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| Product | Description | |
|---|---|---|
| ADP-ribosylation factor GTPase-activating protein 3 (152-160) | A fragment of ADP-ribosylation factor GTPase-activating protein 3. ARFGAP3 (ADP Ribosylation Factor GTPase Activating Protein 3) is a Protein Coding gene. Diseases associated with ARFGAP3 include Phelan-Mcdermid Syndrome and Ceroid Lipofuscinosis, Neuronal, 4B, Autosomal Dominant. This peptide can be used in Ovarian carcinoma research. |  |
| dGTPase | Also acts on GTP. Group: Enzymes. Synonyms: deoxy-GTPase; deoxyguanosine 5-triphosphate triphosphohydrolase; deoxyguanosine triphosphatase; deoxyguanosine triphosphate triphosphohydrolase. Enzyme Commission Number: EC 3.1.5.1. CAS No. 9025-63-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3741; dGTPase; EC 3.1.5.1; 9025-63-2; deoxy-GTPase; deoxyguanosine 5-triphosphate triphosphohydrolase; deoxyguanosine triphosphatase; deoxyguanosine triphosphate triphosphohydrolase. Cat No: EXWM-3741. |  |
| dynamin GTPase | An enzyme with a molecular mass of about 100 kDa that is involved in endocytosis and is instrumental in pinching off membrane vesicles. Group: Enzymes. Enzyme Commission Number: EC 3.6.5.5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4716; dynamin GTPase; EC 3.6.5.5. Cat No: EXWM-4716. | |
| heterotrimeric G-protein GTPase | This group comprises GTP-hydrolysing systems, where GTP and GDP alternate in binding. This group includes stimulatory and inhibitory G-proteins such as Gs, Gi, Go and Golf, targetting adenylate cyclase and/or K+ and Ca2+ channels; Gq stimulating phospholipase C; transducin activating cGMP phosphodiesterase; gustducin activating cAMP phosphodiesterase. Golf is instrumental in odour perception, transducin in vision and gustducin in taste recognition. At least 16 different α subunits (39-52 kDa), 5 β subunits (36 kDa) and 12 γ subunits (6-9 kDa) are known. Group: Enzymes. Enzyme Commission Number: EC 3.6.5.1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4712; heterotrimeric G-protein GTPase; EC 3.6.5.1. Cat No: EXWM-4712. | |
| protein-synthesizing GTPase | This enzyme comprises a family of proteins involved in prokaryotic as well as eukaryotic protein synthesis. In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP and subsequently hydrolyses it in prokaryotes. In eukaryotes, it is eIF-2 (150 kDa) that binds GTP. In the elongation phase, the GTP-hydrolysing proteins are the EF-Tu polypeptide of the prokaryotic transfer factor (43 kDa), the eukaryotic elongation factor EF-1α (53 kDa), the prokaryotic EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal recognition particle that play a role in endoplasmic reticulum protein synthesis (325 kDa). EF-Tu and EF-1α catalyse binding of aminoacyl-tRNA to the ribosomal A-site, while EF-G and EF-2 catalyse the translocation of peptidyl-tRNA from the A-site to the P-site. GTPase activity is also involved in polypeptide release from the ribosome with the aid of the pRFs and eRFs. Group: Enzymes. Synonyms: elongation factor (EF); initiation factor (IF); peptide-release or termination factor. Enzyme Commission Number: EC 3.6.5.3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4714; protein-synthesizing GTPase; EC 3.6.5.3; elongation factor (EF); initiation factor (IF); peptide-release or termination factor. Cat No: EXWM-4714. | |
| Ras Superfamily GTPases GTP/GDP Binding Antagonist, CID 1067700 | A thiourea-derived small molecule that acts as a competitive inhibitor of nucleotide (BODIPY-GTP and BODIPY-GDP) binding by Rab7 (Ki=12.89-19.70nM). Equilibrates rapidly with Rab7 without affecting the rate of release of bound BODIPY-GTP or BODIPY-GDP. However, it exhibits a slightly lower potency against BODIPY-GDP bound Rab7 than BODIPY-GTP bound Rab7A. Acts by binding to the nucleotide binding pocket of Rab7. Also shown to inhibit nucleotide binding by mutant forms of Rab7 (Rab7Q67L and Rab7T22N) that are constitutively in the GTP and GDP bound states, with good potency. Also shown to block the nucleotide binding of several other Ras-related GTPases, but with reduced potency. Group: Biochemicals. Grades: Highly Purified. CAS No. 314042-01-8. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S?, Primary Target: Rab7. US Biological Life Sciences. |  Worldwide |
| signal-recognition-particle GTPase | Activity is associated with the signal-recognition particle (a protein- and RNA-containing structure involved in endoplasmic-reticulum-associated protein synthesis). Group: Enzymes. Enzyme Commission Number: EC 3.6.5.4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4715; signal-recognition-particle GTPase; EC 3.6.5.4. Cat No: EXWM-4715. | |
| small monomeric GTPase | A family of about 50 enzymes with a molecular mass of 21 kDa that are distantly related to the α-subunit of heterotrimeric G-protein GTPase (EC 3.6.5.1). They are involved in cell-growth regulation (Ras subfamily), membrane vesicle traffic and uncoating (Rab and ARF subfamilies), nuclear protein import (Ran subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies). Group: Enzymes. Enzyme Commission Number: EC 3.6.5.2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4713; small monomeric GTPase; EC 3.6.5.2. Cat No: EXWM-4713. | |
| tubulin GTPase | An intrinsic activity of α-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others. Group: Enzymes. Enzyme Commission Number: EC 3.6.5.6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4717; tubulin GTPase; EC 3.6.5.6. Cat No: EXWM-4717. | |
| 1-Demethylcolchicine | 1-Demethylcolchicine is a derivative of Colchicine (C640000) an antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 3464-68-4. Pack Sizes: 10mg, 50mg. Molecular Formula: C21H23NO6, Molecular Weight: 385.41. US Biological Life Sciences. | Worldwide |
| 1-Palmito-2-stearin | 1-Palmito-2-stearin is a diacylglycerol used to increase the activity of the ARF1 GTPase-activating protein on membrane-bound ARF1GTP. Group: Biochemicals. Grades: Highly Purified. CAS No. 20296-26-8. Pack Sizes: 10mg, 100mg. Molecular Formula: C37H72O5. US Biological Life Sciences. | Worldwide |
| 1-Palmito-2-stearin-d5 | 1-Palmito-2-stearin-d5 is labelled 1-Palmito-2-stearin (P144980) which is a diacylglycerol used to increase the activity of the ARF1 GTPase-activating protein on membrane-bound ARF1GTP. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C37H67D5O5, Molecular Weight: 602. US Biological Life Sciences. | Worldwide |
| 1-Palmitoyl-2-oleoyl-rac-glycerol-d5 | 1-Palmitoyl-2-oleoyl-rac-glycerol-d5 is labelled 1-Palmitoyl-2-oleoyl-rac-glycerol (P160950) which is a monounsaturated diacylglycerol used to increase the activity of the ARF1 GTPase-activating protein on membrane-bound ARF1GTP. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C37H65D5O5, Molecular Weight: 599.98. US Biological Life Sciences. | Worldwide |
| 2,3,5-Tri-O-acetyl-6-chloropurine-9-β-D-ribofuranoside | A nucleoside compound with inhibitory activity on a rho-GTPase cell protein. Synonyms: 6-Chloro-9-β-D-ribofuranosyl-9H-purine 2',3',5'-Triacetate; 2',3',5'-Tri-O-acetyl-6-chloronebularine; 6-Chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine; 6-Chloro-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)purine; NSC 281799. Grades: 95%. CAS No. 5987-73-5. Molecular formula: C16H17ClN4O7. Mole weight: 412.78. | |
| 2- (Benzoyl carbamothioyl amino) -5, 5-di methyl -4, 7-di hydrothieno [2, 3-c] pyran-3-carboxyl ic Acid | This compound acts as a novel GTPase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 314042-01-8. Pack Sizes: 1mg, 5mg, 10mg, 25mg. Molecular Formula: C18H18N2O4S2, Molecular Weight: 390.48. US Biological Life Sciences. | Worldwide |
| 2'-Deoxyadenosine-5'-O-(1-Thiotriphosphate) | 2'-Deoxyadenosine-5'-O-(1-Thiotriphosphate) - a specialized nucleotide - is typically employed in biochemical assays that evaluate the functioning of enzymes, including kinases and GTPases. Its inclusion in such assays is aimed at exploring the intricate mechanics of protein phosphorylation and nucleotide exchange in the aforementioned enzymes. Synonyms: Alpha Thiol dATP; 1-Thio-dATP. Grades: ≥95% by AX-HPLC. Molecular formula: C10H16N5O11P3S. Mole weight: 507.25. | |
| 2-Hydroxy-benzoic Acid [1- (2-Hydroxyphenyl) ethylidene]hydrazide | 2-Hydroxy-benzoic Acid [1- (2-Hydroxyphenyl) ethylidene]hydrazide is a GTPase-activating protein (SH3 domain)-binding protein 2 (G3BP2) inhibitor. G3BP2 is involved with breast tumor initiation. Group: Biochemicals. Grades: Highly Purified. CAS No. 15533-09-2. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C15H14N2O3, Molecular Weight: 270.279999999999. US Biological Life Sciences. | Worldwide |
| 3'-(O-Propargyl)-GTP | 3'-(O-Propargyl)-GTP, a non-hydrolyzable GTP analog, is widely used in scientific research to examine the functions of GTPases in signal transduction and protein synthesis. Furthermore, it is renowned for its potential to detect prospective inhibitors of GTPase activity. This biochemical compound is indispensable to researchers and scholars alike, as its scientific applications hold tremendous promise for the advancement of molecular biology. Synonyms: 3'-(O-Propargyl)-guanosine-5'-triphosphate, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C13H18N5O14P3 (free acid). Mole weight: 561.23. | |
| 5-Iodouridine | It is a Rho-GTPase cell protein inhibitor. Synonyms: NSC 523375; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dione; 2,4-Dihydroxy-5-iodo-1-β-D-ribofuranosylpyrimidine; 5-Iodo-1-(β-D-ribofuranosyl)uracil. Grades: ≥95%. CAS No. 1024-99-3. Molecular formula: C9H11IN2O6. Mole weight: 370.10. | |
| 6-Methylthio-GTP | 6-Methylthio-GTP, a pivotal determinant in the bio-mechanisms modulating GTPase activity, renders itself an irreplaceable asset for biomedical studies analyzing post-translational modifications. By examining its interactions with effectors proteins in the context of diseases spanning from cancer to neurodegenerative disorders, this compound furthers our understanding of the intricate workings of the human body and aids in the fight against various ailments. Synonyms: 6-Methylthioguanosine-5'-triphosphate, Sodium salt. Grades: ≥ 95% by HPLC. CAS No. 70318-62-6. Molecular formula: C11H18N5O13P3S (free acid). Mole weight: 553.27 (free acid). | |
| 8-[(4-Amino)butyl]-amino-ADP - MANT | 8-[(4-Amino)butyl]-amino-ADP - MANT is a fluorescent derivative of ADP, which primarily functions as a substrate for various enzymes involved in energy metabolism. It has been used to study the catalytic activity of enzymes such as kinases and GTPases. Additionally, it has been used in drug discovery and screening of potential inhibitors against diseases associated with abnormalities in energy metabolism such as cancer and heart diseases. Synonyms: (MABA-ADP); 8-[(4-Amino)butyl]-amino-adenosine-5'-diphosphate, labeled with MANT, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C22H32N8O11P2 (free acid). Mole weight: 646.48 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-GTP - 5-FAM | 8-[(6-Amino)hexyl]-amino-GTP - 5-FAM is a fluorescently labeled biochemical compound commonly used in biomedical research. It is a modified form of Guanosine-5'-triphosphate (GTP) that contains a 5-carboxyfluorescein (5-FAM) dye molecule and an amino-hexyl spacer. This compound is especially valuable for studying GTP-binding proteins, nucleotide exchange assays and monitoring GTPase activity. Its fluorescence enables real-time visualization and quantification of GTP-related processes in drug discovery, cellular signaling and disease mechanisms. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate, labeled with 5 FAM, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C37H40N7O20P3 (free acid). Mole weight: 995.68 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-GTP - 6-JOE | 8-[(6-Amino)hexyl]-amino-GTP - 6-JOE, a fluorescently-labeled analog of guanosine triphosphate (GTP), serves as a fundamental tool in biochemical research, enabling the exploration of GTP-binding proteins' function and activity. Additionally, this compound proves invaluable for detecting GTPase activity across a myriad of cellular processes. Its numerous applications cement its place as a critical component in any laboratory focused on biological experimentation. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate, labeled with 6-JOE, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C39H41Cl2N6O23P3 (free acid). Mole weight: 1124.08 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-GTP - ATTO-465 | 8-[(6-Amino)hexyl]-amino-GTP - ATTO-465 is a fluorescently-labeled GTP analog commonly used in biomedicine to study GTPases and their functions in signaling pathways. It can also be used to monitor the activity of various disease-related proteins, including those involved in cancer and neurological disorders. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate, labeled with ATTO 465, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C33H45N10O15P3 (free acid). Mole weight: 914.69 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-GTP - ATTO-532 | 8-[(6-Amino)hexyl]-amino-GTP - ATTO-532 serving as an exemplary fluorescently labeled guanosine triphosphate (GTP) derivative exclusively employed as a quintessential probe for scrutinizing nucleotide binding studies and a remarkable marker for GTPase activity. Its spectroscopic highlight lies in its vivid green fluorescence emission, making it an unparalleled investigative instrument for visualizing GTP-dependent procedures in vivo as well as monitoring intricate protein interactions. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate, labeled with ATTO 532, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C45H59N10O23P3S2 (free acid). Mole weight: 1264.24 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-GTP - ATTO-540Q | 8-[(6-Amino)hexyl]-amino-GTP - ATTO-540Q is a cutting-edge fluorescent probe employed for studying cellular signaling pathways, specifically for investigating GTPase-dependent processes. This powerful tool enables the visualization and monitoring of GTPase activity. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate, labeled with ATTO 540Q, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H30N7O14P3- ATTO 540Q (free acid). Mole weight: 1177.37 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-GTP - ATTO-594 | 8-[(6-Amino)hexyl]-amino-GTP - ATTO-594 is a multifaceted fluorescent probe embodying an array of applications for biomedical research. It bears the unique ability to detect nucleotide binding and hydrolysis alongside small molecule-GTPase interactions. With its unparalleled power to illuminate the dynamic activities of GTPases engaged in cell signaling pathways, this fluorescent probe stands as a formidable asset to cellular explorations. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate, labeled with ATTO 594, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H30N7O14P3- ATTO 594 (free acid). Mole weight: 1424.37 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-GTP - ATTO-647N | 8-[(6-Amino)hexyl]-amino-GTP - ATTO-647N is a fluorescent nucleotide analog used in biochemical and biomedical research to study GTPase activities and signaling pathways. Its high fluorescent intensity and photostability make it ideal for live cell imaging and superresolution microscopy. This product is particularly useful in studying neurological disorders, including Alzheimer's and Parkinson's diseases. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate, labeled with ATTO 647N, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H30N7O14P3- ATTO 647N (free acid). Mole weight: 1264.37 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-GTP - ATTO-665 | 8-[(6-Amino)hexyl]-amino-GTP - ATTO-665, a fluorescent analog of GTP, functions as a critical resource for the investigation of GTP-binding proteins in cancer and neurological disease research. Its in vitro utilization enables the examination of GTPase enzyme dynamics, especially in their association with effector proteins. The product's existence enhances comprehension regarding the different GTP-controlled cellular events that participate in the progression of various diseases that afflict humanity. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate, labeled with ATTO 665, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H30N7O14P3- ATTO 665 (free acid). Mole weight: 1241.37 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-GTP - ATTO-Rho101 | 8-[(6-Amino)hexyl]-amino-GTP - ATTO-Rho101, an essential fluorescent dye for investigating GTPase activity and binding in biological assays, is an exquisite addition to scientific experimentation. The dye is particularly valuable when coupled with Rho GTPases that yield intriguing insights into important cellular activities such as cytoskeletal rearrangement and cell migration. Moreover, the dye's versatility is a cause for praise as it can be employed to label and visualize subcellular structures, including but not limited to mitochondria. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate, labeled with ATTO Rho101, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C53H67N10O17P3 (free acid). Mole weight: 1208.39 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-GTP - ATTO-Rho12 | 8-[(6-Amino)hexyl]-amino-GTP - ATTO-Rho12, an exquisite fluorescent nucleotide analog, serves as an illuminating tool for studying GTP-binding proteins and their multifaceted functions. This remarkable dye has demonstrated unparalleled efficacy in experimental setups designed to scrutinize the kinetics and activity of various GTPases in cells. The vivid fluorescence of the compound transforms GTPase activity into a mesmerizing safari in vivo. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate, labeled with ATTO Rho12, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C57H79N10O17P3 (free acid). Mole weight: 1268.48 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-GTP - ATTO-Rho14 | 8-[(6-Amino)hexyl]-amino-GTP is a vital tool in the biomedical industry used to study and investigate various cellular processes acting as a fluorescent nucleotide analog, allowing for visualization and tracking of GTPase activity. Particularly, It finds application in the study of cellular signaling pathways and the role of GTPases in diseases such as cancer and neurological disorders. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate, labeled with ATTO Rho14, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C57H71Cl4N10O17P3 (free acid). Mole weight: 1400.30 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-GTP - Biotin | 8-[(6-Amino)hexyl]-amino-GTP - Biotin, a biochemical product, finds its application in exploring cell signaling pathways and G protein-coupled receptor (GPCR) signaling. Besides working as a probe for GTPases, it serves as a substrate for enzymatic assays to track G-protein activation or GTP concentration in cells. Also, it is a famous material for affinity purification, allowing researchers to isolate target proteins during chromatography. Overall, this versatile compound amplifies the scope of cell biology-related inquiries in both academia and industry. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate - Biotin, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C26H44N9O16P3S (free acid). Mole weight: 863.66 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-GTP - DY-480XL | DY-480XL is a fluorescent probe used in the biomedical industry for live cell imaging of small GTPases. Specifically, 8-[(6-Amino)hexyl]-amino-GTP acts as a substrate for GTPases, allowing for visualization of their activity in relation to drug treatments or disease states. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate, labeled with DY 480XL, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C42H58N9O20P3S (free acid). Mole weight: 1133.95 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-GTP - DY-751 | Designed for biomedical research, 8-[(6-Amino)hexyl]-amino-GTP - DY-751 is a potent and selective inhibitor used in studies related to GTP-binding proteins. It facilitates the exploration of GTPases' role in cellular signaling and disease states such as cancer, neurodegenerative disorders is and cardiovascular diseases. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate, labeled with DY 751, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C58H80N9O22P3S2 (free acid). Mole weight: 1411.41 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-GTP - MANT | 8-[(6-Amino)hexyl]-amino-GTP - MANT, a chemical compound regularly employed within the biomedicine industry to track the activity of GTPases proteins that regulate crucial cellular processes, demonstrates high sensitivity and specificity. This multifunctional compound has proven incredibly useful in both clinical and basic research for studying various GTPases, notably those involved in devastating neurological disorders such as Alzheimer's and Parkinson's diseases. Its versatile applications make it a vital tool in modern biomedical research. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate, labeled with MANT, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C24H37N8O15P3 (free acid). Mole weight: 770.52 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-GTP - OYSTER-656 | 8-[(6-Amino)hexyl]-amino-GTP is an indispensable compound extensively utilized in the research of diverse afflictions, particularly those entailing the intricate GTPase signaling pathways. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate, labeled with OYSTER 656, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H30N7O14P3- OYSTER 656 (free acid). Mole weight: 1353.35 (free acid). | |
| 8-Bromo-GDP | 8-Bromo-GDP is an exemplary and formidable analogue of guanosine diphosphate (GDP), facilitating the research of GTP-binding proteins and the mechanisms of signaling pathways, protein enmeshment and GTPase activity. Synonyms: (8Br-GDP); 8-Bromo-guanosine-5'-diphosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C10H14N5O11P2Br (free acid). Mole weight: 522.09 (free acid). | |
| 8-Bromo-GTP | 8-Bromo-GTP is a GTP analog that can inhibit GTP-hydrolase. It competitively inhibits GTPase (IC50 = 32 μM) and competes with ATP for the binding center of RNA-polymerase. Synonyms: (8Br-GTP); 8-Bromo-guanosine-5'-triphosphate, Sodium salt. Grades: ≥ 95% by HPLC. CAS No. 23197-98-0. Molecular formula: C10H15N5O14P3Br (free acid). Mole weight: 602.07 (free acid). | |
| 8-CPT-2Me-cAMP sodium | 8-CPT-2Me-cAMP sodium is a selective activator of exchange proteins activated by cAMP (Epac) , the cAMP sensitive guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2. 8-CPT-2Me-cAMP sodium activates Epac1 ( EC 50=2.2 μM), but not PKA ( EC 50 > 10 μM) [1]. 8-CPT-2Me-cAMP sodium stimulates Epac-mediated Ca 2+ release in pancreatic β-cells in vitro [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 634207-53-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-107543. |  |
| Ant-GTP | Ant-GTP is a crucial recompound for studying GTP-binding protein playing a significant role in elucidating the functions of GTPases such as cell signaling, protein research and development and vesicle transport. By providing a stable source of GTP, ant-GTP facilitates the investigation of various diseases associated with GTPase dysregulation, including cancer, neurodegenerative disorders and cardiovascular diseases. Synonyms: 2'/3'-O-Anthraniloyl-guanosine-5'-triphosphate, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C17H21N6O15P3 (free acid). Mole weight: 642.30 (free acid). | |
| Anti-BetaGamma (MPS-Phosducin-like protein C terminus) | It is a membrane-permeable phosphoducin-like anti-βγ peptide, whose membrane-permeable sequence (MPS) is derived from the C-terminal residues of phosducin-like protein (PhLP). This region of PhLP has been shown to confer interactions with Gβ?-mediated signaling. Specifically, it inhibits the activity of Go GTPase, demonstrates the ability to bind Gβγ, and inhibits the Gβγ-enhanced rhodopsin phosphorylation via βARK. The PhLP shares amino acid sequence homology with phosphoducin, a phosphoprotein expressed in the retina and pineal gland. Synonyms: H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Val-Thr-Asp-Gln-Leu-Gly-Glu-Asp-Phe-Phe-Ala-Val-Asp-Leu-Glu-Ala-Phe-Leu-Gln-Glu-Phe-Gly-Leu-Leu-Pro-Glu-Lys-Glu-OH. Grades: ≥95%. Molecular formula: C217H340N46O63. Mole weight: 4601.36. | |
| Arachidonic acid | Arachidonic acid is an essential fatty acid and a precursor in the biosynthesis of thromboxanes, prostaglandins and leukotrienes. It is a transient, critical substrate for the biosynthesis of eicosanoid second messengers. It is an important cellular signaling mediator in a variety of biological processes, including smooth chemotaxis, muscle contraction, apoptosis, cell proliferation and differentiation. It exits in liver, brain, glandular organs, and depot fats of animals and a constituent of animal phosphatides. It could bind to the subunit of G protein and inhibit the activity of Ras GTPase-activating proteins (GAPs). It stimulates adhesion of MDA-MB-435 human metastatic cancer cells to extracellular matrix molecules. Synonyms: Arachidonate. Grades: 98 %. CAS No. 506-32-1. Molecular formula: C20H32O2. Mole weight: 304.47. | |
| Arachidonic acid-[13C20] | Labelled Arachidonic acid. Arachidonic acid is an essential fatty acid and a precursor in the biosynthesis of thromboxanes, prostaglandins and leukotrienes. It is a transient, critical substrate for the biosynthesis of eicosanoid second messengers. It is an important cellular signaling mediator in a variety of biological processes, including smooth chemotaxis, muscle contraction, apoptosis, cell proliferation and differentiation. It exits in liver, brain, glandular organs, and depot fats of animals and a constituent of animal phosphatides. It could bind to the subunit of G protein and inhibit the activity of Ras GTPase-activating proteins (GAPs). It stimulates adhesion of MDA-MB-435 human metastatic cancer cells to extracellular matrix molecules. Grades: > 98%. Molecular formula: [13C]20H32O2. Mole weight: 324.32. | |
| BQU57 | BQU57, a derivative of RBC8, is a selective GTPase Ral inhibitor relative to the GTPases Ras and RhoA. Synonyms: BQU57; BQU 57; BQU-57. Grades: >98%. CAS No. 1637739-82-2. Molecular formula: C16H13F3N4O. Mole weight: 334.1. | |
| CASIN | CASIN is a selective GTPase Cdc42 inhibitor (IC50=2 uM), reducing active levels of Cdc42 in aged hematopoietic stem cells. Uses: Cdc42 gtpase inhibitor. Synonyms: 2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol. Grades: >98%. CAS No. 425399-05-9. Molecular formula: C20H22N2O. Mole weight: 306.41. | |
| CASIN | CASIN is a selective GTPase Cdc42 inhibitor with an IC 50 of 2 uM. CASIN can be used for the research of cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 425399-05-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12874. | |
| CCG-63802 | CCG-63802 is a reversible inhibitor of regulator of G-protein signaling (RGS) protein. It is selective amongst RGS proteins, with greatest potency at RGS4. It also inhibits GTPase accelerating protein activity of RGS4, blocks its interaction with Gαo, and retains activity under reducing conditions. Synonyms: CCG-4986; CCG 4986; CCG4986. Grades: >98%. CAS No. 620112-78-9. Molecular formula: C26H18N4O2S. Mole weight: 450.51. | |
| CID 1067700 | CID 1067700 is a Rab7 GTPase inhibitor exhibiting significant inhibitory potency against Rab7 nucleotide binding with nanomolar inhibitor (Ki) values and an inhibitory response of ≥97% for BODIPY-GTP and BODIPYGDP binding (Ki values 13 nM and 19 nM, and EC50 values 11 and 21 nM, respectively). CID 1067700 is a competitive guanine nucleotide binding inhibitor. Synonyms: CID 1067700; CID1067700; 2-(3-benzoylthioureido)-5,5-dimethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylic acid; MLS000673908; ML282; SMR000297947; CID-1067700. Grades: 99%. CAS No. 314042-01-8. Molecular formula: C18H18N2O4S2. Mole weight: 390.48. | |
| Clathrin-IN-4 | Clathrin-IN-4 (compound 8b), a Wiskostatin (HY-12534) analogue, is a potent inhibitor of clathrin mediated endocytosis with an IC 50 of 2.1 μM. Clathrin-IN-4 is a dynamin I GTPase activity inhibitor with an IC 50 of 9.1 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 762242-59-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152218. | |
| dGDPαS | dGDPαS, a guanine nucleotide analog, is a petite molecule immensely employed in exploring GTPases, critical proteins playing crucial roles in several cellular paths. It has a remarkable utility in investigating drug mechanisms targeted at GTPases and studying illnesses like cancer, inflammatory diseases, and neurodegenerative disorders. Its varied applications in the biomedical industry have elevated its popularity and importance. Synonyms: 2'-Deoxyguanosine-5'-(α-thio)-diphosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C10H15N5O9P2S (free acid). Mole weight: 443.26 (free acid). | |
| dGppNHp | dGppNHp is a modified nucleotide widely employed in studying intricate protein kinase signaling pathways. Serving as a non-hydrolyzable analog of GTP, this indispensable biochemical entity assumes a pivotal role in experimental investigations, particularly those concerning GTPases. Synonyms: (dGMPPNP); 2'-Deoxyguanosine-5'-[(β,γ)-imido]triphosphate, Sodium salt. Grades: ≥ 90% by HPLC. Molecular formula: C10H17N6O12P3 (free acid). Mole weight: 506.20 (free acid). | |
| Dynamin Inhibitor V, 34-2 (2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-indol-3-yl)-acrylamide) | A cell-permeable, allosteric Dynamin inhibitor (IC50=6.9uM and 14uM for full length Dynamin I and Dynamin II GTPase activity, respectively, in vitro). 10uM of this compound results in cytokinesis failure at the abscission stage in HeLa cultures, with 82% of cells that enter into mitosis becoming multinucleated, and with 97% resulting in cell death. However, it displays a much reduced effect in NIH3T3 cells at the same concentration. It elicits a dose-dependent reduction in cell growth against SMA-560, SJ-G2, SW480, MCF-7 and A2780 cultures, as being the most sensitive among a panel of other cancer cell lines (GI50=4.0 - 37uM). It was further shown to be 6-fold more active (IC50=5.0uM) than dynamin mediated receptor mediated endocytosis (RME) in U2OS cells, and 15-fold more active (IC50=1.3uM) than Dynasore in another Dynamin I GTPase activity assay. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Dynamin inhibitory peptide | Has been found to be a peptide inhibitor of the GTPase dynamin and competitively blocks binding of dynamin to amphiphysin thus prevents endocytosis when administered intracellularly. Synonyms: Dynamin inhibitory peptide; 251634-21-6; L-Proline, L-glutaminyl-L-valyl-L-prolyl-L-seryl-L-arginyl-L-prolyl-L-asparaginyl-L-arginyl-L-alanyl-; QVPSRPNRAP; HY-P1083; AKOS024456770; MS-31983; CS-0027626. Grades: >98%. CAS No. 251634-21-6. Molecular formula: C47H80N18O14. Mole weight: 1121.26. | |
| Dynamin inhibitory peptide, myristoylated | An inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis. Synonyms: AKOS024456771; Dynamin inhibitory peptide,myristoylated; PD079118; S-251634-22-7. Grades: >99%. CAS No. 251634-22-7. Molecular formula: C61H107N19O14. Mole weight: 1330.64. | |
| Dynasore | Dynamin GTPase inhibitor. Endocytosis inhibitor. Viral infection inhibitor. Destabilizes actin filaments. Inhibits entry of Trypanosoma into macrophages. Group: Biochemicals. Grades: Highly Purified. CAS No. 304448-55-3. Pack Sizes: 5mg, 25mg. Molecular Formula: C18H14N2O4. 0.5H2O. US Biological Life Sciences. | Worldwide |
| Dynasore | Dynasore is a cell-permeable and noncompetitive inhibitor of the GTPase activity of dynamin with IC50 value of 15 μM. Synonyms: Dynasore. Grades: >98%. CAS No. 304448-55-3. Molecular formula: C18H14N2O4. Mole weight: 322.31. | |
| EDA-ATPγS - ATTO-580Q | EDA-ATPγS - ATTO-580Q, a fluorescent labeling reagent employed in biomedical research, facilitates a study of diverse cellular processes with ATPγS analogs. This reagent plays a vital role in characterizing vesicular transportation processes, visualizing Rho GTPase activity, as well as identifying actin-binding proteins. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-adenosine-5'-(γ-thio)-triphosphate, labeled with ATTO 580Q, Triethylammonium salt. Grades: ≥ 90 % by HPLC, contains approx. 5 % EDA-ADP-dye. Molecular formula: C13H22N7O13P3S - ATTO 580Q (free acid). Mole weight: 1285.33 (free acid). | |
| EDA-GDP - ATTO-488 | EDA-GDP - ATTO-488 is a fluorescent labeling compound unlocking a myriad of imaging and detection possibilities across diverse applications, including the ever-evolving domains of cell biology and molecular biology research. Specifically engineered to label GTP-binding proteins and proficiently probe GTPase activity, EDA-GDP - ATTO-488 is used for comprehending intricate signaling pathways in various debilitating diseases. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-Guanosine-5'-diphosphate, labeled with ATTO 488, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C38H42N10O21P2S2(free acid). Mole weight: 1100.87 (free acid). | |
| EDA-GDP - ATTO-532 | EDA-GDP - ATTO-532, a common fluorescent probe utilized in research on Rho GTPase signaling pathways, proves useful in monitoring small GTPases, specifically Rac1, Cdc42, and RhoA. The said GTPases govern cellular processes, including cell migration, division, and cytoskeleton organization. EDA-GDP - ATTO-532's broad applications also extend to investigating various diseases that relate to Rho GTPase dysregulation, namely cancer, neurological disorders, and developmental abnormalities. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-Guanosine-5'-diphosphate, labeled with ATTO 532, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C42H49N10O21P2S2(free acid). Mole weight: 1155.97 (free acid). | |
| EDA-GDP - BDP-FL | EDA-GDP - BDP-FL, a fluorescent probe, is widely employed in scrutinizing GTPase activity and signaling pathways. By monitoring small GTPases and their interactions with proteins, it serves as a reliable tool for investigating various pathophysiological processes, including cancer, where small GTPases have acquired a prominent role in growth and metastasis. Synonyms: also known as BODIPY® FL-GDP;2'/3'-O-(2-Aminoethyl-carbamoyl)-Guanosine-5'-diphosphate, labeled with BODIPY® FL, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C27H34BF2N9O13P2(free acid). Mole weight: 803.37 (free acid). | |
| EDA-GDP - Cy5 | EDA-GDP - Cy5, an illuminating fluorescent labeling reagent, magnifies the intricacies of cell biology and biomedicine with its remarkable affinity for proteins and protein-protein interactions. This reagent sheds light on the activity of GTPase enzymes implicated in diverse diseases, including cancer. As a luminous ally in biostudies, it dispels the shadows of mystery from the cellular world. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-Guanosine-5'-diphosphate, labeled with Cy5, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C46H59N9O19P2S2(free acid). Mole weight: 1168.09 (free acid). | |
| EDA-GppNHp (EDA-GMPPNP) - ATTO-488 | EDA-GppNHp (EDA-GMPPNP) - ATTO-488, a fluorescently labeled nucleotide analog, is a vital tool for the study of nucleotide-binding proteins and their interactions. Its utility extends to fluorescence resonance energy transfer (FRET) experiments, where it plays an essential role in monitoring protein conformational changes linked with the actions of nucleotide binding and hydrolysis. EDA-GppNHp has also proven to be useful in the investigation of ATPase and GTPase activities, and in the development of assays for G protein-coupled receptor (GPCR) signaling. Its multifaceted nature offers nuanced insights into complex protein interactions, positioning it as a favorite among researchers invested in these areas. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-Guanosine-5'-[(β,γ)-imido] triphosphate, labeled with ATTO 488, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C38H44N11O23P3S2(free acid). Mole weight: 1179.87 (free acid). | |
| EDA-GTP - 5/6-TAMRA | EDA-GTP - 5/6-TAMRA is a highly utilized fluorescent tracer that embodies immense potential in various biochemical assays. Notably, its application is instrumental in exploring molecular interactions involving GTP-binding proteins, and it is a tracer of choice for GTP hydrolysis assays. Besides, it has revolutionized the monitoring of small GTPases activation and drug discovery, where it effectively assesses the impact of drugs on GTPase activity. The compound's multipurpose functionality and exceptional efficiency render it an invaluable asset in scientific research. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-Guanosine-5'-triphosphate, labeled with 5/6-TAMRA, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C38H42N9O19P3(free acid). Mole weight: 1021.72 (free acid). | |
| EDA-GTP - 6-JOE | EDA-GTP - 6-JOE is a fluorescently labeled nucleotide analog used for investigating GTPase activity in biomedical research. It can be used to monitor GTP hydrolysis activity of small GTPases such as Rab proteins and is commonly used in drug discovery studies for treatments related to oncology and neurodegenerative diseases. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-Guanosine-5'-triphosphate, labeled with 6-JOE, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C36H34Cl2N7O23P3(free acid). Mole weight: 1095.03 (free acid). | |
| EDA-GTP - 6-ROX | EDA-GTP - 6-ROX is a fluorescent probe widely used in biomedical field for the detection of GTPase activity. It can be utilized to study various aspects of GTPase-mediated cellular processes and signaling pathways. This highly sensitive dye enables accurate visualization and quantification of GTPase activity, making it valuable for drug discovery and understanding diseases associated with aberrant GTPase function. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-Guanosine-5'-triphosphate, labeled with 6-ROX, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C46H50N9O19P3(free acid). Mole weight: 1125.87 (free acid). | |
| EDA-GTP - ATTO-465 | EDA-GTP - ATTO-465 is a fluorescently tagged purine analogue used in biomedicine research to study purinergic signaling pathways and GTPases. EDA-GTP - ATTO-465 can be used in studies involving drugs targeting G protein-coupled receptors or diseases involving abnormal GPCR signaling such as cancer, cardiovascular and neuropsychiatric disorders. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-Guanosine-5'-triphosphate, labeled with ATTO 465, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C30H37N10O16P3(free acid). Mole weight: 886.59 (free acid). | |
| EDA-GTP - ATTO-488 | EDA-GTP - ATTO-488 is a fluorescent labeled derivative of guanosine triphosphate (GTP) often used in fluorescence microscopy to study GTPase activity in vitro and in vivo. It can also be utilized as a biochemical probe to investigate binding affinity, hydrolysis kinetics, and exchange rates of GTPases in various cell signaling pathways. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-Guanosine-5'-triphosphate, labeled with ATTO 488, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C38H43N10O24P3S2(free acid). Mole weight: 1180.11 (free acid). | |
| EDA-GTP - ATTO-540Q | EDA-GTP - ATTO-540Q is a fluorescently labeled guanosine triphosphate analog commonly used for studying GTPases involved in various cellular processes such as cancer and neurological disorders. Its high sensitivity and stability make it an ideal probe for live-cell imaging and protein-protein interaction analysis. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-Guanosine-5'-triphosphate, labeled with ATTO 540Q, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C13H22N7O15P3- ATTO 540Q (free acid). Mole weight: 1149.27 (free acid). | |
| EDA-GTP - ATTO-550 | EDA-GTP - ATTO-550 is a fluorescent dye used in biomedical research to label and visualize small GTPases. It enables the measurement of GTP hydrolysis rates and identifies which GTPases are activated in certain diseases such as cancer. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-Guanosine-5'-triphosphate, labeled with ATTO 550, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C13H22N7O15P3- ATTO 550 (free acid). Mole weight: 1184.27 (free acid). | |
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