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| Product | Description | |
|---|---|---|
| Hsp90a Active human | recombinant, expressed in E. coli, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. |  |
| Hsp90b Active human | recombinant, expressed in E. coli, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Hsp90-Cdc37-IN-1 | Hsp90-Cdc37-IN-1, an Hsp90-Cdc37 interaction disruptor, can inhibit cell migration and reverse drug resistance, with an IC50 of 140 nM. Synonyms: Olean-12-en-29-oic acid, 3-[4-[(6-fluoro-2-benzothiazolyl)amino]-1,4-dioxobutoxy]-11-oxo-, ethyl ester, (3β,20β)-; Ethyl (3β)-3-({4-[(6-fluoro-1,3-benzothiazol-2-yl)amino]-4-oxobutanoyl}oxy)-11-oxoolean-12-en-30-oate. Grade: ≥95%. CAS No. 2227303-22-0. Molecular formula: C43H57FN2O6S. Mole weight: 748.99. |  |
| HSP90?, His tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Hsp90-IN-17 hydrochloride | Hsp90-IN-17 (Example 5) hydrochloride is an HSP90 inhibitor that can be used in the study of proliferative diseases, such as cancer and neurodegenerative diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1253584-63-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148215A. |  |
| HSP90-IN-22 | HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor with antiproliferative properties on cells with IC 50 values of 3.65 μM for MCF7 breast cancer cells and 2.71 μM for SKBr3 breast cancer cells, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 442898-75-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-153588. | |
| Anti-HSP90AA1 antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-HSP90AB1 antibody produced in rabbit | IgG fraction of antiserum. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-phospho-HSP90AB1 (pSer254) antibody produced in rabbit | affinity isolated antibody. Group: Fluorescence/luminescence spectroscopy. | |
| Benzisoxazole Hsp90 Inhibitor | Benzisoxazole Hsp90 inhibitor inhibits the proliferation of several cancer cell lines with IC50 of 0.28 μM, which promotes the degradation of the Hsp90 client proteins Her-2 and androgen receptor, and has no effect on a variety of kinases. Synonyms: BHI. Grade: ≥98%. CAS No. 1012788-65-6. Molecular formula: C19H20ClN3O4. Mole weight: 389.8. | |
| 1- (2, 4-Dihydroxy-5-isopropylphenyl) ethanone | 1- (2, 4-Dihydroxy-5-isopropylphenyl) ethanone acts as a reagent in the synthesis of 3,5-disubstituted-4-alkynylisoxozales as HSP90 inhibitors against various human cancer cell lines. Group: Biochemicals. Grades: Highly Purified. CAS No. 747414-17-1. Pack Sizes: 250mg, 500mg. Molecular Formula: C11H14O3, Molecular Weight: 194.23. US Biological Life Sciences. |  Worldwide |
| 1-[4-Bromo-2-(bromomethyl)phenyl]-3,3-difluoro-pyrrolidine | 1-[4-Bromo-2-(bromomethyl)phenyl]-3,3-difluoro-pyrrolidine is derived from 5-Bromo-2-nitrotoluene (B698095), which is used in the synthesis of biphenylamide derivatives as Hsp90 C-terminal inhibitor for the treatment of cancer and neurodegenerative diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 2024458-38-4. Pack Sizes: 25mg, 100mg. Molecular Formula: C11H11Br2F2N, Molecular Weight: 355.02. US Biological Life Sciences. | Worldwide |
| 1,4-Cyclohexanediol (Cis/Trans Mixture) | 1,4-Cyclohexanediol is used as a reagent in the development of noviomimetics as C-terminal Hsp90 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 556-48-9. Pack Sizes: 5g, 25g. Molecular Formula: C6H12O2, Molecular Weight: 116.16. US Biological Life Sciences. | Worldwide |
| 17-AAG | 17-AAG is an antibiotic with antineoplastic activity that inhibits heat shock protein 90 (HSP90). It was shown to induce apoptosis of mouse lymphoma cancer stem cells (CSCs) and human acute myeloid leukemia (AML) CSCs. Synonyms: Tanespimycin; 17-Allylaminogeldanamycin; BAY 579352; 17-(Allylamino) Geldanamycin; 17-Demethoxy-17-(2-propenylamino)geldanamycin; 17-(Allylamino)-17-demethoxygeldanamycin; 17-Demethoxy-17-allylaminogeldanamycin; CP 127374; NSC 330507; Tanespimycin; 17AAG. Grade: >98%. CAS No. 75747-14-7. Molecular formula: C31H43N3O8. Mole weight: 585.69. | |
| 17-AAG | Potent, less toxic analog of geldanamycin. Inhibits the essential ATPase activity of HSP90. Telomerase activity inhibitor. Apoptosis inducer and antitumor compound. Group: Biochemicals. Grades: Highly Purified. CAS No. 75747-14-7. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| 17-AAG (17-allylamino-17-demethoxygeldanamycin, Telatinib, Tanespimycin, NSC-330507, CNF-101, KOS-953, GLD-36, CP 127374) | Semi-synthetic derivative of geldanamycin, demonstrating greater stability and lower in vivo toxicity than its parent compound. 17-AAG binds specifically to heat shock protein Hsp90 in a manner similar to geldanamycin, but the binding is weaker. Group: Biochemicals. Grades: Highly Purified. CAS No. 75747-14-7. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| 17-AAG hydrochloride | 17-AAG hydrochloride is a potent HSP90 inhibitor with IC50 value of 5 nM, which is a 100-fold higher binding affinity for HSP90 derived from tumour cells than that from normal cells. It is less toxic by binding to Hsp90 and altering its function. It causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells. It has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively. It displays significantly higher binding affinity for Hsp90 from 3T3-src, B16 or CT26 xenografts in nude mice compared with that from the normal tissues in vivo. Uses: 17-aag hydrochloride has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant t315i and e255k bcr-abl mutants. Synonyms: 17-AAG hydrochloride; 17 AAG hydrochloride; 17AAG hydrochloride; [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate hydrochloride; Tanespimycin Hydrochloride; NSC 330507 Hydrochloride; CP 127374 Hydrochloride; 17-(Allylamino)-17-desmethylgeldanamycin hydrochloride. Grade: >98%. CAS No. 911710-03-7. Molecular formula: C31H44ClN3O8. Mole weight: 622.15. | |
| 17-AEP-GA | 17-AEP-GA, an ADC toxin and HSP90 antagonist, is a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion. Synonyms: Geldanamycin, 17-demethoxy-17-[[2-(1-pyrrolidinyl)ethyl]amino]-; 17-(2-(pyrrolidin-1-yl)ethyl)amino-17-demethoxygeldanamycin; 2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-[(aminocarbonyl)oxy]-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-19-[[2-(1-pyrrolidinyl)ethyl]amino]-, (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-. Grade: >98.0%. CAS No. 75747-23-8. Molecular formula: C34H50N4O8. Mole weight: 642.78. | |
| 17-AG | An orally bioavailable formulation of the ansamycin derivative 17-amino-17-demethoxygeldanamycin (17-AG) with potential antineoplastic activity. Oral Hsp90 inhibitor IPI-493 binds to and inhibits Hsp90, which may result the in growth inhibition in sensitive tumor cell populations. Synonyms: 17 AG; 17AG; 17-AG; IPI493; IPI 493; IPI-493; NSC 255109; NSC255109; NSC-255109; 17-Aminogeldanamycin; 17-Amino Geldanamycin; 17-Aminodemethoxygeldanamycin; 17-Amino-17-demethoxygeldanamycin. Grade: >98%. CAS No. 64202-81-9. Molecular formula: C28H39N3O8. Mole weight: 545.62. | |
| 17-(Allylamino-d5) Geldanamycin | Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. Group: Biochemicals. Alternative Names: 17-Demethoxy-17-(2-propenylamino-d5)geldanamycin; 17-(Allylamino-d5)-17-demethoxygeldanamycin; 17-(Allylamino-d5)-17-desmethylgeldanamycin; 17-Demethoxy-17-(allylamino-d5)geldanamycin; 17AAG-d5; CP 127374-d5; KOS 953-d5; NSC 330507-d5; Tanespimycin-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 17-(Allylamino) Geldanamycin | Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. Group: Biochemicals. Alternative Names: 17-Demethoxy-17- (2-propenylamino) geldanamycin; 17-(Allylamino)-17-demethoxygeldanamycin; 17-(Allylamino)-17-desmethylgeldanamycin; 17-Demethoxy-17-allyl aminogeldanamycin; 17AAG; CP 127374; KOS 953; NSC 330507; Tanespimycin; 17-AAG. Grades: Highly Purified. CAS No. 75747-14-7. Pack Sizes: 1mg, 10mg, 25mg, 100mg. Molecular Formula: C31H43N3O8, Molecular Weight: 585.69. US Biological Life Sciences. | Worldwide |
| 17-DMAG | 17-DMAG is a synthetic Geldanamycin derivative and inhibitor of Hsp90. Group: Biochemicals. Grades: Highly Purified. CAS No. 467214-20-6. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C32H48N4O8, Molecular Weight: 616.75. US Biological Life Sciences. | Worldwide |
| 17-DMAG hydrochloride | 17-DMAG hydrochloride (Alvespimycin hydrochloride) is the hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to Hsp90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. Synonyms: 17-DMAG HCl; Alvespimycin HCl; 17-Dimethylaminoethylamino-17-demethoxygeldanamycin Hydrochloride; 17-N-(2-Dimethylaminoethylamino)-17-demethoxy Geldanamycin Hydrochloride; 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin Hydrochloride; 17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin Hydrochloride; Alvespimycin Hydrochloride; DMAG Hydrochloride; NSC 707545 Hydrochloride; 17-DMAG Hydrochloride. Grade: >98%. CAS No. 467214-21-7. Molecular formula: C32H48N4O8.HCl. Mole weight: 653.21. | |
| 17-DMAG (NSC 707545, 17- [2-(Di methyl amino) et hyl ] amino-17-desmethoxygeldanamycin ) | Less toxic, more potent synthetic derivative of geldanamycin. Angiogenesis inhibitor. Heat shock protein 90 (HSP90) inhibitor. Apoptosis inducer. Shows higher antitumor activity than 17-AAG. Group: Biochemicals. Grades: Highly Purified. CAS No. 467214-20-6. Pack Sizes: 100ug, 1mg. US Biological Life Sciences. | Worldwide |
| 17-GMB-APA-GA | 17-GMB-APA-GA, an ADC cytotoxin, is a potent HSP90 inhibitor used to study latent T. gondii infection. Synonyms: Geldanamycin, 17-demethoxy-17-[[3-[[4-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxobutyl]amino]propyl]amino]-; (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-[(3-{[4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoyl]amino}propyl)amino]-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate. Grade: >99.3%. CAS No. 256337-10-7. Molecular formula: C39H53N5O11. Mole weight: 767.87. | |
| 17-N- (2-Di methyl aminoethylamino) -17-demethoxy Geldanamycin Hydrochloride | 17-DMAG is an analogue of Gelamycin and 17- (Allylamino) geldanamycin. 17-DMAG acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG. Group: Biochemicals. Alternative Names: 17-Demethoxy-17- [ [2- (dimethylamino) ethyl] amino] geldanamycin Hydrochloride; 17-N- (2-Di methyl aminoethylamino) -17-demethoxygeldanamycin Hydrochloride; 17-[2- (Dimethylamino) ethylamino]-17-desmethylgeldanamycin Hydrochloride; Alvespimycin Hydrochloride; DMAG Hydrochloride; NSC 707545 Hydrochloride; 17-DMAG Hydrochloride. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| 2,2,6-Trimethyl-4H-1,3-dioxin-4-one | 2,2,6-Trimethyl-4H-1,3-dioxin-4-one is used in the synthesis of dihydropyrimininones as picomolar sodium iodide symporter inhibitors. Also used in the synthesis of resorcinol amide Hsp90 Inhibitor AT13387. Group: Biochemicals. Alternative Names: Diketene Acetone Adduct. Grades: Highly Purified. CAS No. 5394-63-8. Pack Sizes: 10g, 100g. Molecular Formula: C7H10O3, Molecular Weight: 142.15. US Biological Life Sciences. | Worldwide |
| 2,4-Dichloro-5-nitrophenol | 2,4-Dichloro-5-nitrophenol is an intermediate used to prepare (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors. It is also used to synthesize cyanopyrrolo[2,3-d]pyrimidine derivatives as Hsp90 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 39489-77-5. Pack Sizes: 1g, 5 g. Molecular Formula: C6H3Cl2NO3. US Biological Life Sciences. | Worldwide |
| (2-Chloro-4-cyanophenyl)boronic Acid | (2-Chloro-4-cyanophenyl)boronic Acid is an intermediate used to prepare fused imidazole derivatives as TTK kinase inhibitors. It is also used in the synthesis of pyrimidothiophenes as HSP90 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 677743-50-9. Pack Sizes: 100mg, 500mg. Molecular Formula: C7H5BClNO2, Molecular Weight: 181.38. US Biological Life Sciences. | Worldwide |
| 2-(N,N-BisBOC-Amino)pyrimidine-5-boronic Acid, Pinacol Ester | 2-(N,N-BisBOC-Amino)pyrimidine-5-boronic Acid, Pinacol Ester acts as a reagent in the synthesis of pyrrolotriazine derivatives as PI3 kinase inhibitor, preparation of heteroaryl carbazoles as inhibitors of Hsp82 and Hsp90 proteins for treating cancer. Group: Biochemicals. Grades: Highly Purified. CAS No. 1190423-36-9. Pack Sizes: 100mg, 250mg. Molecular Formula: C20H32BN3O6, Molecular Weight: 421.3. US Biological Life Sciences. | Worldwide |
| 2-tert-Butyl-4-(2,4-dichloro-5-hydroxyphenyl]-Δ2-1,3,4-oxadiazolin-5-one | 2-tert-Butyl-4-(2,4-dic hloro-5-hydroxyphenyl]-Δ2-1,3,4-oxadiazolin-5-one is derived from 2,4-Dichloro-5-nitrophenol (D432070), which is an intermediate used to prepare (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors. It is also used to synthesize cyanopyrrolo[2,3-d]pyrimidine derivatives as Hsp90 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 39807-19-7. Pack Sizes: 10mg, 50mg. Molecular Formula: C12H12Cl2N2O3, Molecular Weight: 303.14. US Biological Life Sciences. | Worldwide |
| 3-? (4-?Morpholinyl) ?propanoic Acid Hydrochloride | 3-? (4-?Morpholinyl) ?propanoic Acid Hydrochloride is a reagent used in the synthesis of an ester prodrug of MPC-3100 (M326505), a recently discovered fully synthetic purine-based Hsp90 Inhibitor exhibiting anticancer properties. Group: Biochemicals. Grades: Highly Purified. CAS No. 6319-95-5. Pack Sizes: 500mg, 1g. Molecular Formula: C7H13NO3; HCl, Molecular Weight: 159.183646. US Biological Life Sciences. | Worldwide |
| 3-Aminobenzoic-d4 Acid | A chemoattractants against Pseudomonas strains. A reactant used in the preparation of influenza neuraminidase inhibitors, inhibitors of transthyretin amyloid fibril formation and Iihibitors of the protein chaperone Hsp90. Group: Biochemicals. Alternative Names: 3-Aminobenzenecarboxylic Acid; 3-Carboxyaniline; Aniline-3-carboxylic Acid; NSC 15012; m-Aminobenzoic Acid; m-Anthranilic Acid; m-Carboxyaniline; m-Carboxyphenylamine. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 3-Methyltoxoflavin | 3-Methyltoxoflavin is a novel Hsp90 inhibitor, which decreases the Hsp90-dependent client protein HER2 and induces cell death. Synonyms: 3-Methyltoxoflavin; 3 Methyltoxoflavin; 3Methyltoxoflavin; GNF-Pf-2272; 1,3,6-Trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione. CAS No. 32502-62-8. Molecular formula: C8H9N5O2. Mole weight: 207.193. | |
| 3-Phenyltoxoflavin | 3-Phenyltoxoflavin, a derivative of Toxoflavin, is an inhibitor of Hsp90 and has anti-cancer activity, with a Kd of 585 nM for the interaction of Hsp90-TPR2A. Synonyms: Pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione, 1,6-dimethyl-3-phenyl-; 1,6-Dimethyl-3-phenylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione; 1,6-Dimethyl-3-phenyl-1H,5H,6H,7H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione. Grade: ≥95%. CAS No. 32502-63-9. Molecular formula: C13H11N5O2. Mole weight: 269.26. | |
| 6-chloro-9-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-9H-purin-2-amine | BIIB021 is An orally active, purine-scaffold, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. BIIB021 that is currently undergoing Phase II testing, may have broader application against tumors with acquired multidrug resistance or tumors located in organs protected by MDR proteins, such as the adrenal glands, brain and testis. Uses: Biib 021 an orally available, fully synthetic small-molecule inhibitor of the heat shock protein hsp90. studies show that biib 021 adminisitration led to degradation of hsp90 client proteins measured in tumor tissue and resulted in the inhibition of tumor. Synonyms: [6-Chloro-9-(4-methoxy-3,5-dimethylpyridin-2-ylmethyl)-9H-purin-2-yl]amine; CNF-2024; CNF 2024; CNF2024. Grade: >98%. CAS No. 848695-25-0. Molecular formula: C14H15ClN6O. Mole weight: 318.76. | |
| 7-Aminocephalosporanic acid | 7-aminocephalosporanic acid (7-ACA) is a HSP90β inhibitor and an antibiotic. 7-Aminocephalosporanic acid is the core chemical structure of the synthesis of cephalosporin antibiotics and an effective β-lactamase inhibitor [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: 7-ACA. CAS No. 957-68-6. Pack Sizes: 100 mg. Product ID: HY-B1434. | |
| AICAR | Cell permeable AMP-activated protein kinase (AMPK) activator. Insulin mimetic. Adipocyte differentiation inhibitor. Apoptosis inducer. PPARalpha inhibitor. mTOR inhibitor. P70S6K inhibitor. LPS-induced TNFalpha production inhibitor. TORC2 phosphorylation inducer. Anti-inflammatory. Anti-tumor compound. Autophagy inhibitor. HSP90 inhibitor. Group: Biochemicals. Alternative Names: 5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside. Grades: Highly Purified. CAS No. 2627-69-2. Pack Sizes: 10mg, 50mg, 100mg. Molecular Formula: C9H14N4O5. US Biological Life Sciences. | Worldwide |
| Alvespimycin | Alvespimycin (17-DMAG) is a potent inhibitor of Hsp90 , binding to Hsp90 with an EC 50 of 62 ± 29 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 17-DMAG; KOS-1022; NSC 707545. CAS No. 467214-20-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10389. | |
| Alvespimycin | Alvespimycin (17-DMAG; KOS-1022; NSC 707545) is a potent, water-soluble Hsp90 inhibitor with IC50 of 62 nM. 17-DMAG displays ~2 times potency against human Hsp90 than 17-AAG, with IC50 of 62 nM versus 119 nM. In SKBR3 and SKOV3 cells which overexpress Hsp90 client protein Her2, 17-DMAG causes down-regulation of Her2 with EC50 of 8 nM and 46 nM, respectively, as well as induction of Hsp70 with EC50 of 4 nM and 14 nM, respectively, leading to significant cytotoxicity with GI50 of 29 nM and 32 nM, respectively, consistent with Hsp90 inhibition. In combination with vorinostat, 17-DMAG synergistically induces apoptosis of the cultured MCL cells as well as primary MCL cells, more potently than either agent alone, by markedly attenuating the levels of cyclin D1 and CDK4, as well as of c-Myc, c-RAF and Akt. 17-DMAG treatment at 5 mg/kg or 25 mg/kg three times per week significantly reduces tumor growth of TMK-1 xenografts, by reducing vessel area and numbers of proliferating tumor cells in sections. Consistent the inhibition of FAK signaling in vivo, 17-DMAG treatment at 25 mg/kg three times a week significantly suppresses tumor growth, and metastasis of ME180 and SiHa xenografts in mice. Administration of 17-DMAG at 10 mg/kg for 16 days significantly decreases the white blood cell count and prolongs the survival in a TCL1-SCID transplant mouse model. Uses: Hsp-90 inhibitor; potential anti-cancer drug. Synonyms: 17-DMAG; KOS 1022; K | |
| Alvespimycin hydrochloride | Alvespimycin hydrochloride (17-DMAG hydrochloride; KOS-1022; BMS 826476) is a potent inhibitor of Hsp90 , binding to Hsp90 with EC 50 of 62±29 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 17-DMAG hydrochloride; KOS-1022 hydrochloride; BMS 826476. CAS No. 467214-21-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 100 mg; 200 mg. Product ID: HY-12024. | |
| Aminohexylgeldanamycin | Aminohexylgeldanamycin, a derivative of Geldanamycin, is a potent HSP90 inhibitor with antiangiogenic and antitumor activities. Synonyms: AHGDM; Geldanamycin, 17-[(6-aminohexyl)amino]-17-demethoxy-; 2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-[(aminocarbonyl)oxy]-19-[(6-aminohexyl)amino]-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-, (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-. Grade: ≥95%. CAS No. 485395-71-9. Molecular formula: C34H52N4O8. Mole weight: 644.80. | |
| Aminohexylgeldanamycin | Aminohexylgeldanamycin (AHGDM), a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin shows antiangiogenic and antitumor activities [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AHGDM. CAS No. 485395-71-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-133571. | |
| Aminohexylgeldanamycin hydrochloride | Aminohexylgeldanamycin (AHGDM) hydrochloride, a derivative of Geldanamycin, is a heat shock protein 90 (HSP90) inhibitor. Aminohexylgeldanamycin hydrochloride has anti-angiogenic and anti-tumor activities. Synonyms: AHGDM hydrochloride. CAS No. 1146534-45-3. Molecular formula: C34H53ClN4O8. Mole weight: 681.26. | |
| Amlexanox | Antiallergic. Anti-inflammatory. Antagonizes the angiogenic and mitogenic activity of FGF-1 through S100A13. Inhibits FGF-1 release. Binds to HSP90. Inhibits C-terminal chaperone activity. Induces an increase in nonsense-containing mRNAs amount in treated cells, leading to the synthesis of functional full-length proteins in an efficient manner. Selective inhibitor of TANK-binding Kinase 1 (TBK1) and IKKepsilon. Reversibly lowers weight and improves insulin sensitivity and reduces inflammation and attenuated hepatic steatosis in obese mices without affecting food intake. Group: Biochemicals. Alternative Names: 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic Acid; Amoxanox; AA-673; CHX-3673; Aphthasol; Elics; Solfa. Grades: Highly Purified. CAS No. 68302-57-8. Pack Sizes: 25mg, 100mg, 500mg. Molecular Formula: C16H14N2O4, Molecular Weight: 298.29. US Biological Life Sciences. | Worldwide |
| AMP-PCP | AMP-PCP is an ATP analogue and can bind to the N-terminal domain of Hsp90 with a Kd of 3.8 μM. AMP-PCP binding is beneficial to the formation of Hsp90 active homodimer. Synonyms: Phosphomethylphosphonic acid adenylate ester; L-betagamma-meATP; beta,gamma-Methylene ATP; 5'-O-(Hydroxy{[hydroxy(phosphonomethyl)phosphoryl]oxy}phosphoryl)adenosine; 5'-adenylic acid, monohydride with methylenebis(phosphonic acid); 5'-adenylyl (β,γ-methylene)diphosphonate; 9H-Purin-6-amine, 9-[5-O-[hydroxy[[hydroxy(phosphonomethyl)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-. Grade: ≥95%. CAS No. 3469-78-1. Molecular formula: C11H18N5O12P3. Mole weight: 505.21. | |
| BIIB021 | BIIB021 (CNF2024) is an orally active, fully synthetic inhibitor of HSP90 with a K i and an EC 50 of 1.7 nM and 38 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CNF2024. CAS No. 848695-25-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10212. | |
| BIIB 021 | BIIB 021 an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Studies show that BIIB 021 adminisitration led to degradation of Hsp90 client proteins measured in tumor tissue and resulted in the inhibition of tumor growth in several human tumor xenograft models. Group: Biochemicals. Alternative Names: 6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine; 6-Chloro-9-(4-methoxy-3,5-dimethylpyridin-2-ylmethyl)-9H-purin-2-yl]amine. Grades: Highly Purified. CAS No. 848695-25-0. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| C086 | C086 inhibits Hsp90 and BCR-ABL, resulting in decreased proliferation of tumor cells, including imatinib-resistant cells. Synonyms: C086; C 086; C-086. Grade: >98%. CAS No. 1160107-44-7. Molecular formula: C29H28O8. Mole weight: 504.53. | |
| Calenduloside E | Calenduloside E (CE) is a natural pentacyclic triterpenoid saponin extracted from Aralia elata. Calenduloside E (CE) has anti-apoptotic potent by targeting heat shock protein 90 (Hsp90). Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Powder. CAS No. 26020-14-4. Molecular formula: C36H56O9. Mole weight: 632.84. Purity: 0.98. IUPACName: (2S,3S,4S,5R,6R)-6-[[(3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-8a-carboxy-4,4,6a,6b,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid. Canonical SMILES: CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)OC6C(C(C(C(O6)C(=O)O)O)O)O)C)C)C2C1)C)C(=O)O)C. Product ID: ACM26020144. Alfa Chemistry ISO 9001:2015 Certified. |  |
| CCT018159 | CCT018159, a 3,4-diaryl pyrazoleresorcinol, is a ATP-competitive HSP90 ATPase activity inhibitor with IC50s of 3.2 and 6.6 μM for human Hsp90? and yeast Hsp90, respectively. CCT018159 caused cell cytostasis associated with a G1 arrest and induces apoptosis. CCT018159 inhibits key endothelial and tumor cell functions implicated in invasion and angiogenesis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 171009-07-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-110042. | |
| CCT018159 | CCT018159 is a novel inhibitor of heat shock protein (Hsp) 90 with potential anticancer activity. CCT018159 inhibited human Hsp90beta with comparable potency to 17-AAG and with similar ATP-competitive kinetics. The mean cellular GI(50) value of CCT018159 across a panel of human cancer cell lines, including melanoma, was 5.3 mumol/L. CCT018159 caused cell cytostasis associated with a G(1) arrest and induced apoptosis. CCT018159 also inhibited key endothelial and tumor cell functions implicated in invasion and angiogenesis. Synonyms: CCT-018159; CCT 018159. Grade: >98%. CAS No. 171009-07-7. Molecular formula: C20H20N2O4. Mole weight: 352.39. | |
| Celastrol | Celastrol (tripterine) is a novel Hsp90 inhibitor isolated from the root extracts of Tripterygium wilfordii (Thunder god vine) and Celastrus regelii. Celastrol is a pentacyclic triterpenoid and belongs to the family of quinone methides. In in vitro and in vivo animal experiments, celastrol exhibits antioxidant, anti-inflammatory, anticancer, and insecticidal activities. It has been shown to have obesity-controlling effects in mice. Synonyms: Tripterin; Tripterine; (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic Acid; NSC70931; 24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oic acid,3-hydroxy-9,13-dimethyl-2-oxo-, (9b,13a,14b,20a)-; 3-hydroxy-9beta,13alpha-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid. Grade: >98%. CAS No. 34157-83-0. Molecular formula: C29H38O4. Mole weight: 450.61. | |
| CH5015765 | CH5015765 is a novel potent and selective HSP90 inhibitor. CH5015765, which showed high affinity for Hsp90 and antitumor activity in human cancer xenograft mouse models. Synonyms: CH-5015765; CH 5015765; 4-(5-chloro-1,3-dihydrobenzo[de]isochromen-6-yl)-6-(methylthio)-1,3,5-triazin-2-amine. Grade: 98%. CAS No. 959766-47-3. Molecular formula: C16H13ClN4OS. Mole weight: 344.82. | |
| CH5138303 | CH5138303 is a novel and potent Hsp90 inhibitor. CH5138303 showed high binding affinity for N-terminal Hsp90α (Kd = 0.52 nM) and strong in vitro cell growth inhibition against human cancer cell lines (HCT116 IC50=0.098 μM, NCI-N87 IC50=0.066 μM) and also displayed high oral bioavailability in mice (F = 44.0%) and potent antitumor efficacy in a human NCI-N87 gastric cancer xenograft model (tumor growth inhibition=136%). Synonyms: CH-5138303; CH 5138303. Grade: >98%. CAS No. 959763-06-5. Molecular formula: C19H18ClN5O2S. Mole weight: 415.90. | |
| CH5164840 | CH5164840 is a potent and selective HSP90 inhibitor. CH5164840 showed remarkable antitumor activity against NSCLC cell lines and xenograft models. CH5164840 has potent antitumor activity and is highly effective in combination with erlotinib against NSCLC tumors with EGFR overexpression and mutations. Synonyms: CH5164840; CH-5164840; CH 5164840. Grade: 98%. CAS No. 1052645-73-4. Molecular formula: C19H23N5O2S. Mole weight: 385.49. | |
| Chlorobiocin | Chlorobiocin is produced by the strain of Streptomyces hygroscopicus DS 9751 and Novobiocin. Chlorobiocin is found to bind at a second ATP-binding site in the C-terminal domain of Hsp90, thus disrupting the dimerization of the Hsp90 complex. IC50=60 μmol/L. Synonyms: Clorobiocin; Antibiotic RP 18,631; NSC 227186. Grade: >98%. CAS No. 39868-96-7. Molecular formula: C35H37ClN2O11. Mole weight: 697.13. | |
| Coumermycin a1 | Coumemycin A1 is found to bind at a second ATP-binding site in the C-terminal domain of Hsp90, IC50 70 μmol/L. It is produced by the strain of Streptomyces rishirensis, Str. spinichromogene and Str. Spinicoumarensis. It has anti-gram positive bacteria, negative bacteria, mycobacterium (weak) activity, cross-resistance with Novobiocin. Uses: Topoisomerase ii inhibitors. Synonyms: coumermycin a1; COUMERMYCIN; 4434-05-3; Coumamycin; Coumamycine; Coumamycinum; Cumamicina; Sugordomycin D-1a; Coumamycin [INN]; Notomycin; Coumermycin (USAN); Coumermycin [USAN]; Notomycin A1; PCH9QZ1IIH; CHEMBL4555272; NSC 107412; C05073; D02333; Sugordomycin D-la; [(3R,4S,5R,6R)-5-hydroxy-6-[4-hydroxy-3-[[5-[[4-hydroxy-7-[(2R,3R,4S,5R)-3-hydroxy-5-methoxy-6,6-dimethyl-4-(5-methyl-1H-pyrrole-2-ca. Grade: >98%. CAS No. 4434-5-3. Molecular formula: C55H59N5O20. Mole weight: 1110.08. | |
| CPUY201112 | CPUY201112 is an N-terminal Hsp90 inhibitor, which leads to decreased expression of Hsp90 client proteins and may result in increased tumor cell apoptosis. Synonyms: CPUY201112; CPUY 201112; CPUY-201112. Grade: >98%. CAS No. 1860793-58-3. Molecular formula: C19H23N3O4. Mole weight: 357.41. | |
| Cucurbitacin D | Cucurbitacin D is the active ingredient in Trichosanthes kirilowii and can disrupt the interaction between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D is an inflammasome activator. Cucurbitacin D induces cell cycle arrest and cell apoptosis , exhibiting anti-tumor and anti-inflammatory effects [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 3877-86-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N1986. | |
| Dacinostat | Dacinostat, also known as LAQ824, is a hydroxamate histone deacetylase inhibitor with potential anticancer activity. LAQ824 sensitized nonsmall cell lung cancer to the cytotoxic effects of ionizing radiation. LAQ824 reduced clonogenic survival of the H23 and H460 cell lines five-fold compared with controls and four-fold compared with either agent alone (P<0.001). In phase I trials, LAQ824 was well tolerated at doses that induced accumulation of histone acetylation, with higher doses inducing changes consistent with HSP90 inhibition. Synonyms: NVP-LAQ824; NVP LAQ824; LAQ-824; LAQ824; LAQ 824; Dacinostat. CAS No. 404951-53-7. Molecular formula: C22H25N3O3. Mole weight: 379.46. | |
| DDO-5936 | DDO-5936 is a potent Hsp90-Cdc37 PPI inhibitor. DDO-5936 disrupts the Hsp90-Cdc37 interaction, represses cell proliferation through a strong correlation with the Hsp90-Cdc37 expression level, and selectively down-regulates kinase clients of Hsp90. Synonyms: DDO5936; DDO 5936; 2-(2,4,6-trimethyl-N-(4-((2-(pyrrolidin-1-yl)pyrimidin-4-yl)amino)phenyl)phenylsulfonamido)acetic acid. Grade: >98%. CAS No. 2355377-13-6. Molecular formula: C25H29N5O4S. Mole weight: 495.59. | |
| DDO-6600 | DDO-6600 is a heat shock protein (Hsp90) inhibitor. DDO-6600 is identified to covalent modification of Cys598 on Hsp90 from in silico study. Synonyms: (E)-1-(3-(3-(3,4-Dimethylphenyl)-1-phenyl-1H-pyrazol-4-yl)acryloyl)piperidine-2-carboxamide. Grade: 99%. CAS No. 2640292-37-9. Molecular formula: C26H28N4O2. Mole weight: 428.53. | |
| Debio 0932 | Debio 0932, also known as CUDC-305, is a novel Hsp90 inhibitor with strong affinity for Hsp90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L), including many non-small cell lung cancer (NSCLC) cell lines which are resistant to standard-of-care (SOC) agents. Debio 0932 potently inhibits tumour growth in subcutaneous xenograft models of a number of solid and haematological malignancies, including models of NSCLC which harbour mutations conferring acquired or primary erlotinib resistance. Furthermore, Debio 0932 is able to extend animal survival in models of brain metastasis due to its ability to cross the blood-brain barrier, and it enhances the activity of several standard-of-care agents in animal models of cancer. Synonyms: Debio0932; Debio 0932; CUDC-305; CUDC305; CUDC 305. Grade: >98%. CAS No. 1061318-81-7. Molecular formula: C22H30N6O2S. Mole weight: 442.58. | |
| Debio 0932 | Debio 0932 (CUDC-305) is an orally active HSP90 inhibitor, with IC 50 s of 100 and 103 nM for HSP90α and HSP90β, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CUDC-305. CAS No. 1061318-81-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13469. | |
| Degrasyn | Degrasyn, also known as WP1130, is a small molecule that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells and Hsp90/Hsp70 ratios within the cells. WP1130 was more effective in reducing leukemic versus normal hematopoietic colony formation and strongly inhibited colony formation of cells derived from patients with T315I mutant Bcr/Abl-expressing CML in blast crisis. WP1130 suppressed the growth of K562 heterotransplanted tumors as well as both wild-type Bcr/Abl and T315I mutant Bcr/Abl-expressing BaF/3 cells transplanted into nude mice. WP1130 may be useful in treating CML. MM1: IC50 = 1 μM (human); U-266: IC50 = 1.3 μM (human); USP9X: IC50 = 3 μM (human); UCH-L1: IC50 = 3 μM (human); USP5: IC50 = 3 μM (human) In vitro: a partly selective DUB inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37, which are known to regulate survival protein stability and 26S proteasome function; In vivo: suppressed the growth of K562 heterotransplanted tumors as well as both wild-type Bcr/Abl and T315I mutant Bcr/Abl-expressing BaF/3 cells transplanted into nude mice. Uses: Downregulate the antiapoptotic proteins bcr/abl and jak2 and to upregulate the proapoptotic proteins mcl-1 and p53; selective small molecular deubiquitinase (usp5, uch-l1, usp9x, usp14, and uch37) inhibitor mm1: ic50 = 1 & | |
| Deguelin | Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB. Uses: Scientific research. Group: Natural products. Alternative Names: (-)-Deguelin; (-)-cis-Deguelin. CAS No. 522-17-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13425. | |
| Derrubone | Derrubone is a prenylated isoflavone, a type of flavonoid. It was originally isolated from the Indian tree Derris robusta.It has potential application as an inhibitor of Hsp90 to its function as a chaperone protein. Synonyms: 5,7-Dihydroxy-3',4'-methylenedioxy-6-prenylisoflavone. Grade: >98%. CAS No. 22044-58-2. Molecular formula: C21H18O6. Mole weight: 366.37. | |
| Dihydroberberine | Dihydroberberine is a naturally occurring isoquinoline alkaloid with anti-inflammatory, anti-atherosclerotic, hypolipidemic and anti-tumor activities. Dihydroberberine inhibits the human ether-related gene ( hERG ) channel and significantly reduces the expression of heat shock protein 90 ( Hsp90 ) and its interaction with hERG. Dihydroberberine also blocks the TLR4/MyD88/NF-κB signaling pathway to reduce pro-inflammatory cytokines and immunoglobulins, and has inhibitory effects on DSS (HY-116282C)-induced experimental colitis. Dihydroberberine also increases the sensitivity of lung cancer to sunitinib (HY-10255A), with synergistic efficacy [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 483-15-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-N1934. | |
| DP-1 | DP-1, a degradation product of SDC-TRAP-0063, is a fragment of Ganetespib. Ganetespib is a heat shock protein 90 (HSP90) inhibitor with anti-tumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1472616-61-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132995. | |
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