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| Product | Description | |
|---|---|---|
| 1,2-Dideoxy-2-fluoronojirimycin | 1,2-Dideoxy-2-fluoronojirimycin is a potent biological inhibitor employed in the research of Gaucher Disease. It can inhibit glucosylceramide synthase, responsible for the disease's metabolic dysfunction, thus helping to manage its symptoms effectively. CAS No. 134336-23-5. Molecular formula: C6H12NO3F. Mole weight: 165.16. |  |
| 1,6-Dideoxy-L-altronojirimycin | 1,6-Dideoxy-L-altronojirimycin is a pharmaceutical compound used for the treatment of Gaucher disease. It functions as an inhibitor of glucosylceramide synthase, which causes an accumulation of glucocerebrosides in cells affected by the disease. Synonyms: 1,5,6-Trideoxy-1,5-imino-D-altritol. CAS No. 168252-99-1. Molecular formula: C6H13NO3. Mole weight: 147.17. | |
| 2,3,4,6-Tetra-O-benzyl-1-L-ido-miglustat | 2,3,4,6-Tetra-O-benzyl-1-L-ido-miglustat is a useful reagent in preparation of pharmaceutically active aza-sugar piperidine derivatives as inhibitors of galactosidase and glucosylceramide synthase. Group: Biochemicals. Grades: Highly Purified. CAS No. 441061-29-6. Pack Sizes: 10mg, 25mg. Molecular Formula: C38H45NO4, Molecular Weight: 579.77. US Biological Life Sciences. |  Worldwide |
| Biotin-Lactosylceramide | Biotin-Lactosylceramide is a biotinylated conjugate of Lactosylceramide. Biotin-Lactosylceramide can be bound to streptavidin coated surfaces such as plates or beads. Lactosylceramide (LacCer), synthesized from β-glucosylceramide by lactosylceramide synthase in the Golgi, is a ubiquitous sphingolipid in mammalian tissue. Lactosylceramide is important in many cellular functions such as cell proliferation, migration, adhesion, and angiogenesis. Synonyms: Biotin-LacCer. Molecular formula: C46H82N4O15S. Mole weight: 963.24. | |
| ceramide glucosyltransferase | Sphingosine and dihydrosphingosine can also act as acceptors; CDP-glucose can act as donor. Group: Enzymes. Synonyms: UDP-glucose:ceramide glucosyltransferase; ceramide:UDP-Glc glucosyltransferase; uridine diphosphoglucose-ceramide glucosyltransferase; ceramide:UDP-glucose glucosyltransferase; glucosylceramide synthase; UDP-glucose:N-acylsphingosine D-glucosyltransferase. Enzyme Commission Number: EC 2.4.1.80. CAS No. 37237-44-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2621; ceramide glucosyltransferase; EC 2.4.1.80; 37237-44-8; UDP-glucose:ceramide glucosyltransferase; ceramide:UDP-Glc glucosyltransferase; uridine diphosphoglucose-ceramide glucosyltransferase; ceramide:UDP-glucose glucosyltransferase; glucosylceramide synthase; UDP-glucose:N-acylsphingosine D-glucosyltransferase. Cat No: EXWM-2621. |  |
| DL-threo-PDMP hydrochloride | DL-threo-PDMP hydrochloride is the hydrochloride form of DL-threo-PDMP that is a competitive glucosylceramide synthase ( GCS ) inhibitor. DL-threo-PDMP resensitizes refractory testicular germ cell tumors and epithelial ovarian cancer orthoxenografts to cisplatin in mice [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 80938-69-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-116392B. |  |
| DL-threo-PDMP hydrochloride | DL-threo PDMP is a mixture of ceramide analogs that contains two of the four possible stereoisomers of PDMP: D-threo (1R,2R) and L-threo (1S,2S) PDMP. DL-threo-PDMP inhibits glucosylceramide synthase by 33 and 48% in MDCK cell homogenates when used at concentrations of 5 and 10 μM. It reduces the synthesis of glucosylceramide, increases cellular ceramide, and induces cell cycle arrest in vitro. Synonyms: DL-PDMP; D,l-Threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol HCl; SMR000326846. Grade: ≥98%. CAS No. 80938-69-8. Molecular formula: C23H38N2O3·HCl. Mole weight: 427. | |
| DL-threo-PPMP hydrochloride | DL-threo-PPMP is a ceramide analog that inhibits glucosylceramide synthase. It has been used to study the role of glucosylceramide synthase in cell growth, apoptosis, and autophagy. Synonyms: DL-threo-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol; DL-PPMP; BML3-D12; CTK8E7792. Grade: ≥98%. CAS No. 139974-41-7. Molecular formula: C29H50N2O3·HCl. Mole weight: 511.2. | |
| (+)-D-threo-PDMP hydrochloride | (+)-D-threo-PDMP is a ceramide analog and is one of the four possible stereoisomers of PDMP. (+)-D-threo-PDMP is an inhibitor of glucosylceramide synthase. Synonyms: d-threo-PDMP; 109836-82-0; 80938-69-8; (+)-D-threo-PDMP (hydrochloride); DL-threo-PDMP (hydrochloride); 139889-62-6; N-[(1R,2R)-1-hydroxy-3-morpholin-4-yl-1-phenylpropan-2-yl]decanamide; hydrochloride; N-[(1R,2R)-2-Hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-decanamide, monohydrochloride; SMR000326846; DL-threo-PDMP; (+/-)-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol hydrochloride; D-Threo-pdmp-HCl; MLS000859987; MLS002153295; BML3-D11; CHEMBL1255585; EX-A8002H; DTXSID401017468; D-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL; AKOS040755898; J-002336; D-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol*HCl; N-((1R,2R)-1-hydroxy-3-morpholino-1-phenylpropan-2-yl)decanamide hydrochloride; Decanamide,N-[(1R,2R)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-,hydrochloride(1:1),rel-. Grade: ≥98%. CAS No. 139889-62-6. Molecular formula: C23H38N2O3·HCl. Mole weight: 427.03. | |
| D-threo-PDMP hydrochloride | D-threo-PDMP hydrochloride is a glucosylceramide (GlcCer) synthase inhibitor that inhibits glucosylceramide (GlcCer) and lactosylceramide (LacCer) levels in B16 melanoma cells. D-threo-PDMP hydrochloride lacks reactivity to the other two surface antigens anti-melanoma monoclonal antibodies M562 and M622 and the major histocompatibility antigen anti-H-2KbDb monoclonal antibody, so it is specific for B16 melanoma sex [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 139889-62-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-116392F. | |
| Eliglustat | Eliglustat is a glucosylceramide synthase inhibitor indicated for the long-term treatment of type 1 Gaucher disease in patients who are CYP2D6 extensive metabolizers, intermediate metabolizers , or poor metabolizers in treatment-naive and treatment-experi. Uses: Inhibits glucosylceramide synthase(gcs). Synonyms: Genz-99067; Genz 99067; Genz99067; N-[(1R,2R)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-pyrrolidin-1-ylpropan-2-yl]octanamide. Grade: ≥98%. CAS No. 491833-29-5. Molecular formula: C23H36N2O4. Mole weight: 404.55. | |
| Eliglustat hemitartrate | Eliglustat hemitartrate is a specific inhibitor of glucosylceramide synthase. It is under development as an oral substrate reduction therapy for Gaucher disease type 1 (GD1). It was developed by Genzyme Corp and has been listed by the FDA August 2014. Synonyms: Genz-112638; Genz 112638; Genz112638; Eliglustat tartrate; Bis(N-((1R,2R)-2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(pyrrolidin-1- ylmethyl)ethyl)octanamide) (2R,3R)-2,3-dihydroxybutanedioate; Octanamide, N-((1R,2R)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1- pyrrolidinylmethyl)ethyl)-, (2R,3R)-2,3-dihydroxybutanedioate; N-[(1R,2R)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-pyrrolidin-1-ylpropan-2-yl]octanamide (2R,3R)-2,3-dihydroxybutanedioic acid. Grade: >98%. CAS No. 928659-70-5. Molecular formula: C50H78N4O14. Mole weight: 959.17. | |
| Genz-123346 free base | Genz-123346 free base is an orally available inhibitor of glucosylceramide synthase. Genz-123346 blocks the conversion of ceramide to glucosylceramide (GL1) and inhibits GM1 with an IC50 of 14 nM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 491833-30-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12744. | |
| Genz-123346 Free base | Genz-123346 is a glucosylceramide synthase inhibitor with potential anticancer activity. Exposure of cells to Genz-123346 and to other GCS inhibitors at non-toxic concentrations can enhance the killing of tumor cells by cytotoxic anti-cancer agents. Genz-123346 and a few other GCS inhibitors are substrates for multi-drug resistance efflux pumps such as P-gp (ABCB1, gP-170). In cell lines selected to over-express P-gp or which endogenously express P-gp, chemosensitization by Genz-123346 was primarily due to the effects on P-gp function. Synonyms: Genz-123346; Genz123346; Genz 123346. CAS No. 491833-30-8. Molecular formula: C24H38N2O4. Mole weight: 418.57. | |
| globoside α-N-acetylgalactosaminyltransferase | This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. Group: Enzymes. Synonyms: uridine diphosphoacetylgalactosamine-globoside α-acetylgalactosaminyltransferase; Forssman synthase; globoside acetylgalactosaminyltransferase; UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide α-N-acetyl-D-galactosaminyltransferase; UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-(1?3)-D-galactosyl-(1?4)-D-galactosyl-(1?4)-D-glucosyl-(1<->1)-ceramide α-N-ace. Enzyme Commission Number: EC 2.4.1.88. CAS No. 52037-97-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2628; globoside α-N-acetylgalactosaminyltransferase; EC 2.4.1.88; 52037-97-5; uridine diphosphoacetylgalactosamine-globoside α-acetylgalactosaminyltransferase; Forssman synthase; globoside acetylgalactosaminyltransferase; UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide α-N-acetyl-D-galactosaminyltransferase; UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-(1?3)-D-galactosyl-(1?4)-D-galactosyl-(1?4)-D-glucosyl-(1<->1)-ceramide α-N-acetyl-D-galactosaminyltransferase. Cat No: EXWM-2628. | |
| glucosaminyl galactosyl glucosyl ceramide β-galactosyltransferase | This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. Group: Enzymes. Synonyms: uridine diphosphogalactose-acetyl -glucosaminyl galactosyl glucosyl ceramide galactosyltransferase; GalT-4; paragloboside synthase; glucosaminyl galactosyl glucosyl ceramide 4-β-galactosyltransferase; lactotriaosylceramide 4-β-galactosyltransferase; UDP-galactose:N-acetyl-D-glucosam. Enzyme Commission Number: EC 2.4.1.86. CAS No. 9073-46-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2626; glucosaminyl galactosyl glucosyl ceramide β-galactosyltransferase; EC 2.4.1.86; 9073-46-5; uridine diphosphogalactose-acetyl -glucosaminyl galactosyl glucosyl ceramide galactosyltransferase; GalT-4; paragloboside synthase; glucosaminyl galactosyl glucosyl ceramide 4-β-galactosyltransferase; lactotriaosylceramide 4-β-galactosyltransferase; UDP-galactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide β-D-galactosyltransferase; UDP-Gal:LcOse3Cer(β 1-4)galactosyltransferase; UDP-galactose:N-acetyl-D-glucosaminyl-(1?3)-D-galactosyl-(1?4)-D-glucosylceramide 3-β-D-galactosyltransferase; UDP-galactose:N-acetyl-β-D-glucosaminyl-(1?3)-β-D-galactosyl-(1?4)-&be | |
| glucosylceramide β-1,4-galactosyltransferase | Involved in the synthesis of several different major classes of glycosphingolipids. Group: Enzymes. Synonyms: lactosylceramide synthase; uridine diphosphate-galactose:glucosyl ceramide β 1-4 galactosyltransferase; UDP-Gal:glucosylceramide β1?4galactosyltransferase; GalT-2 (misleading); UDP-galactose:β-D-glucosyl-(1<->1)-ceramide β-1,4-galactosyltransferase. Enzyme Commission Number: EC 2.4.1.274. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2506; glucosylceramide β-1,4-galactosyltransferase; EC 2.4.1.274; lactosylceramide synthase; uridine diphosphate-galactose:glucosyl ceramide β 1-4 galactosyltransferase; UDP-Gal:glucosylceramide β1?4galactosyltransferase; GalT-2 (misleading); UDP-galactose:β-D-glucosyl-(1<->1)-ceramide β-1,4-galactosyltransferase. Cat No: EXWM-2506. | |
| Glucosylceramide (Soy) | Glucosylceramide is synthesised enzymatically, by the glucosylceramide synthase-catalysed with the addition of a glucose residue to ceramide. They are present in neuronal and non-neuronal mammalian tissues and are found at low quantities in a large number of plant species, where they comprise 5-30% of total lipids in the plant plasma membrane, and in fungi. Synonyms: Cerebroside (Soy); GlcCer(d18:2/16:0). Grade: >99%. CAS No. 497155-61-0. Molecular formula: C40H75NO9. Mole weight: 714.03. | |
| Ibiglustat | Ibiglustat is a selective Glucosylceramide synthase inhibitor. It can block the formation of glucosylceramide (GL-1) which is a key intermediate in the synthesis of GL-3. In Oct 2016, Genzyme completed a phase II trial in Fabry's disease (Treatment-naïve) in USA, Czech Republic, France, Poland, Russia and the UK. Phase-II clinical trials in Gaucher's disease in USA is on-going. Uses: Fabry's disease; gaucher's disease. Synonyms: Venglustat; GZ-402671; GZ402671; GZ 402671; SSAR402671; SAR-402671; SAR 402671; Genz-682452-AA; GZ-452; Genz-682452; GZ 452; Genz 682452; GZ452; (S)-Quinuclidin-3-yl (2-(2-(4-fluorophenyl)thiazol-4-yl)propan-2-yl)carbamate. Grade: 98%. CAS No. 1401090-53-6. Molecular formula: C20H24FN3O2S. Mole weight: 389.49. | |
| Ibiglustat | Ibiglustat (Venglustat) is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Venglustat; SAR402671; GZ402671. CAS No. 1401090-53-6. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16743. | |
| Ibiglustat succinate | Ibiglustat succinate is a glucosylceramide synthase inhibitor. It can block the formation of glucosylceramide (GL-1) which is a key intermediate in the synthesis of GL-3. Synonyms: Venglustat succinate; Ibiglustat L-malate. CAS No. 1629063-78-0. Molecular formula: C24H30FN3O7S. Mole weight: 523.6. | |
| Ibiglustat succinate | Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat succinate can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Venglustat succinate; SAR402671 succinate; GZ402671 succinate. CAS No. 1629063-80-4. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16743B. | |
| lactosylceramide 1,3-N-acetyl-β-D-glucosaminyltransferase | This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. Group: Enzymes. Synonyms: LA2 synthase; β1?3-N-acetylglucosaminyltransferase; uridine diphosphoacetylglucosamine-lactosylceramide β-acetylglucosaminyltransferase; lactosylceramide β-acetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-β-D-glucosylceramide β-1,3-acetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:β-D-galactosyl-(1?4)-β-D-glucosyl(1<->1)ceramide 3-β-N-acetylglucosaminyltransferase. Enzyme Commission Number: EC 2.4.1.206. CAS No. 83682-80-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2433; lactosylceramide 1,3-N-acetyl-β-D-glucosaminyltransferase; EC 2.4.1.206; 83682-80-8; LA2 synthase; β1?3-N-acetylglucosaminyltransferase; uridine diphosphoacetylglucosamine-lactosylceramide β-acetylglucosaminyltransferase; lactosylceramide β-acetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-β-D-glucosylceramide β-1,3-acetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:β-D-galactosyl-(1?4)-β-D-glucosyl(1<->1)ceramide 3-β-N-acetylglucosaminyltransferase. Cat No: EXWM-2433. | |
| Lucerastat | Lucerastat, the galactose form of Miglustat, is an orally-available inhibitor of glucosylceramide synthase (GCS). Lucerastat has the potential for Fabry disease study [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NB-DGJ; N-(n-Butyl)deoxygalactonojirimycin. CAS No. 141206-42-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106392. | |
| (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase | This enzyme catalyses the formation of the gangliosides (i.e. sialic-acid-containing glycosphingolipids) GM2, GD2 and SM2 from GM3, GD3 and SM3, respectively. Asialo-GM3 and lactosylceramide are also substrates, but glycoproteins and oligosaccharides are not substrates. Group: Enzymes. Synonyms: uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase; ganglioside GM2 synthase; ganglioside GM3 acetylgalactosaminyltransferase; GM2 synthase; UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide acetylgalactosaminyltransferase; UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-α-neuraminyl)-(2?3)-O-β-D-galactopyranosyl-(1?4)-β-D-glucopyranosyl]-ceramide 1,4-β-N-acetyl-D-galactosaminyltransferase acetylgalactosa. Enzyme Commission Number: EC 2.4.1.92. CAS No. 67338-98-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2632; (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase; EC 2.4.1.92; 67338-98-1; uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase; ganglioside GM2 synthase; ganglioside GM3 acetylgalactosaminyltransferase; GM2 synthase; UDP acetylgalactosamine-(N-acetylneuraminyl)-D-gal | |
| PDMP hydrochloride | PDMP hydrochloride is a glucosylceramide synthase (GCS) inhibitor. PDMP hydrochloride induces apoptosis in K562/A02 cells. PDMP hydrochloride can be used in cancer (such as leukemia) research [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 73257-80-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-116392D. | |
| TP-060 | Glucosylceramide synthase-IN-1 (T-036) a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC 50 s of 31 nM and 51 nM for human GCS and mouse GCS, respectively. Glucosylceramide synthase-IN-1 can be used for Gaucher's disease research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Glucosylceramide synthase-IN-1. CAS No. 2601393-20-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144266. | |
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