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| Product | Description | |
|---|---|---|
| glucuronosyltransferase | This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. Group: Enzymes. Synonyms: 1-naphthol glucuronyltransferase; 1-naphthol-UDP-glucuronosyltransferase; 17β-hydroxysteroid UDP-glucuronosyltransferase; 3α-hydroxysteroid UDP-glucuronosyltransferase; 4-hydroxybiphenyl UDP-glucuronosyltransferase; 4-methylumbelliferone UDP-glucuronosyltransferase; 4-nitrophenol UDP-glucuronyltransferase; 4-nitrophenol UDPGT; 17-OH steroid UDPGT; 3-OH androgenic UDPGT; bilirubin uridine diphosphoglucuronyltransferase; bilirubin UDP-glucuronosyltransferase; bilirubin monoglucuronide glucuronyltransferase; bilirubin UDPGT; bilirubin glucuronyltransferase; ciramadol UDP-glucuronyltransferase; estriol UDP-glucuronosyltransferase; estrone UDP-glucuronosyltransferase; uridine diphosphoglucuronosyltransferase; uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase; uridine diphosphoglucuronate-bilirubin glucuronosyltransferase; uridine diphosphoglucuronate-estriol glucuronosyltransferase; uridine diphosphoglucuronate-estradiol glucuronosyltransferase; uridine diphosphoglucuronate-4-hydroxybiphenyl gl |  |
| baicalein 7-O-glucuronosyltransferase | The enzyme is specific for UDP-D-glucuronate as a sugar donor and flavones with substitution ortho- to the 7-OH group such as baicalein (6-OH), scutellarein (6-OH) and wogonin (8-OMe). Group: Enzymes. Synonyms: UBGAT. Enzyme Commission Number: EC 2.4.1.253. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2483; baicalein 7-O-glucuronosyltransferase; EC 2.4.1.253; UBGAT. Cat No: EXWM-2483. | |
| bilirubin-glucuronoside glucuronosyltransferase | This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is bilirubin-glucuronoside:bilirubin-glucuronoside D-glucuronosyltransferase. Other names in common use include bilirubin monoglucuronide transglucuronidase, and bilirubin glucuronoside glucuronosyltransferase. Group: Enzymes. Synonyms: bilirubin monoglucuronide transglucuronidase; bilirubin glucuronoside glucuronosyltransferase. Enzyme Commission Number: EC 2.4.1.95. CAS No. 71822-22-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2634; bilirubin-glucuronoside glucuronosyltransferase; EC 2.4.1.95; 71822-22-5; bilirubin monoglucuronide transglucuronidase; bilirubin glucuronoside glucuronosyltransferase. Cat No: EXWM-2634. | |
| cyanidin-3-O-glucoside 2''-O-glucuronosyltransferase | The enzyme is highly specific for cyanidin 3-O-glucosides and UDP-α-D-glucuronate. Involved in the production of glucuronosylated anthocyanins that are the origin of the red coloration of flowers of Bellis perennis. Group: Enzymes. Synonyms: BpUGT94B1; UDP-glucuronic acid:anthocyanin glucuronosyltransferase; UDP-glucuronic acid:anthocyanidin 3-glucoside 2'-O-β-glucuronosyltransferase; BpUGAT; UDP-D-glucuronate:cyanidin-3-O-β-glucoside 2-O-β-glucuronosyltransferase. Enzyme Commission Number: EC 2.4.1.254. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2484; cyanidin-3-O-glucoside 2''-O-glucuronosyltransferase; EC 2.4.1.254; BpUGT94B1; UDP-glucuronic acid:anthocyanin glucuronosyltransferase; UDP-glucuronic acid:anthocyanidin 3-glucoside 2'-O-β-glucuronosyltransferase; BpUGAT; UDP-D-glucuronate:cyanidin-3-O-β-glucoside 2-O-β-glucuronosyltransferase. Cat No: EXWM-2484. | |
| dolichyl N-acetyl-α-D-glucosaminyl phosphate 3-β-D-2,3-diacetamido-2,3-dideoxy-β-D-glucuronosyltransferase | The enzyme, characterized from the methanogenic archaeon Methanococcus voltae, participates in the N-glycosylation of proteins. Dolichol used by archaea is different from that used by eukaryotes. It is much shorter (C55-C60), it is α,ω-saturated and it may have additional unsaturated positions in the chain. Group: Enzymes. Synonyms: AglC; UDP-Glc-2,3-diNAcA glycosyltransferase. Enzyme Commission Number: EC 2.4.1.335. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2573; dolichyl N-acetyl-α-D-glucosaminyl phosphate 3-β-D-2,3-diacetamido-2,3-dideoxy-β-D-glucuronosyltransferase; EC 2.4.1.335; AglC; UDP-Glc-2,3-diNAcA glycosyltransferase. Cat No: EXWM-2573. | |
| galactosylgalactosylxylosylprotein 3-β-glucuronosyltransferase | Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+. Group: Enzymes. Synonyms: glucuronosyltransferase I; uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase; UDP-glucuronate:3-β-D-galactosyl-4-β-D-galactosyl-O-β-D-xylosyl-protein D-glucuronosyltransferase; UDP-glucuronate:3-β-D-galactosyl-4-β-D-galactosyl-O-β-D-xylosylprotein D-glucuronosyltransferase. Enzyme Commission Number: EC 2.4.1.135. CAS No. 227184-75-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2360; galactosylgalactosylxylosylprotein 3-β-glucuronosyltransferase; EC 2.4.1.135; 227184-75-0; glucuronosyltransferase I; uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase; UDP-glucuronate:3-β-D-galactosyl-4-β-D-galactosyl-O-β-D-xylosyl-protein D-glucuronosyltransferase; UDP-glucuronate:3-β-D-galactosyl-4-β-D-galactosyl-O-β-D-xylosylprotein D-glucuronosyltransferase. Cat No: EXWM-2360. | |
| luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase | The enzyme participates in the biosynthesis of luteolin triglucuronide, the major flavone found in the photosynthetically-active mesophyll of the primary leaves of Secale cereale (rye). Group: Enzymes. Synonyms: uridine diphosphoglucuronate-luteolin 7-O-diglucuronide glucuronosyltransferase; UDP-glucuronate:luteolin 7-O-diglucuronide-glucuronosyltransferase; UDPglucuronate:luteolin 7-O-diglucuronide-4'-O-glucuronosyl-transferase; LDT; UDP-glucuronate:luteolin-7-O-β-D-diglucuronide 4'-O-glucuronosyltransferase. Enzyme Commission Number: EC 2.4.1.191. CAS No. 115490-50-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2418; luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase; EC 2.4.1.191; 115490-50-1; uridine diphosphoglucuronate-luteolin 7-O-diglucuronide glucuronosyltransferase; UDP-glucuronate:luteolin 7-O-diglucuronide-glucuronosyltransferase; UDPglucuronate:luteolin 7-O-diglucuronide-4'-O-glucuronosyl-transferase; LDT; UDP-glucuronate:luteolin-7-O-β-D-diglucuronide 4'-O-glucuronosyltransferase. Cat No: EXWM-2418. | |
| luteolin-7-O-glucuronide 2''-O-glucuronosyltransferase | The enzyme participates in the biosynthesis of luteolin triglucuronide, the major flavone found in the photosynthetically-active mesophyll of the primary leaves of Secale cereale (rye). Group: Enzymes. Synonyms: uridine diphosphoglucuronate-luteolin 7-O-glucuronide glucuronosyltransferase; LMT; UDP-glucuronate:luteolin 7-O-glucuronide-glucuronosyltransferase; UDP-glucuronate:luteolin-7-O-β-D-glucuronide 2''-O-glucuronosyltransferase. Enzyme Commission Number: EC 2.4.1.190. CAS No. 115490-51-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2417; luteolin-7-O-glucuronide 2''-O-glucuronosyltransferase; EC 2.4.1.190; 115490-51-2; uridine diphosphoglucuronate-luteolin 7-O-glucuronide glucuronosyltransferase; LMT; UDP-glucuronate:luteolin 7-O-glucuronide-glucuronosyltransferase; UDP-glucuronate:luteolin-7-O-β-D-glucuronide 2''-O-glucuronosyltransferase. Cat No: EXWM-2417. | |
| luteolin 7-O-glucuronosyltransferase | The enzyme participates in the biosynthesis of luteolin triglucuronide, the major flavone found in the photosynthetically-active mesophyll of the primary leaves of Secale cereale (rye). Group: Enzymes. Synonyms: uridine diphosphoglucuronate-luteolin 7-O-glucuronosyltransferase; LGT; UDP-glucuronate:luteolin 7-O-glucuronosyltransferase. Enzyme Commission Number: EC 2.4.1.189. CAS No. 115490-49-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2415; luteolin 7-O-glucuronosyltransferase; EC 2.4.1.189; 115490-49-8; uridine diphosphoglucuronate-luteolin 7-O-glucuronosyltransferase; LGT; UDP-glucuronate:luteolin 7-O-glucuronosyltransferase. Cat No: EXWM-2415. | |
| N-acetylgalactosaminyl-proteoglycan 3-β-glucuronosyltransferase | Involved in the biosynthesis of chondroitin and dermatan sulfate. The human chondroitin synthetase is a bifunctional glycosyltransferase, which has the 3-β-glucuronosyltransferase and 4-β-N-acetylgalactosaminyltransferase (EC 2.4.1.175) activities required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase 'co-polymerases' can be found in Pasteurella multocida and Escherichia coli. There is also another human protein with apparently only the 3-β-glucuronosyltransferase activity. Group: Enzymes. Synonyms: chondroitin glucuronyltransferase II; α-D-glucuronate:N-acetyl-β-D-galactosaminyl-(1?4)-β-D-glucuronosyl-proteoglycan 3-β-glucuronosyltransferase. Enzyme Commission Number: EC 2.4.1.226. CAS No. 269077-98-7. Chondroitin synthase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2455; N-acetylgalactosaminyl-proteoglycan 3-β-glucuronosyltransferase; EC 2.4.1.226; 269077-98-7; chondroitin glucuronyltransferase II; α-D-glucuronate:N-acetyl-β-D-galactosaminyl-(1?4)-β-D-glucuronosyl-proteoglycan 3-β-glucuronosyltransferase. Cat No: EXWM-2455. | |
| N-acetylglucosaminyl-proteoglycan 4-β-glucuronosyltransferase | Involved in the biosynthesis of heparin and heparan sulfate. Some forms of the human enzyme (particularly the enzyme complex encoded by the EXT1 and EXT2 genes) act as bifunctional glycosyltransferases, which also have the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-α-N-acetylglucosaminyltransferase (EC 2.4.1.224) activity required for the synthesis of the heparan sulfate disaccharide repeats. Group: Enzymes. Synonyms: N-acetylglucosaminylproteoglycan β-1,4-glucuronyltransferase; heparan glucuronyltransferase II. Enzyme Commission Number: EC 2.4.1.225. CAS No. 145539-84-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2454; N-acetylglucosaminyl-proteoglycan 4-β-glucuronosyltransferase; EC 2.4.1.225; 145539-84-0; N-acetylglucosaminylproteoglycan β-1,4-glucuronyltransferase; heparan glucuronyltransferase II. Cat No: EXWM-2454. | |
| soyasapogenol glucuronosyltransferase | Requires a divalent ion, Mg2+ better than Mn2+, better than Ca2+. Also acts on soysapogenol A and E. Group: Enzymes. Synonyms: UGASGT; UDP-D-glucuronate:soyasapogenol 3-O-D-glucuronosyltransferase. Enzyme Commission Number: EC 2.4.1.262. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2493; soyasapogenol glucuronosyltransferase; EC 2.4.1.262; UGASGT; UDP-D-glucuronate:soyasapogenol 3-O-D-glucuronosyltransferase. Cat No: EXWM-2493. | |
| 1-Naphthyl b-D-glucuronide sodium salt | 1-Naphthyl b-D-glucuronide sodium salt, an invaluable biomedicine, is employed extensively in scientific research to explore the intricate process of glucuronidation, which plays a vital role in the metabolism and elimination of a diverse array of pharmaceuticals and endogenous compounds. Acting as a versatile substrate, it facilitates the activities of glucuronosyltransferases, crucial enzymes that mediate glucuronidation reactions. Demonstrating immense utility in in vitro experiments, this product enables scientists to unravel the profound impact of glucuronidation on drug pharmacokinetics, while simultaneously facilitating the evaluation of potential drug-drug interactions. Synonyms: 1-Nap-b-D-GlcA.Na. CAS No. 83833-12-9. Molecular formula: C16H15NaO7. Mole weight: 342.28. |  |
| 1-Pyrenyl-2,3,4-tri-O-acetyl-b-D-glucuronide methyl ester | 1-Pyrenyl-2,3,4-tri-O-acetyl-b-D-glucuronide methyl ester is a compound primarily used in studying glucuronidation, a major phase II metabolic pathway. It can serve as a substrate in assays of UDP-glucuronosyltransferase, an enzyme increasingly targeted in drug development. Molecular formula: C29H26O10. Mole weight: 534.51. | |
| 3'-Azido-3'-deoxythymidine β-D-glucuronide sodium salt | 3'-Azido-3'-deoxythymidine β-D-glucuronide is a metabolite of the nucleoside reverse transcriptase inhibitor, zidovudine, formed by direct conjugation by UDP-glucuronosyltransferase 2B7. Synonyms: AZT glucuronide; Zidovudine glucuronide. Grades: ≥95%. CAS No. 133525-01-6. Molecular formula: C16H20N5O10·Na. Mole weight: 465.4. | |
| 4-Methylphenyl 2,3,4-tri-O-benzyl-b-D-thioglucuronide | 4-Methylphenyl 2,3,4-tri-O-benzyl-b-D-thioglucuronide is an eminent biomedical compound, efficaciously thwarting the functionality of glucuronosyltransferase enzymes. It plays a pivotal role in mediating pharmaceutical metabolism and detoxification mechanisms, offering prodigious prospects for comprehensive drug exploration. Synonyms: Toluoyl 1-thio-2,3,4-tri-O-benzyl-b-D-glucuronic acid. Molecular formula: C34H34O6S. Mole weight: 570.71. | |
| 5-Bromo-4-chloro-1H-indol-3-yl-b-D-glucuronide | 5-Bromo-4-chloro-1H-indol-3-yl-b-D-glucuronide is a notable glucuronide derivation of 5-Bromo-4-chloro-1H-indole, meticulously utilized as a probe within drug metabolism studies. This compound is commonly harnessed to evaluate the engagement of glucuronidation in the metabolic processes of specific medications, or to unlock the secrets pertaining to UDP-glucuronosyltransferase enzymes within drug elimination pathways. Synonyms: X-Glucuronide X-GlcA. CAS No. 18656-89-8. Molecular formula: C14H13BrClNO7. Mole weight: 422.61. | |
| Bakuchiol | Bakuchiol is a phytoestrogen that can be obtained from psoralen seeds. Bakuchiol has been proven to be a non-competitive inhibitor of multiple enzymes, including UDP-glucuronosyltransferase 2B7 ( UGT2B7 ) [2] and human carboxylesterase 2 ( hCE2 ) [3] , with IC 50 s values of 40.9 μM and 7.28 μM, respectively. Bakuchiol exhibits significant research and application potential in areas such as anti-inflammatory [5] , antibacterial [4] , antitumor [1] therapies, as well as drug metabolism regulation. Uses: Scientific research. Group: Natural products. Alternative Names: (S)-(+)-Bakuchiol. CAS No. 10309-37-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0235. |  |
| Cabotegravir | Cabotegravir (GSK-1265744) is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 ( OAT1 / OAT3 ) inhibitor with IC 50 values of 2.5 nM, 0.41 μM and 0.81 μM for HIV ADA , OAT3 and OAT1, respectively. Cabotegravir is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir can be used to research AIDS [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK-1265744; S/GSK1265744. CAS No. 1051375-10-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15592. | |
| Cabotegravir sodium | Cabotegravir (GSK-1265744) sodium is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 ( OAT1 / OAT3 ) inhibitor with IC 50 values of 2.5 nM, 0.41 μM and 0.81 μM for HIV ADA , OAT3 and OAT1, respectively. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir sodium can be used to research AIDS [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK-1265744 sodium; S/GSK1265744 sodium. CAS No. 1051375-13-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15592A. | |
| Chondroitin synthase from Pasteurella multocida, Recombinant | In enzymology, a N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase (EC 2.4.1.226) is an enzyme that catalyzes the chemical reaction: UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl- proteoglycan ? UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)- beta-D-glucuronosyl-proteoglycan. The 3 substrates of this enzyme are UDP-alpha-D-glucuronate, [[N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-]], and proteoglycan, whereas its 3 products are UDP, [[beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-]], and beta-D-glucuronosyl-proteoglycan. Group: Enzymes. Synonyms: alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glu curonosyl-proteoglycan 3-beta-glucuronosyltransferase; chondroitin glucuronyltransferase II; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferas. Enzyme Commission Number: EC 2.4.1.226. CAS No. 269077-98-7. Purity: min 95% by SDS-PAGE. Chondroitin synthase. Source: E. coli. Species: Pasteurella multocida. alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glu curonosyl-proteoglycan 3-beta-glucuronosyltransferase; chondroitin glucuronyltransferase II; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase; EC 2.4.1.226; Chondroitin synthase. Cat No: NATE-1486. | |
| Dapagliflozin-3-O-β-D-glucuronide | Dapagliflozin-3-O-β-D-glucuronide (BMS-801576) is the metabolite of Dapagliflozin (HY-10450), and is formed in the liver and kidney by uridine diphosphate glucuronosyltransferase-1A9 (UGT1A9). Dapagliflozin is a selective inhibitor for SGLT2 , that can be used to improve glycemic control and attenuate type 2 diabetes [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-801576. CAS No. 1351438-75-9. Pack Sizes: 500 μg; 1 mg. Product ID: HY-125156. | |
| Diclofenac-acyl-beta-D-glucuronide | Diclofenac-acyl-beta-D-glucuronide is a vital metabolite in the biotransformation of diclofenac, an NSAID, undergoing formation predominantly via liver uridine 5'-diphospho-glucuronosyltransferase enzymes. Its participation in the metabolism and elimination of diclofenac profoundly influences its pharmacokinetics and therapeutic efficacy for studying diverse inflammatory conditions. Synonyms: 1-O-[2-[(2,6-Dichlorophenyl)amino]phenylacetyl]-b-D-glucopyranuronic acid. Grades: > 95%. CAS No. 64118-81-6. Molecular formula: C20H19Cl2NO8. Mole weight: 472.27. | |
| Ethyl 2-amino-b-D-glucuronide | Ethyl 2-amino-beta-D-glucuronide is a remarkable compound, used for studying glucuronidation-related disorders and drug metabolism. Its multifaceted role as a substrate for UDP-glucuronosyltransferase enzymes is crucial in facilitating the conjugation of drugs and xenobiotics. Molecular formula: C8H15NO6. Mole weight: 221.21. | |
| Faldaprevir | Faldaprevir, also known as BI-201335, is a potent NS3/NS4A protease inhibitor potentially for the treatment of HCV infection. Faldaprevir is known to inhibit P-glycoprotein, CYP3A4, and UDP-glucuronosyltransferase 1A1. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Faldaprevir; BI-201335; BI 201335; BI201335. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 801283-95-4. Molecular formula: C40H49BrN6O9S. Mole weight: 869.83. Purity: >98%. IUPACName: (1R,2S)-1-((2S,4R)-4-((8-bromo-2-(2-isobutyramidothiazol-4-yl)-7-methoxyquinolin-4-yl)oxy)-1-((S)-2-(((cyclopentyloxy)carbonyl)amino)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-2-vinylcyclopropane-1-carboxylic acid. Canonical SMILES: O=C([C@]1(NC([C@H]2N(C([C@@H](NC(OC3CCCC3)=O)C(C)(C)C)=O)C[C@H](OC4=CC(C5=CSC(NC(C(C)C)=O)=N5)=NC6=C(Br)C(OC)=CC=C46)C2)=O)[C@H](C=C)C1)O. Product ID: ACM801283954. Alfa Chemistry ISO 9001:2015 Certified. |  |
| glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-β-N-acetylgalactosaminyltransferase | Involved in the biosynthesis of chondroitin sulfate. The human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-β-glucuronosyltransferase (EC 2.4.1.226, N-acetylgalactosaminyl-proteoglycan 3-β-glucuronosyltransferase) activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase 'co-polymerases' can be found in Pasteurella multocida and Escherichia coli. Group: Enzymes. Synonyms: N-acetylgalactosaminyltransferase II; UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-β-D-galactosaminylproteoglycan β-1,4-N-acetylgalactosaminyltransferase; cho...curonosyl-N-acetylgalactosaminyl-proteoglycan 4-β-N-acetylgalactosaminyltransferase; EC 2.4.1.175; 96189-40-1; N-acetylgalactosaminyltransferase II; UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-β-D-galactosaminylproteoglycan β-1,4-N-acetylgalactosaminyltransferase; chondroitin synthase; glucuronyl-N-acetylgalactosaminylproteoglycan β-1,4-N-acetylgalactosaminyltransferase; uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II; UDP-N-acetyl-D-galactosamine:β-D-glucuronosyl-(1?3)-N-acetyl-β-D-galactosaminyl-proteoglycan 4-β-N-acetylgalactosaminyltransferase. Cat No: EXWM-2400. | |
| glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-α-N-acetylglucosaminyltransferase | Involved in the biosynthesis of heparin and heparan sulfate. Some forms of the enzyme from human (particularly the enzyme complex encoded by the EXT1 and EXT2 genes) act as bifunctional glycosyltransferases, which also have the 4-β-glucuronosyltransferase (EC 2.4.1.225, N-acetylglucosaminyl-proteoglycan 4-β-glucuronosyltransferase) activity required for the synthesis of the heparan sulfate disaccharide repeats. Other human forms of this enzyme (e.g. the product of the EXTL1 gene) have only the 4-α-N-acetylglucosaminyltransferase activity. In Caenorhabditis elegans, the product of the rib-2 gene displays the activities of this enzyme as well as EC 2.4.1.223, glucuronosyl-galactosyl-proteoglycan 4-α-N-acetylglucosaminyltransferase. Group: Enzymes. Synonyms: α-N-acetylglucosaminyltransferase II glucuronyl-. Enzyme Commission Number: EC 2.4.1.224. CAS No. 336193-98-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2453; glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-α-N-acetylglucosaminyltransferase; EC 2.4.1.224; 336193-98-7; α-N-acetylglucosaminyltransferase II glucuronyl-N-acetylglucosaminylproteoglycan α-1,4-N-acetylglucosaminyltransferase. Cat No: EXWM-2453. | |
| Hecogenin | Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects [1]. Uses: Scientific research. Group: Natural products. CAS No. 467-55-0. Pack Sizes: 5 mg; 10 mg; 20 mg; 50 mg. Product ID: HY-N1422. | |
| Hecogenin | Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: White powder. CAS No. 467-55-0. Molecular formula: C27H42O4. Mole weight: 430.62. Purity: 0.98. Canonical SMILES: CC1CCC2(C(C3C(O2)CC4C3(C(=O)CC5C4CCC6C5(CCC(C6)O)C)C)C)OC1. Product ID: ACM467550. Alfa Chemistry ISO 9001:2015 Certified. | |
| Licochalcone A | Licochalcone A (LCA), a flavonoid isolated, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs) [1]. Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC 50 and K i values lower than 5 μM) [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Licochalcone-A. CAS No. 58749-22-7. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0372. | |
| Methyl b-D-glucuronide sodium salt | Methyl b-D-glucuronide sodium salt is a chemical compound used in the biomedical industry for its role in drug metabolism studies. It is commonly employed as a substrate to evaluate glucuronidation reactions mediated by glucuronosyltransferase enzymes. This product aids in understanding drug metabolism and its implications in treating various diseases by facilitating the study of drug elimination pathways. Synonyms: Methyl b-D-glucuronic acid sodium salt; 1-OMe-b-D-GlcA. Na. CAS No. 134253-42-2. Molecular formula: C7H11NaO7. Mole weight: 230.15. | |
| Phenyl b-D-thioglucuronide | Phenyl b-D-thioglucuronide, an invaluable compound in the biomedical industry, stands at the forefront of drug metabolism studies and hepatic glucuronidation research. As a substrate for glucuronosyltransferase enzymes, this compound diligently unravels the intricate web of drug-drug interactions and illuminates the identities of drugs undergoing glucuronidation. Synonyms: (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-phenylsulfanyloxane-2-carboxylic acid; Phenyl 1-thio-beta-D-glucopyranosiduronic acid; FYJ. CAS No. 26399-82-6. Molecular formula: C12H14O6S. Mole weight: 286.30. | |
| Raltegravir Potassium Salt | Raltegravir is a potent, selective, and orally bioavailable inhibitor of HIV integrase (IC50 = 15 nM). It is metabolized primarily by uridine diphosphate glucuronosyltransferase 1A. Raltegravir has long-term efficacy and safety in managing HIV-1 infection in adults, children, and adolescents. Uses: Anti-hiv agents. Synonyms: MK-0518; MK 0518; MK0518; Raltegravir. Grades: 98%. CAS No. 871038-72-1. Molecular formula: C20H20FKN6O5. Mole weight: 482.514. | |
| RO6889678 | RO6889678 is an inhibitor of HBV with a complex ADME profile. RO6889678 showed an intracellular enrichment of 78-fold in hepatocytes, with an apparent intrinsic clearance of 5.2 μl/min per mg protein and uptake and biliary clearances of 2.6 and 1.6 μl/min per mg protein, respectively. The induction potential of RO6889678 on cytochrome P450 (P450) enzymes and transporters at steady state was assessed and cotreatment with ritonavir revealed a complex drug-drug interaction with concurrent P450 inhibition and moderate UDP-glucuronosyltransferase induction. Uses: Designed for use in research and industrial production. Additional or Alternative Names: RO6889678; RO-6889678; RO 6889678. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1578153-27-1. Molecular formula: C21H20ClFN4O5S. Mole weight: 494.92. Purity: >98%. IUPACName: (S)-4-(((R)-6-(2-Chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholine-3-carboxylic acid. Canonical SMILES: O=C([C@H]1N(CC2=C(C(OC)=O)[C@H](C3=CC=C(F)C=C3Cl)N=C(C4=NC=CS4)N2)CCOC1)O. Product ID: ACM1578153271. Alfa Chemistry ISO 9001:2015 Certified. | |
| Salicylamide | Salicylamide is an inhibitor of microsomal UDP-glucuronosyltransferase. Salicylamide is an analgesic and anti-pyretic agent. Uses: Scientific research. Group: Natural products. Alternative Names: 2-Hydroxybenzamide. CAS No. 65-45-2. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 10 g. Product ID: HY-B0811. | |
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