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| Product | Description | |
|---|---|---|
| Irinotecan | Irinotecan. CAS No. 97682-44-5. Product ID: 2-08290. Molecular formula: C33H38N4O6. Mole weight: 586.7. Purity: 98.5% (HPLC). |  |
| Irinotecan | Irinotecan. Group: Biochemicals. Grades: Highly Purified. CAS No. 97682-44-5. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C33H38N4O6. US Biological Life Sciences. |  Worldwide |
| Irinotecan | Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (+)-Irinotecan; CPT-11; VAL-413(free base). CAS No. 97682-44-5. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-16562. |  |
| Irinotecan | Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively. It is used for the treatment of colon and rectum cancers. It binds to topoisomerase I-DNA complex, preventing religation of the DNA strand and leading to double-strand DNA breakage and cell death. Uses: Topoisomerase i inhibitors. Synonyms: Irinophore C; Irinotecan lactone; Irinotecan mylan; Onivyde; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline, [1,4'-Bipiperidine]-1'-carboxylic Acid deriv.; (S)-[1,4'-Bipiperidine]-1'-carboxylic Acid 4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl Ester; Camptosar; Irinotecanum; CPT-11; CPT 11; CPT11; (+)-Irinotecan. Grades: ≥98%. CAS No. 97682-44-5. Molecular formula: C33H38N4O6. Mole weight: 586.68. |  |
| Irinotecan 11-Desethyl Impurity | Cas No. 103816-16-6. | |
| Irinotecan 8-Ethyl Impurity | Cas No. 947687-02-7. | |
| Irinotecan Carboxylate Sodium Salt | Carboxylate form of Irinotecan. Group: Biochemicals. Alternative Names: (αS)-lizino[1,2-b]quinoline-7-acetic Acid Sodium Salt. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Irinotecan-d10 | Irinotecan-d 10 is a deuterium labeled Irinotecan ((+)-Irinotecan). Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex[1]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: (+)-Irinotecan-d10; CPT-11-d10; VAL-413-d10. CAS No. 718613-28-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-16562S. | |
| Irinotecan-d10 hydrochloride | Irinotecan-d 10 (hydrochloride) is the deuterium labeled Irinotecan. Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex[1][2]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 718612-62-5. Pack Sizes: 1 mg. Product ID: HY-16562S1. | |
| Irinotecan-d10 Hydrochloride | Deuterated Irinotecan, a DNA topoisomerase inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Irinotecan EP Impurity A | Irinotecan EP Impurity A. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-4-ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate. CAS No. 103816-16-6. Molecular formula: C31H34N4O6. Mole weight: 558.62. Catalog: APB103816166. |  |
| Irinotecan EP Impurity H | An impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer. Synonyms: (S)-11-Ethyl-4-hydroxy-4-methyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate; 4-methyl irinotecan analogue. Molecular formula: C32H36N4O6. Mole weight: 572.65. | |
| Irinotecan EP Impurity K | An impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer. Synonyms: (4S)-4-ethyl-4-hydroxy-11-(1-hydroxypropyl)-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino-[1,2-b]quinolin-9-yl 1,4'-bipiperidine-1'-carboxylate. Molecular formula: C34H40N4O7. Mole weight: 616.70. | |
| Irinotecan EP Impurity L | An impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer. Synonyms: (R)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate; irinotecan enantiomer. CAS No. 1255644-71-3. Molecular formula: C33H38N4O6. Mole weight: 586.68. | |
| Irinotecan HCl | Cas No. 100286-90-6. | |
| Irinotecan hydrochloride | Irinotecan hydrochloride. Group: Biochemicals. Alternative Names: [1,4'-Bipiperidine]-1'-carboxylic Acid (4S)-4,11-Diethyl-3,4,12,14- tetrahydro-4-hydroxy-3, 14-dioxo-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinolin-9-yl Ester Hydrochloride Trihydrate; Campto; CPT11; Irinotecan hydrochloride trihydrate. Grades: Highly Purified. CAS No. 100286-90-6,136572-09-3. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. Molecular Formula: C33H38N4O6·HCl. US Biological Life Sciences. | Worldwide |
| Irinotecan hydrochloride | Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer [1]. Uses: Scientific research. Group: Natural products. Alternative Names: (+)-Irinotecan hydrochloride; CPT-11 hydrochloride; VAL-413. CAS No. 100286-90-6. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-16562A. | |
| Irinotecan hydrochloride | Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Camptothecin II. Product Category: Inhibitors. CAS No. 100286-90-6. Mole weight: 623.1. Purity: 95%+. Product ID: ACM100286906. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Irinotecan hydrochloride | topoisomerase inhibitor. Group: Fluorescence/luminescence spectroscopy. | |
| Irinotecan hydrochloride | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Irinotecan Hydrochloride | (1,4'-bipiperidine)-1'-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy- 3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-9-yl ester, mono; trihydrate. CAS No. 136572-09-3. Product ID: 8-04245. Molecular formula: C33H38N4O6.HCl.3H2O. Mole weight: 677.2. Properties: | |
| Irinotecan Hydrochloride | (+)-(4S)-4,11-diethyl-4-hydroxy-9 [(4-piperidine) carbonyl]-1H pyrano [3,4,6,7] indolyzine [1,2b] quinoline-3,14-(4h-12h)-diketone hydrochloride trihydrate. CAS No. 100286-90-6. Product ID: 8-04905. Molecular formula: C33H38N4O6 · HCl. Mole weight: 677.19. MFCD No. MFCD01862255. | |
| Irinotecan, Hydrochloride Salt, Trihydrate ([1,4-Bipiperidine]-1-carboxylic Acid (S)-4, 11-diethyl-3, 4, 12, 14-tetrahydro-4-hydroxy-3, 14-dioxo-1H-pyrano[3, 4, 6, 7]indolizino[1, 2-b]quinolin-9-yl Ester, HCl Trihydrate) | Irinotecan (CPT-11) is a topoisomerase I inhibitor. It is a semisynthetic analog of the natural alkaloid camptothecin and has an active metabolite SN-38 (7-Ethyl-10-hydroxycamptothecin). During the S phase of the cell cycle, camptothecins selectively bind to and stabilize topoisomerase I-DNA complexes, inhibiting religation, causing the accumulation of topoisomerase I-mediated single-strand DNA breaks in the DNA, and producing irreversible double-strand DNA breaks that lead to cell death. Group: Biochemicals. Grades: Highly Purified. CAS No. 136572-09-3. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Irinotecan hydrochloride trihydrate | Irinotecan hydrochloride trihydrate ((+)-Irinotecan hydrochloride trihydrate) is a topoisomerase I inhibitor with antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (+)-Irinotecan hydrochloride trihydrate; CPT-11 hydrochloride trihydrate. CAS No. 136572-09-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-16568. | |
| Irinotecan hydrochloride trihydrate | Irinotecan hydrochloride trihydrate ((+)-Irinotecan hydrochloride trihydrate) is a topoisomerase I inhibitor with antitumor activity. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin hydrochloride trihydrate. Product Category: Inhibitors. CAS No. 136572-09-3. Mole weight: 677.2. Purity: 98%+. Product ID: ACM136572093. Alfa Chemistry ISO 9001:2015 Certified. | |
| Irinotecan Hydrochloride trihydrate | Irinotecan Hydrochloride trihydrate. CAS No. 136572-09-3. Product ID: 2-08291. Molecular formula: C33H45ClN4O9. Mole weight: 677.2. | |
| Irinotecan Hydrochloride Trihydrate | The hydrochloride salt of Irinotecan. Irinotecan is a prodrug that can be activated to 7-ethyl-10-hydroxy-camptothecin (SN-38) by the carboxylesterase-converting enzyme. SN-38 inhibits topoisomerase I to suppress DNA replication and promote cell death. Synonyms: CPT-11 HCl Trihydrate; CPT 11 HCl Trihydrate; CPT11 HCl Trihydrate; Irinotecan Hcl Trihydrate; UNII-042LAQ1IIS. Grades: >98%. CAS No. 136572-09-3. Molecular formula: C33H38N4O6.HCl.3H2O. Mole weight: 677.18. | |
| Irinotecan, Hydrochloride, Trihydrate ([1,4-Bipiperidine]-1-carboxylic Acid (S)-4, 11-diethyl-3, 4, 12, 14-tetrahydro-4-hydroxy-3, 14-dioxo-1H-pyrano[3, 4, 6, 7]indolizino[1, 2-b]quinolin-9-yl Ester, HCl Trihydrate) | A DNA topoisomerase inhibitor. Group: Biochemicals. Alternative Names: [1,4-Bipiperidine]-1-carboxylic acid (S)-4, 11-diethyl-3, 4, 12, 14-tetrahydro-4-hydroxy-3, 14-dioxo-1H-pyrano[3, 4, 6, 7]indolizino[1, 2-b]quinolin-9-yl ester, Hcl Trihydrate. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Irinotecan Impurity 17 | Irinotecan Impurity 17. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1332610-75-9. Molecular formula: C19H14N2O4. Mole weight: 334.33. Catalog: APB1332610759. | |
| Irinotecan Impurity 18 | Irinotecan Impurity 18. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1255644-71-3. Molecular formula: C33H38N4O6. Mole weight: 586.69. Catalog: APB1255644713. | |
| Irinotecan Impurity 2 | A lactone impurity of Irinotecan. Synonyms: [1,4'-Bipiperidine]-1'-carboxylic Acid 3,10-Diethyl-11,13-dihydro-1,13-dioxo-1H,3H- furo[3',4':6,7]indolizino[1,2-b]quinolin-8-yl Ester. Grades: > 95%. CAS No. 143490-53-3. Molecular formula: C32H36N4O5. Mole weight: 556.67. | |
| Irinotecan Impurity 25 | Irinotecan Impurity 25. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1026078-50-1. Molecular formula: C11H20N2O2. Mole weight: 212.29. Catalog: APB1026078501. | |
| Irinotecan Impurity 33 | Irinotecan Impurity 33. Uses: For analytical and research use. Group: Impurity standards. CAS No. 14154-82-6. Molecular formula: C13H26Cl2N2O2. Mole weight: 313.26. Catalog: APB14154826. | |
| Irinotecan Impurity 35 (Sodium Salt) | Irinotecan Impurity 35 (Sodium Salt). Uses: For analytical and research use. Group: Impurity standards. CAS No. 1329502-92-2. Molecular formula: C33H39N4NaO7. Mole weight: 626.69. Catalog: APB1329502922. | |
| Irinotecan Impurity 9 | Irinotecan Impurity 9. Uses: For analytical and research use. Group: Impurity standards. CAS No. 124622-81-7. Molecular formula: C24H24N2O4. Mole weight: 404.47. Catalog: APB124622817. | |
| Irinotecan Impurity M | Irinotecan Impurity M. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (4S)-4,11-diethyl-4,12-dihydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate. CAS No. 185336-12-3. Molecular formula: C33H38N4O7. Mole weight: 602.68. Catalog: APB185336123. | |
| Irinotecan Liposome | Irinotecan, a camptothecin derivative, is a topoisomerase I inhibitor that inhibits cell growth and has broad-spectrum antitumor effects. This product is a PEGylated pre-formulated liposome with irinotecan. It is only for research purposes and for the injection to laboratory animals. Group: Drug-loaded liposome. Categories: liposomes, niosomes, ethosomes, and transfersomes. |  |
| Irinotecan Related Compound A | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Irinotecan Related Compound B | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Irinotecan Related Compound C | An impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer. Synonyms: 11-Ethyl-4-hydroxy-4-methyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl (1,4'-bipiperidine)-1'-carboxylate hydrochloride; USP Irinotecan Related Compound C. Molecular formula: C32H37ClN4O6. Mole weight: 609.11. | |
| Irinotecan Related Compound C | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Irinotecan Related Compound D | An impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer. Synonyms: (R)-9-[(1,4'-Bipiperidine)-1'-carbonyloxy]-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1Hpyrano[3',4':6,7]indolizino[1,2-b]quinoline hydrochloride trihydrate; USP Irinotecan Related Compound D. Molecular formula: C33H45ClN4O9. Mole weight: 677.18. | |
| Irinotecan Related Compound D | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Irinotecan Related Compound E | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Irinotecan Related Compound(RPR 121056) | impurity of Irinotecan. Synonyms: 7-Ethyl-10-(4-N-aminopentanoic acid)-1-piperidino)carbonyloxycamptothecin. Grades: > 95%. CAS No. 181467-56-1. Molecular formula: C33H38N4O8. Mole weight: 618.69. | |
| 11-Desethyl Irinotecan | 11-Desethyl Irinotecan is an impurity of the DNA topoisomerase inhibitor Irinotecan (I767500). Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-3, 4, 12, 14-tetrahydro-4-hydroxy-3, 14-dioxo-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinolin-9-yl Ester [1,4'-Bipiperidine]-1'-carboxylic Acid; 1H-Pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline, [1,4'-Bipiperidine]-1'-carboxylic Acid deriv.; 10- [4- (1-Piperidino) -1-piperidinocarbonyloxy] camptothecin. Grades: Highly Purified. CAS No. 103816-16-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 11-Desethyl Irinotecan-d10 | 11-Desethyl Irinotecan-d10. Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-3, 4, 12, 14-tetrahydro-4-hydroxy-3, 14-dioxo-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinolin-9-yl Ester [1,4'-Bipiperidine]-1'-carboxylic Acid-d10; 1H-Pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline, [1,4'-Bipiperidine]-1'-carboxylic Acid deriv.-d10; 10- [4- (1-Piperidino) -1-piperidinocarbonyloxy] camptothecin-d10. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C31H24D10N4O6, Molecular Weight: 568.69. US Biological Life Sciences. | Worldwide |
| 12-Hydroxy irinotecan | 12-Hydroxy irinotecan. Group: Biochemicals. Alternative Names: [1,4'-Bipiperidine]-1'-carboxylic acid (4S)-4,11-diethyl-3,4,12,14-tetrahydro- 4, 12-dihydroxy-3, 14-dioxo-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinolin-9-yl ester; (4S) -4, 11-Diethyl-4, 12-dihydroxy-9-[ (4-piperidinopiperidino) carbonyloxy]-1H-pyrano[3', 4': 6, 7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H) -dione; RPR 112524. Grades: Highly Purified. CAS No. 185336-12-3. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C33H38N4O7. US Biological Life Sciences. | Worldwide |
| Etirinotecan pegol | Etirinotecan pegol, also know as pegylated irinotecan, NKTR102, is a formulation of polyethylene glycol (PEG)-encapsulated irinotecan with antineoplastic activity. The prodrug irinotecan, a semisynthetic derivative of camptothecin, is converted to the biologically active metabolite 7-ethyl-10-hydroxy-camptothecin by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, 7-ethyl-10-hydroxy-camptothecin inhibits topoisomerase I activity by stabilizing the cleavable complex of topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptosis. Pegylation provides improved drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic effects while lowering the toxicity profile. Synonyms: NKTR102; NKTR 102; NKTR-102; pegylated irinotecan NKTR 102; Etirinotecan pegol. CAS No. 1193151-09-5. Molecular formula: C161H196Cl4N20O40. Mole weight: 3193.24. | |
| 10-O-Acetyl SN-38 | Protected Irinotecan metabolite. Group: Biochemicals. Alternative Names: 10-Acetyloxy-7-ethylcamptothecin; 10-Hydroxy-7-ethylcamptothecin 10-Acetate; (4S)-9-(Acetyloxy)-4, 11-diethyl-4-hydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. CAS No. 946821-59-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 10-O-Acetyl SN-38-d3 | 10-O-Acetyl SN-38-d3 is the isotope labelled protected metabolite of Irinotecan (I767500), an DNA topoisomerase inhibitor. Group: Biochemicals. Alternative Names: 10-Acetyloxy-7-ethylcamptothecin-d3; (4S)-9-(Acetyloxy)-4, 11-diethyl-4-hydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione-d3; 10-Hydroxy-7-ethylcamptothecin 10-Acetate-d3. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| 10-O-Methoxymethyl SN-38 | Protected Irinotecan metabolite. Group: Biochemicals. Alternative Names: 7-Ethyl-10-O-methoxymethyl-10-hydroxycamptothecin; 10-Hydroxy-10-O-methoxymethyl-7-ethylcamptothecin; 10-MOM SN-38; (4S)-4, 11-Diethyl-4-hydroxy-9-(methoxymethoxy)-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. CAS No. 1246815-54-2. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| 1-(2-Amino-5-hydroxyphenyl)propan-1-one | 1-(2-Amino-5-hydroxyphenyl)propan-1-one is a useful synthetic intermediate. It is used in the asymmetrical synthesis of (S)-4-ethyl-6,7,8,10- tetrahydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione, a key intermediate for synthesis of irinotecan and other camptothecin analogs. It is also used in the synthesis of E-?ring-?modified (RS)?-?camptothecin analogs as antitumor agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 35364-15-9. Pack Sizes: 250mg, 2.5g. Molecular Formula: C9H11NO2. US Biological Life Sciences. | Worldwide |
| 1,2-Distearoyl-sn-glycero-3-phosphorylglycerol | 1,2-Distearoyl-sn-glycero-3-phosphorylglycerol is used as a component of a loposomal delivery system that coordinates the release of irinotecan and floxuridine in vivo. It is also used to encapsulate anthracyclines and deliver them to tumors. Group: Biochemicals. Grades: Highly Purified. CAS No. 4537-78-4. Pack Sizes: 10mg, 100mg. Molecular Formula: C42H83O10P, Molecular Weight: 779.08. US Biological Life Sciences. | Worldwide |
| 20-Desethyl-20-methyl-10-hydroxy-7-ethylcamptothecin | 20-Desethyl-20-methyl-10-hydroxy-7-ethylcamptothecin is an intermediate in the synthesis of Irinotecan Hydrochloride (I767500), a DNA topoisomerase inhibitor and also a derivative of Camptothecin (C175145), an antitumor alkaloid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C21H18N2O5. US Biological Life Sciences. | Worldwide |
| 2-Hydroxy-2- (6'- (hydroxymethyl) -5'-oxo-3', 5', 8', 8a'-tetrahydro-2'H-spiro[[1, 3]dioxolane-2, 1'-indolizin]-7'-yl) -N- ( (S) -1-phenylethyl) propanamide | 2-Hydroxy-2- (6'- (hydroxymethyl) -5'-oxo-3', 5', 8', 8a'-tetrahydro-2'H-spiro[[1, 3]dioxolane-2, 1'-indolizin]-7'-yl) -N- ( (S) -1-phenylethyl) propanamide is an intermediate in the synthesis of Irinotecan Hydrochloride (I767500), a DNA topoisomerase inhibitor and also a derivative of Camptothecin (C175145), an antitumor alkaloid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C22H28N2O6. US Biological Life Sciences. | Worldwide |
| 7-Ethyl -10- (4-amino-1-piperidino) carbonyl oxycamptothecin | A major metabolite of Irinotecan. Group: Biochemicals. Alternative Names: 4-Amino-(4S)-4, 11-diethyl-3, 4, 12, 14-tetrahydro-4-hydroxy-3, 14-dioxo-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinolin-9-yl 1-Piperidinecarboxylic Acid Ester; RPR 132595A; NPC (metabolite). Grades: Highly Purified. CAS No. 185304-42-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 7-Ethyl -10- (4-amino-1-piperidino) carbonyl oxycamptothecin-d3 | A major labeled metabolite of Irinotecan. Group: Biochemicals. Alternative Names: 4-Amino-(4S)-4-Ethyl-11-(ethyl-d3)-3, 4, 12, 14-tetrahydro-4-hydroxy-3, 14-dioxo-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinolin-9-yl. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 7-Ethyl-10-(4-N-aminopentanoic acid) -1-piperidino) carbonyl oxycamptothecin | A major metabolite of Irinotecan. Group: Biochemicals. Alternative Names: 4-[(4-Carboxybutyl)amino]-1-piperidinecarboxylic Acid. Grades: Highly Purified. CAS No. 181467-56-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 7-Ethyl-10-(4-N-aminopentanoic acid) -1-piperidino) carbonyl oxycamptothecin-d3 | A major labeled metabolite of Irinotecan. Group: Biochemicals. Alternative Names: 4-[(4-Carboxybutyl)amino]-1-piperidinecarboxylic Acid. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 7-Ethyl-10-(4-N-aminopentanoic acid) -1-piperidino) carbonyl oxycamptothecin Hydrochloride | A major metabolite of Irinotecan. Group: Biochemicals. Alternative Names: 4-[(4-Carboxybutyl)amino]-1-piperidinecarboxylic Acid. Grades: Highly Purified. CAS No. 181629-47-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 7-Ethyl Camptothecin | The main reasons for the superior antitumor activity of 7-Ethylcamptothecin compared with CPT are as follows: (a) 7-Ethylcamptothecin had a stronger growth-inhibiting activity against tumor cells, and (b) 7-Ethylcamptothecin remained in the intestinal tract for a longer time and in higher amounts when administered in vivo. 7-Ethyl Camptothecin is a natural compound found in the barks of Camptotheca acuminata Decne, it can be used as a cosmetics material. Synonyms: (S)-4,11-Diethyl-4-hydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione; 7-ethylcamptothecin; (4S)-4,11-diethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; Irinotecan EP Impurity F. Grades: >98%. CAS No. 78287-27-1. Molecular formula: C22H20N2O4. Mole weight: 376.42. | |
| AZ31 | AZ31 is a potent and highly selective ATM inhibitor with an IC50 of <1.2 nM. It displays excellent selectivity against a panel of kinases including ATR, DNAPK, mTOR, PI3Kα, PI3Kβ, PI3Kγ, GSK3β and KDR. AZ 31 also shows significant tumor growth reduction in the SW620 xenograft model combined with irinotecan. Synonyms: AZ 31; AZ-31;(S)-6-(6-(methoxymethyl)pyridin-3-yl)-4-((1-(tetrahydro-2H-pyran-4-yl)ethyl)amino)quinoline-3-carboxamide. Grades: ≥98%. CAS No. 2088113-98-6. Molecular formula: C24H28N4O3. Mole weight: 420.50. | |
| BCRP Inhibitor IV, YHO-13351 (Diethylaminoacetic Acid, 1-(5-((Z)-2-cyano-2- (3, 4-dimethoxyphenyl) vinyl) thiophen-2-yl) piperidin-4-yl ester, Methanesulfonate) | An in vivo bioavailable (~87%; t1/2 <5 mins. during p.o. and i.v. administration) and highly water soluble (>100mg/ml) diethylaminoacetate prodrug of YHO-13177 that reverses BCRP-mediated irinotecan resistance in P388/BCRP and HCT116/BCRP xenograft mouse models, and suppresses tumor growth and significantly enhances the survival (100 or 200mg/kg, i.p.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Diflomotecan | Diflomotecan is an E-ring modified camptothecin analogue, which possesses greater lactone stability in plasma compared with other topoisomerase I inhibitors. Diflomotecan is also a 10,11-difluoro-homocamptothecin, represents a new promising class of topoisomerase I inhibitors with enhanced plasma stability and superior preclinical anti-tumour activity as compared to the established camptothecins, irinotecan and topotecan. Diflomotecan was the first homocamptothecin to enter clinical studies. Phase I data are summarized for both the intravenous and oral schedules. The toxicity is primarily haematological while no severe gastrointestinal toxicity has been observed in contrast to other topoisomerase I inhibitors. Diflomotecan has a high oral bioavailability (72 - 95%) and the oral day 1 - 5 every 3 weeks regimen is recommended for Phase II testing because it is relatively well tolerated, convenient and mimics protracted exposure. Synonyms: BN 80915; 3H,15H-Oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione, 5-ethyl-9,10-difluoro-1,4,5,13-tetrahydro-5-hydroxy-, (5R)-; (5R)-5-Ethyl-9,10-difluoro-1,4,5,13-tetrahydro-5-hydroxy-3H,15H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione; (R)-5-Ethyl-9, 10-difluoro-5-hydroxy-4, 5-dihydrooxepino[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 15(1H, 13H)-dione. Grades: ≥95%. CAS No. 220997-97-7. Molecular formula: C21H16F2N2O4. Mole weight: 398.36. | |
| (S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione | (S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione is a key intermediate in the synthesis of Exatecan, Irinotecan and Camptothecin analogs. Synonyms: (4S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione; (S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione; 1H-Pyrano[3,4-f]indolizine-3,6,10(4H)-trione, 4-ethyl-7,8-dihydro-4-hydroxy-, (4S)-. Grades: ≥95%. CAS No. 110351-94-5. Molecular formula: C13H13NO5. Mole weight: 263.25. | |
| SN-38 | SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC 50 s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254) [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: 7-Ethyl-10-hydroxycamptothecin. CAS No. 86639-52-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13704. | |
| SN-38. (7-Ethyl-10-hydroxycamptothecin) | A metabolite of Irinotecan, a DNA topoisomerase inhibitor. Group: Biochemicals. Alternative Names: 7-Ethyl-10-hydroxycamptothecin. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| SN-38 glucuronide | SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SN-38G. CAS No. 121080-63-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-126373. | |
| SN-38 Glucuronide | A metabolite of Irinotecan. Synonyms: 7-Ethyl-10-hydroxy-camptothecin-10-O-b-Dglucuronide; (4S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl b-D-glucopyranosiduronic acid. Grades: > 95%. CAS No. 121080-63-5. Molecular formula: C28H28N2O11. Mole weight: 568.53. | |
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