Inositol Phosphate Phosphatase Suppliers USA
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Product | Description | |
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3α-Aminocholestane Quick inquiry Where to buy Suppliers range | 3α-Aminocholestane is an inhibitor of SH2 domain-containing inositol-5'-phosphatase 1 (SHP-1; IC50 = ~2.5 μM). It is selective for SHP-1 over SHP-2 and phosphatase and tensin homolog (PTEN; IC50s=>20 μM). Synonyms: 3AC; 5alpha-Cholestane-3alpha-amine. Grades: ≥95%. CAS No. 2206-20-4. Molecular formula: C27H49N. Mole weight: 387.7. | |
AR 244555 Quick inquiry Where to buy Suppliers range | AR 244555 is an inverse agonist of Mas G-protein signaling (IC50 values 186 and 348 nM in human and rat inositol phosphatase (IP) Gq coupling assays respectively). AR 244555 inhibited inositol 1,4,5-trisphosphate accumulation in AdMas-infected cells and attenuated the sarcomeric organization and cell enlargement observed in Mas overexpressing myocytes. AR 244555 caused an increase in coronary flow in rat hearts without causing arrhythmias, and provides protection from ischemia-reperfusion injury if administered either before ischemia or immediately before reperfusion. Synonyms: AR244555; AR 244555; AR-244555; (1'-but-3-enyl-5-chlorospiro[2H-indole-3,4'-piperidine]-1-yl)-(2,6-difluorophenyl)methanone. Grades: 99%. CAS No. 858350-62-6. Molecular formula: C23H23ClF2N2O. Mole weight: 416.89. | |
bpV(phen) potassium hydrate Quick inquiry Where to buy Suppliers range | BpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs) with IC50 of 38 nM. It also inhibits the vascular endothelial PTP-β with IC50 of 343 nM and PTP-1β with IC50 of 920 nM. At 0.1 mM, bpV(phen) inhibits SH2 domain-containing inositol 5'-phosphatase-2. Presumably by inhibiting insulin receptor kinase-associated PTPs, bpV(phen) activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase. Synonyms: Bisperoxovanadium(phen); Potassium Bisperoxo(1,10-phenanthroline) oxovanadate (V). Grades: ≥98%. CAS No. 171202-16-7. Molecular formula: C12H8N2O5V·K+(H2O)3. Mole weight: 404.3. | |
D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt Quick inquiry Where to buy Suppliers range | D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt is the octapotassium salt of D-myo-Inositol-1,3,4,5-tetrakisphosphate, which is the phosphorylation product of inositol 1,4,5-trisphosphate and the enantiomer of the naturally-occurring D-myo-inositol 1,3,4,5-tetrakisphosphate. It is a potent inhibitor of Ins (1,4,5)P3 5-phosphatase with IC50 value of ~150 nM. It facilitates Ca2+ influx by sensitizing Ins (1,4,5)P3-mediated activation of ICRAC. It is a useful intermediate. Synonyms: L-myo-Inositol 1,3,4,5-(tetrakis)phosphate potassium salt. Grades: ≥98% by HPLC. CAS No. 145843-69-2. Molecular formula: C6H8O18P4K8. Mole weight: 804.73. | |
PHYTASE Quick inquiry Where to buy Suppliers range | PHYTASE. Uses: Used for research and manufacturing. Group: Food Ingredients. Alternative Names: PHYTASE CRUDE, FROM WHEAT;phytase from wheat;6-Phytase, myo-Inositol-hexakisphosphate 6-phosphohydrolase, Phytate 6-phosphatase;Phytase from wheat,6-Phytase, Phytate 6-phosphatase, myo-Inositol-hexakisphosphate 6-phosphohydrolase;Phosphatase, phytate 6-;6-PHYTASE;phylase;MYO-INOSITOLHEXAKISPHOSPHATE 3-PHOSPHOHYDROLASE. CAS No. 9001-89-2. Pack Sizes: 1 kg. Product ID: CDF4-0058. | |
Potassium Bisperoxo (pyridine-2-carboxylato) oxovanadate Quick inquiry Where to buy Suppliers range | A novel Vanadium compound use as inhibitor of phosphatases, particularly inositol phosphatases. Used in the treatment of neurodegenerative diseases. Has antineoplastoc activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 68782-46-7. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
SHIP1 Inhibitor, 3AC (SH2-domain-containing inositol 5-phosphatase 1 (SHIP1) Inhibitor, 3AC, 3a-Aminocholestane) Quick inquiry Where to buy Suppliers range | A cell-permeable steroidal compound that acts as a highly selective SHIP1 activity inhibitor (IC50=10uM) over SHIP2 and PTEN (IC50>1mM in a phosphate release assay). Shown to boost the number of myeloid immunoregulatory cells and circulating granulocytes, and facilitate blood cell recovery in myelosuppressed hosts (60uM, i.p. in mice). Also, promotes apoptosis and reduces SHIP1-expressing KG1 and C1498 cell growth. SHIP2 Inhibitor, AS1938909 is also available. Group: Biochemicals. Grades: Highly Purified. CAS No. 2206-20-4. Pack Sizes: 10mg. Molecular Formula: C??H??N. US Biological Life Sciences. | Worldwide |
SHIP2 Inhibitor, AS1938909 (3- (2, 4-Dichlorobenzyl) oxy]-N- (2, 6-difluorobenzyl) thiophene-2-carboxamide, SH2 Domain-containing Inositol 5-phosphatase 2 (SHIP2) Inhibitor) Quick inquiry Where to buy Suppliers range | A cell-permeable thiophenecarboxamide compound that is shown to increase glucose metabolism and activate intracellular insulin signaling. Acts as a potent, competitive and reversible inhibitor of SHIP2 activity (Ki=0.44uM for hSHIP2) with moderate to excellent selectivity over SHIP1 and other related phosphatases (IC50=0.18, 0.57, 21, >50, >50 and >50uM for mSHIP2, hSHIP2, hSHIP1, hPTEN, h-synaptojanin and h-myotubularin, respectively). Elevates insulin-induced pAkt-Ser473 levels and enhances glucose transporter GLUT1 mRNA expression in L6 myotubes. SHIP1 Inhibitor, 3AC is also available. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
SHIP2 Inhibitor II, CPDA Quick inquiry Where to buy Suppliers range | A cell-permeable aminopyridine acetamide based compound that acts as an inhibitor of SH2 domain-containing inositol 5-phosphatase 2 (SHIP2) that can overcome insulin resistance in 3T3-L1 adipocytes. Enhances insulin-stimulated Akt phosphorylation (Thr308) in TNFa-treated 3T3-L1 adipocytes (~10uM) and in primary cultured neurons from rat cerebral cortex. Improves glucose tolerance in db/db mice (~300mg/kg b.i.d) without affecting their fasting glucose levels. Also reduces the expression levels of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??ClF?N?O?, Primary Target: SHIP2. US Biological Life Sciences. | Worldwide |