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| Product | Description | |
|---|---|---|
| Hydroxyurea | 100g Pack Size. Group: Bioactive Small Molecules, Organics. Formula: CH4N2O2. CAS No. 127-07-1. Prepack ID 10872383-100g. Molecular Weight 76.06. See USA prepack pricing. |  |
| Hydroxyurea | 1g Pack Size. Group: Bioactive Small Molecules, Organics. Formula: CH4N2O2. CAS No. 127-07-1. Prepack ID 10872383-1g. Molecular Weight 76.06. See USA prepack pricing. | |
| Hydroxyurea | 25g Pack Size. Group: Bioactive Small Molecules, Organics. Formula: CH4N2O2. CAS No. 127-07-1. Prepack ID 10872383-25g. Molecular Weight 76.06. See USA prepack pricing. | |
| Hydroxyurea | Hydroxyurea is a cell apoptosis inducer that inhibit DNA synthesis through inhibition of ribonucleotide reductase. Hydroxyurea shows anti-orthopoxvirus activity. Group: Inhibitors. CAS No. 127-07-1. Purity: ≥98.0%. Catalog: ACM127071. |  |
| Hydroxyurea | Hydroxyurea is a cell apoptosis inducer that inhibit DNA synthesis through inhibition of ribonucleotide reductase. Hydroxyurea shows anti-orthopoxvirus activity. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Hydroxycarbamide. CAS No. 127-07-1. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-B0313. |  |
| Hydroxyurea | Hydroxyurea is used as an inhibitor of DNA synthesis. As an anti-neoplastic, hydroxyurea inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide. Group: Biochemicals. Alternative Names: Carbamohydroxamic acid; N-Carbamoyl hydroxylamine; N-Hydroxyurea; Biosupressin; Carbamohydroxamic Acid; Carbamoyl Oxime; Cytodrox; Droxia; HU; Hidrix; Hydrea; Hydreia; Hydroxycarbamide; Hydroxycarbamine; N- (Aminocarbonyl) hydroxylamine; Hydroxylurea; Hydura; Hydurea; Litaler; Litalir; N-Carbamoyl hydroxylamine; NCI C04831; NSC 32065; Oxyurea; SK 22591; SQ 1089. Grades: Molecular Biology Grade. CAS No. 127-07-1. Pack Sizes: 10g, 25g, 100g, 250g, 500g. Molecular Formula: CH4N2O2, Molecular Weight: 76.06. US Biological Life Sciences. |  Worldwide |
| N-Hydroxyurea | Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. Uses: Antineoplastic agents; antisickling agents; enzyme inhibitors; nucleic acid synthesis inhibitors. Synonyms: NSC-32065; Hydroxycarbamide; Hydrea; 1-Hydroxyurea; Oxyurea; Biosupressin; Carbamohydroxamic acid; Litalir; N-Carbamoylhydroxylamine; Droxia; Siklos; Carbamoyl Oxime; Cytodrox; Hidrix. Grades: >98%. CAS No. 127-07-1. Molecular formula: CH4N2O2. Mole weight: 76.05. |  |
| Zileuton (N-(1-Benzo[b]thien-2-yl-ethyl)-N-hydroxyurea,. A-64077, Abbott 64077, Leutrol, Zyflo) | An inhibitor of 5-lipoxygenase, the initial enzyme in the biosynthesis of leukotrienes from Arachidonic Acid. Used as an antiasthmatic. Group: Biochemicals. Alternative Names: N-(1-Benzo[b]thien-2-yl-ethyl)-N-hydroxyurea;A-64077; Abbott 64077; Leutrol; Zyflo. Grades: Highly Purified. CAS No. 111406-87-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 3,4-Dichlorophenyl hydroxy urea | Heterocyclic Organic Compound. Alternative Names: 3,4-DICHLOROPHENYL HYDROXY UREA, Urea,(dichlorophenyl)hydroxy-, 128523-56-8, ACMC-1C67A, CTK4B5976, AG-D-58725, S712. CAS No. 128523-56-8. Molecular formula: C7H6Cl2N2O2. Mole weight: 221.040740 [g/mol]. Purity: 0.96. IUPACName: 1-(3,4-dichlorophenyl)-1-hydroxyurea. Canonical SMILES: C1=CC(=C(C=C1N(C(=O)N)O)Cl)Cl. Catalog: ACM128523568. | |
| ABT-515 | ABT-515 is a formidable and discriminative antagonist exhibiting its capability by selectively inhibiting particular enzymes crucial in the advancement of malignant neoplasms. Synonyms: 1-[(2R)-4-[5-[(4-fluorophenyl)-hydroxymethyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxyurea; ABT-515; 189328-52-7; ABT-515; UNII-186W5U73P9; ABT 515; ABT515. Grades: >98%. CAS No. 189328-52-7. Molecular formula: C16H15FN2O3S. Mole weight: 334.37. | |
| allophanate hydrolase | Along with EC 3.5.2.15 (cyanuric acid amidohydrolase) and EC 3.5.1.84 (biuret amidohydrolase), this enzyme forms part of thecyanuric-acid metabolism pathway, which degrades s-triazide herbicides, such as atrazine [2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine], in bacteria. The yeast enzyme (but not that from green algae) also catalyses the reaction of EC 6.3.4.6, urea carboxylase, thus bringing about the hydrolysis of urea to CO2 and NH3 in the presence of ATP and bicarbonate. The enzyme from Pseudomonas sp. strain ADP has a narrow substrate specificity, being unable to use the structurally analogous compounds urea, hydroxyurea or methylcarbamate as substrate. Group: Enzymes. Synonyms: allophanate lyase; AtzF; TrzF. Enzyme Commission Number: EC 3.5.1.54. CAS No. 9076-72-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4443; allophanate hydrolase; EC 3.5.1.54; 9076-72-6; allophanate lyase; AtzF; TrzF. Cat No: EXWM-4443. |  |
| ATR/CDK Inhibitor, NU6027 (2,6-diamino-4-cyclohexyl-methyloxy-5-nitroso-pyrimidine, ATR Inhibitor, NU6027, CDK2 Inhibitor) | A cell-permeable, pyrimidine derivative that acts as an ATP-competitive CDK Inhibitor (Ki=2.5uM for CDK1, and Ki=1.3uM for CDK2), and demonstrates cytostatic properties among a panel of 57 cancer cell lines. Also inhibits ATR kinase (IC50=6.7uM in MCF7 cells), but does not interfere with irradiation-induced autophosphorylation of DNA-PK or ATM. Potentiates a range of DNA-damaging cytotoxic drugs such as hydroxyurea (1.8-fold) and cisplatin (1.4-fold) at 10uM, but not the anti-mitotic paclitaxel. Attenuates G2/M arrest following DNA damage and inhibits RAD51 focus formation. Shown to be synthetically lethal when DNA single-strand break repair is impaired in PARP-inhibited cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 220036-08-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Atreleuton | Atreleuton, a kind of urea compound, has been found to be a 5-lipoxygenase inhibitor as well as Leukotriene B4 receptor antagonist that could probably be useful in study of sorts of diseases like asthma and acute coronary syndromes. It has already been discontinued by VIA Pharmaceuticals. Uses: Lipoxygenase inhibitors. Synonyms: Atreleuton; ABT-761; ABT 761; VIA 2291; VIA-2291; VIA2291; A-85761; Abbott-85761; Atreleuton [USAN]; UNII-U301T88E1M; ABT 761; 1-[(2R)-4-[5-[(4-fluorophenyl)methyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxyurea. Grades: 98%. CAS No. 154355-76-7. Molecular formula: C16H15FN2O2S. Mole weight: 318.37. | |
| ATR Kinase Inhibitor II (3-Amino-6-(4-((1-(dimethylamino)propan-2-yl)sulfonyl)-phenyl)-N-phenylpyrazine-2-carboxamide) | A cell-permeable aminopyrazinyl-sulfone compound that acts as a potent, reversible and ATP-competitive inhibitor of ATR kinase (IC50 = 12nM; Ki=6nM) with excellent selectivity over ATM, DNA-PK (IC50 > 8uM) and in a 50-kinase panel (% inhibition at 2uM = 59, 57, 55, 52, 43 and 42 for AMPK, Lck, RIPK2, Ret, IKK-alpha and FGFR3, respectively). Shown to block pH2AX-Ser139 (IC50 = 420nM in hydroxyurea treated HT29 cells) and preferentially enhance cisplatin cytotoxicity against tumor cells over normal cells by ~7-fold at 620nM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. | Worldwide |
| BAY-1895344 hydrochloride | BAY-1895344 is a potent, orally available and highly selective ATR inhibitor (IC50= 7 nM), which potently inhibits proliferation of a broad spectrum of human tumor cell lines (median IC50 = 78 nM). In cellular mechanistic assays BAY 1895344 potently inhibited hydroxyurea-induced H2AX phosphorylation (IC50 = 36 nM). Synonyms: Elimusertib hydrochloride; BAY 1895344 hydrochloride; BAY1895344 hydrochloride; 2-[(3R)-3-Methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-3-yl)-1,7-naphthyridine hydrochloride; 2-[(3R)-3-methylmorpholin-4-yl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine hydrochloride; Bay 1895344; 1,7-Naphthyridine, 2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-3-yl)-, hydrochloride (1:1). Grades: ≥95%. Molecular formula: C20H22ClN7O. Mole weight: 411.89. | |
| BW-B 70C | BW B70C is a potent and selective inhibitor of 5-lipoxygenase (5-LO). 5-LO is an enzyme that transforms essential fatty acids (EFAs) into leukotrienes and is activated by 5-lipoxygenase activating protein (FLAP). BW-B 70C had high potency and long duration in vivo and was considered as potential anti-asthma drug. It was reported that BW B70C blocks leukotriene C4 synthesis by alveolar macrophages, which decreases the migration for leukocyte to the airway lumen. BW B70C didn't affect vascular leucocyte margination and the blood levels of secreted phospholipase A2 and TNF-&alpha. Synonyms: N-[3-[3-(-Fluorophenoxy)phenyl]-1-methyl-2-propenyl]-N-hydroxyurea. Grades: ≥98%. CAS No. 134470-38-5. Molecular formula: C17H17FN2O3. Mole weight: 316.33. | |
| CMI-977 | CMI-977, an oxolan compound, has been found to be a 5-Lipoxygenases inhibitor and was once studied as an antiasthmatic agent. Synonyms: CMI-977; CMI 977; CMI977; LPD-977; LPD 977; LPD977; MLN-977; MLN977; MLN 977; 1-[4-[(2S,5S)-5-[(4-fluorophenoxy)methyl]oxolan-2-yl]but-3-ynyl]-1-hydroxyurea. Grades: 98%. CAS No. 175212-04-1. Molecular formula: C16H19FN2O4. Mole weight: 322.34. | |
| COX/5-LO-IN-1 | A dual inhibitor of cylooxygenase and 5-lipoxygenase. Synonyms: Urea, N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl-2-propyn-1-yl]-N-hydroxy-; 1-[4-[5-[(4-fluorophenyl)methyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxyurea. CAS No. 154355-75-6. Molecular formula: C16H15FN2O2S. Mole weight: 318.37. | |
| Hydroxy Urea-13C,15N2 | Labeled Hydroxyurea. An anti-neoplastic - inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide. Group: Biochemicals. Alternative Names: N-Hydroxyurea-13C,15N2; Biosupressin-13C,15N2; Carbamohydroxamic Acid-13C,15N2; Carbamoyl Oxime-13C,15N2; Cytodrox-13C,15N2; Droxia-13C,15N2; Hydrea-13C,15N2; Hydreia-13C,15N2; Hydroxycarbamide-13C,15N2; Hydroxycarbamine-13C,15N2; N- (Aminocarbonyl) hydroxylamine-13C, 15N2; Hydroxylurea-13C,15N2; Hydura-13C,15N2; Litaler-13C,15N2; N-Carbamoylhydroxylamine-13C,15N2; NSC 32065-13C,15N2; Oxyurea-13C,15N2; SK 22591-13C,15N2; SQ 1089-13C,15N2. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Ichthammol | Antimicrobial agent. Group: Non-ionic surfactants. Alternative Names: Ichthammonium. CAS No. 8029-68-3. IUPACName: hydroxyurea. Canonical SMILES: C(=O)(N)NO. Catalog: ACM8029683. | |
| N-Hydroxy-2-phenyl-1-hydrazinecarboxamide | Heterocyclic Organic Compound. Alternative Names: MolPort-003-355-384, ZINC00169306, CID2763972, 4W-0270, 121933-76-4. CAS No. 121933-76-4. Molecular formula: C7H9N3O2. Mole weight: 167.17. Purity: 0.96. IUPACName: 1-anilino-3-hydroxyurea. Canonical SMILES: C1=CC=C(C=C1)NNC(=O)NO. Density: 1.379g/cm³. Catalog: ACM121933764. | |
| NU6027 | NU6027 is a potent inhibitor of cellular ATR activity (IC(50)=6.7 μM) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner. NU6027 attenuated G2/M arrest following DNA damage, inhibited RAD51 focus formation and increased the cytotoxicity of the major classes of DNA-damaging anticancer cytotoxic therapy but not the antimitotic, paclitaxel. In A2780 cells sensitisation to cisplatin was greatest in cells with functional p53 and mismatch repair (MMR) and sensitisation to temozolomide was greatest in p53 mutant cells with functional MMR. Importantly, NU6027 was synthetically lethal when DNA single-strand break repair is impaired either through poly(ADP-ribose) polymerase (PARP) inhibition or defects in XRCC1. NU6027 inhibits ATR, impairing G2/M arrest and homologous recombination thus increasing sensitivity to DNA-damaging agents and PARP inhibitors. It provides proof of concept data for clinical development of ATR inhibitors. Synonyms: NU-6027; NU 6027; 2,6-Diamino-4-(cyclohexylmethoxy)-5-nitrosopyrimidine; 6-(Cyclohexylmethoxy)-5-nitroso-2,4-pyrimidinediamine; 4-Cyclohexylmethoxy-2,6-diamino-5-nitrosopyrimidine; 4-Cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine. Grades: ≥98%. CAS No. 220036-08-8. Molecular formula: C11H17N5O2. Mole weight: 251.29. | |
| SCH900776 S-isomer | SCH900776 S-isomer is the S-isomer form of SCH900776, which is a potent, selective and orally bioavailable inhibitor of checkpoint kinase Chk1. It can be used as a protein kinase inhibitor useful in the treatment of protein kinase-mediated diseases. It enhances the γ-H2AX response of hydroxyurea, 5-fluoruracil, and cytarabine. It suppresses accumulation of the Chk1 pS296 autophosphorylation in a dose-dependent manner. Uses: Sch900776 s-isomer can be used as a protein kinase inhibitor useful in the treatment of protein kinase-mediated diseases. Synonyms: SCH900776 S-isomer; SCH 900776 S-isomer; SCH-900776 S-isomer; (S)-6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-A]pyrimidin-7-amine;6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-((3S)-piperidin-3-yl)pyrazolo(1,5-a)pyrimidin-7-amine;SCH-900776 S-isomer. Grades: >98%. CAS No. 891494-64-7. Molecular formula: C15H18BrN7. Mole weight: 376.25. | |
| Zileuton-d4 | Zileuton-d4 is the deuterium labeled Zileuton. Zileuton (A 64077) is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties. Group: Inhibitors. Alternative Names: N-(1-Benzo[b]thien-2-yl-ethyl)-N-hydroxyurea-d4; A-64077-d4; Abbott 64077-d4; Leutrol-d4; Zyflo-d4. CAS No. 1189878-76-9. Molecular formula: C11H8D4N2O2S. Mole weight: 240.31. Appearance: White Solid. Purity: 0.96. IUPACName: 1-[1-(1-benzothiophen-2-yl)-1,2,2,2-tetradeuterioethyl]-1-hydroxyurea. Canonical SMILES: CC(C1=CC2=CC=CC=C2S1)N(C(=O)N)O. Catalog: ACM1189878769. | |
| Zileuton-d4 (major) | An inhibitor of 5-lipoxygenase, the initial enzyme in the biosynthesis of leukotrienes from Arachidonic Acid. Used as an antiasthmatic. Group: Biochemicals. Alternative Names: N-(1-Benzo[b]thien-2-yl-ethyl)-N-hydroxyurea-d4;A-64077-d4; Abbott 64077-d4; Leutrol-d4; Zyflo-d4. Grades: Highly Purified. CAS No. 1189878-76-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
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