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Product | Description | |
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ImmunoglobulinG1, anti-(human interleukin 5) (human-mouse monoclonal SB-240563 g1-chain),disulfide with human-mouse monoclonal SB-240563 k-chain, dimer (9CI) Quick inquiry Where to buy Suppliers range | ImmunoglobulinG1, anti-(human interleukin 5) (human-mouse monoclonal SB-240563 g1-chain),disulfide with human-mouse monoclonal SB-240563 k-chain, dimer (9CI). Group: Heterocyclic Organic Compound. CAS No. 196078-29-2. | |
β-Interleukin I (163-171), human acetate Quick inquiry Where to buy Suppliers range | β-Interleukin I (163-171), human acetate is a peptide involved in the regulation of immune responses, inflammatory reactions, and hematopoiesis. Synonyms: H-Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH.CH3CO2H; L-valyl-L-glutaminyl-glycyl-L-alpha-glutamyl-L-alpha-glutamyl-L-seryl-L-asparagyl-L-alpha-aspartyl-L-lysine acetic acid. Grades: ≥95%. CAS No. 2763583-73-7. Molecular formula: C41H68N12O21. Mole weight: 1065.05. | |
Interleukin-1β Fragment 163-171 human Quick inquiry Where to buy Suppliers range | Interleukin-1β Fragment 163-171 human is a peptide involved in the regulation of immune responses, inflammatory reactions, and hematopoiesis. Synonyms: H-Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH; L-valyl-L-glutaminyl-glycyl-L-alpha-glutamyl-L-alpha-glutamyl-L-seryl-L-asparagyl-L-alpha-aspartyl-L-lysine; L-Lysine, L-valyl-L-glutaminylglycyl-L-α-glutamyl-L-α-glutamyl-L-seryl-L-asparaginyl-L-α-aspartyl-; L-Lysine, N2-[N-[N2-[N-[N-[N-[N-(N2-L-valyl-L-glutaminyl)glycyl]-L-α-glutamyl]-L-α-glutamyl]-L-seryl]-L-asparaginyl]-L-α-aspartyl]-; L-Valyl-L-glutaminylglycyl-L-α-glutamyl-L-α-glutamyl-L-seryl-L-asparaginyl-L-α-aspartyl-L-lysine; Sclavo peptide; β-Interleukin I (163-171), human. Grades: 95%. CAS No. 106021-96-9. Molecular formula: C39H64N12O19. Mole weight: 1004.99. | |
Asiaticoside Quick inquiry Where to buy Suppliers range | Antibacterial. Human collagen I synthesis inducer. Anti-wrinkle activity. Shows wound healing activity. Enhances normal human skin cell migration, attachment and growth. Suppresses collagen expression and TGF-beta/Smad signaling by inducing Smad7 and inhibiting TGF-betaRI and TGF-betaRII. Anti-inflammatory. Anti-gastric ulcer. Mitogen-activated protein kinases (MAPKs), nuclear factor-kappaB (NF-kappaB), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOSII) expression, production of serum tumor necrosis factor (TNF-alpha) and interleukin-6 (IL-6) inhibitor. Apoptosis inducer in cancer cells. Enhances antitumor activity of vincristine in cancer cells. Might be useful in cancer chemotherapy. Anxiolytic. Antidepressant-like activity. Hepatoprotective effects. CYP2C19 and CYP3A4 inhibitor. Neuroprotective. Antileishmanial activity. cPLA2 and sPLA2 inhibitor. Group: Biochemicals. Alternative Names: Blastostimulina, Centelase, Emdecassol, Madecassol, Marticassol, FK1080, BRN 0078195, NSC 166062. Grades: Highly Purified. CAS No. 16830-15-2. Pack Sizes: 10mg, 50mg. Molecular Formula: C48H78O19. US Biological Life Sciences. | Worldwide |
Brodalumab Quick inquiry Where to buy Suppliers range | Brodalumab is a human monoclonal antibody that binds to the interleukin-17 receptor and inhibits the binding of IL-17 to its receptor. Brodalumab has been approved for the treatment of moderate to severe plaque psoriasis. Synonyms: Siliq; Kyntheum; AMG-827; KHK-4827; anti-IL17RA. CAS No. 1174395-19-7. | |
Butein Quick inquiry Where to buy Suppliers range | Butrin, isobutrin, and butein from medicinal plant Butea monosperma selectively inhibit nuclear factor-κB in activated human mast cells: suppression of tumor necrosis factor-α, interleukin (IL)-6, and IL-8. Anti-inflammatory agent. Group: Biochemicals. Alternative Names: (2E)-1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one; 2',3,4,4'-Tetrahydroxychalcone. Grades: Highly Purified. CAS No. 487-52-5. Pack Sizes: 20mg, 50mg, 100mg, 250mg. Molecular Formula: C??H??O?, Molecular Weight: 272.25. US Biological Life Sciences. | Worldwide |
Celastramycin A Quick inquiry Where to buy Suppliers range | Celastramycin A is a bioactive compound isolated from endophytic bacteria. Celastramycin A exhibited high activity against a series of multiresistent bacteria and mycobacteria. It inhibits the growth of Gram-positive bacteria and mycobacteria with minimal inhibitory concentration (MIC). Celastramycin A suppresses the production of interleukin-8 in human umbilical vein endothelial cells as stimulated by tumor necrosis factor-α with IC50 of 0.01 μg/ml. It can also be used as a lead compound for novel immunosuppressive agents. Grades: ≥97%. CAS No. 491600-94-3. Molecular formula: C17H18Cl3NO3. Mole weight: 390.69. | |
CJ-14877 Quick inquiry Where to buy Suppliers range | It is originally isolated from Marasmiellus sp. CL21624. CJ-14877 inhibited human blood interleukin-1β (IL-1β) production induced by lipoglycan (LPS) with an IC50 of 0.1 μmol/L. Synonyms: 2-Pyridinecarboxylic acid, 5-[(1S,2S)-1,2-dihydroxypropyl]-, methyl ester. Molecular formula: C10H13NO4. Mole weight: 211.21. | |
CJ-14897 Quick inquiry Where to buy Suppliers range | It is originally isolated from Marasmiellus sp. CL21624. CJ-14897 inhibited human blood interleukin-1β (IL-1β) production induced by lipoglycan (LPS) with an IC50 of 0.059 μmol/L. Synonyms: (+)-CJ-14897; 2-Pyridinecarboxylic acid, 5-((1S,2S)-2-(acetyloxy)-1-hydroxypropyl)-, methyl ester; UNII-10M04QP59K. CAS No. 377755-95-8. Molecular formula: C12H15NO5. Mole weight: 253.25. | |
EFAVIRENZ Quick inquiry Where to buy Suppliers range | efavirenz, 154598-52-4, Sustiva, Stocrin, DMP-266, DMP 266, (-)-Efavirenz, EFV, (4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one, L-743726, (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one, Eravirenz, Viraday, efavirenz, (S)-isomer, Efavirenz teva, (Rac)-Efavirenz, L-743,726, (S)-Efavirenz, Strocin (TM), Sustiva (TM), Sustiva (TN), (4S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one, L 743726, HSDB 7163, (S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one, NSC-742403, Efavirenz [USP:INN:BAN], UNII-JE6H2O27P8, (-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE, (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one, JE6H2O27P8, Met-SDF-1.beta. & Efavirenz, DTXSID9046029, CHEBI:119486, NSC742403, (S)-6-Chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one, (S)-6-CHLORO-4-(CYCLOPROPYLETHYNYL)-4-(TRIFLUOROMETHYL)-1H-BENZO[D][1,3]OXAZIN-2(4H)-ONE, 2H-3,1-Benzoxazin-2-one, 6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4S)-, 6-chloro-4-(2-cyclopropyl-1-ethynyl)-4-trifluoromethyl-(4S)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one, EFZ, (Rac)-DMP 266; (Rac)-EFV; (Rac)-L-743726, DTXCID7026029, Met-Stromal Cell-derived Factor-1.beta. (Human) & Efavirenz, MFCD05662344, (4S)-6-Chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one, (4S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one, SMR000466351, CAS-154598-52-4, SR-01000759360, L-741211, L-743725, Efavirenzum, C14-H9-Cl-F3-N-O2, zoxazin-2-one, 1ikv, 1ikw, Efavirenz- Bio-X, NCGC00159337-02, Efavirenz, (S), Efavirenz & PLGA, Stocrin (TN), Efavirenz & IFNL1, Efavirenz & IFNL2, Efavirenz & IFNL3, Efavirenz & IL-29, Efavirenz (JAN/INN), Efavirenz [INN:BAN], EFAVIRENZ [INN], EFAVIRENZ [JAN], DMP-266; Efavirenz, Efavirenz & IL-28A, Efavirenz & IL-28B, EFAVIRENZ [MI], EFAVIRENZ [HSDB], EFAVIRENZ [USAN], EFV & Interleukin 29, EFAVIRENZ [VANDF], EFV & Interleukin 28A, EFV & Interleukin 28B, EFV & PLGA, D07HVY, EFAVIRENZ [MART.], EFAVIRENZ [USP-RS], EFAVIRENZ [WHO-DD], EFAVIRENZ [WHO- | |
Elubrixin Quick inquiry Where to buy Suppliers range | Elubrixin is a interleukin 8 inhibitor and CXCR2 selective antagonist. It is potentially useful for Inflammatory bowel disease therapies. It inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans. It may be an effective agent in neutrophil-predominant diseases. It was developed by GlaxoSmithKline and was in clinic phase 2 trials, but now it is terminated. Uses: Elubrixin is potentially useful for inflammatory bowel disease therapies. it may be an effective agent in neutrophil-predominant diseases. Synonyms: 1-(2-Chloro-3-fluorophenyl)-3-(4-chloro-2-hydroxy-3-piperazin-1-ylsulfonylphenyl)urea;SB-656933;SB656933;SB-656933-AAF;SB-656933-AAA;SB656933AAA;SB656933AAF;1-(4-Chloro-2-hydroxy-3-(piperazin-1-ylsulfonyl)phenyl)-3-(2-chloro-3-fluorophenyl)urea. Grades: 98%. CAS No. 688763-64-6. Molecular formula: C17H17Cl2FN4O4S. Mole weight: 463.30. | |
Etanercept Quick inquiry Where to buy Suppliers range | Etanercept inhibits in vitro the activity of human TNF and is efficacious in many in vivo models of inflammation, including arthritis. Etanercept competitively inhibits the binding of both TNF-α and TNF-β (lymphotoxin-α) to cell surface TNF receptors, rendering TNF biologically inactive. It also modulates indirectly different biological responses that are induced or regulated by TNF, such as the expression of adhesion molecules E-selectin and to a lesser extent intercellular adhesion molecule 1 (ICAM-1), the production of interleukin-6 (IL-6) and matrix metalloproteinase 3 (MMP-3) (stromelysin), as well as IL1. Synonyms: 1-235-Tumor necrosisfactor receptor (human) fusion protein with 236-467-immunoglobulin G1 (human g1-chain Fc fragment); TNFR-Fc fusion protein; Etanercept; Embrel; Enbrel; rhu-TNFR-Fc. Grades: 95%. CAS No. 185243-69-0. Molecular formula: C2224H3472N618O701S36. | |
Fezakinumab Quick inquiry Where to buy Suppliers range | Fezakinumab is a human monoclonal antibody that targets interleukin-22. Fezakinumab has been developed for the treatment of psoriasis and rheumatoid arthritis. Synonyms: ILV 094; ILV-094; ILV094. CAS No. 1007106-86-6. | |
FSL-1-FLAG Quick inquiry Where to buy Suppliers range | Lipopeptide FSL-1, synthesized on the basis of the N-terminal structure of M. salivarium lipoprotein, can induce ICAM-1 expression on the surface of human gingival fibroblasts. In addition, it induces the production of monocyte chemoattractant protein 1, interleukin-6 (IL-6), and IL-8. It activates macrophages to produce tumor necrosis factor-alpha. Synonyms: Fibroblast Stimulating Lipopeptide 1 FLAG-tag; H-Cys((RS)-2,3-di(palmitoyloxy)-propyl)-Gly-Asp-Pro-Lys-His-Pro-Lys-Ser-Phe-Asp-Tyr-Lys-Asp-Asp-Asp-Asp-Lys-OH; L-Lysine, S-[2,3-bis[(1-oxohexadecyl)oxy]propyl]-L-cysteinylglycyl-L-α-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl-L-phenylalanyl-L-α-aspartyl-L-tyrosyl-L-lysyl-L-α-aspartyl-L-α-aspartyl-L-α-aspartyl-L-α-aspartyl-. Grades: ≥95%. CAS No. 2243206-97-3. Molecular formula: C125H198N24O37S. Mole weight: 2661.15. | |
IL2 Quick inquiry Where to buy Suppliers range | Recombinant human IL - 2; Interleukin-2 is a secreted cytokine, also called IL-2. Aldesleukin (IL-2 made in the laboratory) is being used as a biological response modifier to boost the immune system in cancer therapy. Synonyms: Iloprost R-isomer; 74843-13-3; 16(R)-Iloprost; 16-(R)-Iloprost; UNII-AHG2128QW6; AHG2128QW6; (5E)-5-((3aS,4R,5R,6aS)-5-Hydroxy-4-((1E,3S,4R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)pentanoic acid; (5E)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(E,3S,4R)-3-hydroxy-4-methyloct-1-en-6-ynyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid; Pentanoic acid, 5-((3aS,4R,5R,6aS)-hexahydro-5-hydroxy-4-((1E,3S,4R)-3-hydroxy-4-methyl-1-octen-6-ynyl)-2(1H)-pentalenylidene)-, (5E)-; (5e)-5-[(3as,4r,5r,6as)-5-Hydroxy-4-[(1e,3s,4r)-3-Hydroxy-4-Methyloct-1-En-6-Yn-1-Yl]hexahydropentalen-2(1h)-Ylidene]pentanoic Acid; IL2; SCHEMBL21509107; AKOS040755122; PD021248; Q27273925; 5-((3AS,4R,5R,6aS,E)-5-hydroxy-4-((3S,4R,E)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)pentanoic acid. Molecular formula: C22H32O4. Mole weight: 360.5. | |
Imiquimod Quick inquiry Where to buy Suppliers range | Cell-permeable. Topical immune response modifier that displays anti-angiogenic, anti-viral and anti-inflammatory properties. Up-regulates IL-18 and down-regulates MMP-9 through recognition of Toll-like receptor 7 (TLR7) and subsequent activation of MyD88-dependent pathway. Stimulates proinflammatory cytokine production interferon-alpha (IFN-alpha), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) and activates NF-kappaB. Caspase-3 activator that directly induces procaspase-3 cleavage. Anti-cancer compound. Apoptosis inducer. Antiproliferative, independent of immune system activation or function. Approved treatment for external genital warts caused by human papillomavirus infection. Group: Biochemicals. Alternative Names: 1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine; R-837; S-26308. Grades: Highly Purified. CAS No. 99011-02-6. Pack Sizes: 100mg, 250mg, 500mg, 1g. Molecular Formula: C14H16N4. US Biological Life Sciences. | Worldwide |
ixekizumab Quick inquiry Where to buy Suppliers range | Ixekizumab is a humanized monoclonal antibody that inhibits interleukin 17A (IL-17A). It was approved by FDA for the treatment of moderate to severe plaque psoriasis in adult patients. Uses: The treatment of plaque psoriasis. Synonyms: LY2439821; Taltz. Grades: ≥98%. CAS No. 1143503-69-8. Molecular formula: C6492H10012N1728O2028S46. Mole weight: 146200. | |
Lusvertikimab Quick inquiry Where to buy Suppliers range | Lusvertikimab is a humanized monoclonal antibody and interleukin-7 receptor antagonist. Synonyms: OSE-127. CAS No. 2375835-91-7. | |
LY 255283 Quick inquiry Where to buy Suppliers range | LY255283, a competitive leukotriene B4 receptor antagonist, is used in leukotriene receptor research along with other selective leukotriene receptor agonists and antagonist to identify and differentiate the physiological and cell signaling effects of the leukotriene B4 receptor on processes such as paclitaxel resistance in MCF-7/DOX breast cancer cells, monocyte-derived dendritic cell chemotaxis, and 5-lipoxygenase activity and interleukin-8 production in human neutrophils. LY255283 may be used to help verify that an observed process or cell event is leukotriene B4 receptor-dependent.Antagonists of the chemotactic and inflammatory lipoxygenase product leukotriene B4 (LTB4) have been potential drug development targets for several years.1,2 The tetrazole LY255283 is a competitive antagonist of the BLT2 receptor. It displaces radiolabeled LTB4 from guinea pig lung membrane, with an IC50 of about 100nM.3 LY255283 exhibits IC50 values of ~950nM and >10uM at human recombinant BLT2 and BLT1 receptors, respectively.4 LY255283 inhibits eosinophil chemotaxis by 80% at a concentration of 10uM, and inhibits the binding of radiolabeled LTB4 to eosinophil membranes with an IC50 of 260nM.1. Group: Biochemicals. Alternative Names: 1-[5-ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]-ethanone. Grades: Highly Purified. CAS No. 117690-79-6. Pack Sizes: 10mg, 25mg. Molecular Formula: C19H28N4O3, Molecular Weight: 360.5. US Biological Life Sciences. | Worldwide |
NF 546 Quick inquiry Where to buy Suppliers range | NF 546 is a P2Y11 agonist with pEC50 value of 6.27. It can stimulate release of interleukin-8 from human monocyte-derived dendritic cells. Synonyms: NF 546; NF546; NF-546; 4,4'-(Carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)carbonylimino))-bis(1,3-xylene-alpha,alpha'-diphosphonic acid tetrasodium salt. Grades: ≥95% by HPLC. CAS No. 1006028-37-0. Molecular formula: C47H44N6Na4O17P4. Mole weight: 1180.74. | |
Olokizumab Quick inquiry Where to buy Suppliers range | Olokizumab is a humanized monoclonal antibody that targets interleukin-6. Olokizumab is effective in the treatment of rheumatoid arthritis. Synonyms: CDP 6038; OKZ. CAS No. 1007223-17-7. | |
R-130823 Quick inquiry Where to buy Suppliers range | R-130823 is a highly selective inhibitor against mitogen-activated protein kinase p38alpha (IC50=22 nM). The release of tumor necrosis factor-alpha, interleukin-1beta, -6 and -8 was inhibited in lipopolysaccharide-stimulated human blood pretreated by R-130823, with IC50 values of 0.089, 0.066, 0.95 and 0.16 microM, respectively. Synonyms: R130823; R 130823; 2-(4-Fluorophenyl)-4-(1-phenethyl-1,2,3,6-tetrahydropyridin-4-yl)-3-(pyridin-4-yl)-1H-pyrrole. CAS No. 321344-32-5. Molecular formula: C28H26FN3. Mole weight: 423.53. | |
rec IL-2 (human) Quick inquiry Where to buy Suppliers range | Synonyms: rec Interleukin-2 (human). | |
reslizumab Quick inquiry Where to buy Suppliers range | Reslizumab is a humanized monoclonal antibody resistant to interleukin-5 (IL-5). It is approved for additional maintenance treatment of patients with severe asthma aged 18 years and older, and with an eosinophilic phenotype. Uses: The treatment of severe asthma. Synonyms: Cinqair. CAS No. 241473-69-8. | |
Ro 106-9920 Quick inquiry Where to buy Suppliers range | Ro 106-9920, a cell-permeable tetrazolopyridazine-phenylsulfoxide compound, is a small molecule inhibitor of NF-κB-dependent expression of TNF-α, interleukin-1β, and interleukin-6 (IC50 < 1 μM in human peripheral blood mononuclear cells). Synonyms: Ro 106-9920; Ro106-9920; Ro-106-9920; 6-(Phenylsulfinyl)tetrazolo[1,5-b]pyridazine. Grades: ≥99% by HPLC. CAS No. 62645-28-7. Molecular formula: C10H7N5OS. Mole weight: 245.26. | |
Satralizumab Quick inquiry Where to buy Suppliers range | Satralizumab is a humanized monoclonal antibody that inhibits interleukin-6 (IL-6) receptor. Satralizumab has been developed for the treatment of neuromyelitis optica spectrum disorder (NMOSD). Synonyms: Enspryng. CAS No. 1535963-91-7. | |
SB239063 Quick inquiry Where to buy Suppliers range | SB239063 is a potent p38MAPK inhibitor. SB 239063 had an IC(50) of 44 nM for inhibition of recombinant purified human p38alpha. In lipopolysaccharide-stimulated human peripheral blood monocytes, SB 239063 inhibited interleukin-1 and tumor necrosis factor-alpha production. SB 239063 may be useful for the treatment of asthma and other inflammatory disorders. Uses: Protein kinase inhibitors. Synonyms: SB-239063; SB 239063. Grades: 0.98. CAS No. 193551-21-2. Molecular formula: C20H21FN4O2. Mole weight: 368.412. | |
Secukinumab Quick inquiry Where to buy Suppliers range | Secukinumab is a recombinant human IgG1κ monoclonal antibody that specifically binds to and inhibits interleukin (IL)-17A. Secukinumab was developed by Novartis for the treatment of psoriasis, ankylosing spondylitis, and psoriatic arthritis. Uses: The treatment of psoriasis, ankylosing spondylitis, and psoriatic arthritis. Synonyms: Cosentyx. CAS No. 875356-43-7. Molecular formula: C6584H10134N1754O2042S44. Mole weight: 147944.39. | |
Sonelokimab Quick inquiry Where to buy Suppliers range | Sonelokimab is a novel trivalent nanobody comprised of monovalent camelid-derived nanobodies specific to human interleukin IL-17A, IL-17F, and human serum albumin. Sonelokimab has been used in the research of plaque psoriasis. Synonyms: ALX 0761; M 1095. CAS No. 1414386-05-2. | |
SR1001 Quick inquiry Where to buy Suppliers range | Retinoic-acid-receptor-related orphan receptors (ROR) α and γ play a key role in the development of T-helper cells that produce interleukin-17 (TH17 cells), a subset of CD4+ T-cells that contribute to the inflammatory process and have been implicated in the pathology of autoimmune diseases. SR 1001 is a synthetic ligand specific for RORα and RORγ (Kis = 172 and 111 nM, respectively) that functions as an inverse agonist at these receptors. SR 1001 has been shown to suppress IL-17 promoter driven transcriptional activity by inhibiting the interaction of co-activators such as TRAP220 nuclear receptor box 2 peptide (IC50 = 117 nM) and SRC2 with RORα and RORγ as well as by increasing the recruitment of corepressors such as NCoR. At 5 μM, SR 1001 inhibits TH17 cell differentiation and IL-17A secretion in cultured splenocytes and human PBMCs. A 25 mg/kg dose of SR 1001 twice/day delays the onset and the severity of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. Synonyms: SR 1001; SR-1001. Grades: >98%. CAS No. 1335106-03-0. Molecular formula: C15H13F6N3O4S2. Mole weight: 477.4. | |
Suplatast Tosylate Quick inquiry Where to buy Suppliers range | Suplatast Tosylate is an antiallergic drug. Suplatast Tosylate inhibits antigen-induced histamine release from mast cells as well as IgE antibody formation. Suplatast Tosylate suppresses interleukin (IL)-4 release from T cells, however in human peripheral basophils, Suplatast Tosylate inhibited the antigen-induced release of IL-13 but not IL-4. Group: Biochemicals. Alternative Names: [3- [ [4- (3-ethoxy-2-hydroxypropoxy) phenyl] amino] -3-oxopropyl] dimethylsulfonium 4-Methyl Benzene sulfonate; (±) - [2- [4- (3-Ethoxy-2-hydroxypropoxy) phenylcarbamoyl] ethyl] dimethylsulfonium p-toluenesulfonate; IPD 1151T; Suplatast tosilate. Grades: Highly Purified. CAS No. 94055-76-2. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
Suramin Hexasodium Salt (Germanin, NSC 34936, SK 24728) Quick inquiry Where to buy Suppliers range | Sodium salt of Suramin, a hepatitis C virus NS3 helicase inhibitor. Also used in the treatment of arthritis due to problematic collagen.A P2x and P2y purinergic receptor antagonist that displays antitumor, antiangiogenic and antiparasitic activities. Inhibits sirtuin 1, sirtuin 5 and topoisomerase II. Inhibits the cell surface binding of various growth factors including PDGF, EGF, FGFa and FGFb. Blocks association of G protein alpha and b/g-subunits. Potent competitive inhibitor of reverse transcriptase and protects T lymphocytes against in vitro human immunodeficiency virus infection.Potent ATPase inhibitor. Potent competitive inhibitor of reverse transcriptase. Shows anti-HIV activity. Anticancer compound. Protein kinase C (PKC) inhibitor. Potent inhibitor of melanoma heparanase and tumor cell metastasis. Non-specific growth factors inhibitor (including PDGF, EGF, aFGF and bFGF). TGF-beta1 inhibitor. Topoisomerase I and II inhibitor. Interleukin-1 (IL-1) inhibitor. Interleukin-4 (IL-4) inhibitor. G protein inhibitor. P2X and P2Y purinergic receptor antagonist. Antiangiogenic. Potent VEGF inhibitor. Telomerase inhibitor. Shows adjuvant properties. Regulates ryanodine receptor. Direct adenylyl cyclase inhibitor. Protein synthesis inhibitor. SIRT1 (Sirtuin 1) and SIRT5 (Sirtuin 5) inhibitor. Immunosuppressive. Antifibrotic agent. Antiparasitic. Antiprotozoal. Athelmintic. Group: Biochemicals. Alternative Names: 8, 8'-[Carbonylbis[imino-3, 1-phenylenecarbonylimino (4-methyl-3, 1-phenylene) carbonylimino]]bis-1, 3, 5-naphthalenetrisulfonic Acid Sodium Salt (1:6); 8, 8'-[Carbonylbis[imino-3, 1-phenylenecarbonylimino (4-methyl-3, 1-phenylene) carbonylimino]]bis-1, 3, 5-naphthalenetrisulfonic Acid Hexasodium Salt; 8, 8'-[Ureylenebis[m-phenylenecarbonylimino (4-methyl-m-phenylene) carbonylimino]]di-1, 3, 5-naphthalenetrisulfonic Acid Hexasodium Salt; 309F; 8,8'-[Ureylenebis[m-phenylene carbonylimino (4-methyl-m-phenylene) carbonylimino]]di (1, 3, 5-naphthalenetrisulfonic Acid) Hexasodium Salt; Antrypol; BAY 205; Bayer 205; CI 1003; Fourneau 309; Germanin; Germanin (pharmaceutical); Hexasodium Sym.-bis(m-aminobenzoyl)-m-amino-p-methylbenzoyl-1-naphthylamino-4,6,8-trisulfonate) Carbamide; Moranyl; NF 060; Naganin; Naganine; Naphuride; Naphuride sodium; Sodium Suramin; Suramin Hexasodium; Suramin Sodium; Suramine Sodium. Grades: Highly Purified. CAS No. 129-46-4. Pack Sizes: 50mg, 100mg, 250mg. Molecular Formula: C??H??N?Na?O??S?, Molecular Weight: 1429.17. US Biological Life Sciences. | Worldwide |
tocilizumab Quick inquiry Where to buy Suppliers range | Tocilizumab is a humanized monoclonal antibody resistant against the interleukin-6 receptor (IL-6R). It is an immunosuppressive agent commonly used for the treatment of rheumatoid arthritis (RA) and systemic juvenile idiopathic arthritis. Actemra (tocilizumab) 162 mg syringe for subcutaneous injection and Actemra 162 mg auto-injector for subcutaneous injection was approved in Japan for the treatment of Takayasu arteritis (TAK) and giant cell arteritis (GCA), as well as its intravenous injection was approved by FDA for severe cytokine release syndrome (CRS). Uses: The treatment of rheumatoid arthritis (ra), systemic juvenile idiopathic arthritis, takayasu arteritis (tak), giant cell arteritis (gca), severe cytokine release syndrome (crs), etc. Synonyms: Anti-Human IL6R, Humanized Antibody; Actemra; R 1569; RoActemra; Atlizumab; Actemra 200; R1569; R-1569. Grades: ≥95%. CAS No. 375823-41-9. Molecular formula: C6428H9976N1720O2018S42. Mole weight: 145000. |