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Indoline impurity 1 (Epalrestat impurities) Indoline impurity 1 (Epalrestat impurities). Uses: For analytical and research use. Group: Impurity standards. CAS No. 1408072-62-7. Molecular formula: C19H25NO2. Mole weight: 299.41. Catalog: APB1408072627. Alfa Chemistry Analytical Products 4
Bromfenac Impurity (7-(4-bromobenzoyl)indoline-2,3-dione) Bromfenac Impurity (7-(4-bromobenzoyl)indoline-2,3-dione) is a metabolite of Bromfenac sodium. Synonyms: AHR 11652. Grades: > 95%. CAS No. 241825-88-7. Molecular formula: C15H8BrNO3. Mole weight: 330.14. BOC Sciences 7
Epinephrine Impurity 4 An impurity of Epinephrine. Epinephrine is an endogenous catcholamine with combined α-and β-agonist activity and its principal sympathomimetic hormone is produced by the adrenal medulla. Synonyms: 1H-Indole-3-sulfonic acid, 2,3,5,6-tetrahydro-1-methyl-5,6-dioxo-; 2,3,5,6-Tetrahydro-1-methyl-5,6-dioxo-1H-indole-3-sulfonic acid; 3-Indolinesulfonic acid, 5,6-dihydro-1-methyl-5,6-dioxo-. CAS No. 94217-53-5. Molecular formula: C9H9NO5S. Mole weight: 243.24. BOC Sciences 8
Nintedanib Impurity 6 (Intedanib Impurity 6) BIBF 1202 is the major in-vivo metabolite of BIBF 1120, which is an oral triple angiokinase inhibitor targeting VEGFR, PDGFR, FGFR. It is a related compound of Intedanib, which is an indolinone derivative that inhibits angiokinase and an antitumor agent. It is a novel treatment modality in oncology through blockade of the vascular endothelial growth factor (VEGF) signaling pathway thus inhibition of tumor angiogenesis. Uses: Bibf 1202 is a novel treatment modality in oncology through blockade of the vascular endothelial growth factor (vegf) signaling pathway thus inhibition of tumor angiogenesis. Synonyms: BIBF-1202; BIBF 1202; BIBF1202. (3Z) -2, 3-Dihydro-3- [ [ [4- [methyl [ (4-methyl-1-piperazinyl) acetyl] amino] phenyl] amino] phenylmethylene] -2-oxo-1H-indole-6-carboxylic acid;(Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1 -yl)acetamido)phenyl)amino) (phenyl)methylene)-2-oxoindoline-6-carboxylic acid;Nintedanib Impurity 5. Grades: >98%. CAS No. 894783-71-2. Molecular formula: C30H31N5O4. Mole weight: 525.60. BOC Sciences 8
Noradrenochrome Noradrenochrome is an impurity of Noradrenaline, which is widely used as an injectable drug for the treatment of critically low blood pressure. Synonyms: 1H-Indole-5,6-dione, 2,3-dihydro-3-hydroxy-; Cyclized norepinephrine ortho-quinone; Norepinephrine Impurity 21; 3-Hydroxy-5,6-indolinedione. Grades: ≥95%. CAS No. 490-89-1. Molecular formula: C8H7NO3. Mole weight: 165.15. BOC Sciences 8
2(3H)-Benzofuranone 2(3H)-Benzofuranone is used in the synthesis of indolinones and analogues in the treatment of cancers. Also used in the synthesis of antitumor bis-indole derivatives. Impurity in the synthesis of Azoxystrobin (A965150). Group: Biochemicals. Alternative Names: 2,3-Dihydrobenzofuran-2-one; 2-Benzofuranone; 2-Coumaranone; 2-Coumarone; 3H-Benzofuran-2-one; Benzo[b]furan-2(3H)-one; Cumaranone; Isophthalide; NSC 227414; o-Hydroxyphenylacetic acid γ-lactone; α-Coumaranone. Grades: Highly Purified. CAS No. 553-86-6. Pack Sizes: 1g. US Biological Life Sciences. USBiological 3
Worldwide
2H-Indol-2-one,1,3-dihydro-4-[2-(propylamino)ethyl]- An impurity of Ropinirole. Ropinirole acts as a D2, D3 and D4 dopamine receptor agonist with highest affinity for D2. It is weakly active at the 5-HT2 and α2 receptors and is said to have virtually no affinity for the 5-HT1, GABA, mAChRs, α1 and β-adrenoreceptors. Uses: A metabolite of ropinirole. Synonyms: 4-(2-(Propylamino)ethyl)indolin-2-one; 1,3-Dihydro-4-[2-(propylamino)ethyl]-2H-indol-2-one; Monopropyl ropinirole. Grades: > 95%. CAS No. 106916-16-9. Molecular formula: C13H18N2O. Mole weight: 218.29. BOC Sciences 6
Aceclofenac EP Impurity I Aceclofenac EP Impurity I. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 1-(2,6-dichlorophenyl)indolin-2-one. CAS No. 15362-40-0. Molecular formula: C14H9Cl2NO. Mole weight: 278.13. Catalog: APB15362400. Alfa Chemistry Analytical Products 4
Diclofenac Amide A potential prodrug of Diclofenac and possible impurity during its commercial synthesis. Group: Biochemicals. Alternative Names: 1-(2,6-Dichlorophenyl)-1,3-dihydro-2H-indol-2-one; 1- (2, 6-Dichlorophenyl) oxindole; N-(2,6-dichlorophenyl)-2-indolinone; NSC 621845; Diclofenac Lactam; USP DIclofenac Related Compound A. Grades: Highly Purified. CAS No. 15362-40-0. Pack Sizes: 5mg, 10mg, 100mg. US Biological Life Sciences. USBiological 2
Worldwide
N-Despropyl Ropinirole HCl An impurity of Ropinirole. Ropinirole acts as a D2, D3, and D4 dopamine receptor agonist with highest affinity for D2. It is weakly active at the 5-HT2, and α2 receptors and is said to have virtually no affinity for the 5-HT1, GABA, mAChRs, α1, and β-adrenoreceptors. Synonyms: 4-(2-(propylamino)ethyl)indolin-2-one hydrochloride. Grades: > 95%. CAS No. 173990-76-6. Molecular formula: C13H18N2O.HCl. Mole weight: 254.76. BOC Sciences 9
Ropinirole EP Impurity D Ropinirole EP Impurity D. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-Despropyl Ropinirole; 4-(2-(propylamino)ethyl)indolin-2-one. CAS No. 106916-16-9. Molecular formula: C13H18N2O. Mole weight: 218.14. Catalog: APB106916169. Alfa Chemistry Analytical Products 4
Ropinirole Impurity 10 Ropinirole Impurity 10. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(2-chloroethyl)indolin-2-one. CAS No. 168476-59-3. Molecular formula: C10H10ClNO. Mole weight: 195.65. Catalog: APB168476593. Alfa Chemistry Analytical Products 4
Silodosin Impurity 7 A metabolite of Silodosin, Silodosin is an α1-adrenoceptor antagonist for the treatment of benign prostatic hypertrophy. Synonyms: (R) -5- (2- ( (2- (2- (2, 2, 2-Trifluoroethoxy) phenoxy) ethyl) amino) propyl) indoline-7-carboxamide; Deshydroxypropyl Silodosin. Grades: > 95%. Molecular formula: C22H26F3N3O3. Mole weight: 437.47. BOC Sciences 7
Silodosin Related Impurity An intermediate in the synthesis of (R)-Silodosin. Silodosin is an α1-adrenoceptor antagonist for the treatment of benign prostatic hypertrophy. Synonyms: 5-(2-Aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile; 3-(7-Cyano-5-(2-(amino)propyl)indolin-1-yl)propyl Benzoate. Grades: > 95%. CAS No. 1338365-54-0. Molecular formula: C22H25N3O2. Mole weight: 363.46. BOC Sciences 7
(S)-Silodosin (Silodosin Impurity 4) A stereoisomer of silodosin. Silodosin is an α1-adrenoceptor antagonist for the treatment of benign prostatic hypertrophy. Synonyms: (S) -1- (3-Hydroxypropyl) -5- (2- ( (2- (2- (2, 2, 2-trifluoroethoxy) phenoxy) ethyl) amino) propyl) indoline-7-carboxamide. Grades: > 95%. Molecular formula: C25H32F3N3O4. Mole weight: 495.55. BOC Sciences 7

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