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| Product | Description | |
|---|---|---|
| Glucosylceramide | Glucosylceramide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Ceramide,1-O-β-D-glucopyranosyl-;GangliosideGL1a;Gulcocerebroside;SOYBEAN GLUCOCEREBROSIDES;GLUCOSYLCERAMIDE;Glucosylceramide (d18:1/12:0);N-((2S,3R,E)-3-hydroxy-1-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)octadec-4-en-2-yl)dodecanamide;Glucosylceramide (d18:1/16:0). Product Category: Heterocyclic Organic Compound. CAS No. 85305-87-9. Molecular formula: C9H18N2O7. Mole weight: 266.25. Product ID: ACM85305879. Alfa Chemistry ISO 9001:2015 Certified. |  |
| glucosylceramide β-1,4-galactosyltransferase | Involved in the synthesis of several different major classes of glycosphingolipids. Group: Enzymes. Synonyms: lactosylceramide synthase; uridine diphosphate-galactose:glucosyl ceramide β 1-4 galactosyltransferase; UDP-Gal:glucosylceramide β1?4galactosyltransferase; GalT-2 (misleading); UDP-galactose:β-D-glucosyl-(1<->1)-ceramide β-1,4-galactosyltransferase. Enzyme Commission Number: EC 2.4.1.274. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2506; glucosylceramide β-1,4-galactosyltransferase; EC 2.4.1.274; lactosylceramide synthase; uridine diphosphate-galactose:glucosyl ceramide β 1-4 galactosyltransferase; UDP-Gal:glucosylceramide β1?4galactosyltransferase; GalT-2 (misleading); UDP-galactose:β-D-glucosyl-(1<->1)-ceramide β-1,4-galactosyltransferase. Cat No: EXWM-2506. |  |
| Glucosylceramide (Soy) | Glucosylceramide is synthesised enzymatically, by the glucosylceramide synthase-catalysed with the addition of a glucose residue to ceramide. They are present in neuronal and non-neuronal mammalian tissues and are found at low quantities in a large number of plant species, where they comprise 5-30% of total lipids in the plant plasma membrane, and in fungi. Synonyms: Cerebroside (Soy); GlcCer(d18:2/16:0). Grades: >99%. CAS No. 497155-61-0. Molecular formula: C40H75NO9. Mole weight: 714.03. |  |
| C2 Adamantanyl Glucosylceramide (d18:1/2:0) | C2 Adamantanyl glucosylceramide (AdaGluCer) is a bioactive sphingolipid. It increases levels of glycosphingolipids in Vero cells at low concentrations (≤20 μM) but decreases them at high concentrations (≥40 μM). Pretreatment of microsomes with AdaGluCer increases production of adamantanyl lactosylceramide (AdaLacCer) and reduces synthesis of LacCer from exogenous GlcCer. AdaGluCer inhibits glucocerebrosidase activity in vitro in a pH-dependent manner. Synonyms: N-(1-Adamantaneacetyl) Glucosylceramide; Adamantanyl GluCer(d18:1/2:0); Adamantanyl Glucosylceramide (d18:1/2:0); AdaGluCer(d18:1/2:0). Grades: ≥98%. Molecular formula: C36H61NO8. Mole weight: 635.87. | |
| (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase | This enzyme catalyses the formation of the gangliosides (i.e. sialic-acid-containing glycosphingolipids) GM2, GD2 and SM2 from GM3, GD3 and SM3, respectively. Asialo-GM3 and lactosylceramide are also substrates, but glycoproteins and oligosaccharides are not substrates. Group: Enzymes. Synonyms: uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase; ganglioside GM2 synthase; ganglioside GM3 acetylgalactosaminyltransferase; GM2 synthase; UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide acetylgalactosaminyltransferase; UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-α-neuraminyl)-(2?3)-O-β-D-galactopyranosyl-(1?4)-β-D-glucopyranosyl]-ceramide 1,4-β-N-acetyl-D-galactosaminyltransferase acetylgalactosa. Enzyme Commission Number: EC 2.4.1.92. CAS No. 67338-98-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2632; (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase; EC 2.4.1.92; 67338-98-1; uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase; ganglioside GM2 synthase; ganglioside GM3 acetylgalactosaminyltransferase; GM2 synthase; UDP acetylgalactosamine-(N-acetylneuraminyl)-D-gal | |
| 1,2-Dideoxy-2-fluoronojirimycin | 1,2-Dideoxy-2-fluoronojirimycin is a potent biological inhibitor employed in the research of Gaucher Disease. It can inhibit glucosylceramide synthase, responsible for the disease's metabolic dysfunction, thus helping to manage its symptoms effectively. CAS No. 134336-23-5. Molecular formula: C6H12NO3F. Mole weight: 165.16. | |
| 1,6-Dideoxy-L-altronojirimycin | 1,6-Dideoxy-L-altronojirimycin is a pharmaceutical compound used for the treatment of Gaucher disease. It functions as an inhibitor of glucosylceramide synthase, which causes an accumulation of glucocerebrosides in cells affected by the disease. Synonyms: 1,5,6-Trideoxy-1,5-imino-D-altritol. CAS No. 168252-99-1. Molecular formula: C6H13NO3. Mole weight: 147.17. | |
| 2,3,4,6-Tetra-O-benzyl-1-L-ido-miglustat | 2,3,4,6-Tetra-O-benzyl-1-L-ido-miglustat is a useful reagent in preparation of pharmaceutically active aza-sugar piperidine derivatives as inhibitors of galactosidase and glucosylceramide synthase. Group: Biochemicals. Grades: Highly Purified. CAS No. 441061-29-6. Pack Sizes: 10mg, 25mg. Molecular Formula: C38H45NO4, Molecular Weight: 579.77. US Biological Life Sciences. |  Worldwide |
| β-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide β-1,3-acetylglucosaminyltransferase | Requires Mn2+. Group: Enzymes. Synonyms: uridine diphosphoacetylglucosamine-acetyllactosaminide β1?3-acetylglucosaminyltransferase; poly-N-acetyllactosamine extension enzyme; UDP-N-acetyl-D-glucosamine:β-D-galactosyl-1,4-N-acetyl-β-D-glucosaminyl-1,3-β-D-galactosyl-1,4-β-D-glucosylceramide β-1,3-acetylglucosaminyltransferase. Enzyme Commission Number: EC 2.4.1.163. CAS No. 85638-39-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2388; β-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide β-1,3-acetylglucosaminyltransferase; EC 2.4.1.163; 85638-39-7; uridine diphosphoacetylglucosamine-acetyllactosaminide β1?3-acetylglucosaminyltransferase; poly-N-acetyllactosamine extension enzyme; UDP-N-acetyl-D-glucosamine:β-D-galactosyl-1,4-N-acetyl-β-D-glucosaminyl-1,3-β-D-galactosyl-1,4-β-D-glucosylceramide β-1,3-acetylglucosaminyltransferase. Cat No: EXWM-2388. | |
| C2 Adamantanyl Galactosylceramide (d18:1/2:0) | C2 Adamantanyl Galactosylceramide (d18:1/2:0) is a bioactive sphingolipid. It reduces globotriaosylceramide 3 synthesis from exogenous lactosylceramide in microsomes. AdaGalCer stimulates recombinant glucocerebrosidase activity in a pH-dependent manner. It activates glucocerebrosidase to decrease glucosylceramide accumulation in fibroblasts and lymphoblasts isolated from patients with Gaucher and Fabry disease, respectively. Synonyms: [(2S,3R,4E)-2-[(1-Adamantyl)acetylamino]-3-hydroxy-4-octadecenyl]beta-D-galactopyranoside; N-(1-Adamantaneacetyl)-galactosylceramide; Adamantanyl Galactosyl(β) Ceramide; AdaGalCer(d18:1/2:0). Grades: ≥98%. CAS No. 574738-16-2. Molecular formula: C36H63NO8. Mole weight: 637.89. | |
| C6 NBD Ceramide | C6 NBD Ceramide is a Golgi apparatus fluorescent probe with cell membrane permeability. C6 NBD Ceramide can be used for fast and convenient green fluorescent labeling of Golgi in living and fixed cells, and can be used to observe changes in Golgi morphology in living cells (Ex=466 nm, Em=536 nm). C6-NBD-ceramide is metabolized to fluorescent sphingomyelin and glucosylceramide, can be used for the study of sphingolipid transport and metabolic mechanism [1] [2] [3]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Nbd-ceramide. CAS No. 94885-02-6. Pack Sizes: 1 mg. Product ID: HY-W356116. |  |
| ceramide glucosyltransferase | Sphingosine and dihydrosphingosine can also act as acceptors; CDP-glucose can act as donor. Group: Enzymes. Synonyms: UDP-glucose:ceramide glucosyltransferase; ceramide:UDP-Glc glucosyltransferase; uridine diphosphoglucose-ceramide glucosyltransferase; ceramide:UDP-glucose glucosyltransferase; glucosylceramide synthase; UDP-glucose:N-acylsphingosine D-glucosyltransferase. Enzyme Commission Number: EC 2.4.1.80. CAS No. 37237-44-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2621; ceramide glucosyltransferase; EC 2.4.1.80; 37237-44-8; UDP-glucose:ceramide glucosyltransferase; ceramide:UDP-Glc glucosyltransferase; uridine diphosphoglucose-ceramide glucosyltransferase; ceramide:UDP-glucose glucosyltransferase; glucosylceramide synthase; UDP-glucose:N-acylsphingosine D-glucosyltransferase. Cat No: EXWM-2621. | |
| Cholesterol β-D-Glucoside | Cholesterol β-D-glucoside is a derivative of cholesterol that contains β-D-glucose. It is formed from cholesterol and glucosylceramide by β-glucosidase 1. It is a lipid mediator in heat stress responses in animals, showing anti-ulcer effect. It activates heat shock transcription factor 1 (Hsf1) in response to heat shock, which increases the expression of heat shock protein 70 (Hsp70) in TIG-3 human fetal lung fibroblasts when used at a concentration of 10 μM. Synonyms: β-ChlGlc; Cholesteryl Glucoside; GluChol; Glucosyl Cholesterol; β-D-glucosyl cholesterol. Grades: ≥95%. CAS No. 7073-61-2. Molecular formula: C33H56O6. Mole weight: 548.79. | |
| DL-erythro-PPMP hydrochloride | DL-erythro-PPMP is an inactive stereoisomer of DL-threo-PPMP. It has no effect on glucosylceramide synthetase activity and is used as a negative control for DL-threo-PPMP, D-threo-PPMP, and L-threo-PPMP inhibitory effect. Synonyms: DL-erythro-1-phenyl-2-Palmitoylamino-3-morpholino-1-propanol. Grades: ≥98%. Molecular formula: C29H50N2O3·HCl. Mole weight: 511.18. | |
| DL-threo-PDMP hydrochloride | DL-threo-PDMP hydrochloride is the hydrochloride form of DL-threo-PDMP that is a competitive glucosylceramide synthase ( GCS ) inhibitor. DL-threo-PDMP resensitizes refractory testicular germ cell tumors and epithelial ovarian cancer orthoxenografts to cisplatin in mice [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 80938-69-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-116392B. | |
| DL-threo-PDMP hydrochloride | DL-threo PDMP is a mixture of ceramide analogs that contains two of the four possible stereoisomers of PDMP: D-threo (1R,2R) and L-threo (1S,2S) PDMP. DL-threo-PDMP inhibits glucosylceramide synthase by 33 and 48% in MDCK cell homogenates when used at concentrations of 5 and 10 μM. It reduces the synthesis of glucosylceramide, increases cellular ceramide, and induces cell cycle arrest in vitro. Synonyms: DL-PDMP; D,l-Threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol HCl; SMR000326846. Grades: ≥98%. CAS No. 80938-69-8. Molecular formula: C23H38N2O3·HCl. Mole weight: 427. | |
| DL-threo-PPMP hydrochloride | DL-threo-PPMP is a ceramide analog that inhibits glucosylceramide synthase. It has been used to study the role of glucosylceramide synthase in cell growth, apoptosis, and autophagy. Synonyms: DL-threo-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol; DL-PPMP; BML3-D12; CTK8E7792. Grades: ≥98%. CAS No. 139974-41-7. Molecular formula: C29H50N2O3·HCl. Mole weight: 511.2. | |
| (+)-D-threo-PDMP hydrochloride | (+)-D-threo-PDMP is a ceramide analog and is one of the four possible stereoisomers of PDMP. (+)-D-threo-PDMP is an inhibitor of glucosylceramide synthase. Synonyms: d-threo-PDMP; 109836-82-0; 80938-69-8; (+)-D-threo-PDMP (hydrochloride); DL-threo-PDMP (hydrochloride); 139889-62-6; N-[(1R,2R)-1-hydroxy-3-morpholin-4-yl-1-phenylpropan-2-yl]decanamide; hydrochloride; N-[(1R,2R)-2-Hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-decanamide, monohydrochloride; SMR000326846; DL-threo-PDMP; (+/-)-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol hydrochloride; D-Threo-pdmp-HCl; MLS000859987; MLS002153295; BML3-D11; CHEMBL1255585; EX-A8002H; DTXSID401017468; D-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL; AKOS040755898; J-002336; D-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol*HCl; N-((1R,2R)-1-hydroxy-3-morpholino-1-phenylpropan-2-yl)decanamide hydrochloride; Decanamide,N-[(1R,2R)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-,hydrochloride(1:1),rel-. Grades: ≥98%. CAS No. 139889-62-6. Molecular formula: C23H38N2O3·HCl. Mole weight: 427.03. | |
| D-threo-PDMP hydrochloride | D-threo-PDMP hydrochloride is a glucosylceramide (GlcCer) synthase inhibitor that inhibits glucosylceramide (GlcCer) and lactosylceramide (LacCer) levels in B16 melanoma cells. D-threo-PDMP hydrochloride lacks reactivity to the other two surface antigens anti-melanoma monoclonal antibodies M562 and M622 and the major histocompatibility antigen anti-H-2KbDb monoclonal antibody, so it is specific for B16 melanoma sex [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 139889-62-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-116392F. | |
| D-threo-PPMP hydrochloride | D-threo-PPMP is a glucosylceramide (GlyCer) synthetase inhibitor, which is the active enantiomer and enzymatic inhibitory component of the racemic DL-threo-PPMP. In MDCK kidney epithelial cells, D-threo-PPMP induces a 70% reduction in cell growth in vitro at 20 μM and significantly inhibits DNA synthesis at 3 μM. Synonyms: D-threo-1-phenyl-2-Palmitoylamino-3-morpholino-1-propanol; [R-(R*,R*)]-N-[2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-hexadecanamide, monohydrochloride. Grades: ≥98%. CAS No. 139889-65-9. Molecular formula: C29H50N2O3·HCl. Mole weight: 511.2. | |
| Eliglustat | Eliglustat is a glucosylceramide synthase inhibitor indicated for the long-term treatment of type 1 Gaucher disease in patients who are CYP2D6 extensive metabolizers, intermediate metabolizers , or poor metabolizers in treatment-naive and treatment-experi. Uses: Inhibits glucosylceramide synthase(gcs). Synonyms: Genz-99067; Genz 99067; Genz99067;N-[(1R,2R)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-pyrrolidin-1-ylpropan-2-yl]octanamide. Grades: ≥98%. CAS No. 491833-29-5. Molecular formula: C23H36N2O4. Mole weight: 404.55. | |
| Eliglustat hemitartrate | Eliglustat hemitartrate is a specific inhibitor of glucosylceramide synthase. It is under development as an oral substrate reduction therapy for Gaucher disease type 1 (GD1). It was developed by Genzyme Corp and has been listed by the FDA August 2014. Synonyms: Genz-112638; Genz 112638; Genz112638; Eliglustat tartrate; Bis(N-((1R,2R)-2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(pyrrolidin-1- ylmethyl)ethyl)octanamide) (2R,3R)-2,3-dihydroxybutanedioate; Octanamide, N-((1R,2R)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1- pyrrolidinylmethyl)ethyl)-, (2R,3R)-2,3-dihydroxybutanedioate; N-[(1R,2R)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-pyrrolidin-1-ylpropan-2-yl]octanamide (2R,3R)-2,3-dihydroxybutanedioic acid. Grades: >98%. CAS No. 928659-70-5. Molecular formula: C50H78N4O14. Mole weight: 959.17. | |
| galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide β-1,6-N-acetylglucosaminyltransferase | Requires Mn2+. Group: Enzymes. Synonyms: uridine diphosphoacetylglucosamine-acetyllactosaminide β1?6-acetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-N-acetyl-β-D-glucosaminyl-1,3-β-D-galactosyl-1,4-β-D-glucosylceramide β-1,6-N-acetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:D-galactosyl-(1?4)-N-acetyl-β-D-glucosaminyl-(1?3)-β-D-galactosyl-(1?4)-β-D-glucosyl(1<->1)ceramide 6-β-N-acetylglucosaminyltransferase. Enzyme Commission Number: EC 2.4.1.164. CAS No. 85638-40-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2389; galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide β-1,6-N-acetylglucosaminyltransferase; EC 2.4.1.164; 85638-40-0; uridine diphosphoacetylglucosamine-acetyllactosaminide β1?6-acetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-N-acetyl-β-D-glucosaminyl-1,3-β-D-galactosyl-1,4-β-D-glucosylceramide β-1,6-N-acetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:D-galactosyl-(1?4)-N-acetyl-β-D-glucosaminyl-(1?3)-β-D-galactosyl-(1?4)-β-D-glucosyl(1<->1)ceramide 6-β-N-acetylglucosaminyltransferase. Cat No: EXWM-2389. | |
| Genz-123346 Free base | Genz-123346 is a glucosylceramide synthase inhibitor with potential anticancer activity. Exposure of cells to Genz-123346 and to other GCS inhibitors at non-toxic concentrations can enhance the killing of tumor cells by cytotoxic anti-cancer agents. Genz-123346 and a few other GCS inhibitors are substrates for multi-drug resistance efflux pumps such as P-gp (ABCB1, gP-170). In cell lines selected to over-express P-gp or which endogenously express P-gp, chemosensitization by Genz-123346 was primarily due to the effects on P-gp function. Synonyms: Genz-123346; Genz123346; Genz 123346. CAS No. 491833-30-8. Molecular formula: C24H38N2O4. Mole weight: 418.57. | |
| globoside α-N-acetylgalactosaminyltransferase | This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. Group: Enzymes. Synonyms: uridine diphosphoacetylgalactosamine-globoside α-acetylgalactosaminyltransferase; Forssman synthase; globoside acetylgalactosaminyltransferase; UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide α-N-acetyl-D-galactosaminyltransferase; UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-(1?3)-D-galactosyl-(1?4)-D-galactosyl-(1?4)-D-glucosyl-(1<->1)-ceramide α-N-ace. Enzyme Commission Number: EC 2.4.1.88. CAS No. 52037-97-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2628; globoside α-N-acetylgalactosaminyltransferase; EC 2.4.1.88; 52037-97-5; uridine diphosphoacetylgalactosamine-globoside α-acetylgalactosaminyltransferase; Forssman synthase; globoside acetylgalactosaminyltransferase; UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide α-N-acetyl-D-galactosaminyltransferase; UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-(1?3)-D-galactosyl-(1?4)-D-galactosyl-(1?4)-D-glucosyl-(1<->1)-ceramide α-N-acetyl-D-galactosaminyltransferase. Cat No: EXWM-2628. | |
| glucosaminyl galactosyl glucosyl ceramide β-galactosyltransferase | This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. Group: Enzymes. Synonyms: uridine diphosphogalactose-acetyl -glucosaminyl galactosyl glucosyl ceramide galactosyltransferase; GalT-4; paragloboside synthase; glucosaminyl galactosyl glucosyl ceramide 4-β-galactosyltransferase; lactotriaosylceramide 4-β-galactosyltransferase; UDP-galactose:N-acetyl-D-glucosam. Enzyme Commission Number: EC 2.4.1.86. CAS No. 9073-46-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2626; glucosaminyl galactosyl glucosyl ceramide β-galactosyltransferase; EC 2.4.1.86; 9073-46-5; uridine diphosphogalactose-acetyl -glucosaminyl galactosyl glucosyl ceramide galactosyltransferase; GalT-4; paragloboside synthase; glucosaminyl galactosyl glucosyl ceramide 4-β-galactosyltransferase; lactotriaosylceramide 4-β-galactosyltransferase; UDP-galactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide β-D-galactosyltransferase; UDP-Gal:LcOse3Cer(β 1-4)galactosyltransferase; UDP-galactose:N-acetyl-D-glucosaminyl-(1?3)-D-galactosyl-(1?4)-D-glucosylceramide 3-β-D-galactosyltransferase; UDP-galactose:N-acetyl-β-D-glucosaminyl-(1?3)-β-D-galactosyl-(1?4)-&be | |
| Glucosylsphingosine | Glucosylsphingosine (lyso-Gb1) is a deacylated form of glucosylceramide with neurotoxicity and is also a noncompetitively inhibitor of glucocerebrosidase with a K i value of 30 μM. Glucosylsphingosine is promising for research of Krabbe and Gaucher disease [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Natural products. Alternative Names: Glucopsychosine; Lyso-Gb1. CAS No. 52050-17-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N7745. | |
| Ibiglustat | Ibiglustat is a selective Glucosylceramide synthase inhibitor. It can block the formation of glucosylceramide (GL-1) which is a key intermediate in the synthesis of GL-3. In Oct 2016, Genzyme completed a phase II trial in Fabry's disease (Treatment-naïve) in USA, Czech Republic, France, Poland, Russia and the UK. Phase-II clinical trials in Gaucher's disease in USA is on-going. Uses: Fabry's disease; gaucher's disease. Synonyms: GZ-402671; GZ402671; GZ 402671; SSAR402671; SAR-402671; SAR 402671; Genz-682452-AA; Ibiglustat; GZ-452; Genz-682452; GZ 452; Genz 682452; GZ452; Genz682452; (3S)-1-azabicyclo[2.2.2]octan-3-yl N-{2-[2-(4-fluorophenyl)- 1,3-thiazol-4-yl]propan-2-yl}carbamate. Grades: 98%. CAS No. 1401090-53-6. Molecular formula: C20H24FN3O2S. Mole weight: 389.49. | |
| Ibiglustat | Ibiglustat (Venglustat) is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Venglustat; SAR402671; GZ402671. CAS No. 1401090-53-6. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16743. | |
| Ibiglustat succinate | Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat succinate can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Venglustat succinate; SAR402671 succinate; GZ402671 succinate. CAS No. 1629063-80-4. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16743B. | |
| Isofagomine hydrochloride | Isofagomine hydrochloride is a vital compound widely used in the biomedical industry for the research of lysosomal storage diseases such as Gaucher's disease. This product acts as an inhibitor of the enzyme glucosylceramide synthase, which helps in reducing the accumulation of harmful lipids in the lysosomes. Synonyms: (3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol; 5-Hydroxymethyl-3,4-piperidinediol; Afegostat. CAS No. 161302-93-8. Molecular formula: C6H13NO3 HCl. Mole weight: 183.63. | |
| Lactosylceramide | Lactosylceramide, a vital glycosphingolipid molecule, plays an essential role in cell signaling, cell migration, and apoptosis, and is intricately involved in regulating inflammation and immune responses. Synonyms: Ceramide b-lactoside; Ceramide dihexoside (CDH); b-D-Galactosyl-(1-4)-D-glucosylceramide; Lactosyl-N-acylsphingosine; LacCer. CAS No. 4682-48-8. | |
| lactosylceramide 1,3-N-acetyl-β-D-glucosaminyltransferase | This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. Group: Enzymes. Synonyms: LA2 synthase; β1?3-N-acetylglucosaminyltransferase; uridine diphosphoacetylglucosamine-lactosylceramide β-acetylglucosaminyltransferase; lactosylceramide β-acetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-β-D-glucosylceramide β-1,3-acetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:β-D-galactosyl-(1?4)-β-D-glucosyl(1<->1)ceramide 3-β-N-acetylglucosaminyltransferase. Enzyme Commission Number: EC 2.4.1.206. CAS No. 83682-80-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2433; lactosylceramide 1,3-N-acetyl-β-D-glucosaminyltransferase; EC 2.4.1.206; 83682-80-8; LA2 synthase; β1?3-N-acetylglucosaminyltransferase; uridine diphosphoacetylglucosamine-lactosylceramide β-acetylglucosaminyltransferase; lactosylceramide β-acetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-β-D-glucosylceramide β-1,3-acetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:β-D-galactosyl-(1?4)-β-D-glucosyl(1<->1)ceramide 3-β-N-acetylglucosaminyltransferase. Cat No: EXWM-2433. | |
| L-threo-PPMP hydrochloride | L-threo-PPMP is an inhibitor of glucosylceramide synthetase. Synonyms: L-threo-PPMP HCl; L-threo-1-phenyl-2-Palmitoylamino-3-morpholino-1-propanol hydrochloride; N-[(1R,2R)-1-hydroxy-3-morpholin-4-yl-1-phenylpropan-2-yl]hexadecanamide hydrochloride. Grades: ≥98%. CAS No. 207278-87-3. Molecular formula: C29H50N2O3·HCl. Mole weight: 511.18. | |
| Lucerastat | Lucerastat, the galactose form of Miglustat, is an orally-available inhibitor of glucosylceramide synthase (GCS). Lucerastat has the potential for Fabry disease study [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NB-DGJ; N-(n-Butyl)deoxygalactonojirimycin. CAS No. 141206-42-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106392. | |
| Miglustat HCl | Miglustat HCl is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1). It also inhibits glucosidase I and II, as well as HIV-1 and HIV-2 infection of peripheral blood mononuclear cells (PBMCs). Synonyms: Miglustat hydrochloride. Grades: 98%. CAS No. 210110-90-0. Molecular formula: C10H21NO4 HCl. Mole weight: 255.74. | |
| monosialoganglioside sialyltransferase | May be identical with EC 2.4.99.4 β-galactoside α-2,3-sialyltransferase. Group: Enzymes. Synonyms: CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetylneuraminyltransferase; CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl(1<->1)ceramide N-acetylneuraminyltransferase; CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-(1<->1)-ceramide N-acetylneuraminyltransferase. Enzyme Commission Number: EC 2.4.99.2. CAS No. 60202-12-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2704; monosialoganglioside sialyltransferase; EC 2.4.99.2; 60202-12-2; CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetylneuraminyltransferase; CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl(1<->1)ceramide N-acetylneuraminyltransferase; CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-(1<->1)-ceramide N-acetylneuraminyltransferase. Cat No: EXWM-2704. | |
| N-(7-Oxa-9,9,9-trifluorononyl)deoxynojirimycin | N-(7-Oxa-9,9,9-trifluorononyl)deoxynojirimycin is a potent inhibitor used in the biomedical industry for studying diseases associated with glycosphingolipid metabolism. It specifically targets the activity of glucosylceramide synthase, inhibiting the production of glucosylceramide, which plays a vital role in conditions like Gaucher disease and Fabry disease. Synonyms: N-(7-Oxa-9,9,9-trifluorononyl)deoxynojirimycin; 383417-50-3; (2R,3R,4R,5S)-2-(HYDROXYMETHYL)-1-[6-(2,2,2-TRIFLUOROETHOXY)HEXYL]PIPERIDINE-3,4,5-TRIOL; (2R,3R,4R,5S)-2-(Hydroxymethyl)-1-[6-(2,2,2-trifluoroethoxy)hexyl]-3,4,5-piperidinetriol; DTXSID201123508; W-202585. CAS No. 383417-50-3. Molecular formula: C13H24F3NO5. Mole weight: 331.33. | |
| N-acetyl neuraminyl galactosyl glucosyl ceramide β-1,4-N-acetylgalactosaminyltransferase | Requires Mn2+. Only substances containing sialic acid residues can act as acceptors; bovine fetuin is the best acceptor tested. Group: Enzymes. Synonyms: uridine diphosphoacetylgalactosamine-acetylneuraminyl(α 2?3)galactosyl(β 1?4)glucosyl β1?4-acetylgalactosaminyltransferase; UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-2,3-α-D-g. Enzyme Commission Number: EC 2.4.1.165. CAS No. 109136-50-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2390; N-acetyl neuraminyl galactosyl glucosyl ceramide β-1,4-N-acetylgalactosaminyltransferase; EC 2.4.1.165; 109136-50-7; uridine diphosphoacetylgalactosamine-acetylneuraminyl(α 2?3)galactosyl(β 1?4)glucosyl β1?4-acetylgalactosaminyltransferase; UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-2,3-α-D-galactosyl-1,4-β-D-glucosylceramide β-1,4-N-acetylgalactosaminyltransferase; UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-(2?3)-α-D-galactosyl-(1?4)-β-D-glucosyl(1<->1)ceramide 4-β-N-acetylgalactosaminyltransferase; UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-(2?3)-α-D-galactosyl-(1?4)-β-D-glucosyl-(1<->1)-ceramide 4-β-N-acetylgalactosaminyltransferase. Cat No: EXWM-2390. | |
| N-Methyldeoxynojirimycin | N-Methyldeoxynojirimycin is a remarkably efficacious inhibitor applied extensively in the research of hereditary disorders, including Gaucher's disease and Tay-Sachs disease. This phenomenal compound operates by suppressing the enzymatic activity of glucosidase, thereby inducing a noteworthy decline in the concentrations of glucosylceramide and glycolipids. Synonyms: 1,5-Dideoxy-1,5-imino-1-methyl-D-sorbitol; N-Me-DNJ. CAS No. 69567-10-8. Molecular formula: C7H15NO4. Mole weight: 177.2. | |
| N-(n-Butyl)deoxygalactonojirimycin | Lucerastat is a selective α-D-galactosidase inhibitor. It can prevent glucosylceramide biosynthesis both in vitro and in mouse models of lysosome storage disorders through inhibiting the ceramide-specific glucosyltransferase, UDP-glucose ceramide glucosyltransferase (IC50 = 41.4 μM) but it does not affect α-glucosidase I and II or β-glucocerebrosidase (IC50s > 1 mM). In Jul 2016, Actelion completed phase Ib trial in Fabry's disease,but no development was reported for the treatment of Lipid metabolism disorders. Uses: Lipid storage disorders and fabry's disease. Synonyms: N-Butyl-1,5-dideoxy-1,5-imino-D-galactitol. Grades: 95%. CAS No. 141206-42-0. Molecular formula: C10H21NO4. Mole weight: 219.28. | |
| PDMP hydrochloride | PDMP hydrochloride is a glucosylceramide synthase (GCS) inhibitor. PDMP hydrochloride induces apoptosis in K562/A02 cells. PDMP hydrochloride can be used in cancer (such as leukemia) research [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 73257-80-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-116392D. | |
| sphingolipid C9-methyltransferase | The enzyme, characterized from the fungi Komagataella pastoris and Fusarium graminearum, acts only on ceramides and has no activity with free sphingoid bases or glucosylceramides. Group: Enzymes. Enzyme Commission Number: EC 2.1.1.317. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1925; sphingolipid C9-methyltransferase; EC 2.1.1.317. Cat No: EXWM-1925. | |
| sphingomyelin deacylase | The enzyme is involved in the sphingolipid metabolism in the epidermis. Group: Enzymes. Synonyms: SM deacylase; GcSM deacylase; glucosylceramide sphingomyelin deacylase; sphingomyelin glucosylceramide deacylase; SM glucosylceramide GCer deacylase; SM-GCer deacylase; SMGCer deacylase. Enzyme Commission Number: EC 3.5.1.109. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4388; sphingomyelin deacylase; EC 3.5.1.109; SM deacylase; GcSM deacylase; glucosylceramide sphingomyelin deacylase; sphingomyelin glucosylceramide deacylase; SM glucosylceramide GCer deacylase; SM-GCer deacylase; SMGCer deacylase. Cat No: EXWM-4388. | |
| TP-060 | Glucosylceramide synthase-IN-1 (T-036) a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC 50 s of 31 nM and 51 nM for human GCS and mouse GCS, respectively. Glucosylceramide synthase-IN-1 can be used for Gaucher's disease research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Glucosylceramide synthase-IN-1. CAS No. 2601393-20-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144266. | |
| Conduritol B epoxide | Conduritol B epoxide (CBE) is an irreversible inhibitor of covalently bound acid β-glucosidase, also known as GBA, or GBA1 (IC50 = 9 μM). It also does not inhibit non-lysosomal glucosylceramidase or cytosolic β-glucosidase. Synonyms: CBE; 1,2-anhydro-myo-inositol. Grades: ≥95%. CAS No. 6090-95-5. Molecular formula: C6H10O5. Mole weight: 162.1. | |
| glucosylceramidase | Also acts on glucosylsphingosine (cf. EC 3.2.1.62 glycosylceramidase). Group: Enzymes. Synonyms: psychosine hydrolase; glucosphingosine glucosylhydrolase; GlcCer-β-glucosidase; β-D-glucocerebrosidase; glucosylcerebrosidase; β-glucosylceramidase; ceramide glucosidase; glucocerebrosidase; glucosylsphingosine β-glucosidase; glucosylsphingosine β-D-glucosidase. Enzyme Commission Number: EC 3.2.1.45. CAS No. 37228-64-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3908; glucosylceramidase; EC 3.2.1.45; 37228-64-1; psychosine hydrolase; glucosphingosine glucosylhydrolase; GlcCer-β-glucosidase; β-D-glucocerebrosidase; glucosylcerebrosidase; β-glucosylceramidase; ceramide glucosidase; glucocerebrosidase; glucosylsphingosine β-glucosidase; glucosylsphingosine β-D-glucosidase. Cat No: EXWM-3908. | |
| glycosylceramidase | Broad specificity [cf. EC 3.2.1.45 (glucosylceramidase) and EC 3.2.1.46 (galactosylceramidase)]. Also hydrolyses phlorizin to phloretin and glucose. The intestinal enzyme is a complex that also catalyses the reaction of EC 3.2.1.108 lactase. Group: Enzymes. Synonyms: phlorizin hydrolase; phloretin-glucosidase; glycosyl ceramide glycosylhydrolase; cerebrosidase; phloridzin β-glucosidase; lactase-phlorizin hydrolase; phloridzin glucosidase. Enzyme Commission Number: EC 3.2.1.62. CAS No. 9033-10-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3926; glycosylceramidase; EC 3.2.1.62; 9033-10-7; phlorizin hydrolase; phloretin-glucosidase; glycosyl ceramide glycosylhydrolase; cerebrosidase; phloridzin β-glucosidase; lactase-phlorizin hydrolase; phloridzin glucosidase. Cat No: EXWM-3926. | |
| Isofagomine | Isofagomine, an imino pyranose compound, has been found to be a glucosylceramidase stimulant and could exhibit activity in Gaucher's disease. Synonyms: (3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol; Isofagomine; Iso-Fagomine. Grades: 98%. CAS No. 169105-89-9. Molecular formula: C6H13NO3. Mole weight: 147.17. | |
| Isofagomine D-Tartrate | The D-Tartrate salt form of Isofagomine, an imino pyranose compound, has been found to be a glucosylceramidase stimulant and could exhibit activity in Gaucher's disease. Synonyms: (3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol (2S,3S)-2,3-dihydroxysuccinate; AT2101; AT-2101, AT 2101; Isofagomine D-Tartrate; Isofagomine; Afegostat; D-Isofagomine; isoFagomine brand name: Plicera. Grades: 98%. CAS No. 957230-65-8. Molecular formula: C10H19NO9. Mole weight: 297.26. | |
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