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| Product | Description | |
|---|---|---|
| Hepcidin | Hepcidin, a liver-derived peptide hormone, is a key regulator of systemic iron homeostasis, and its unbalanced production contributes to the pathogenesis of a spectrum of iron disorders. Hepcidin has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. It is active against the fungus C. albicans. Synonyms: Liver-expressed antimicrobial peptide 1. |  |
| Hepcidin-1 | Hepcidin-1 is isolated from Salmo salar. Hepcidin-1 seems to act as a signaling molecule involved in the maintenance of iron homeostasis. It seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. Hepcidin-1 may also have antimicrobial activity. | |
| Hepcidin-1 (mouse) | Two kinds of hepcidin are found in mice. Hepcidin-1, a homolog of human Hepcidin-25 in serum, may be involved in murine brain iron metabolism. Hepcidin-2 is a pentapeptide with different sequences in urine. Synonyms: H-Asp-Thr-Asn-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Lys-Cys-Cys-Asn-Asn-Ser-Gln-Cys-Gly-Ile-Cys-Cys-Lys-Thr-OH (Disulfide bridge: Cys7-Cys23, Cys10-Cys22, Cys11-Cys19, Cys13-Cys14); L-alpha-aspartyl-L-threonyl-L-asparagyl-L-phenylalanyl-L-prolyl-L-isoleucyl-L-cysteinyl-L-isoleucyl-L-phenylalanyl-L-cysteinyl-L-cysteinyl-L-lysyl-L-cysteinyl-L-cysteinyl-L-asparagyl-L-asparagyl-L-seryl-L-glutaminyl-L-cysteinyl-glycyl-L-isoleucyl-L-cysteinyl-L-cysteinyl-L-lysyl-L-threonine (7->23),(10->22),(11->19),(13->14)-tetrakis(disulfide); L-α-Aspartyl-L-threonyl-L-asparaginyl-L-phenylalanyl-L-prolyl-N-[(1R, 4R, 7S, 10S, 13R, 18R, 21R, 24S, 30R, 33S, 36S, 39S, 42S, 45R, 50R, 53S)-53-(4-aminobutyl)-18-{[(2S)-6-amino-1-{[(1S, 2R)-1-carboxy-2-hydroxypropyl]amino}-1-oxo-2-hexanyl]carbamoyl}-39, 42-bis(2-amino-2-oxoethyl)-33-(3-amino-3-oxopropyl)-7-benzyl-10, 24-di[(2S)-2-butanyl]-36-(hydroxymethyl)-3, 6, 9, 12, 20, 23, 26, 29, 32, 35, 38, 41, 44, 52, 55, 60-hexadecaoxo-15, 16, 47, 48, 57, 58, 63, 64-octathia-2, 5, 8, 11, 19, 22, 25, 28, 31, 34, 37, 40, 43, 51, 54, 61-hexadecaazatetracyclo[28.25.4.44, 21.245, 50]pentahexacont-13-yl]-L-isoleucinamide. Grades: ≥95%. CAS No. 1676104-75-8. Molecular formula: C111H169N31O35S8. Mole weight: 2754.28. | |
| Hepcidin-2 | Hepcidin-2 is isolated from Mus musculus. It seems to act as a signaling molecule involved in the maintenance of iron homeostasis. | |
| Hepcidin-22 (human) | Hepcidin-22 (human) is an inactive degradation product of Hepcidin-25 found in human urine. Synonyms: H-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-OH (Disulfide bridge: Cys4-Cys10, Cys7-Cys20, Cys8-Cys19, Cys11-Cys16, air oxidized); L-phenylalanyl-L-prolyl-L-isoleucyl-L-cysteinyl-L-isoleucyl-L-phenylalanyl-L-cysteinyl-L-cysteinyl-glycyl-L-cysteinyl-L-cysteinyl-L-histidyl-L-arginyl-L-seryl-L-lysyl-L-cysteinyl-glycyl-L-methionyl-L-cysteinyl-L-cysteinyl-L-lysyl-L-threonine (4->10),(7->20),(8->19),(11->16)-tetrakis(disulfide). Grades: ≥95%. CAS No. 342790-22-1. Molecular formula: C99H151N29O25S9. Mole weight: 2436.06. | |
| Hepcidin-24 (human) | Hepcidin-24, an excellent substitute for biotinylated or heavy isotope-labeled hepcidin-25, is used as an internal reference in the determination of Hep-25 by mass spectrometry-based methods, for example in human serum or urine. Synonyms: H-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-OH (Disulfide bridge: Cys6-Cys22, Cys9-Cys12, Cys10-Cys18, Cys13-Cys21, air oxidized); des-Asp1-Hepcidin-24. Grades: ≥95%. Molecular formula: C109H165N33O28S9. Mole weight: 2674.31. | |
| Hepcidin-25 (human) | Hepcidin-25 (hepatic bactericidal protein), also known as LEAP-1 (liver-expressed antimicrobial peptide), is found independently in human blood ultrafiltration and urine. It is mainly expressed in liver and belongs to a new family of small vertebrate antimicrobial peptides that contain 8 cysteine residues and has obvious antibacterial and antifungal activities. Hepcidin is the main human iron regulatory hormone, which can bind to iron exporter ferroportin and induce its internalization and degradation, thus blocking iron efflux from cells. Uses: Anti-infective agents. Synonyms: LEAP-1 (human); H-Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-OH (Disulfide bridge: Cys7-Cys23, Cys10-Cys13, Cys11-Cys19, Cys14-Cys22); L-alpha-aspartyl-L-threonyl-L-histidyl-L-phenylalanyl-L-prolyl-L-isoleucyl-L-cysteinyl-L-isoleucyl-L-phenylalanyl-L-cysteinyl-L-cysteinyl-glycyl-L-cysteinyl-L-cysteinyl-L-histidyl-L-arginyl-L-seryl-L-lysyl-L-cysteinyl-glycyl-L-methionyl-L-cysteinyl-L-cysteinyl-L-lysyl-L-threonine (7->23),(10->13),(11->19),(14->22)-tetrakis(disulfide); Hepcidin Hepc25 (human); Hepcidin-25. Grades: ≥95% by HPLC. CAS No. 1356390-47-0. Molecular formula: C113H170N34O31S9. Mole weight: 2789.35. | |
| Hepcidin-25 (human) trifluoroacetate salt | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Hepcidin 3 | Hepcidin 3 was found in Epinephelus moara. It has antimicrobial activity. | |
| Hepcidin 5 | Hepcidin 5 was found in Epinephelus moara. It has antimicrobial activity. | |
| Hepcidin antimicrobial peptide 1 | Hepcidin antimicrobial peptide 1 is produced by Danio rerio. | |
| Hepcidin-like antimicrobial peptide precursor | Hepcidin-like antimicrobial peptide precursor is an antibacterial peptide isolated from Channa argus (snakehead). Synonyms: Leu-Glu-Glu-Ala-Gly-Ser-Asn-Asp-Thr-Pro-Val-Ala-Ala-His-Gln-Glu-Met-Ser-Thr-Glu-Ser-Trp-Met-Met-Pro-Asn-His-Ile-Arg-Gln-Lys-Arg-Gln-Ser-His-Ile-Ser-Leu-Cys-Arg-Tyr. | |
| Hepcidin TH1-5 | Hepcidin TH1-5 has been demonstrated to be effective against Nervous necrosis virus infection in medaka (Oryzias latipes). | |
| hepcidin TH2-3 | Hepcidin TH2-3, a synthetic 20-mer antimicrobial peptide, specifically inhibited human fibrosarcoma cell (HT1080 cell line) proliferation and migration. | |
| Biotinyl-Hepcidin-25 (human) | Synonyms: Biotinyl-Hepc25 (human); Biotinyl-Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-OH (Disulfide bridge: Cys7-Cys23, Cys10-Cys13, Cys11-Cys19, Cys14-Cys22); Biotinyl-Hepc25 (human); N-biotinyl-L-alpha-aspartyl-L-threonyl-L-histidyl-L-phenylalanyl-L-prolyl-L-isoleucyl-L-cysteinyl-L-isoleucyl-L-phenylalanyl-L-cysteinyl-L-cysteinyl-glycyl-L-cysteinyl-L-cysteinyl-L-histidyl-L-arginyl-L-seryl-L-lysyl-L-cysteinyl-glycyl-L-methionyl-L-cysteinyl-L-cysteinyl-L-lysyl-L-threonine (7->23),(10->13),(11->19),(14->22)-tetrakis(disulfide). Grades: ≥95%. CAS No. 1815618-07-5. Molecular formula: C123H184N36O33S10. Mole weight: 3015.65. | |
| EC-hepcidin3 | EC-hepcidin3, a new four-cysteine hepcidin isoform gene, was cloned from the marine-cultured orange-spotted grouper (Epinephelus coioides). | |
| 2-(1a-methyl-6-oxo-3-phenoxy-1,1a,6,6a-tetrahydroindeno[1,2-b]azirine-6a-carboxamido)acetic acid | 2-(1a-methyl-6-oxo-3-phenoxy-1,1a,6,6a-tetrahydroindeno[1,2-b]azirine-6a-carboxamido)acetic acid is an impurity of Roxadustat. Roxadustat is a hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI). It promotes coordinated erythropoiesis through increasing endogenous erythropoietin, improving iron availability, and reducing hepcidin. Synonyms: (1a-methyl-6-oxo-3-phenoxy-1,1a,6,6a-tetrahydroindeno[1,2-b]azirine-6a-carbonyl)glycine; Rosastat impurity 02. CAS No. 2301113-15-3. Molecular formula: C19H16N2O5. Mole weight: 352.35. | |
| AS-hepc2 | AS-hepc2 is an antimicrobial peptide produced by Acanthopagrus schlegelii (Black porgy). It has antimicrobial activity. Synonyms: Hepcidin AS-hepc2; Ser-Pro-Ala-Gly-Cys-Arg-Phe-Cys-Cys-Gly-Cys-Cys-Pro-Asn-Met-Arg-Gly-Cys-Gly-Val-Cys-Cys-Arg-Phe (Disulfide bridge: Cys5-Cys22, Cys8-Cys21, Cys9-Cys18, Cys11-Cys12). Grades: >98%. Molecular formula: C98H148N34O27S9. Mole weight: 2523.01. | |
| Ferroportin-IN-1 | Ferroportin-IN-1 is a ferroportin inhibitor extracted from patent WO2020123850A1 compound 23. Ferroportin-IN-1 can be used for the research of diseases caused by a lack of hepcidin or iron metabolism disorders [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2443432-65-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-145965. |  |
| Guanosine 5'-diphosphate disodium salt | Guanosine 5'-diphosphate (GDP) disodium salt, a purine nucleoside diphosphate, is interconverted to guanosine by the action of exonucleotidase and phosphorylation of nucleoside to guanine. Guanosine 5'-diphosphate disodium salt activates adenosine 5'-triphosphate-sensitive K + channel and is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors (GPCR). Guanosine 5'-diphosphate disodium salt is a potential iron mobilizer, which prevents the Hepcidin (HY-P70400)- ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Elevated levels of guanosine 5-diphosphate are associated with the pathogenesis of neurological diseases. Guanosine 5'-diphosphate disodium salt is promising for the research of inflammation, such as anemia of inflammation (AI) [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: GDP disodium salt. CAS No. 7415-69-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-113066A. | |
| Matriptase-2 from Human, Recombinant | Matriptase-2 (TMPRSS6) is a type II transmembrane serine protease mainly produced by the liver. It acts as a potent negative regulator of hepcidin, a hepatic peptide hormone and integral player in regulating iron homeostasis. Group: Enzymes. Synonyms: Transmembrane protease serine 6; TMPRSS6; Matriptase-2. Enzyme Commission Number: EC 3.4.21.-. Purity: Purified by multi-step chromatography. Matriptase-2. Mole weight: ~84 kDa; a-subunit: ~56kDa; b-subunit: ~28kDa. Activity: ~2.5U/ul. Stability: Stable for at least 6 months when stored at -20°C. Recommended Assay Buffer: 100mM TRIS, pH 9.0, containing 0.5mg/ml BSA. Do not store diluted solutions. Storage: Short Term Storage: -20°C; Long Term Storage: -80°C. Form: Liquid. In 100mM TRIS-HCl, pH 9.0, containing 150 mM sodium chloride and 20% glycerol. Source: Drosophila Schneider 2 (S2) cells. Species: Human. Transmembrane protease serine 6; TMPRSS6; Matriptase-2. Cat No: NATE-0857. |  |
| Roxadustat | Roxadustat is an orally active hypoxia-inducible factor (HIF) prolyl-hydroxylase (PHD) inhibitor (HIF-PHI) that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation, and reducing hepcidin [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FG-4592. CAS No. 808118-40-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-13426. | |
| Rusfertide | Rusfertide is a mimic of hepcidin. Synonyms: UNII-XM71MYX0IQ; XM71MYX0IQ; PTG-300; S6,S16-cyclo[N-(3-methylbutanoyl)-L-α-aspartyl-L-threonyl-L-histidyl-L-phenylalanyl-L-prolyl-L-cysteinyl-L-isoleucyl-N6-(N-hexadecanoyl-L-γ-glutamyl)-L-lysyl-L-phenylalanyl-L-α-glutamyl-L-prolyl-L-arginyl-L-seryl-L-lysylglycyl-L-cysteinyl-L-lysinamide]. CAS No. 1628323-80-7. Molecular formula: C114H181N27O28S. Mole weight: 2441.95. | |
| Rusfertide | Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin , reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: PTG-300. CAS No. 1628323-80-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P10272. | |
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