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| Product | Description | |
|---|---|---|
| indoleamine 2,3-dioxygenase | A protohemoprotein. Requires ascorbic acid and methylene blue for activity. This enzyme has broader substrate specificity than EC 1.13.11.11, tryptophan 2,3-dioxygenase. It is induced in response to pathological conditions and host-defense mechanisms and its distribution in mammals is not confined to the liver. While the enzyme is more active with D-tryptophan than L-tryptophan, its only known function to date is in the metabolism of L-tryptophan. Superoxide radicals can replace O2 as oxygen donor. Group: Enzymes. Synonyms: IDO (ambiguous); tryptophan pyrrolase (ambiguous); D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing). Enzyme Commission Number: EC 1.13.11.52. CAS No. 9014-51-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0571; indoleamine 2,3-dioxygenase; EC 1.13.11.52; 9014-51-1; IDO (ambiguous); tryptophan pyrrolase (ambiguous); D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing). Cat No: EXWM-0571. |  |
| Indoleamine 2,3-dioxygenase 1 (199-207) | Indoleamine 2,3-dioxygenase 1 (199-207) is amino acids 199 to 207 fragment of Indoleamine 2,3-dioxygenase 1. IDO1 is a member of a unique class of mammalian haem dioxygenases that catalyse the oxidative catabolism of the least-abundant essential amino acid, L-Trp (L-tryptophan), along the kynurenine pathway. Synonyms: IDO1 (199-207). |  |
| 1-Methyl-[d3]-L-tryptophan | 1-Methyl-[d3]-L-tryptophan is a labelled 1-Methyltryptophan. 1-Methyltryptophan is an inhibitor of the tryptophan catabolic enzyme indoleamine 2,3-dioxygenase. Synonyms: 1-Methyl-d3-L-tryptophan. Grade: 95% by HPLC; 98% atom D. CAS No. 1801851-87-5. Molecular formula: C12H11D3N2O2. Mole weight: 221.27. | |
| 1-Methyl-D-tryptophan | 1-Methyl-D-tryptophan is used in biological studies to determine the effect of IDO2 enzyme (indoleamine-(2,3)-dioxygenase) activity and IDO2-mediated arrest of human T cell proliferation. It reverses IDO-mediated immune suppression. Group: Biochemicals. Grades: Highly Purified. CAS No. 110117-83-4. Pack Sizes: 250mg, 500mg. Molecular Formula: C12H14N2O2. US Biological Life Sciences. |  Worldwide |
| 1-Methyl-L-tryptophan | 1-Methyl-L-tryptophan is a competitive inhibitor of indoleamine 2,3-dioxygenase (IDO). Synonyms: L-Abrine; 1-Methyl-L-tryptophan; H-Trp(1-Me)-OH; (S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid; 1-Methyltryptophan; L-Tryptophan, 1-methyl-; UNII-XD0FY1J13B; XD0FY1J13B; (2S)-2-amino-3-(1-methylindol-3-yl)propanoic acid. Grade: ≥ 98% (Chiral HPLC). CAS No. 21339-55-9. Molecular formula: C12H14N2O2. Mole weight: 218.26. | |
| 1-methyl-tryptophan | 1-methyl-tryptophan is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and 1-methyl-tryptophan markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes. Synonyms: 1-Methyl-DL-tryptophan; 1-Methyltryptophan; 2-Amino-3-(1-methyl-1H-indol-3-yl)propanoic acid; N-methyl-DL-tryptophan; DL-1-Methyltryptophan; (Rac)-Indoximod; (Rac)-NLG-8189. Grade: ≥98%. CAS No. 26988-72-7. Molecular formula: C12H14N2O2. Mole weight: 218.25. | |
| 2-(4-Nitrobenzyl)-2-thiopseudourea Hydrochloride | 2-(4-Nitrobenzyl)-2-thiopseudourea Hydrochloride is used in preparation of indoleamine dioxygenase and study SAR of benzylisothiourea derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 4357-96-4. Pack Sizes: 100mg, 250mg. Molecular Formula: C8H9N3O2S; HCl, Molecular Weight: 211.243646. US Biological Life Sciences. | Worldwide |
| 3-(1H-1,2,3-Triazol-4-yl)pyridine | 3-(1H-1,2,3-Triazol-4-yl)pyridine is a reactant used in the synthesis of 4-aryl-1H-1,2,3-triazoles which possesses more Indoleamine 2,3-dioxygenase (IDO) inhibitory potency than the most commonly used 1-methyltryptophan. Group: Biochemicals. Grades: Highly Purified. CAS No. 120241-79-4. Pack Sizes: 100mg, 250mg. Molecular Formula: C7H6N4, Molecular Weight: 146.15. US Biological Life Sciences. | Worldwide |
| 3-TYP | 3-TYP is an inhibitor of SIRT3 (IC50of 38 ?M) and an inhibitor of Methionine Adenosyltransferase (MAT) 2 and Indoleamine 2,3-Dioxygenase (IDO). There may be many off-target sites for 3-TYP that need to be examined, such as NAD-dependent enzymes, including dehydrogenases[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 120241-79-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108331. |  |
| BMS-978587 | BMS-978587 (IDO-IN-4) is an indoleamine 2,3-dioxygenase 1 ( IDO-1 ) inhibitor, extracted from patent WO2014150677A1, Compound example 1 enantiomer 1. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IDO-IN-4. CAS No. 1629125-65-0. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18769. | |
| BMS-986205 | BMS-986205 is a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor. It is undergoing a phase I/II clinical trial for the bladder and cervical cancer therapy in combination with nivolumab, an anti-programmed cell death protein 1 (PD-1) monoclonal antibody. Uses: Drug combination with nivolumab. Synonyms: BMS-986205; BMS 986205; BMS986205; (2R)-N-(4-chlorophenyl)-2-[4-(6-fluoroquinolin-4-yl)cyclohexyl]propanamide. CAS No. 1923833-60-6. Molecular formula: C24H24ClFN2O. Mole weight: 410.917. | |
| BMS-986242 | BMS-986242 is a potent and selective inhibitor of Indoleamine 2,3-dioxygenase 1 (IDO1), a heme-containing dioxygenase enzyme implicated in cancer immune response. BMS-986242 has been developed for the treatment of a variety of cancers including metastatic melanoma and renal cell carcinoma. Synonyms: BMS 986242; BMS986242. Grade: 98% by HPLC. CAS No. 1923844-48-7. Molecular formula: C24H24ClFN2O. Mole weight: 410.9. | |
| Brassinin | Brassinin is an indoleamine-2,3-dioxygenase inhibitor found in cruciferous vegetables. It induces cell cycle arrest and apoptosis in prostate cancer cells and inhibits DMBA-induced skin tumor formation in vivo. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Brassinine; CCG-208623; CCG208623; CCG 208623; HE-005916; HE005916; HE 005916; HE-292778; HE292778; HE292778. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 105748-59-2. Molecular formula: C11H12N2S2. Mole weight: 236.35. Purity: >98%. IUPACName: methyl ((1H-indol-3-yl)methyl)carbamodithioate. Canonical SMILES: S=C(SC)NCC1=CNC2=C1C=CC=C2. Product ID: ACM105748592-1. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Brassinin | Brassinin is an inhibitor of indoleamine 2,3-dioxygenase (IDO; Ki = 28 μM for human IDO) with antifungal and anticancer activities. Brassinin also inhibits IL-6-inducible STAT3 activation and attenuates tumor growth in a xenograft lung cancer mouse model. Brassinin is found in brassicas. Synonyms: Brassinine; CCG-208623; CCG208623; CCG 208623; HE-005916; HE005916; HE 005916; HE-292778; HE292778; HE292778; Methyl (1H-indol-3-ylmethyl)carbamodithioate. Grade: 98%. CAS No. 105748-59-2. Molecular formula: C11H12N2S2. Mole weight: 236.36. | |
| IDO-IN-12 | IDO-IN-12 is an indoleamine 2,3-dioxygenase ( IDO ) inhibitor extracted from patent WO 2017181849 A1. Uses: Scientific research. Group: Signaling pathways. CAS No. 1888341-29-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115122. | |
| IDO-IN-2 | IDO-IN-2 is a potent inhibitor of IDO (indoleamine-(2,3)-dioxygenase) with IC50 of 3 nM. Synonyms: IDO inhibitor 1; 1-[2-[bis(2-methylpropyl)amino]-5-[2-(2H-tetrazol-5-yl)phenyl]phenyl]-3-(4-methylphenyl)urea. CAS No. 1668565-74-9. Molecular formula: C29H35N7O. Mole weight: 497.63. | |
| indole 2,3-dioxygenase | Enzymes from the plants Tecoma stans, Jasminum grandiflorum and Zea mays are flavoproteins containing copper. They are part of enzyme systems that form either anthranil (2,1-benzoisoxazole) (Tecoma stans), anthranilate (Jasminum grandiflorum) or both (Zea mays) as the final product. A second enzyme from Tecoma stans is not a flavoprotein, does not require copper, and is part of a system that forms anthranilate as the final product. Group: Enzymes. Synonyms: indole oxidase; indoleamine 2,3-dioxygenase (ambiguous); indole:O2 oxidoreductase; indole-oxygen 2,3-oxidoreductase (decyclizing); IDO (ambiguous); indole:oxygen 2,3-oxidoreductase (decyclizing). Enzyme Commission Number: EC 1.13.11.17. CAS No. 37256-57-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0536; indole 2,3-dioxygenase; EC 1.13.11.17; 37256-57-8; indole oxidase; indoleamine 2,3-dioxygenase (ambiguous); indole:O2 oxidoreductase; indole-oxygen 2,3-oxidoreductase (decyclizing); IDO (ambiguous); indole:oxygen 2,3-oxidoreductase (decyclizing). Cat No: EXWM-0536. | |
| Indoximod | A methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy. Synonyms: NLG8189; NLG 8189; NLG-8189; D-1MT; 1-methyl-D-tryptophan; H-D-Trp(Me)-OH. Grade: > 98%. CAS No. 110117-83-4. Molecular formula: C12H14N2O2. Mole weight: 218.25. | |
| Indoximod | Indoximod (1-Methyl-D-tryptophan) is an orally active indoleamine 2,3-dioxygenase ( IDO ) pathway inhibitor. Indoximod acts as a Trp mimetic in regulating mTOR. Indoximod is an immunometabolic adjuvant used for the research of cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 1-Methyl-D-tryptophan; NLG-8189. CAS No. 110117-83-4. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-16724. | |
| Linrodostat | Linrodostat (BMS-986205) is a selective and irreversible indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC 50 value of 1.1 nM in IDO1 -HEK293 cells. Linrodostat is well tolerated with potent pharmacodynamic activity in advanced cancers [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-986205; ONO-7701. CAS No. 1923833-60-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101560. | |
| Navoximod | Navoximod (GDC-0919; NLG-?919) is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GDC-0919; NLG-?919. CAS No. 1402837-78-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18770B. | |
| Navoximod free base | Navoximod, also known as IDO-IN-7 and NLG-1488, is an indoleamine 2,3-dioxygenase (IDO) inhibitor. It is also used as an immunomodulator and an antineoplastic. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Navoximod; IDO-IN-7; IDOIN7; IDO IN 7; Navoximod Phosphate; NLG-1488; NLG 1488; NLG1488. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1402837-78-8. Molecular formula: C18H21FN2O2. Mole weight: 316.38. Purity: >98%. IUPACName: (1R,4r)-4-((R)-2-((S)-6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexan-1-ol. Canonical SMILES: O[C@@H]([C@H]1CC[C@H](O)CC1)C[C@@H](C2=C3C=CC=C2F)N4C3=CN=C4. Product ID: ACM1402837788. Alfa Chemistry ISO 9001:2015 Certified. | |
| Necrostatin-1 | Competitive indoleamine 2,3-dioxygenase (IDO) inhibitor. Cell permeable, potent and selective necroptosis (a non-apoptotic form of programmed cell death) inhibitor. Showed neuroprotection in a murine model of ischemic brain injury in vivo. Selective and ATP-competitive receptor-interacting protein kinase 1 (RIPK1) inhibitor. Used in inflammatory and degenerative disease models to target RIPK1. Suppresses autophagy and apoptosis in murine brain injury models. Group: Biochemicals. Alternative Names: Nec-1, MTH-Trp, MTH-DL-Tryptophan, Methyl-thiohydantoin DL-tryptophan, 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone. Grades: Highly Purified. CAS No. 4311-88-0. Pack Sizes: 5mg, 25mg. Molecular Formula: C??H??N?OS. US Biological Life Sciences. | Worldwide |
| Palmatine | Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. Palmatine shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5,6-Dihydro-2,3,9,10-tetramethoxydibenzo[a,g]quinolizinium. Product Category: Inhibitors. Appearance: Powder. CAS No. 3486-67-7. Molecular formula: C21H22NO4. Mole weight: 352.4. Purity: 0.98. IUPACName: 2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium. Canonical SMILES: COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)OC)OC)OC. Product ID: ACM3486677. Alfa Chemistry ISO 9001:2015 Certified. | |
| Palmatine chloride | Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC 50 s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC 50 of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 10605-02-4. Pack Sizes: 10 mM * 1 mL; 250 mg; 1 g. Product ID: HY-N0110. | |
| Palmatine chloride | Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium chloride. Product Category: Inhibitors. Appearance: Powder. CAS No. 10605-02-4. Molecular formula: C21H22ClNO4. Mole weight: 387.86. Purity: 0.98. IUPACName: 2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium;chloride. Canonical SMILES: COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)OC)OC)OC.[Cl-]. Product ID: ACM10605024. Alfa Chemistry ISO 9001:2015 Certified. | |
| Palmatine hydroxide | Palmatine hydroxide is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC 50 s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine hydroxide can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC 50 of 96 μM. Palmatine hydroxide shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 131-04-4. Pack Sizes: 10 mM * 1 mL; 250 mg; 1 g. Product ID: HY-N0110B. | |
| PROTAC IDO1 Degrader-1 | PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to Cereblon E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 ?M). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2488851-89-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131911. | |
| (S)-LY-3381916 | (S)-LY-3381916 ((S)-IDO1-IN-5; Example 1B) is an active S-isomer of LY-3381916. (S)-LY-3381916 binds to IDOL with an IC 50 value less than 1.5 μΜ [1]. LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1 [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (S)-IDO1-IN-5. CAS No. 2166616-76-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111540B. | |
| tryptophan 2,3-dioxygenase | A protohemoprotein. In mammals, the enzyme appears to be located only in the liver. This enzyme, together with EC 1.13.11.52, indoleamine 2,3-dioxygenase, catalyses the first and rate-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism. The enzyme is specific for tryptophan as substrate, but is far more active with L-tryptophan than with D-tryptophan. Group: Enzymes. Synonyms: tryptophan pyrrolase (ambiguous); tryptophanase; tryptophan oxygenase; tryptamine 2,3-dioxygenase; tryptophan peroxidase; indoleamine 2,3-dioxygenase (ambiguous); indolamine 2,3-dioxygenase (ambiguous); L-tryptophan pyrrolase; TDO; L-tryptophan 2,3-dioxygenase; L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing). Enzyme Commission Number: EC 1.13.11.11. CAS No. 9014-51-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0531; tryptophan 2,3-dioxygenase; EC 1.13.11.11; 9014-51-1; tryptophan pyrrolase (ambiguous); tryptophanase; tryptophan oxygenase; tryptamine 2,3-dioxygenase; tryptophan peroxidase; indoleamine 2,3-dioxygenase (ambiguous); indolamine 2,3-dioxygenase (ambiguous); L-tryptophan pyrrolase; TDO; L-tryptophan 2,3-dioxygenase; L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing). Cat No: EXWM-0531. | |
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