Hydroxy Camptothecin Suppliers USA
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Product | Description | |
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10-Hydroxy Camptothecin Quick inquiry Where to buy Suppliers range | A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy. Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-4, 9-dihydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione; (S)-10-Hydroxycamptothecin; Hydroxycamptothecin; NSC 107124. Grades: Highly Purified. CAS No. 19685-09-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
10-Hydroxy Camptothecin Quick inquiry Where to buy Suppliers range | 10-Hydroxy Camptothecin. Uses: For analytical and research use. Group: Chiral Molecules. Alternative Names: (S)-10-Hydroxycamptothecin, SKF-S-104961, Hydroxycamptothecin, (+)-10-Hydroxycamptothecin, (S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3'4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (4S)-, 10-Hydroxycamptothecine, Camptothecine, 10-hydroxy- (8CI), Topotecan related, 10-Hydroxycamptothecin, 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (S)-, NSC 107124, ChEMBL 273862. CAS No. 19685-09-7. Pack Sizes: 1MG. IUPAC Name: (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione. Molecular formula: C20H16N2O5. Mole weight: 364.35. Catalog: APS19685097A. SMILES: CC[C@@]1 (O)C (=O)OCC2=C1C=C3N (Cc4cc5cc (O)ccc5nc34)C2=O. Format: Neat. Product Type: Impurity. Shipping: Room Temperature. | |
10-Hydroxy Camptothecin 9,9-Methylene Dimer Quick inquiry Where to buy Suppliers range | 10-Hydroxy Camptothecin 9,9-Methylene Dimer, is a 10-Hydroxy Camptothecin (H875000) impurity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
7-Ethyl-10-Hydroxy-Camptothecin Quick inquiry Where to buy Suppliers range | 7-Ethyl-10-Hydroxy-Camptothecin. Group: Biochemicals. Alternative Names: 10-Hydroxy-7-ethylcamptothecin; 7-Ethyl-10-hydroxy-20(S)-camptothecin. Grades: Plant Grade. CAS No. 86639-52-3. Pack Sizes: 20mg. Molecular Formula: C22H20N2O5, Molecular Weight: 392.405. US Biological Life Sciences. | Worldwide |
9-Hydroxymethyl-10-hydroxy Camptothecin Quick inquiry Where to buy Suppliers range | 9-Hydroxymethyl-10-hydroxy Camptothecin. Uses: For analytical and research use. Group: Chiral Molecules. Alternative Names: 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-10-(hydroxymethyl)-, (S)- (9CI). CAS No. 175613-38-4. Pack Sizes: 1MG. Molecular formula: C21H18N2O6. Mole weight: 394.38. Catalog: APS175613384. SMILES: CC[C@@]1 (O)C (=O)OCC2=C1C=C3N (Cc4cc5c (CO)c (O)ccc5nc34)C2=O. Format: Neat. Shipping: Room Temperature. | |
9-Hydroxymethyl-10-hydroxy Camptothecin Quick inquiry Where to buy Suppliers range | 9-Hydroxymethyl-10-hydroxy Camptothecin, is a metabolite of Camptothecin (C175150), which is a topoisomerase inhibitor for cancer therapy. Group: Biochemicals. Alternative Names: p(S)-4-Ethyl-4, 9-dihydroxy-10-(hydroxymethyl)-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. CAS No. 175613-38-4. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
9-Propoxymethyl-10-hydroxy Camptothecin Quick inquiry Where to buy Suppliers range | 9-Propoxymethyl-10-hydroxy Camptothecin, is a substituted derivative of Camptothecin (C175150), which is a topoisomerase inhibitor used for the treatment of human cancers. Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-4, 9-dihydroxy-10-(propoxymethyl)-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. CAS No. 1379512-11-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
9-Propoxymethyl-10-hydroxy Camptothecin Quick inquiry Where to buy Suppliers range | 9-Propoxymethyl-10-hydroxy Camptothecin. Uses: For analytical and research use. Group: Chiral Molecules; Enzyme Activators, Inhibitors & Substrates. CAS No. 1379512-11-4. Pack Sizes: 5MG. Molecular formula: C24H24N2O6. Mole weight: 436.46. Catalog: APS1379512114. SMILES: CCCOCc1c (O)ccc2nc3C4=CC5=C (COC (=O)[C@]5 (O)CC)C (=O)N4Cc3cc12. Format: Neat. Shipping: Room Temperature. | |
(R)-7-Ethyl-10-Hydroxy Camptothecin Quick inquiry Where to buy Suppliers range | R-Enantiomer of SN-38. Used for making the bioconjugates and bifunctional isocyanate cross linking reagents. Synonyms: (4R)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione. Grades: > 95%. CAS No. 647852-82-2. Molecular formula: C22H20N2O5. Mole weight: 392.42. | |
10-Hydroxy Camptothecin-d5 Quick inquiry Where to buy Suppliers range | 10-Hydroxy Camptothecin-d5. Uses: For analytical and research use. Group: Chiral Molecules. Pack Sizes: 1MG. Catalog: APS014140. Format: Neat. Product Type: Stable Isotope Labelled. Shipping: Room Temperature. | |
10-Hydroxy Camptothecin-d5 Quick inquiry Where to buy Suppliers range | A labeled Camptothecin derivative; a topoisomerase inhibitor for cancer therapy. Group: Biochemicals. Alternative Names: (4S)-4-(Ethyl-d5)-4, 9-dihydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione; (S)-10-Hydroxycamptothecin-d5; Hydroxycamptothecin-d5; NSC 107124-d5. Grades: Highly Purified. CAS No. 1330277-66-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
(S)-(+)-Camptothecin ((S)-4-Ethyl-4-hydroxy-1H-pyrano[3, 4:6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione) Quick inquiry Where to buy Suppliers range | Binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent. Group: Biochemicals. Alternative Names: (S)-4-Ethyl-4-hydroxy-1H-pyrano[3, 4:6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
10-Hydroxy-9-[ (dimethylamino)methyl]-5-ethoxy- (20S, 5RS)-camptothecin Quick inquiry Where to buy Suppliers range | 10-Hydroxy-9-[ (dimethylamino)methyl]-5-ethoxy- (20S, 5RS)-camptothecin is an impurity of Topotecan (T542500), a chemotherapy agent that is a topoisomerase 1 inhibitor. Group: Biochemicals. Alternative Names: (4S)-10-[ (Dimethylamino)methyl]-12-ethoxy-4-ethyl-4, 9-dihydroxy-1H-pyrano[3', 4': 6, 7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione. Grades: Highly Purified. CAS No. 504413-76-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
10-Hydroxy-11-methoxycamptothecin Quick inquiry Where to buy Suppliers range | 10-Hydroxy-11-methoxycamptothecin can be obtained from (S)-(+)-Camptothecin (C175150) which is an antitumor alkaloid. It binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C21H18N2O6, Molecular Weight: 394.38. US Biological Life Sciences. | Worldwide |
10-Hydroxy-11-methoxycamptothecin-d3 Quick inquiry Where to buy Suppliers range | 10-Hydroxy-11-methoxycamptothecin-d3 is the labelled version of 10-Hydroxy-11-methoxycamptothecin (H949833) which can be obtained from (S)-(+)-Camptothecin (C175150) which is an antitumor alkaloid. It binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C21H15D3N2O6, Molecular Weight: 397.4. US Biological Life Sciences. | Worldwide |
11-Desethyl Irinotecan Quick inquiry Where to buy Suppliers range | 11-Desethyl Irinotecan. Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates; Impurity Standards. Alternative Names: [1,4'-Bipiperidine]-1'-carboxylic acid, 4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester, (S)-, 10-[4-(1-Piperidino)-1-piperidinocarbonyloxy]camptothecin, 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline, [1,4'-bipiperidine]-1'-carboxylic acid deriv., 11-Desethyl irinotecan, (4S)-4-Ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 1,4'-bipiperidine-1'-carboxylate,[1,4'-Bipiperidine]-1'-carboxylic acid, (4S)-4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester, (4S)-4-Ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate. CAS No. 103816-16-6. Molecular formula: C31H34N4O6. Mole weight: 558.62. Catalog: APS103816166. SMILES: CC[C@@]1 (O)C (=O)OCC2=C1C=C3N (Cc4cc5cc (OC (=O)N6CCC (CC6)N7CCCCC7)ccc5nc34)C2=O. Format: Neat. Product Type: Impurity. | |
11-Desethyl Irinotecan Quick inquiry Where to buy Suppliers range | 11-Desethyl Irinotecan is an impurity of the DNA topoisomerase inhibitor Irinotecan (I767500). Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-3, 4, 12, 14-tetrahydro-4-hydroxy-3, 14-dioxo-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinolin-9-yl Ester [1,4'-Bipiperidine]-1'-carboxylic Acid; 1H-Pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline, [1,4'-Bipiperidine]-1'-carboxylic Acid deriv.; 10- [4- (1-Piperidino) -1-piperidinocarbonyloxy] camptothecin. Grades: Highly Purified. CAS No. 103816-16-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
11-Desethyl Irinotecan-d10 Quick inquiry Where to buy Suppliers range | 11-Desethyl Irinotecan-d10. Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-3, 4, 12, 14-tetrahydro-4-hydroxy-3, 14-dioxo-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinolin-9-yl Ester [1,4'-Bipiperidine]-1'-carboxylic Acid-d10; 1H-Pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline, [1,4'-Bipiperidine]-1'-carboxylic Acid deriv.-d10; 10- [4- (1-Piperidino) -1-piperidinocarbonyloxy] camptothecin-d10. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C31H24D10N4O6, Molecular Weight: 568.69. US Biological Life Sciences. | Worldwide |
11-Ethyl camptothecin Quick inquiry Where to buy Suppliers range | 11-Ethyl camptothecin. Group: Biochemicals. Alternative Names: (4S)-4, 8-Diethyl-4-hydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. CAS No. 185807-29-8. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C22H20N2O4. US Biological Life Sciences. | Worldwide |
1-(2-Amino-5-hydroxyphenyl)propan-1-one Quick inquiry Where to buy Suppliers range | 1-(2-Amino-5-hydroxyphenyl)propan-1-one is a useful synthetic intermediate. It is used in the asymmetrical synthesis of (S)-4-ethyl-6,7,8,10- tetrahydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione, a key intermediate for synthesis of irinotecan and other camptothecin analogs. It is also used in the synthesis of E-?ring-?modified (RS)?-?camptothecin analogs as antitumor agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 35364-15-9. Pack Sizes: 250mg, 2.5g. Molecular Formula: C9H11NO2. US Biological Life Sciences. | Worldwide |
1',4',7',8'-Tetrahydro-4'-hydroxy-4'-methylspiro[1,3-dioxolane-2,6'(10'H)-[3H]pyrano[3,4-f]indolizine]-3',10'-dione Quick inquiry Where to buy Suppliers range | 1',4',7',8'-Tetrahydro-4'-hydroxy-4'-methylspiro[1,3-dioxolane-2,6'(10'H)-[3H]pyrano[3,4-f]indolizine]-3',10'-dione is a key intermediate in the synthesis of camptothecin (C175150) analogues. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C14H15NO6. US Biological Life Sciences. | Worldwide |
20-Desethyl-20-methyl-10-hydroxy-7-ethylcamptothecin Quick inquiry Where to buy Suppliers range | 20-Desethyl-20-methyl-10-hydroxy-7-ethylcamptothecin is an intermediate in the synthesis of Irinotecan Hydrochloride (I767500), a DNA topoisomerase inhibitor and also a derivative of Camptothecin (C175145), an antitumor alkaloid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C21H18N2O5. US Biological Life Sciences. | Worldwide |
20r-Camptothecin Quick inquiry Where to buy Suppliers range | 20r-Camptothecin. Group: Heterocyclic Organic Compound. Alternative Names: (R)-(-)-Camptothecin;(R)-(-)-Camptothecine;(R)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(R)-Camptothecin;20R-Camptothecin;(4R)-4β-Ethyl-4-hydroxy-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione. CAS No. 110351-92-3. Molecular formula: C20H16N2O4. Mole weight: 348.35204. | |
2-Hydroxy-2- (6'- (hydroxymethyl) -5'-oxo-3', 5', 8', 8a'-tetrahydro-2'H-spiro[[1, 3]dioxolane-2, 1'-indolizin]-7'-yl) -N- ( (S) -1-phenylethyl) propanamide Quick inquiry Where to buy Suppliers range | 2-Hydroxy-2- (6'- (hydroxymethyl) -5'-oxo-3', 5', 8', 8a'-tetrahydro-2'H-spiro[[1, 3]dioxolane-2, 1'-indolizin]-7'-yl) -N- ( (S) -1-phenylethyl) propanamide is an intermediate in the synthesis of Irinotecan Hydrochloride (I767500), a DNA topoisomerase inhibitor and also a derivative of Camptothecin (C175145), an antitumor alkaloid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C22H28N2O6. US Biological Life Sciences. | Worldwide |
4'-Ethyl-7',8'-dihydro-4'-hydroxy-spiro[1,3-dioxolane-2,6'(3'H)-[1H]pyrano[3,4-f]indolizine]-3',10'(4'H)-dione-d5 Quick inquiry Where to buy Suppliers range | Used in the preparation of Camptothecin and Homocamptothecin derivatives, for their therapeutic use as antitumor agents. Group: Biochemicals. Alternative Names: (±)-4'-Ethyl-7',8'-dihydro-4'-hydroxy-spiro[1,3-dioxolane-2,6'(3'H)-[1H]pyrano[3,4-f]indolizine]-3',10'(4'H)-dione-d5. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
(4S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione-d5 Quick inquiry Where to buy Suppliers range | Used in the preparation of Camptothecin derivatives, for their therapeutic use as antitumor agents. Group: Biochemicals. Alternative Names: (S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione-d5; (4S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
(4S)-9-(Acetyloxy)-10-[(acetyloxy)methyl]-4-ethyl-4-hydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione Quick inquiry Where to buy Suppliers range | (4S)-9-(Acetyloxy)-10-[(acetyloxy)methyl]-4-ethyl-4-hydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione is an intermediate in the synthesis of Camptothecin analogs for the inhibition of topoisomerase I and antitumor activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 1304788-26-8. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
5-Hydroxy Topotecan-d6 Quick inquiry Where to buy Suppliers range | 5-Hydroxy Topotecan-d6. Group: Biochemicals. Alternative Names: (4S)-10-[ (Dimethylamino)methyl]-4-ethyl-4, 9, 12-trihydroxy-1H-Pyrano[3', 4': 6, 7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione-d6; 10-Hydroxy-9-[ (dimethylamino)methyl]-5-hydroxy- (20S, 5RS)-camptothecin-d6. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C23H17D6N3O6, Molecular Weight: 443.48. US Biological Life Sciences. | Worldwide |
5-Hydroxy Topotecan Dihydrochloride (Mixture of Diastereomers) Quick inquiry Where to buy Suppliers range | 5-Hydroxy Topotecan Dihydrochloride (Mixture of Diastereomers). Uses: For analytical and research use. Group: Chiral Molecules; Enzyme Activators, Inhibitors & Substrates. Alternative Names: 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9,12-trihydroxy-, (4S)-, (4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9,12-trihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-Hydroxy-9-[(dimethylamino)methyl]-5-hydroxy-(20S,5RS)-camptothecin. CAS No. 504413-73-4. Molecular formula: C23H23N3O6. Mole weight: 437.45. Catalog: APS504413734. SMILES: CC[C@@]1 (O)C (=O)OCC2=C1C=C3N (C (O)c4cc5c (CN (C)C)c (O)ccc5nc34)C2=O. Format: Neat. | |
5-Hydroxy Topotecan Dihydrochloride Salt (Mixture of Diastereomers) Quick inquiry Where to buy Suppliers range | Dihydrochloride Salt of 5-Hydroxy Topotecan, is the metabolite of Topotecan (T542500), which is a DNA topoisomerase I inhibitor, semi synthetic analog of Camptothecin, and an antineoplastic. Group: Biochemicals. Alternative Names: (4S)-10-[ (Dimethylamino)methyl]-4-ethyl-4, 9, 12-trihydroxy-1H-Pyrano[3', 4': 6, 7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione Dihydrochloride Salt; 10-Hydroxy-9-[ (dimethylamino)methyl]-5-hydroxy- (20S, 5RS)-camptothecin Dihydrochloride Salt. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
7-Ethyl Camptothecin Quick inquiry Where to buy Suppliers range | The main reasons for the superior antitumor activity of 7-Ethylcamptothecin compared with CPT are as follows: (a) 7-Ethylcamptothecin had a stronger growth-inhibiting activity against tumor cells, and (b) 7-Ethylcamptothecin remained in the intestinal tract for a longer time and in higher amounts when administered in vivo. 7-Ethyl Camptothecin is a natural compound found in the barks of Camptotheca acuminata Decne, it can be used as a cosmetics material. Synonyms: (S)-4,11-Diethyl-4-hydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione; 7-ethylcamptothecin; (4S)-4,11-diethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; Irinotecan EP Impurity F. Grades: >98%. CAS No. 78287-27-1. Molecular formula: C22H20N2O4. Mole weight: 376.42. | |
7-Ethyl Camptothecin Quick inquiry Where to buy Suppliers range | An anticancer drug, showed strong activity against various murine tumors. A Camptothecin (CPT) derivative as antineoplastic agent against drug-resistant tumors. Group: Biochemicals. Alternative Names: (4S)-4, 11-Diethyl-4-hydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione; 7-Ethyl-20(S)-camptothecin; SN 22. Grades: Highly Purified. CAS No. 78287-27-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
7-Ethyl-d3-camptothecin Quick inquiry Where to buy Suppliers range | An anticancer drug, showed strong activity against various murine tumors. A Labeled camptothecin(CPT) derivative as antineoplastic agent against drug-resistant tumors. Group: Biochemicals. Alternative Names: (4S)-4, 11-Diethyl-4-hydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione-d3; 7-Ethyl-d3-20(S)-camptothecin; SN 22-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
7-Methyl Camptothecin. Quick inquiry Where to buy Suppliers range | Camptothecin analog as DNA topoisomerase I inhibitors: a QSAR study. It may also be useful in the design and development of new camptothecin derivatives as DNA topoisomerase I (topo I) inhibitors. A poorly water soluble camptothecin analogue. Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-4-hydroxy-11-methyl-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)dione; 7-Methyl-20(S)-camptothecin; 7-Methylcamptothecin. Grades: Highly Purified. CAS No. 78287-26-0. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
9-Aminocamptothecin Quick inquiry Where to buy Suppliers range | 9-Aminocamptothecin (9-Amino-CPT) is a topoisomerase I inhibitor with potent anticancer activity. Group: Biobased Products. Alternative Names: 9-Amino-20-(S)-camptothecin. Grades: 98%. CAS No. 91421-43-1. Product ID: BBC91421431. Molecular formula: C20H17N3O4. Mole weight: 363.37. IUPAC Name: (19S)-8-amino-19-ethyl-19-hydroxy-17-oxa-3, 13-diazapentacyclo[11.8.0.02, 11.04, 9.015, 20]henicosa-1(21), 2, 4, 6, 8, 10, 15(20)-heptaene-14, 18-dione. Appearance: Powder. Density: 1.55±0.1 g/ml. SMILES: CC[C@@]1 (C2=C (COC1=O)C (=O)N3CC4=CC5=C (C=CC=C5N=C4C3=C2)N)O. | |
9-Amino Camptothecin Carboxylate Sodium Salt Quick inquiry Where to buy Suppliers range | 9-Amino Camptothecin Carboxylate Sodium Salt. Group: Biochemicals. Alternative Names: (S)-1-Amino-α-ethyl-9,11-dihydro-α-hydroxy-8-(hydroxymethyl)-9-oxo-indolizino[1,2-b]quinoline-7-acetic Acid Sodium Salt. Grades: Highly Purified. Pack Sizes: 2.5mg. Molecular Formula: C20H18N3NaO5, Molecular Weight: 403.36. US Biological Life Sciences. | Worldwide |
Camptothecin Quick inquiry Where to buy Suppliers range | Camptothecin. Group: Biochemicals. Alternative Names: (S)-4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; Camptothecine. Grades: Highly Purified. CAS No. 7689-3-4. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C20H16N2O4. US Biological Life Sciences. | Worldwide |
Camptothecin sodium Quick inquiry Where to buy Suppliers range | An alkaloid topoisomerase I (topo I) inhibitor with anticancer properties. It is isolated from camptotheca acuminata, a deciduous tree or nothapodytes foetida. Synonyms: 20(S)-Camptothecin Sodium Salt; Camptothecine Sodium; NSC 100880; Sodium Camptothecin; (αS)-α-ethyl-9,11-Dihydro-α-hydroxy-8-(hydroxymethyl)-9-oxo-indolizino[1,2-b]quinoline-7-acetic Acid Monosodium Salt; 21,22-Secocamptothecin-21-oic Acid Monosodium Salt. Grades: ≥95%. CAS No. 25387-67-1. Molecular formula: C20H17N2NaO5. Mole weight: 388.35. | |
CKD 602 Quick inquiry Where to buy Suppliers range | CKD-602 is a topoisomerase I inhibitor. It is a synthetic and water-soluble camptothecin derivative which forms stable DNA-topoisomerase complexes during DNA replication and induces cell cycle arrest in the G2/M phase. CKD-602 has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group. Synonyms: (4S)-4-Ethyl-4-hydroxy-11-[2-[(1-methylethyl)amino]ethyl]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione phosphate; Belotecan hydrochloride. Grades: ≥98% by HPLC. CAS No. 213819-48-8. Molecular formula: C25H27N3O4·H3PO4. Mole weight: 531.49. | |
Diflomotecan Quick inquiry Where to buy Suppliers range | Diflomotecan is an E-ring modified camptothecin analogue, which possesses greater lactone stability in plasma compared with other topoisomerase I inhibitors. Diflomotecan is also a 10,11-difluoro-homocamptothecin, represents a new promising class of topoisomerase I inhibitors with enhanced plasma stability and superior preclinical anti-tumour activity as compared to the established camptothecins, irinotecan and topotecan. Diflomotecan was the first homocamptothecin to enter clinical studies. Phase I data are summarized for both the intravenous and oral schedules. The toxicity is primarily haematological while no severe gastrointestinal toxicity has been observed in contrast to other topoisomerase I inhibitors. Diflomotecan has a high oral bioavailability (72 - 95%) and the oral day 1 - 5 every 3 weeks regimen is recommended for Phase II testing because it is relatively well tolerated, convenient and mimics protracted exposure. Synonyms: BN 80915; 3H,15H-Oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione, 5-ethyl-9,10-difluoro-1,4,5,13-tetrahydro-5-hydroxy-, (5R)-; (5R)-5-Ethyl-9,10-difluoro-1,4,5,13-tetrahydro-5-hydroxy-3H,15H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione; (R)-5-Ethyl-9, 10-difluoro-5-hydroxy-4, 5-dihydrooxepino[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 15(1H, 13H)-dione. Grades: ≥95%. CAS No. 220997-97-7. Molecular formula: C21H16F2N2O4. Mole weight: 398.36. | |
Elomotecan Quick inquiry Where to buy Suppliers range | Elomotecan (BN-80927) belongs to a novel family of camptothecin analogs, the homocamptothecins, developed on the concept of topoisomerase I (Topo I) inhibition and characterized by a stable seven-membered beta-hydroxylactone ring. Preclinical data reported here show that BN80927 retains Topo I poisoning activity in cell-free assay (DNA relaxation) as well as in living cells, in which in vivo complexes of topoisomerase experiments and quantification of DNA-protein-complexes stabilization, have confirmed the higher potency of BN80927 as compared with the Topo I inhibitor SN38. In addition, BN80927 inhibits Topo II-mediated DNA relaxation in vitro but without cleavable-complex stabilization, thus indicating catalytic inhibition. Moreover, a Topo I-altered cell line (KBSTP2), resistant to SN38, remains sensitive to BN80927, suggesting that a part of the antiproliferative effects of BN80927 are mediated by a Topo I-independent pathway. This hypothesis is also supported by in vitro data showing an antiproliferative activity of BN80927 on a model of resistance related to the noncycling state of cells (G(0)-G(1) synchronized). In cell growth assays, BN80927 is a very potent antiproliferative agent as shown by IC(50) values consistently lower than those of SN38 in tumor cell lines as well as in their related drug-resistant lines. BN80927 shows high efficiency in vivo in tumor xenograft studies using human androgen-independent prostate tumors PC3 and DU145. Altogether, these data strongly support the clinical development of BN80927. Synonyms: BN-80927; BN80927; BN 80927; R-1559; R1559; R 1559; (R)-9-chloro-5-ethyl-5-hydroxy-10-methyl-12-((4-methylpiperidin-1-yl)methyl)-4, 5-dihydrooxepino[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 15(1H, 13H)-dione. CAS No. 220998-10-7. Molecular formula: C29H32ClN3O4. Mole weight: 522.04. | |
Etirinotecan pegol Quick inquiry Where to buy Suppliers range | Etirinotecan pegol, also know as pegylated irinotecan, NKTR102, is a formulation of polyethylene glycol (PEG)-encapsulated irinotecan with antineoplastic activity. The prodrug irinotecan, a semisynthetic derivative of camptothecin, is converted to the biologically active metabolite 7-ethyl-10-hydroxy-camptothecin by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, 7-ethyl-10-hydroxy-camptothecin inhibits topoisomerase I activity by stabilizing the cleavable complex of topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptosis. Pegylation provides improved drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic effects while lowering the toxicity profile. Synonyms: NKTR102; NKTR 102; NKTR-102; pegylated irinotecan NKTR 102; Etirinotecan pegol. CAS No. 1193151-09-5. Molecular formula: C161H196Cl4N20O40. Mole weight: 3193.24. | |
Gimatecan Quick inquiry Where to buy Suppliers range | Gimatecan is an orally bioavailable, semi-synthetic lipophilic analogue of camptothecin, a quinoline alkaloid extracted from the Asian tree Camptotheca acuminate, with potential antineoplastic and antiangiogenic activities. Gimatecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Although the mechanism of its antiangiogenic activity has yet to be full elucidated, this agent may inhibit endothelial cell migration, tumor neovascularization, and the expression of proangiogenic basic fibroblast growth factor (bFGF). Synonyms: ST1481; 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-11-carboxaldehyde, 4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-, 11-(O-(1,1-dimethylethyl)oxime), (C(E),4S)-; 7-t-Butoxyiminomethylcamptothecin; (4S)-11-((E)-((1,1-DImethylethoxy)imino)methyl)-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H)-dione; NSC793724. Grades: ≥98%. CAS No. 292618-32-7. Molecular formula: C25H25N3O5. Mole weight: 447.48. | |
Irinotecan, Hydrochloride Salt, Trihydrate ([1,4-Bipiperidine]-1-carboxylic Acid (S)-4, 11-diethyl-3, 4, 12, 14-tetrahydro-4-hydroxy-3, 14-dioxo-1H-pyrano[3, 4, 6, 7]indolizino[1, 2-b]quinolin-9-yl Ester, HCl Trihydrate) Quick inquiry Where to buy Suppliers range | Irinotecan (CPT-11) is a topoisomerase I inhibitor. It is a semisynthetic analog of the natural alkaloid camptothecin and has an active metabolite SN-38 (7-Ethyl-10-hydroxycamptothecin). During the S phase of the cell cycle, camptothecins selectively bind to and stabilize topoisomerase I-DNA complexes, inhibiting religation, causing the accumulation of topoisomerase I-mediated single-strand DNA breaks in the DNA, and producing irreversible double-strand DNA breaks that lead to cell death. Group: Biochemicals. Grades: Highly Purified. CAS No. 136572-09-3. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
Irinotecan Hydrochloride Trihydrate Quick inquiry Where to buy Suppliers range | The hydrochloride salt of Irinotecan. Irinotecan is a prodrug that can be activated to 7-ethyl-10-hydroxy-camptothecin (SN-38) by the carboxylesterase-converting enzyme. SN-38 inhibits topoisomerase I to suppress DNA replication and promote cell death. Synonyms: CPT-11 HCl Trihydrate; CPT 11 HCl Trihydrate; CPT11 HCl Trihydrate; Irinotecan Hcl Trihydrate; UNII-042LAQ1IIS. Grades: >98%. CAS No. 136572-09-3. Molecular formula: C33H38N4O6.HCl.3H2O. Mole weight: 677.18. | |
Karenitecin Quick inquiry Where to buy Suppliers range | Karenitecin, also known as Cositecan, is a synthetic silicon-containing agent related to camptothecin with antineoplastic properties. Karenitecin stabilizes the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks and consequently triggering apoptosis. Because it is lipophilic, karenitecin exhibits enhanced tissue penetration and bio-availability compared to water-soluble camptothecins. Synonyms: Cositecan; BNP 1350; (4S)-4-Ethyl-4-hydroxy-11-[2-(trimethylsilyl)ethyl]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 7-[2-(Trimethylsilyl)ethyl]camptothecin; DB 172; MCC 12824; (S)-4-ethyl-4-hydroxy-11-(2-(trimethylsilyl)ethyl)-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-11-[2-(trimethylsilyl)ethyl]-, (4S)-. Grades: ≥98%. CAS No. 203923-89-1. Molecular formula: C25H28N2O4Si. Mole weight: 448.59. | |
Lurtotecan Quick inquiry Where to buy Suppliers range | liposomal lurtotecan is a liposome-encapsulated formulation of lurtotecan with antineoplastic activity. Lurtotecan, a semisynthetic analogue of camptothecin, selectively stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex during S phase of the cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-stranded DNA breaks. This ultimately results in an inhibition of DNA replication, inducing double-stranded DNA breakages, obstruction of RNA and protein synthesis and triggering apoptosis. Furthermore, this agent also stimulates degradation of topoisomerase I, likely mediated through ubiquitin-proteasomal pathway. Liposomal delivery of lurtotecan improves its penetration and delivery into tumors while lowering systemic side effects. Synonyms: OSI-221; OSI 221; OSI221; NX211; NX 211; NX-211; (S)-8-ethyl-8-hydroxy-15-((4-methylpiperazin-1-yl)methyl)-11,14-dihydro-2H-[1,4]dioxino[2,3-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-9,12(3H,8H)-dione. CAS No. 149882-10-0. Molecular formula: C28H30N4O6. Mole weight: 518.57. | |
Namitecan Quick inquiry Where to buy Suppliers range | Namiteca is a new water-soluble camptothecin analogue as a hydrophilic camptothecin with a promising preclinical profile. Uses: Dna topoisomerase i inhibitors. Synonyms: ST-1968; ST 1968; ST1968; Namitecan.(4S)-11-((E)-((2-Aminoethoxy)imino)methyl)-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H)-dione. Grades: ≥98%. CAS No. 372105-27-6. Molecular formula: C23H22N4O5. Mole weight: 434.45. | |
rac-4,11-Diethyl-9-hydroxycamptothecin Quick inquiry Where to buy Suppliers range | Synonyms: 1H-Pyrano[3',?4':6,?7]?indolizino[1,?2-b]?quinoline-3,?14(4H,?12H)?-dione, 4,?11-diethyl-4,?9-dihydroxy-; (rac)-7-Ethyl-10-Hydroxy Camptothecin. Grades: >95%. CAS No. 130144-34-2. Molecular formula: C22H20N2O5. Mole weight: 392.411. | |
Rubitecan Quick inquiry Where to buy Suppliers range | Rubitecan is a semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells. This agent also prevents repair of reversible single-strand DNA breaks. Synonyms: RFS 2000; 9-Nitrocamptothecin; (4S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizinol[1,2-b]quinoline-3,14(4H,12H)-dione; 9-NC; Orathecin; 9-nitro-20(S)-camptothecin; Camptogen; (S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 9-nitro-CPT; Nitrocamptothecin. Grades: ≥98%. CAS No. 91421-42-0. Molecular formula: C20H15N3O6. Mole weight: 393.35. | |
Rubitecan ((4S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3, 4:6, 7]indolizinol[1, 2-b]quinoline-3, . 14(4H,-12H)-dione, 9-Nitrocamptothecin, 9-NC, Orathecin) Quick inquiry Where to buy Suppliers range | Semisynthetic camptothecin which inhibits DNA topoisomerase I. Prodrug of 9-aminocamptothecin. Antineoplastic. Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3, 4:6, 7]indolizinol[1, 2-b]quinoline-3, 14(4H, -12H)-dione; 9-Nitrocamptothecin; 9-NC; Orathecin. Grades: Highly Purified. CAS No. 91421-42-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
(S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione Quick inquiry Where to buy Suppliers range | (S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione is a key intermediate in the synthesis of Exatecan, Irinotecan and Camptothecin analogs. Synonyms: (4S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione; (S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione; 1H-Pyrano[3,4-f]indolizine-3,6,10(4H)-trione, 4-ethyl-7,8-dihydro-4-hydroxy-, (4S)-. Grades: ≥95%. CAS No. 110351-94-5. Molecular formula: C13H13NO5. Mole weight: 263.25. | |
SN-38 Glucuronide Quick inquiry Where to buy Suppliers range | A metabolite of Irinotecan. Synonyms: 7-Ethyl-10-hydroxy-camptothecin-10-O-b-Dglucuronide; (4S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl b-D-glucopyranosiduronic acid. Grades: > 95%. CAS No. 121080-63-5. Molecular formula: C28H28N2O11. Mole weight: 568.53. | |
(S)-Topotecan Quick inquiry Where to buy Suppliers range | (S)-Topotecan. Uses: For analytical and research use. Group: Chiral Molecules; Enzyme Activators, Inhibitors & Substrates. Alternative Names: TopoCED, Topophore C, 9-(N,N-Dimethylaminomethyl)-10-hydroxycamptothecin, Topotecan lactone,1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (4S)-, SKF 104864, Hycamptin, Nogitecan, Hycamptamine, NSC 609699, 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (S)-, (S)-Topotecan, Topotecan, 10-Hydroxy-9-[(dimethylamino)methyl]-(20S)-camptothecin, SKF-S 104864, (4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione. CAS No. 123948-87-8. Molecular formula: C23H23N3O5. Mole weight: 421.45. Catalog: APS123948878. SMILES: CC[C@@]1 (O)C (=O)OCC2=C1C=C3N (Cc4cc5c (CN (C)C)c (O)ccc5nc34)C2=O. Format: Neat. |