Glucokinase Suppliers USA
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Product | Description | |
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1,3-Dimethoxy-2-propanol Quick inquiry Where to buy Suppliers range | 1,3-Dimethoxy-2-propanol is a possbile antiknock additive for gasoline and diesel fuel. It is also used to prepare heteroarylcarbamoyl Benzene derivatives as glucokinase activators. Group: Biochemicals. Grades: Highly Purified. CAS No. 623-69-8. Pack Sizes: 250mg, 500mg. Molecular Formula: C5H12O3, Molecular Weight: 120.15. US Biological Life Sciences. | Worldwide |
1,3-Dimethoxy-2-propanol-d5 Quick inquiry Where to buy Suppliers range | 1,3-Dimethoxy-2-propanol-d5 is labelled 1,3-Dimethoxy-2-propanol (D471325) which is a possbile antiknock additive for gasoline and diesel fuel. It is also used to prepare heteroarylcarbamoyl Benzene derivatives as glucokinase activators. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C5H7D5O3, Molecular Weight: 125.18. US Biological Life Sciences. | Worldwide |
1-Fluoro-cyclopentanemethanol Quick inquiry Where to buy Suppliers range | 1-Fluoro-cyclopentanemethanol is used to preapre glucokinase activators to treat metabolic disorders. Group: Biochemicals. Grades: Highly Purified. CAS No. 892878-43-2. Pack Sizes: 250mg, 2.5g. Molecular Formula: C6H11FO, Molecular Weight: 118.15. US Biological Life Sciences. | Worldwide |
2-Fluorophenyl Methyl Sulfone Quick inquiry Where to buy Suppliers range | 2-Fluorophenyl Methyl Sulfone is used as a reagent in the synthesis of thiazolyl benzamides as novel allosteric glucokinase activators. Group: Biochemicals. Grades: Highly Purified. CAS No. 654-47-7. Pack Sizes: 1g, 2.5g. Molecular Formula: C7H7FO2S. US Biological Life Sciences. | Worldwide |
2-Oxocyclopentane carboxylic Acid Quick inquiry Where to buy Suppliers range | 2-Oxocyclopentane carboxylic Acid is a reactant that has been used in the synthesis of Piragliatin, a glucokinase activator. Group: Biochemicals. Grades: Highly Purified. CAS No. 50882-16-1. Pack Sizes: 1g, 10g. Molecular Formula: C6H8O3, Molecular Weight: 128.13. US Biological Life Sciences. | Worldwide |
3-Deoxy-3-fluoro-D-glucitol Quick inquiry Where to buy Suppliers range | 3-Deoxy-3-fluoro-D-glucitol, also known as FDG, is an immensely powerful antidiabetic drug that exhibits significant efficacy in managing type 2 diabetes mellitus. This remarkable medication operates through its ability to impede the glucokinase enzyme, culminating in a notable decline in blood glucose concentrations. Additionally, its intricate mechanism entails the augmentation of insulin sensitivity and facilitation of glucose utilization within the physiological framework. CAS No. 34339-82-7. Molecular formula: C6H13FO5. Mole weight: 184.16. | |
4-Toluoyl 2,3-di-O-benzoyl-4,6-O-benzylidene-b-D-thioglucopyranoside Quick inquiry Where to buy Suppliers range | 4-Toluoyl 2,3-di-O-benzoyl-4,6-O-benzylidene-b-D-thioglucopyranoside, an indispensable compound with extensive applications in the field of biomedicine, holds immense scientific value. Its remarkable functionality as a glucokinase enzyme activator offers promising prospects for the treatment of diabetes. Moreover, the inhibitory effects demonstrated against pancreatic α-amylase and α-glucosidase make it a compelling contender for the advancement of anti-diabetic pharmaceuticals. Molecular formula: C35H30O8S. Mole weight: 610.68. | |
AM-2394 Quick inquiry Where to buy Suppliers range | AM-2394 is a selective Glucokinase agonist (GKA), It activates GK with an EC50 value of 60 nM. AM-2394 increases the affinity of GK for glucose by approximately 10-fold. It shows moderate clearance and good oral bioavailability in animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. Uses: Diabetes. Synonyms: AM-2394; AM 2394; AM2394; 1-(6'-(2-hydroxy-2-methylpropoxy)-4-((5-methylpyridin-3-yl)oxy)-[3,3'-bipyridin]-6-yl)-3-methylurea. Grades: 98%. CAS No. 1442684-77-6. Molecular formula: C22H25N5O4. Mole weight: 423.47. | |
AM-9514 Quick inquiry Where to buy Suppliers range | AM-9514 is a glucokinase (GK) activator. It shows a favorable combination of in vitro potency, enzyme kinetic properties, acceptable pharmacokinetic profiles in preclinical species, and robust efficacy in a rodent PD model. Glucokinase is very important in regulating glucose homeostasis. AM-9514 may become a drug candidate for the treatment of type 2 diabetes. Uses: Type 2 diabetes. Synonyms: AM-9514; AM9514; AM 9514; 1-(3-((1-ethyl-1H-pyrazol-5-yl)oxy)-5-(((1r,3s)-3-hydroxy-3-methylcyclobutyl)methyl)pyridin-2-yl)-3-methylurea. Grades: 98%. CAS No. 1442677-18-0. Molecular formula: C18H25N5O3. Mole weight: 359.43. | |
AMG-3969 Quick inquiry Where to buy Suppliers range | AMG-3969 is a potent and selective disruptor of glucokinase-glucokinase regulatory protein interaction (GK-GKRP). AMG-3969 can modulate the blood glucose levels in rodent models of diabetes. Synonyms: 2-[4-[(2S)-4-(6-aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol. Grades: 98% by HPLC. CAS No. 1361224-53-4. Molecular formula: C21H20F6N4O3S. Mole weight: 522.466. | |
ARRY 403 Quick inquiry Where to buy Suppliers range | ARRY-403 is an orally available Glucokinase stimulants originated by Array BioPharma. ARRY-403 activates human glucokinase in vitro with EC50 of 79 nM at 5 mM glucose and Vmax = 134% compared to the no activator control. It exhibits good in vitro drug-like properties and selectivity against broad panels of receptors and enzymes. But,treatment for Type 2 diabetes mellitus was discontinued. Uses: Type 2 diabetes mellitus. Synonyms: ARRY-403; ARRY-403; ARRY-403; AMG-151; AMG 151; AMG151;(1S)-1-[5-({3-[(2-methylpyridin-3-yl)oxy]-5-(pyridin-2-ylsulfanyl)pyridin-2-yl}amino)-1,2,4-thiadiazol-3-yl]ethane-1,2-diol. Grades: 98%. CAS No. 1304015-76-6. Molecular formula: C20H18N6O3S2. Mole weight: 454.53. | |
BMS-212 Quick inquiry Where to buy Suppliers range | BMS-212 is a potent and selective stimulator of glucokinase (GK) (EC50 = 35 nM) that is promisingly used as an antidiabetic. BMS-212 has a preference for GK in liver over GK in pancreas, of which the activation may lead to non-glucose-dependent insulin secretion. Half-life of BMS-212 is 4.2h, and oral bioavailability is 15%. Uses: Potential antidiabetic. Synonyms: BMS212; BMS 212. CAS No. 2173153-38-1. Molecular formula: C25H30N3O9PS2. Mole weight: 611.62. | |
D-Allose-6-phosphate disodium salt hydrate Quick inquiry Where to buy Suppliers range | D-Allose-6-phosphate disodium salt hydrate, a dynamic biomedical substance, is renowned for its efficaciousness in combating specific ailments. Serving as a formidable hindrance to glucokinase, a multifaceted enzyme entangled in numerous metabolic maladies such as type 2 diabetes, this compound boasts an unrivaled chemical configuration that intricately modulates glucose metabolism. Synonyms: 6-O-[Hydroxy(oxo)phosphaniumyl]-D-allose; D-Allose,6-(dihydrogen phosphate); hydroxy-oxo-[(2R,3R,4R,5R)-2,3,4,5-tetrahydroxy-6-oxohexoxy]phosphanium; DTXSID90849400; [(1R,4S)-4-HYDROXY-2-CYCLOPENTEN-1-YL]CARBAMICACID,1,1-DIMETHYLETHYLESTER. CAS No. 82259-50-5. Molecular formula: C6H11O9PNa2. Mole weight: 304.10. | |
GKA 50 Quick inquiry Where to buy Suppliers range | GKA 50 is a potent glucokinase activator (EC50 = 33 nM). It causes a decrease in plasma glucose levels in diabetic rats and an increase of insulin release from mouse islets of Langerhans. GKA 50 was shown to promote proliferation and prevent apoptosis in rat pancreatic insulinoma-1 beta cell. Synonyms: GKA 50; GKA50; GKA-50; 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino-3-pyridinecarboxylic acid. Grades: ≥98% by HPLC. CAS No. 851884-87-2. Molecular formula: C26H28N2O6. Mole weight: 464.51. | |
Glucolipsin A Quick inquiry Where to buy Suppliers range | It is produced by the strain of Streptomyces purpurogeniscleroticus WC 71634, Nocardia vaccinii WC 65712. It is a glucokinase activator. It can reactivate the glucokinase inhibited by FAC with RC50 of 5.4 μmol/L. CAS No. 222613-92-5. Molecular formula: C50H92O14. Mole weight: 917.25. | |
Glucolipsin B Quick inquiry Where to buy Suppliers range | It is produced by the strain of Streptomyces purpurogeniscleroticus WC 71634, Nocardia vaccinii WC 65712. It is a glucokinase activator. It can reactivate the glucokinase inhibited by FAC with RC50 of 4.6 μmol/L. CAS No. 222613-93-6. Molecular formula: C49H90O14. Mole weight: 903.23. | |
LBX192 Quick inquiry Where to buy Suppliers range | LBX192 is a Liver Targeted Glucokinase Activator. It can activate the GK enzyme in vitro at low nM concentrations and reduce glucose levels during an oral glucose tolerance test in normal as well as diabetic mice. Synonyms: LBX192; LBX 192; LBX-192; NVP-LBX192; NVP-LBX-192; NVP-LBX 192; (R)-3-cyclopentyl-N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)-2-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)propanamide. Grades: 98%. CAS No. 866772-52-3. Molecular formula: C26H33N5O4S2. Mole weight: 543.70. | |
LY2608204 Quick inquiry Where to buy Suppliers range | LY2608204 activates glucokinase (GK) with EC50 of 42 nM at 10 mM glucose with a concentration dependent manner at lower glucose concentrations. Uses: Enzyme activators. Synonyms: LY-2608204; LY 2608204; LY2608204. Grades: >98%. CAS No. 1234703-40-2. Molecular formula: C28H37N3O3S3. Mole weight: 559.81. | |
Mannoheptulose Quick inquiry Where to buy Suppliers range | Mannoheptulose is a biochemical compound widely used in the biomedicine industry. Derived from mannose, it possesses potential therapeutic applications in treating diabetes and obesity. Mannoheptulose works by inhibiting the enzyme glucokinase, playing a crucial role in cellular glucose metabolism. Its efficacy and safety profiles make it a promising candidate for further research and development in managing metabolic disorders. CAS No. 654-29-5. Molecular formula: C7H14O7. Mole weight: 210.182. | |
methyl 3-(benzyloxy)-5-hydroxybenzoate Quick inquiry Where to buy Suppliers range | An intermediate in the synthesis of the glucokinase activator GKA 50. Synonyms: 3-Benzyloxy-5-hydroxy-benzoic Acid Methyl Ester. CAS No. 54915-31-0. Molecular formula: C15H14O4. Mole weight: 258.27. | |
MK-0941 mesylate Quick inquiry Where to buy Suppliers range | MK-0941 is a glucokinase activator used for the treatment of type II diabetes. It increases the risk of hypoglycemia and elevations in triglycerides and blood pressure. Synonyms: MK-0941; MK 0941; MK0941; 3-(6-ethylsulfonylpyridin-3-yl)oxy-5-[(2S)-1-hydroxypropan-2-yl]oxy-N-(1-methylpyrazol-3-yl)benzamide mesylate. Grades: ≥98%. CAS No. 1137916-97-2. Molecular formula: C21H24N4O6S·CH3SO3H. Mole weight: 556.61. | |
N-Glycinyl-1-deoxy-D-glucitol Quick inquiry Where to buy Suppliers range | N-Glycinyl-1-deoxy-D-glucitol is also known as N-GDN, specifically designed for studying diabetes. Its exceptional glucokinase activation properties not only magnify insulin secretion but also augment glucose utilization. Synonyms: N-Glucosylglycine. Molecular formula: C8H17NO7. Mole weight: 239.22. | |
PF-04937319 Quick inquiry Where to buy Suppliers range | This active molecular is a glucokinase activator originated by Pfizer and EC50 value is 174 nM. PF-04937319 can improve glycemic control in adults with type 2 diabetes when applicated in conjunction with metformin and it can also maintain lower-glucose levels without it resulting in hypoglycemia. However,clinical trials were discontinued for Type 2 diabetes mellitus in 2016. Uses: Type 2 diabetes mellitus. Synonyms: PF-04937319; PF04937319; PF 04937319; PF-4937319; PF 4937319; PF4937319; N,N-dimethyl-5-((2-methyl-6-((5-methylpyrazin-2-yl)carbamoyl)benzofuran-4-yl)oxy)pyrimidine-2-carboxamide. Grades: 98%. CAS No. 1245603-92-2. Molecular formula: C22H20N6O4. Mole weight: 432.44. | |
PF-04991532 Quick inquiry Where to buy Suppliers range | This active molecular is a hepatoselective glucokinase activator that reduces MDG (mean daily glucose), FPG (fasting plasma glucose) and glucose excursion in humans. PF-04991532 may offer glycemic control without inducing hepatic steatosis. PF-04991532 was developed by Pfizer but was discontinued in Phase-II for Type-2 diabetes mellitus in USA in 2012. Uses: Type 2 diabetes mellitus. Synonyms: PF-04991532; PF 04991532; PF04991532; PF-4991532; PF4991532; PF 4991532; UNII-AJ212MS2O2; CHEMBL2165620; AJ212MS2O2; SCHEMBL1711504; BDBM50394681; 6-[[(2S)-3-cyclopentyl-2-[4-(trifluoromethyl)imidazol-1-yl]propanoyl]amino]pyridine-3-carboxylic acid. Grades: 98%. CAS No. 1215197-37-7. Molecular formula: C18H19F3N4O3. Mole weight: 396.37. | |
RO 28-0450 Quick inquiry Where to buy Suppliers range | RO 28-0450 is a glucokinase GK agonist. Synonyms: RO 28-1674; RO-28-1674; RO 28 1674; RO-28 1674; RO281674; 3-Cyclopentyl-2-(4-methanesulfonyl-phenyl)-N-thiazol-2-yl-propionamide. Grades: 98%. CAS No. 300352-96-9. Molecular formula: C18H22N2O3S2. Mole weight: 378.51. | |
RO 28-1674 Quick inquiry Where to buy Suppliers range | RO 28-1674 is a glucokinase GK agonist. Synonyms: RO 28-1674; RO 28 1674; RO-28-1674; RO-28 1674; RO281674; (S)-3-cyclopentyl-2-(4-(methylsulfonyl)phenyl)-N-(thiazol-2-yl)propanamide. Grades: 99%. CAS No. 599164-57-5. Molecular formula: C18H22N2O3S2. Mole weight: 378.51. | |
Ro 28-1675 Quick inquiry Where to buy Suppliers range | A cell-permeable thiazolyl-propanamide compound that acts as a glucokinase (GK) activator by increasing Vmax and decreasing [S]1/2 of GK-catalyzed reaction as well as freeing GK from the inhibitory action of GK regulatory protein (GKRP), resulting in increased. Induces GK nuclear-to-cytosol translocation in primary rat hepatocytes and reduces glucose concentration for insulin secretion stimulation from isolated rat pancreatic islets (threshold [glucose] = 3 mM vs 6 mM with or without 3 μM Ro-28-1675). Exhibits in vivo glucose-lowering and insulin-releasing activity in non-diabetic C57BL/6 mice and Wistar rats and is efficacious in several murine and rodent type II diabetes mellitus (T2DM) models (10 to 50 mg/kg via p.o.). Does not affect hexokinase I or II activity. Synonyms: RO28-1675; RO-28-1675; RO 28-1675; RO028-1675; RO-028-1675; RO 028-1675; RO281675; RO 281675; RO-281675; Ro 0281675; Ro-0281675; Ro0281675. Grades: >98%. CAS No. 300353-13-3. Molecular formula: C18H22N2O3S2. Mole weight: 378.51. | |
RO4389620 Quick inquiry Where to buy Suppliers range | RO4389620 is a glucokinase activator. It greatly enhances glucose-induced pancreatic islet respiration and insulin release. It has an acute glucose-lowering action in patients with mild type 2 diabetes by a generalized enhancement of β-cell function and fasting restricted changes in glucose turnover. It was developed by Roche and was in clinic phase 2 trials, but now it is terminated. Uses: Ro4389620 has an acute glucose-lowering action in patients with mild type 2 diabetes. Synonyms: RO-4389620; RO 4389620; Piragliatin; (R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-((R)-3-oxocyclopentyl)-N-(pyrazin-2-yl)propanamide. Grades: 98%. CAS No. 625114-41-2. Molecular formula: C19H20ClN3O4S. Mole weight: 421.89. |