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| Product | Description | |
|---|---|---|
| Gliotoxin | Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus , inhibits the phagocytosis of macrophages and the immune functions of other immune cells [1]. Gliotoxin inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis [2]. Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells [3]. Gliotoxin is a potent NOTCH2 transactivation inhibitor, can effectively induce apoptosis of chronic lymphocytic leukemia (CLL) cells [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Aspergillin. CAS No. 67-99-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N6727. |  |
| Gliotoxin | Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells. Gliotoxin inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis. Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Aspergillin. Product Category: Inhibitors. Appearance: White lyophilized solid. CAS No. 67-99-2. Molecular formula: C13H14N2O4S2. Mole weight: 326.4. Purity: 0.98. IUPACName: (1R,7S,8S,11R)-7-hydroxy-11-(hydroxymethyl)-15-methyl-12,13-dithia-9,15-diazatetracyclo[9.2.2.01,9.03,8]pentadeca-3,5-diene-10,14-dione. Canonical SMILES: CN1C(=O)[C@]23CC4=CC=C[C@@H]([C@H]4N2C(=O)[C@]1(SS3)CO)O. Product ID: ACM67992. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Gliotoxin | Gliotoxin is a sulfur-containing mycotoxin produced by species of fungi and pathogens of humans. Gliotoxin exhibits inhibitory activities against histone H3K9 methyltransferase, a key enzyme in the regulation of transcriptional activity by writing epigenetic marks. Gliotoxin also exhibits immunosuppressive properties by causing apoptosis of cells of the immune system. In addition, various studies suggests Gliotoxin may also be a potential anti-inflammatory, antibiotic, antifungal and antiviral agent. Group: Biochemicals. Alternative Names: (3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dione. Grades: Highly Purified. CAS No. 67-99-2. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Gliotoxin | It is produced by the strain of Gliocladium fimbriatum, Trichoderma lignorum, Penicillum cineroscens. It has the activity of anti-gram positive bacterium, negative bacterium, fusarium oxysporum, endosporium, ringworm fungus and other fungi, and has the effect of inhibiting poliovirus. Uses: Immunosuppressive agents. Synonyms: Aspergillin; SN 12879; SN 12870; 10H-3,10a-Epidithiopyrazino(1,2-a)indole-1,4-dione,2,3,5a,6-tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-; (3R,5aS,6S,10aR)-6-hydroxy-3-(hydroxymethyl)-2-methyl-2,3,5a,6-tetrahydro-10H-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dion. Grades: >99% by HPLC. CAS No. 67-99-2. Molecular formula: C13H14N2O4S2. Mole weight: 326.39. |  |
| 6-Acetylbisdethiobis (methylthio)gliotoxin | It is a natural product first produced by the strain of the fungus D. cejpii. It shows anti-inflammatory properties and inhibits TNF-α-induced NF-κB activity. Synonyms: 6-acetylbis (dethio)bis (methylsulfanyl)gliotoxin; (3R,5aS,6S,10aR)-1,2,3,4,5a,6,10,10a-octahydro-3-(hydroxymethyl)-2-methyl-3,10a-bis(methylsulfanyl)-1,4-dioxopyrazino[1,2-a]indol-6-yl acetate; 6-acetylbis(methylthio)gliotoxin. CAS No. 146016-65-1. Molecular formula: C17H22N2O5S2. Mole weight: 398.50. | |
| Cyclo(-L-Phe-L-Ser) | An intermediate in the biosynthesis of gliotoxin. Synonyms: Cyclo(-Phe-Ser). Grades: ≥ 98% (HPLC). CAS No. 35591-00-5. Molecular formula: C12H14N2O3. Mole weight: 234.25. | |
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