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| Product | Description | |
|---|---|---|
| isocitrate dehydrogenase (NAD+) | Requires Mn2+ or Mg2+ for activity. Unlike EC 1.1.1.42, isocitrate dehydrogenase (NADP+), oxalosuccinate cannot be used as a substrate. In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD+-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP+-linked enzyme that is found in both mitochondria and cytoplasm. The enzyme from some species can also use NADP+ but much more slowly. Group: Enzymes. Synonyms: isocitric dehydrogenase; β-ketoglutaric-isocitric carboxylase; isocitric acid dehydrogenase; NAD dependent isocitrate dehydrogenase; NAD isocitrate dehydrogenase; NAD-linked isocitrate dehydrogenase; NAD-specific isocitrate dehydr. Enzyme Commission Number: EC 1.1.1.41. CAS No. 9001-58-5. IDH. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0326; isocitrate dehydrogenase (NAD+); EC 1.1.1.41; 9001-58-5; isocitric dehydrogenase; β-ketoglutaric-isocitric carboxylase; isocitric acid dehydrogenase; NAD dependent isocitrate dehydrogenase; NAD isocitrate dehydrogenase; NAD-linked isocitrate dehydrogenase; NAD-specific isocitrate dehydrogenase; NAD isocitric dehydrogenase; isocitrate dehydrogenase (NAD); IDH (ambiguous); nicotinamide adenine dinucleotide isocitrate dehydrogenase. Cat No: EXWM-0326. |  |
| Isocitrate dehydrogenase (NAD+) from Bacteria, Recombinant | Isocitrate dehydrogenase (IDH) is an enzyme that catalyzes the oxidative decarboxylation of Isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2. This is a two-step process, which involves oxidation of Isocitrate (a secondary alcohol) to oxalosuccinate (a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate. In humans, IDH exists in three isoforms:IDH3 catalyzes the third step of the citric acid cycle while converting NAD+ to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid cycle and use NADP+ as a cofactor instead o...namide adenine dinucleotide Isocitrate dehydrogenase; EC 1.1.1.41. Enzyme Commission Number: EC 1.1.1.41. CAS No. 9001-58-5. IDH. Mole weight: 40 kD (SDS-PAGE). Activity: > 40 Units / mg. Storage: Below -20°C. Form: Lyophilized powder. Source: E. coli. Species: Bacteria. Beta-ketoglutaric-isocitric carboxylase; IDH; Isocitrate dehydrogenase (NAD); Isocitric acid dehydrogenase; Isocitric dehydrogenase; NAD dependent Isocitrate dehydrogenase; NAD Isocitrate dehydrogenase; NAD isocitric dehydrogenase; NAD-linked Isocitrate dehydrogenase; NAD-specific Isocitrate dehydrogenase; Nicotinamide adenine dinucleotide Isocitrate dehydrogenase; EC 1.1.1.41. Cat No: NATE-1041. | |
| isocitrate dehydrogenase (NADP+) | Requires Mn2+ or Mg2+ for activity. Unlike EC 1.1.1.41, isocitrate dehydrogenase (NAD+), oxalosuccinate can be used as a substrate. In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD+-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP+-linked enzyme that is found in both mitochondria and cytoplasm. The enzyme from some species can also use NAD+ but much more slowly. Group: Enzymes. Synonyms: ox. Enzyme Commission Number: EC 1.1.1.42. CAS No. 9028-48-2. IDH. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0327; isocitrate dehydrogenase (NADP+); EC 1.1.1.42; 9028-48-2; oxalosuccinate decarboxylase; oxalsuccinic decarboxylase; isocitrate (NADP) dehydrogenase; isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase; NADP-specific isocitrate dehydrogenase; NADP-linked isocitrate dehydrogenase; NADP-dependent isocitrate dehydrogenase; NADP isocitric dehydrogenase; isocitrate dehydrogenase (NADP-dependent); NADP-dependent isocitric dehydrogenase; triphosphopyridine nucleotide-linked isocitrate dehydrogenase-oxalosuccinate carboxylase; NADP+-linked isocitrate dehydrogenase; IDH (ambiguous); dual-cofactor-specific isocitrate dehydrogenase; NADP+-ICDH; NADP+-IDH; IDP; IDP1; IDP2; IDP3. | |
| Isocitrate Dehydrogenase (NADP+) from Bacteria, Recombinant | Isocitrate dehydrogenase (IDH) (EC 1.1.1.42) is an enzyme that catalyzes the oxidative decarboxylation of Isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2. This is a two-step process, which involves oxidation of Isocitrate (a secondary alcohol) to oxalosuccinate (a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate. In humans, IDH exists in three isoforms:IDH3 catalyzes the third step of the citric acid cycle while converting NAD+ to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid cycle and use NADP+ as a cof...rogenase (NADP+); EC 1.1.1.42; IDH; Isocitrate Dehydrogenase; Dual-cofactor-specific Isocitrate dehydrogenase; IDP; Isocitrate (NADP) dehydrogenase; Isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase; Isocitrate dehydrogenase (NADP); Isocitrate dehydrogenase (NADP-dependent); NADP isocitric dehydrogenase; NADP (+)-ICDH; NADP (+)-IDH; NADP (+)-linked Isocitrate dehydrogenase; NADP-dependent Isocitrate dehydrogenase; NADP-dependent isocitric dehydrogenase; NADP-linked Isocitrate dehydrogenase; NADP-specific Isocitrate dehydrogenase; Oxalosuccinate decarboxylase; Oxalsuccinic decarboxylase; Triphosphopyridine nucleotide-linked Isocitrate dehydrog | |
| Isocitrate Dehydrogenase (NADP+) from Yeast, Recombinant | Isocitrate dehydrogenase (IDH) (EC 1.1.1.42) is an enzyme that catalyzes the oxidative decarboxylation of Isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2. This is a two-step process, which involves oxidation of Isocitrate (a secondary alcohol) to oxalosuccinate (a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate. In humans, IDH exists in three isoforms:IDH3 catalyzes the third step of the citric acid cycle while converting NAD+ to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid cycle and use NADP+ as a cofactor instead of NAD+. They localize to the cytosol as well as the mitochondrion and peroxisome. Group: Enzymes. Synonyms: Isocitrate Dehydrogenase (NADP+); EC 1.1.1.42; IDH; Isocitrate . Enzyme Commission Number: EC 1.1.1.42. CAS No. 9028-48-2. IDH. Activity: r-ICDH activity = 100%. Storage: -20°C. Form: Liquid. Source: Pichia pastoris. Species: Yeast. Isocitrate Dehydrogenase (NADP+); EC 1.1.1.42; IDH; Isocitrate Dehydrogenase; Dual-cofactor-specific Isocitrate dehydrogenase; IDP; Isocitrate (NADP) dehydrogenase; Isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase; Isocitrate dehydrogenase (NADP); Isocitrate dehydrogenase (NADP-dependent); NADP | |
| Isocitrate dehydrogenase, Porcine heart | Isocitrate dehydrogenase, Porcine heart (ICDH) is a citric acid or tricarboxylic acid cycle enzyme, is often used in biochemical studies. Isocitrate dehydrogenase catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate and reduces NAD(P) + to NAD(P)H, it plays important roles in cellular metabolism [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ICDH; IDH. CAS No. 9028-48-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2993. |  |
| isocitrate epimerase | (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate is the commonly occurring isomer of isocitrate. Group: Enzymes. Enzyme Commission Number: EC 5.1.2.6. CAS No. 81210-68-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5393; isocitrate epimerase; EC 5.1.2.6; 81210-68-6. Cat No: EXWM-5393. | |
| isocitrate-homoisocitrate dehydrogenase | Requires Mn2+ and K+ or NH4+ for activity. Unlike EC 1.1.1.41, isocitrate dehydrogenase (NAD+) and EC 1.1.1.87, homoisocitrate dehydrogenase, this enzyme, from Pyrococcus horikoshii, can use both isocitrate and homoisocitrate as substrates. The enzyme may play a role in both the lysine and glutamate biosynthesis pathways. Group: Enzymes. Synonyms: homoisocitrate-isocitrate dehydrogenase; PH1722. Enzyme Commission Number: EC 1.1.1.286. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0194; isocitrate-homoisocitrate dehydrogenase; EC 1.1.1.286; homoisocitrate-isocitrate dehydrogenase; PH1722. Cat No: EXWM-0194. | |
| isocitrate lyase | The isomer of isocitrate involved is (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate. Group: Enzymes. Synonyms: isocitrase; isocitritase; isocitratase; threo-Ds-isocitrate glyoxylate-lyase; isocitrate glyoxylate-lyase. Enzyme Commission Number: EC 4.1.3.1. CAS No. 9045-78-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4898; isocitrate lyase; EC 4.1.3.1; 9045-78-7; isocitrase; isocitritase; isocitratase; threo-Ds-isocitrate glyoxylate-lyase; isocitrate glyoxylate-lyase. Cat No: EXWM-4898. | |
| isocitrate O-dihydroxycinnamoyltransferase | Feruloyl-CoA and 4-coumaroyl-CoA can also act as donors. Group: Enzymes. Enzyme Commission Number: EC 2.3.1.126. CAS No. 112352-88-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2063; isocitrate O-dihydroxycinnamoyltransferase; EC 2.3.1.126; 112352-88-2. Cat No: EXWM-2063. | |
| 2-methylisocitrate dehydratase | The enzyme from the fungus Yarrowia lipolytica (Saccharomycopsis) does not act on isocitrate. Group: Enzymes. Synonyms: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase. Enzyme Commission Number: EC 4.2.1.99. CAS No. 170780-51-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5083; 2-methylisocitrate dehydratase; EC 4.2.1.99; 170780-51-5; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase. Cat No: EXWM-5083. | |
| DL-threo-2-methylisocitrate | DL-threo-2-methylisocitrate is a substrate of isocitrate lyase 1(ICL1). Synonyms: DL-threo-2-methylisocitrate; 71183-66-9; alpha-methylisocitric acid; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylic acid; methylisocitrate; Methylisocitric acid; threo-Pentaric acid, 3-carboxy-2,3-dideoxy-4-C-methyl-; SCHEMBL1533821; CHEBI:15607; DTXSID301209270; LMFA01050444; AKOS030526883; DB04072; HY-16581; C04593; Q27098140; 3-carboxy-2,3-dideoxy-4-C-methyl-L-threo-pentaric acid; rel-(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylic acid; rel-(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylicacid. Grades: >98%. CAS No. 71183-66-9. Molecular formula: C14H20O14. Mole weight: 412.3. |  |
| [isocitrate dehydrogenase (NADP+)] kinase | The enzyme has no activating compound but is specific for its substrate. Phosphorylates and inactivates EC 1.1.1.42, isocitrate dehydrogenase (NADP+). Group: Enzymes. Synonyms: [isocitrate dehydrogenase (NADP)] kinase; ICDH kinase/phosphatase; IDH kinase; IDH kinase/phosphatase; IDH-K/P; IDHK/P; isocitrate dehydrogenase kinase (phosphorylating); isocitrate dehydrogenase kinase/phosphatase; STK3. Enzyme Commission Number: EC 2.7.11.5. CAS No. 83682-93-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3156; [isocitrate dehydrogenase (NADP+)] kinase; EC 2.7.11.5; 83682-93-3; [isocitrate dehydrogenase (NADP)] kinase; ICDH kinase/phosphatase; IDH kinase; IDH kinase/phosphatase; IDH-K/P; IDHK/P; isocitrate dehydrogenase kinase (phosphorylating); isocitrate dehydrogenase kinase/phosphatase; STK3. Cat No: EXWM-3156. | |
| methylisocitrate lyase | The enzyme acts on threo-Ds-2-methylisocitrate, but not on threo-Ds-isocitrate, threo-DL-isocitrate or erythro-Ls-isocitrate. Group: Enzymes. Synonyms: 2-methylisocitrate lyase; MICL; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase. Enzyme Commission Number: EC 4.1.3.30. CAS No. 57827-77-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4909; methylisocitrate lyase; EC 4.1.3.30; 57827-77-7; 2-methylisocitrate lyase; MICL; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase. Cat No: EXWM-4909. | |
| Mutant Isocitrate Dehydrogenase 1 R132H from Human, Recombinant | Mutations of the cytosolic IDH 1 are a common feature in primary human brain cancers. Arginine 132 (R132) of IDH is highly conserved among different isoforms of IDH and is most commonly mutated to Histidine. Mutation of IDH1 R132H leads to accumulation of R(-)-2-hydroxyglutarate (2HG), which correlates with an increased risk for malignant brain tumors. Full-length human idh1 (452 amino acids) with n-terminal hattag. arginine 132 is mutated to histidine. Group: Enzymes. Synonyms: Isocitrate dehydrogenase [NADP] cytoplasmic mutant, R132H; IDH 1 R132H. Purity: > 90% by SDS-PAGE. IDH. Mole weight: 50.9 kDa. Activity: >500 mU/mg. Storage: Lyophilized protein is stable for 1 year at -20°C. Once reconstituted aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. Form: Lyophilized powder with additives. Source: E. coli. Species: Human. Isocitrate dehydrogenase [NADP] cytoplasmic mutant, R132H; IDH 1 R132H; Isocitrate dehydrogenase; Isocitrate Dehydrogenase (NADP+). Cat No: NATE-1649. | |
| Triethyl isocitrate | Triethyl isocitrate. Uses: For analytical and research use. Group: Impurity standards. CAS No. 16496-37-0. Molecular Formula: C12H20O7. Mole Weight: 276.29. Catalog: APB16496370. |  |
| Trimethyl isocitrate | Trimethyl isocitrate. Uses: For analytical and research use. Group: Impurity standards. CAS No. 16496-58-5. Molecular Formula: C9H14O7. Mole Weight: 234.2. Catalog: APB16496585. | |
| 2-Aminotetraline-2-carboxylic acid | 2-Aminotetraline-2-carboxylic acid is a potent and selective IDH1 (isocitrate dehydrogenase 1) mutant inhibitor for the treatment of acute myeloid leukemia. Synonyms: Atc-OH; 2-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid; 2-Aminotetralin-2-carboxylic acid; D,L-2-Aminotetralin-2-carboxylic acid; 2-AMINOTETRALINE-2-CARBOXYLIC ACID; 2-Amino-1,2,3,4-tetrahydro-2-naphthalenecarboxylicacid; 2-amino-3,4-dihydro-1H-naphthalene-2-carboxylic acid; (R)-2-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid; (+/-)-2-Amino-1,2,3,4-tetrahydro-2-naphthoic acid; GSK 321; Atc OH. Grades: ≥ 98% (HPLC). CAS No. 6331-63-1. Molecular formula: C11H13NO2. Mole weight: 191.22. | |
| 2-Bromopropanedioic Acid | 2-Bromopropanedioic Acid is an analog of the competitive inhibitor, malonate. Inhibitory activity towards Isocitrate lyase. Group: Biochemicals. Alternative Names: Bromomalonic Acid; Monobromomalonic Acid. Grades: Highly Purified. CAS No. 600-31-7. Pack Sizes: 250mg. US Biological Life Sciences. |  Worldwide |
| 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming) | Catalyses the dehydration of (2S,3S)-2-methylcitrate, forming the trans isomer of 2-methyl-aconitate (unlike EC 4.2.1.79, which forms only the cis isomer). Part of a propionate degradation pathway. The enzyme from Shewanella oneidensis can also accept citrate and cis-aconitate, but activity with (2S,3S)-2-methylcitrate was approximately 2.5-fold higher. 2-methylisocitrate and isocitrate were not substrates. An iron-sulfur protein. Group: Enzymes. Enzyme Commission Number: EC 4.2.1.117. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4957; 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming); EC 4.2.1.117. Cat No: EXWM-4957. | |
| 2-oxoglutarate carboxylase | A biotin-containing enzyme that requires Mg2+ for activity. It was originally thought that this enzyme was a promoting factor for the carboxylation of 2-oxoglutarate by EC 1.1.1.41, isocitrate dehydrogenase (NAD+), but this has since been disproved. The product of the reaction is unstable and is quickly converted into isocitrate by the action of EC 1.1.1.41. Group: Enzymes. Synonyms: oxalosuccinate synthetase; carboxylating factor for ICDH (incorrect); CFI; OGC. Enzyme Commission Number: EC 6.4.1.7. CAS No. 60382-75-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5818; 2-oxoglutarate carboxylase; EC 6.4.1.7; 60382-75-4; oxalosuccinate synthetase; carboxylating factor for ICDH (incorrect); CFI; OGC. Cat No: EXWM-5818. | |
| (2R,3S)-3-Methylmalic Acid | (2R,3S)-3-Methylmalic Acid is used as one of determinants of performance in isocitrate dehydrogenase of Escherichia coli. Group: Biochemicals. Grades: Highly Purified. CAS No. 152204-30-3. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C5H8O5, Molecular Weight: 148.11. US Biological Life Sciences. | Worldwide |
| aconitate hydratase | Besides interconverting citrate and cis-aconitate, it also interconverts cis-aconitate with isocitrate and, hence, interconverts citrate and isocitrate. The equilibrium mixture is 91% citrate, 6% isocitrate and 3% aconitate. cis-Aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3-tricarboxylate. An iron-sulfur protein, containing a [4Fe-4S] cluster to which the substrate binds. Group: Enzymes. Synonyms: cis-aconitase; aconitase; AcnB; 2-methylaconitate hydratase; citrate(isocitrate) hydro-lyase. Enzyme Commission Number: EC 4.2.1.3. CAS No. 9024-25-3. Aconitase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5020; aconitate hydratase; EC 4.2.1.3; 9024-25-3; cis-aconitase; aconitase; AcnB; 2-methylaconitate hydratase; citrate(isocitrate) hydro-lyase. Cat No: EXWM-5020. | |
| AG-120 | AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Synonyms: (2S)-N-(1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide; AG-120 (racemic); AG120; AG 120; AG-120; RG-120 (racemic); RG-120, RG 120; Ivosidenib (racemic). Grades: 98%. CAS No. 1448346-63-1. Molecular formula: C28H22ClF3N6O3. Mole weight: 582.97. | |
| BAY 1436032 | BAY-1436032 is a highly selective, potent and orally available inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). It is a double-digit nanomolar and selective pan-inhibitor of the enzymatic activity of various IDH1-R132X mutants in vitro and displays potent inhibition of 2-HG release (nanomolar range) in patient derived and engineered cell lines expressing different IDH1 mutants. BAY 1436032 strongly reduces 2-HG (2-hydroxyglutarate) levels in cells carrying IDH1-R132H, -R132C, -R132G, -R132S and -R132L mutations. BAY 1436032 showed a favourable selectivity profile against wtIDH1/2 and a large panel of off-targets in vitro. Synonyms: 3-(2-[[4-(Trifluoromethoxy)phenyl]amino]-1-[(1R,5R)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)propanoic Acid; BAY-1436032. Grades: ≥98%. CAS No. 1803274-65-8. Molecular formula: C26H30F3N3O3. Mole weight: 489.53. | |
| BAY-1436032 | BAY-1436032 is a potent, selective and orally available inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). BAY 1436032 is a double-digit nanomolar and selective pan-inhibitor of the enzymatic activity of various IDH1-R132X mutants in vitro and displayed potent inhibition of 2-HG release (nanomolar range) in patient derived and engineered cell lines expressing different IDH1 mutants. In line with the proposed mode of action, a concentration-dependent lowering of 2-HG was observed in vitro accompanied by differentiation and maturation of mIDH1 tumor cells. Furthermore, BAY 1436032 showed a favourable selectivity profile against wtIDH1/2 and a large panel of off-targets in vitro. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BAY-1436032; BAY 1436032; BAY1436032. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1803274-65-8. Molecular formula: C26H30F3N3O3. Mole weight: 489.54. Purity: >98%. IUPACName: 3-(2-((4-(trifluoromethoxy)phenyl)amino)-1-((1R,5R)-3,3,5-trimethylcyclohexyl)-1H-benzo[d]imidazol-5-yl)propanoic acid. Canonical SMILES: O=C(O)CCC1=CC=C2N([C@H]3CC(C)(C)C[C@@H](C)C3)C(NC4=CC=C(OC(F)(F)F)C=C4)=NC2=C1. Product ID: ACM1803274658. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Crelosidenib | Mutant IDH1-IN-6 is a potent, selective and orally active mutant isocitrate dehydrogenase (IDH) inhibitor with IC 50 s of 6.27 nM, 3.71 nM, 36.9 nM and 11.5 nM for IDH1 R132H , IDH1 R132C , IDH2 R140Q and IDH2 R172K mutant enzymes , respectively. Mutant IDH1-IN-6 is less active at inhibiting the IDH wild-type enzymes [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY3410738; Mutant IDH1-IN-6. CAS No. 2230263-60-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-131312. | |
| D-2-Hydroxyglutarate Dehydrogenase from Acidaminococcus fermentans, Recombinant | D-2-hydroxyglutarate (D2HG) level is significantly increased in metabolic diseases and various cancers such as acute myeloid leukemia. Studies suggest that the detection of D2HG serves as a biomarker assay related to IDH (isocitrate dehydrogenase) mutations. D2HGDH is a special NAD-dependent enzyme which reacts with D2HG specifically and converts D2HG to α-ketoglutarate. D2HGDH is a key enzyme to distinguish between two metabolites, D2HG and L-2-hydroxyglutarate (L2HG), during biomarker assays. Group: Enzymes. Synonyms: D-2-hydroxyglutarate dehydrogenase; D2HGDH; D2HGD. Enzyme Commission Number: EC 1.1.99.39. Purity: > 99% by SDS - PAGE. Mole weight: 39 kDa. Activity: > 90,000 mU/mg. Storage: Can be stored at 4°C up to 2 weeks. For long term storage, aliquot and store at -20°C. Avoid repeated freezing and thawing cycles. Form: Lyophilized in 50mM Tris, pH 8 without any additives. Source: E. coli. Species: Acidaminococcus fermentans. D-2-hydroxyglutarate dehydrogenase; D2HGDH; D2HGD. Cat No: NATE-1660. | |
| Ds(+)-threo-Isocitric acid trisodium salt | Anticoagulant that retains platelets functionality. Buffers Ca2+ activity in physiological range (~1mM). Bypasses the metabolic blockade, may permit heme biosynthesis but does not suffice to reverse the iron-restriction response. Stabilizes the iron-sulfur cluster and is predicted to restore aconitase to its 'high iron' conformation and thereby dissociates the PKC-associated signaling complexes whose hyperactivation impairs Epo responsiveness. Binds IDH (isocitrate dehydrogenase), an excellent candidate for participating, along with aconitase and PKC, in an iron restriction signalosome. Contributes to heme biosynthesis which may account for its greater potency in restoring erythroid differentiation. Group: Biochemicals. Alternative Names: (1R,2S)-1-Hydroxy-1,2,3-propanetricarboxylic acid; (2R,3S)-Isocitric acid trisodium salt. Grades: Highly Purified. CAS No. 903507-52-8. Pack Sizes: 25mg, 100mg. Molecular Formula: C6H5O7 3Na, Molecular Weight: 258.1. US Biological Life Sciences. | Worldwide |
| Enasidenib | Enasidenib, aslo known as AG-221 and CC-90007, is a potent and selective IDH2 inhibitor with potential anticancer activity (IDH2 = Isocitrate dehydrogenase 2). Synonyms: AG-221; AG 221; AG221; CC-90007; CC 90007; CC90007; Enasidenib. Grades: 98%. CAS No. 1446502-11-9. Molecular formula: C19H17F6N7O. Mole weight: 473.38. | |
| Enasidenib mesylate | Enasidenib mesylate is a first-in-class, oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes indicated for the treatment of adult patients with replased or refractory acute myeloid leukemia (AML) with an isocitrate dehydrogenase-2 (IDH2) mutation. Synonyms: methanesulfonic acid;2-methyl-1-[[4-[6-(trifluoromethyl)pyridin-2-yl]-6-[[2-(trifluoromethyl)pyridin-4-yl]amino]-1,3,5-triazin-2-yl]amino]propan-2-ol; Enasidenib (mesylate); AG-221 mesylate; Enasidenib mesilate; Enasidenib methanesulfonate; Enasidenib mesylate [USAN]. CAS No. 1650550-25-6. Molecular formula: C20H21F6N7O4S. Mole weight: 569.48. | |
| Etiroxate Carboxylic Acid | Thyroxin derivative inhibiting glutamate dehydrogenase, isocitrate dehydrogenase, alcohol dehydrogenase, rat liver mitochondrial phosphorylation and electron transfer. Administration also induces hypothyroid state. Group: Biochemicals. Alternative Names: O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-α-methyl-tyrosine; α-Methyl-DL-thyroxine. Grades: Highly Purified. CAS No. 3414-34-4. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| GSK864 | GSK864 is a cell penetrant, selective allosteric inhibitor of isocitrate dehydrogenase 1 (IDH1) mutant with IC50 values of 8.8, 15.2 and 16.6 nM for IDH1 mutants R132C, R132H, and R132G, respectively. Synonyms: (7S)-1-[(4-fluorophenyl)methyl]-3-N-(4-methoxy-3,5-dimethylphenyl)-7-methyl-5-(1H-pyrrole-2-carbonyl)-4,6-dihydropyrazolo[4,3-c]pyridine-3,7-dicarboxamide; GSK 864; GSK-864. CAS No. 1816331-66-4. Molecular formula: C30H31FN6O4. Mole weight: 558.6. | |
| IDH305 | IDH305 is a potent, selective and brain penetrant inhibitor of mutant isocitrate dehydrogenase 1 (IDH1; IC50s = 27, 28, and 6,140 nM for recombinant IDH1R132H, IDH1R132C, and wild-type IDH1, respectively). It suppresses mutant IDH1-dependent 2-HG production and cell proliferation, and exhibits antitumor activity in preclinical studies. Synonyms: (4R)-4-[(1S)-1-fluoroethyl]-3-[2-({(1S)-1-[4-methyl-2'-(trifluoromethyl)[3,4'-bipyridin]-6-yl]ethyl}amino)pyrimidin-4-yl]-1,3-oxazolidin-2-one. Grades: ≥98%. CAS No. 1628805-46-8. Molecular formula: C23H22F4N6O2. Mole weight: 490.45. | |
| Isocitric acid trisodium salt | Isocitric acid trisodium salt (CAS# 1637-73-6 ) is a useful research chemical. Synonyms: Sodium isocitrate; DL-Isocitric acid trisodium salt. Grades: 95 %. CAS No. 1637-73-6. Molecular formula: C6H5Na3O7. Mole weight: 258.07. | |
| Itaconic acid | Inhibitor of isocitrate lyase, the key enzyme of the glyoxylate cycle, essential for bacterial growth. Antimicrobial. Antibacterial. Inhibits the growth of bacteria expressing isocitrate lyase. Phosphofructokinase (PFKII) inhibitor. Suppresses glycolysis by decreasing the level of fructose 2,6-bisphosphate, resulting in decreased visceral fat. Might be involved in the regulation of metabolism. Group: Biochemicals. Alternative Names: 2-Methylenebutanedioic Acid; Methylenesuccinic Acid; 2-Methylenebutanedioic Acid; 2-Methylenesuccinic Acid; 2-Propene-1,2-dicarboxylic Acid; 4-Hydroxy-2-methylene-4-oxobutanoic Acid; Methylenebutanedioic Acid; NSC 3357; Propylenedicarboxylic Acid. Grades: Highly Purified. CAS No. 97-65-4. Pack Sizes: 1g, 5g. Molecular Formula: C?H?O?. US Biological Life Sciences. | Worldwide |
| Ivosidenib | Ivosidenib (AG-120) is an orally active inhibitor of isocitrate dehydrogenase 1 mutant (mIDH1) enzyme , it exhibits profound d-2-hydroxyglutatrate (2-HG) lowering in vivo. Ivosidenib (AG-120) has the potential for AML therapy due to its acceptable safety profile and clinical activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AG-120. CAS No. 1448347-49-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18767. | |
| methanogen homoaconitase | This enzyme catalyses several reactions in the pathway of coenzyme-B biosynthesis in methanogenic archaea. Requires a [4Fe-4S] cluster for activity. In contrast to EC 4.2.1.36, homoaconitate hydratase, this enzyme can catalyse both the dehydration of (R)-homocitrate to form cis-homoaconitate and the subsequent hydration reaction that forms homoisocitrate. In addition to cis-homoaconitate, the enzyme can also catalyse the hydration of the physiological substrates dihomocitrate and trihomocitrate as well as the non-physiological substrate tetrahomocitrate. cis-Aconitate and threo-DL-isocitrate cannot act as substrates, and (S)-homocitrate and trans-homoaconitate act as inhibitors of the enzyme. Group: Enzymes. Synonyms: methanogen HACN. Enzyme Commission Number: EC 4.2.1.114. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4954; methanogen homoaconitase; EC 4.2.1.114; methanogen HACN. Cat No: EXWM-4954. | |
| ML-309 hydrochloride | ML-309 is a potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (IDH1). It reduces 2-hydroxyglutarate production in U87 MG glioblastoma cells. Synonyms: ML 309 hydrochloride; ML309 hydrochloride; ML-309 HCl; 2-(N-[2-(benzimidazol-1-yl)acetyl]-3-fluoroanilino)-N-cyclopentyl-2-(2-methylphenyl)acetamide hydrochloride. Grades: ≥98%. CAS No. 1355327-02-4. Molecular formula: C29H29FN4O2·HCl. Mole weight: 521. | |
| Native Porcine Aconitase | Aconitase catalyses the stereo-specific isomerization of Citrate to Isocitrate via cis-aconitate in the tricarboxylic acid cycle. Aconitase is inhibited by cyanide, sulfide and copper and mercury at low concentRations. It is competitively inhibited by trans-aconitate. Aconitase contains an internal Fe-S cluster which is responsible for its activity. Crude preparation containing aconitase activity. Applications: Aconitase may be usefull in diabetes research as well as to study structural conservation between iron-responsive element binding proteins (ire-bp) and isomerases. Group: Enzymes. Synonyms: cis-aconitase; aconitase; Citrate hydro-lyase; Citrate (Isocitrate) hydro-lyase; EC 4.2.1.3; 9024-25-3; aconitate hydRatase. Enzyme Commission Number: EC 4.2.1.3. CAS No. 9024-25-3. Aconitase. Storage: -20°C. Source: Porcine heart. Species: Porcine. cis-aconitase; aconitase; Citrate hydro-lyase; Citrate (Isocitrate) hydro-lyase; EC 4.2.1.3; 9024-25-3; aconitate hydRatase. Cat No: NATE-0024. | |
| Native Porcine Isocitric Dehydrogenase (NADP) | Isocitrate dehydrogenase (IDH) is an enzyme that catalyzes the oxidative decarboxylation of Isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2. This is a two-step process, which involves oxidation of Isocitrate (a secondary alcohol) to oxalosuccinate (a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate. In humans, IDH exists in three isoforms:IDH3 catalyzes the third step of the citric acid cycle while converting NAD+ to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid cycle and use NADP+ as a cofactor instead of NAD+. They localize to the cytosol as well as the mitochondrion and peroxisome. Group: Enzymes. Synonyms: oxalosuccinate decarboxylase; Isocitrate dehyd. Enzyme Commission Number: EC 1.1.1.42. CAS No. 9028-48-2. IDH. Activity: Type I, 0.5-3.0 unit/mg solid; Type II, 3-20 units/mg protein. Storage: -20°C. Form: Type II, buffered aqueous glycerol solution, Solution in 50% glycerol in EDTA buffer salts, pH 6.0. Source: Porcine heart. Species: Porcine. oxalosuccinate decarboxylase; Isocitrate dehydrogenase (NADP); oxalsuccinic decarboxylase; Isocitrate (NADP) dehydrogenase; Isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase; NADP-specific Isocitrate dehydrog | |
| Olutasidenib | Olutasidenib (FT-2102) is a highly potent, orally active, brain penetrant and selective inhibitor of mutant Isocitrate dehydrogenase 1 (IDH1) , with IC 50 values of 21.2 nM and 114 nM for IDH1- R132H and IDH1- R132C, respectively. Olutasidenib (FT-2102) is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FT-2102. CAS No. 1887014-12-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114226. | |
| Olutasidenib | Olutasidenib is a mutant isocitrate dehydrogenase 1 (IDH1) inhibitor used to treat acute myeloid leukemia. Synonyms: FT-2102; FT2102. CAS No. 1887014-12-1. Molecular formula: C18H15ClN4O2. Mole weight: 354.8. | |
| Oxalomalic acid sodium salt | Oxalomalic acid is an inhibitor of both aconitase and NADP-dependent isocitrate dehydrogenase, At 5 mM, oxalomalic acid inhibition of aconitase leads to a decrease in the binding activity of IRP1 and a decrease in glutamate secretion in cultured lens epithelial cells, retinal pigment epithelial cells, and neurons. Synonyms: Oxalomalic acid trisodium salt. Grades: ≥95%. CAS No. 89304-26-7. Molecular formula: C6H6O8·3Na. Mole weight: 275. | |
| Oxalomalic acid trisodium | Oxalomalic acid (Oxalomalate) trisodium is a aconitase and NADP-dependent isocitrate dehydrogenase inhibitor. Oxalomalic acid trisodium inhibits nitrite production and iNOS protein expression in lipopolysaccharide (HY-D1056)-activated J774 macrophages [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Oxalomalate trisodium. CAS No. 89304-26-7. Pack Sizes: 5 mg. Product ID: HY-131521. | |
| Salicylanilide | Salicylanilide has a wide range of biological activities, including antiviral, anti-inflammatory, antibacterial and so on. It inhibits HIV virus by targeting HIV-1 integrase or reverse transcriptase. It inhibits mycobacterial isocitrate lyase (ICL) and has a significant antimycobacterial effect. It can be used as an antiseptic. Synonyms: 2-Hydroxybenzanilide; 2-(N-Phenylcarboxamido)phenol; 2-(Phenylaminocarbonyl)phenol; Ansadol; Aseptolan; Hyanilid; N-Phenyl-2-hydroxybenzamide; N-Phenylsalicylamide; NSC 14881; Salicylanilid; Salicylic acid anilide; Salifebrin; Salinide; Salinidol; Salnide; Shirlan; o-Hydroxybenzanilide. Grades: ≥95%. CAS No. 87-17-2. Molecular formula: C13H11NO2. Mole weight: 213.23. | |
| TC-E 5008 | TC-E 5008 is a selective and cancer-associated mutant isocitrate dehydrogenase 1 (mIDH1) inhibitor (Ki = 120-190 nM), displaying >60-fold selectivity for mIDH1 (found in ~75% of gliomas) over wild type IDH1. TC-E 5008 also inhibits D-2-hydroxyglutaric acid in cells expressing mIDH1 (EC50 = 2.4 μM). Synonyms: 1-Hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone; 6-benzyl-1-hydroxy-4-methylpyridin-2-one. CAS No. 50405-58-8. Molecular formula: C13H13NO2. Mole weight: 215.25. | |
| trans-aconitate 2-methyltransferase | Also catalyses the formation of the methyl monoester of cis-aconitate, isocitrate and citrate, but more slowly. While the enzyme from Escherichia coli forms (E)-3-(methoxycarbonyl)-pent-2-enedioate as the product, that from Saccharomyces cerevisiae forms (E)-2-(methoxycarbonylmethyl)butenedioate and is therefore classified as a separate enzyme (cf. EC 2.1.1.145, trans-aconitate 3-methyltransferase). Group: Enzymes. Enzyme Commission Number: EC 2.1.1.144. CAS No. 235107-12-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1740; trans-aconitate 2-methyltransferase; EC 2.1.1.144; 235107-12-7. Cat No: EXWM-1740. | |
| trans-aconitate 3-methyltransferase | Also catalyses the formation of the methyl monoester of cis-aconitate, isocitrate and citrate, but more slowly. While the enzyme from Saccharomyces cerevisiae forms (E)-2-(methoxycarbonylmethyl)butenedioate as the product, that from Escherichia coli forms (E)-3-(methoxycarbonyl)-pent-2-enedioate and is therefore classified as a separate enzyme (cf. EC 2.1.1.144, trans-aconitate 2-methyltransferase). Group: Enzymes. Enzyme Commission Number: EC 2.1.1.145. CAS No. 235107-12-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1741; trans-aconitate 3-methyltransferase; EC 2.1.1.145; 235107-12-7. Cat No: EXWM-1741. | |
| Trisodium Isocitric Acid | DL-iso-citric acid trisodium salt is the trisodium salt of isocitric acid. Isocitric acid is the isomer of citric acid. The isocitric acid is an essential substrate in the central metabolic pathway, citric acid cycle (TCA cycle) inside organisms. Since it is an organic acid found in most fruit juices, it is commonly used as a marker to evaluate the authenticity and quality of fruit products, most often citrus juices in food industry. Group: Biochemicals. Alternative Names: Sodium isocitrate; 3-Carboxy-2,3-dideoxypentaric Acid Trisodium Salt. Grades: Highly Purified. CAS No. 1637-73-6. Pack Sizes: 1g. Molecular Formula: C6H8Na3O7, Molecular Weight: 258.07. US Biological Life Sciences. | Worldwide |
| Vorasidenib | Vorasidenib (AG-881) is an orally available, brain penetrant second-generation dual mutant isocitrate dehydrogenases 1 and 2 (mIDH1/2) inhibitor. Vorasidenib (AG-881) exhibits nanomolar inhibition of (D)-2-hydroxyglutarate (D-2-HG), and the IC 50 ranges of 0.04~22 nM against IDH1 R132C, IDH1 R132G, IDH1 R132H and IDH1 R132S and 7~14 nM against IDH2 R140Q and 130 nM against IDH2 R172K. Vorasidenib can be used for the study of grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1/2 mutation [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AG-881. CAS No. 1644545-52-7. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-104042. | |
| Vorasidenib | Vorasidenib is a potent and orally available pan-IDH (isocitrate dehydrogenase) mutant form inhibitor. It has the potential for the treatment of various cancers including glioma, acute myeloid leukemia (AML), cholangiocarcinoma and chondrosarcoma. Synonyms: AG-881; 6-(6-chloropyridin-2-yl)-2-N,4-N-bis[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine. CAS No. 1644545-52-7. Molecular formula: C14H13ClF6N6. Mole weight: 414.74. | |
| Isocitric acid | Isocitric acid is an endogenous metabolite present in Saliva and Cellular_Cytoplasm that can be used for the research of Alzheimer's Disease, Lewy Body Dementia and Anoxia [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 320-77-4. Pack Sizes: 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113228. | |
| Isocitric Acid | Isocitric Acid. Uses: For analytical and research use. Group: Impurity standards. CAS No. 320-77-4. Molecular Formula: C6H8O7. Mole Weight: 192.12. Catalog: APB320774. | |
| Isocitric Acid Trisodium Salt | Isocitric Acid Trisodium Salt. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1637-73-6. Molecular Formula: C6H5Na3O7. Mole Weight: 258.07. Catalog: APB1637736. | |
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