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| Product | Description | |
|---|---|---|
| IMIDAZO[1,2-B]PYRIDAZINE | IMIDAZO[1,2-B]PYRIDAZINE. Group: Biochemicals. Grades: Highly Purified. CAS No. 146233-39-8. Pack Sizes: 1g, 2g, 5g. US Biological Life Sciences. |  Worldwide |
| Imidazo[1,2-b]pyridazine-2-carboxylic acid | Imidazo[1,2-b]pyridazine-2-carboxylic acid. Group: Biochemicals. Grades: Highly Purified. CAS No. 160911-42-2. Pack Sizes: 250mg, 500mg, 1g, 2g. US Biological Life Sciences. | Worldwide |
| Imidazo[1,2-b]pyridazine-2-carboxylic acid ≥95% (HPLC) | Imidazo[1,2-b]pyridazine-2-carboxylic acid ≥95% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 250mg, 1g. US Biological Life Sciences. | Worldwide |
| Imidazo[1,2-b]pyridazine 99.5+% | Imidazo[1,2-b]pyridazine 99.5+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g, 100g, 250g. US Biological Life Sciences. | Worldwide |
| 2,6-Dichloroimidazo[1,2-b]pyridazine | 2,6-Dichloroimidazo[1,2-b]pyridazine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2,6-Dichloroimidazo[1,2-b]pyridazine, 112581-77-8, Imidazo[1,2-b]pyridazine,2,6-dichloro-, ACMC-1C7QC, AGN-PC-001DII, CTK4A7881, MolPort-019-918-527, ANW-51942, AKOS006309964, AG-D-31903, RP24771, AK-27688, BR-27688, Imidazo[1,2-b]pyridazine, 2,6-dichloro-, KB-226136, X9018. Product Category: Heterocyclic Organic Compound. CAS No. 112581-77-8. Molecular formula: C6H3Cl2N3. Mole weight: 188.014120 [g/mol]. Purity: 0.96. IUPACName: 2,6-dichloroimidazo[1,2-b]pyridazine. Canonical SMILES: C1=CC(=NN2C1=NC(=C2)Cl)Cl. Density: 1.69g/cm³. Product ID: ACM112581778. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 3,6-Dichloro-2-(2-thienyl)-imidazo[1,2-b]pyridazine | 3,6-Dichloro-2-(2-thienyl)-imidazo[1,2-b]pyridazine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Imidazo[1,2-b]pyridazine, 3,6-dichloro-2-(2-thienyl)-;3,6-Dichloro-2-(2-thienyl)imidazo[1,2-b]pyridazine. Product Category: Heterocyclic Organic Compound. CAS No. 483367-56-2. Molecular formula: C10H5Cl2N3S. Mole weight: 270.14. Product ID: ACM483367562. Alfa Chemistry ISO 9001:2015 Certified. | |
| 6-chloro-2-Methyl-3-broMo-iMidazo[1,2-b]pyridazine | 6-chloro-2-Methyl-3-broMo-iMidazo[1,2-b]pyridazine. Uses: Designed for use in research and industrial production. Product Category: Imidazoles. Appearance: Solid. CAS No. 18112-31-7. Molecular formula: C7H5BrClN3. Mole weight: 246.49. Purity: 0.98. Product ID: ACM18112317. Alfa Chemistry ISO 9001:2015 Certified. Categories: 3-Bromo-6-chloro-2-methylimidazo[1,2-b]pyridazine. | |
| 6-chloro-2-Methyl-3-broMo-iMidazo[1,2-b]pyridazine.1broMine | 6-chloro-2-Methyl-3-broMo-iMidazo[1,2-b]pyridazine.1broMine. Uses: Designed for use in research and industrial production. Product Category: Imidazoles. Appearance: solid. CAS No. 78867-38-6. Molecular formula: C7H6Br2ClN3. Mole weight: 327.4. Purity: 0.95. Product ID: ACM78867386. Alfa Chemistry ISO 9001:2015 Certified. | |
| 6-Chloro-2-methylimidazo[1,2-b]pyridazine | 6-Chloro-2-methylimidazo[1,2-b]pyridazine. Uses: Designed for use in research and industrial production. Product Category: Imidazoles. Appearance: Light brown powder. CAS No. 14793-00-1. Molecular formula: C7H6ClN3. Mole weight: 167.6. Purity: 0.95. Product ID: ACM14793001. Alfa Chemistry ISO 9001:2015 Certified. | |
| 6-Chloro-2-methylimidazo[1,2-b]pyridazine-3-carboxylic acid | 6-Chloro-2-methylimidazo[1,2-b]pyridazine-3-carboxylic acid. Uses: Designed for use in research and industrial production. Product Category: Imidazoles. Appearance: White to off-white powder. CAS No. 14714-22-8. Molecular formula: C8H6ClN3O2. Mole weight: 211.61. Purity: 0.98. Product ID: ACM14714228. Alfa Chemistry ISO 9001:2015 Certified. | |
| 6-Chloro-2-methylimidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester | 6-Chloro-2-methylimidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester. Uses: Designed for use in research and industrial production. Product Category: Imidazoles. Appearance: Solid. CAS No. 14714-18-2. Molecular formula: C10H10ClN3O2. Mole weight: 239.66. Purity: 0.97. Product ID: ACM14714182. Alfa Chemistry ISO 9001:2015 Certified. | |
| 6-Chloro-imidazo[1,2-b]pyridazine | 6-Chloro-imidazo[1,2-b]pyridazine. Group: Biochemicals. Grades: Highly Purified. CAS No. 6775-78-6. Pack Sizes: 10g, 25g, 50g, 100g, 250g. Molecular Formula: C6H4ClN3. US Biological Life Sciences. | Worldwide |
| 6-Chloro-imidazo[1,2-b]pyridazine-2-acetic acid methyl ester | 6-Chloro-imidazo[1,2-b]pyridazine-2-acetic acid methyl ester. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 215531-00-3, CTK4E7118, AG-E-57954, PB32916, METHYL 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-2-ACETATE, Imidazo[1,2-b]pyridazine-2-aceticacid, 6-chloro-, methyl ester, 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-2-ACETIC ACID METHYL ESTER, 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-2-ACETIC ACID, METHYL ESTER. Product Category: Heterocyclic Organic Compound. CAS No. 215531-00-3. Molecular formula: C9H8ClN3O2. Mole weight: 225.631720 [g/mol]. Purity: 0.96. IUPACName: methyl 2-(6-chloroimidazo[1,2-b]pyridazin-2-yl)acetate. Product ID: ACM215531003. Alfa Chemistry ISO 9001:2015 Certified. | |
| 6-Chloroimidazo[1,2-b]pyridazine-3-carbaldehyde | 6-Chloroimidazo[1,2-b]pyridazine-3-carbaldehyde. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 154578-26-4, 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-3-CARBALDEHYDE, 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-3-CARBOXALDEHYDE, IMIDAZO[1,2-B]PYRIDAZINE-3-CARBOXALDEHYDE, 6-CHLORO-, AGN-PC-009A7T, CTK4C8330, RW3142, AKOS006309726, AG-E-02563, PB17781, QC-2347, AK-82376, KB-73929, AB1000282, 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-3-carbaldehyde, I14-17533, Imidazo[1,2-b]pyridazine-3-carboxaldehyde,6-chloro-. Product Category: Heterocyclic Organic Compound. CAS No. 154578-26-4. Molecular formula: C7H4ClN3O. Mole weight: 181.579160 [g/mol]. Purity: 0.96. IUPACName: 6-chloroimidazo[1,2-b]pyridazine-3-carbaldehyde. Density: 1.579g/cm³. Product ID: ACM154578264. Alfa Chemistry ISO 9001:2015 Certified. | |
| 6-(Dimethylamino)imidazo[1,2-b]pyridazine-2-carbaldehyde | 6-(Dimethylamino)imidazo[1,2-b]pyridazine-2-carbaldehyde. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 6-(dimethylamino)imidazo[1,2-b]pyridazine-2-carbaldehyde, 1184918-55-5, SBB069404, ZINC33359450, AKOS015918698, KB-198867, FT-0659649, A804004, S14-0549, 6-(dimethylamino)-2-imidazo[1,2-b]pyridazinecarboxaldehyde. Product Category: Heterocyclic Organic Compound. CAS No. 1184918-55-5. Molecular formula: C9H10N4O. Mole weight: 190.201900 [g/mol]. Purity: 0.96. IUPACName: 6-(dimethylamino)imidazo[1,2-b]pyridazine-2-carbaldehyde. Canonical SMILES: CN(C)C1=NN2C=C(N=C2C=C1)C=O. Product ID: ACM1184918555. Alfa Chemistry ISO 9001:2015 Certified. | |
| (2R) -2- (2, 5-Difluorophenyl) pyrrolidine | (2R) -2- (2, 5-Difluorophenyl) pyrrolidine is used in the synthesis of imidazo[1,2-b]pyridazine compounds as inhibitors of Trk kinases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1218935-59-1. Pack Sizes: 50mg, 250mg. Molecular Formula: C10H11F2N, Molecular Weight: 183.2. US Biological Life Sciences. | Worldwide |
| (2S, 3S) -3- hydroxy-1, 2-pyrrolidinedicarboxyl ic acid 1-tert-Butyl 2-Methyl Ester | (2S, 3S) -3- hydroxy-1, 2-pyrrolidinedicarboxyl ic acid 1-tert-butyl 2-methyl ester is a reactant used to improve potency of imidazo[1,2-b]pyridazines as IKK β inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 184046-78-4. Pack Sizes: 25mg, 250mg. Molecular Formula: C11H19NO5, Molecular Weight: 245.27. US Biological Life Sciences. | Worldwide |
| Bamirastine | Bamirastine inhibits the binding of the ligand to the recombinant human histamine H1 receptor (rhH1R) with an IC50 of 17.3 nM. Synonyms: TAK-427; Bamirastina; 2-(6-((3-(4-(Diphenylmethoxy)piperidin-1-yl)propyl)amino)imidazo(1,2-b)pyridazin-2-yl)-2-methylpropanoic acid; Imidazo[1,2-b]pyridazine-2-acetic acid, 6-[[3-[4-(diphenylmethoxy)-1-piperidinyl]propyl]amino]-α,α-dimethyl-. Grade: 95%. CAS No. 215529-47-8. Molecular formula: C31H37N5O3. Mole weight: 527.66. |  |
| GNF-8625 monopyridin-N-piperazine hydrochloride | GNF-8625 monopyridin-N-piperazine hydrochloride is a TRK inhibitor. (Extracted from the patent WO 2020038415 A1). Synonyms: TRKi-2; (R)-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)-3-(6-(piperazin-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazine hydrochloride. CAS No. 2412055-62-8. Molecular formula: C25H27ClFN7. Mole weight: 479.98. | |
| I-191 | I-191 is a potent antagonist of protease activated receptor 2 (PAR2). Synonyms: 4-[8-Tert-Butyl-6-(4-Fluorophenyl)Imidazo[1,2-B]Pyridazine-2-Carbonyl]-3,3-Dimethylpiperazin-2-One; PAR2 Antagonist I-191; SCHEMBL16598387; GTPL10268; BCP32684. Grade: 98%. CAS No. 1690172-25-8. Molecular formula: C23H26FN5O2. Mole weight: 423.5. | |
| (6-(Ethylamino)imidazo[1,2-b]pyridazin-2-yl)methanol | (6-(Ethylamino)imidazo[1,2-b]pyridazin-2-yl)methanol. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1184920-60-2, (6-(ethylamino)imidazo[1,2-b]pyridazin-2-yl)methanol, [6-(ethylamino)imidazo[1,2-b]pyridazin-2-yl]methanol, SBB069401, ZINC33359447, AKOS015918669, KB-146028, FT-0655010, A804034, S14-0546, [6-(ethylamino)-2-imidazo[1,2-b]pyridazinyl]methanol. Product Category: Heterocyclic Organic Compound. CAS No. 1184920-60-2. Molecular formula: C9H12N4O. Mole weight: 192.217780 [g/mol]. Purity: 0.96. IUPACName: [6-(ethylamino)imidazo[1,2-b]pyridazin-2-yl]methanol. Canonical SMILES: CCNC1=NN2C=C(N=C2C=C1)CO. Product ID: ACM1184920602. Alfa Chemistry ISO 9001:2015 Certified. | |
| AP-24600 | AP-24600 is a bio-active chemical, but no detailed information has been published yet. Synonyms: AP-24600; AP 24600; AP24600; DA-12847; KB-310048; DA 12847; KB 310048; DA12847; KB310048; UNII-OZ477A282R; OZ477A282R; 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzoic acid. Grade: 98%. CAS No. 1300690-48-5. Molecular formula: C16H11N3O2. Mole weight: 277.28. | |
| BAY-1217389 | BAY-1217389, an imidazopyridazin derivative, has been found to be a TTK protein inhibitor that could probably be effective as an antineoplastic agent and also be a potentialcell death stimulant. It is still under Phase I trail for solid tumor. Synonyms: BAY1217389; BAY-1217389; BAY 1217389; N-cyclopropyl-4-(6-(2,3-difluoro-4-methoxyphenoxy)-8-((3,3,3-trifluoropropyl)amino)imidazo[1,2-b]pyridazin-3-yl)-2-methylbenzamide. Grade: 98%. CAS No. 1554458-53-5. Molecular formula: C27H24F5N5O3. Mole weight: 561.51. | |
| Cefozopran Dihydrochloride | Antibacterial. Group: Biochemicals. Alternative Names: 1-[[ (6R, 7R) -7-[[2Z) - (5-Amino-1, 2, 4-thiadiazol-3-yl) (methoxyimino) acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4. 2. 0]oct-2-en-3-yl]methyl]imidazo[1, 2-b]pyridazinium Inner Salt Dihydrochloride; SCE-1787 Dihydrochloride; Firstcin Dihydrochloride. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| DDR1-IN-5 | DDR1-IN-5, a selective Discoidin domain receptor 1 (DDR1) inhibitor (IC50 = 7.36 nM), has anticancer activity. It inhibits the autophosphorylation of DDR1b (Y513) with an IC50 of 4.1 nM. Synonyms: 1,2-Benzisoxazol-3-amine, 7-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-6-methyl-N-[5-(trifluoromethyl)-3-pyridinyl]-. Grade: ≥95%. CAS No. 2416022-90-5. Molecular formula: C22H13F3N6O. Mole weight: 434.37. | |
| DDR1-IN-6 | DDR1-IN-6, a selective Discoidin domain receptor 1 (DDR1) inhibitor (IC50 = 9.72 nM), has anticancer activity. It inhibits the autophosphorylation of DDR1b (Y513) with an IC50 of 9.7 nM. Synonyms: 1,2-Benzisoxazol-3-amine, 7-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-6-methyl-N-[3-(trifluoromethyl)phenyl]-. CAS No. 2416021-47-9. Molecular formula: C23H14F3N5O. Mole weight: 433.39. | |
| GNE-8525 | This active molecular is a selective pan-TRK inhibitor. GNE-8525 shows potent antiproliferation activity (IC50 = 0.003 μM) and it shows in vivo antitumor efficacy in tumor xenograft model derived from the KM12 cell line. TRKA are believed to be the key oncogenic driver in many tumors including glioblastoma, melanoma and so on. Uses: Antitumor. Synonyms: GNF-8625; GNF 8625; GNF8625. (R)-1-(6-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-[2,4'-bipyridin]-2'-yl)piperidin-4-ol. Grade: 98%. CAS No. 1196546-33-4. Molecular formula: C31H30FN7O. Mole weight: 535.63. | |
| Haspin Kinase Inhibitor, CHR-6494 (3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine, Haploid Germ Cell-Specific Nuclear Protein Kinase Inhibitor, CHR-6494, Indazolyl-propylimidazopyridazin-amine) | A cell-permeable indazolyl imidazopyridazinamine compound that acts as a potent and reversible inhibitor of histone kinase haspin activity (IC50 = 2nM) with moderate selectivity over TrkA, GSK-3beta, PIM1, Cdk1/B and Cdk2/A (% inhibition at 100nM = 58, 48, 36, 34 and 33, respectively) among a panel of 27-kinases. Shown to block pH3-Thr3, with no effect on pH3-Ser10 and pH3-Ser28, cause mitotic catastrophe, upregulate BUB1 and cyclin B1 levels, and potently induce apoptosis (IC50 = 473, 500 and 752nM in HeLa, HCT-116 and MDA-MB-231 cells, respectively). Further, efficiently blocks bFGF-induced sprouting vessel by 70% at 1uM (chicken embryo aortic arch ring assay) and suppresses tumor growth in HCT-116 xenografted mouse model (50mg/kg, i.p.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| IL-17A inhibitor 1 | IL-17A inhibitor 1 is an inhibitor of IL-17A, with IC50s of <9.45 nM and 9.3 nM in alphalisa assay and HT-29 cells. Synonyms: 1,2,5-Oxadiazole-3-carboxamide, N-[(S)-(4,4-difluorocyclohexyl)[7-[(1S)-2-methoxy-1-[(4S)-2-oxo-4-(trifluoromethyl)-1-imidazolidinyl]ethyl]imidazo[1,2-b]pyridazin-2-yl]methyl]-4-methyl-; N-[(S)-(4,4-Difluorocyclohexyl)(7-{(1S)-2-methoxy-1-[(4S)-2-oxo-4-(trifluoromethyl)-1-imidazolidinyl]ethyl}imidazo[1,2-b]pyridazin-2-yl)methyl]-4-methyl-1,2,5-oxadiazole-3-carboxamide. Grade: ≥95%. CAS No. 2452464-73-0. Molecular formula: C24H27F5N8O4. Mole weight: 586.51. | |
| IL-17A inhibitor 2 | IL-17A inhibitor 2, an IL-17A inhibitor, is used to treat psoriasis, rheumatoid arthritis and multiple sclerosis. Synonyms: 1,2,5-Oxadiazole-3-carboxamide, N-[(S)-(4,4-difluorocyclohexyl)[7-[(1S)-2-methoxy-1-[(4S)-2-oxo-4-(trifluoromethyl)-1-imidazolidinyl]ethyl]imidazo[1,2-b]pyridazin-2-yl]methyl]-4-(difluoromethyl)-; N-((S)-(4,4-difluorocyclohexyl)(7-((S)-2-methoxy-1-((S)-2-oxo-4-(trifluoromethyl)imidazolidin-1-yl)ethyl)imidazo[1,2-b]pyridazin-2-yl)methyl)-4-(difluoromethyl)-1,2,5-oxadiazole-3-carboxamide. CAS No. 2452464-77-4. Molecular formula: C24H25F7N8O4. Mole weight: 622.50. | |
| PIM-Kinase Inhibitor IX, SGI-1776 (N- ( (1-Methylpiperidin-4-yl) methyl) -3- (3- (trifluoromethoxy) phenyl) imidazo[1, 2-b]pyridazin-6-amine, 2H2SO4) | A cell-permeable imidazopyridazine compound that acts as a potent, reversible and ATP-competitive inhibitor of Pim-1,2,3, Flt-3 and haspin kinase activities (IC50=7, 363, 69, 44 and 34nM, respectively) with moderate (40% inhibition at 1uM for c-kit) to excellent selectivity over CDKs, Aurora, Chk1, IKK, JNK, Abl, Raf, PKA, PKC and PI 3-K among 300-kinases. Shown to inhibit RNA synthesis, block phosphorylation of c-Myc-Ser62 and STAT3-Tyr705, and decrease c-Myc and Mcl-1 protein levels; cause cell cycle arrest and induce apoptosis in CLL lymphocytes and in AML cells, and efficiently arrest the growth of several prostate cancer cells (IC50 <10uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O; 2H?SO?, Molecular Weight: 601.6. US Biological Life Sciences. | Worldwide |
| Ponatinib-[d8] | Ponatinib-[d8] is the labelled analogue of Ponatinib, which is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0. 37 nM, 1. 1 nM, 1. 5 nM, 2. 2 nM and 5. 4 nM, respectively. Synonyms: Ponatinib D8; 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl-2,2,3,3,5,5,6,6-d8)methyl]-3-(trifluoromethyl)phenyl]-benzamide. Grade: 95% by HPLC; 95% atom D. CAS No. 1562993-37-6. Molecular formula: C29H19D8F3N6O. Mole weight: 540.61. | |
| Ponatinib, Free Base (AP24534) | Ponatinib is a novel potent, orally available small molecule multitargeted kinase inhibitor. Ponatinib inhibits both native and mutant BCR-ABL. Ponatinib is used in the treatment of chronic myeloid leukemia (CML) with BCR-ABL kinase inhibitors. Ponatinib is the active ingredient in the drug product sold under the trade name Iclusig®, currently approved in at least one country for use in patients with chronic myeloid leukemia (CML) and Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia. Group: Biochemicals. Alternative Names: 3- (2-Imidazo[1, 2-b]pyridazin-3-ylethynyl) -4-methyl-N-[4-[ (4-methyl-1-piperazinyl) methyl]-3- (trifluoromethyl) phenyl]benzamide; AP 24534; Iclusig. Grades: Highly Purified. CAS No. 943319-70-8. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C29H27F3N6O, Molecular Weight: 532.56. US Biological Life Sciences. | Worldwide |
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