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2`,3`-Dideoxy-5`-guanylic Acid 2`,3`-Dideoxy-5`-guanylic Acid is a component used in pyrophosphorolysis activated polymerization applied to allele-specific amplification and nucleic acid sequence detection. Group: Biochemicals. Grades: Highly Purified. CAS No. 85956-71-4. Pack Sizes: 25mg, 100mg. Molecular Formula: C10H14N5O6P, Molecular Weight: 331.22. US Biological Life Sciences. USBiological 9
Worldwide
2'-Deoxy-5'-guanylic Acid Disodium Salt Hydrate 2'-Deoxy-5'-guanylic Acid Disodium Salt Hydrate is a substrate of guanylate kinase. Group: Biochemicals. Grades: Highly Purified. CAS No. 146877-98-7. Pack Sizes: 500mg, 1g. Molecular Formula: C10H14N5Na2O7P. (H2O)x, Molecular Weight: 393.201801999999. US Biological Life Sciences. USBiological 10
Worldwide
3'-O-Methyl-5'-guanylic acid 3’-O-Methyl-5’-guanylic acid is a pivotal molecule extensively employed in the realm of compound is assuming an eminent position in the research and development of sundry pharmaceutical agents and investigations concerning RNA and DNA architectures. Synonyms: 3'-Ome-GMP; [(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-4-hydroxy-3-methoxyoxolan-2-yl]methyl dihydrogen phosphate. CAS No. 400806-41-9. Molecular formula: C11H16N5O8P. Mole weight: 377.25. BOC Sciences 3
5'-Guanylic acid 5'-Guanylic acid. Group: Biochemicals. CAS No. 85-32-5. Pack Sizes: 5mg. US Biological Life Sciences. USBiological 9
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5'-Guanylic acid,8-bromo-,monosodium salt(9ci) Heterocyclic Organic Compound. Alternative Names: B2131_SIGMA, 8-Bromoguanosine 5-monophosphate sodium salt, 8-Bromoguanosine 5 inverted exclamation marka-monophosphate sodium salt, 102213-02-5. CAS No. 102213-02-5. Molecular formula: C10H13BrN5O8P.Na. Mole weight: 464.1. Purity: 0.96. IUPACName: [5-(2-amino-8-bromo-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate;sodium. Canonical SMILES: C (C1C (C (C (O1)N2C3=C (C (=O)N=C (N3)N)N=C2Br)O)O)OP (=O) (O)[O-]. [Na+]. Catalog: ACM102213025. Alfa Chemistry. 3
2'-Deoxy-2'-fluoroguanosine-5'-monophosphate 2'-Deoxy-2'-fluoroguanosine-5'-monophosphate is a vital compound used in the biomedical industry. It exhibits therapeutic potential in the treatment of certain viral infections and cancer. This product could be employed as an antiviral agent, targeting viral replication pathways, or as an anticancer agent for inhibiting tumor growth. Synonyms: 2'-Deoxy-2'-fluoro-5'-guanylic acid. CAS No. 170784-58-4. Molecular formula: C10H13FN5O7P. Mole weight: 365.21. BOC Sciences 3
2'-Deoxy-6-thioguanosine-5'-monophosphate 2'-Deoxy-6-thioguanosine-5'-monophosphate is an innovative pharmaceutical entity, exquisitely designed for unveiling remarkable antiviral potency, assiduously directing its action towards impeding the pernicious propagation of RNA viruses. Deploying its inhibitory prowess upon viral enzyme activity, it efficaciously curtails the abhorrent virus's proclivity to proliferate, ensuing in a substantial amelioration of both the intensity and duration of the affliction. Synonyms: 2'-Deoxy-6-thio-5'-guanylic acid. CAS No. 15303-00-1. Molecular formula: C10H14N5O6PS. Mole weight: 363.29. BOC Sciences 3
2'-Deoxyguanosine 3'-monophosphate sodium salt 2'-Deoxyguanosine 3'-monophosphate sodium salt. Alternative Names: 2-Deoxyguanosine-3-Monophosphate; 2-DEOXYGUANOSINE 3-MONOPHOSPHATE SODIUM; 2-Deoxy-3-guanylic acid disodium salt. CAS No. 102814-03-9. Molecular formula: C10H12N5O7P·2Na. Mole weight: 391.19. Purity: 0.96. IUPACName: disodium;[(2R,3S,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-2-(hydroxymethyl)oxolan-3-yl]phosphate. Canonical SMILES: C1C (C (OC1N2C=NC3=C2NC (=NC3=O)N)CO)OP (=O) ([O-])[O-]. [Na+]. [Na+]. Catalog: ACM102814039. Alfa Chemistry. 3
2'-Deoxyguanosine-5'-monophosphate 2'-Deoxyguanosine-5'-monophosphate, a nucleotide molecule and a key player in DNA synthesis, holds immense potential in the development of antiviral drugs as well as in treating various cancers. This biochemical marker is additionally crucial in detecting and measuring DNA damage, a necessary step in studying the complex mechanisms of DNA replication and repair. Synonyms: 2'-Deoxyguanylic acid; dGMP; Deoxyguanylic acid; Deoxy-GMP; 2'-Deoxyguanosine 5'-phosphate; Deoxyguanosine 5'-monophosphate; 2'-Deoxy-GMP; 2'-Deoxy-5'-guanylic acid; Guanosine, 2'-deoxy-, 5'-(dihydrogen phosphate); 2'-Desoxyguanosine 5'-(dihydrogen phosphate); 9-(2-Deoxy-5-O-phosphono-β-D-erythro-pentofuranosyl)-2-imino-3,9-dihydro-2H-purin-6-ol. Grades: ≥98% by HPLC. CAS No. 902-04-5. Molecular formula: C10H14N5O7P. Mole weight: 347.22. BOC Sciences 2
2'-O-Methylguanosine 5'-monophosphate triethylammonium salt 2'-O-Methylguanosine 5'-monophosphate triethylammonium salt is a critical compound extensively used in the biomedical industry. It plays a crucial role in the treatment and research of various diseases, including viral infections, cancer, and neurological disorders. This product contributes to the development of targeted therapies and is an essential component in nucleic acid-based drug formulations. Its high purity and quality make it a valuable tool for biomedical research and drug discovery. Synonyms: 2'-O-Methyl-5'-guanylic acid; 2'-O-Mgmp; 2'-O-Methylguanosine 5'-monophosphate; [(2R,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxy-4-methoxyoxolan-2-yl]methyl dihydrogen phosphate. Grades: ≥ 95%. CAS No. 24121-01-5. Molecular formula: C11H16N5O8P. Mole weight: 377.25. BOC Sciences 3
5'-Phosphoryl-(3'-amino-3'-deoxyguanylyl)-(3'-5')-3'-amino-3'-deoxycytidine 5'-Phosphoryl-(3'-amino-3'-deoxyguanylyl)-(3'-5')-3'-amino-3'-deoxycytidine is a highly significant compound extensively employed in the biomedical sector, holding immense therapeutic potential for research of viral infections. Moreover, this remarkable compound exhibits auspicious outcomes in impeding the proliferation of neoplastic cells. Synonyms: [(2R,3S,4R,5R)-4-Amino-2-[[(2R,3S,4R,5R)-4-amino-5-(4-amino-2-oxo-pyri midin-1-yl)-3-phosphonooxy-oxolan-2-yl]methoxymethyl]-5-(2-amino-6-oxo-3H-purin-9-yl)oxolan-3-yl]oxyphosphonic acid; 5'-Guanylic acid,3'-amino-3'-deoxycytidylyl-(5'-3')-3'-amino-3'-deoxy; Padgdc. CAS No. 109679-54-1. Molecular formula: C19H28N10O13P2. Mole weight: 666.43. BOC Sciences 3
(7R,8S,9S)-Trihydroxy-10S(N2-deoxyguanosyl-3'-phosphate)-7,8,9,10-tetrahydrobenzo[a]pyrene Triethylamine A metabolite of the environmental carcinogen benzo(a)pyrene, which is a benzopyrene-DNA adduct formed during subchronic dietary exposure to carcinogen benzo(a)pyrene (BaP). Synonyms: [7R-(7α, 8β, 9α, 10α)]-2'-Deoxy-N-(7, 8, 9, 10-tetrahydro-7, 8, 9-trihydroxybenzo[a]pyren-10-yl)-3'-guanylic Acid. Molecular formula: C36H43N6O10P. Mole weight: 750.73. BOC Sciences 3
8-Hydroxydeoxyguanosine 5'-monophosphate sodium salt 8-Hydroxydeoxyguanosine 5'-monophosphate sodium salt is an indispensable resource, playing a pivotal role in probing intricate oxidative DNA impairment and mending mechanisms. It finds extensive utility in uncovering the ramifications inflicted by reactive oxygen species on afflictions like cancer and neurodegenerative ailments. Synonyms: 5'-Guanylic acid, 2'-deoxy-7,8-dihydro-8-oxo-, sodium salt (1:2). CAS No. 1679384-24-7. Molecular formula: C10H14N5O8P.2Na. Mole weight: 409.2. BOC Sciences 9
c-Di-GMP c-diGMP is a bacterial second messenger and a STING ligand. Synonyms: 3'-Guanylic acid, guanylyl-(3'?5')-, cyclic nucleotide; 5GP-5GP; Cyclic di-3',5'-guanylate; Cyclic diguanylate; Cyclic diguanylate monophosphate; Cyclic-di-GMP. Grades: ≥95%. CAS No. 61093-23-0. Molecular formula: C20H24N10O14P2. Mole weight: 690.41. BOC Sciences 8
Disodium[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Heterocyclic Organic Compound. Alternative Names: Disodium guanylate, Sodium 5-guanylate, 5-GMP-Na2, AC1NB07Z, MolPort-001-560-962, 111036-20-5, AKOS000493527, AKOS003237988, AKOS003307678, 5-Guanylic acid disodium salt hexahydrate, I07-0020, dipotassium [5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate, disodium [5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate. CAS No. 111036-20-5. Molecular formula: C10H12N5Na2O8P. Mole weight: 407.184 g/mol. Purity: 0.96. IUPACName: disodium;[5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate. Catalog: ACM111036205. Alfa Chemistry.
GMP Guanosine 5'-monophosphate has been found to be useful in studies of modulation of glutamatergic neurotransmission. Synonyms: Guanosine-5'-monophosphate; 5'-Guanylic Acid. Grades: ≥ 95 % by HPLC. Molecular formula: C10H14N5O8P. Mole weight: 363.22. BOC Sciences 2
Guanosine-2'(3')-monophosphate disodium salt Guanosine-2'(3')-monophosphate disodium salt, a remarkable biomedicine product, emerges as a potent weapon in combating a myriad of multifarious diseases. Its unrivaled prowess as a precursor to cyclic guanosine monophosphate, an integral second messenger orchestrating intricate cellular signaling pathways, renders it indispensable. Synonyms: Guanylic acid disodium salt; Guanosine 2'-3'-monophosphate disodium salt mixed Isomers; 2'-Guanylic acid, disodium salt; (2R,3R,4R,5R)-2-(2-amino-6-hydroxypurin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxola n-3-yl dihydrogen phosphate, sodium salt, sodium salt. Grades: 98%. CAS No. 70347-42-1. Molecular formula: C10H12N5O8PNa2. Mole weight: 407.18. BOC Sciences 3
Guanosine-2'(&3')-monophosphate disodium salt (mixed isomers) Guanosine-2'(&3')-monophosphate disodium salt (mixed isomers). Group: Biochemicals. Alternative Names: Guanylic acid disodium salt; Guanosine 2'-3'-monophosphate disodium salt mixed Isomers. Grades: Highly Purified. Pack Sizes: 250mg. US Biological Life Sciences. USBiological 8
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Guanosine 5'-monophosphate Guanosine 5'-monophosphate is a purine ribonucleoside 5'-monophosphate having guanine as the nucleobase. It has a role as a metabolite, a biomarker, an Escherichia coli metabolite and a mouse metabolite. It is a guanosine 5'-phosphate and a purine ribonucleoside 5'-monophosphate. It is a conjugate acid of a guanosine 5'-monophosphate(2-). Guanosine 5'-monophosphate. A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature. Synonyms: 5-Guanylic Acid; 5'-GMP; GMP; Guanidine Monophosphate; Guanosine 5'-Phosphate; Guanosine 5'-Phosphoric Acid; Guanosine Monophosphate; Guanylic Acid. Grades: ≥95%. CAS No. 85-32-5. Molecular formula: C10H14N5O8P. Mole weight: 363.22. BOC Sciences 2
Guanosine 5'-monophosphate calcium salt Calcium guanylate is a compound with formula Ca(C10H12O4N5PO4). It is the calcium salt of guanylic acid. As a food additive, it is used as a flavor enhancer and has the E number E629. Synonyms: Calcium 5'-guanylate; Guanylic acid calcium salt; calcium,[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate; 5'-Guanylic acid calcium salt; Calcium guanylate; Calcium 5'-O-phosphonatoguanosine. Grades: ≥ 95%. CAS No. 38966-30-2. Molecular formula: C10H12CaN5O8P. Mole weight: 401.28. BOC Sciences
Guanosine 5'-monophosphate disodium salt Disodium guanylate, also known as sodium 5'-guanylate and disodium 5'-guanylate, is a natural sodium salt of the flavor enhancing nucleotide guanosine monophosphate (GMP). Disodium guanylate is a food additive with the E number E627. It is commonly used in conjunction with glutamic acid (monosodium glutamate, MSG). As it is a fairly expensive additive, it is not used independently of glutamic acid; if disodium guanylate is present in a list of ingredients but MSG does not appear to be, it is likely that glutamic acid is provided as part of another ingredient such as a processed soy protein complex. It is often added to foods in conjunction with disodium inosinate; the combination is known as disodium 5'-ribonucleotides. Disodium guanylate is produced from dried seaweed and is often added to instant noodles, potato chips and other snacks, savory rice, tinned vegetables, cured meats, and packaged soup. Synonyms: Disodium guanylate; Disodium GMP; Disodium 5'-gmp; GMP disodium salt; 5'-Gmp disodium salt; Disodium guanosine-5'-monophosphate; 5'-Guanylic acid disodium salt; Sodium 5'-guanylate; Guanosine 5'-phosphate disodium salt. Grades: 98%. CAS No. 5550-12-9. Molecular formula: C10H12N5O8P·2Na. Mole weight: 407.18. BOC Sciences
Guanosine 5'-Monophosphate Ester 6-Deoxytalose Sodium Salt Guanosine 5'-Monophosphate Ester 6-Deoxytalose Sodium Salt is used in the synthetic preparation of nucleoside monophosphate sugars such as GMP-Fucose. Synonyms: 5'-Guanylic Acid Mono(6-deoxy-α-L-galactopyranosyl) Ester Sodium Salt. Molecular formula: C16H23N5NaO12P. Mole weight: 531.34. BOC Sciences 3
Guanosine 5'-O-(2-Thiodiphosphate) Trilithium Salt Guanosine 5'-O-(2-Thiodiphosphate) Trilithium Salt is a GDP analog which could inhibits G-protein activation. Synonyms: 5'-Guanylic acid, monoanhydride with phosphorothioic acid, trilithium salt; EINECS 308-328-9; Guanosine 5'-O-(2-thiodiphosphate) trilithium salt; trilithium; [(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dioxidophosphinothioyl phosphate; Guanosine 5'-[beta-thio]diphosphate trilithium salt; GDP-beta-S-Li3; GDPbetaS trilithium salt; Guanosine 5'-O-(2-Thiodiphosphate), Trilithium Salt; MFCD00057735; Guanosine 5-O-(2-thiodiphosphate)trilithium salt; Guanosine,5'-esterwith thiodiphosphoric acid([(ho)2p(o)]2s)(9ci); Guanosine 5'-[beta-thio]diphosphate trilithium salt, >=85% (HPLC), powder. CAS No. 97952-36-8. Molecular formula: C10H12Li3N5O10P2S. Mole weight: 477.07. BOC Sciences 2
hypoxanthine phosphoribosyltransferase Guanine and 6-mercaptopurine can replace hypoxanthine. Group: Enzymes. Synonyms: IMP pyrophosphorylase; transphosphoribosidase; hypoxanthine-guanine phosphoribosyltransferase; guanine phosphoribosyltransferase; GPRT; HPRT; guanosine 5'-phosphate pyrophosphorylase; IMP-GMP pyrophosphorylase; HGPRTase; 6-hydroxypurine phosphoribosyltransferase; 6-mercaptopurine phosphoribosyltransferas. Enzyme Commission Number: EC 2.4.2.8. CAS No. 9016-12-0. HGPRT. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2691; hypoxanthine phosphoribosyltransferase; EC 2.4.2.8; 9016-12-0; IMP pyrophosphorylase; transphosphoribosidase; hypoxanthine-guanine phosphoribosyltransferase; guanine phosphoribosyltransferase; GPRT; HPRT; guanosine 5'-phosphate pyrophosphorylase; IMP-GMP pyrophosphorylase; HGPRTase; 6-hydroxypurine phosphoribosyltransferase; 6-mercaptopurine phosphoribosyltransferase; GMP pyrophosphorylase; guanine-hypoxanthine phosphoribosyltransferase; guanosine phosphoribosyltransferase; guanylate pyrophosphorylase; guanylic pyrophosphorylase; inosinate pyrophosphorylase; inosine 5'-phosphate pyrophosphorylase; inosinic acid pyrophosphorylase; inosinic pyrophosphorylase; 6-mercaptopurine phosphoribosyltransferase; purine-6-thiol phosphoribosyltransferase. Cat No: EXWM-2691. Creative Enzymes
Ribonuclease T2 from Aspergillus oryzae, Recombinant Aspergillus oryzae Ribonuclease T2 is a member of the RNase T2 family of endonucleases that are present in a wide variety of microbial, plant and animal species. In contrast to Aspergillus oryzae Ribonuclease T1, which is an exclusively guanylic-acid specific endonuclease, all RNase T2-like enzymes are essentially base non-specific. However, RNase T2 endonucleases from different species can show slight base preferences. The fungal enzymes, including Aspargillus oryzae RNaseT2, show slight base preference in the following order: A>G>C, U. RNase T2 cleaves between the 3-phosphate residue of one base and the 5-OH residue of the adjacent nucleotide forming a 2, 3-cyclic phosphate intermediate followed by the generation of oligonucleotides with 3-phosphate residues. This enzyme is also used as a non-mammalian source of RNase in various applications. Group: Enzymes. Synonyms: Ribonuclease T2; RNase T2; Ribonuclease. Enzyme Commission Number: EC 3.1.27.1. Rnase. Mole weight: 36 kDa. Activity: ≥10,000 units per mg protein. Stability: Stable at 12-18 months at 2-8°C. Storage: Store at 2-8°C. Form: Lyophilized powder. Source: Pichia pastoris. Species: Aspergillus oryzae. Ribonuclease T2; RNase T2; Ribonuclease. Cat No: NATE-1930. Creative Enzymes
1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile is used in various studies of stimulators of soluble guanylate cyclase. Group: Biochemicals. Grades: Highly Purified. CAS No. 256376-65-5. Pack Sizes: 100mg, 250mg. Molecular Formula: C14H9FN4. US Biological Life Sciences. USBiological 9
Worldwide
1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide Hydrochloride 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide Hydrochloride is a key intermediate in the synthesis of Riociguat, a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension. Group: Biochemicals. Grades: Highly Purified. CAS No. 256499-19-1. Pack Sizes: 250mg, 500mg. Molecular Formula: C14H13ClFN5. US Biological Life Sciences. USBiological 9
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1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylic Acid Ethyl Ester 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylic Acid Ethyl Ester is used in various studies of stimulators of soluble guanylate cyclase. Group: Biochemicals. Grades: Highly Purified. CAS No. 256376-59-7. Pack Sizes: 5mg, 25mg. Molecular Formula: C16H14FN3O2. US Biological Life Sciences. USBiological 9
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1-?[ (3-Fluorophenyl) ?methyl]?-1H-?pyrazolo[3, ?4-?b]?pyridine-?3-?carboximidamide 1-?[ (3-Fluorophenyl) ?methyl]?-1H-?pyrazolo[3, ?4-?b]?pyridine-?3-?carboximidamide is a useful reactant in preparation of pyrrolopyrimidinone derivatives as soluble guanylate cyclase activators. Group: Biochemicals. Grades: Highly Purified. CAS No. 2101651-50-5. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C14H12FN5, Molecular Weight: 269.279999999999. US Biological Life Sciences. USBiological 9
Worldwide
1-b-D-Ribofuranosyl-3-guanylurea picrate 1-b-D-Ribofuranosyl-3-guanylurea picrate is a specialized compound used in biomedicine for antiviral research, specifically targeting Hepatitis C. Studies have shown its potential to inhibit viral RNA replication. Synonyms: 1-(Diaminomethylene)-3-(beta-D-ribofuranosyl)urea picrate; 1-Amidino-3-b-D-ribofuranosylurea monopicrate; Azacitidine Related Compound C. CAS No. 4336-46-3. Molecular formula: C13H17N7O12. Mole weight: 463.31. BOC Sciences
1-D-Ribofuranosyl-3-guanylurea (α/β-Mixture) A labile hydrolysis product of the antitumor nuceloside 5-Azacytidine. Synonyms: N-(aminoiminomethyl)-N'-D-ribofuranosylurea; 1-Amidino-3-D-ribofuranosylurea. Grades: 95%. Molecular formula: C7H14N4O5. Mole weight: 234.21. BOC Sciences 12
1-Ethyl-3-guanidinothiourea Hydrochloride 1-Ethyl-3-guanidinothiourea Hydrochloride. Group: Biochemicals. Alternative Names: 1-Amidino-3-ethylthiourea Hydrochloride; 1-Carbamimidoyl-3-ethylthiourea Hydrochloride; 1-Ethyl-3-guanylthiourea Hydrochloride. Grades: Highly Purified. CAS No. 381670-29-7. Pack Sizes: 2g, 5g, 10g, 25g, 50g. US Biological Life Sciences. USBiological 7
Worldwide
1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one inhibits neurite outgrowth and causes neurite retraction in PC12 cells independently of soluble guanylyl cyclase. Group: Biochemicals. Alternative Names: ODQ. Grades: Highly Purified. CAS No. 41443-28-1. Pack Sizes: 50mg. US Biological Life Sciences. USBiological 2
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1-Methyl Biguanide Hemisulfate Monohydrate N-Demethylated analog of Metformin with stimulatory effects on the intracellular portion of human insulin receptor (IP βIRK). Group: Biochemicals. Alternative Names: N- methyl imidodicarbonimidic Diamide Hemisulfate Monohydrate; N-Methyl-N'-guanylguanidine Hemisulfate Monohydrate. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. USBiological 2
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1-Phenyl-3-guanylthiourea 1-Phenyl-3-guanylthiourea. Group: Biochemicals. Alternative Names: 1-Amidino-3-phenylthiourea; 1-Carbamimidoyl-3-phenylthiourea. Grades: Highly Purified. CAS No. 15989-47-6. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. US Biological Life Sciences. USBiological 8
Worldwide
2- (1- (2-Fluorobenzyl) -1H-pyrazolo[3, 4-b]pyridin-3-yl) -5- (phenyldiazenyl) pyrimidine-4, 6-diamine 2- (1- (2-Fluorobenzyl) -1H-pyrazolo[3, 4-b]pyridin-3-yl) -5- (phenyldiazenyl) pyrimidine-4, 6-diamine is a metabolite of stimulators of soluble guanylate cyclase for the treatment of pulmonary hypertension. Group: Biochemicals. Grades: Highly Purified. CAS No. 428854-23-3. Pack Sizes: 1g, 2.5g. Molecular Formula: C23H18FN9, Molecular Weight: 439.45. US Biological Life Sciences. USBiological 9
Worldwide
2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine is a metabolite of stimulators of soluble guanylate cyclase for the treatment of pulmonary hypertension. Group: Biochemicals. Grades: Highly Purified. CAS No. 428854-24-4. Pack Sizes: 50mg, 100mg. Molecular Formula: C17H15FN8. US Biological Life Sciences. USBiological 9
Worldwide
2,6-Adamantanedione 2,6-Adamantanedione, can be used for the synthesis of series of adamantane-substituted guanylhydrazones, acting as novel inhibitors of butyrylcholinesterase. It can also be used for the synthesis of the first long-lived bis-silene. Group: Biochemicals. Grades: Highly Purified. CAS No. 39751-07-0. Pack Sizes: 100mg, 1 g. Molecular Formula: C10H12O2. US Biological Life Sciences. USBiological 10
Worldwide
2-Amino-4,6-dihydroxypyrimidine-13C2 2-Amino-4,6-dihydroxypyrimidine-13C2 is an intermediate in the production of antimicrobial guanylsulfonamides. Group: Biochemicals. Alternative Names: 2-Amino-6-hydroxy-4(3H)-pyrimidinone-13C2; 2-Amino-4,6-pyrimidinediol-13C2; 2-Amino-4,6-dioxypyrimidine-13C2; 4,6-Dihydroxy-2-aminopyrimidine-13C2; NSC 15920-13C2; NSC 18692-13C2. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. USBiological 3
Worldwide
2-Cl-ATP 2-Cl-ATP is an agonist of P2Y purinoceptor that inhibits soluble guanylate cyclase. Synonyms: 2- Chloroadenosine- 5'- triphosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 49564-60-5. Molecular formula: C10H15ClN5O13P3 (free acid). Mole weight: 541.6 (free acid). BOC Sciences 3
2-Cyclopropylcarbonyl-3-dimethylaminoacrylic Acid Methyl Ester 2-Cyclopropylcarbonyl-3-dimethylaminoacrylic Acid Methyl Ester is an intermediate in the preparation of soluble guanylyl cyclase activators. Group: Biochemicals. Alternative Names: α -[ (Dimethylamino) methylene]- β-oxo-cyclopropanepropanoic Acid Methyl Ester;Methyl 2- (Cyclopropylcarbonyl) -3- (dimethylamino) acrylate; Methyl 2-(Cyclopropylcarbonyl)-3-(dimethylamino)prop-2-enoate. Grades: Highly Purified. CAS No. 340774-26-7. Pack Sizes: 500mg. US Biological Life Sciences. USBiological 3
Worldwide
2'-deoxyguanylyl-(3'-5')-2'-deoxyguanosine 2'-Deoxyguanylyl-(3'-5')-2'-deoxyguanosine, an essential nucleotide analogue, possesses remarkable inhibitory traits that deter DNA synthesis. Within biomedicine, this distinctive product successfully combats specific cancer types such as leukemia and lymphoma via its disruptive function against cancer cells' proliferation, ultimately leading to their demise. With its powerful mechanism of action, it represents a vital tool within cancer research and therapy. Synonyms: dGpdG DNA Dinucleotide (5'-3'); 2'-Deoxy-3'-O-(2'-deoxy-5'-guanylyl)guanosin. Grades: ≥95% by AX-HPLC. Molecular formula: C20H25N10O10P. Mole weight: 596.40. BOC Sciences 3
2-Imino-4-thiobiuret 2-Imino-4-thiobiuret is used in the design and synthesis of guanylthiourea derivatives which are potential inhibitors of plasmodium falciparum dihydrofolate reductase enzyme. 2-Imino-4-thiobiuret is also used as a reagent in recyclization reactions of N-arylmaleimides with polynucleophilic compounds. Group: Biochemicals. Grades: Highly Purified. CAS No. 2114-2-5. Pack Sizes: 5g, 10g. Molecular Formula: C2H6N4S, Molecular Weight: 118.16. US Biological Life Sciences. USBiological 10
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2-MeS-ATP 2-MeS-ATP is an agonist of P2Y purinoceptors that inhibits soluble guanylate cyclase. Uses: Purinergic agonists. Synonyms: 2- Methylthioadenosine- 5'- O- triphosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 43170-89-4. Molecular formula: C11H18N5O13P3S (free acid). Mole weight: 553.3 (free acid). BOC Sciences 2
2-phospho-L-lactate guanylyltransferase This enzyme is involved in the biosynthesis of coenzyme F420, a redox-active cofactor found in all methanogenic archaea, as well as some eubacteria. Group: Enzymes. Synonyms: CofC; MJ0887. Enzyme Commission Number: EC 2.7.7.68. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3279; 2-phospho-L-lactate guanylyltransferase; EC 2.7.7.68; CofC; MJ0887. Cat No: EXWM-3279. Creative Enzymes
3-Cyano-2-oxo-propionic Acid Ethyl Ester Sodium Salt 3-Cyano-2-oxo-propionic Acid Ethyl Ester Sodium Salt is used in the preparation of stimulators of soluble guanylate cyclase. Group: Biochemicals. Grades: Highly Purified. CAS No. 53544-13-1. Pack Sizes: 500mg, 1g. Molecular Formula: C6H6NNaO3, Molecular Weight: 163.11. US Biological Life Sciences. USBiological 1
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4-Phenyl-3-furoxancarbonitrile (Furoxan, RVC-589) Able to activate the soluble guanylate cyclase by releasing Nitric Oxide under the action of thiol cofactors. Also inhibits platelet aggregation. Group: Biochemicals. Alternative Names: Furoxan, RVC-589. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. USBiological 1
Worldwide
5-Hydroxy-2-adamantanone 5-Hydroxy-2-adamantanone is used in the hydrosilylation of hydroxyketones. Also used in the preparation of adamantane substituted guanylhydrazones as inhibitors of butyrylcholinesterase, natural enzymes affecting succinic acid regulation. Group: Biochemicals. Alternative Names: 1-Hydroxy-4-adamantanone; 1-Hydroxy-4-ketoadamantane; 4-Oxo-1-adamantanol; 5-Hydroxy-2-adamantanone; 5-Hydroxyadamantanone; Idramantone; Kemantan; Kemantane; 5-Hydroxy-tricyclo[3.3.1.13, 7]decanone; 5-Hydroxytricyclo[3. 3. 1. 13, 7]decan-2-one. Grades: Highly Purified. CAS No. 20098-14-0. Pack Sizes: 2.5g. US Biological Life Sciences. USBiological 3
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5-Hydroxy-2-adamantanone Idramantone, an immune agonist, can be used to prepare adamantane substituted guanylhydrazones. Synonyms: 5-hydroxyadamantan-2-one. CAS No. 20098-14-0. Molecular formula: C10H14O2. Mole weight: 166.22. BOC Sciences 9
5'-O-(2'-Deoxy-3'-guanylyl)thymidine 5'-O-(2'-Deoxy-3'-guanylyl)thymidine is a highly valuable nucleoside compound, extensively utilized in biomedical research to scrutinize the influence of modified nucleotides on the intricate DNA repair mechanisms. Furthermore, it has shown immense potential in analyzing cytotoxicity of DNA lesions caused by the exposure to hazardous radiation or chemotherapy drugs, providing a groundbreaking platform for future drug discovery and development applications. Synonyms: dGpdT DNA Dinucleotide (5'-3'). Grades: ≥95% by AX-HPLC. Molecular formula: C20H26N7O11P. Mole weight: 571.40. BOC Sciences 3
5'-O-(3'-Guanylyl)uridine 5'-O-(3'-Guanylyl)uridine, a biomolecule ubiquitous in the biomedical industry, facilitates RNA processing and translation. Notwithstanding, this biomolecule's salience is not restricted to solely association with these fundamental processes. Remarkably, it also serves as a substrate for various enzymes, mitigating the severity of viral infections, and demonstrating its potential therapeutic applications. Synonyms: guanylyl(3'-5')uridine; GpU RNA Dinucleotide (5'-3'). Grades: ≥95% by AX-HPLC. Molecular formula: C19H24N7O13P. Mole weight: 589.40. BOC Sciences 3
6-Anilino-5,8-quinolinedione (LY 83583) Inhibits nitric-oxide-induced activation of soluble guanylate cyclase (IC50=2µM) in a dose-dependent and reversible manner. It blocks acetylcholine induced vasorelaxation. Also an inhibitor of antigen-induced leukotriene release. Group: Biochemicals. Alternative Names: LY 83583. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. USBiological 1
Worldwide
8-[(6-Amino)hexyl]-amino-cGMP - ATTO-390 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-390, a luminescent marker, offers researchers a viable tool to evaluate cyclic nucleotide signaling pathways. It furnishes a mechanism to assay guanylyl cyclase action, as well as drug responsiveness. Moreover, its application has the potential for wider clinical utilization including drug delivery and cancer diagnosis. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 390, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C36H49N8O10P (free acid). Mole weight: 784.80 (free acid). BOC Sciences 2
8-[(6-Amino)hexyl]-amino-cGMP - ATTO-612Q 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-612Q, a fluorescent probe, designed to assist biomedical research in investigating guanylyl cyclase enzyme activity and cGMP-related signaling pathways, as well as studying the pathogenesis of cardiovascular diseases and cancer. The intricacies of this product are profound whilst remaining highly practical, offering a truly unique insight into its potential. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 612Q, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H24N7O7P - ATTO 612Q (free acid). Mole weight: 1131.39 (free acid). BOC Sciences 2
8-[(6-Amino)hexyl]-amino-cGMP - ATTO-647N 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-647N is a fluorescent probe used for imaging guanylyl cyclase and monitoring cGMP signaling pathways in biological systems. This product can also be utilized in the diagnosis and treatment of disorders related to the activation or inhibition of guanylyl cyclase and cGMP. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 647N, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H26N7O7P - ATTO 647N (free acid). Mole weight: 1086.39 (free acid). BOC Sciences 2
8-[(6-Amino)hexyl]-amino-cGMP - ATTO-740 8-[(6-Amino)hexyl]-amino-cGMP - ATTO-740, a fluorescent probe, is a valuable tool in biomedical research for investigating the function of guanylyl cyclases and soluble guanylate cyclases. Notably, this versatile probe can be used to study the mechanisms underlying cardiovascular diseases and neuronal disorders, thereby offering the potential for significant scientific breakthroughs and medical advancements. Its reliability and efficacy make it a highly sought-after compound for researchers across diverse fields. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with ATTO 740, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H26N7O7P - ATTO 740 (free acid). Mole weight: 908.39 (free acid). BOC Sciences 2
8-[(6-Amino)hexyl]-amino-cGMP - DY-776 DY-776, a potent and selective agonist of soluble guanylate cyclase (sGC), stands as a key target for treatment of pulmonary hypertension and other cardiovascular diseases. Operating through its heme-containing domain, the DY-776 compound effortlessly binds, exhibiting increases in cyclic guanosine monophosphate (cGMP) concentrations in smooth muscle cells facilitating the enhanced vasodilation and an improved blood flow. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-3',5'-cyclic monophosphate, labeled with DY 776. Grades: ≥ 95% by HPLC. Molecular formula: C60H72N9O15PS2 (free acid). Mole weight: 1254.37 (free acid). BOC Sciences 2
8-Nitroguanosine 2',3',5'-Triacetate 8-Nitroguanosine derivative. Used as chemical probes in protein S-guanylation by endogenous nitrated nucleosides. Synonyms: 8-Nitroguanosine 2',3',5'-Triacetate; 1096020-95-9; [(2R,3R,4R,5R)-3,4-diacetyloxy-5-(2-amino-8-nitro-6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl acetate; (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2-amino-8-nitro-6-oxo-1H-purin-9(6H)-yl)tetrahydrofuran-3,4-diyl diacetate; J-002308; [(2R,3R,4R,5R)-3,4-bis(acetyloxy)-5-(2-amino-8-nitro-6-oxo-6,9-dihydro-1H-purin-9-yl)oxolan-2-yl]methyl acetate. CAS No. 1096020-95-9. Molecular formula: C16H18N6O10. Mole weight: 454.35. BOC Sciences 3
8-Nitroguanosine 2',3',5'-Triacetate 8-Nitroguanosine (N496050) derivative. Used as chemical probes in protein S-guanylation by endogenous nitrated nucleosides. Group: Biochemicals. Grades: Highly Purified. CAS No. 1096020-95-9. Pack Sizes: 25mg. US Biological Life Sciences. USBiological 3
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9-Dihydro-8-(N7-guanyl)-9-hydroxyaflatoxin B1 9-Dihydro-8-(N7-guanyl)-9-hydroxyaflatoxin B1 is the major DNA adduct formed by the liver carcinogen aflatoxin B1. Synonyms: 2-Amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6, 9-dihydro-7-(1, 2, 3, 6a, 8, 9, 9a, 11-octahydro-9-hydroxy-4-methoxy-1, 11-dioxocyclopenta[c]furo[3', 2':4, 5]furo[2, 3-h][1]benzopyran-8-yl)-6-oxo-1H-purinium; AFB1-N7-Gua; Cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran, 1H-purinium deriv. CAS No. 64585-66-6. Molecular formula: C27H26N5O11. Mole weight: 596.52. BOC Sciences 3
A 350619 hydrochloride A 350619 hydrochloride is an activator of soluble guanylyl cyclase (sGC) that stimulates basal sGC and synergistically activates sGC in the presence of NO. It is effective for the use of ED treatment. Uses: The treatment of ed. Synonyms: A-350619 hydrochloride; A350619 hydrochloride; A 350619 hydrochloride; 3-[2-[(4-Chlorophenyl)thiophenyl]-N-[4-(dimethylamino)butyl]-2-propenamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 1217201-17-6. Molecular formula: C21H25ClN2OS.HCl. Mole weight: 425.41. BOC Sciences
A-350619 hydrochloride A-350619 hydrochloride is a soluble guanylate cyclase ( sGC ) activator. A-350619 hydrochloride can be used in the study of erectile dysfunction [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1217201-17-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-107548. MedChemExpress MCE
A350619 Hydrochloride A350619 Hydrochloride is an activator of guanylyl cyclase (sGC). It activates basal sGC and synergistically activates sGC in the presence of NO. Acting as an sGC stimulator, it may be more effective than PDE5 inhibitors in the treatment of ED. Group: Biochemicals. Grades: Highly Purified. CAS No. 1217201-17-6. Pack Sizes: 5mg, 10mg. Molecular Formula: C21H26Cl2N2OS, Molecular Weight: 425.41. US Biological Life Sciences. USBiological 3
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Ac-Linaclotide Ac-Linaclotide is an impurity of Linaclotide, which is a peptide agonist of guanylate cyclase 2C used for the treatment of abdominal pain in patients with irritable bowel syndrome (IBS) associated with constipation. Synonyms: Ac-L-cysteinyl-L-cysteinyl-L-alpha-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-aspargenyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonyl-glycyl-L-cysteinyl-L-tyrosine (1-6),(2-10),(5-13)-tris(disulfide); Ac-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH (disulfide bridges between 1-6, 2-10 and 5-13 Cysteines); N-Acetyl-linaclotide; L-Tyrosine, N-acetyl-L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (1?6),(2?10),(5?13)-tris(disulfide). CAS No. 1422389-17-0. Molecular formula: C61H81N15O22S6. Mole weight: 1568.76. BOC Sciences 2
Acylated Linaclotide Linaclotide is a 14 amino acid peptide that is a guanylate cyclase C agonist.It is suitable for the treatment of adult CC and IBS-C. Molecular formula: C61H81N15O22S6. Mole weight: 1568.76. BOC Sciences
adenosylcobinamide kinase In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyse reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl). CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, α-ribazole. The second branch of the nucleotide loop assembly pathway is the cobinamide (Cbi) activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by Cob U. The final step in adenosylcobalamin ...erase activity is required for both assimilation of exogenous cobinamide and for de novo synthesis of adenosylcobalamin. Group: Enzymes. Synonyms: CobU; adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; AdoCbi kinase/AdoCbi-phosphate guanylyltransferase. Enzyme Commission Number: EC 2.7.1.156. CAS No. 169592-51-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2985; adenosylcobinamide kinase; EC 2.7.1.156; 169592-51-2; CobU; adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; AdoCbi kinase/AdoCbi-phosphate guanylyltransferase. Cat No: EXWM-2985. Creative Enzymes
adenosylcobinamide-phosphate guanylyltransferase In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyse reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl). CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, α-ribazole. The second branch of the nuclotide loop assembly pathway is the cobinamide (Cbi) activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by the bifunctional enzyme Cob U. Th...s a two-stage reaction with formation of a CobU-GMP intermediate. Guanylylation takes place at histidine-46. Group: Enzymes. Synonyms: CobU; adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; AdoCbi kinase/AdoCbi-phosphate guanylyltransferase. Enzyme Commission Number: EC 2.7.7.62. CAS No. 169592-55-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3274; adenosylcobinamide-phosphate guanylyltransferase; EC 2.7.7.62; 169592-55-6; CobU; adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; AdoCbi kinase/AdoCbi-phosphate guanylyltransferas Creative Enzymes
ADENYLYL-(3'-5')-GUANOSINE ADENYLYL-(3'-5')-GUANOSINE, a fundamental molecule in cellular signaling pathways, is an indispensable regulator of intracellular communication. It assumes a pivotal position in the control of diverse biological phenomena encompassing DNA synthesis and repair, cell growth, as well as immune responses. In the realm of biomedicine, ADENYLYL-(3'-5')-GUANOSINE finds utility in the investigation of second messenger signaling, cyclic nucleotide regulation, and the therapeutic management of afflictions including cancer, cardiovascular disorders, and neurodegenerative conditions. Synonyms: Guanosine, adenylyl-(3'?5')-; 3'-Adenylic acid, 5'-ester with guanosine; Adenylyl-(3'?5')-guanosine; A-G; Adenosine, guanylyl-(5'?3')-; NSC 91554; ((2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl ((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl) hydrogen phosphate; 3'-O-(5'-Guanylyl)adenosine. Grades: ≥95%. CAS No. 3352-23-6. Molecular formula: C20H25N10O11P. Mole weight: 612.45. BOC Sciences
Aminoguanidine bicarbonate Aminoguanidine bicarbonate. Group: Biochemicals. Alternative Names: Guanylhydrazine hydrogencarbonate. Grades: Highly Purified. CAS No. 2582-30-1. Pack Sizes: 100g, 250g, 500g, 1Kg, 2Kg. Molecular Formula: CH6N4·H2CO3. US Biological Life Sciences. USBiological 6
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Asp(7)-Linaclotide Asp(7)-Linaclotde is an impurity of Linaclotide, which is a peptide agonist of guanylate cyclase 2C used for the treatment of abdominal pain in patients with irritable bowel syndrome (IBS) associated with constipation. Synonyms: L-cysteinyl-L-cysteinyl-L-alpha-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-α-aspartyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonyl-glycyl-L-cysteinyl-L-tyrosine (1-6),(2-10),(5-13)-tris(disulfide); H-Cys-Cys-Glu-Tyr-Cys-Cys-Asp-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH (Disulfide bridge: Cys1-Cys6, Cys2-Cys10, Cys5-Cys13); [7-Asp]-linaclotide; L-Tyrosine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-α-aspartyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (1?6),(2?10),(5?13)-tris(disulfide). CAS No. 1207977-38-5. Molecular formula: C59H78N14O22S6. Mole weight: 1527.71. BOC Sciences 2

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