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| Product | Description | |
|---|---|---|
| Methylglyoxal bis-(guanylhydrazone)*dihy drochloride | Methylglyoxal bis-(guanylhydrazone)*dihy drochloride. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Methylglyoxalbis(guanylhydrazone)hydratedihydrochloride;2,2-(1-Methyl-1,2-ethanediylidene) bis(hydrazinecarboximidamide) dihydrochloride hydrate. CAS No. 332360-02-8. Molecular formula: CH3C[=NNHC(=NH)NH2]CH[=NNHC(=NH)NH2]2HClxH2O. Mole weight: 0. Purity: 0.96. Product ID: ACM332360028. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 2,6-Adamantanedione | 2,6-Adamantanedione, can be used for the synthesis of series of adamantane-substituted guanylhydrazones, acting as novel inhibitors of butyrylcholinesterase. It can also be used for the synthesis of the first long-lived bis-silene. Group: Biochemicals. Grades: Highly Purified. CAS No. 39751-07-0. Pack Sizes: 100mg, 1 g. Molecular Formula: C10H12O2. US Biological Life Sciences. |  Worldwide |
| 3,3'-(1-Methylethane-1,2-diylidene)dicarbazamidine dihydrochloride | 3,3'-(1-Methylethane-1,2-diylidene)dicarbazamidine dihydrochloride. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Guanylhydrazone, Methyl-Gag, Methyl-G, Methyl GAG, MGBG, MGGH, MITOGUAZONE, NSC32946, NSC69432, CID5351153, Methylglyoxal bis(guanylhydrazone) dihydrochloride, Methylglyoxal bis(guanylhydrazone)dihydrochloride, Methyl glyoxal bis(amidinohydrazone) dihydrochloride, Guanidine, 1,1-methylethanediylidenedinitrilo)di-, dihydrochloride, 7059-23-6, Guanidine, 1,1-[(methylethanediylidene)dinitrilo]di-, dihydrochloride, Guanidine, 1,1-[(methylethanediylidene)dinitrilo]di-, dihydrochloride, monohydrate, Hydrazinecarboximidamide, 2,2-(1-methyl-1,2-ethanediylidene)bis-, dihydrochloride. Product Category: Heterocyclic Organic Compound. CAS No. 7059-23-6. Molecular formula: C5H12N8.2HCl. Mole weight: 219.655380 [g/mol]. Purity: 0.96. IUPACName: 2-[(E)-[(1E)-1-(diaminomethylidenehydrazinylidene)propan-2-ylidene]amino]guanidine chloride. Product ID: ACM7059236. Alfa Chemistry ISO 9001:2015 Certified. | |
| 5-Hydroxy-2-adamantanone | 5-Hydroxy-2-adamantanone is used in the hydrosilylation of hydroxyketones. Also used in the preparation of adamantane substituted guanylhydrazones as inhibitors of butyrylcholinesterase, natural enzymes affecting succinic acid regulation. Group: Biochemicals. Alternative Names: 1-Hydroxy-4-adamantanone; 1-Hydroxy-4-ketoadamantane; 4-Oxo-1-adamantanol; 5-Hydroxy-2-adamantanone; 5-Hydroxyadamantanone; Idramantone; Kemantan; Kemantane; 5-Hydroxy-tricyclo[3.3.1.13, 7]decanone; 5-Hydroxytricyclo[3. 3. 1. 13, 7]decan-2-one. Grades: Highly Purified. CAS No. 20098-14-0. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| 5-Hydroxy-2-adamantanone | Idramantone, an immune agonist, can be used to prepare adamantane substituted guanylhydrazones. Synonyms: 5-hydroxyadamantan-2-one. CAS No. 20098-14-0. Molecular formula: C10H14O2. Mole weight: 166.22. |  |
| Mitoguazone | Mitoguazone is a guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme involved in the synthesis of polyamines, resulting in decreased proliferation of tumor cells, antimitochondrial effects, and p53-independent apoptosis. Polyamines, specifically spermine and spermidine, are essential for thymidine kinase production, DNA synthesis, and cell proliferation. Synonyms: MeGAG; methyl-G; methyl-GAG; MGBG; MGGH; DRG-0223; DRG 0223; DRG0223; NSC32946; NSC 32946; NSC-32946. Grades: 99.38%. CAS No. 459-86-9. Molecular formula: C5H12N8. Mole weight: 184.21. | |
| Mitoguazone | Mitoguazone (Methylglyoxal-bis(guanylhydrazone)) is a synthetic polycarbonyl derivative with potent antineoplastic activity. Mitoguazone is a brain-penetrant and competitive S-adenosyl-methionine decarboxylase (SAMDC) inhibitor that disrupts polyamine biosynthesis. Mitoguazone induces cell apoptosis. Mitoguazone inhibits HIV DNA integration into the cellular DNA in both monocytes and macrophages. Mitoguazone has the potential for acute leukemia, Hodgkin's and non-Hodgkin's lymphoma treatment [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Methylglyoxal-bis(guanylhydrazone); MGBG; Methyl-GAG. CAS No. 459-86-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-106634. |  |
| Mitoguazone dihydrochloride monohydrate | Mitoguazone dihydrochloride monohydrate (CAS# 332360-02-8 ) is a useful research chemical. Synonyms: Methylglyoxal bis(guanylhydrazone) hydrate dihydrochloride; 2,2'-(1-Methyl-1,2-ethanediylidene) bis(hydrazinecarboximidamide) dihydrochloride hydrate; Methylglyoxal bis(guanylhydrazone) dihydrochloride hydrate; Methyl GAG dihydrochloride monohydrate; Methylglyoxal bis(guanylhydrazone) dihydrochloride monohydrate; 2,2'-(Propane-1,2-diylidene)di(hydrazine-1-carboximidamide)-hydrogen chloride-water. CAS No. 332360-02-8. Molecular formula: C5H16Cl2N8O. Mole weight: 275.14. | |
| NSC 109555 | NSC 109555. Group: Biochemicals. Alternative Names: 4,4'-Diacetyldiphenylurea bis(guanylhydrazone) Bismethanesulfonate; 2, 2'- [Carbonyl bis (imino-4, 1-phenyl ene ethyl idyne ) ] bis-hydrazinecarboximidam ide Dimethanesulfonate. Grades: Highly Purified. CAS No. 15427-93-7. Pack Sizes: 10mg. Molecular Formula: C21H32N10O7S2, Molecular Weight: 600.669999999999. US Biological Life Sciences. | Worldwide |
| NSC 109555 ditosylate | NSC-109555 Ditosylate is an ATP-competitive Chk2 inhibitor with IC50 value of 0.2 μM. It acts by inhibiting histone H1 phosphorylation and attenuating mitochondrial ATP synthesis. It is an antileukemic agent. Synonyms: NSC-109555 Ditosylate; NSC 109555 Ditosylate; NSC109555 Ditosylate; 4,4'-diacetyldiphenylurea bis(guanylhydrazone) ditosylate. Grades: ≥98% by HPLC. CAS No. 66748-43-4. Molecular formula: C19H24N10O.2C7H8O3S. Mole weight: 752.86. | |
| Sardomozide | Sardomozide, also known as SAM486A or CGP48664, is a second-generation polyamine synthesis inhibitor, which inhibits the activity of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC). SAM486 is more potent and specific than the first-generation SAMDC inhibitor methylglyoxal (bis) guanylhydrazone (MGBG). Preclinical testing confirmed promising antiproliferative activity. The in vitro tests showed that p53 wild-type NB cells were highly sensitive to SAM486A treatment. Most notably, SAM486A treatment resulted in the rapid accumulation of proapoptotic proteins p53 and Mdm2. The in vivo phosphorylation of p53 at residues Ser(46)/Ser(392) and Mdm2 at residue Ser(166) was observed. SAM486A may be effective alternative agents for the treatment of NBs with or without MYCN amplification. Uses: Antineoplastic agents. Synonyms: CGP 48664; CGP-48664; CGP48664; SAM 486A; SAM-486A; SAM486A. Grades: >98%. CAS No. 149400-88-4. Molecular formula: C11H14N6. Mole weight: 230.27. | |
| Semapimod hydrochloride | Semapimod (INN), formerly known as CNI-1493, is a cytokine inhibitor. Semapimod is an investigational new drug which has anti-inflammatory, anti-cytokine, immunomodulatory, antiviral and antimalarial properties. Structurally, semapimod is synthetic guanylhydrazone mitogen-activated protein kinase blocker, as a potential treatment for Crohn's disease and other inflammatory conditions. Clinical trials of Semapimod started in 2001. Synonyms: CNI-1493; CNI 1493; CNI1493; AXD455; AXD 455; AXD-455; AIDS121302; AIDS-121302; AIDS 121302. Grades: >98%. CAS No. 164301-51-3. Molecular formula: C34H56Cl4N18O2. Mole weight: 890.746. | |
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