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| Product | Description | |
|---|---|---|
| HIV-1 integrase inhibitor | HIV-1 integrase inhibitor is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 544467-07-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13025. |  |
| HIV-1 integrase inhibitor | HIV-1 integrase inhibitor is uesful for anti-HIV, which can target HIV-1 integrase and depress the activity in the treatment of HIV infection, AIDS, and other similar diseases characterized by integration of a retroviral genome into a host chromosome. Synonyms: (Z)-4-(3-(azidomethyl)phenyl)-2-hydroxy-4-oxobut-2-enoic acid. Grades: >98%. CAS No. 544467-07-4. Molecular formula: C11H9N3O4. Mole weight: 247.21. |  |
| HIV-1 integrase inhibitor 2 | HIV-1 integrase inhibitor 2 is useful for anti-HIV, which can target HIV-1 integrase and depress the activity in the treatment of HIV infection, AIDS, and other similar diseases characterized by integration of a retroviral genome into a host chromosome. It did not affect integrase-DNA binding and only weakly inhibited the catalytic activities of integrase. Synonyms: CX04328; CX-04328; CX 04328; 3-Quinolineacetic acid, 6-chloro-2-methyl-4-phenyl-a-propyl-. Grades: >98%. CAS No. 957890-42-5. Molecular formula: C21H20ClNO2. Mole weight: 353.84. | |
| 10-Hydroxy Cabotegravir | 10-Hydroxy Cabotegravir is a metabolite of Cabotegravir (C050100). Cabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C19H17F2N3O6, Molecular Weight: 421.35. US Biological Life Sciences. |  Worldwide |
| 10-Hydroxy Cabotegravir-d3 | 10-Hydroxy Cabotegravir-d3 is the labelled form of 10-Hydroxy Cabotegravir. 10-Hydroxy Cabotegravir is a metabolite of Cabotegravir (C050100). Cabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C19H14D3F2N3O6, Molecular Weight: 424.37. US Biological Life Sciences. | Worldwide |
| 1-(2,2-Dimethoxyethyl)-1,4-dihydro-4-oxo-2,5-pyridinedicarboxylic Acid 2,5-Diethyl Ester | 1-(2,2-Dimethoxyethyl)-1,4-dihydro-4-oxo-2,5-pyridinedicarboxylic Acid 2,5-Diethyl Ester is an intermediate used in the synthesis of Defluoro Dolutegravir (D228715), which is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector. Group: Biochemicals. Grades: Highly Purified. CAS No. 1246616-75-0. Pack Sizes: 5mg, 10mg. Molecular Formula: C15H21NO7, Molecular Weight: 327.33. US Biological Life Sciences. | Worldwide |
| 1-(2,3-Dihydroxypropyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic Acid | 1-(2,3-Dihydroxypropyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic Acid is an intermediate in the synthesis of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 1206102-06-8. Pack Sizes: 10mg, 25mg. Molecular Formula: C16H17NO6. US Biological Life Sciences. | Worldwide |
| 1-(2,3-Dihydroxypropyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic Acid Methyl Ester | 1-(2,3-Dihydroxypropyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic Acid Methyl Ester is an intermediate in the synthesis of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 1206102-07-9. Pack Sizes: 10mg, 25mg. Molecular Formula: C17H19NO6, Molecular Weight: 333.34. US Biological Life Sciences. | Worldwide |
| 13-Hydroxy Cabotegravir | 13-Hydroxy Cabotegravir is a metabolite of Cabotegravir (C050100). Cabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C19H17F2N3O6, Molecular Weight: 421.35. US Biological Life Sciences. | Worldwide |
| 13-Hydroxy Cabotegravir-d3 | 13-Hydroxy Cabotegravir-d3 is the labelled form of 13-Hydroxy Cabotegravir. 13-Hydroxy Cabotegravir is a metabolite of Cabotegravir (C050100). Cabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C19H14D3F2N3O6, Molecular Weight: 424.37. US Biological Life Sciences. | Worldwide |
| 1-Benzyl-3-bromobenzene | 1-Benzyl-3-bromobenzene is used in the synthesis of inhibitors of HIV-1 integrase. It is also used to prepare C-arylglucoside inhibitors of renal sodium-dependent glucose transporter SGLT2. Group: Biochemicals. Grades: Highly Purified. CAS No. 27798-39-6. Pack Sizes: 250mg, 2.5g. Molecular Formula: C13H11Br. US Biological Life Sciences. | Worldwide |
| 1-Butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide | 1-Butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (compound 8) is an HIV-1 integrase inhibitor that effectively inhibits both the 3'-processing (3'-P) and strand transfer (ST) steps of the integration reaction. 1-Butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide can be utilized in HIV-1 research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMIM-TFSI; BMI-TFSI. CAS No. 174899-83-3. Pack Sizes: 1 mg. Product ID: HY-W010937. | |
| 2-[(1E)-2-Phenylethenyl]-3-(phenylmethoxy)-4H-pyran-4-one | 2-[(1E)-2-Phenylethenyl]-3-(phenylmethoxy)-4H-pyran-4-one is an intermediate in the synthesis of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 1206102-05-7. Pack Sizes: 25mg, 100mg. Molecular Formula: C20H16O3. US Biological Life Sciences. | Worldwide |
| 21-Hydroxy Cabotegravir | 21-Hydroxy Cabotegravir is a metabolite of Cabotegravir (C050100). Cabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C19H17F2N3O6, Molecular Weight: 421.35. US Biological Life Sciences. | Worldwide |
| 21-Hydroxy Cabotegravir-d3 | 21-Hydroxy Cabotegravir-d3 is the labelled form of 21-Hydroxy Cabotegravir. 21-Hydroxy Cabotegravir is a metabolite of Cabotegravir (C050100). Cabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C19H14D3F2N3O6, Molecular Weight: 424.37. US Biological Life Sciences. | Worldwide |
| 24-Hydroxy Cabotegravir | 24-Hydroxy Cabotegravir is a metabolite of Cabotegravir (C050100). Cabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 2.5mg. Molecular Formula: C19H17F2N3O6, Molecular Weight: 421.35. US Biological Life Sciences. | Worldwide |
| 24-Hydroxy Cabotegravir-d3 | 24-Hydroxy Cabotegravir-d3 is the labelled form of 24-Hydroxy Cabotegravir. 24-Hydroxy Cabotegravir is a metabolite of Cabotegravir (C050100). Cabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C19H14D3F2N3O6, Molecular Weight: 424.37. US Biological Life Sciences. | Worldwide |
| 26-Hydroxy Cabotegravir | 26-Hydroxy Cabotegravir is a metabolite of Cabotegravir (C050100). Cabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 5mg. Molecular Formula: C19H17F2N3O6, Molecular Weight: 421.35. US Biological Life Sciences. | Worldwide |
| 26-Hydroxy Cabotegravir-d3 | 26-Hydroxy Cabotegravir-d3 is the labelled form of 26-Hydroxy Cabotegravir. 26-Hydroxy Cabotegravir is a metabolite of Cabotegravir (C050100). Cabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C19H14D3F2N3O6, Molecular Weight: 424.37. US Biological Life Sciences. | Worldwide |
| 2-Bromophenanthridone | 2-Bromophenanthridone is a 2-bromo substituted derivative of phenathridinone that exhibits aryl hydrocarbon (Ah) receptor antagonist activity. It is also used in the preparation of potential HIV-1 integrase inhibitors. Group: Biochemicals. Alternative Names: 2-Bromo-6(5H)-phenanthridinone; NSC 112910; SG 00589. Grades: Highly Purified. CAS No. 27353-48-6. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 2-Methyltetrahydro-2-furancarbonitrile | 2-Methyltetrahydro-2-furancarbonitrile is used as a reagent for the synthesis of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 19679-75-5. Pack Sizes: 100mg, 500mg. Molecular Formula: C6H9NO, Molecular Weight: 111.14. US Biological Life Sciences. | Worldwide |
| 3'-Aminoacetophenone | 3'-Aminoacetophenone has potential anti-bacterial properties in addition to being used in the synthesis of selective antagonists at human A2B adenosine receptors. As well, it is used in the synthesis of HIV-1 Integrase Inhibitors. Group: Biochemicals. Alternative Names: 1-(3-Aminophenyl)ethan-1-one; 1-(3-Aminophenyl)ethanone; 1-Acetyl-3-aminobenzene; 3-Acetylaniline; 3-Acetylphenylamine; 3-Methylcarbonylaniline; 3'-Aminoacetophenone; NSC 7637; m-Acetylaniline; m-Aminoacetophenone; m-Aminoacetylbenzene; β-Aminoacetophenone. Grades: Highly Purified. CAS No. 99-03-6. Pack Sizes: 25g. US Biological Life Sciences. | Worldwide |
| 3-Benzyloxy-2-(2-hydroxy-2-phenylethyl)-4H-pyran-4-one | 3-Benzyloxy-2-(2-hydroxy-2-phenylethyl)-4H-pyran-4-one is an intermediate in the synthesis of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 1206102-04-6. Pack Sizes: 25mg, 50mg. Molecular Formula: C20H18O4. US Biological Life Sciences. | Worldwide |
| 3-Bromo-1-(2,2-dimethoxyethyl)-1,4-dihydro-4-oxo-2,5-pyridinedicarboxylic Acid 2,5-Diethyl Ester | 3-Bromo-1-(2,2-dimethoxyethyl)-1,4-dihydro-4-oxo-2,5-pyridinedicarboxylic Acid 2,5-Diethyl Ester is an intermediate in the synthesis of Defluoro Dolutegravir (D228715). Defluoro Dolutegravir is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector. Group: Biochemicals. Grades: Highly Purified. CAS No. 1246616-76-1. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C15H20BrNO7, Molecular Weight: 406.23. US Biological Life Sciences. | Worldwide |
| 3-Bromo-1,4-dihydro-4-oxo-1-(2-oxoethyl)-2,5-pyridinedicarboxylic Acid 2,5-Diethyl Ester | 3-Bromo-1,4-dihydro-4-oxo-1-(2-oxoethyl)-2,5-pyridinedicarboxylic Acid 2,5-Diethyl Ester is an intermediate in the synthesis of Defluoro Dolutegravir (D228715). Defluoro Dolutegravir is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector. Group: Biochemicals. Grades: Highly Purified. CAS No. 1246616-77-2. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C13H14BrNO6, Molecular Weight: 360.16. US Biological Life Sciences. | Worldwide |
| 4-Hydroxy Coumarin | 4-Hydroxy Coumarin is a plant derived antioxidant, protecting against lipid peroxidation, as well as a potential inhibitor of HIV-1 Integrase. Group: Biochemicals. Alternative Names: 4-Hydroxy-2H-1-benzopyran-2-one; 4-Coumarinol; 4-Hydroxy-2H-1-benzopyran-2-one; 4-Hydroxy-2H-benzo[b]pyran-2-one; 4-Hydroxy-2H-chromen-2-one; 4-Hydroxychromen-2-one; 4-Hydroxycoumariin; 4-Hydroxycoumarin; Benzotetronic Acid; NSC 11889. Grades: Highly Purified. CAS No. 1076-38-6. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 4-Oxo-1,4-dihydroquinoline Carboxylic Acid | 4-Oxo-1,4-dihydroquinoline Carboxylic Acid is a novel HIV-1 integrase strand transfer inhibitor. Group: Biochemicals. Alternative Names: 1,4-Dihydro-4-oxo-3-quinolinecarboxylic Acid; 4-Quinolone-3-carboxylic Acid. Grades: Highly Purified. CAS No. 13721-01-2. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 5,6-Dihydroxyindole-2-carboxylic Acid | 5,6-Dihydroxyindole-2-carboxylic Acid is the indole analogue of DOPA. 5,6-Dihydroxyindole-2-carboxylic Acid is a precursor to melanin as well as potential as HIV-1 integrase inhibitors. Group: Biochemicals. Alternative Names: 2-Carboxy-5,6-dihydroxyindole; 5,6-Dihydroxy-1H-indole-2-carboxylic Acid; 5,6-Dihydroxy-2-carboxyindole. Grades: Highly Purified. CAS No. 4790-8-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| BI 224436 | BI 224436 is a novel HIV-1 non-catalytic-site integrase inhibitor; has antiviral EC50s of <15 nM against different HIV-1 laboratory strains and cellular cytotoxicity of>90 μM. Synonyms: BI-224436; BI 224436; BI224436. Grades: >98%. CAS No. 1155419-89-8. Molecular formula: C27H26N2O4. Mole weight: 442.51. | |
| BI 224436 | BI 224436 is a novel HIV-1 noncatalytic site integrase inhibitor with EC 50 values of less than 15 nM against different HIV-1 laboratory strains. Uses: Scientific research. Group: Signaling pathways. CAS No. 1155419-89-8. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18595. | |
| Bictegravir | Bictegravir (GS-9883) is a potent inhibitor of HIV-1 integrase with an IC 50 of 7.5 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GS-9883. CAS No. 1611493-60-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17605. | |
| Bictegravir | Bictegravir is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM for strand transfer activity. Bictegravir is a drug of the integrase inhibitor class that was copied from Dolutegravir by scientists at Gilead Sciences. Bictegravir also inhibits HIV-1 viral infection in MT-2 and MT-4 cells, CD4+ T cells, and macrophages (EC50s = 1.5, 2.5, 1.5, and 6.6 nM, respectively) without exhibiting cytotoxicity (CC50s = 10.3, 3.7, 13, and 29.8 μM, respectively). In 2016, bictegravir was in a Phase 3 trial as part of a single tablet regimen in combination with tenofovir alafenamide (TAF) and emtricitabine (FTC) for the treatment of HIV-1 infection. Synonyms: GS-9883; GS 9883; GS9883. Grades: ≥98%. CAS No. 1611493-60-7. Molecular formula: C21H18F3N3O5. Mole weight: 449.39. | |
| Bictegravir sodium | Bictegravir sodium is a HIV-1 integrase strand transfer inhibitor that is derived from the drug dolutegravir. Synonyms: Bictegravir sodium|1807988-02-8|Bictegravir (sodium)|UNII-4L5MP1Y7W7|4L5MP1Y7W7|sodium;(1S, 11R, 13R)-3, 6-dioxo-7-[(2, 4, 6-trifluorophenyl)methylcarbamoyl]-12-oxa-2, 9-diazatetracyclo[11.2.1.02, 11.04, 9]hexadeca-4, 7-dien-5-olate|Bictegravir sodium [USAN]|Bictegravir sodium (JAN / USAN) |CHEMBL3989867|SCHEMBL 19991461|CHEBI: 172961|BCP20910|HY-17605A|AC-30681|CS-0380750|D10910|N16970|A904622|Q27259 952|GS-9883; GS 9883; GS9883; GS-9883-01; GS9883-01; GS 9883-01|(2R,5S,13aR)-8-Hydroxy-7,9-dioxo-N-((2,4,6-trifluorophenyl)methyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido(1',2':4,5)pyrazino(2,1-b)(1,3)oxazepine-10-carboxamide monosodium salt|2,5-Methanopyrido(1',2':4,5)pyrazino(2,1-b)(1,3)oxazepine-10-carboxamide, 2,3,4,5,7,9,13,13a-octahydro-8-hydroxy-7,9-dioxo-N-((2,4,6-trifluorophenyl)methyl)-, sodium salt (1:1), (2R,5S,13aR)-|Sodium (2R,5S,13aR)-7,9-dioxo-10-((2,4,6-trifluorobenzyl)carbamoyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1, 3]oxazepin-8-olate|sodium (2R,5S,13aR)-7,9-dioxo-10-[(2,4,6-trifluorobenzyl)carbamoyl]-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepin-8-olate. Grades: >98%. CAS No. 1807988-02-8. Molecular formula: C21H17F3N3NaO5. Mole weight: 471.4. | |
| Bictegravir sodium | Bictegravir sodium is a potent inhibitor of HIV-1 integrase , with an IC 50 of 7.5 nM. Bictegravir sodium exhibits potent and selective anti-HIV activity and low cytotoxicity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GS-9883 sodium. CAS No. 1807988-02-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17605A. | |
| Cabotegravir (GSK744, GSK1265744) | Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor against a broad range of HIV subtypes, and inhibits the HIV-1 integrase catalyzed strand transfer reaction with IC50 of 3.0 nM. Phase 2. Uses: Hiv integrase inhibitors. Synonyms: S/GSK1265744; S/GSK 1265744; S/GSK-1265744; GSK744; GSK-744; GSK 744; Cabotegravir. Grades: >98%. CAS No. 1051375-10-0. Molecular formula: C19H17F2N3O5. Mole weight: 405.35. | |
| D,L-Serine, Methyl Ester, Hydrochloride | D,L-Serine Methyl Ester Hydrochloride is used as a reactant in the preparation of chicoric acid analogs as HIV-1 integrase inhibitors. Also used in the total synthesis of (-)-Hennoxazole A. Group: Biochemicals. Grades: Highly Purified. CAS No. 5619-4-5. Pack Sizes: 10g, 25g, 50g, 100g. Molecular Formula: C?H?NO? HCl. US Biological Life Sciences. | Worldwide |
| Dolutegravir | Dolutegravir is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector. Group: Biochemicals. Alternative Names: (4R, 12aS)-N-[(2, 4-Difluorophenyl)methyl]-3, 4, 6, 8, 12, 12a-hexahydro-7-hydroxy-4-methyl-6, 8-dioxo-2H-pyrido[1', 2':4, 5]pyrazino[2, 1-b][1, 3]oxazine-9-carboxamide; GSK 1349572; S/GSK1349572. Grades: Highly Purified. CAS No. 1051375-16-6. Pack Sizes: 5mg, 10mg, 25mg. Molecular Formula: C20H19F2N3O5, Molecular Weight: 419.38. US Biological Life Sciences. | Worldwide |
| Dolutegravir | Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC 50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC 50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC 50 =3.6-5.8 nM) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: S/GSK1349572. CAS No. 1051375-16-6. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-13238. | |
| Dolutegravir (GSK1349572) | Dolutegravir is a two-metal-binding HIV-1 integrase inhibitor with IC50 of 2.7 nM, with modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. It blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). Synonyms: GSK-1349572; GSK 1349572; GSK1349572; Tivicay. Grades: ≥98%. CAS No. 1051375-16-6. Molecular formula: C20H19F2N3O5. Mole weight: 419.38. | |
| Dolutegravir sodium | Dolutegravir sodium (S/GSK1349572 sodium) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC 50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir sodium (S/GSK1349572 sodium) inhibits HIV-1 viral replication with an IC 50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir sodium (S/GSK1349572 sodium) retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC 50 =3.6-5.8 nM) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: S/GSK1349572 sodium. CAS No. 1051375-19-9. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13238A. | |
| Elvitegravir | Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1 IIIB , HIV-2 EHO and HIV-2 ROD with IC 50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GS-9137; JTK-303; D06677. CAS No. 697761-98-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14740. | |
| Elvitegravir | Elvitegravir is an HIV-1 integrase strand transfer inhibitor (INSTI) for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively. Uses: Anti-retroviral agents. Synonyms: GS-9137; GS 9137; GS9137; JTK-303; JTK 303; JTK303; EVG; D06677; D 06677; D-06677. Grades: ≥98%. CAS No. 697761-98-1. Molecular formula: C23H23ClFNO5. Mole weight: 447.88. | |
| Equisetin | The tetramic acid equisetin, is produced by a number of species of Fusarium. Interest in equisetin emerged with reports of its inhibitory activity against human immunodeficiency virus type 1 (HIV-1) integrase in vitro that was mechanistically distinct from previously described inhibitors. Equisetin inhibits 3' end-processing and strand transfer as well as disintegration catalysed by either the full-length enzyme or the truncated integrase core. Group: Biochemicals. Grades: Highly Purified. CAS No. 57749-43-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Funalenone | Funalenone is a phenalene compound originally isolated from A. niger. It inhibits HIV-1 integrase and type I collagenase. Funalenone is also a selective inhibitor of matrix metalloproteinase-1 (MMP-1; IC50 = 170 μM). Synonyms: 8-deoxyxanthoherquein; 3,4,7,9-tetrahydroxy-2-methoxy-6-methyl-1H-phenalen-1-one. Grades: ≥95%. CAS No. 259728-61-5. Molecular formula: C15H12O6. Mole weight: 288.25. | |
| Funalenone (3,4,7,9-Tetrahydroxy-6-methyl-1H-phenalen-1-one) | Matrix metalloproteinase-1 (MMP-1; Type I collagenase) inhibitor. HIV-1 integrase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 259728-61-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| His-Cys-Lys-Phe-Trp-Trp | His-Cys-Lys-Phe-Trp-Trp inhibits HIV-1 integrase (IN)-mediated 3'-processing and integration of HIV DNA. Synonyms: H-His-Cys-Lys-Phe-Trp-Trp-OH; HIV Integrase Protein Inhibitor(1); L-Tryptophan,l-histidyl-L-cysteinyl-L-Lysyl-L-phenylalanyl-l-tryptophyl-. CAS No. 172546-75-7. Molecular formula: C46H55N11O7S. Mole weight: 906.06. | |
| HIV-1 inhibitor-6 | HIV-1 inhibitor-6 (compound 9), a diheteroarylamide-based compound, is a potent HIV-1 pre-mRNA alternative splicing inhibitor. HIV-1 inhibitor-6 blocks HIV replication. HIV-1 inhibitor-6 is active against wild-type HIV-1IIIB (subtype B, X4-tropic) and HIV-1 97USSN54 (subtype A, R5-tropic) with EC 50 s of 0.6 μM and 0.9 μM, respectively. HIV-1 inhibitor-6 inhibits HIV strains resistant to agents targeting HIV reverse transcriptase, protease, integrase, and coreceptor CCR5 with EC 50 s ranging from 0.9 to 1.5 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1821309-39-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134851. | |
| Integracin B | Integracin B is an unusual ester of two structurally related alkylresourcinols first isolated from a fungus, Cytonaema sp. in 2002 as a potent inhibitor of HIV-1 integrase. With the exception of this intial report, Integracin B has received little or no further attention. Group: Biochemicals. Grades: Highly Purified. CAS No. 224186-05-4. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Lavendustin B | Lavendustin B is a competitive inhibitor of glucose transporter 1 (Glut1), and also an inhibitor of the interaction between HIV-1 integrase and LEDGF/p75. It can be used as a negative control of Lavendustin A. Synonyms: 5-[bis[(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid. Grades: ≥95%. CAS No. 125697-91-8. Molecular formula: C21H19NO5. Mole weight: 365.38. | |
| L-Chicoric Acid | L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC 50 of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: (-)-Chicoric acid; trans-Caffeoyltartaric acid. CAS No. 70831-56-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-N0457A. | |
| L-Chicoric Acid | L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC50 of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 70831-56-0. Molecular formula: C22H18O12. Mole weight: 474.37. Purity: 0.9998. Product ID: ACM70831560. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Raltegravir Potassium Salt | Raltegravir is a potent, selective, and orally bioavailable inhibitor of HIV integrase (IC50 = 15 nM). It is metabolized primarily by uridine diphosphate glucuronosyltransferase 1A. Raltegravir has long-term efficacy and safety in managing HIV-1 infection in adults, children, and adolescents. Uses: Anti-hiv agents. Synonyms: MK-0518; MK 0518; MK0518; Raltegravir. Grades: 98%. CAS No. 871038-72-1. Molecular formula: C20H20FKN6O5. Mole weight: 482.514. | |
| Rugulosin | Antibiotic. Antibacteriophage. Antiviral. Mycotoxin. DNA replication, transcription and repair inhibitor. Antibacterial. RNA polymerase and ribonuclease H inhibitor. Insecticidal. Cytotoxic. HIV-1 integrase inhibitor. Shows anti-MRSA (methicillin-resistant Staphylococcus aureus) activity. Source:Isolated from Penicillium sp. Group: Biochemicals. Alternative Names: (+)-Rugulosin, NSC 160880, NSC 249990, Radicalisin. Grades: Highly Purified. CAS No. 23537-16-8. Pack Sizes: 250ug, 1mg. Molecular Formula: C30H22O10, Molecular Weight: 542.5. US Biological Life Sciences. | Worldwide |
| Triethyl methanetricarboxylate | Triethyl methanetricarboxylate (CAS# 6279-86-3) is used in the synthesis of novel inhibitors of Hsp90. It is also used in the preparation of novel dihydroquinoline-3-carboxylic acids that function as HIV-1 integrase inhibitors. Synonyms: triethyl methanetricarboxylate. Grades: 95 %. CAS No. 6279-86-3. Molecular formula: C10H16O6. Mole weight: 232.23. | |
| Triethyl Methanetricarboxylate | Triethyl Methanetricarboxylate is used in the synthesis of novel inhibitors of Hsp90. It is also used in the preparation of novel dihydroquinoline-3-carboxylic acids that function as HIV-1 integrase inhibitors. Group: Biochemicals. Alternative Names: Diethyl (Carboethoxy)malonate; Diethyl (Ethoxycarbonyl) malonate; Diethyl 2-Ethoxycarbonyl malonate; NSC 11006; Tri (ethoxycarbonyl) methane; Tricarbethoxymethane; Tricarboethoxymethane; Triethyl Methanetricarboxylate; Tris (ethoxycarbonyl) methane. Grades: Highly Purified. CAS No. 6279-86-3. Pack Sizes: 25g. US Biological Life Sciences. | Worldwide |
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