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| Product | Description | |
|---|---|---|
| HDAC Inhibitor XIX, Compound 2 - CAS 6953-61-3 | The HDAC Inhibitor XIX, Compound 2, also referenced under CAS 6953-61-3, controls the biological activity of HDAC. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. |  |
| HDAC Inhibitor XVII ((E)-N-Hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamide, Histone Deacetylase Inhibitor XVII) | A cell-permeable N-hydroxycinnamide derivative that acts a highly potent and HDAC8-selective histone deacetylase inhibitor (IC50 = 27nM), displaying much reduced or little potency against HDAC1/3 (IC50 = 3.0uM), HDAC2/4/6/10/11 (IC50 >20uM), or total HDAC activity in HeLa nuclear extract (IC50 >10uM). Reported to preferentially inhibit the proliferation of human lung cancer cells CL1-5, H1299, and A549 (IC50 from 7 to 8uM), while being much less toxic to normal human lung IMR-90 cells (73% inhibition at 40uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??NO?, Primary Target IC50: 27nM. US Biological Life Sciences. |  Worldwide |
| HDAC Inhibitor XXIII, Tubastatin A | The HDAC Inhibitor XXIII, Tubastatin A controls the biological activity of HDAC. This small molecule/inhibitor is primarily used for Cell Structure applications. Group: Fluorescence/luminescence spectroscopy. | |
| HDAC Inhibitor XXIII, Tubastatin A (N-Hydroxy-4-(2-methyl-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-ylmethyl)benzamide, HCl) | A cell-permeable carbazolohydroxamate compound that acts as a highly potent, reversible and active-site zinc-binding HDAC6 inhibitor with excellent selectivity among other HDAC isozymes (IC50=0.015, 0.854, 16.4uM for HDAC6, HDAC8 and HDAC1, respectively) with no activity towards HDAC2, 3, 4, 7, 9, 10 and 11 (IC50>30uM). Shown to induce a-tubulin hyperacetylation at 2.5uM, and offer complete neuroprotection in primary cortical rat neuronal cells against homocysteic acid (HCA)-induced oxidative stress at 10uM with no noticeable neurotoxicity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| HDAC Inhibitor XXII, NCH51 - CAS 848354-66-5 | The HDAC Inhibitor XXII, NCH51, also referenced under CAS 848354-66-5, controls the biological activity of HDAC. This small molecule/inhibitor is primarily used for Cell Structure applications. Group: Fluorescence/luminescence spectroscopy. | |
| Apicidin, HDAC Inhibitor (Cyclo- N-O-methyl-L-tryptophanyl-Lisoleucinyl- Dpipecolinyl- L-2-amino-8-oxodecanoyl) | Cyclopeptide inhibitor of histone deactylases (HDACs). Inhibits HeLa cell proliferation (IC50=50-. Group: Biochemicals. Alternative Names: Cyclo- N-O-methyl-L-tryptophanyl-Lisoleucinyl- Dpipecolinyl- L-2-amino-8-oxodecanoyl. Grades: Highly Purified. CAS No. 183506-66-3. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| BML-210, HDAC Inhibitor (N1-(2-aminophenyl)-N8-. phenyloctanediamide) | A novel non-hydroxamic acid HDAC inhibitor. IC50=5-10uM (HeLa nuclear extract). Induces growth inhibition, proapoptotic and differentiation effects on human leukemia cell lines. Group: Biochemicals. Alternative Names: N1-(2-aminophenyl)-N8-phenyloctanediamide. Grades: Highly Purified. CAS No. 537034-17-6. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| HDAC3 Inhibitor | HDAC3 inhibitor is an allosteric inhibitor of histone deacetylase 3 (HDAC3; Ki = 0.16 nM, IC50s = 0.95 nM). HDAC3 inhibitors increase histone acetylation and restore normal transcriptional patterns. Treatment with inhibitors primarily targeting HDAC3, including some with additional activity on HDAC1, led to improvement in motor function and working memory in N-terminal transgenic HD mice. Synonyms: Histone Deacetylase 3 Inhibitor; (E) -3-Phenyl-N-[[4- (propylaminocarbamoyl) phenyl]methyl]prop-2-enamide. Grades: ≥98%. CAS No. 2044701-99-5. Molecular formula: C20H23N3O2. Mole weight: 337.4. |  |
| Hexyl-4-pentynoic Acid, HDAC Inhibitor. (2-(2-propynyl)octanoic acid (racemic), HPA) | Histone deacetylase (HDAC) inhibitor, IC50=13uM (1). More potent and robust than valproic acid at inducing histone hyperacetylation (600% at 50uM), HSP70 induction and protection against glutamate excitotoxicity in cultured neurons (2). Cell permeable. Group: Biochemicals. Alternative Names: 2-(2-propynyl)octanoic acid (racemic), HPA. Grades: Highly Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| 1, 2, 3, 4-Tetra hydro-N- hydroxy-2- [ (1- methyl -1H-pyrrol-2-yl ) carbonyl ] -6-isoquinolinecarboxamid e | HDAC6 Inhibitor is a potent and selective inhibitor of HDAC6 that poorly blocks other HDAC enzymes. HDAC6 is a predominantly cytoplasmic enzyme that targets α-tubulin, cortactin, and heat shock protein 90, as well as other substrates. Group: Biochemicals. Grades: Highly Purified. CAS No. 1259296-46-2. Pack Sizes: 500ug, 1mg. Molecular Formula: C16H17N3O3, Molecular Weight: 299.32. US Biological Life Sciences. | Worldwide |
| 1-(2,4-Dichlorobenzoyl)-1H-benzotriazole | Histone deacetylase (HDAC) inhibitors are able to interrupt cell cycle progression in transformed cell lines and may be explored as new clinical agents in cancer therapy. 1-(2,4-Dichlorobenzoyl)-1H-benzotriazole has been shown to suppress the biological effects induced by the HDAC inhibitor, Trichostatin A (T774710). Group: Biochemicals. Grades: Highly Purified. CAS No. 200626-61-5. Pack Sizes: 10mg, 25mg. Molecular Formula: C13H7Cl2N3O, Molecular Weight: 292.12. US Biological Life Sciences. | Worldwide |
| 1-(4-Hydroxyphenyl)-2-chloroethanol | 1-(4-Hydroxyphenyl)-2-chloroethanol is synthesized from 2-Chloro-1-(4-hydroxy-phenyl)-ethanone. 2-Chloro-1-(4-hydroxy-phenyl)-ethanone is a reagent that is used in the preparation of hydroxypyrimidine derivatives and their HDAC (histone deacetylases) inhibitory activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 4973-17-5. Pack Sizes: 250mg, 2.5g. Molecular Formula: C8H9ClO2, Molecular Weight: 172.61. US Biological Life Sciences. | Worldwide |
| 1-Naphthohydroxamic acid | 1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC 50 of 14 μM. 1-Naphthohydroxamic acid is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC 50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity [1] [2].1-Naphthohydroxamic acid can induce tubulin acetylation [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 6953-61-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-130538. |  |
| 1-Naphthohydroxamic acid | 1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM. 1-Naphthohydroxamic acid is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity.1-Naphthohydroxamic acid can induce tubulin acetylation. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 6953-61-3. Molecular formula: C11H9NO2. Mole weight: 187.19. Purity: >98.0%(T). Product ID: ACM6953613. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 1-Naphthohydroxamic Acid | 1-Naphthohydroxamic Acid is a potent HDAC inhibitor with efficacy against HDAC8, HDAC1 and HDAC6. Group: Biochemicals. Grades: Highly Purified. CAS No. 6953-61-3. Pack Sizes: 5mg, 10mg. Molecular Formula: C11H9NO2, Molecular Weight: 187.2. US Biological Life Sciences. | Worldwide |
| [2-(4-Fluorophenyl)thiazol-4-yl]methanol | [2-(4-Fluorophenyl)thiazol-4-yl]methanol is an intermediate used in preparation of azole compounds as histone deacetylase (HDAC) inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 885280-13-7. Pack Sizes: 100mg, 250mg. Molecular Formula: C10H8FNOS, Molecular Weight: 209.24. US Biological Life Sciences. | Worldwide |
| 2-Chloro-1-(4-hydroxy-phenyl)-ethanone | 2-Chloro-1-(4-hydroxy-phenyl)-ethanone is a reagent that is used in the preparation of hydroxypyrimidine derivatives and their HDAC (histone deacetylases) inhibitory activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 6305-04-0. Pack Sizes: 500mg, 5g. Molecular Formula: C8H7ClO2, Molecular Weight: 170.59. US Biological Life Sciences. | Worldwide |
| (2E)-N-Hydroxy-3-(5-methoxy[1,1':4',1''-terphenyl]-2-yl)-2-propenamide | (2E)-N-Hydroxy-3-(5-methoxy[1,1':4',1''-terphenyl]-2-yl)-2-propenamide, is a HDAC8 inhibitor with an IC50 of 27.2 nM. Group: Biochemicals. Grades: Highly Purified. CAS No. 1417997-93-3. Pack Sizes: 1mg, 5mg. Molecular Formula: C22H19NO3, Molecular Weight: 345.39. US Biological Life Sciences. | Worldwide |
| 2-Ethynylbiphenyl-13C6 | 2-Ethynylbiphenyl-13C6 is a reactant used in the preparation of labelled histone deacetylase (HDAC) inhibitors and EGFR tyrosine inhibitors. Group: Biochemicals. Alternative Names: 1-Ethynyl-2-phenylbenzene13C6; 2-Biphenylylacetylene 13C6. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 2-Formylcyclopropane-1-carboxylic Acid Ethyl Ester | 2-Formylcyclopropane-1-carboxylic Acid Ethyl Ester acts as a reagent for the design, synthesis and biological evaluation of first-in-class dual acting histone deacetylase (HDACs) and phosphodiesterase 5 (PDE5) inhibitors for treatment of Alzheimers disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 20417-61-2. Pack Sizes: 250mg, 500mg. Molecular Formula: C7H10O3, Molecular Weight: 142.15. US Biological Life Sciences. | Worldwide |
| 2-Hexyl-4-pentynoic acid | 2-hexyl-4-pentynoic acid is a derivative of valproic acid, an inhibitor of histone deacetylases (HDACs). It inhibits HDAC activity more potently (IC50 = 13 μM) than valproic acid (IC50 = 398 μM). Synonyms: 2-(prop-2-yn-1-yl)octanoic acid. Grades: ≥95%. CAS No. 96017-59-3. Molecular formula: C11H18O2. Mole weight: 182.3. | |
| 2-Oxo-1,2,3,4-tetrahydroquinoline-6-sulfonyl Chloride | 2-Oxo-1,2,3,4-tetrahydroquinoline-6-sulfonyl Chloride is a reactant used in the synthesis of pan-histone deacetylase (pan-HDAC) inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 66657-42-9. Pack Sizes: 100mg, 250mg. Molecular Formula: C9H8ClNO3S, Molecular Weight: 245.68. US Biological Life Sciences. | Worldwide |
| 3,3'-Diindolylmethane (3,3-Methylenediindole, DIM) | Diindolylmethane (DIM) is a natural compound present in food plants of the Brassica genus, including broccoli, cabbage, Brussels sprouts, cauliflower and kale. Displays antitumor and proapoptotic properties in animal and in in vitro models of cancer. Also acts a selective and potent inhibitor of cancer stem cells, and HDAC activity in prostate cancer cells. Recently, it has been shown that DIM induces apoptosis in ovarian cancer cells by inhibiting JAK2/STAT3. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg, 1g. US Biological Life Sciences. | Worldwide |
| 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline | 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline (Compound 11 and 15) is a building block and synthetic intermediate, which can be used as a precursor in the synthesis of receptor tyrosine kinase (RTK) inhibitors, dual RTK and histone deacetylase (HDAC) inhibitors, and anticancer agents. 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline can also be used to synthesize EGFR inhibitors, including Erlotinib (HY-50896), with antiproliferative activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 183322-18-1. Pack Sizes: 50 mg; 100 mg; 500 mg. Product ID: HY-W007977. | |
| 4-Iodo-SAHA | 4-Iodo-SAHA is a hydrophobic derivative of the class I and class II histone deacetylase (HDAC) inhibitor SAHA. Synonyms: N1-hydroxy-N8-(4-iodophenyl)octanediamide. Grades: ≥98%. CAS No. 1219807-87-0. Molecular formula: C14H19IN2O3. Mole weight: 390.2. | |
| 4-Phenylbutyric acid | 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4-PBA; Benzenebutyric acid. CAS No. 1821-12-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-A0281. | |
| 4SC-202 | 4SC-202 is a selective and potent, orallly available inhibitor of histone deacetylases (HDAC) specific for class 1 HDAC isoenzymes, with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. 4SC-202 also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). In addition, 4SC-202 shows a broad anti-proliferative activity towards human cancer cell lines with a mean IC50 of 0.7 μM. Synonyms: 4SC202; 4SC-202; 4SC 202; domatinostat; (E)-N-(2-aminophenyl)-3-(1-((4-(1-methyl-1H-pyrazol-4-yl)phenyl)sulfonyl)-1H-pyrrol-3-yl)acrylamide. CAS No. 910462-43-0. Molecular formula: C23H21N5O3S. Mole weight: 447.51. | |
| 4SC-202 Tosylate | 4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity. HDAC inhibitor 4SC-202 selectively binds to and inhibits class I HDACs leading to an accumulation of highly acetylated histones.This may inhibit tumor cell proliferation in susceptible tumor cells. HDACs, upregulated in many tumor types, are a class of enzymes that deacetylate chromatin histone proteins. Synonyms: 4SC-202; 4SC 202; 4SC202. Grades: 0.98. CAS No. 1186222-89-8. Molecular formula: C30H29N5O6S2. Mole weight: 619.711. | |
| 5-Phenylpentan-2-one | 5-Phenylpentan-2-one is a potent histone deacetylases (HDACs) inhibitor. 5-Phenylpentan-2-one can be used for urea cycle disorder research. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-Pentanone, 5-phenyl-, 5-Phenylpentan-2-one, Methyl 3-phenylpropyl ketone, 5-PHENYL-2-PENTANONE, NSC167086, CID16701, EINECS 218-794-4, ZINC01659989, AI3-11039, 2235-83-8. Product Category: Inhibitors. Appearance: Liquid. CAS No. 2235-83-8. Molecular formula: C11H14O. Mole weight: 162.228260 [g/mol]. Purity: 0.96. IUPACName: 5-phenylpentan-2-one. Canonical SMILES: CC(=O)CCCC1=CC=CC=C1. Density: 0.96g/cm³. ECNumber: 218-794-4. Product ID: ACM2235838. Alfa Chemistry ISO 9001:2015 Certified. | |
| 7,4'-Dihydroxyflavone | 7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor ( IC 50 =0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)?paradoxical adverse effects on eotaxin production [1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC 50 value of 1.4 μM [1]. Uses: Scientific research. Group: Natural products. CAS No. 2196-14-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N2609. | |
| Abexinostat | Abexinostat, also known as PCI-24781 or CRA-024781, is a novel, broad-spectrum hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. Abexinostat inhibits several isoforms of HDAC, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling. Synonyms: CRA-024781; CRA 024781; CRA024781; PCI-24781; PCI24781; PCI 24781. Grades: 98%. CAS No. 783355-60-2. Molecular formula: C21H23N3O5. Mole weight: 397.431. | |
| Abexinostat | Abexinostat (CRA 024781) is a novel pan- HDAC inhibitor mostly targeting HDAC1 with K i of 7 nM. Abexinostat also inhibits metallo-β-lactamase domain-containing protein?2 ( MBLAC2 ) hydrolase activity with an EC 50 below 10 nM [1] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CRA 024781; PCI-24781. CAS No. 783355-60-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10990. | |
| ACY-738 | ACY-738 is a potent and selective HDAC6 inhibitor with improved brain bioavailability. ACY-738 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs. Synonyms: ACY-738; ACY 738; ACY738. Grades: 98%. CAS No. 1375465-91-0. Molecular formula: C14H14N4O2. Mole weight: 270.29. | |
| ACY-775 | ACY-775 is a selective Histone Deacetylase 6 (HDAC6) inhbiitor with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs. ACY-775 has the antidepressant-like properties of other HDAC inhibitors. Uses: Antidepressant. Synonyms: ACY-775; ACY 775; ACY775; 2-((1-(3-Fluorophenyl)cyclohexyl)amino)-N-hydroxypyrimidine-5-carboxamide. Grades: 95%. CAS No. 1375466-18-4. Molecular formula: C17H19FN4O2. Mole weight: 330.36. | |
| AES-350 | AES-350 is an effective and orally active HDAC6 inhibitor with IC50 and Ki of 0.0244 μM and 0.035 μM, respectively. AES-350 shows higher HDAC isoform selectivity, higher MV4-11 cell cytotoxicity, improved treatment window and more effective absorption through cells and lipid membranes. Synonyms: Tert-Butylbenzamido Hydroxylbenzamide. Grades: 98%. CAS No. 847249-57-4. Molecular formula: C18H20N2O3. Mole weight: 312.4. | |
| AN-7 | AN-7 is a novel histone deacetylase inhibitor (HDACI) with anticancer activity in several cell lines. Synonyms: 3-(5-[1,2]dithiolan-3yl-pentanoylamino)-propyl]-amide. CAS No. 691410-93-2. Molecular formula: C19H34N2O2S4. Mole weight: 450.73. | |
| APHA Compound 8 | APHA Compound 8 is a synthetic HDAC (histone deacetylase) inhibitor, which is in the same structural class as SAHA. The IC50 for mouse HDAC1 is 0.5 μM. It induces histone hyperacetylation, growth inhibition, and terminal cell differentiation. Synonyms: MC-1353; MC1353; MC 1353; APHA-8; APHA Compound 8; Aroyl pyrrole hydroxy amide #8; APHA 8; APHA8. Grades: ≥98%. CAS No. 676599-90-9. Molecular formula: C16H16N2O3. Mole weight: 284.3. | |
| Apicidin | Apicidin (OSI 2040) is a fungal metabolite, acts as an orally active histone deacetylase 7/8 ( HDAC7/8 ) inhibitor, with antiparasitic activity and a broad spectrum antiproliferative activity. Apicidin can be used for cancer research [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: OSI 2040. CAS No. 183506-66-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N6735. | |
| AR-42 | AR-42 (HDAC-42; OSU-HDAC42) is a potent, orally bioavailable pan- HDAC inhibitor ( IC 50 =16 nM). AR-42 induces growth inhibition, cell-cycle arrest, apoptosis , and activation of caspases-3/7. AR-42 promotes hyperacetylation of H3, H4, and alpha-tubulin, and up-regulation of p21. AR-42 shows cytotoxicity against various human cancer cell lines [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HDAC-42; OSU-HDAC42. CAS No. 935881-37-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13265. | |
| AR-42 | AR-42 is an orally available, broad-spectrum deactylation inhibitor of both histone and non-histone proteins which play an important role in the regulation of gene expression, cell growth and survival. In preclinical studies, AR-42 has demonstrated greater potency and activity in solid and liquid tumors when compared to vorinostat and other deacetylase inhibitors. AR-42 is currently being studied in an investigator-initiated Phase I/IIa clinical study in adult patients with relapsed or refractory multiple myeloma, chronic lymphocytic leukemia or lymphoma. Synonyms: HDAC-42; HDAC42; HDAC 42; OSU-HDAC-42; OSU HDAC 42; AR-42; AR42; AR 42. Grades: 98%. CAS No. 935881-37-1. Molecular formula: C18H20N2O3. Mole weight: 312.37. | |
| Autophagy Compound Library | A unique collection of 1248 compounds with defined autophagy-inducing or -inhibitory activity for research in autophagy, high throughput screening (HTS) and high content screening (HCS) for new drugs; - Bioactivity and safety confirmed by pre-clinical research and clinical trials; - Targets include Autophagy inducers, Autophagy inhibitors, Proteasome, HIF, HDAC, Aurora Kinase, E3 Ligase, mTOR, etc; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L3200. Categories: Autophagy Compounds Libraries. |  |
| Bakkenolide A | Bakkenolide A is a natural product extracted from Petasites tricholobus. Bakkenolide A inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related signaling pathways. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 19906-72-0. Molecular formula: C15H22O2. Mole weight: 234.33. Canonical SMILES: O=C([C@@]12C[C@@]3([H])CCC[C@H](C)[C@@]3(C)C2)OCC1=C. Product ID: ACM19906720. Alfa Chemistry ISO 9001:2015 Certified. | |
| Belinostat | Belinostat is a hydroxamic acid-type histone deacetylase (HDAC) inhibitor. Belinostat targets HDAC enzymes to inhibit tumor cell proliferation and angiogenesis, induce apoptosis and promote cellular differentiation. Uses: Antineoplastic agents. Synonyms: Belinostat; PXD 101; Beleodaq; PDX101; PX 105684; PXD-101; PXD101; (E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide. CAS No. 414864-00-9. Molecular formula: C15H14N2O4S. Mole weight: 318.347. | |
| Belinostat | Belinostat (PXD101; PX105684) is a potent HDAC inhibitor with an IC 50 of 27 nM in HeLa cell extracts. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PXD101; PX105684. CAS No. 866323-14-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10225. | |
| BG45 | BG45 is a class I HDAC inhibitor with IC50 of 289 nM, 2.0 μM, 2.2 μM and >20 μM for HDAC3, HDAC1, HDAC2, and HDAC6 in cell-free assays, respectively. Synonyms: BG45; BG-45; BG 45. Grades: 98%. CAS No. 926259-99-6. Molecular formula: C11H10N4O. Mole weight: 214.22. | |
| Biphenyl-4-sulfonyl chloride | Biphenyl-4-sulfonyl chloride is a HDAC inhibitor with synthetic applications in palladium-catalyzed desulfitative C-arylation. Synonyms: 4-phenylbenzenesulfonyl chloride. Grades: ≥ 95 %. CAS No. 1623-93-4. Molecular formula: C12H9ClO2S. Mole weight: 252.72. | |
| BML-210 | BML-210, also known as CAY10433, is HDAC inhibitor. BML-210 induces growth inhibition and apoptosis and regulates HDAC and DAPC complex expression levels in cervical cancer cells. BML-210 can inhibit cell growth and induce apoptosis in cervical cancer cells, what correlates with down-regulation of HDAC class I and II and changes in the DAPC expression levels. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BML-210; BML 210; BML210; CAY10433; CAY-10433; CAY 10433. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 537034-17-6. Molecular formula: C20H25N3O2. Mole weight: 339.44. Purity: >98%. IUPACName: N-(2-aminophenyl)-N'-phenyl-octanediamide. Canonical SMILES: O=C(NC1=CC=CC=C1N)CCCCCCC(NC2=CC=CC=C2)=O. Product ID: ACM537034176. Alfa Chemistry ISO 9001:2015 Certified. | |
| BML-210 | BML-210 is a Histone deacetylase (HDAC) inhibitor (IC50 = 87 μM), inducingchanges in gene expression profile. Uses: A histone deacetylase (hdac) inhibitor. Synonyms: BML-210; BML 210; BML210; CAY10433; CAY-10433; CAY 10433N1-(2-aminophenyl)-N8-phenyloctanediamide; N-(2-aminophenyl)-N'-phenyl-octanediamide. Grades: ≥98%. CAS No. 537034-17-6. Molecular formula: C20H25N3O2. Mole weight: 339.43. | |
| Bocodepsin | Bocodepsin (OKI-179) is an orally active and selective HDAC inhibitor, with antitumor activity. Bocodepsin can be used for suppression on solid tumor and hematologic malignancies [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: OKI-179. CAS No. 1834513-65-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-156602. | |
| BPR1J-340 | BPR1J-340 is a potent and selective FLT3 inhibitor with potential anticancer activity. BPR1J-340 was identified as a novel potent FLT3 inhibitor by biochemical kinase activity (IC50 approximately 25 nM) and cellular proliferation (GC50 approximately 5 nM) assays. BPR1J-340 inhibited the phosphorylation of FLT3 and STAT5 and triggered apoptosis in FLT3-ITD(+) AML cells. The pharmacokinetic parameters of BPR1J-340 in rats were determined. BPR1J-340 also demonstrated pronounced tumor growth inhibition and regression in FLT3-ITD(+) AML murine xenograft models. The combination treatment of the HDAC inhibitor vorinostat (SAHA) with BPR1J-340 synergistically induced apoptosis via Mcl-1 down-regulation in MOLM-13 AML cells, indicating that the combination of selective FLT3 kinase inhibitors and HDAC inhibitors could exhibit clinical benefit in AML therapy. Synonyms: BPR1J 340; BPR1J340. Grades: 98%. CAS No. 1395051-72-5. Molecular formula: C29H34N8O3. Mole weight: 542.63. | |
| BRD3308 | BRD3308 is a highly selective HDAC3 inhibitor with IC50 of 54 nM. BRD3308 inhibits pancreatic β-cell apoptosis induced by inflammatory cytokines or glycolipid toxic stress, and increases the release of functional insulin. BRD3308 activates HIV-1 transcription and destroys the HIV-1 incubation period. Synonyms: 4-Acetylamino-N-(2-Amino-4-Fluorophenyl)-Benzamide; CHEMBL4293858; SCHEMBL15551809; BDBM178100. Grades: 98%. CAS No. 1550053-02-5. Molecular formula: C15H14FN3O2. Mole weight: 287.29. | |
| BRD 4354 | BRD 4354 is an HDAC5 and HDAC9 inhibitor (IC50 = 0.85 and 1.88 μM, respectively) displaying >20-fold selectivity for HDAC5/9 over HDAC1/2/3. It also weakly inhibits HDAC4, HDAC6, HDAC7 and HDAC8 (IC50 values are 3.88 - 13.8 μM). Synonyms: BRD4354; BRD 4354; BRD-4354; 5-Chloro-7-[(4-ethyl-1-piperazinyl)-3-pyridinylmethyl]-8-quinolinol. Grades: ≥98% by HPLC. CAS No. 315698-07-8. Molecular formula: C21H23ClN4O. Mole weight: 382.89. | |
| BRD4884 | BRD4884 is a selective HDAC inhibitor with IC50 values of 29 nM, 62 nM, and 1.09 μM for HDAC1, 2, and 3. It possesses preferential binding kinetics with seven-fold longer half-life. BRD4884 crosses the blood brain barrier and has been evaluated in CK-p25 mice, a mouse model of neurodegeneration. It acts by enhancing the learning and memory processes. Synonyms: BRD-4884; BRD 4884. Grades: ≥98%. CAS No. 1404559-91-6. Molecular formula: C18H19FN2O2. Mole weight: 314.4. | |
| BRD6688 | BRD6688 is an HDAC inhibitor with IC50 values of 21 nM, 100 nM, and 11.48 μM for HDAC1, 2, and 3, respectively. It possesses preferential binding kinetics with six-fold extended half-life on HDAC2 compared to HDAC1. It crosses the blood brain barrier and has been shown to rescue the memory defects associated with p25 induced neurodegeneration in contextual fear conditioning in a CK-p25 mouse model of neurodegeneration. Synonyms: BRD-6688; BRD 6688. Grades: ≥98%. CAS No. 1404562-17-9. Molecular formula: C16H18N4O. Mole weight: 282.3. | |
| BRD73954 | BRD73954 ia a potent and selective HDAC inhibitor with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively. Synonyms: BRD73954; BRD-73954; BRD 73954. Grades: >98%. CAS No. 1440209-96-0. Molecular formula: C16H16N2O3. Mole weight: 284.31. | |
| BRD 9757 | BRD9757 is a potent and selective histone deacetylases 6 (HDAC6) inhibitor with IC50 of 30 nM. It displays selectivity for HDAC6 over Class I HDACS (>20-fold) and Class II HDACs (>400-fold). Synonyms: N-Hydroxy-1-cyclopentene-1-carboxamide; BRD9757; BRD-9757. Grades: ≥98%. CAS No. 1423058-85-8. Molecular formula: C6H9NO2. Mole weight: 127.14. | |
| Bufexamac | Bufexamac is a selective ?b HDAC (HDAC6, HDAC10) and LTA4H dual inhibitor, with K d s of 0.53 μM and 0.22 μM for HDAC6 and HDAC10. Bufexamac is a nonsteroida anti-inflammatory drug [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Bufexamic acid. CAS No. 2438-72-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-B0494. | |
| Bufexamac | Bufexamac is a specific inhibitor of class IIB histone deacetylases (HDAC6 and HDAC10). Bufexamac is a non-steroidal anti-inflammatory drug used topically as well as rectally. Formulations containing Bufexamac is used by many patients with eczematous disorders as an alternative to topical corticosteroids. Group: Biochemicals. Alternative Names: 4-Butoxy-N-hydroxy Benzene acetamide; 2- (p-Butoxyphenyl) acetohydroxamic Acid; 4-Butoxyphenylacet hydroxamic Acid; Anderm; Bufexamic Acid; CP 1044J3; Droxarol; Droxaryl; Feximac; Flogocid; Flogocid N plastigel; Malipuran; Mofenar; Norfemac; Parfenac; Parfenal; Trolab; p-Butoxyphenylacet hydroxamic Acid; p-Butoxyphenylaceto hydroxamic Acid. Grades: Highly Purified. CAS No. 2438-72-4. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| Carbamazepine | Carbamazepine is an orally active pressure-sensitive sodium ion channel blocker with an IC 50 of 131 μM. Carbamazepine blocks voltage gated Na + , Ca 2+ , and K + channels, and is also a HDAC inhibitor ( IC 50 : 2 μM). Carbamazepine is an anticonvulsant and can be used for research of epilepsy and neuropathic pain [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CBZ; NSC 169864. CAS No. 298-46-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0246. | |
| CAY10398 | CAY10398 is an inhibitor of histone deacetylase (HDAC1) with an IC50 value of 10 μM. It has equivalent selectivity and is much more cost-effective for the inhibition of HDAC. The deacetylation of histones by HDAC is associated with transcriptional silencing. Synonyms: MD 85; PX 089274. Grades: ≥98%. CAS No. 193551-00-7. Molecular formula: C15H23N3O3. Mole weight: 293.4. | |
| CAY10603 | CAY10603 is a potent and selective inhibitor of HDAC6 with IC50 of 2 pM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively. Uses: Histone deacetylase inhibitors. Synonyms: CAY10603; CAY-10603; CAY 10603. Grades: >98%. CAS No. 1045792-66-2. Molecular formula: C22H30N4O6. Mole weight: 446.5. | |
| CAY10683 | Santacruzamate A (CAY10683) is a potent and selective HDAC inhibitor with IC50 of 119 pM for HDAC2, >3600-fold selectivity over other HDACs. Uses: Histone deacetylase inhibitors. Synonyms: CAY10683; CAY-10683; CAY 10683; Santacruzamate A. Grades: >98%. CAS No. 1477949-42-0. Molecular formula: C15H22N2O3. Mole weight: 278.35. | |
| CAY10721 | Sirtuins (SIRTs) are a family of proteins that regulate cellular health. Sirtuins play a key role in regulating cellular homeostasis. SIRT1 Activator 3 is a member of the sirtuins (SIRTs), which is a distinctive class of trichostatin A-insensitive lysyl-deacetylases. CAY10721 is an inhibitor of SIRT3. It is a class III HDAC (39% SIRT3 inhibition at 200 μM). Synonyms: CAY 10721; CAY-10721. Grades: ≥98%. CAS No. 848688-62-0. Molecular formula: C18H13N3O3S. Mole weight: 351.4. | |
| CAY10722 | Sirtuins (SIRTs) are a family of proteins that regulate cellular health. Sirtuins play a key role in regulating cellular homeostasis. SIRT1 Activator 3 is a member of the sirtuins (SIRTs), which is a distinctive class of trichostatin A-insensitive lysyl-deacetylases. CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 μM). Synonyms: CAY 10722; CAY-10722. Grades: ≥98%. CAS No. 388086-13-3. Molecular formula: C21H14Cl2N2O2. Mole weight: 397.3. | |
| CBHA | Histone deacetylase (HDAC) inhibitors hyperacetylate histones and increase transcriptional activity in selected genes. CBHA is a cell-permeable second generation hybrid polar agent that acts as a HDAC inhibitor. It exhibits ID50 values of 0.01 and 0.07 μM in vitro for HDAC1 and HDAC3, respectively. CBHA also induces apoptosis in nine different neuroblastoma cell lines in culture. Uses: Histone deacetylase inhibitors. Synonyms: Histone Deacetylase Inhibitor II; m-Carboxycinnamic acid bis-hydroxamide. Grades: ≥98%. CAS No. 174664-65-4. Molecular formula: C10H10N2O4. Mole weight: 222.2. | |
| CG200745 | CG200745 is a novel hydroxamate-based pan-histone deacetylase inhibitor (HDACI). Like other inhibitors, CG200745 has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. CG200745 inhibited deacetylation of histone H3 and tubulin as much as vorinostat and belinostat did. CG200745 also inhibited growth of prostate cancer cells, increased sub-G1 population, and activated caspase-9, -3 and -8 in LNCaP, DU145 and PC3 cells. These results indicate that CG200745 induces apoptosis. The preclinical results show that combination treatment with docetaxel and new HDACI, CG200745, potentiated anti-tumor effect in hormone-refractory prostate cancer (HRPC) cells via activation of apoptosis. Synonyms: Ivaltinostat; CG-200745; CG-2; (E)-N1-(3-(dimethylamino)propyl)-N8-hydroxy-2-((naphthalen-1-yloxy)methyl)oct-2-enediamide. CAS No. 936221-33-9. Molecular formula: C24H33N3O4. Mole weight: 427.55. | |
| Chidamide | Chidamide, also known as CS055 and HBI-8000, is an orally bioavailable benzamide type inhibitor of histone deacetylase (HDAC) isoenzymes 1, 2, 3 and 10, with potential antineoplastic activity. Chidamide selectively binds to and inhibits HDAC leading to an increase of acetylation levels of histone protein H3. This agent also inhibits the expression of signaling kinases in the PI3K/Akt and MAPK/Ras signaling pathways and may result in cell cycle arrest and the induction of tumor cell apoptosis. This may inhibit tumor cell proliferation in susceptible tumor cells. HDACs, a class of enzymes that deacetylate chromatin histone proteins, are upregulated in many tumor types and play key roles in gene expression. Compared to some other benzamide type HDAC inhibitors, chidamide is more stable, more resistant to degradation and has a longer half-life. Synonyms: CS055; CS-055; CS 055; HBI-8000; HBI 8000; HBI8000; N-(2-amino-5-fluorophenyl)-4-[[[1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-benzamide. CAS No. 743420-02-2. Molecular formula: C22H19FN4O2. Mole weight: 390.418. | |
| Chlamydocin | Chlamydocin is a highly potent HDAC inhibitor produced by the strain of Diheterospora chlamydosporia. The inhibitory activity of mouse mast cell cancer cells was stronger than that of actinomycin D, but it could be inactivated by plasma, so the anti-tumor effect in vivo was low. Synonyms: Cyclo[2-methylalanyl-L-phenylalanyl-D-prolyl-(aS,2S)-a-amino-h-oxo-2-oxiraneoctanoyl]. Grades: 95%. CAS No. 53342-16-8. Molecular formula: C28H38N4O6. Mole weight: 526.62. | |
| CHR-3996 | CHR-3996 is an orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor CHR-3996 inhibits HDAC, resulting in an accumulation of highly acetylated histones, the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes; these events may result in the inhibition of tumor cell division and the induction of tumor cell apoptosis. This agent may upregulate HSP70 and downregulate anti-apoptotic Bcl-2 proteins more substantially than some first-generation HDAC inhibitors. HDACs, upregulated in many tumor cell types, are a family of metalloenzymes responsible for the deacetylation of chromatin histone proteins. Synonyms: CHR3996; CHR 3996; VRx-3996; VRx3996; VRx 3996; Nanatinostat; Tractinostat. CAS No. 1235859-13-8. Molecular formula: C21H20FN5O2. Mole weight: 393.42. | |
| CI-994 (4-(Acetylamino)-N-(2-aminophenyl)benzamide, Acetyldinaline, Gö 5549, PD 123654) | Cell-permeable. A histone deacetylase (HDAC) inhibitor (Ki values are 0.41, 0.75, >100 and >100um for HDAC1, HDAC3, HDAC6 and HDAC8 respectively). Displays significant antitumor activity in vitro and in vivo against a broad spectrum of murine and human tumor models. Group: Biochemicals. Grades: Highly Purified. CAS No. 112522-64-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
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