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INT (Iodonitrotetrazolium chloride) is a biochemical reagent mainly used in the iodonitrotetrazolium chloride (INT) colorimetric method to assess the metabolic activity of cells and the activity of enzymes [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Iodonitrotetrazolium chloride; p-Iodonitrotetrazolium Violet. CAS No. 146-68-9. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-15920.
INT 131
INT 131 is a hypoglycemic agent, displays robust glucose-lowering activity in rodent models of diabetes while exhibiting a reduced side-effects profile compared to marketed TZDs. Uses: Selective ppargamma modulator, enhancing insulin sensitivity. Synonyms: AMG-131; AMG 131; AMG131; INT-131; NT-131; INT-131; T-0903131; T-1312,4-Dichloro-N-(3,5-dichloro-4-quinolin-3-yloxyphenyl)benzenesulfonamide. Grades: ≥98%. CAS No. 315224-26-1. Molecular formula: C21H12Cl4N2O3S. Mole weight: 511.93.
INT-767
INT-767, a steride compound, has been found to be a inhibitor of FXR and TGF5 and could have probable effect against some liver and metabolic diseases. It was just planed a Phase II trial for Hepatic fibrosis. IC50: 30 nM(EC50, FXR), 630 nM(EC50, TGR5). Uses: Int-767 has been found to be a inhibitor of fxr and tgf5 and could have probable effect against some liver and metabolic diseases. Synonyms: INT-767; INT 767; INT767; CS-5007; CS 5007; CS5007; HY-12434; HY 12434; HY12434; Sulfuric acid sodium 3alpha,7alpha-dihydroxy-6alpha-ethyl-24-nor-5beta-cholane-23-yl ester salt. Grades: 98%. CAS No. 1000403-03-1. Molecular formula: C25H43NaO6S. Mole weight: 494.66.
INT-777
INT-777(S-EMCA) is a novel potent and selective TGR5 agonist with remarkable in vivo activity (EC50=0.82 uM). Synonyms: INT-777; INT 777; INT777; 6-EMCA; S-EMCA; ?HY-15677. Grades: >98%. CAS No. 1199796-29-6. Molecular formula: C27H46O5. Mole weight: 450.65.
Intedanib
Intedanib. Group: Biochemicals. Grades: Highly Purified. CAS No. 656247-17-5. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C31H33N5O4. US Biological Life Sciences.
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Integracin A
Integracin A is an unusual ester of two structurally related alkylresourcinols first isolated from a fungus, Cytonaema sp. in 2002 as a potent inhibitor of HIV-1. With the exception of this intial report, Integracin A has received little or no further attention. Group: Biochemicals. Grades: Highly Purified. CAS No. 224186-03-2. Pack Sizes: 1mg. US Biological Life Sciences.
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Integracin B
Integracin B is an unusual ester of two structurally related alkylresourcinols first isolated from a fungus, Cytonaema sp. in 2002 as a potent inhibitor of HIV-1 integrase. With the exception of this intial report, Integracin B has received little or no further attention. Group: Biochemicals. Grades: Highly Purified. CAS No. 224186-05-4. Pack Sizes: 1mg. US Biological Life Sciences.
A cell-permeable, hexapeptide containing a novel integrin-binding motif, SDV (a Type I PDZ-binding motif) that is shown to compete with vitronectin for the RGD-binding site of integrin avb3 (IC50=1.74pg/ml), in a chip-based assay. It is rapidly internalized into HUVECs, but not in NIH 3T3 cells, at a culture temperature of 37°C, a process which is mediated by caveolin and clathrin. At 10u/ml, this compound is shown to significantly inhibit the phosphorylation of ERK1/2 and MEK in HUVECs. Furthermore, it suppresses bFGF-induced proliferation of HUVECs, dose-dependently, and displays up-regulation of p53 and induction of apoptosis via activation of caspases-3, -8 and -9 at 50ug/ml. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
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Integrin Antagonist 1 hydrochloride
Integrin Antagonist 1 hydrochloride, a naphthyridine derivative, is a small molecule antagonist of integrin αvβ6. Synonyms: RGD-mimetic-1; 1-Pyrrolidinebutanoic acid, β-[3-(3,5-dimethyl-1H-pyrazol-1-yl)phenyl]-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-, (βS,3R)- (hydrochloride). CAS No. 1629249-40-6. Molecular formula: C29H38ClN5O2. Mole weight: 524.10.
Integrin Antagonists 27
Integrin Antagonists 27, as s novel anticancer agent., is a small molecule integrin αvβ3 antagonist. Uses: Anticancer agent. Synonyms: MDK-4976; Integrin Antagonist 27; MDK4976; MDK 4976; 3-{2-[(Z)-(1-{2-[(4-Methylphenyl)amino]-2-oxoethyl}-2,5-dioxo-4-imidazolidinylidene)methyl]-1H-pyrrol-1-yl}benzoic acid. Grades: ≥96%. CAS No. 593274-97-6. Molecular formula: C24H20N4O5. Mole weight: 444.44.
Integrin Binding Peptide
Integrin Binding Peptide is a peptide containing the cell adhesion sequence RGDSP, which is easily conjugated to carriers via Npys or maleimide chemistry. Synonyms: Ac-Gly-Cys-Gly-Tyr-Gly-Arg-Gly-Asp-Ser-Pro-Gly-NH2; N-acetyl-glycyl-L-cysteinyl-glycyl-L-tyrosyl-glycyl-L-arginyl-glycyl-L-alpha-aspartyl-L-seryl-L-prolyl-glycinamide; Glycinamide, N-acetylglycyl-L-cysteinylglycyl-L-tyrosylglycyl-L-arginylglycyl-L-α-aspartyl-L-seryl-L-prolyl-. Grades: ≥95%. CAS No. 278792-07-7. Molecular formula: C42H63N15O16S. Mole weight: 1066.12.
Integrin Binding Peptide
Integrin Binding Peptide is derived by fibronectin. Integrin Binding Peptide can be used for PEG hydrogel preparation [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 278792-07-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2532.
Integrin ?v?3 Antagonist, P11
The Integrin ?v?3 Antagonist, P11 controls the biological activity of Integrin ?v?3. Group: Fluorescence/luminescence spectroscopy.
Intepirdine
Intepirdine (SB742457) is a highly selective 5-HT6 receptor antagonist with pKi of 9.63; exhibits >100-fold selectivity over other receptors. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB-742457; GSK-742457; RVT-101. CAS No. 607742-69-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14339.
Interferon-?A human
?95%, suitable for cell culture, buffered aqueous solution, recombinant, expressed in E. coli. Group: Fluorescence/luminescence spectroscopy.
A nonpeptidic thiophenylmethanamine compound that binds interferon-a (Kd= 4uM for human IFN-a) and prevents IFN-a and IFNAR interaction-dependent IFN-a production in murine BM-pDCs (bone marrow-derived plasmacytoid dendritic cells) cultures upon MVA infection (IC50<4.5uM), while exhibiting no inhibitory effect against IL-12 production in the same cultures when applied at non-toxic concentrations (<4.5uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences.
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Interferon-? from mouse
?98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Interferon-? from rat
?97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Interferon-? human
recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Interferon-? human
recombinant, expressed in E. coli, ?98% (SDS-PAGE), lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Interferon-?-Inducible Protein-10 human
?97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder. Group: Fluorescence/luminescence spectroscopy.
Interferon-Inducible T Cell ? Chemoattractant human
?97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Interiorin
Interiorin can be isolated from Kadsura heteroclita and has moderate anti-HIV activity with an EC50 value of 1.6 lg/mL [1]. Uses: Scientific research. Group: Natural products. CAS No. 119139-55-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N11949.
Interleukin-10/Fc Chimera (non-lytic) from mouse
>98% (SDS-PAGE), recombinant, expressed in CHO cells, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy.
>97% (SDS-PAGE), recombinant, expressed in E. coli, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Interleukin-10 from rat
>95% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder. Group: Fluorescence/luminescence spectroscopy.
Interleukin-10 human
?97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Interleukin-11 from mouse
>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder. Group: Fluorescence/luminescence spectroscopy.
Interleukin-11 human
>97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Interleukin-12 from mouse
?97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Interleukin-12 human
?97% (SDS-PAGE and N-terminal analysis), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Interleukin-13 from mouse
?97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Interleukin-13 human
?97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Interleukin-15 human
>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Interleukin-17A human
?98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Interleukin-17 from mouse
?97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Interleukin-18 from rat
>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder. Group: Fluorescence/luminescence spectroscopy.
Interleukin-1β Fragment 163-171 human
Interleukin-1β Fragment 163-171 human is a peptide involved in the regulation of immune responses, inflammatory reactions, and hematopoiesis. Synonyms: H-Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH; L-valyl-L-glutaminyl-glycyl-L-alpha-glutamyl-L-alpha-glutamyl-L-seryl-L-asparagyl-L-alpha-aspartyl-L-lysine; L-Lysine, L-valyl-L-glutaminylglycyl-L-α-glutamyl-L-α-glutamyl-L-seryl-L-asparaginyl-L-α-aspartyl-; L-Lysine, N2-[N-[N2-[N-[N-[N-[N-(N2-L-valyl-L-glutaminyl)glycyl]-L-α-glutamyl]-L-α-glutamyl]-L-seryl]-L-asparaginyl]-L-α-aspartyl]-; L-Valyl-L-glutaminylglycyl-L-α-glutamyl-L-α-glutamyl-L-seryl-L-asparaginyl-L-α-aspartyl-L-lysine; Sclavo peptide; β-Interleukin I (163-171), human. Grades: 95%. CAS No. 106021-96-9. Molecular formula: C39H64N12O19. Mole weight: 1004.99.
Interleukin-21 from mouse
?97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Interleukin-2/Fc Chimera (non-lytic) from mouse
>98% (SDS-PAGE), recombinant, expressed in CHO cells, solution. Group: Fluorescence/luminescence spectroscopy.
Interleukin-2 from mouse
IL-2, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Interleukin-2 human
IL-2, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
IL-3, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Interleukin-4/Fc Chimera (non-lytic) from mouse
>98% (SDS-PAGE), recombinant, expressed in CHO cells, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy.
Interleukin-4 from mouse
IL-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Interleukin-4 from rat
recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ?97% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy.
Interleukin-4 human
IL-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Interleukin-5 from mouse
?97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Interleukin-5 human
recombinant, expressed in baculovirus infected Sf21 cells, ?97% (SDS-PAGE), lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Interleukin-7 from mouse
?97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Interleukin-7 human
?98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Interleukin-8 human
?98% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Icp55 removes the destabilizing N-terminal amino acid residues that are left after cleavage by the mitochondrial processing peptidase, leading to the stabilisation of the substrate. The enzyme can remove single amino acids or a short peptide, as in the case of cysteine desulfurase (EC 2.8.1.7), where three amino acids are removed. Group: Enzymes. Synonyms: Icp55; mitochondrial intermediate cleaving peptidase 55 kDa. Enzyme Commission Number: EC 3.4.11.26. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4023; intermediate cleaving peptidase 55; EC 3.4.11.26; Icp55; mitochondrial intermediate cleaving peptidase 55 kDa. Cat No: EXWM-4023.
Internal Mammary Artery Endothelial Cells, Human (Frozen)
Passage 3 cells are shipped in proliferating culture with a confluence of >90%. ENDO-Growth medium containing 5% serum and growth supplement is recommended for culture. Cells have an average population doubling level of >16 when cultured. Group: Biologicals. Grades: Cell Culture Grade. Pack Sizes: 1ml. US Biological Life Sciences.
Worldwide
Internal Mammary Artery Endothelial Cells, Human (T-25 flask)
Passage 3 cells are shipped in proliferating culture with a confluence of >90%. ENDO-Growth medium containing 5% serum and growth supplement is recommended for culture. Cells have an average population doubling level of >16 when cultured. Group: Biologicals. Grades: Cell Culture Grade. Pack Sizes: T-25 flask. US Biological Life Sciences.
Worldwide
interstitial collagenase
The enzyme takes its name from substrates of the interstitial collagen group - types I, II and III, all of which are cleaved in the helical domain. However, α-macroglobulins are cleaved much more rapidly. The enzyme is widely distributed in vertebrate animals. Type example of peptidase family M10. Group: Enzymes. Synonyms: vertebrate collagenase; matrix metalloproteinase 1. Enzyme Commission Number: EC 3.4.24.7. CAS No. 9001-12-1. Matrix Metalloproteinase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4353; interstitial collagenase; EC 3.4.24.7; 9001-12-1; vertebrate collagenase; matrix metalloproteinase 1. Cat No: EXWM-4353.
Intetumumab
Intetumumab (CNTO 95) is a potent anti- EGFR monoclonal antibody that is glycoengineered for enhanced antibody-dependent cellular cytotoxicity (ADCC). Intetumumab can be used in research of cancer [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: CNTO 95; Anti-Human CD51 Recombinant Antibody. CAS No. 725735-28-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99296.
INT Formazan, GR
INT Formazan, GR. Group: other glass and ceramic materials. CAS No. 7781-49-9. Product ID: N'- (4-iodoanilino) -N- (4-nitrophenyl) iminobenzenecarboximidamide. Molecular formula: 471.3g/mol. Mole weight: C19H14IN5O2. C1=CC=C (C=C1)C (=NNC2=CC=C (C=C2)I)N=NC3=CC=C (C=C3)[N+] (=O)[O-]. InChI=1S/C19H14IN5O2/c20-15-6-8-16 (9-7-15)21-23-19 (14-4-2-1-3-5-14)24-22-17-10-12-18 (13-11-17)25 (26)27/h1-13, 21H/b23-19+, 24-22?. BWJJSYVJOLHQFF-GECZPBSJSA-N.
Intiquinatine
Intiquinatine may have potential anticancer activity. Uses: May have potential anticancer activity. Synonyms: (R)-2-(4-((7-bromoquinolin-2-yl)oxy)phenoxy)propanoic acid. Grades: ≥98%. CAS No. 445041-75-8. Molecular formula: C18H14BrNO4. Mole weight: 388.21.
Intoplicine
Intoplicine (RP 60475), an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. Intoplicine strongly binds DNA (KA = 2 x 105 /M) and thereby increases the length of linear DNA. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 11-((3-(Dimethylamino)propyl)amino)-8-methyl-7H-benzo(e)pyrido(4,3-b)indol-3-ol; UNII-FB2CIN6HMI. Product Category: Inhibitors. CAS No. 125974-72-3. Molecular formula: C21H24N4O. Mole weight: 348.44. Purity: 0.96. IUPACName: Intoplicine. Canonical SMILES: CC1=CN=C(C2=C1NC3=C2C4=C(C=C3)C=C(C=C4)O)NCCCN(C)C. Density: 1.286g/cm³. Product ID: ACM125974723. Alfa Chemistry ISO 9001:2015 Certified.
Intralipid 20% is a safe fat emulsion that can be used as a nutritional supplement. Intralipid 20% effectively inhibits the opening of the mitochondrial permeability transition pore, effectively protecting the heart from ischaemia-reperfusion injury and has some potential to modulate the innate immune response [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 68890-65-3. Pack Sizes: 100 mg. Product ID: HY-131370B.