Homologous Enzyme Suppliers USA
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Product | Description | |
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1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanol Sodium Salt Quick inquiry Where to buy Suppliers range | Phosphatidylethanol (PEth) represents a group of glycerophospholipid homologues generated by substitution of ethanol for the lipid headgroup by the phospholipase D enzyme. Since the formation of PEth is specifically dependent on ethanol, the diagnostic specificity of PEth as an alcohol biomarker is theoretically 100%. Group: Biochemicals. Grades: Highly Purified. CAS No. 322647-55-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C39H74NaO8P, Molecular Weight: 724.96. US Biological Life Sciences. | Worldwide |
6-Nitroveratraldehyde Quick inquiry Where to buy Suppliers range | DMNB is a derivative of vanillin with 100-fold potency compared to vanillin, and acts as an inhibitor of DNA-dependent protein kinase (DNA-PK) (IC50 = 15 μM). DNA-PK is an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells. Uses: Dmnb is a vanillin compound, which is a type of dna-pk inhibitor. Synonyms: 4,5-dimethoxy-2-nitrobenzaldehyde. Grades: ≥ 98 % by HPLC. CAS No. 20357-25-9. Molecular formula: C9H9NO5. Mole weight: 211.17. | |
Angiotensin Fragment 1-7 acetate Quick inquiry Where to buy Suppliers range | Angiotensin Fragment 1-7 is a major active component of the renin-angiotensin system (RAS), produced from cleavage of Ang II by angiotensin-converting-enzyme type 2 (ACE2). Angiotensin 1-7 inhibits purified canine ACE activity with IC50 of 0.65 μM. This peptide can be generated by the action of ACE2, a homolog of ACE, on angiotensin II or by the action of neprilysin on angiotensin I. It has been studied in the context of ameliorating the symptoms of metabolic syndrome. Synonyms: 5-L-isoleucine-1-7-angiotensin II; Ang-(1-7). Grades: ≥95%. Molecular formula: C41H62N12O11·xC2H4O2. Mole weight: 899. | |
CGM097 Quick inquiry Where to buy Suppliers range | CGM097 is an orally bioavailable HDM2 (human homolog of double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, p53/HDM2 interaction inhibitor CGM097 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of p53 signaling and, thus, the p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger nuclear phosphoprotein, is a negative regulator of the p53 pathway, often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival. Synonyms: CGM097; CGM-097; CGM 097; NVPCGM097; NVPCGM 097; NVPCGM-097; NVP CGM097; NVP CGM 097; NVP CGM-097. CAS No. 1313363-54-0. Molecular formula: C38H47ClN4O4. Mole weight: 659.27. | |
ML216 Quick inquiry Where to buy Suppliers range | Bloom (BLM) helicase is a DNA unwinding enzyme important for DNA repair in the homologous recombination pathway. Mutations of the BLM gene result in reduced BLM helicase activity that is associated with the rare genetic disorder, Bloom's Syndrome, and a predisposition to developing cancer. ML-216 is the first identified small molecule inhibitor of BLM helicase (IC50 = 1.8 μM) that is 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s ≥ 50 μM). At 25-50 μM, ML-216 has been shown to dose-dependently inhibit the proliferation of BLM-expressing PSNF5 fibroblast cells but not BLM-deficient PSNG13 fibroblast cells. Synonyms: ML 216; ML-216; CID-49852229; CID49852229; CID 49852229. Grades: >98%. CAS No. 1430213-30-1. Molecular formula: C15H9F4N5OS. Mole weight: 383.32. | |
PDD 00017273 Quick inquiry Where to buy Suppliers range | PDD 00017273 is a potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor (IC50 = 26 nM), with >350-fold selectivity for PARG over a panel of ion channels, enzymes and receptors, including PARP1 and ARH3. PARG has been shown to be involved in the repair of single strand DNA breaks. PDD 00017273 (0.3 μM) also reduces the viability of BRCA1, BRCA2, PALB2, FAM175A, and BARD1 depleted cells. PDD 00017273 stalls replication forks and induces DNA damage that requires homologous recombination (HR) for repair. Synonyms: 1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide. Grades: ≥98% by HPLC. CAS No. 1945950-21-9. Molecular formula: C23H26N6O4S2. Mole weight: 514.62. |