Isocitrate Suppliers USA
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Product | Description | |
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DL-Isocitric acid trisodium salt hydrate Quick inquiry Where to buy Suppliers range | ≥93%. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 1637-73-6 (anhydrous). Pack Sizes: 1G, 5G, 10G, 25G, 100G. Mole weight: 258.07 (anhydrous basis). Catalog: ALP1637736. Assay: ≥93%. | |
Ds(+)-threo-Isocitric acid trisodium salt Quick inquiry Where to buy Suppliers range | Anticoagulant that retains platelets functionality. Buffers Ca2+ activity in physiological range (~1mM). Bypasses the metabolic blockade, may permit heme biosynthesis but does not suffice to reverse the iron-restriction response. Stabilizes the iron-sulfur cluster and is predicted to restore aconitase to its 'high iron' conformation and thereby dissociates the PKC-associated signaling complexes whose hyperactivation impairs Epo responsiveness. Binds IDH (isocitrate dehydrogenase), an excellent candidate for participating, along with aconitase and PKC, in an iron restriction signalosome. Contributes to heme biosynthesis which may account for its greater potency in restoring erythroid differentiation. Group: Biochemicals. Alternative Names: (1R,2S)-1-Hydroxy-1,2,3-propanetricarboxylic acid; (2R,3S)-Isocitric acid trisodium salt. Grades: Highly Purified. CAS No. 903507-52-8. Pack Sizes: 25mg, 100mg. Molecular Formula: C6H5O7 3Na, Molecular Weight: 258.1. US Biological Life Sciences. | Worldwide |
Isocitric acid trisodium salt Quick inquiry Where to buy Suppliers range | Isocitric acid trisodium salt (CAS# 1637-73-6 ) is a useful research chemical. Synonyms: Sodium isocitrate; DL-Isocitric acid trisodium salt. Grades: 95 %. CAS No. 1637-73-6. Molecular formula: C6H5Na3O7. Mole weight: 258.07. | |
Trisodium Isocitric Acid Quick inquiry Where to buy Suppliers range | DL-iso-citric acid trisodium salt is the trisodium salt of isocitric acid. Isocitric acid is the isomer of citric acid. The isocitric acid is an essential substrate in the central metabolic pathway, citric acid cycle (TCA cycle) inside organisms. Since it is an organic acid found in most fruit juices, it is commonly used as a marker to evaluate the authenticity and quality of fruit products, most often citrus juices in food industry. Group: Biochemicals. Alternative Names: Sodium isocitrate; 3-Carboxy-2,3-dideoxypentaric Acid Trisodium Salt. Grades: Highly Purified. CAS No. 1637-73-6. Pack Sizes: 1g. Molecular Formula: C6H8Na3O7, Molecular Weight: 258.07. US Biological Life Sciences. | Worldwide |
2-Aminotetraline-2-carboxylic acid Quick inquiry Where to buy Suppliers range | 2-Aminotetraline-2-carboxylic acid is a potent and selective IDH1 (isocitrate dehydrogenase 1) mutant inhibitor for the treatment of acute myeloid leukemia. Synonyms: Atc-OH; 2-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid; 2-Aminotetralin-2-carboxylic acid; D,L-2-Aminotetralin-2-carboxylic acid; 2-AMINOTETRALINE-2-CARBOXYLIC ACID; 2-Amino-1,2,3,4-tetrahydro-2-naphthalenecarboxylicacid; 2-amino-3,4-dihydro-1H-naphthalene-2-carboxylic acid; (R)-2-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid; (+/-)-2-Amino-1,2,3,4-tetrahydro-2-naphthoic acid; GSK 321; Atc OH. Grades: ≥ 98% (HPLC). CAS No. 6331-63-1. Molecular formula: C11H13NO2. Mole weight: 191.22. | |
2-Bromopropanedioic Acid Quick inquiry Where to buy Suppliers range | 2-Bromopropanedioic Acid is an analog of the competitive inhibitor, malonate. Inhibitory activity towards Isocitrate lyase. Group: Biochemicals. Alternative Names: Bromomalonic Acid; Monobromomalonic Acid. Grades: Highly Purified. CAS No. 600-31-7. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
(2R,3S)-3-Methylmalic Acid Quick inquiry Where to buy Suppliers range | (2R,3S)-3-Methylmalic Acid is used as one of determinants of performance in isocitrate dehydrogenase of Escherichia coli. Group: Biochemicals. Grades: Highly Purified. CAS No. 152204-30-3. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C5H8O5, Molecular Weight: 148.11. US Biological Life Sciences. | Worldwide |
AG-120 Quick inquiry Where to buy Suppliers range | AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Synonyms: (2S)-N-(1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide; AG-120 (racemic); AG120; AG 120; AG-120; RG-120 (racemic); RG-120, RG 120; Ivosidenib (racemic). Grades: 98%. CAS No. 1448346-63-1. Molecular formula: C28H22ClF3N6O3. Mole weight: 582.97. | |
BAY 1436032 Quick inquiry Where to buy Suppliers range | BAY-1436032 is a highly selective, potent and orally available inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). It is a double-digit nanomolar and selective pan-inhibitor of the enzymatic activity of various IDH1-R132X mutants in vitro and displays potent inhibition of 2-HG release (nanomolar range) in patient derived and engineered cell lines expressing different IDH1 mutants. BAY 1436032 strongly reduces 2-HG (2-hydroxyglutarate) levels in cells carrying IDH1-R132H, -R132C, -R132G, -R132S and -R132L mutations. BAY 1436032 showed a favourable selectivity profile against wtIDH1/2 and a large panel of off-targets in vitro. Synonyms: 3-(2-[[4-(Trifluoromethoxy)phenyl]amino]-1-[(1R,5R)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)propanoic Acid; BAY-1436032. Grades: ≥98%. CAS No. 1803274-65-8. Molecular formula: C26H30F3N3O3. Mole weight: 489.53. | |
Citreoviridin (80%, Contain Isocitreoviridin) Quick inquiry Where to buy Suppliers range | Citreoviridin (80%, Contain Isocitreoviridin). Uses: For analytical and research use. Group: Mycotoxins; Mycotoxins; Mycotoxins; Chiral Molecules. CAS No. 25425-12-1. Molecular formula: C23H30O6. Mole weight: 402.48. Catalog: APS25425121. Format: Neat. | |
DL-threo-2-methylisocitrate Quick inquiry Where to buy Suppliers range | DL-threo-2-methylisocitrate is a substrate of isocitrate lyase 1(ICL1). Synonyms: DL-threo-2-methylisocitrate; 71183-66-9; alpha-methylisocitric acid; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylic acid; methylisocitrate; Methylisocitric acid; threo-Pentaric acid, 3-carboxy-2,3-dideoxy-4-C-methyl-; SCHEMBL1533821; CHEBI:15607; DTXSID301209270; LMFA01050444; AKOS030526883; DB04072; HY-16581; C04593; Q27098140; 3-carboxy-2,3-dideoxy-4-C-methyl-L-threo-pentaric acid; rel-(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylic acid; rel-(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylicacid. Grades: >98%. CAS No. 71183-66-9. Molecular formula: C14H20O14. Mole weight: 412.3. | |
Enasidenib Quick inquiry Where to buy Suppliers range | Enasidenib, aslo known as AG-221 and CC-90007, is a potent and selective IDH2 inhibitor with potential anticancer activity (IDH2 = Isocitrate dehydrogenase 2). Synonyms: AG-221; AG 221; AG221; CC-90007; CC 90007; CC90007; Enasidenib. Grades: 98%. CAS No. 1446502-11-9. Molecular formula: C19H17F6N7O. Mole weight: 473.38. | |
Enasidenib mesylate Quick inquiry Where to buy Suppliers range | Enasidenib mesylate is a first-in-class, oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes indicated for the treatment of adult patients with replased or refractory acute myeloid leukemia (AML) with an isocitrate dehydrogenase-2 (IDH2) mutation. Synonyms: methanesulfonic acid;2-methyl-1-[[4-[6-(trifluoromethyl)pyridin-2-yl]-6-[[2-(trifluoromethyl)pyridin-4-yl]amino]-1,3,5-triazin-2-yl]amino]propan-2-ol; Enasidenib (mesylate); AG-221 mesylate; Enasidenib mesilate; Enasidenib methanesulfonate; Enasidenib mesylate [USAN]. CAS No. 1650550-25-6. Molecular formula: C20H21F6N7O4S. Mole weight: 569.48. | |
Etiroxate Carboxylic Acid Quick inquiry Where to buy Suppliers range | Thyroxin derivative inhibiting glutamate dehydrogenase, isocitrate dehydrogenase, alcohol dehydrogenase, rat liver mitochondrial phosphorylation and electron transfer. Administration also induces hypothyroid state. Group: Biochemicals. Alternative Names: O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-α-methyl-tyrosine; α-Methyl-DL-thyroxine. Grades: Highly Purified. CAS No. 3414-34-4. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
GSK864 Quick inquiry Where to buy Suppliers range | GSK864 is a cell penetrant, selective allosteric inhibitor of isocitrate dehydrogenase 1 (IDH1) mutant with IC50 values of 8.8, 15.2 and 16.6 nM for IDH1 mutants R132C, R132H, and R132G, respectively. Synonyms: (7S)-1-[(4-fluorophenyl)methyl]-3-N-(4-methoxy-3,5-dimethylphenyl)-7-methyl-5-(1H-pyrrole-2-carbonyl)-4,6-dihydropyrazolo[4,3-c]pyridine-3,7-dicarboxamide; GSK 864; GSK-864. CAS No. 1816331-66-4. Molecular formula: C30H31FN6O4. Mole weight: 558.6. | |
IDH305 Quick inquiry Where to buy Suppliers range | IDH305 is a potent, selective and brain penetrant inhibitor of mutant isocitrate dehydrogenase 1 (IDH1; IC50s = 27, 28, and 6,140 nM for recombinant IDH1R132H, IDH1R132C, and wild-type IDH1, respectively). It suppresses mutant IDH1-dependent 2-HG production and cell proliferation, and exhibits antitumor activity in preclinical studies. Synonyms: (4R)-4-[(1S)-1-fluoroethyl]-3-[2-({(1S)-1-[4-methyl-2'-(trifluoromethyl)[3,4'-bipyridin]-6-yl]ethyl}amino)pyrimidin-4-yl]-1,3-oxazolidin-2-one. Grades: ≥98%. CAS No. 1628805-46-8. Molecular formula: C23H22F4N6O2. Mole weight: 490.45. | |
Itaconic acid Quick inquiry Where to buy Suppliers range | Inhibitor of isocitrate lyase, the key enzyme of the glyoxylate cycle, essential for bacterial growth. Antimicrobial. Antibacterial. Inhibits the growth of bacteria expressing isocitrate lyase. Phosphofructokinase (PFKII) inhibitor. Suppresses glycolysis by decreasing the level of fructose 2,6-bisphosphate, resulting in decreased visceral fat. Might be involved in the regulation of metabolism. Group: Biochemicals. Alternative Names: 2-Methylenebutanedioic Acid; Methylenesuccinic Acid; 2-Methylenebutanedioic Acid; 2-Methylenesuccinic Acid; 2-Propene-1,2-dicarboxylic Acid; 4-Hydroxy-2-methylene-4-oxobutanoic Acid; Methylenebutanedioic Acid; NSC 3357; Propylenedicarboxylic Acid. Grades: Highly Purified. CAS No. 97-65-4. Pack Sizes: 1g, 5g. Molecular Formula: C?H?O?. US Biological Life Sciences. | Worldwide |
L-Ornithine α-Ketoglutarate Monohydrate Quick inquiry Where to buy Suppliers range | L-Ornithine is a non-essential amino acid, metabolized to generate L-arginine, which is further incorporated into proteins. α-Ketoglutarate is a key intermediate in the Krebs cycle, coming after isocitrate and before succinyl CoA. Acting as a co-substrate, α-Ketoglutarate also plays important function in oxidation reactions involving molecular oxygen. Uses: API. Product ID: 10-101-118. | |
ML-309 hydrochloride Quick inquiry Where to buy Suppliers range | ML-309 is a potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (IDH1). It reduces 2-hydroxyglutarate production in U87 MG glioblastoma cells. Synonyms: ML 309 hydrochloride; ML309 hydrochloride; ML-309 HCl; 2-(N-[2-(benzimidazol-1-yl)acetyl]-3-fluoroanilino)-N-cyclopentyl-2-(2-methylphenyl)acetamide hydrochloride. Grades: ≥98%. CAS No. 1355327-02-4. Molecular formula: C29H29FN4O2·HCl. Mole weight: 521. | |
Olutasidenib Quick inquiry Where to buy Suppliers range | Olutasidenib is a mutant isocitrate dehydrogenase 1 (IDH1) inhibitor used to treat acute myeloid leukemia. Synonyms: FT-2102; FT2102. CAS No. 1887014-12-1. Molecular formula: C18H15ClN4O2. Mole weight: 354.8. | |
Oxalomalic acid sodium salt Quick inquiry Where to buy Suppliers range | Oxalomalic acid is an inhibitor of both aconitase and NADP-dependent isocitrate dehydrogenase, At 5 mM, oxalomalic acid inhibition of aconitase leads to a decrease in the binding activity of IRP1 and a decrease in glutamate secretion in cultured lens epithelial cells, retinal pigment epithelial cells, and neurons. Synonyms: Oxalomalic acid trisodium salt. Grades: ≥95%. CAS No. 89304-26-7. Molecular formula: C6H6O8·3Na. Mole weight: 275. | |
Salicylanilide Quick inquiry Where to buy Suppliers range | Salicylanilide has a wide range of biological activities, including antiviral, anti-inflammatory, antibacterial and so on. It inhibits HIV virus by targeting HIV-1 integrase or reverse transcriptase. It inhibits mycobacterial isocitrate lyase (ICL) and has a significant antimycobacterial effect. It can be used as an antiseptic. Synonyms: 2-Hydroxybenzanilide; 2-(N-Phenylcarboxamido)phenol; 2-(Phenylaminocarbonyl)phenol; Ansadol; Aseptolan; Hyanilid; N-Phenyl-2-hydroxybenzamide; N-Phenylsalicylamide; NSC 14881; Salicylanilid; Salicylic acid anilide; Salifebrin; Salinide; Salinidol; Salnide; Shirlan; o-Hydroxybenzanilide. Grades: ≥95%. CAS No. 87-17-2. Molecular formula: C13H11NO2. Mole weight: 213.23. | |
TC-E 5008 Quick inquiry Where to buy Suppliers range | TC-E 5008 is a selective and cancer-associated mutant isocitrate dehydrogenase 1 (mIDH1) inhibitor (Ki = 120-190 nM), displaying >60-fold selectivity for mIDH1 (found in ~75% of gliomas) over wild type IDH1. TC-E 5008 also inhibits D-2-hydroxyglutaric acid in cells expressing mIDH1 (EC50 = 2.4 μM). Synonyms: 1-Hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone; 6-benzyl-1-hydroxy-4-methylpyridin-2-one. CAS No. 50405-58-8. Molecular formula: C13H13NO2. Mole weight: 215.25. | |
Vorasidenib Quick inquiry Where to buy Suppliers range | Vorasidenib is a potent and orally available pan-IDH (isocitrate dehydrogenase) mutant form inhibitor. It has the potential for the treatment of various cancers including glioma, acute myeloid leukemia (AML), cholangiocarcinoma and chondrosarcoma. Synonyms: AG-881; 6-(6-chloropyridin-2-yl)-2-N,4-N-bis[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine. CAS No. 1644545-52-7. Molecular formula: C14H13ClF6N6. Mole weight: 414.74. |