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| Product | Description | |
|---|---|---|
| Integrin Binding Peptide | Integrin Binding Peptide is a peptide containing the cell adhesion sequence RGDSP, which is easily conjugated to carriers via Npys or maleimide chemistry. Synonyms: Ac-Gly-Cys-Gly-Tyr-Gly-Arg-Gly-Asp-Ser-Pro-Gly-NH2; N-acetyl-glycyl-L-cysteinyl-glycyl-L-tyrosyl-glycyl-L-arginyl-glycyl-L-alpha-aspartyl-L-seryl-L-prolyl-glycinamide; Glycinamide, N-acetylglycyl-L-cysteinylglycyl-L-tyrosylglycyl-L-arginylglycyl-L-α-aspartyl-L-seryl-L-prolyl-. Grade: ≥95%. CAS No. 278792-07-7. Molecular formula: C42H63N15O16S. Mole weight: 1066.12. |  |
| Integrin Binding Peptide | Integrin Binding Peptide is derived by fibronectin. Integrin Binding Peptide can be used for PEG hydrogel preparation [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 278792-07-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2532. |  |
| (2R, ? 4R) ? -? 1-? Boc-? N-? Fmoc-? 4-? amino-? pyrrolidine-? 2-? carboxylic Acid | (2R, ? 4R) ? -? 1-? Boc-? N-? Fmoc-? 4-? amino-? pyrrolidine-? 2-? carboxylic Acid can be used as reactant/reagent in synthetic preparation of KMI-008 peptide derivatives and proline-based peptidomimetic analogs and determination of their activity as BACE1 inhibitors ( β-secretase inhibitors). It can also be used as reagent/reactant for preparation of aminoproline residues for solid phase synthesis of integrin binding cyclic peptides by bromination, azidation and protection / deprotection protocol. Group: Biochemicals. Grades: Highly Purified. CAS No. 1018332-24-5. Pack Sizes: 50mg, 100mg. Molecular Formula: C25H28N2O6, Molecular Weight: 452.5. US Biological Life Sciences. |  Worldwide |
| (2S, 4S) -4-Amino-1, 2-pyrrolidinedicarboxyl ic Acid 1-(1,1-Dimethylethyl) Ester | (2S, 4S) -4-Amino-1, 2-pyrrolidinedicarboxyl ic Acid 1-(1,1-Dimethylethyl) Ester is used to prepare aminoproline residues for solid phase synthesis of integrin binding cyclic peptides. Group: Biochemicals. Grades: Highly Purified. CAS No. 132622-66-3. Pack Sizes: 500mg, 5g. Molecular Formula: C10H18N2O4, Molecular Weight: 230.26. US Biological Life Sciences. | Worldwide |
| Arg-Gly-Asp-Ser | Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. It is a tetrapeptide found on fibronectin, fibrinogen α, and von Willebrand factor, but not vitronectin or collagen. It decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. It inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen α, and von Willebrand factor. It promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro. It also blocks the attachment of certain pathogens to cells. Uses: Platelet aggregation inhibitors. Synonyms: Arg Gly Asp Ser; RGDS peptide; Fibronectin Inhibitor. Grade: >98%. CAS No. 91037-65-9. Molecular formula: C15H27N7O8. Mole weight: 433.42. | |
| ATN 161 | ATN-161 is a small peptide antagonist of integrin alpha5beta1 with potential antineoplastic activity. ATN-161 selectively binds to and blocks the receptor for integrin alpha5beta1, thereby preventing integrin alpha5beta1 binding. Synonyms: ATN161; ATN-161; Ac-PHSCN-NH2; N-acetyl-L-prolyl-L-histidyl-L-seryl-L-cysteinyl-L-asparaginamide. Grade: >98%. CAS No. 262438-43-7. Molecular formula: C23H35N9O8S. Mole weight: 597.65. | |
| Cyclo(-Arg-Ala-Asp-D-Phe-Cys) | Cyclo(-Arg-Ala-Asp-D-Phe-Cys) is a control peptide for the αvβ3 integrin binding cyclic RGD peptide c(RGDfC). Synonyms: c(RADfC); Cyclo(L-alanyl-L-α-aspartyl-D-phenylalanyl-L-cysteinyl-L-arginyl). Grade: ≥95%. CAS No. 1055991-02-0. Molecular formula: C25H36N8O7S. Mole weight: 592.68. | |
| Cyclo(RADfK) | Cyclo(RADfK) is a selective α(V)β(3) integrin ligand. It has been used for research, therapy, and diagnosis of neoangiogenesis. It is also used as a negative control for the cyclo (-RGDfK-), the RGD peptide, which are modulators of cell adhesion and are recognized by several members of the integrin family. It has low affinity binding to integrin peptides. Uses: Cyclo(radfk) has been used for research, therapy, and diagnosis of neoangiogenesis. it is also used as a negative control for the cyclo (-rgdfk-), the rgd peptide. Synonyms: c(RADfK); cyclo[L-alanyl-L-alpha-aspartyl-D-phenylalanyl-L-lysyl-L-arginyl]. Grade: ≥95%. CAS No. 756500-23-9. Molecular formula: C28H43N9O7. Mole weight: 617.70. | |
| Cyclo(-RGDfK) | Cyclo(-RGDfK) is a potent and selective inhibitor of the ?v?3 integrin, with an IC50 of 0.94 nM[1]. Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the ?v?3 integrin on the cell surface[2]. Uses: Scientific research. Group: Peptides. CAS No. 161552-03-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0023. | |
| Gly-Arg-Gly-Asp-Ser | Gly-Arg-Gly-Asp-Ser (GRGDS) is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC 50 of ~5 and ~6.5 μM [1]. Uses: Scientific research. Group: Peptides. Alternative Names: GRGDS. CAS No. 96426-21-0. Pack Sizes: 2 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0295. | |
| GRGDSPK | GRGDSPK (EMD 56574) is a peptide incluing Arg-Gly-Asp (RGD). GRGDSPK (EMD 56574) is an competitive and reversible inhibitory peptide for inhibiting integrin-fibronectin binding. GRGDSPK is used to study the role of integrins in bone formation and resorption[1][2]. Uses: Scientific research. Group: Peptides. Alternative Names: EMD 56574. CAS No. 111119-28-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P0322. | |
| Hexapeptide-10 Acetate | Hexapeptide-10 Acetate is a synthetic peptide. It increases the synthesis of laminin V and α6-integrin to promote cell binding, with extraordinary visible skin restructuring and firming abilities. Molecular formula: C30H57N7O10. Mole weight: 675.81. | |
| iRGD peptide | iRGD peptide is a 9-amino acid cyclic peptide, triggers tissue penetration of agents by first binding to ?v-integrins, then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties. Uses: Scientific research. Group: Peptides. Alternative Names: c(CRGDKGPDC). CAS No. 1392278-76-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0122. | |
| LDV-FITC | LDV-FITC, a fluorescent peptide, is a FITC-conjugated LDV peptide (HY-P2267). LDV-FITC binds to the α4β1 integrin with high affinity ( K d : 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn 2+ respectively). LDV-FITC can be used to detect α4β1 integrin affinity [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 1207610-07-8. Pack Sizes: 1 mg. Product ID: HY-P1188. | |
| RGD peptide (GRGDNP) | RGD peptide (GRGDNP) is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) plays an important role in cell adhesion, migration, growth, and differentiation [1] [2] [3]. Uses: Scientific research. Group: Peptides. CAS No. 114681-65-1. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P1740. | |
| SB-273005 | SB-273005 is an orally active non-peptide ?v?3 integrin antagonist with Ki values of 1.2 nM and 0.3 nM for ?v?3 and ?v?5, respectively. SB-273005 blocks the binding of integrins to the RGD sequence in the extracellular matrix. SB-273005 inhibits Rictor phosphorylation and reduces IL-10 secretion. SB-273005 inhibits inflammation, prevents bone loss, regulates vascular smooth muscle function, and reverses pregnancy-induced immune deviation. SB-273005 can be used in the study of rheumatoid arthritis, osteoporosis, and aneurysms. [1][2][3][4][5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 205678-31-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19307. | |
| Arg-Gly-Asp | RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins. Synonyms: Arginyl-Glycyl-Aspartic acid; RGD peptide. Grade: Min 98%. CAS No. 99896-85-2. Molecular formula: C12H22N6O6. Mole weight: 346.34. | |
| Cilengitide | Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(V)beta(3) and alpha(V)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis. It is being studied for the treatment of glioblastoma. Synonyms: 2-[(2S,5R,8S,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-7-methyl-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid. Grade: ≥98%. CAS No. 188968-51-6. Molecular formula: C27H40N8O7. Mole weight: 588.65. | |
| Fluciclatide F-18 | Fluciclatide-F18 is a radiopharmaceutical compound of a small synthetic cyclic peptide containing an RGD-sequence (Arg-Gly-Asp) labeled with the positron-emitting isotope fluorine F 18 that may be used to selectively image tumor cells and tumor vasculature by PET imaging. The RGD motif of fluciclatide F 18 selectively binds to the alphaVbeta3 integrin receptor, commonly upregulated on the surfaces of tumor cells and endothelial cells of tumor vasculature. This agent may be of use in visualizing and quantifying the development of tumor vascularity in response to antiangiogenic agents. Synonyms: [18F]AH111585; 18F-Fluciclatide; Fluciclatide (f-18). CAS No. 879894-01-6. Molecular formula: C75H115FN18O27S3. Mole weight: 1815.02. | |
| LDV | LDV is a non-fluorescent analog of LDV-FITC. LDV is a α4β1 integrin (VLA-4) ligand, and binds α4β1 integrin in leukemia cells [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 1155866-55-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2267. | |
| RGD | RGD is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integrins. Uses: Scientific research. Group: Peptides. CAS No. 99896-85-2. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P0278. | |
| RGD Trifluoroacetate | RGD Trifluoroacetate is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; RGD Trifluoroacetate binds to integrins. Uses: Scientific research. Group: Peptides. CAS No. 2378808-45-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0278A. | |
| XJ735 | XJ735, a RGD peptidomimetic αVβ3 integrin antagonist, contains anionic and cationic binding sites that straddle the RGD binding domain of the αvβ3 integrin. Synonyms: XJ 735; XJ-735; Cyclo[L-alanyl-L-arginylglycyl-L-α-aspartyl-3-(aminomethyl)benzoyl]; 3,6,9,12,15-Pentaazabicyclo[15.3.1]heneicosa-1(21),17,19-triene-5-acetic acid, 11-[3-[(aminoiminomethyl)amino]propyl]-14-methyl-4,7,10,13,16-pentaoxo-, (5S,11S,14S)-. Grade: ≥95%. CAS No. 153381-95-4. Molecular formula: C23H32N8O7. Mole weight: 532.55. | |
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