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| Product | Description | |
|---|---|---|
| guanylate cyclase | Also acts on ITP and dGTP. Group: Enzymes. Synonyms: guanylyl cyclase; guanyl cyclase; GTP diphosphate-lyase (cyclizing). Enzyme Commission Number: EC 4.6.1.2. CAS No. 9054-75-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5355; guanylate cyclase; EC 4.6.1.2; 9054-75-5; guanylyl cyclase; guanyl cyclase; GTP diphosphate-lyase (cyclizing). Cat No: EXWM-5355. |  |
| Guanylate cyclase-IN-1 | Guanylate cyclase-IN-1 (Example 46) is a guanylate cyclase inhibitor that can be used for cardiovascular diseases research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1361569-23-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-W021162. |  |
| diguanylate cyclase | A GGDEF-domain-containing protein that requires Mg2+ or Mn2+ for activity. The enzyme can be activated by BeF3, a phosphoryl mimic, which results in dimerization. Dimerization is required but is not sufficient for diguanylate-cyclase activity. Cyclic di-3',5'-guanylate is an intracellular signalling molecule that controls motility and adhesion in bacterial cells. It was first identified as having a positive allosteric effect on EC 2.4.1.12, cellulose synthase (UDP-forming). Group: Enzymes. Synonyms: DGC; PleD. Enzyme Commission Number: EC 2.7.7.65. CAS No. 146316-82-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3276; diguanylate cyclase; EC 2.7.7.65; 146316-82-7; DGC; PleD. Cat No: EXWM-3276. | |
| 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile | 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile is used in various studies of stimulators of soluble guanylate cyclase. Group: Biochemicals. Grades: Highly Purified. CAS No. 256376-65-5. Pack Sizes: 100mg, 250mg. Molecular Formula: C14H9FN4. US Biological Life Sciences. |  Worldwide |
| 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide Hydrochloride | 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide Hydrochloride is a key intermediate in the synthesis of Riociguat, a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension. Group: Biochemicals. Grades: Highly Purified. CAS No. 256499-19-1. Pack Sizes: 250mg, 500mg. Molecular Formula: C14H13ClFN5. US Biological Life Sciences. | Worldwide |
| 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylic Acid Ethyl Ester | 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylic Acid Ethyl Ester is used in various studies of stimulators of soluble guanylate cyclase. Group: Biochemicals. Grades: Highly Purified. CAS No. 256376-59-7. Pack Sizes: 5mg, 25mg. Molecular Formula: C16H14FN3O2. US Biological Life Sciences. | Worldwide |
| 1-?[ (3-Fluorophenyl) ?methyl]?-1H-?pyrazolo[3, ?4-?b]?pyridine-?3-?carboximidamide | 1-?[ (3-Fluorophenyl) ?methyl]?-1H-?pyrazolo[3, ?4-?b]?pyridine-?3-?carboximidamide is a useful reactant in preparation of pyrrolopyrimidinone derivatives as soluble guanylate cyclase activators. Group: Biochemicals. Grades: Highly Purified. CAS No. 2101651-50-5. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C14H12FN5, Molecular Weight: 269.279999999999. US Biological Life Sciences. | Worldwide |
| 2- (1- (2-Fluorobenzyl) -1H-pyrazolo[3, 4-b]pyridin-3-yl) -5- (phenyldiazenyl) pyrimidine-4, 6-diamine | 2- (1- (2-Fluorobenzyl) -1H-pyrazolo[3, 4-b]pyridin-3-yl) -5- (phenyldiazenyl) pyrimidine-4, 6-diamine is a metabolite of stimulators of soluble guanylate cyclase for the treatment of pulmonary hypertension. Group: Biochemicals. Grades: Highly Purified. CAS No. 428854-23-3. Pack Sizes: 1g, 2.5g. Molecular Formula: C23H18FN9, Molecular Weight: 439.45. US Biological Life Sciences. | Worldwide |
| 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine | 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine is a metabolite of stimulators of soluble guanylate cyclase for the treatment of pulmonary hypertension. Group: Biochemicals. Grades: Highly Purified. CAS No. 428854-24-4. Pack Sizes: 50mg, 100mg. Molecular Formula: C17H15FN8. US Biological Life Sciences. | Worldwide |
| 2-Cl-ATP | 2-Cl-ATP is an agonist of P2Y purinoceptor that inhibits soluble guanylate cyclase. Synonyms: 2- Chloroadenosine- 5'- triphosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 49564-60-5. Molecular formula: C10H15ClN5O13P3 (free acid). Mole weight: 541.6 (free acid). |  |
| 2-MeS-ATP | 2-MeS-ATP is an agonist of P2Y purinoceptors that inhibits soluble guanylate cyclase. Uses: Purinergic agonists. Synonyms: 2- Methylthioadenosine- 5'- O- triphosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 43170-89-4. Molecular formula: C11H18N5O13P3S (free acid). Mole weight: 553.3 (free acid). | |
| 3-Cyano-2-oxo-propionic Acid Ethyl Ester Sodium Salt | 3-Cyano-2-oxo-propionic Acid Ethyl Ester Sodium Salt is used in the preparation of stimulators of soluble guanylate cyclase. Group: Biochemicals. Grades: Highly Purified. CAS No. 53544-13-1. Pack Sizes: 500mg, 1g. Molecular Formula: C6H6NNaO3, Molecular Weight: 163.11. US Biological Life Sciences. | Worldwide |
| 4-Phenyl-3-furoxancarbonitrile (Furoxan, RVC-589) | Able to activate the soluble guanylate cyclase by releasing Nitric Oxide under the action of thiol cofactors. Also inhibits platelet aggregation. Group: Biochemicals. Alternative Names: Furoxan, RVC-589. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 6-Anilino-5,8-quinolinedione (LY 83583) | Inhibits nitric-oxide-induced activation of soluble guanylate cyclase (IC50=2µM) in a dose-dependent and reversible manner. It blocks acetylcholine induced vasorelaxation. Also an inhibitor of antigen-induced leukotriene release. Group: Biochemicals. Alternative Names: LY 83583. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-740 | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-740, a fluorescent probe, is a valuable tool in biomedical research for investigating the function of guanylyl cyclases and soluble guanylate cyclases. Notably, this versatile probe can be used to study the mechanisms underlying cardiovascular diseases and neuronal disorders, thereby offering the potential for significant scientific breakthroughs and medical advancements. Its reliability and efficacy make it a highly sought-after compound for researchers across diverse fields. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 740, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H26N7O7P - ATTO 740 (free acid). Mole weight: 908.39 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - DY-776 | DY-776, a potent and selective agonist of soluble guanylate cyclase (sGC), stands as a key target for treatment of pulmonary hypertension and other cardiovascular diseases. Operating through its heme-containing domain, the DY-776 compound effortlessly binds, exhibiting increases in cyclic guanosine monophosphate (cGMP) concentrations in smooth muscle cells facilitating the enhanced vasodilation and an improved blood flow. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with DY 776. Grades: ≥ 95% by HPLC. Molecular formula: C60H72N9O15PS2 (free acid). Mole weight: 1254.37 (free acid). | |
| A-350619 hydrochloride | A-350619 hydrochloride is a soluble guanylate cyclase ( sGC ) activator. A-350619 hydrochloride can be used in the study of erectile dysfunction [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1217201-17-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-107548. | |
| Ac-Linaclotide | Ac-Linaclotide is an impurity of Linaclotide, which is a peptide agonist of guanylate cyclase 2C used for the treatment of abdominal pain in patients with irritable bowel syndrome (IBS) associated with constipation. Synonyms: Ac-L-cysteinyl-L-cysteinyl-L-alpha-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-aspargenyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonyl-glycyl-L-cysteinyl-L-tyrosine (1-6),(2-10),(5-13)-tris(disulfide); Ac-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH (disulfide bridges between 1-6, 2-10 and 5-13 Cysteines); N-Acetyl-linaclotide; L-Tyrosine, N-acetyl-L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (1?6),(2?10),(5?13)-tris(disulfide). CAS No. 1422389-17-0. Molecular formula: C61H81N15O22S6. Mole weight: 1568.76. | |
| Acylated Linaclotide | Linaclotide is a 14 amino acid peptide that is a guanylate cyclase C agonist.It is suitable for the treatment of adult CC and IBS-C. Molecular formula: C61H81N15O22S6. Mole weight: 1568.76. | |
| Asp(7)-Linaclotide | Asp(7)-Linaclotde is an impurity of Linaclotide, which is a peptide agonist of guanylate cyclase 2C used for the treatment of abdominal pain in patients with irritable bowel syndrome (IBS) associated with constipation. Synonyms: L-cysteinyl-L-cysteinyl-L-alpha-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-α-aspartyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonyl-glycyl-L-cysteinyl-L-tyrosine (1-6),(2-10),(5-13)-tris(disulfide); H-Cys-Cys-Glu-Tyr-Cys-Cys-Asp-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH (Disulfide bridge: Cys1-Cys6, Cys2-Cys10, Cys5-Cys13); [7-Asp]-linaclotide; L-Tyrosine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-α-aspartyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (1?6),(2?10),(5?13)-tris(disulfide). CAS No. 1207977-38-5. Molecular formula: C59H78N14O22S6. Mole weight: 1527.71. | |
| Aspartyl Linaclotide | Aspartyl Linaclotide is a 14 amino acid peptide that is a guanylate cyclase C agonist.It is suitable for the treatment of adult CC and IBS-C. Molecular formula: C59H78N14O22S6. Mole weight: 1527.71. | |
| Ataciguat | Ataciguat, formerly referred to as HMR-1766, a novel anthranilic acid derivative, is a potent guanylate cyclase activator. Ataciguat has potential to treat diseases associated with increased vascular tone combined with enhanced ROS production. Uses: Ataciguat, formerly referred to as hmr-1766, a novel anthranilic acid derivative, belongs to a new structural class of sgc activators capable of activating the oxidized form of sgc. ataciguat has been shown to improve endothelial function and to reduce p. Synonyms: HMR-1766; HMR 1766; HMR1766; Ataciguat; 5-Chloro-2-[[ (5-chloro-2-thienyl) sulfonyl]amino]-N-[4- (4-morpholinylsulfonyl) phenyl]benzamide; Ataciguat; HMR 1766. Grades: >98%. CAS No. 254877-67-3. Molecular formula: C21H19Cl2N3O6S3. Mole weight: 576.5. | |
| Atrial natriuretic factor (1-28) (human, porcine) | Atrial natriuretic factor (1-28) (human, porcine) is a 28 amino acid peptide corresponding to the rat protein sequence. It is an endogenous peptide synthesized in myoendocrine cells of the heart from which it is released into the circulation. It has effects on the renal and cardiovascular systems that decrease vasoconstriction, increase sodium excretion and inhibit renin secretion. It decreases plasma renin activity and cAMP levels in anesthetized rats and increases cGMP levels at 8 μg/kg. It also inhibits arginine vasopressin-induced increase in mean arterial blood pressure in spontaneously hypertensive and control rats when administered intracerebroventricularly at a dose of 150 ng. It produces diuretic, natriuretic and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure regulation. Synonyms: ANF 1-28; hANF; Atrial Natriuretic Peptide human. CAS No. 91917-63-4. Molecular formula: C127H205N45O39S3. Mole weight: 3080.46. | |
| BAY 41-2272 | BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator. Synonyms: BAY 41-2272; BAY-41-2272; BAY41-2272; BAY412272; BAY-412272; BAY 412272. Grades: 98%. CAS No. 256376-24-6. Molecular formula: C20H17FN6. Mole weight: 360.39. | |
| BAY 41-2272 | BAY 41-2272 is an orally active and soluble guanylate cyclases ( sGC ) activator, which increases sGC activity by 400-fold in synergy with NO. BAY 41-2272 potently unloaded the heart, increased cardiac output, thus can be used for cardiovascular diseases research [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 256376-24-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12376. | |
| Cinaciguat | An experimental drug as an an activator of sGC in an NO-independent manner (Kd = 3.2 nM). Uses: Soluble guanylate cyclase (sgc) activators. Synonyms: BAY 58-2667; BAY 582667; BAY-58-2667; BAY582667 4-((4-carboxybutyl)(2-((4-phenethylbenzol) oxy)phenethyl)amino)methyl(benzoic) acid. Grades: ≥98.0%. CAS No. 329773-35-5. Molecular formula: C36H39NO5. Mole weight: 565.70. | |
| Cinaciguat | Cinaciguat is an activator of guanylate cyclase (sGC) , and used for acute decompensated heart failure. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY 58-2667. CAS No. 329773-35-5. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14181. | |
| Cinaciguat hydrochloride | Cinaciguat hydrochloride is a potent soluble guanylate cyclase ( GC ) activator with EC 50 of 15 nM in platelets. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY 58-2667 hydrochloride. CAS No. 646995-35-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14181A. | |
| CTPαS | CTPαS, a molecule activator of soluble guanylate cyclase (sGC), is vying for a preeminent position in the study of nitric oxide signaling pathway. With its therapeutic potential locked and loaded, CTPαS is turning heads in the scientific community, demonstrating potential efficacy in addressing cardiovascular diseases such as hypertension and pulmonary arterial hypertension, as well as a wide range of central nervous system conditions, including neurodegenerative diseases and pain management alike. Synonyms: Cytidine-5'-(α-thio)-triphosphate, Sodium salt (1 : 1 Mixture of Rp and Sp isomers). Grades: ≥ 95% by HPLC. Molecular formula: C9H16N3O13P3S (free acid). Mole weight: 499.21 (free acid). | |
| cUMP | cUMP is an analog of cyclic uridine monophosphate, showcasing its proficiency as a robust stimulator of soluble guanylate cyclase (sGC). With its implementation in biomedical research, an extensive exploration of sGC's involvement in diverse ailments such as cancer, cardiovascular disorders and neurodegenerative diseases is facilitated. Synonyms: Uridine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 56632-58-7. Molecular formula: C9H10N2O8P · Na. Mole weight: 328.2. | |
| Cyclic GMP sodium salt | Cyclic GMP or cGMP is a second messenger and it is biosynthesized from GTP by guanylate cyclases. Nitric oxide and natriuretic peptides arw activators of guanylate cyclases. cGMP activates protein kinase G (PKG) and modulates ion channel conductance, with signaling affecting diverse processes including smooth muscle relaxation and proliferation, phototransduction, and energy homeostasis. Synonyms: cGMP; Cyclic guanosine monophosphate; Guanosine 3'5'-cyclic monophosphate; Monosodium-GMP. Grades: ≥98%. CAS No. 40732-48-7. Molecular formula: C10H11N5O7P·Na. Mole weight: 367.2. | |
| cyclic-guanylate-specific phosphodiesterase | Requires Mg2+ or Mn2+ for activity and is inhibited by Ca2+ and Zn2+. Contains a heme unit. This enzyme linearizes cyclic di-3,5-guanylate, the product of EC 2.7.7.65, diguanylate cyclase and an allosteric activator of EC 2.4.1.12, cellulose synthase (UDP-forming), rendering it inactive. It is the balance between these two enzymes that determines the cellular level of c-di-GMP. Group: Enzymes. Synonyms: cyclic bis(3?5')diguanylate phosphodiesterase; c-di-GMP-specific phosphodiesterase; c-di-GMP phosphodiesterase; phosphodiesterase (misleading); phosphodiesterase A1; PDEA1; VieA. Enzyme Commission Number: EC 3.1.4.52. CAS No. 338732-46-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3735; cyclic-guanylate-specific phosphodiesterase; EC 3.1.4.52; 338732-46-0; cyclic bis(3?5')diguanylate phosphodiesterase; c-di-GMP-specific phosphodiesterase; c-di-GMP phosphodiesterase; phosphodiesterase (misleading); phosphodiesterase A1; PDEA1; VieA. Cat No: EXWM-3735. | |
| Cys(1)-IMD-Linaclotide | Cys(1)-IMD-Linaclotide is an impurity of Linaclotide, which is a peptide agonist of guanylate cyclase 2C used for the treatment of abdominal pain in patients with irritable bowel syndrome (IBS) associated with constipation. Synonyms: (5-thio-4-imidazole-3-yl)-L-cysteinyl-L-cysteinyl-L-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonyl-glycyl-L-cysteinyl-L-tyrosine (1-6),(2-10),(5-13)-tris(disulfide); IMD-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH (disulfide bridge between 1-6, 2-10 and 5-13 Cysteines); L-Tyrosine, N-[(2R)-3-mercapto-2-[(4R)-4-(mercaptomethyl)-5-oxo-1-imidazolidinyl]-1-oxopropyl]-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (12?4),(13?8),(3?11)-tris(disulfide). CAS No. 1331835-31-4. Molecular formula: C60H79N15O21S6. Mole weight: 1538.74. | |
| Des-Asn(1)-Plecanatide | Des-Asn(1)-Plecanatide is an impurity of Plecanatide, which is a guanylate cyclase-C (GCC) agonist for the treatment of gastrointestinal disorders, such as chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). Synonyms: H-Asp-Glu-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH (Disulfide bridge: Cys3-Cys11, Cys6-Cys14); L-alpha-aspartyl-L-alpha-glutamyl-L-cysteinyl-L-alpha-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparagyl-L-valyl-L-alanyl-L-cysteinyl-L-threonyl-glycyl-L-cysteinyl-L-leucine (3->11),(6->14)-bis(disulfide); L-Leucine, L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (3?11),(6?14)-bis(disulfide). CAS No. 1092457-59-4. Molecular formula: C61H98N16O24S4. Mole weight: 1567.78. | |
| Des-Tyr(14)-Linaclotide | Des-Tyr(14)-Linaclotide is an impurity of Linaclotide, which is a peptide agonist of guanylate cyclase 2C used for the treatment of abdominal pain in patients with irritable bowel syndrome (IBS) associated with constipation. Synonyms: L-cysteinyl-L-cysteinyl-L-alpha-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparagyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonyl-glycyl-L-cysteine (1->6),(2->10),(5->13)-tris(disulfide); H-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-OH (Disulfide bridge: Cys1-Cys6, Cys2-Cys10, Cys5-Cys13); (3S, 6R, 9S, 15R, 20R, 23S, 26S, 29R, 32R, 37R, 40S, 45aS)-32-amino-40-(2-amino-2-oxoethyl)-26-(2-carboxyethyl)-23-(4-hydroxybenzyl)-9-((R)-1-hydroxyethyl)-3-methyl-1, 4, 7, 10, 13, 22, 25, 28, 31, 38, 41, 47-dodecaoxotetracontahydro-19H-37, 20-(epiminomethano)-6, 29-(methanodithiomethano)pyrrolo[2, 1-s][1, 2, 27, 28]tetrathia[5, 8, 11, 14, 17, 20, 23, 32, 35, 38, 41]undecaazacyclotritetracontine-15-carboxylic acid; Linaclotide metabolite MM 419447; MM 419447; SP 340; L-Cysteine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-, cyclic (1?6),(2?10),(5?13)-tris(disulfide). CAS No. 1092457-78-7. Molecular formula: C50H70N14O19S6. Mole weight: 1363.55. | |
| Indusatumab | Indusatumab is a monoclonal antibody targeting Guanylate cyclase 2C (GUCY2C). Synonyms: 5F9 Monoclonal antibody. CAS No. 1497400-26-6. | |
| Isatin | Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC 50 of 3 μM. Also binds to central benzodiazepine receptors (IC 50 against clonazepam, 123 μM) [1]. Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity [2]. Shows effect on the serotonergic system [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Indoline-2,3-dione. CAS No. 91-56-5. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-Y0265. | |
| IWP-051 | IWP-051 is a soluble guanylate cyclase (sGC) stimulator with EC50 of 290nM. IWP-051 shows >99% plasma protein binding, high permeability, high metabolic stability, and no efflux in a Caco-2 model of intestinal absorption. Synonyms: IWP-051; IWP051; IWP 051; 5-fluoro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidin-4(3H)-one. Grades: 98%. CAS No. 1354041-91-0. Molecular formula: C17H11F2N5O2. Mole weight: 355.30. | |
| Linaclotide | Linaclotide is a peptide agonist of guanylate cyclase 2C that is undergoing clinical trials for use in treating abdominal pain in patients with irritable bowel syndrome (IBS) accompanied by constipation. The drug also has promising outlooks for the treatment of gastroparesis, ulcerative colitis, chronic intestinal pseudo-obstruction (CIPO), and inertia coli as well. Synonyms: Constella; Linzess; L-Tyrosine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (1?6),(2?10),(5?13)-tris(disulfide); L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparagyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonyl-glycyl-L-cysteinyl-L-tyrosine (1->6),(2->10),(5->13)-tris(disulfide); H-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH (Disulfide bridge: Cys1-Cys6, Cys2-Cys10, Cys5-Cys13). Grades: ≥95%. CAS No. 851199-59-2. Molecular formula: C59H79N15O21S6. Mole weight: 1526.74. | |
| Linaclotide | Linaclotide is a peptide agonist of the guanylate cyclase C receptor (Ki = 16.4nM in a radioligand binding assay using mouse intestinal mucosa).1 Luminal exposure to 5ug of linaclotide stimulates fluid secretion and cGMP concentration in jejunal loops isolated from wild-type mice but not guanylate cyclase C receptor null mice. Linaclotide (100ug/kg) increases intestinal transit in wild-type mice. It also reduces the number of phosphorylated ERK-positive dorsal horn neurons in the thoracolumbar spinal cord, a marker of nociceptive signaling, following noxious colorectal distension and mechanical hypersensitivity in a mouse model of TNBS-induced colitis.2 Formulations containing linaclotide have been used for the treatment of constipation and pain associated with irritable bowel syndrome. Group: Biochemicals. Alternative Names: L-Cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-tyrosine Cyclic (1?6),(2?10),(5?13)-Tris(disulfide). Grades: Highly Purified. CAS No. 851199-59-2. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C??H??N??O??S?, Molecular Weight: 1526.74. US Biological Life Sciences. | Worldwide |
| Linaclotide | Linaclotide is a potent and selective guanylate cyclase C agonist; developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation. Uses: Scientific research. Group: Peptides. CAS No. 851199-59-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-17584. | |
| Linaclotide acetate | Linaclotide is an oligo-peptide agonist of guanylate cyclase 2C. It can be used for the treatment in adults of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation. Uses: Constipation; irritable bowel syndrome. Synonyms: L-Tyrosine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (1?6),(2?10),(5?13)-tris(disulfide), acetate (1:1); L-Tyrosine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (1?6),(2?10),(5?13)-tris(disulfide), monoacetate (salt); Linaclotide monoacetate; MM 416775; H-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH.CH3CO2H (Disulfide bridge: Cys1-Cys6, Cys2-Cys10, Cys5-Cys13). Grades: 95%. CAS No. 851199-60-5. Molecular formula: C61H83N15O23S6. Mole weight: 1586.80. | |
| LY83583 | LY83583 is an Msp1 inhibitor, a guanylate cyclase inhibitor and a cGMP modulator. LY83583 inhibits soluble guanylate cyclase in human platelets with an IC50 of 2 μM. LY83583 also inhibits leukotriene synthesis in guinea pig lung and rat peritoneal cells with an IC50 of 1.8 μM, and is a noncompetitive inhibitor of glutathione reductase in bovine intestinal mucosa with a Ki of 3 μM. Uses: Enzyme inhibitors. Synonyms: 6-Anilino-5,8-quinolinedione; 6-(Phenylamino)quinoline-5,8-dione; 6-(Phenylamino)-5,8-quinolinedione; 6-Anilinoquinoline-5,8-quinone; 6-(phenylamino)quinoline-5,8-dione. Grades: ≥95%. CAS No. 91300-60-6. Molecular formula: C15H10N2O2. Mole weight: 250.25. | |
| LY 83583 (LY83583, 6-Anilino-5,8-quinolinequinone) | A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC50=2uM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca2+ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells. Also inhibits neutrophil chemotaxis induced by NO donors. Group: Biochemicals. Grades: Highly Purified. CAS No. 91300-60-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Methylene Blue | Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC) , monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue is a Tau aggregation inhibitor. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation [1] [2] [3]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Basic Blue 9; CI-52015; Methylthioninium chloride. CAS No. 61-73-4. Pack Sizes: 100 mg; 500 mg. Product ID: HY-14536. | |
| Methylene blue hydrate | Methylene blue (Basic Blue 9) hydrate is a guanylyl cyclase (sGC) , monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue hydrate through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue hydrate is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue hydrate is a Tau aggregation inhibitor. Methylene blue hydrate reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Basic Blue 9 hydrate; CI-52015 hydrate; Methylthioninium chloride hydrate. CAS No. 122965-43-9. Pack Sizes: 1 g; 5 g. Product ID: HY-D0958. | |
| Methylene blue hydrate | Methylene blue (Basic Blue 9) hydrate is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue hydrate through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue hydrate is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue hydrate is a Tau aggregation inhibitor. Methylene blue hydrate reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation. Group: Inhibitors. CAS No. 122965-43-9. Molecular formula: C16H18ClN3S.xH2O. Mole weight: 337.87. Appearance: Solid. Canonical SMILES: CN (C1=CC2=[S+]C3=C (C=CC (N (C)C)=C3)N=C2C=C1)C. [x]. [Cl-]. O. Catalog: ACM122965439. |  |
| MM-419447 (Linaclotide Metabolite) Trifluoroacetic acid | MM-419447 (Linaclotide Metabolite) Trifluoroacetic acid is a metabolite of Linaclotide, which is a peptide agonist of guanylate cyclase 2C used to treat abdominal pain associated with constipation in patients with irritable bowel syndrome (IBS). Synonyms: L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteine trifluoroacetic acid; L-Cysteine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-, trifluoroacetic acid (1:x); H-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-OH.TFA. Grades: 97%. Molecular formula: C50H76N14O19S6.xC2HF3O2. Mole weight: 1369.61 (free base). | |
| Nelociguat | Nelociguat is a soluble guanylate cyclase stimulator (sGC stimulator), which is a key enzyme in the nitric oxide (NO) signalling pathway. It is used for the treatment of pulmonary hypertension. It promotes vasodilation and inhibits smooth muscle proliferation, leukocyte recruitment, platelet aggregation and vascular remodelling through a number of downstream mechanisms. It was also used for erectile dysfunction and heart failure. It was developed by Bayer and was in clinic phase 2 trials with no progress. Uses: Nelociguat is used for the treatment of pulmonary hypertension. it was also used for erectile dysfunction and heart failure. Synonyms: BAY60-4552; Methyl [4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]carbamate; Carbamic acid, N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-, methyl ester; N-Desmethyl Riociguat. Grades: 98%. CAS No. 625115-52-8. Molecular formula: C19H17FN8O2. Mole weight: 408.39. | |
| Olinciguat | Olinciguat is an oral guanylate cyclase (sGC) stimulant. Synonyms: IW-1701; PD5F4ZXD21; IW1701. Grades: ≥98% by HPLC. CAS No. 1628732-62-6. Molecular formula: C21H16F5N7O3. Mole weight: 509.4. | |
| Olinciguat | Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IW-1701. CAS No. 1628732-62-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-109066. | |
| Plecanatide | Plecanatide, also called Trulance, a synthetic analogue of uroguanylin, is a guanylate cyclase-C (GCC) agonist being developed by Synergy Pharmaceuticals for the treatment of gastrointestinal disorders, such as chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). In January 2017, an oral formulation of plecanatide received its first global approval in the USA for the treatment of adult patients with CIC. Besides, Plecanatide is undergoing phase III investigation in IBS-C. It had also undergone preclinical investigations in inflammatory bowel disease (IBD) and ulcerative colitis; however, development in these indications has been discontinued. Uses: Guanylyl cyclase c agonists; gastrointestinal agents. Synonyms: L-Leucine, L-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4?12)?,?(7?15)?-bis(disulfide); 105: PN: WO2012037380 SEQID: 105 claimed protein; 1: PN: US20100152118 SEQID: 1 claimed protein; 1: PN: WO2008151257 SEQID: 1 claimed protein; 1: PN: WO2010065751 SEQID: 1 claimed protein; 1: PN: WO2011069038 SEQID: 1 claimed sequence; 1: PN: WO2012037380 SEQID: 1 claimed protein; 1: PN: WO2014131024 SEQID: 1 claimed protein; 1: PN: WO2015054500 SEQID: 1 claimed protein; 1: PN: WO2015054649 SEQID: 1 claimed protein; 20: PN: WO02078683 SEQID: 20 claimed protein; 78: PN: WO2010065751 SEQID: 105 claimed protein; 7: PN: WO2015054500 SEQID: 105 claimed protein; 8: PN: WO2015054500 SEQID: 106 claimed protein; 9: PN: WO2015054500 SEQID: 107 claimed protein; SP 304; Trulance. CAS No. 467426-54-6. Molecular formula: C65H104N18O26S4. Mole weight: 1681.89. | |
| Plecanatide | Plecanatide, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide activates GC-C receptors to stimulate cGMP synthesis with an EC 50 of 190 nM in T84 cells assay. Plecanatide shows anti-inflammatory activity in models of murine colitis [1] [2] [3]. Uses: Scientific research. Group: Peptides. CAS No. 467426-54-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-108741. | |
| Plecanatide acetate | Plecanatide acetate, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide acetate activates GC-C receptors to stimulate cGMP synthesis with an EC 50 of 190 nM in T84 cells assay. Plecanatide acetate can be used for the research of chronic idiopathic constipation, and it also shows anti-inflammatory activity in models of murine colitis [1] [2] [3]. Uses: Scientific research. Group: Peptides. CAS No. 1075732-84-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-108741A. | |
| Praliciguat | Praliciguat is a soluble guanylate cyclase stimulator, which can enhance NO signal transduction and act as a vasodilator. Synonyms: IW-1973. Grades: ≥98% by HPLC. CAS No. 1628730-49-3. Molecular formula: C21H14F8N6O2. Mole weight: 534.4. | |
| Praliciguat | Praliciguat (IW-1973) is a potent and orally active soluble guanylate cyclase stimulator, enhances NO signaling, acts as a vasodilator. Praliciguat (IW-1973) stimulates sGC in HEK-293 cells with an EC 50 of 197 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IW-1973. CAS No. 1628730-49-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109039. | |
| Prepro-Atrial Natriuretic Factor (26-55) (human) | Prepro-Atrial Natriuretic Factor (26-55) (human) is a polypeptide that increases renal cortical and medullary cyclic GMP levels. Prepro-Atrial Natriuretic Factor (26-55) (human) increases renal guanylate cyclase activity [1]. Uses: Scientific research. Group: Peptides. CAS No. 112160-82-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4811. | |
| Riociguat | Riociguat is an oral stimulator of soluble guanylate cyclase ( sGC ) used in the treatment of pulmonary hypertension. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY 632521. CAS No. 625115-55-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14779. | |
| Runcaciguat | Runcaciguat is an orally active stimulator of soluble guanylate cyclase , and is used in the research of cardiovascular and renal diseases combined with selective partial adenosine A1 receptor agonists [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY 1101042. CAS No. 1402936-61-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109136. | |
| Uroguanylin | Uroguanylin belongs to the guanylin family of cyclic guanosine monophosphate (cGMP) regulatory peptides. Uroguanylin activates the guanylate cyclase-C/cyclic guanosine monophosphate pathway to induce analgesic effects in colonic hypersensitive animal models, revealing a new approach for the treatment of abdominal pain. Synonyms: Uroguanylin Topoisomer A (human); UGN Topoisomer A (human); H-Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH (Disulfide bridge: Cys4-Cys12, Cys7-Cys15); UGN (human); L-asparagyl-L-alpha-aspartyl-L-alpha-aspartyl-L-cysteinyl-L-alpha-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparagyl-L-valyl-L-alanyl-L-cysteinyl-L-threonyl-glycyl-L-cysteinyl-L-leucine (4->12),(7->15)-bis(disulfide); L-Asparaginyl-L-α -aspartyl-N-{(1R, 4S, 7S, 10S, 13S, 16R, 19S, 22S, 25R, 32S, 38R)-10-(2-amino-2-oxoethyl)-22-(2-carboxyethyl)-38-{[(1S)-1-carboxy-3-methylbutyl]carbamoyl}-32-[(1R)-1-hydroxyethyl]-19-isobutyl-7, 13-diisopropyl-4-methyl-3, 6, 9, 12, 15, 18, 21, 24, 30, 33, 36-undecaoxo-27, 28, 40, 41-tetrathia-2, 5, 8, 11, 14, 17, 20, 23, 31, 34, 37-undecaazabicyclo[14. 13. 13]dotetracont-25-yl}-L-α -asparagine. Grades: ≥90% by HPLC. CAS No. 154525-25-4. Molecular formula: C64H102N18O26S4. Mole weight: 1667.86. | |
| Uroguanylin Topoisomer B (human) | Uroguanylin is a short peptide containing two disulfide bonds that can form interconversion topological isomers with the same disulfide connectivity. In the case of uroguanylin (UGN), both are relatively stable, separable, and slow to transform into each other. Different topoisomers have different biological activities: UGN A topomer can effectively activate the guanylate cyclase C receptor, mainly found in the intestine. The B topomer is a very weak agonist of this receptor. UGN B has strong natriuretic activity in the kidney. Synonyms: UGN Topoisomer B (human); H-Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH (Disulfide bridge: Cys4-Cys12, Cys7-Cys15). Grades: ≥95%. Molecular formula: C64H102N18O26S4. Mole weight: 1667.88. | |
| Vericiguat | Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase stimulator. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY1021189. CAS No. 1350653-20-1. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16774. | |
| Vericiguat | Vericiguat is a potent guanylate cyclase stimulant under the development of Bayer HealthCare Pharmaceuticals. Direct stimulation of guanylate cyclase is emerging as a potential new approach for the treatment of renal disorders. In Aug 2016, Bayer in collaboration with Merck completed phase-I clinical trials in Coronary artery disease (In adults, In the elderly) in Germany. In Sep 2016, Phase-III clinical trials in Chronic heart failure in Germany, Hungary and Spain was on-going. Uses: Chronic heart failure; coronary artery disease. Synonyms: BAY1021189; BAY 1021189; BAY-1021189; BAY10-21189; BAY-10-21189; BAY 10-21189; methyl (4,6-diamino-2-(5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate. Grades: 98%. CAS No. 1350653-20-1. Molecular formula: C19H16F2N8O2. Mole weight: 426.39. | |
| 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one | 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one inhibits neurite outgrowth and causes neurite retraction in PC12 cells independently of soluble guanylyl cyclase. Group: Biochemicals. Alternative Names: ODQ. Grades: Highly Purified. CAS No. 41443-28-1. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| 2-Cyclopropylcarbonyl-3-dimethylaminoacrylic Acid Methyl Ester | 2-Cyclopropylcarbonyl-3-dimethylaminoacrylic Acid Methyl Ester is an intermediate in the preparation of soluble guanylyl cyclase activators. Group: Biochemicals. Alternative Names: α -[ (Dimethylamino) methylene]- β-oxo-cyclopropanepropanoic Acid Methyl Ester;Methyl 2- (Cyclopropylcarbonyl) -3- (dimethylamino) acrylate; Methyl 2-(Cyclopropylcarbonyl)-3-(dimethylamino)prop-2-enoate. Grades: Highly Purified. CAS No. 340774-26-7. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-390 | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-390, a luminescent marker, offers researchers a viable tool to evaluate cyclic nucleotide signaling pathways. It furnishes a mechanism to assay guanylyl cyclase action, as well as drug responsiveness. Moreover, its application has the potential for wider clinical utilization including drug delivery and cancer diagnosis. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 390, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C36H49N8O10P (free acid). Mole weight: 784.80 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-612Q | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-612Q, a fluorescent probe, designed to assist biomedical research in investigating guanylyl cyclase enzyme activity and cGMP-related signaling pathways, as well as studying the pathogenesis of cardiovascular diseases and cancer. The intricacies of this product are profound whilst remaining highly practical, offering a truly unique insight into its potential. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 612Q, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H24N7O7P - ATTO 612Q (free acid). Mole weight: 1131.39 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-647N | 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-647N is a fluorescent probe used for imaging guanylyl cyclase and monitoring cGMP signaling pathways in biological systems. This product can also be utilized in the diagnosis and treatment of disorders related to the activation or inhibition of guanylyl cyclase and cGMP. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 647N, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H26N7O7P - ATTO 647N (free acid). Mole weight: 1086.39 (free acid). | |
| A 350619 hydrochloride | A 350619 hydrochloride is an activator of soluble guanylyl cyclase (sGC) that stimulates basal sGC and synergistically activates sGC in the presence of NO. It is effective for the use of ED treatment. Uses: The treatment of ed. Synonyms: A-350619 hydrochloride; A350619 hydrochloride; A 350619 hydrochloride; 3-[2-[(4-Chlorophenyl)thiophenyl]-N-[4-(dimethylamino)butyl]-2-propenamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 1217201-17-6. Molecular formula: C21H25ClN2OS.HCl. Mole weight: 425.41. | |
| A350619 Hydrochloride | A350619 Hydrochloride is an activator of guanylyl cyclase (sGC). It activates basal sGC and synergistically activates sGC in the presence of NO. Acting as an sGC stimulator, it may be more effective than PDE5 inhibitors in the treatment of ED. Group: Biochemicals. Grades: Highly Purified. CAS No. 1217201-17-6. Pack Sizes: 5mg, 10mg. Molecular Formula: C21H26Cl2N2OS, Molecular Weight: 425.41. US Biological Life Sciences. | Worldwide |
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