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An antimalarial; antirheumatic; lupus erythematosus suppressant. Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer.2 Hydroxychloroquine is an aminoquinoline like chloroquine. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus.12 Hydroxychloroquine is also used for the prophylaxis of malaria in regions where chloroquine resistance is unlikely. It was developed during World War II as a derivative of quinacrine with less severe side effects. Chloroquine and hydroxychloroquine are both being investigated for the treatment of SARS-CoV-2. Hydroxychloroquine was granted FDA approval on 18 April 1955. Hydroxychloroquine is indicated for the prophylaxis of malaria where chloroquine resistance is not reported, treatment of uncomplicated malaria (caused by P. falciparum, P. malariae, P. ovale, or P. vivax), chronic discoid lupus erythematosus, system Group: Biochemicals. Alternative Names: 2-[{4-[ (7-Chloroquinolin-4-yl)amino]pentyl} (ethyl)amino]ethanol; 7-Chloro-4-[4-[ethyl(2-hydroxyethyl)amino]-1-methylbutylamino]-quinoline; Plaquenil; Oxichloroquine; Oxychloro. Grades: Highly Purified. CAS No. 118-42-3. Pack Sizes: 10mg, 50mg, 100mg. Molecular Formula: C??H??ClN?O, Molecular Weight: 335.87. US Biological Life Sciences.
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Hydroxychloroquine
Hydroxychloroquine (HCQ) is a synthetic oral antimalarial drug that can be used in the study of malaria and autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. Hydroxychloroquine is a potent autophagic flux inhibitor with antiviral activity (such as SARS-CoV-2 virus) that inhibits Toll-like receptor 7/9 ( TLR7/9 ) signaling [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Signaling pathways. CAS No. 118-42-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg. Product ID: HY-W031727.
Hydroxychloroquine
Hydroxychloroquine is a synthetic antimalarial agent and it can inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine efficiently inhibits SARS-CoV-2 infection in vitro. Uses: Antimalarials. Synonyms: Plaquenil; Oxichloroquine; Polirreumin; 7-Chloro-4-(4-(ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline; WIN 1258; Win 1258-2. Grades: ≥97%. CAS No. 118-42-3. Molecular formula: C18H26ClN3O. Mole weight: 335.87.
Hydroxychloroquine-d4 Sulfate
An antimalarial; antirheumatic; lupus erythematosus suppressant. It is a COVID19-related research product. Group: Biochemicals. Alternative Names: 2- [ [4- [ (7-Chloro-4-quinolinyl) amino] pentyl] ethylamino-d4] ethanol Sulfate; 7-Chloro-4-[4-[ethyl-d4(2-hydroxyethyl)amino]-1-methylbutylamino]-quinoline Sulfate; Ercoquin-d4; Plaquenil-d4 Sulfate; Quensyl-d4. Grades: Highly Purified. CAS No. 1216432-56-2. Pack Sizes: 1mg. Molecular Formula: C??H??D?ClN?O?S, Molecular Weight: 437.97. US Biological Life Sciences.
Hydroxychloroquine N-Oxide is a derivative of Chloroquine (C379965), a standard anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labelling of MRP by quinoline-based photoactive drug IAAQ. Group: Biochemicals. Grades: Highly Purified. CAS No. 1449223-88-4. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C18H26ClN3O2. US Biological Life Sciences.
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Hydroxychloroquine O-Acetate
Quensyl-1-acetate is an analog of Hydroxychloroquine Sulfate, an antimalarial; antirheumatic; lupus erythematosus suppressant. Synonyms: 2-[[4-[ (7-Chloro-4-quinolinyl) amino]pentyl]ethylamino]ethanol 1-Acetate; 2-((4-((7-Chloroquinolin-4-yl)amino)pentyl)(ethyl)amino)ethyl Acetate. Grades: > 95%. CAS No. 47493-14-1. Molecular formula: C20H28ClN3O2. Mole weight: 377.92.
Hydroxychloroquine O-Sulfate
Hydroxychloroquine O-Sulfate is an analogue and potential metabolite of the antimalarial drug Hydroxychloroquine. Studies suggest that there is increased uptake and retention of Hydroxychloroquine O-Sulfate in blood of rheumatoid arthritis subjects. Synonyms: 2-[[4-[ (7-Chloro-4-quinolinyl) amino]pentyl]ethylamino]ethanol 1-(Hydrogen Sulfate) ; 2-[[4-[ (7-Chloro-4-quinolyl) amino]pentyl]ethylamino]ethanol Sulfate. Grades: > 95%. CAS No. 103152-84-7. Molecular formula: C18H26ClN3O4S. Mole weight: 415.94.
5g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C18H28ClN3O5S. CAS No. 747-36-4. Prepack ID 90027084-5g. Molecular Weight 433.95. See USA prepack pricing.
Hydroxychloroquine sulfate
Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 ( TLR7/9 ) signaling. Hydroxychloroquine sulfate is efficiently inhibits SARS-CoV-2 infection in vitro [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HCQ sulfate. CAS No. 747-36-4. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg. Product ID: HY-B1370.
Hydroxychloroquine sulfate
Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine sulfate is efficiently inhibits SARS-CoV-2 infection in vitro. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline sulfate. Product Category: Inhibitors. Appearance: White to off-white solid. CAS No. 747-36-4. Molecular formula: C18H28ClN3O5S. Mole weight: 433.95. Purity: 0.98. IUPACName: 2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol;sulfuric acid. Canonical SMILES: CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO.OS(=O)(=O)O. Product ID: ACM747364-1. Alfa Chemistry ISO 9001:2015 Certified.
Hydroxychloroquine Sulfate
Hydroxychloroquine Sulfate is an autophagy inhibitor that induces autophagic cell death. It also inhibits TLR9. Hydroxychloroquine is an antimalarial drug, and in combination with other medications, it can be used in the treatment of some autto-immune diseases. It has been used in emergency of COVID-19. Synonyms: 2-[[4-[ (7-Chloro-4-quinolinyl) amino]pentyl]ethylamino]ethanol sulfate. Grades: > 95%. CAS No. 747-36-4. Molecular formula: C18H28ClN3O5S. Mole weight: 433.95.
Hydroxychloroquine Sulfate
NADPH oxidase inhibitor; autophagy inhibitor; anti-inflammatory. Hydroxychloroquine sulfate has been used: as an inhibitor of autophagy to treat cells for apoptosis assay to study the role of pirarubicin induced autophagy in bladder cancer cell line to evaluate the antiviral mechanism of hydroxychloroquine against DENV-2 (dengue virus-2) infection by immunofluorescence assay to inhibit lysosome fusion with the autophagosome for treating rheumatoid arthritis and systemic lupus erythematosus. as an anti-inflammatory (via TNF), disease-modifying antirheumatic drug (DMARD), and a heme polymerase inhibitor. It is used as a malaria treatment. Group: Biochemicals. Alternative Names: 2- [ [4- [ (7-Chloro-4-quinolinyl) amino] pentyl] ethylamino] ethanol; 7-Chloro-4- [4- (N-ethyl-N-b-hydroxyethylamino) -1-methylbutylamino] quinoline sulfate, Hydroxycloroquine sulfate; Ercoquin; Plaquenil Sulfate; Quensyl. Grades: Highly Purified. CAS No. 747-36-4. Pack Sizes: 10g, 25g, 50g, 100g. Molecular Formula: C??H??ClN?O?S. US Biological Life Sciences.
Hydroxychloroquine sulfate EP impurity B. Uses: For analytical and research use. Group: Impurity standards. CAS No. 103152-84-7. Molecular formula: C18H26ClN3O4S. Mole weight: 415.93. Catalog: APB103152847.
Hydroxychloroquine sulfate EP impurity E
Hydroxychloroquine sulfate EP impurity E. Uses: For analytical and research use. Group: Impurity standards. CAS No. 10500-64-8. Molecular formula: C14H17ClN2O. Mole weight: 264.75. Catalog: APB10500648.
Hydroxychloroquine (sulfate) (Standard)
Hydroxychloroquine (sulfate) (Standard) is the analytical standard of Hydroxychloroquine (sulfate). This product is intended for research and analytical applications. Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 ( TLR7/9 ) signaling. Hydroxychloroquine sulfate is efficiently inhibits SARS-CoV-2 infection in vitro [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HCQ (sulfate) (Standard). CAS No. 747-36-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1370R.
Hydroxychloroquine Sulfate, USP
NADPH oxidase inhibitor; autophagy inhibitor; anti-inflammatory. Hydroxychloroquine sulfate has been used: as an inhibitor of autophagy to treat cells for apoptosis assay to study the role of pirarubicin induced autophagy in bladder cancer cell line to evaluate the antiviral mechanism of hydroxychloroquine against DENV-2 (dengue virus-2) infection by immunofluorescence assay to inhibit lysosome fusion with the autophagosome for treating rheumatoid arthritis and systemic lupus erythematosus. as an anti-inflammatory (via TNF), disease-modifying antirheumatic drug (DMARD), and a heme polymerase inhibitor. It is used as a malaria treatment. Group: Biochemicals. Alternative Names: 2- [ [4- [ (7-Chloro-4-quinolinyl) amino] pentyl] ethylamino] ethanol; 7-Chloro-4- [4- (N-ethyl-N-b-hydroxyethylamino) -1-methylbutylamino] quinoline sulfate, Hydroxycloroquine sulfate; Ercoquin; Plaquenil Sulfate; Quensyl. Grades: USP. CAS No. 747-36-4. Pack Sizes: 10g, 25g, 50g, 100g, 250g, 500g. Molecular Formula: C??H??ClN?O?S. US Biological Life Sciences.
2- (4- ( (7-Chloroquinolin-4-yl) amino) pentyl) isoindoline-1, 3-dione is an intermediate in the synthesis of Cletoquine (C573505). Cletoquine is a metabolite of Hydroxychloroquine (H916900), an anti-malarial; anti-rheumatic; lupus erythematosus suppressant. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C22H20ClN3O2, Molecular Weight: 393.87. US Biological Life Sciences.
Worldwide
Cletoquine
Cletoquine is a metabolite of Hydroxychloroquine, which is an antimalarial. Synonyms: 2-[[4-[(7-Chloro-4-quinolyl)amino]pentyl]amino]ethanol; (±)-Desethylhydroxychloroquine; Desethyl Hydroxy Chloroquine. Grades: >95%. CAS No. 4298-15-1. Molecular formula: C16H22ClN3O. Mole weight: 307.83.
Cletoquine oxalate
Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine oxalate is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine oxalate is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine oxalate has antimalarial effects and has the potential for autoimmune diseases treatment. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-[[4-[(7-Chloro-4-quinolinyl)amino]pentyl]amino]ethanol Oxalate; (+/-)-Desethylhydroxychloroquine Oxalate. Product Category: Inhibitors. Appearance: Brown Solid. CAS No. 14142-64-4. Molecular formula: C18H24ClN3O5. Mole weight: 397.85. Purity: 0.96. IUPACName: 2-[4-[(7-chloroquinolin-4-yl)amino]pentylamino]ethanol;oxalic acid. Canonical SMILES: CC(CCCNCCO)NC1=C2C=CC(=CC2=NC=C1)Cl.C(=O)(C(=O)O)O. Product ID: ACM14142644. Alfa Chemistry ISO 9001:2015 Certified.
Cletoquine Oxalate
A metabolite of Hydroxychloroquine. Group: Biochemicals. Alternative Names: 2- [ [4- [ (7-Chloro-4-quinolinyl) amino] pentyl] amino] ethanol Oxalate; ( + / -) -Desethyl hydroxychloroquine Oxalate. Grades: Highly Purified. CAS No. 14142-64-4. Pack Sizes: 1mg. US Biological Life Sciences.
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DC661
DC661 is an effective palmitoyl-protein thioesterase 1 (PPT1) inhibitor that inhibits autophagy and ACTS as an antilysosomal agent. Compared with hydroxychloroquine (HCQ), DC661 has significant acid hydrolysis and autophagy inhibition. Synonyms: DC661; 1872387-43-3; N-(7-chloroquinolin-4-yl)-N'-[6-[(7-chloroquinolin-4-yl)amino]hexyl]-N'-methylhexane-1,6-diamine; N1-(7-chloroquinolin-4-yl)-N6-(6-((7-chloroquinolin-4-yl)amino)hexyl)-N6-methylhexane-1,6-diamine; dc-661; C31H39Cl2N5; CHEMBL4873725; SCHEMBL19399303; BCP30743; EX-A2963; XZC38743; s8808; ZB1540; AKOS037649041; DC-661; DC 661; AC-35596; BS-16368; HY-111621; CS-0088759; D80814; 7-chloro-N-[6- ({6-[ (7-chloroquinolin-4-yl)amino]hexyl} (methyl)amino)hexyl]quinolin-4-amine. CAS No. 1872387-43-3. Molecular formula: C31H39Cl2N5. Mole weight: 552.58.
N-Didestethyl Chloroquine-d4 Phthalimide
N-Didestethyl Chloroquine-d4 Phthalimide is an intermediate in the synthesis of Hydroxychloroquine-d4 Sulfate, which is an antimalarial; antirheumatic; lupus erythematosus suppressant. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 2.5mg. Molecular Formula: C22H16D4ClN3O2. US Biological Life Sciences.
Worldwide
ROC-325
ROC-325 is a lysosomal-mediated autophagy inhibitor. It exhibits superior preclinical anticancer activity compared with hydroxychloroquine (HCQ). Uses: Antineoplastic agents. Synonyms: ROC 325; ROC325; 1-[2-[2-[(7-chloroquinolin-4-yl)amino]ethyl-methylamino]ethylamino]-4-methylthioxanthen-9-one. CAS No. 1859141-26-6. Molecular formula: C28H27ClN4OS. Mole weight: 503.06.
(S)-(+)-Hydroxy chloroquine diphosphate
(S)-(+)-Hydroxy chloroquine diphosphate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (S)-2-[[4-[(7-Chloro-4-quinolinyl)amino]pentyl]ethylamino]ethanol Phosphate. Product Category: Heterocyclic Organic Compound. CAS No. 158749-76-9. Molecular formula: C18H32ClN3O9P2. Mole weight: 531.86. Purity: 0.96. IUPACName: 2-[[(4S)-4-[(7-chloroquinolin-4-yl)amino]pentyl]-ethylamino]ethanol. Canonical SMILES: CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO. Product ID: ACM158749769. Alfa Chemistry ISO 9001:2015 Certified. Categories: (S)-Hydroxychloroquine.
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