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| Product | Description | |
|---|---|---|
| Glucocorticoid receptor agonist | Glucocorticoid receptor agonist is a Glucocorticoid receptor agonist that acts on Glucocorticoid receptor ( GR ), progesterone receptor ( PR ) and mineralocorticoid receptor ( MR ) with the IC 50 values of 2.1 , 1200 and 210 nM, respectively. Glucocorticoid receptor agonist has steroid-like anti-inflammatory properties and may be used to improve metabolism and reduce increased levels of body fat and serum insulin [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1245526-82-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-14234. |  |
| Glucocorticoid receptor agonist | Glucocorticoid receptor agonist is an effective Glucocorticoid receptor agonist and probably has steroid-like anti-inflammatory properties. Uses: Glucocorticoid receptor agonist is an effective glucocorticoid receptor agonist and probably has steroid-like anti-inflammatory properties. Synonyms: 4-fluoro-2-[(4R)-5, 5, 5-trifluoro-4-hydroxy-2-methyl-4-(1H-pyrrolo[2, 3-c]pyridin-2-ylmethyl)pentan-2-yl]phenol; Glucocorticoidreceptoragonist; CHEMBL1253898; 1245526-82-2; C20H20F4N2O2; 3695AH. Grades: 95%. CAS No. 1245526-82-2. Molecular formula: C20H20F4N2O2. Mole weight: 396.38. |  |
| Glucocorticoid receptor agonist-1 | Glucocorticoid receptor agonist-1 is a potent glucocorticoid receptor agonist with an IC 50 of 2.8 nM extracted from patent WO2017210471A1, compound 41 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2166375-82-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131974. | |
| Glucocorticoid receptor agonist-2 | Glucocorticoid receptor agonist-2 (compound 21) is an glucocorticoid receptor agonist with an IC 50 value of 6.6 nM. Glucocorticoid receptor agonist-2 can be used to synthesize anti-inflammatory ADC molecules. Glucocorticoid receptor agonist-2 is an active reference of ABBV-3373 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2166378-92-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148435. | |
| Glucocorticoid receptor agonist-3 | Glucocorticoid receptor agonist-3 (Preparation 6) is a glucocorticoid receptor agonist [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2842165-73-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-160177. | |
| (11β)-9-Fluoro-11-hydroxy-16-methyl-3-oxo-androsta-1,4,16-triene-17-carboxylic Acid | (11β)-9-Fluoro-11-hydroxy-16-methyl-3-oxo-androsta-1,4,16-triene-17-carboxylic Acid is one of Clobetasol propionate impurities. Clobetasol propionate is a glucocorticoid that induces monooxygenase activity in vivo. It alters the structure of tight junctions in epidermis and smoothened hedgehog pathway receptor agonist. It can be used as an anti-inflammatory, immunosuppressive and antimitotic agent. Active in vivo. CAS No. 59861-00-6. Molecular formula: C21H25FO4. Mole weight: 360.42. | |
| 21-Deschloro Clobetasol 17-Propionate | 21-Deschloro Clobetasol 17-Propionate is one of Clobetasol propionate impurities. Clobetasol propionate is a glucocorticoid that induces monooxygenase activity in vivo. It alters the structure of tight junctions in epidermis and smoothened hedgehog pathway receptor agonist. It can be used as anti-inflammatory, immunosuppressive and antimitotic agent. Active in vivo. Synonyms: 9-Fluoro-11β,17-dihydroxy-16β-methyl-pregna-1,4-diene-3,20-dione 17-Propionate; (11β,16β)-9-Fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione; Clobetasol Propionate EP Impurity H. Grades: 98%. CAS No. 4351-48-8. Molecular formula: C25H33FO5. Mole weight: 432.52. | |
| 2,2,2-Trifluoroethyl Isocyanate | 2,2,2-Trifluoroethyl Isocyanate is an intermediate used to prepare PDE5 inhibitors for erectile dysfunction. It is also used to synthesize indazolyl glucocorticoid receptor partial agonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 371-92-6. Pack Sizes: 1g, 10g. Molecular Formula: C3H2F3NO. US Biological Life Sciences. |  Worldwide |
| 2-Chloro-3-fluorobenzoic Acid | 2-Chloro-3-fluorobenzoic Acid is a useful synthetic intermediate. It can be used to synthesize aminobenzhydrol derivatives containing pendant cyclic amines as inhibitors of squalene synthase and cholesterol synthase. It can also be used to prepare aryl aminopyrazole benzamides as oral non-steroidal selective glucocorticoid receptor agonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 102940-86-3. Pack Sizes: 2.5g, 5g. Molecular Formula: C7H4ClFO2, Molecular Weight: 174.56. US Biological Life Sciences. | Worldwide |
| 9α-Fluoro-11β-hydroxy-16-β-methyl-3-oxoandrosta-1,4-diene-17(R)-spiro-2'-[4'-chloro-5'-ethylfuran-3'(2'H)-one | 9α-Fluoro-11β-hydroxy-16-β-methyl-3-oxoandrosta-1,4-diene-17(R)-spiro-2'-[4'-chloro-5'-ethylfuran-3'(2'H)-one is one of Clobetasol propionate impurities. Clobetasol propionate is a glucocorticoid that induces monooxygenase activity in vivo. It alters the structure of tight junctions in epidermis and smoothened hedgehog pathway receptor agonist. It can be used as an anti-inflammatory, immunosuppressive and antimitotic agent. Active in vivo. Synonyms: (2'R,8S,9R,10S,11S,13S,14S,16S)-4'-chloro-5'-ethyl-9-fluoro-11-hydroxy-10,13,16-trimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,3'(6H)-dione; Clobetasol Propionate EP Impurity J; (17R)-4'-Chloro-5'-ethyl-9-fluoro-11beta-hydroxy-16beta-methylspiro[androsta-1,4-diene-17,2'(3'H)-furan]-3,3'-dione; Clobetasol Propionate USP Related Compound A. Grades: ≥ 95%. CAS No. 1486466-31-2. Molecular formula: C25H30ClFO4. Mole weight: 448.95. | |
| ACTH (1-39) (Human) | Potent endogenous melanocortin receptor 2 (MC2) agonist (EC50 = 57 pM). Component of the hypothalamic-pituitary-adrenal (HPA) axis that stimulates glucocorticoid production and release from the adrenal cortex. Induces insulin resistance, promotes a proinflammatory profile and stimulates UCP-1 in adipocytes in vitro. Group: Biochemicals. Alternative Names: Adrenocorticotropic hormone (1-39); Adrenocorticotropin; Corticotropin. Grades: Highly Purified. CAS No. 12279-41-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Beclometasone | Beclometasone (Beclomethasone) is a prototype glucocorticoid receptor agonist. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Beclomethasone. CAS No. 4419-39-0. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-B1540. | |
| Beclometasone dipropionate | Beclometasone dipropionate, the proagent of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate can be used for asthma [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Beclomethasone dipropionate. CAS No. 5534-9-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-13571A. | |
| Beclometasone dipropionate (Standard) | Beclometasone dipropionate (Standard) is the analytical standard of Beclometasone dipropionate. This product is intended for research and analytical applications. Beclometasone dipropionate, the proagent of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate can be used for asthma [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Beclomethasone dipropionate (Standard). CAS No. 5534-9-8. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-13571AR. | |
| Beclomethasone Dipropionate Impurity B | Beclomethasone Dipropionate Impurity B is an impurity of beclomethasone dipropionate which known for its role as a glucocorticoid receptor agonist and extensively employed for treating respiratory conditions including asthma and allergies. Synonyms: Beclomethasone 21-acetate 17-propionate; (11β,16β)-21-(acetyloxy)-9-chloro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione; 9-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-Acetate 17-Propionate. Grades: > 95%. CAS No. 5534-8-7. Molecular formula: C27H35ClO7. Mole weight: 507.03. | |
| Beclomethasone Dipropionate Impurity D | Beclomethasone Dipropionate Impurity D is an impurity retrieved from Beclomethasone Dipropionate, an efficacious glucocorticoid receptor agonist serving as an invaluable therapeutic intervention for an assortment of inflammatory respiratory ailments, notably asthma, chronic obstructive pulmonary disease (COPD) and allergic rhinitis. Synonyms: 9-bromo Beclomethasone Dipropionate; (11β,16β)-9-BroMo-11-hydroxy-16-Methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione. Grades: > 95%. CAS No. 52092-14-5. Molecular formula: C28H37BrO7. Mole weight: 565.51. | |
| Betamethasone hydrochloride | Betamethasone hydrochloride is the hydrochloride of betamethasone, which is a synthetic corticosteroid and agonist of glucocorticoid receptor. It does not cause water retention. It has shown the inflammatory response by the betamethasone-receptor complex modulated the activity of certain genes, altering the production and activity of proteins. It has also revealed to inhibit keratinocyte proliferation. It has anti-inflammatory and immunosuppressive properties. Uses: Betamethasone hydrochloride inhibits keratinocyte proliferation. it has anti-inflammatory and immunosuppressive properties. Grades: >98 %. CAS No. 956901-32-9. Molecular formula: C22H30ClFO5. Mole weight: 428.92. | |
| Biotinyl-ACTH (1-39) (human) | ACTH (1-39) is a melanocortin receptor agonist that stimulates the adrenal cortex and the secretion of glucocorticoids, such as cortisol. Synonyms: Biotin-ACTH (1-39), Human; Biotinyl-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe-OH. Grades: ≥95% by HPLC. CAS No. 1816258-26-0. Molecular formula: C217H322N58O60S2. Mole weight: 4767.43. | |
| Budesonide | Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 51333-22-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-13580. | |
| Budesonide (Standard) | Budesonide (Standard) is the analytical standard of Budesonide. This product is intended for research and analytical applications. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 51333-22-3. Pack Sizes: 10 mg; 25 mg; 50 mg. Product ID: HY-13580R. | |
| CHF-6162 | CHF-6162 is an agonist of glucocorticoid receptor (GR) (IC50 = 0.24nM), which shows greater potency than fluticasone and budesonide in a radioligand binding assay. Uses: The potential teatment of airway inflammation. Synonyms: CHF-6162; CHF 6162; CHF6162. | |
| Clobetasol Propionate | Clobetasol propionate is a glucocorticoid that induces monooxygenase activity in vivo. It alters the structure of tight junctions in epidermis and smoothened hedgehog pathway receptor agonist. It can be used as anti-inflammatory, immunosuppressive and antimitotic agent. Active in vivo. Uses: Anti-inflammatory, immunosuppressive and antimitotic agent. Synonyms: Clobex; Cosvate (India); Temovate (US); Olux; Tenovate; Dermovate; Dermatovate; Butavate; Movate; Novate; [17-(2'-chloroacetyl)- 9-fluoro-11-hydroxy-10,13,16-trimethyl- 3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate. Grades: 0.99. CAS No. 25122-46-7. Molecular formula: C25H32ClFO5. Mole weight: 466.974. | |
| Clobetasol Propionate EP Impurity E | Clobetasol Propionate EP Impurity E is one of Clobetasol propionate impurities. Clobetasol propionate is a glucocorticoid that induces monooxygenase activity in vivo. It alters the structure of tight junctions in epidermis and smoothened hedgehog pathway receptor agonist. It can be used as an anti-inflammatory, immunosuppressive and antimitotic agent. Active in vivo. Molecular formula: C25H33ClO4. Mole weight: 432.98. | |
| Clobetasol Propionate EP Impurity F Ethyl Ester | Clobetasol Propionate EP Impurity F Ethyl Ester is one of Clobetasol propionate impurities. Clobetasol propionate is a glucocorticoid that induces monooxygenase activity in vivo. It alters the structure of tight junctions in epidermis and smoothened hedgehog pathway receptor agonist. It can be used as an anti-inflammatory, immunosuppressive and antimitotic agent. Active in vivo. Synonyms: (E)-ethyl 2-((8S,9R,10S,11S,13S,14S,16S)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-7,8,9,11,12,13,15,16-octahydro-3H-cyclopenta[a]phenanthren-17(6H,10H,14H)-ylidene)acetate. Molecular formula: C24H31FO4. Mole weight: 402.50. | |
| Clobetasol Propionate Impurity 1 | Clobetasol Propionate Impurity 1 is one of Clobetasol propionate impurities. Clobetasol propionate is a glucocorticoid that induces monooxygenase activity in vivo. It alters the structure of tight junctions in epidermis and smoothened hedgehog pathway receptor agonist. It can be used as an anti-inflammatory, immunosuppressive and antimitotic agent. Active in vivo. Molecular formula: C22H27FO4. Mole weight: 374.44. | |
| Clobetasol Propionate Impurity 3 | Clobetasol Propionate Impurity 3 is one of Clobetasol propionate impurities. Clobetasol propionate is a glucocorticoid that induces monooxygenase activity in vivo. It alters the structure of tight junctions in epidermis and smoothened hedgehog pathway receptor agonist. It can be used as an anti-inflammatory, immunosuppressive and antimitotic agent. Active in vivo. Molecular formula: C25H31FO5. Mole weight: 430.51. | |
| Clobetasol Propionate Impurity 4 | Clobetasol Propionate Impurity 4 is one of Clobetasol propionate impurities. Clobetasol propionate is a glucocorticoid that induces monooxygenase activity in vivo. It alters the structure of tight junctions in epidermis and smoothened hedgehog pathway receptor agonist. It can be used as an anti-inflammatory, immunosuppressive and antimitotic agent. Active in vivo. Molecular formula: C22H27FO4. Mole weight: 374.44. | |
| Clobetasol Propionate Impurity 5 | Clobetasol Propionate Impurity 5 is one of Clobetasol propionate impurities. Clobetasol propionate is a glucocorticoid that induces monooxygenase activity in vivo. It alters the structure of tight junctions in epidermis and smoothened hedgehog pathway receptor agonist. It can be used as an anti-inflammatory, immunosuppressive and antimitotic agent. Active in vivo. Molecular formula: C22H30O5. Mole weight: 374.47. | |
| Clobetasol Propionate Related Compound A | Clobetasol Propionate Related Compound A is one of Clobetasol propionate impurities. Clobetasol propionate is a glucocorticoid that induces monooxygenase activity in vivo. It alters the structure of tight junctions in epidermis and smoothened hedgehog pathway receptor agonist. It can be used as an anti-inflammatory, immunosuppressive and antimitotic agent. Active in vivo. Synonyms: (17R)-4'-Chloro-5'-ethyl-9-fluoro-11beta-hydroxy-16beta-methylspiro[androsta-1,4-diene-17,2'(3'H)-furan]-3,3'-dione. Grades: 98%. Molecular formula: C25H30ClFO4. Mole weight: 448.95. | |
| Clobetasone 17-Propionate | Clobetasone 17-Propionate is one of Clobetasol propionate impurities. Clobetasol propionate is a glucocorticoid that induces monooxygenase activity in vivo. It alters the structure of tight junctions in epidermis and smoothened hedgehog pathway receptor agonist. It can be used as anti-inflammatory, immunosuppressive and antimitotic agent. Active in vivo. Synonyms: (16β)-21-Chloro-9-fluoro-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,11,20-trione; Clobetasone Propionate; 21-Chloro-9-fluoro-17-hydroxy-16β-methyl-pregna-1,4-diene-3,11,20-trione Propionate; Clobetasone Butyrate EP Impurity H; 11 Keto Clobetasol Propionate; (1R, 2S, 10S, 11S, 13S, 14R, 15S)-14-(2-Chloroacetyl)-1-fluoro-2, 13, 15-trimethyl-5, 17-dioxotetracyclo[8.7.0.02, 7.011, 15]heptadeca-3, 6-dien-14-yl propionate. Grades: 98%. CAS No. 25122-56-9. Molecular formula: C25H30ClFO5. Mole weight: 464.95. | |
| CP-394531 | CP-394531 is an effective Glucocorticoid receptor agonist and probably has steroid-like anti-inflammatory properties with anti-GR and anti-obesity activity in animal models. Uses: Glucocorticoid receptor antagonists. Synonyms: CP-394531; CP 394531; CP394531; UNII-227D9ED2SI. (2R,4aS,10aR)-4a-benzyl-2-(chloroethynyl)-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-2,7-diol. Grades: ≥95%. CAS No. 305822-63-3. Molecular formula: C23H23ClO2. Mole weight: 366.14. | |
| CP-472555 | CP-472555 is an effective Glucocorticoid receptor agonist and probably has steroid-like anti-inflammatory properties with anti-GR and anti-obesity activity in animal models. Uses: Glucocorticoid receptor antagonists. Synonyms: CP-472555; CP 472555; CP472555; UNII-6T0KV7024R. 2-Phenanthrenecarboxamide, 4b,5,6,7,8,8a,9,10-octahydro-7-hydroxy-4b-(phenylmethyl)-7-(1-propyn-1-yl)-N-(3-pyridinylmethyl)-, (4bS,7R,8aR)-. Grades: ≥95%. CAS No. 305821-96-9. Molecular formula: C31H32N2O2. Mole weight: 464.24. | |
| Dagrocorat | Dagrocorat (PF-00251802) is an orally active and selective high-affinity partial agonist of the glucocorticoid receptor. Dagrocorat is also a time-dependent reversible inhibitor of CYP3A ( IC 50 =1.3 μM in human liver microsomes) and CYP2D6 ( K i =0.57 μM in human liver microsomes). Dagrocorat can be used for the research of rheumatoid arthritis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-00251802. CAS No. 1044535-52-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16718. | |
| Dagrocorat hydrochloride | Dagrocorat (PF-00251802) hydrochloride is an orally active and selective high-affinity partial agonist of the glucocorticoid receptor. Dagrocorat hydrochloride is also a time-dependent reversible inhibitor of CYP3A ( IC 50 =1.3 μM in human liver microsomes) and CYP2D6 ( K i =0.57 μM in human liver microsomes). Dagrocorat hydrochloride can be used for the research of rheumatoid arthritis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-00251802 hydrochloride. CAS No. 1044535-61-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16718A. | |
| Dexamethasone | Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist, apoptosis inducer, and common disease inducer in experimental animals, constructing models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has potential for use in COVID-19 research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Hexadecadrol; Prednisolone F. CAS No. 50-02-2. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-14648. | |
| Dexamethasone 17α,21-Ethylorthopropionate | Dexamethasone 17α,21-Ethylorthopropionate is one of Clobetasol propionate intermediates. Clobetasol propionate is a glucocorticoid that induces monooxygenase activity in vivo. It alters the structure of tight junctions in epidermis and smoothened hedgehog pathway receptor agonist. It can be used as an anti-inflammatory, immunosuppressive and antimitotic agent. Active in vivo. Synonyms: (11β,16α)-17,21-[(1-Ethoxypropylidene)bis(oxy)]-9-fluoro-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione; 9-Fluoro-11β,17,21-trihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione Cyclic 17,21-(Ethyl Orthopropionate); 11β,17,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione. Grades: 98%. CAS No. 25122-24-1. Molecular formula: C27H37FO6. Mole weight: 476.58. | |
| Dexamethasone acetate | Dexamethasone acetate (Dexamethasone 21-acetate) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses. Uses: Designed for use in research and industrial production. Additional or Alternative Names: DEXAMETHASONE 21-ACETATE; DexaMethasone 21-Acetate; 9α-Fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-Acetate; Dexamethasone Acetate. Product Category: Inhibitors. Appearance: White or almost white crystalline powder. CAS No. 1177-87-3. Molecular formula: C24H31FO6. Mole weight: 434.5. Purity: 0.99. IUPACName: Dexamethasone-17-acetate. Canonical SMILES: C[C@@]1([C@@]2(O)C(COC(C)=O)=O)[C@](C[C@H]2C)([H])[C@@](CCC3=CC4=O)([H])[C@@](F)([C@]3(C=C4)C)[C@@H](O)C1. Density: 1.3 g/cm³. Product ID: ACM1177873. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Dexamethasone acetate | Dexamethasone acetate (Dexamethasone 21-acetate) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Dexamethasone 21-acetate; Hexadecadrol acetate. CAS No. 1177-87-3. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-14648A. | |
| Dexamethasone phosphate disodium | Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium is an orally active Glucocorticoid receptor agonist [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Dexamethasone 21-phosphate disodium. CAS No. 2392-39-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-B1829A. | |
| Dexamethasone phosphate (disodium) (Standard) | Dexamethasone phosphate (disodium) (Standard) is the analytical standard of Dexamethasone phosphate (disodium). This product is intended for research and analytical applications. Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium is an orally active Glucocorticoid receptor agonist [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2392-39-4. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1829AR. | |
| Dexamethasone (Standard) | Dexamethasone (Standard) is the analytical standard of Dexamethasone. This product is intended for research and analytical applications. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Hexadecadrol(Standard); Prednisolone F (Standard). CAS No. 50-02-2. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-14648R. | |
| Dexamethasone (Water Soluble) | Dexamethasone (Hexadecadrol) Water Soluble is a water-soluble form of Dexamethasone (HY-14648). Dexamethasone is a glucocorticoid receptor agonist, apoptosis inducer, and a common disease inducer in experimental animals. It can be used to construct models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has the potential to be used in COVID-19 research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Dexamethasone cyclodextrin complex. CAS No. 50-02-2. Pack Sizes: 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-14648C. | |
| Diflorasone | Diflorasone act as a corticosteroid hormone receptor agonist with anti-inflammatory and immunosuppressive properties. Diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorticoid receptor (GR) in the cytoplasm. Diflorasone is used for the research of skin diseases such as eczema or psoriasis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2557-49-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0158. | |
| Flumethasone pivalate | Flumethasone pivalate is a topical glucocorticoid receptor agonist with anti-inflammatory, antipruritic and vasoconstrictive properties. Uses: Anti-inflammatory drug. Synonyms: Locorten; Flumetasone pivalate; Lorinden; Locacorten; [2-[(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 2,2-dimethylpropanoate. Grades: 99%. CAS No. 2002-29-1. Molecular formula: C27H36F2O6. Mole weight: 494.57. | |
| Fluocinolone (Acetonide) | Fluocinolone is a glucocorticoid glucocorticoid receptor agonist. Fluocinolone is effective in preventing both lipid accumulation and inflammation. Fluocinolone can promote the proliferation of DPCs and has the potential role in repairing injured pulp tissues. Fluocinolone can be used to study the prevention of chemotherapy-induced peripheral neuropathy caused by Paclitaxel (HY-B0015) [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 67-73-2. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-B0415. | |
| Fluorometholone | Fluorometholone, a synthetic glucocorticoid, is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic properties. Fluorometholone can be used for the research of dry eye [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 426-13-1. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-B1893. | |
| Fluticasone (propionate) | Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity ( K D ) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 80474-14-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-B0154. | |
| Fosdagrocorat | Fosdagrocorat (PF-04171327) is a dissociated glucocorticoid receptor agonist. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-04171327. CAS No. 1044535-58-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16722. | |
| GSK 9027 | GSK 9027 is a glucocorticoid receptor agonist (pIC50 = 8) inhibiting production of the proinflammatory mediator IL-6 in vivo. GSK 9027 is used for the treatment of acute and chronic inflammatory conditions. Synonyms: GSK 9027; GSK9027; GSK-9027; N-[4-[1- (4-Fluorophenyl) -1H-indazol-5-yl-3- (trifluoromethyl) phenyl]benzenesulfonamide. Grades: ≥98% by HPLC. CAS No. 1229096-88-1. Molecular formula: C27H19F4N3O2S. Mole weight: 525.52. | |
| GW-870086 | GW-870086 is a glucocorticoid receptor agonist with a pIC50 of 10.1 in A549 cells expressing NF-κB. It can be used as an anti-inflammatory agent. Synonyms: GW-870086; GW-870086X; 870086; GW870086; GW870086X; GW 870086; GW 870086X. CAS No. 827319-43-7. Molecular formula: C31H39F2NO6. Mole weight: 559.651. | |
| Mapracorat | Mapracorat is a novel non-steroidal selective glucocorticoid receptor agonist. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ZK-245186; BOL-303242X. CAS No. 887375-26-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-14864. | |
| Mometasone furoate | Mometasone furoate (Sch32088) is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic activity. Mometasone furoate acts as a corticosteroid agent and used for topical applications in chronic skin eczema and airway inflammation management of asthma in vivo [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Sch32088. CAS No. 83919-23-7. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13693. | |
| Mometasone furoate (Standard) | Mometasone furoate (Standard) is the analytical standard of Mometasone furoate. This product is intended for research and analytical applications. Mometasone furoate (Sch32088) is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic activity. Mometasone furoate acts as a corticosteroid agent and used for topical applications in chronic skin eczema and airway inflammation management of asthma in vivo [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Sch32088 (Standard). CAS No. 83919-23-7. Pack Sizes: 10 mg; 25 mg; 50 mg. Product ID: HY-13693R. | |
| Nestoron | Nestorone is a steroidal progestin of the 19-norprogesterone group which is used as a hormonal contraceptive in several South American countries. It is a potent progesterone receptor agonist with no androgenic, estrogenic, or glucocorticoid-like activities. It has been used as a female contraceptive and may be useful as a male contraceptive too recently. It does not bind to the estrogen receptor either, but it has some affinity for the glucocorticoid receptor. It appears to act as an agonist, but it does not appear to produce any glucocorticoid side effects unless used at high doses. It has been shown to have neurogenic and neuroprotective activity. It holds back proinflammatory mediators and neuropathology in the wobbler mouse model of motoneuron degeneration. It protected against hippocampus abnormalities and improved functional outcomes of EAE mice, which suggests its potential value. It lacks affinity for the androgen receptor, thus does not produce any androgenic or anabolic effects. Uses: Nestorone is used as a hormonal contraceptive in several south american countries. it has been used as a female contraceptive and may be useful as a male contraceptive too recently. it lacks affinity for the androgen receptor, thus does not produce any androgenic or anabolic effects. Synonyms: ST-1435; ST1435; ST1435; Elcometrine; Nestorone; segesterone acetate; 17-Hydroxy-16-methylene-19-norpregn-4-ene-3,20-dione acetate; Elcometrine; 16-Methylene-17-hydroxy-19-norpregn-4-ene-3,20-dione acetate; Segesterone acetate; [(8R,9S,10R,13S,14S,17R)-17-acetyl-13-methyl-16-methylidene-3-oxo-2,6,7,8,9,10,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate. Grades: 95%. CAS No. 7759-35-5. Molecular formula: C23H30O4. Mole weight: 370.48. | |
| PF-04171327 | PF-04171327 is a dissociated agonist of the glucocorticoid receptor (DAGR), which is a selective high-affinity partial agonist of the GR. It has potent anti-inflammatory activity at exposures which provide less undesirable effects on bone and glucose metabolism. It is used to the treatment of rheumatoid arthritis. It was developed by Pfizer and was terminated in clinic phase 2. Uses: Pf-04171327 has potent anti-inflammatory activity. it is used to the treatment of rheumatoid arthritis. Synonyms: PF-04171327; PF04171327; PF 04171327; PF-4171327; PF4171327; PF 4171327; Fosdagrocorat;(2R,4aS,10aR)-4a-benzyl-7-((2-methylpyridin-3-yl)carbamoyl)-2-(trifluoromethyl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl dihydrogen phosphate. Grades: >98 %. CAS No. 1044535-58-1. Molecular formula: C29H30F3N2O5P. Mole weight: 574.53. | |
| Prednicarbate | Prednicarbate is a glucocorticoid receptor agonist. It is a synthetic non-halogenated double-ester derivative of the corticosteroid prednisolone with anti-inflammatory, antipruritic and vasoconstrictive properties. Uses: Anti-inflammatory agent. Synonyms: Prednicarbate; Hoe 777; Hoe-777; Dermatop E emollient; UNII-V901LV1K7D; prednisolone-17-ethylcarbonate-21-propionate; Batmen; Dermatop; HOE 777; HOE-777; Peitel; (11β)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-21-(1-oxopropoxy)pregna-1,4-diene-3,20-dione; Dermatop; EsCort; HOE 777; Prednisolone 17-(Ethyl Carbonate) 21-Propionate; Prednitop; Regenit; S 77-0777;[2-[(8S,9S,10R,11S,13S,14S,17R)-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] propanoate. Grades: 98%. CAS No. 73771-04-7. Molecular formula: C27H36O8. Mole weight: 488.57. | |
| Z-Guggulsterone | Z-Guggulsterone is a broad spectrum steroid receptor ligand that acts as a mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki = 37, 224 and 252 nM, respectively) and weak androgen receptor agonist (Ki = 315 nM). Z-Guggulsterone is also a selective antagonist of farnesoid X receptor (FXR) exhibiting antilipidemic, antiseptic, antirheumatic and anti-inflammatory activity in vivo. Synonyms: (Z)-Pregna-4,17(20)-diene-3,16-dione. Grades: ≥98% by HPLC. CAS No. 39025-23-5. Molecular formula: C21H28O2. Mole weight: 312.45. | |
| (+)-ZK 216348 | (+)-ZK 216348 is a selective nonsteroidal glucocorticoid receptor (GR) agonist for the treatment of experimental colitis (IC50 values of 20, 20, and 80 nM for GR, Progesterone (PR) and Mineralocorticoid (MR) receptors, respectively). (+)-ZK 216348 exhibits antiinflammatory activity for both systemic and topical application, and shows no negative effects on intestinal epithelial migration or proliferation. Synonyms: ZK216348; ZK 216348; ZK-216348; 4-(2,3-dihydro-1-benzofuran-7-yl)-2-hydroxy-4-methyl-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)-2-(trifluoromethyl)pentanamide. Grades: 99%. CAS No. 669073-68-1. Molecular formula: C24H23F3N2O5. Mole weight: 476.45. | |
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