell growth and invasiveness. It is used as anticancer agents that block protein prenylation also have potent activity against Plasmodium liver stages. It has activity against a Plasmodium geranylgeranyl diphosphate synthase (GGPPS), as well as low nM activity against human farnesyl and geranylgeranyl diphosphate synthases. It is used to treat bone resorption diseases and has activity against a broad range of protists, including blood-stage Plasmodium spp. Uses: Bph715 is used as anticancer agents that block protein prenylation also have potent activity against plasmodium liver stages. it is also used to treat bone resorption diseases and has activity against a broad range of protists. Synonyms: BPH-715; BPH 715; BPH715; GTPL3196; GTPL 3196; GTPL-3196; Bisphpshonate-715. 3-(Decyloxy)-1-(2-hydrogen phosphonato-2-phosphonoethyl)pyridin-1-ium;Bisphpshonate-715;[2-(3-Decoxypyridin-1-ium-1-yl)-1-phosphonoethyl]-hydroxyphosphinate;Hydrogen (2-(3-(decyloxy)pyridin-1-ium-1-yl)-1-phosphonoethyl)phosphonate. Grades: >98%. CAS No. 1059677-23-4. Molecular formula: C17H31NO7P2. Mole weight: 423.38. | |
| casbene synthase | The enzyme from castor bean (Ricinus communis) produces the antifungal diterpene casbene. Group: Enzymes. Synonyms: casbene synthetase; geranylgeranyl-diphosphate diphosphate-lyase (cyclizing). Enzyme Commission Number: EC 4.2.3.8. CAS No. 69106-45-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5242; casbene synthase; EC 4.2.3.8; 69106-45-2; casbene synthetase; geranylgeranyl-diphosphate diphosphate-lyase (cyclizing). Cat No: EXWM-5242. | |
| chlorophyll synthase | Requires Mg2+. The enzyme is modified by binding of the first substrate, phytyl diphosphate, before reaction of the modified enzyme with the second substrate, chlorophyllide a, can occur. The reaction also occurs when phytyl diphosphate is replaced by geranylgeranyl diphosphate. Group: Enzymes. Enzyme Commission Number: EC 2.5.1.62. CAS No. 9077-8-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2800; chlorophyll synthase; EC 2.5.1.62; 9077-08-1. Cat No: EXWM-2800. | |
| farnesylcysteine lyase | A flavoprotein (FAD). In contrast to mammalian EC 1.8.3.5 (prenylcysteine oxidase) the farnesylcysteine lyase from Arabidopsis is specific for S-farnesyl-L-cysteine and shows no activity with S-geranylgeranyl-L-cysteine. Group: Enzymes. Synonyms: FC lyase; FCLY. Enzyme Commission Number: EC 1.8.3.6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1663; farnesylcysteine lyase; EC 1.8.3.6; FC lyase; FCLY. Cat No: EXWM-1663. | |
| FGTI-2734 | FGTI-2734 is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor. It can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors. Uses: Designed for use in research and industrial production. Additional or Alternative Names: FGTI-2734; FGTI2734; FGTI 2734. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1247018-19-4. Molecular formula: C26H31FN6O2S. Mole weight: 510.63. Purity: >98%. IUPACName: N-(2-((4-cyano-2-fluorophenyl)((1-methyl-1H-imidazol-5-yl)methyl)amino)ethyl)-N-(cyclohexylmethyl)pyridine-2-sulfonamide. Canonical SMILES: O=S(C1=NC=CC=C1)(N(CC2CCCCC2)CCN(CC3=CN=CN3C)C4=CC=C(C=C4F)C#N)=O. Product ID: ACM1247018194. Alfa Chemistry ISO 9001:2015 Certified. |  |
| FTase Inhibitor I | FTase inhibitor I is a potent and selective farnesyltransferase (FTase) inhibitor with an IC50 of 21 nM, which is 30-fold higher for FTase over geranylgeranyl transferase (GGTase; IC50 = 790 nM). Synonyms: Farnesyltransferase Inhibitor I; B581; N-[(2S)-2-[[(2R)-2-amino-3-mercaptopropyl]amino]-3-methylbutyl]-L-phenylalanyl-L-methionine. Grades: ≥95%. CAS No. 149759-96-6. Molecular formula: C22H38N4O3S2. Mole weight: 470.69. | |
| FTase Inhibitor II | FTase Inhibitor II is a cell-permeable analog of farnesyl pyrophosphate (FPP) that potently inhibits FTase with an IC50 of 50-75 nM, and it does not inhibit geranylgeranyl transferase at similar concentrations (IC50 > 100 μM). FTase Inhibitor II is a possible cancer therapeutic agent. Synonyms: Farnesyltransferase Inhibitor II; FTI-II; N-[4-[[(2R)-2-amino-3-mercapto-1-oxopropyl]amino]benzoyl]-L-methionine. Grades: ≥80%. CAS No. 156707-43-6. Molecular formula: C15H21N3O4S2. Mole weight: 371.47. | |
| FTI 276 trifluoroacetate salt | FTI 276 is a Ras CAAX peptidomimetic, a selective inhibitor of farnesyltransferase (FTase) with > 100-fold selectivity over geranylgeranyltransferase I (GGTase I) (IC50 = 0.5 and 50 nM, respectively). It exhibits an inhibitory effect on growth of human lung carcinoma expressing oncogenic K-Ras in nude mice. Synonyms: FTI 276 trifluoroacetate salt; FTI276 trifluoroacetate salt; FTI-276 trifluoroacetate salt; N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine trifluoroacetate salt. Grades: ≥95% by HPLC. CAS No. 1217471-51-6. Molecular formula: C21H27N3O3S2.C2HF3O2. Mole weight: 547.61. | |
| FTI-277 | FTI-277, a peptide mimetic of the COOH-terminal Cys-Val-Ile-Met of K-Ras4B that inhibited potently FTase in vitro (IC50 = 500 pM) and was highly selective for FTase over geranylgeranyltransferase I (GGTase I) (IC50 = 50 nM). FTI-277, the methyl ester derivative of FTI-276, was extremely potent (IC50 = 100 nM) at inhibiting H-Ras, but not the geranylgeranylated Rap1A processing in whole cells. Treatment of H-Ras oncogene-transformed NIH 3T3 cells with FTI-277 blocked recruitment to the plasma membrane and subsequent activation of the serine/threonine kinase c-Raf-1 in cells transformed by farnesylated Ras (H-RasF), but not geranylgeranylated, Ras (H-RasGG). FTI-277 induced accumulation of cytoplasmic non-farnesylated H-Ras that was able to bind Raf and form cytoplasmic Ras/Raf complexes in which Raf kinase was not activated. Furthermore, FTI-277 blocked constitutive activation of mitogen-activated protein kinase (MAPK) in H-RasF, but not H-RasGG, or Raf-transformed cells. FTI-277 also inhibited oncogenic K-Ras4B processing and constitutive activation of MAPK, but the concentrations required were 100-fold higher than those needed for H-Ras inhibition. The results demonstrate that FTI-277 blocks Ras oncogenic signaling by accumulating inactive Ras/Raf complexes in the cytoplasm, hence preventing constitutive activation of the MAPK cascade. Uses: Radiation-sensitizing agents. Synonyms: FTI-277; FTI 277; FTI277. CAS No. 170006-73-2. Molecular formula: C22H29N3O3S2. Mole weight: 447.612. | |
| FTI 277 HCl | FTI-277 inhibits Ras processing with an IC50 of 100 nM, but not the geranylgeranylated Rap1A processing in whole cells. Synonyms: FTI277 HCl; FTI 277 HCl; FTI-277 HCl. Grades: >98%. CAS No. 180977-34-8. Molecular formula: C22H30ClN3O3S2. Mole weight: 484.07. | |
| geranylfarnesyl diphosphate synthase | The enzyme from Methanosarcina mazei is involved in biosynthesis of the polyprenyl side-chain of methanophenazine, an electron carrier utilized for methanogenesis. It prefers geranylgeranyl diphosphate and farnesyl diphosphate as allylic substrate. The enzyme from Aeropyrum pernix prefers farnesyl diphosphate as allylic substrate. The enzyme is involved in the biosynthesis of C25-C25 membrane lipids. Group: Enzymes. Synonyms: FGPP synthase; (all-E) geranylfarnesyl diphosphate synthase; GFPS; Fgs. Enzyme Commission Number: EC 2.5.1.81. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2819; geranylfarnesyl diphosphate synthase; EC 2.5.1.81; FGPP synthase; (all-E) geranylfarnesyl diphosphate synthase; GFPS; Fgs. Cat No: EXWM-2819. | |
| GGTI 2133 trifluoroacetate salt | GGTI 2133 is a peptidomimetic inhibitor of geranylgeranyl transferase type I (GGTase I) with an IC50 value of 38 nM, whch is 140-fold selective for GGTase I over farnesyltransferase (IC50 = 5,400 nM). Synonyms: N-[4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthalenyl)benzoyl]-L-leucine, 2,2,2-trifluoroacetate salt. Grades: ≥95%. CAS No. 1217480-14-2. Molecular formula: C27H28N4O3·xCF3COOH. Mole weight: 456.54. | |
| GGTI-2154 | GGTI-2154 is a geranylgeranyltransferase I (GGTase I) inhibitor. GGTI-2154 results not only in halting the growth of aggressive breast tumors but actually in inducing the regression (54 +/- 3%) of all 19 tumors analyzed. The farnesyltransferase (FTase) inhibitor FTI-2148 induced an average of 87 +/- 3% regression in the 13 tumors analyzed. GGTase I, but not FTase, is inhibited in breast tumors after treatment with GGTI-2154, whereas in tumors from mice treated with FTI-2148, only FTase is inhibited. The processing of the geranylgeranylated proteins RhoA, Rap1, and R-Ras, but not the farnesylated proteins H-Ras and HDJ-2, is inhibited in tumors obtained from mice treated with GGTI-2154. GGTI-2154 and FTI-2148 suppress constitutively activated phospho-Erk1/2 and phospho-Akt, induce apoptosis, and induce differentiation toward ductolobular breast epithelium. Synonyms: GGTI-2154; GGTI 2154; GGTI2154. Grades: 98%. CAS No. 251577-10-3. Molecular formula: C24H28N4O3. Mole weight: 420.51. | |
| GGTI-2166 | GGTI-2166 is a geranylgeranyl transferase I inhibitor. GGTI-2166 inhibit the pOC formation induced by RANKL or TNF-alpha in cultures of both mouse marrow-derived macrophage-colony-stimulating factor (M-CSF) dependent monocytes (MD cells) and the mouse monocyte cell line RAW 264.7 (RAW cells). GGTI-2166 inhibited TRAP activity induced by RANKL or TNF-alpha in both cell cultures and prevented the incorporation of [3H]all-trans geranylgeraniol into prenylated proteins in RAW cells. Synonyms: GGTI2166; GGTI2166. Grades: 98%. CAS No. 478908-51-9. Molecular formula: C25H30N4O3. Mole weight: 434.53. | |
| GGTI-2418 | GGTI-2418 is a synthetic peptidomimetic inhibitor of geranylgeranyltransferase I (GGTase I) that appears to induce apoptosis by downregulating several pivotal oncogenic and tumor survival pathways. GGTase I catalyzes the lipid posttranslational modification which is required for the function of Rho GTPases (frequently found aberrantly activated in human cancer). GGTase I inhibitors block Rho function in cancer cells and induce a G1 phase cell cycle arrest by a mechanism involving induction of the CDK inhibitors p21waf and p27kip, CDK2 and CDK4 inhibition and hypophoshorylation of the tumor suppressor Rb. GGTase I inhibitors also induce apoptosis by a mechanism involving downregulation of the expression of survivin and suppression of the activation of PI3K/Akt. Synonyms: GGTI 2418; GGTI-2418; GGTI 2418. CAS No. 501010-06-6. Molecular formula: C23H31N5O4. Mole weight: 441.532. | |
| GGTI 286 trifluoroacetate salt | GGTI 286 is a cell permeable and potent inhibitor of geranylgeranyltransferase I (GGTase I) that selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s = 2 and >30 μM, respectively). Synonyms: N-[[5-[[(2R)-2-amino-3-mercaptopropyl]amino][1,1'-biphenyl]-2-yl]carbonyl]-L-leucine, methyl ester, trifluoroacetate salt. Grades: ≥90%. Molecular formula: C23H31N3O3S·2CF3COOH. Mole weight: 657.62. | |
| GGTI-298 | GGTI-298 is a selective geranylgeranyltransferase type I inhibitor that displays little effect on other prenylation enzymes such as farnesyltransferase. GGTI-298 causes G0-G1 cell cycle block and apoptosis in A549 cells (IC50 = 10 μM for A549 cells) and inhibits cell invasion and migration in COLO 320CM cells. Synonyms: methyl (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropyl]amino]-2-naphthalen-1-ylbenzoyl]amino]-4-methylpentanoate; GGTI 298; GGTI298; GGTI-298; N-4-[2(R)-Amino-3-mercaptopropyl]amino-2-naphthylbenzoyl-(L)-Leucine methyl ester, TFA; (S)-methyl 2-(4-(((R)-2-amino-3-mercaptopropyl)amino)-2-(naphthalen-1-yl)benzamido)-4-methylpentanoate. CAS No. 180977-44-0. Molecular formula: C27H33N3O3S. Mole weight: 479.63. | |
| GGTI298 Trifluoroacetate | GGTI298 Trifluoroacetate is a CAAZ peptidomimetic geranylgeranyltransferase I ( GGTase I ) inhibitor, which can inhibit Rap1A with IC 50 of 3 μM; little effect on Ha-Ras with IC 50 of >20 μM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1217457-86-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15871. | |
| GGTI 298 (trifluoroacetate salt) | GGTI-298 is a selective geranylgeranyltransferase type I inhibitor that displays little effect on other prenylation enzymes such as farnesyltransferase. GGTI-298 causes G0-G1 cell cycle block and apoptosis in A549 cells (IC50 = 10 μM for A549 cells) and inhibits cell invasion and migration in COLO 320CM cells. Synonyms: methyl (4-(((R)-2-amino-3-mercaptopropyl)amino)-2-(naphthalen-1-yl)benzoyl)-L-leucinate 2,2,2-trifluoroacetate; GGTI-298 TFA; GGTI-298 trifluoride salt; GGTI-298; GGTI 298; GGTI298. CAS No. 1217457-86-7. Molecular formula: C27H33N3O3S.CF3COOH. Mole weight: 593.7. | |
| hexaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] | The enzyme prefers farnesyl diphosphate to geranylgeranyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and dimethylallyl diphosphate. Group: Enzymes. Synonyms: HexPS (ambiguous); hexaprenyl pyrophosphate synthetase (ambiguous); hexaprenyl diphosphate synthase (ambiguous). Enzyme Commission Number: EC 2.5.1.83. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2821; hexaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]; EC 2.5.1.83; HexPS (ambiguous); hexaprenyl pyrophosphate synthetase (ambiguous); hexaprenyl diphosphate synthase (ambiguous). Cat No: EXWM-2821. | |
| homogentisate phytyltransferase | Requires Mg2+ for activity. Involved in the biosynthesis of the vitamin E tocopherols. While the enzyme from the cyanobacterium Synechocystis PCC 6803 has an appreciable activity with geranylgeranyl diphosphate (EC 2.5.1.116, homogentisate geranylgeranyltransferase), the enzyme from the plant Arabidopsis thaliana has only a low activity with that substrate. Group: Enzymes. Synonyms: HPT; VTE2 (gene name). Enzyme Commission Number: EC 2.5.1.115. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2731; homogentisate phytyltransferase; EC 2.5.1.115; HPT; VTE2 (gene name). Cat No: EXWM-2731. | |
| Menaquinone 4 | Menaquinone 4. Group: Biochemicals. Alternative Names: (E,E,E)-2-Methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthalenedione; 2-Methyl-3-geranylgeranyl-1,4-naphthoquinone; Glakay. Grades: Highly Purified. CAS No. 863-61-6. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C31H40O2. US Biological Life Sciences. | Worldwide |
| Menaquinone 4 | Menaquinone 4 is a homolog of vitamin K2 with four isoprene residue in its side chain. Menaquinone 4 is the most common type of vitamin K2 and can be used for the pain of osteoporosis. Uses: Hemostatics. Synonyms: 1,4-Naphthalenedione, 2-methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl]-; 1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-, (E,E,E)-; 1,4-Naphthalenedione, 2-methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl]-; 2-Methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl]-1,4-naphthalenedione; 2-Methyl-3-geranylgeranyl-1,4-naphthoquinone; Glakay; K-viton; Kaytwo; Menaquinone K4; Menatetrenone; MK-4; Vitamin K2; Vitamin K2(20); Vitamin K2-4; Vitamin MK 4. Grades: ≥95%. CAS No. 863-61-6. Molecular formula: C31H40O2. Mole weight: 444.65. | |
| Menaquinone 4-d7 (Mixture of cis-trans isomers) | Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a variety of physiological processes. Menaquinone 4-d7 is the labeled analogue of Menaquinone 4. Menaquinone-4 is the most common type of vitamin K2 and is known as a hemostatic agent and is used as adjunctive therapy for the pain of osteoporosis. Group: Biochemicals. Alternative Names: (E,E,E)-2-Methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthalenedione-d7; 2-Methyl-3-geranylgeranyl-1,4-naphthoquinone-d7; Glakay-d7; Kaytwo-d7; MK4-d7; Menaquinone K4-d7; Menatetrenone-d7; Vitamin K2(20)-d7; Vitamin MK 4-d7. Grades: Highly Purified. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| Menaquinone 4 (Mixture of cis-trans isomers) | Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a variety of physiological processes. Menaquinone 4 has four isoprene residue in its side chain and is also commonly refered to as menatetrenone. Menaquinone-4 is the most common type of vitamin K2 and is known as a hemostatic agent and is used as adjunctive therapy for the pain of osteoporosis. Group: Biochemicals. Alternative Names: (E,E,E)-2-Methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthalenedione; 2-Methyl-3-geranylgeranyl-1,4-naphthoquinone; Glakay; Kaytwo; MK4; Menaquinone K4; Menatetrenone; Vitamin K2(20); Vitamin MK 4. Grades: Highly Purified. CAS No. 863-61-6. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| prenylcysteine oxidase | A flavoprotein (FAD). Cleaves the thioether bond of S-prenyl-L-cysteines, such as S-farnesylcysteine and S-geranylgeranylcysteine. N-Acetyl-prenylcysteine and prenylcysteinyl peptides are not substrates. May represent the final step in the degradation of prenylated proteins in mammalian tissues. Originally thought to be a simple lyase so it had been classified as EC 4.4.1.18. Group: Enzymes. Synonyms: prenylcysteine lyase. Enzyme Commission Number: EC 1.8.3.5. CAS No. 196717-99-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1662; prenylcysteine oxidase; EC 1.8.3.5; 196717-99-4; prenylcysteine lyase. Cat No: EXWM-1662. | |
| Prenyl-IN-1 | Prenyl-IN-1 is a protein prenylation inhibitor, especially a geranylgeranyltransferase (GGT) or a farnesyltransferase (FT) inhibitor. Synonyms: Benzonitrile, 4-[[5-[[4-(3-chlorophenyl)-3-oxo-1-piperazinyl]methyl]-1H-imidazol-1-yl]methyl]-2-phenoxy-. CAS No. 360561-53-1. Molecular formula: C28H24ClN5O2. Mole weight: 497.98. | |
| protein farnesyltransferase | This enzyme, along with protein geranylgeranyltransferase types I (EC 2.5.1.59) and II (EC 2.5.1.60), constitutes the protein prenyltransferase family of enzymes. Catalyses the formation of a thioether linkage between the C-1 of an isoprenyl group and a cysteine residue fourth from the C-terminus of the protein. These protein acceptors have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably serine, methionine, alanine or glutamine; leucine makes the protein a substrate for EC 2.5.1.59. The enzymes are relaxed in specificity for A1, but cannot act if A2 is aromatic. Substrates of the prenyltransferases include Ras, Rho, Rab, other Ras-related small GTP-binding proteins, γ-subunits of heterotrimeric G-proteins, nuclear lamins, centromeric proteins and many proteins involved in visual signal transduction. A zinc metalloenzyme that requires Mg2+ for activity. Group: Enzymes. Synonyms: FTase. Enzyme Commission Number: EC 2.5.1.58. CAS No. 131384-38-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2795; protein farnesyltransferase; EC 2.5.1.58; 131384-38-8; FTase. Cat No: EXWM-2795. | |
| protein-S-isoprenylcysteine O-methyltransferase | C-terminal S-geranylgeranylcysteine and S-geranylcysteine residues are also methylated, but more slowly. Group: Enzymes. Synonyms: farnesyl cysteine C-terminal methyltransferase; farnesyl-protein carboxymethyltransferase; protein C-terminal farnesylcysteine O-methyltransferase; farnesylated protein C-terminal O-methyltransferase; isoprenylated protein methyltransferase; prenylated protein methyltransferase; protein S-farnesylcysteine C-terminal methyltransferase; S-farnesylcysteine methyltransferase; prenylcysteine carboxylmethyltra. Enzyme Commission Number: EC 2.1.1.100. CAS No. 130731-20-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1698; protein-S-isoprenylcysteine O-methyltransferase; EC 2.1.1.100; 130731-20-3; farnesyl cysteine C-terminal methyltransferase; farnesyl-protein carboxymethyltransferase; protein C-terminal farnesylcysteine O-methyltransferase; farnesylated protein C-terminal O-methyltransferase; isoprenylated protein methyltransferase; prenylated protein methyltransferase; protein S-farnesylcysteine C-terminal methyltransferase; S-farnesylcysteine methyltransferase; prenylcysteine carboxylmethyltransferase [misleading]; prenylcysteine carboxymethyltransferase [misleading]; prenylcysteine methyltransferase. Cat No: EXWM-1698. | |
| Psoromic acid | Psoromic acid is a potent and selective RabGGTase (Rab geranylgeranyl transferase) inhibitor with an IC 50 value of 1.3 μM. Psoromic acid is an antioxidative agent. Psoromic acid exhibits a competitive type of HMGR inhibition and mixed type of ACE (angiotensin converting enzyme) inhibition [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Parellic acid. CAS No. 7299-11-8. Pack Sizes: 500 μg. Product ID: HY-130199. | |
| Psoromic acid | Psoromic acid is a selective inhibitor of Rab geranylgeranyl transferase and P. falciparum fatty acid synthesis (FAS) II enzymes. Synonyms: 10-formyl-9-hydroxy-3-methoxy-4,7-dimethyl-6-oxobenzo[b][1,4]benzodioxepine-1-carboxylic acid; NSC 92186; Parellic Acid; Psoromsaeure; Sulcatic acid; Sqamaric. Grades: ≥95%. CAS No. 7299-11-8. Molecular formula: C18H14O8. Mole weight: 358.30. | |
| R-linalool synthase | Geranyl diphosphate cannot be replaced by isopentenyl diphosphate, dimethylallyl diphosphate, farnesyl diphosphate or geranylgeranyl diphosphate as substrate. Requires Mg2+ or Mn2+ for activity. Unlike many other monoterpene synthases, only a single product, (3R)-linalool, is formed. Group: Enzymes. Synonyms: (3R)-linalool synthase; (-)-3R-linalool synthase. Enzyme Commission Number: EC 4.2.3.26. CAS No. 254993-26-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5183; R-linalool synthase; EC 4.2.3.26; 254993-26-5; (3R)-linalool synthase; (-)-3R-linalool synthase. Cat No: EXWM-5183. | |
| sclareol synthase | Isolated from the plant Salvia sclarea (clary sage). Originally thought to be synthesized in one step from geranylgeranyl diphosphate it is now known to require two enzymes, EC 4.2.1.133, copal-8-ol diphosphate synthase and EC 4.2.3.141, sclareol synthase. Sclareol is used in perfumery. Group: Enzymes. Synonyms: SS. Enzyme Commission Number: EC 4.2.3.141. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5155; sclareol synthase; EC 4.2.3.141; SS. Cat No: EXWM-5155. | |
| S-Farnesyl thioacetic acid | S-Farnesyl thioacetic acid has shown inhibitory effects against methylation of both farnesylated and geranylgeranylated substrates. It also inhibits Ca2+ influx through non-voltage-gated Ca2+ channels. Synonyms: FTA; [(3,7,11-trimethyldodeca-2,6,10-trien-1-yl)sulfanyl]acetic acid; Farnesylthoiacetic acid. Grades: ≥97%. CAS No. 135784-48-4. Molecular formula: C17H28O2S. Mole weight: 296.5. | |
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