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| Product | Description | |
|---|---|---|
| Carbonic anhydrase (isoenzyme) | Carbonic anhydrase isoenzyme is the isoenzyme of Carbonic anhydrase (HY-P1775). Carbonic anhydrase isoenzyme is ubiquitous zinc-containing metalloenzyme present in prokaryotes and eukaryotes. Carbonic anhydrase isoenzyme catalyzes reversible conversion of carbon dioxide to bicarbonate and protons, and can be used for the research of cancer, glaucoma, obesity and epilepsy [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9001-03-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P1775A. |  |
| Creatine Kinase MB Isoenzyme Type-1 from Human, Recombinant | The three isoenzymes (MM, MB, and BB) are found in muscle, cardiac and brain tissues. These recombinant proteins are ideal for calibrating diagnostic instruments and researching neuromuscular diseases. Creatine Kinases can be used for indications in many neuromuscular applications. These disorders include cardiac disease, mitochondrial disorders, inflammatory myopathies, myasthenia, polymyositis, McArdle's disease, NMJ disorders, muscular dystrophy, ALS, hypo and hyperthyroid disorders, central core disease, acid maltase deficiency, myoglobinuria, rhabdomyolysis, motor neuron diseases, rheumatic diseases, and other that create elevated or reduced levels of Creat... in elisa. the ckmbiti is purified by proprietary chromatographic techniques. Group: Enzymes. Synonyms: Creatine Kinase MB Isoenzyme Type-I; Creatine Kinase MB Isoenzyme Type-1; CKMBITI; CKMBI; CKMB; CKMBT1. Purity: Greater than 95.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. CK. Activity: 500 IU/mg. Stability: CKMBITI although stable at 15°C for 7 days, should be stored below -18°C. Please prevent freeze-thaw cycles. Appearance: Sterile Filtered colourless liquid formulation. Source: Pichia Pastoris. Species: Human. Creatine Kinase MB Isoenzyme Type-I; Creatine Kinase MB Isoenzyme Type-1; CKMBITI; CKMBI; CKMB; CKMBT1. Cat No: NATE-0818. |  |
| Creatine Kinase MB Isoenzyme Type-2 from Human, Recombinant | CK-MB Type II possesses the naturally occurring carboxy-terminal amino acid lysine. This occurs during a myocardial infarct (MI or heart attack) when CK-MB Type II is released from damaged heart muscle, and the C-terminal lysine is cleaved in the blood stream, thus creating CK-MB Type I. This difference can be exploited in diagnosis of an MI. Ckmbitii human recombinant produced in pichia pastoris is a glycosylated polypeptide chain having an identical amino acid sequence compared to the native enzyme, purified under non-denaturing conditions and reacts with polyclonal antibodies to mb isoenzyme in elisa. the ckmbitii is purified by proprietary chromatographic techniques. Group: Enzymes. Synonyms: Creatine Kinase MB Isoenzyme Type-II; Creatine Kinase MB Isoenzyme Type-2; CKMBT2; CKMBITII; CKMBII; CKMB. Purity: Greater than 95.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. CK. Activity: 892 IU/mg. Stability: CKMBITII although stable at 15°C for 7 days, should be stored below -18°C. Please prevent freeze-thaw cycles. Appearance: Sterile Filtered colourless liquid formulation. Source: Pichia Pastoris. Species: Human. Creatine Kinase MB Isoenzyme Type-II; Creatine Kinase MB Isoenzyme Type-2; CKMBT2; CKMBITII; CKMBII; CKMB. Cat No: NATE-0819. | |
| Creatine Kinase MM Isoenzyme Type-1 from Human, Recombinant | Creatine Kinase MM is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. Ckmt1 human recombinant without c-terminal lysine on both chains produced in pichia pastoris is a glycosylated 47kda polypeptide chain having an identical amino acid sequence compared to t...proprietary chromatographic techniques. Group: Enzymes. Synonyms: Creatine kinase M-type; EC 2.7.3.2; Creatine kinase M chain; M-CK; CKM; CKMM; CKMMITI; CKMMT1. Enzyme Commission Number: EC 2.7.3.2. Purity: Greater than 95.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. CK. Mole weight: 47kDa. Activity: 537 IU/mg. Stability: CKMT1 although stable at 15°C for 7 days, should be stored below -18°C. Please prevent freeze-thaw cycles. Appearance: Sterile Filtered colourless liquid formulation. Source: Pichia Pastoris. Species: Human. Creatine kinase M-type; EC 2.7.3.2; Creatine kinase M chain; M-CK; CKM; CKMM; CKMMITI; CKMMT1. Cat No: NATE-0820. | |
| Creatine Kinase MM Isoenzyme Type-3 from Human, Recombinant | Creatine Kinase MM is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. Ckmt3 human recombinant produced in pichia pastoris is a glycosylated polypeptide chain having an identical amino acid sequence compared to the native enzyme, purified under non-denaturing conditions and reacts with polyclonal antibodies to mm isoenzyme in elisa.the ckmt3 is purified by proprietary chromatographic techniques. Group: Enzymes. Synonyms: Creatine kin. Enzyme Commission Number: EC 2.7.3.2. Purity: Greater than 95.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. CK. Activity: 500 IU/mg. Stability: CKMT3 although stable at 15°C for 7 days, should be stored below -18°C. lease prevent freeze-thaw cycles. Appearance: Sterile Filtered colourless liquid formulation. Source: Pichia Pastoris. Species: Human. Creatine kinase M-type; EC 2.7.3.2; Creatine kinase M chain; M-CK; CKM; CKMM; CKMMITIII; CKMMT3. Cat No: NATE-0821. | |
| Esterase Isoenzyme 1 from Porcine liver, Recombinant | An esterase is a hydrolase that splits esters into acids and alcohols. Applications: Esterase isoenzymes may be used to identify the mon ocytic element in normal and leukemic cells. they may be used for the bi ochemical characterization of different hematopoietic cell lineages and stages of differentiation when studying leukemias and lymphomas. esterase isoenzyme is recombinant and from porcine liver. it is expressed in e. coli. Group: Enzymes. Synonyms: EC 3.1.1.1; Esterase Isoenzyme 1; 9016-18-6; carboxylesterase; ali-esterase; B-esterase; monobutyrase; cocaine esteras. Enzyme Commission Number: EC 3.1.1.1. CAS No. 9016-18-6. Esterase. Activity: > 30.0 U/g. Storage: -20°C. Source: E. coli. Species: Porcine liver. EC 3.1.1.1; Esterase Isoenzyme 1; 9016-18-6; carboxylesterase; ali-esterase; B-esterase; monobutyrase; cocaine esterase; procaine esterase; methylbutyrase; vitamin A esterase; butyryl esterase; carboxyesterase; carboxylate esterase; carboxylic esterase; methylbutyrate esterase; triacetin esterase; carboxyl ester hydrolase; butyrate esterase; methylbutyrase; α-carboxylesterase; propionyl esterase; nonspecific carboxylesterase; esterase D; esterase B; esterase A; serine esterase; carboxylic acid esterase; cocaine esterase. Pack: Bottomless glass bottle. Contents are inside inserted fused cone. Cat No: NATE-0229. | |
| Esterase Isoenzyme 2 from Porcine liver, Recombinant | An esterase is a hydrolase that splits esters into acids and alcohols. Applications: Esterase isoenzymes may be used to identify the mon ocytic element in normal and leukemic cells. they may be used for the bi ochemical characterization of different hematopoietic cell lineages and stages of differentiation when studying leukemias and lymphomas. esterase isoenzyme 2, is from porcine liver and is recombinant and expressed in e. coli. Group: Enzymes. Synonyms: EC 3.1.1.1; Esterase Isoenzyme 2; 9016-18-6; carboxylesterase; ali-esterase; B-esterase; monobutyrase; cocaine estera. Enzyme Commission Number: EC 3.1.1.1. CAS No. 9016-18-6. Esterase. Activity: > 80 U/g. Storage: -20°C. Source: E. coli. Species: Porcine liver. EC 3.1.1.1; Esterase Isoenzyme 2; 9016-18-6; carboxylesterase; ali-esterase; B-esterase; monobutyrase; cocaine esterase; procaine esterase; methylbutyrase; vitamin A esterase; butyryl esterase; carboxyesterase; carboxylate esterase; carboxylic esterase; methylbutyrate esterase; triacetin esterase; carboxyl ester hydrolase; butyrate esterase; methylbutyrase; α-carboxylesterase; propionyl esterase; nonspecific carboxylesterase; esterase D; esterase B; esterase A; serine esterase; carboxylic acid esterase; cocaine esterase. Pack: Bottomless glass bottle. Contents are inside inserted fused cone. Cat No: NATE-0230. | |
| Esterase Isoenzyme 3 from Porcine liver, Recombinant | An esterase is a hydrolase that splits esters into acids and alcohols. Applications: Esterase isoenzymes may be used to identify the mon ocytic element in normal and leukemic cells. they may be used for the biochemical characterization of different hematopoietic cell lineages and stages of differentiation when studying leukemias and lymphomas. Group: Enzymes. Synonyms: EC 3.1.1.1; ali-esterase; B-esterase; monobutyrase; cocaine esterase; procaine esterase; methylbutyrase; vitamin A esterase; butyryl esterase; carboxyesterase; carboxylate esterase; carboxylic esterase. Enzyme Commission Number: EC 3.1.1.1. CAS No. 9016-18-6. Esterase. Activity: > 0.8 units/mg. Storage: -20°C. Source: E. coli. Species: Porcine liver. EC 3.1.1.1; Esterase Isoenzyme 3; 9016-18-6; carboxylesterase; ali-esterase; B-esterase; monobutyrase; cocaine esterase; procaine esterase; methylbutyrase; vitamin A esterase; butyryl esterase; carboxyesterase; carboxylate esterase; carboxylic esterase; methylbutyrate esterase; triacetin esterase; carboxyl ester hydrolase; butyrate esterase; methylbutyrase; α-carboxylesterase; propionyl esterase; nonspecific carboxylesterase; esterase D; esterase B; esterase A; serine esterase; carboxylic acid esterase; cocaine esterase. Pack: Bottomless glass bottle. Contents are inside inserted fused cone. Cat No: NATE-0231. | |
| Esterase Isoenzyme 5 from Porcine liver, Recombinant | An esterase is a hydrolase that splits esters into acids and alcohols. Applications: Esterase isoenzymes may be used to identify the mon ocytic element in normal and leukemic cells. they may be used for the bi ochemical characterization of different hematopoietic cell lineages and stages of differentiation when studying leukemias and lymphomas. esterase isoenzyme 5 is recombinant and from porcine liver. it is expressed in e. coli. Group: Enzymes. Synonyms: EC 3.1.1.1; Esterase Isoenzyme 5; 9016-18-6; carboxylesterase; ali-esterase; B-esterase; monobutyrase; cocaine e. Enzyme Commission Number: EC 3.1.1.1. CAS No. 9016-18-6. Esterase. Activity: > 0.5 units/mg. Storage: -20°C. Source: E. coli. Species: Porcine liver. EC 3.1.1.1; Esterase Isoenzyme 5; 9016-18-6; carboxylesterase; ali-esterase; B-esterase; monobutyrase; cocaine esterase; procaine esterase; methylbutyrase; vitamin A esterase; butyryl esterase; carboxyesterase; carboxylate esterase; carboxylic esterase; methylbutyrate esterase; triacetin esterase; carboxyl ester hydrolase; butyrate esterase; methylbutyrase; α-carboxylesterase; propionyl esterase; nonspecific carboxylesterase; esterase D; esterase B; esterase A; serine esterase; carboxylic acid esterase; cocaine esterase. Pack: Bottomless glass bottle. Contents are inside inserted fused cone. Cat No: NATE-0232. | |
| Esterase Isoenzyme 6 from Porcine liver, Recombinant | An esterase is a hydrolase that splits esters into acids and alcohols. Applications: Esterase isoenzymes may be used to identify the mon ocytic element in normal and leukemic cells. they may be used for the bi ochemical characterization of different hematopoietic cell lineages and stages of differentiation when studying leukemias and lymphomas. esterase isoenzyme 6 is recombinant and from porcine liver. it is expressed in e. coli. Group: Enzymes. Synonyms: EC 3.1.1.1; Esterase Isoenzyme 6; 9016-18-6; carboxylesterase; ali-esterase; B-esterase; monobutyrase; cocaine e. Enzyme Commission Number: EC 3.1.1.1. CAS No. 9016-18-6. Esterase. Activity: > 1.2 units/mg. Storage: -20°C. Source: E. coli. Species: Porcine liver. EC 3.1.1.1; Esterase Isoenzyme 6; 9016-18-6; carboxylesterase; ali-esterase; B-esterase; monobutyrase; cocaine esterase; procaine esterase; methylbutyrase; vitamin A esterase; butyryl esterase; carboxyesterase; carboxylate esterase; carboxylic esterase; methylbutyrate esterase; triacetin esterase; carboxyl ester hydrolase; butyrate esterase; methylbutyrase; α-carboxylesterase; propionyl esterase; nonspecific carboxylesterase; esterase D; esterase B; esterase A; serine esterase; carboxylic acid esterase; cocaine esterase. Pack: Bottomless glass bottle. Contents are inside inserted fused cone. Cat No: NATE-0233. | |
| 1,2,3,4-Tetrahydro Staurosporine | Staurosporine derivative for use as isoenzyme PKCα inhibitors and anticancer agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 220038-19-7. Pack Sizes: 500ug. US Biological Life Sciences. |  Worldwide |
| (17 β ) -N-[2, 5-Bis (trifluoromethyl) phenyl]-3-oxo-4-azaandrost-5-ene-17-carboxamide | (17 β ) -N-[2, 5-Bis (trifluoromethyl) phenyl]-3-oxo-4-azaandrost-5-ene-17-carboxamide is an intermediate in the synthesis of Dutasteride (D735000), a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Group: Biochemicals. Grades: Highly Purified. CAS No. 164656-21-7. Pack Sizes: 25mg, 100mg. Molecular Formula: C27H30F6N2O2. US Biological Life Sciences. | Worldwide |
| (17 β ) -N-[2, 5-Bis (trifluoromethyl) phenyl]-3-oxo-androst-4-ene-17-carboxamide | (17 β ) -N-[2, 5-Bis (trifluoromethyl) phenyl]-3-oxo-androst-4-ene-17-carboxamide is an intermediate in the synthesis of Dutasteride (D735000), a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Group: Biochemicals. Grades: Highly Purified. CAS No. 164656-19-3. Pack Sizes: 50mg, 250mg. Molecular Formula: C28H31F6NO2. US Biological Life Sciences. | Worldwide |
| 2-Bromoacetophenone | 2-Bromoacetophenone is a brominated acteophenone derivative. 2-Bromoacetophenone has been shown to completely and irreversibly inactivate human liver aldehyde dehydrogenase (EC 1.2.1.3) isoenzymes E1 and E2. 2-Bromoacetophenone and its derivatives display some inhibitory activity on neutral protein tyrosine.inhibitors. Group: Biochemicals. Alternative Names: 1-Bromo-2-phenylethan-2-one; 1-Phenyl-2-bromoethanone; 2-Bromo-1-phenylethan-1-one; 2-Bromo-1-phenylethanone; 2-Bromoacetophenone; Benzoylmethyl Bromide; Bromoacetophenone; Bromomethyl Phenyl Ketone; NSC 9807; Phenacyl Bromide; Phenyl Bromomethyl Ketone; Stauffer 4644; α-Bromoacetophenone; β-Bromoacetophenone; ω-Bromacetophenone; ω-Bromoacetophenone. Grades: Highly Purified. CAS No. 70-11-1. Pack Sizes: 50g. US Biological Life Sciences. | Worldwide |
| 2-Iodo-3-Oxo-4-aza-5α-androst-17 β-carboxylic Acid | 2-Iodo-3-Oxo-4-aza-5α-androst-17 β-carboxylic Acid is a reactant in the synthesis of Duasteride (D735000), a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Dutasteride is used in the treatment of benign prostatic hyperplasia. Group: Biochemicals. Grades: Highly Purified. CAS No. 140700-63-6. Pack Sizes: 10mg, 100mg. Molecular Formula: C19H28INO3, Molecular Weight: 445.33. US Biological Life Sciences. | Worldwide |
| 2-Ketobutyric Acid | A substrate for the determination of lactate dehydrogenase isoenzymes.This compound is suitable for lactate dehydrogenase (LDH) related research. Group: Biochemicals. Alternative Names: 2-Oxobutanoic Acid; 2-Oxobutyric Acid; 2-Ketobutanoic Acid; 2-Ketobutyric Acid; 2-Oxo-n-butyric Acid; 2-Oxobutanoic Acid; 2-Oxobutyric Acid; 3-Methylpyruvic Acid; NSC 60533; Propionylformic Acid; α-Ketobutyric Acid; α-Oxo-n-butyric Acid; α-Oxobutanoic Acid; α-Oxobutyric Acid; α-keto-n-Butyric Acid. Grades: Reagent Grade. CAS No. 600-18-0. Pack Sizes: 5g, 10g, 25g. US Biological Life Sciences. | Worldwide |
| 3-[1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethoxy]-1,2-propanediol. (Mixture of Diastereomers) | 3-[1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethoxy]-1,2-propanediol is involved in biological studies as microsomal cytochrome P 450 isoenzymes from Penicillium italicum interaction with sterol demethylation inhibitor fungicides. Group: Biochemicals. Grades: Highly Purified. CAS No. 86491-83-0. Pack Sizes: 50mg, 500mg. Molecular Formula: C14H16Cl2N2O3. US Biological Life Sciences. | Worldwide |
| 4-Diethylaminobenzaldehyde | DEAB is a potent inhibitor of cytosolic (class 1) aldehyde dehydrogenase (ALDH) enzymes (IC50 values 0.057 μM, 1.2 μM, 3.0 μM, 1.2 μM, 0.16 μM, and 13 μM for inhibition of ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, and ALDH5A1, respectively). DEAB is also an excellent substrate for ALDH3A1, and an irreversible inhibitor of ALDH7A1 (KI value 100 μM). Uses: 4-(diethylamino)benzaldehyde is a mechanism-based inhibitor for human aldehyde dehydrogenase isoenzymes. potent and reversible inhibitor of mouse and human class i aldehyde dehydrogenase. Synonyms: 4-(diethylamino)benzaldehyde. Grades: 99 %. CAS No. 120-21-8. Molecular formula: C11H15NO. Mole weight: 177.24. |  |
| 4-Methylumbelliferyl 2-acetamido-2-deoxy-b-D-glucopyranoside-6-sulfate sodium salt | It is a fluorescent substrate for isoenzyme A of N-acetyl-β-D-glucosaminidase (Hexosaminidase A). Synonyms: 4-Methylumbelliferyl N-acetyl-b-D-glucosaminide-6-sulfate sodium salt; 4-Methylumbelliferyl 2-acetamido-2-deoxy-6-sulphate-b-D-glucopyranoside sodium salt; 4MU-b-D-galactoside-6-sulphate sodium salt; 4-Methylumbelliferyl-b-D-galactoside-6-sulphate sodium salt; 7-[[2-(Acetylamino)-2-deoxy-6-O-sulfo-β-D-glucopyranosyl]oxy]-4-methyl-2H-1-benzopyran-2-one Monosodium Salt. Grades: ≥95%. CAS No. 142439-99-4. Molecular formula: C18H20NNaO11S. Mole weight: 481.41. | |
| 4-Methylumbelliferyl 2-Acetamido-2-deoxy-b-D-glucopyranoside 6-Sulphate Sodium Salt | 4-Methylumbelliferyl 2-acetamido-2-deoxy-b-D-glucopyranoside 6-sulphate sodium salt is a fluorescent substrate for isoenzyme A of N-acetyl- β-D-glucosaminidase (Hexosaminidase A). It can also be used in biological study of characterization of the mutant β-subunit of β-hexosaminidase for dimer formation responsible for the adult form of Sandhoff disease with the motor neuron disease phenotype. Group: Biochemicals. Grades: Highly Purified. CAS No. 142439-99-4. Pack Sizes: 5mg, 10mg. Molecular Formula: C18H21NO11S; Na, Molecular Weight: 459.422299. US Biological Life Sciences. | Worldwide |
| 4-Oxocyclohexane-1-Carbonitrile | 4-Oxocyclohexane-1-Carbonitrile (CAS# 34916-10-4) is used to prepare nicotinamides as PDE4 D isoenzymes inhibitors. It is also used as an anthranilic acid replacement in niacin receptor agonist. Synonyms: 4-oxocyclohexanecarbonitrile; 4-Oxo-cyclohexanecarbonitrile. CAS No. 34916-10-4. Molecular formula: C7H9NO. Mole weight: 123.15. | |
| 4SC-202 | 4SC-202 is a selective and potent, orallly available inhibitor of histone deacetylases (HDAC) specific for class 1 HDAC isoenzymes, with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. 4SC-202 also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). In addition, 4SC-202 shows a broad anti-proliferative activity towards human cancer cell lines with a mean IC50 of 0.7 μM. Synonyms: 4SC202; 4SC-202; 4SC 202; domatinostat; (E)-N-(2-aminophenyl)-3-(1-((4-(1-methyl-1H-pyrazol-4-yl)phenyl)sulfonyl)-1H-pyrrol-3-yl)acrylamide. CAS No. 910462-43-0. Molecular formula: C23H21N5O3S. Mole weight: 447.51. | |
| 4SC-202 Tosylate | 4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity. HDAC inhibitor 4SC-202 selectively binds to and inhibits class I HDACs leading to an accumulation of highly acetylated histones.This may inhibit tumor cell proliferation in susceptible tumor cells. HDACs, upregulated in many tumor types, are a class of enzymes that deacetylate chromatin histone proteins. Synonyms: 4SC-202; 4SC 202; 4SC202. Grades: 0.98. CAS No. 1186222-89-8. Molecular formula: C30H29N5O6S2. Mole weight: 619.711. | |
| A 438079 hydrochloride | A 438079 hydrochloride is a competitive P2X7 receptor antagonist with pIC50 value of 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line. It protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, but not by inflammasome activation. It partially but significantly prevented the 6-OHDA-induced depletion of striatal DA stores. Synonyms: 3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine hydrochloride;A-438079 HCl;A-438079 hydrochloride; A438079 hydrochloride; A 438079 hydrochloride. Grades: >98 %. CAS No. 899507-36-9. Molecular formula: C13H10Cl3N5. Mole weight: 342.61. | |
| Acefylline | Acefylline, a xanthine derivative, is an adenosine receptor antagonist. Acefylline is a peptidylarginine deiminase (PAD) activator. Acefylline is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline can be used in asthma research [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Theophyllineacetic acid; Theophylline-7-acetic acid. CAS No. 652-37-9. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B1505. | |
| adamalysin | From the venom of the eastern diamondback rattlesnake (Crotalus adamanteus). Two isoenzymes of approx. 24 kDa that inactivate α1-proteinase inhibitor by a single cleavage. In peptidase family M12 (astacin family). Group: Enzymes. Synonyms: Crotalus adamanteus metalloendopeptidase; proteinase I and II; Crotalus adamanteus venom proteinase II; adamalysin II. Enzyme Commission Number: EC 3.4.24.46. CAS No. 74812-51-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4328; adamalysin; EC 3.4.24.46; 74812-51-4; Crotalus adamanteus metalloendopeptidase; proteinase I and II; Crotalus adamanteus venom proteinase II; adamalysin II. Cat No: EXWM-4328. | |
| α-Enolase from Human, Recombinant | Alpha-enolase, also known as Enolase 1, is one of three enolase isoenzymes and a glycolytic enzyme expressed in most tissues. This protein plays a key role in anaerobic metabolism under hypoxic conditions and may act as a cell surface plasminogen receptor during tissue invasion. Abnormal expression of alpha-enolase is associated with tumor progression in some cases of breast and lung cancer. It also has been identified as an auto antigen associated with Hashimoto?s encephalopathy and severe asthma. Group: Enzymes. Synonyms: 2-phospho-D-glycerate hydro-lyase; Alpha-enolase; ENO1; Enolase 1; Non-neural enolase. Purity: > 90% (SDS-PAGE). Enolase. Mole weight: 47.1 kDa. Storage: Store at -70°C. Form: Liquid; 1 mg/mL solution in 20 mM Tris-HCl (pH 7.5) containing 10% glycerol and 1 mM MgSO4. Source: E. coli. Species: Human. 2-phospho-D-glycerate hydro-lyase; Alpha-enolase; ENO1; Enolase 1; Non-neural enolase. Cat No: NATE-0940. | |
| aspartate kinase | The enzyme from Escherichia coli is a multifunctional protein, which also catalyses the reaction of EC 1.1.1.3 homoserine dehydrogenase. This is also the case for two of the four isoenzymes in Arabidopsis thaliana. The equilibrium constant strongly favours the reaction from right to left, i.e. the non-physiological direction of reaction. Group: Enzymes. Synonyms: aspartokinase; AK; β-aspartokinase; aspartic kinase. Enzyme Commission Number: EC 2.7.2.4. CAS No. 9012-50-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3176; aspartate kinase; EC 2.7.2.4; 9012-50-4; aspartokinase; AK; β-aspartokinase; aspartic kinase. Cat No: EXWM-3176. | |
| β-Enolase from Human, Recombinant | Beta-enolase, also known as ENO3, is one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in skeletal muscle cells in the adult. ENO3 play a role in converting phosphoglyceric acid to phosphenolpyruvic acid in the glycolytic pathway. Mutations in its gene can be associated with metabolic myopathies that may result from decreased stability of the enzyme. Recombinant human ENO3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Group: Enzymes. Synonyms: 2-phospho-D-glycerate hydro-lyase; Beta-enolase; ENO3; Enolase 3; Muscle-specific enolase. Purity: > 95% (SDS-PAGE). Enolase. Mole weight: 49 kDa. Storage: Store at -70°C. Form: Liquid; 0.5 mg/mL solution in 20 mM Tris-HCl (pH 8.0) containing 1 mM DTT, 20% glycerol and 0.1 mM NaCl. Source: E. coli. Species: Human. 2-phospho-D-glycerate hydro-lyase; Beta-enolase; ENO3; Enolase 3; Muscle-specific enolase. Cat No: NATE-0941. | |
| Carboxylesterase 1 isoform b from Human, Recombinant | Carboxylesterase 1 is a member of a large multigene carboxylesterase family. These enzymes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. This enzyme is known to hydrolyze aromatic and aliphatic esters and is necessary for cellular cholesterol esterification. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds. Applications: Delivers high catalytic activity, ideal for robust high-throughput screening assays including drug-drug interaction studies, and pharmacokinetic...er: EC 3.1.1.1. CAS No. 9016-18-6. Esterase. Activity: ≥500 units/mg protein. Storage: at -70°C. Form: Liquid. Source: Baculovirus infected BTI insect cells. Species: Human. EC 3.1.1.1; Esterase Isoenzyme 1; 9016-18-6; carboxylesterase; ali-esterase; B-esterase; monobutyrase; cocaine esterase; procaine esterase; methylbutyrase; vitamin A esterase; butyryl esterase; carboxyesterase; carboxylate esterase; carboxylic esterase; methylbutyrate esterase; triacetin esterase; carboxyl ester hydrolase; butyrate esterase; methylbutyrase; α-carboxylesterase; propionyl esterase; nonspecific carboxylesterase; esterase D; esterase B; esterase A; serine esterase; carboxyl | |
| Carboxylesterase 1 isoform c from Human, Recombinant | Carboxylesterase 1 is a member of a large multigene carboxylesterase family. These enzymes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. This enzyme is known to hydrolyze aromatic and aliphatic esters and is necessary for cellular cholesterol esterification. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds. Applications: Delivers high catalytic activity, ideal for robust high-throughput screening assays including drug-drug interaction studies, and pharmacokinetic...er: EC 3.1.1.1. CAS No. 9016-18-6. Esterase. Activity: ≥1000 units/mg protein. Storage: at -70°C. Form: Liquid. Source: Baculovirus infected BTI insect cells. Species: Human. EC 3.1.1.1; Esterase Isoenzyme 1; 9016-18-6; carboxylesterase; ali-esterase; B-esterase; monobutyrase; cocaine esterase; procaine esterase; methylbutyrase; vitamin A esterase; butyryl esterase; carboxyesterase; carboxylate esterase; carboxylic esterase; methylbutyrate esterase; triacetin esterase; carboxyl ester hydrolase; butyrate esterase; methylbutyrase; α-carboxylesterase; propionyl esterase; nonspecific carboxylesterase; esterase D; esterase B; esterase A; serine esterase; carboxy | |
| CDP 840 hydrochloride | CDP 840 hydrochloride is a potent and selective inhibitor of phosphodiesterase 4 (PDE4) (IC50 = 12 nM). It competitively inhibits all PDE4 isoenzymes. Synonyms: CDP840; CDP-840; CDP 840; CDP840 HCl; CDP840HCl. 4-[(2R)-2-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-phenylethyl]-pyridine hydrochloride. Grades: ≥98% by HPLC. CAS No. 162542-90-7. Molecular formula: C25H27NO2.HCl. Mole weight: 409.95. | |
| Chidamide | Chidamide, also known as CS055 and HBI-8000, is an orally bioavailable benzamide type inhibitor of histone deacetylase (HDAC) isoenzymes 1, 2, 3 and 10, with potential antineoplastic activity. Chidamide selectively binds to and inhibits HDAC leading to an increase of acetylation levels of histone protein H3. This agent also inhibits the expression of signaling kinases in the PI3K/Akt and MAPK/Ras signaling pathways and may result in cell cycle arrest and the induction of tumor cell apoptosis. This may inhibit tumor cell proliferation in susceptible tumor cells. HDACs, a class of enzymes that deacetylate chromatin histone proteins, are upregulated in many tumor types and play key roles in gene expression. Compared to some other benzamide type HDAC inhibitors, chidamide is more stable, more resistant to degradation and has a longer half-life. Synonyms: CS055; CS-055; CS 055; HBI-8000; HBI 8000; HBI8000; N-(2-amino-5-fluorophenyl)-4-[[[1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-benzamide. CAS No. 743420-02-2. Molecular formula: C22H19FN4O2. Mole weight: 390.418. | |
| Cletoquine oxalate | Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine oxalate is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine oxalate is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine oxalate has antimalarial effects and has the potential for autoimmune diseases treatment. Group: Inhibitors. Alternative Names: 2-[[4-[ (7-Chloro-4-quinolinyl) amino]pentyl]amino]ethanol Oxalate; (+/-)-Desethylhydroxychloroquine Oxalate. CAS No. 14142-64-4. Molecular formula: C18H24ClN3O5. Mole weight: 397.85. Appearance: Brown Solid. Purity: 0.96. IUPACName: 2-[4-[(7-chloroquinolin-4-yl)amino]pentylamino]ethanol;oxalic acid. Canonical SMILES: CC(CCCNCCO)NC1=C2C=CC(=CC2=NC=C1)Cl. C(=O)(C(=O)O)O. Catalog: ACM14142644. |  |
| CRT0066854 | CRT0066854 is a potent and selective atypical PKC isoenzymes inhibitor. CRT0066854 is against full-length (FL) PKCΙ , PKCζ , and ROCK-II kinases with IC 50 values of 132 nM, 639 nM, and 620 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1438881-19-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18713. | |
| CRT0066854 | CRT0066854 is a selective and ATP-competitive inhibitor of the atypical PKC isoenzymes (IC50 values 639 nM and 132 nM for full-length PKCζ, PKCΙ, respectively). CRT0066854 decreases colony formation in HeLa cells, inhibits LLGL2 phosphorylation and polarized epithelial morphogenesis, and impedes directed migration of NRK cells. Synonyms: CRT0066854; CRT 0066854; CRT-0066854; (2S)-3-Phenyl-N1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]-1,2-propanediamine. Grades: 99%. CAS No. 1438881-19-6. Molecular formula: C24H25N5S. Mole weight: 415.55. | |
| Desethylamiodarone hydrochloride | Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is a major active metabolite of Amiodarone. Desethylamiodarone hydrochloride is formed by CYP3A isoenzymes. Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC 50 of 19.1 μM [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N-desethylamiodarone hydrochloride; LB 33020 hydrochloride. CAS No. 96027-74-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-130353. | |
| D-Homoarginine Hemisulfate | D-Homoarginine Hemisulfate is an enantiomer of L-Homoarginine, which is an inhibitor of alkaline phosphatase isoenzymes. Synonyms: N6-(Aminoiminomethyl)-D-lysine Hemisulfate Salt; (R)-2-Amino-6-guanidinohexanoic Acid Hemisulfate Salt. CAS No. 32733-73-6. Molecular formula: C14H34N8O8S. Mole weight: 474.54. | |
| Diclofenamide | Diclofenamide is a potent carbonic anhydrase inhibitor. Diclofenamide may provide a therapeutic strategy in the inhibition of the human cytosolic isoforms I and II and transmembrane tumor-associated isoenzymes IX and XII. Diclofenamide has been shown to be is effective in the prevention of episodic weakness in both hypokalemic periodic paralysis (HypoPP) and potassium-sensitive periodic paralysis (PSPP). Group: Biochemicals. Alternative Names: 1,3-Disulfamoyl-4,5-dichlorobenzene; 1,3-Disulfamyl-4,5-dichlorobenzene; 3, 4-Dichloro-5-sulfamyl Benzene sulfonamide; 4,5-Dichloro-1,3-disulfamoylbenzene; 4,5-Dichloro-m-benzenedisulfonamide; Antidrasi; CB 8000; Daramide; Daranide; Dichlofenamide; Dichlorophenamide; Dichlorphenamide; Diclofenamid; Glaucol; Oratrol. Grades: Highly Purified. CAS No. 120-97-8. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| Dutasteride-13C6 | Labeled Dutasteride. Dutasteride is a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride. Dutasteride is used in the treatment of benign prostatic hyperplasia. Group: Biochemicals. Alternative Names: (4aR, 4bS, 6aS, 7S, 9aS, 9bS, 11aR) -N-[2, 5-Bis (trifluoromethyl) phenyl]-2, 4a, 4b, 5, 6, 6a, 7, 8, 9, 9a, 9b, 10, 11, 11a-tetradecahydro-4a, 6a-dimethyl-2-oxo-1H-indeno[5, 4-f]quinoline-7-carboxamide-13C6; (5α,17 β)-. Grades: Highly Purified. CAS No. 1217685-27-2. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| Epiblastin A | Epiblastin A is a Casein Kinase 1 (CK1) inhibitor. Epiblastin A engages CK1 isoenzymes in cell lysate and induces efficient conversion of epiblast stem cells (EpiSCs) into embryonic stem cells (cESCs). Group: Inhibitors. Alternative Names: Epiblastin A; AUE. CAS No. 16470-02-3. Molecular formula: C12H10ClN7. Mole weight: 287.71. Appearance: Solid powder. Purity: >98%. IUPACName: 6-(3-Chloro-phenyl)-pteridine-2,4,7-triamine. Canonical SMILES: NC1=NC (N)=C2N=C (C3=CC=CC (Cl)=C3)C (N)=NC2=N1. Catalog: ACM16470023. | |
| Epristeride | Epristeride (ONO-9302) is a selective, specific and orally active uncompetitive inhibitor of human steroid 5 alpha-reductase isoform 2. Epristeride has inhibitory effects for SR isoenzymes types 2 with K i value of 0.7-2 nM. Epristeride can be used for the research of prostatic hyperplasia and acne [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ONO-9302; SKF105657. CAS No. 119169-78-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-107385. | |
| fumarate hydratase | Fumarase (or fumarate hydratase) is an enzyme that catalyzes the reversible hydration/dehydration of fumarate to malate. Fumarase comes in two forms: mitochondrial and cytosolic. The mitochondrial isoenzyme is involved in the Krebs Cycle (also known as the Tricarboxylic Acid Cycle [TCA] or the Citric Acid Cycle), and the cytosolic isoenzyme is involved in the metabolism of amino acids and fumarate. Group: Enzymes. Synonyms: fumarase; L-malate hydro-lyase; (S)-malate hydro-lyase. Enzyme Commission Number: EC 4.2.1.2. CAS No. 9032-88-6. Fumarase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5013; fumarate hydratase; EC 4.2.1.2; 9032-88-6; fumarase; L-malate hydro-lyase; (S)-malate hydro-lyase. Cat No: EXWM-5013. | |
| geranylgeranyl diphosphate diphosphatase | Involved in the biosynthesis of plaunotol. There are two isoenzymes with different ion requirements. Neither require Mg2+ but in addition PII is inhibited by Zn2+, Mn2+ and Co2+. It is not known which isoenzyme is involved in plaunotol biosynthesis. Group: Enzymes. Synonyms: geranylgeranyl diphosphate phosphatase. Enzyme Commission Number: EC 3.1.7.5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3765; geranylgeranyl diphosphate diphosphatase; EC 3.1.7.5; geranylgeranyl diphosphate phosphatase. Cat No: EXWM-3765. | |
| glutaminase | Glutaminase (EC 3.5.1.2, glutaminase I, L-glutaminase, glutamine aminohydrolase) is an amidohydrolase enzyme that generates glutamate from glutamine. Glutaminase has tissue-specific isoenzymes. Glutaminase has an important role in glial cells. Group: Enzymes. Synonyms: glutaminase I; L-glutaminase; glutamine aminohydrolase. Enzyme Commission Number: EC 3.5.1.2. CAS No. 9001-47-2. Glutaminase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4409; glutaminase; EC 3.5.1.2; 9001-47-2; glutaminase I; L-glutaminase; glutamine aminohydrolase. Cat No: EXWM-4409. | |
| hexokinase | D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Group: Enzymes. Synonyms: hexokinase type IV glucokinase; hexokinase D; hexokinase type IV; hexokinase (phosphorylating); ATP-dependent hexokinase; glucose ATP phosphotransferase. Enzyme Commission Number: EC 2.7.1.1. CAS No. 9001-51-8. Hexokinase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2945; hexokinase; EC 2.7.1.1; 9001-51-8; hexokinase type IV glucokinase; hexokinase D; hexokinase type IV; hexokinase (phosphorylating); ATP-dependent hexokinase; glucose ATP phosphotransferase. Cat No: EXWM-2945. | |
| L-Homoarginine-d4 Dihydrochloride | A labeled inhibitor of alkaline phosphatase isoenzymes. A labeled analog of Homoarginine. Group: Biochemicals. Alternative Names: N6-(Aminoiminomethyl)-. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| L-Homoarginine hydrochloride | L-Homoarginine may be used to create non-natural proteins for studies of post-translational protein modifications. Arginine residues are often located at the active centers of proteins and enzymes. Replacing these arginines with homoarginine can elucidate protein function and structural requirements. L-Homoarginine is used to study the mechanisms of nitric oxide production by cells via nitric oxide synthase(s). L-Homoarginine is used as a selective mammalian alkaline phosphatase isoenzyme inhibitor. The substitution of homoarginine for arginine or lysine renders proteins resistant to proteolysis by trypsin. Group: Amino acids. Alternative Names: (S)-2-Amino-6-guanidinohexanoic acid hydrochloride. CAS No. 1483-01-8. Molecular formula: H2NC(=NH)NH(CH2)4CH(NH2)CO2H · HCl. Mole weight: 224.69. Canonical SMILES: Cl[H].N[C@@H](CCCCNC(N)=N)C(O)=O. ECNumber: 216-045-6. Catalog: ACM1483018-1. | |
| L-Homoarginine, Hydrochloride (2-Amino-6-guanidino-hexanoic Acid, HCl) | An inhibitor of alkaline phosphatase isoenzymes. Group: Biochemicals. Alternative Names: 2-Amino-6-guanidino-hexanoic Acid, HCl. Grades: Highly Purified. CAS No. 1483-01-8. Pack Sizes: 2g. US Biological Life Sciences. | Worldwide |
| L-Lactic dehydrogenase | L-Lactic dehydrogenase. Synonyms: IUB: 1.1.1.27;LACTIC DEHYDROGENASE;LACTIC DEHYDROGENASE BOVINE HEART;LACTIC ACID DEHYDROGENASE;LACTATE DEHYDROGENASE;LACTATE DEHYDROGENASE, HUMAN MUSCLE;LACTATE DEHYDROGENASE ISOENZYME-1, HUMAN;L-LACTATE DEHYDROGENASE. CAS No. 9001-60-9. Product ID: CDF4-0043. Category: Enzyme Preparations. Product Keywords: Food Ingredients; Enzyme Preparations; L-Lactic dehydrogenase; CDF4-0043; 9001-60-9; 232-617-8; 9001-60-9. Purity: 0.99. Color: White. EC Number: 232-617-8. Physical State: Suspension. Storage: 2-8°C. |  |
| Native Barley β-Amylase | β-Amylase hydrolyzes the α-(1,4) glucan linkages in polysaccharides of three or more α-(1,4) linked D-glucose units. Natural substrates such as starch and glycogen are broken down into glucose and maltose. Pure, crystalline β-amylase preparation consists of four isoenzymes with different isoelectric points. The enzyme polymerizes very rapidly through the sulfhydryl groups in the absence of reducing agents. p-Chloromercuribenzoate inhibits the polymerization and the enzymatic activity. The reducing agents mercaptoethanol or dithiothreitol can completely restore the activity. Applications: Β-amylase is used to hydrolyze α bonds of α-linked polysaccharides, such as starch and glycogen. β-amylase, has been used in various plant studies, such as carbon starvation studies in populus tremuloides. β-amylase, from barley, has been used to study how pressure and temperature affect catalytic activity. Group: Enzymes. Synonyms: saccharogen amylase; glycogenase; β amylase, β-amylase; 1,4-α-D-glucan maltohydrola. Enzyme Commission Number: EC 3.2.1.2. CAS No. 9000-91-3. β-Amylase. Activity: 20-80 units/mg protein (biuret). Storage: 2-8°C. Source: Barley. saccharogen amylase; glycogenase; β amylase, β-amylase; 1,4-α-D-glucan maltohydrolase; EC 3.2.1.2; 9000-91-3. Cat No: NATE-0761. | |
| Native Escherichia coli Glutaminase | Glutaminase catalyzes the conversion of glutamine to glutamate. Glutaminase is an amidohydrolase enzyme that generates glutamate from glutamine. Glutaminase has tissue-specific isoenzymes. Glutaminase has an important role in glial cells. Glutaminase catalyzes the following reaction:Glutamine + H2O ? Glutamate + NH3. Group: Enzymes. Synonyms: EC 3.5.1.2; glutaminase I; L-glutaminase; glutamine aminohydrolase; Glutaminase; 9001-47-2. Enzyme Commission Number: EC 3.5.1.2. CAS No. 9001-47-2. Glutaminase. Activity: Type I, 500-1,500 units/mg protein; Type II, 50-200 units/mg protein. Storage: -20°C. Form: Type I, Lyophilized powder containing stabilizer and potassium succinate; Type II, Lyophilized powder containing potassium succinate and EDTA. Source: Escherichia coli. EC 3.5.1.2; glutaminase I; L-glutaminase; glutamine aminohydrolase; Glutaminase; 9001-47-2. Cat No: NATE-0307. | |
| Native Human Aspartate Aminotransferase | Aspartate Aminotransferase (AST), also known as Glutamate Oxaloacetate Transaminase (GOT), is a pyridoxal phosphate-dependant enzyme which exists in two isoenzymes; mitochondrial and cytosolic forms. The AST enzyme plays an important role in amino acid metabolism and in the urea and tricarboxylic acid cycles. In liver about 80% of the enzyme activity is mitochondrial in origin, whereas in serum the enzyme activity is largely cytosolic. In hepatic disease, serum levels are used to assess liver necrosis and for determining prognosis. In patients with acute Myocardial infarction, measurement of AST isoenzymes provides diagnostic information that differs from that obtained by determination of other marker proteins. Creative Enzymes products are not intended for use in pharmaceutical applications. Applications: Research life science elisa assay clinical chemistry. Group: Enzymes. Synonyms: EC 2.6.1.1; glutamic-oxaloacetic transaminase; glutamic-aspartic transaminase; transaminase A; AAT; AspT; 2-oxoglutaRate-glutamate aminotransferase; aspartate α-ketoglutaRate transaminase; aspartate aminotransferase; aspartate-2-oxoglutaRate transaminase; aspartic acid aminotransferas. Enzyme Commission Number: EC 2.6.1.1. CAS No. 9000-97-9. AST. Activity: >50U/ml. Storage: -20°C. Source: Human Cardiac Tissue. Species: Human. EC 2.6.1.1; glutamic-oxaloa | |
| Native Human Creatine Kinase BB | Creatine Kinase BB is concentrated in the brain and lungs Because the CKBB isoenzyme, CPK-1 isoenzyme is predominately found in the brain and lungs, injury to either of these organs (for example, stroke or lung injury due to a pulmonary embolism) are associated with elevated levels of this isoenzyme. Group: Enzymes. Synonyms: CPK-1; CKBB isoenyzme; CK-BB; CKB; creatine kinase, brain; CKBB; creatine kinase B-type; creatine kinase-B; creatine kinase B chain; B-CK; Brain-type creatine kinase; Creatine Kinase BB; BB-CK. Enzyme Commission Number: EC 2.7.3.2. CAS No. 9001-15-4. Purity: CK-BB: > 99%. CK-MM: < 1%. CK-MB: < 1%. Activity:> 500 U/mL. Storage: Store at -20° C. Form: Liquid, 50% Glycerol, 25 mM Imidazole, 1 mM DTE, pH 6.5. Source: Human Brain. Species: Human. CPK-1; CKBB isoenyzme; CK-BB; CKB; creatine kinase, brain; CKBB; creatine kinase B-type; creatine kinase-B; creatine kinase B chain; B-CK; Brain-type creatine kinase; Creatine Kinase BB; BB-CK. Cat No: NATE-1885. | |
| Native Human Creatine Kinase MB Fraction | In the cells, the "cytosolic" CK enzymes consist of two subunits, which can be either B (brain type) or M (muscle type). There are, therefore, three different isoenzymes:CK-MM, CK-BB and CK-MB. The genes for these subunits are located on different chromosomes:B on 14q32 and M on 19q13. In addition to those three cytosolic CK isoforms, there are two mitochondrial creatine kinase isoenzymes, the ubiquitous and sarcomeric form. The functional entity of the latter two mitochondrial CK isoforms is an octamer consisting of four dimers each. Applications: The mb isoenzyme of creatine kinase (mbck) can be used as a diagnostic marker for acute myocardial infarction. Group: Enzymes. Synonyms: CK-MB; CKMB; Creatine Kinase MB Fraction; Creatine Kinase MB. Purity: > 70% (SDS-PAGE). Activity: > 1,000 U/mL. Form: liquid. Source: Human heart. Species: Human. CK-MB; CKMB; Creatine Kinase MB Fraction; Creatine Kinase MB. Cat No: NATE-0141. | |
| Native Human Creatine Kinase MM | Human CK-MM isoenzyme also known as human CPK-3 isoenzyme is normally responsible for almost all human CPK enzyme activity in healthy people. When human (CK-MM) CKMM isoenzyme is elevated, this usually indicates injury or stress to skeletal muscle. Group: Enzymes. Synonyms: CKM; creatine kinase, muscle; CKMM; creatine kinase M-type; creatine kinase-M; creatine kinase M chain; CK-MM. Enzyme Commission Number: EC 2.7.3.2. CAS No. 9001-15-4. Purity: CK-MM: > 99% CK-MB: < 1%CK-BB: < 1%. CK. Activity:> 100 U/mg. Stability: 3 years. Appearance: White to off-white powder. Storage: Store at -20° C. Form: Lyophilized from tris chloride, EDTA and DTT, pH 7.5. Source: Human Skeletal Muscle. Species: Human. CKM; creatine kinase, muscle; CKMM; creatine kinase M-type; creatine kinase-M; creatine kinase M chain; CK-MM. Cat No: NATE-1883. | |
| Native Human Lactate Dehydrogenase 4 | A lactate dehydrogenase (LDH or LD) is an enzyme found in nearly all living cells (animals, plants, and prokaryotes). LDH catalyzes the conversion of pyruvate to lactate and back, as it converts NADH to NAD+ and back. A dehydrogenase is an enzyme that transfers a hydride from one molecule to another. Applications: Diagnostic controls, calibrators & standards; clinical chemistry; testing/assay validation; life science; validation studies; manufacturing. Group: Enzymes. Synonyms: LDH-4 isoenzyme; 1H3M isoenzyme; ld4 isoenyzme. Enzyme Commission Number: EC 1.1.1.27. CAS No. 9001-60-9. LDH. Activity: > 35 U/mg protein (> 110 U/mL). Stability: 2 years. Storage: 2-8°C. Form: Liquid; Suspension in 3.1 M ammonium sulfate, 20 mM tris chloride, 1 mM DTT, 1 mM EDTA, pH 7.5. Source: Human Liver. Species: Human. LDH-4 isoenzyme; 1H3M isoenzyme; ld4 isoenyzme; Lactate dehydrogenase; EC 1.1.1.27; LDH; LD. Cat No: NATE-0965. | |
| Native Human Neuron Specific Enolase | Neuron specific enolase (NSE) is an enzyme that in humans is encoded by the ENO2 gene. Gamma-enolase is a phosphopyruvate hydratase. Gamma-enolase is one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. Applications: Neuron-specific enolase from human brain has been used in a study to assess human amniotic mesenchymal stem cells in the treatment of focal cerebral ischemia. it has also been used in a study to investigate sinonasal teratocarcinosarcoma with rhabdoid features. Group: Enzymes. Synonyms: EC 4.2.1.11; Neuron Specific Enolase; NSE; enolase; 2-phosphoglycerate dehydratase; 14-3-2-protein; nervous-system specific enolase; phosphoenolpyruvate hydra. Enzyme Commission Number: EC 4.2.1.11. CAS No. 9014-8-8. Enolase. Storage: -20°C. Form: buffered aqueous solution. Source: Human brain. Species: Human. EC 4.2.1.11; Neuron Specific Enolase; NSE; enolase; 2-phosphoglycerate dehydratase; 14-3-2-protein; nervous-system specific enolase; phosphoenolpyruvate hydratase; 2-phosphoglycerate dehydratase; 2-phosphoglyceric dehydratase; 2-phosphoglycerate enolase; γ-enolase; 2-phospho-D-glycerate hydro-lyase; phosphopyruvate hydratase. Cat No: DIA-225. | |
| Native Porcine Creatine Kinase BB | Creatine Kinase BB is concentrated in the brain and lungs Because the CKBB isoenzyme, CPK-1 isoenzyme is predominately found in the brain and lungs, injury to either of these organs (for example, stroke or lung injury due to a pulmonary embolism) are associated with elevated levels of this isoenzyme. Applications: Diagnostic controls, calibrators & standards; immunoassays; clinical chemistry; testing/assay validation; life science; manufacturing. Group: Enzymes. Synonyms: CPK-1; CKBB isoenyzme; CK-BB; CKB; creatine kinase, brain; CKBB; creatine kinase B-type; creatine kinase-B; creatine kinase B chain; B-CK; Brain-type creatine kinase; Creatine Kinase BB; BB-CK. Enzyme Commission Number: EC 2.7.3.2. CAS No. 9001-15-4. CK. Activity: > 100 U/mg. Stability: 3 years. Storage: Store at -20°C. Form: Lyophilized from 10 mM tris-succinate, 2 mM DTT, 2 mM EDTA, pH 6.5. Source: Porcine Brain. Species: Porcine. CPK-1; CKBB isoenyzme; CK-BB; CKB; creatine kinase, brain; CKBB; creatine kinase B-type; creatine kinase-B; creatine kinase B chain; B-CK; Brain-type creatine kinase; Creatine Kinase BB; BB-CK. Cat No: NATE-0958. | |
| Native Porcine Creatine Phosphokinase | Creatine phosphokinase (CPK) is widely distributed and is primarily involved with ATP regeneration in conjunction with the contractile and transport systems. The enzyme is dimeric and exists in three isoenzyme forms: MM (muscle), MB (heart) and BB (brain). CPK from rabbit muscle has a molecular weight of 81,000 The hybrid isoenzyme (MB) has the highest concentration in the heart muscle. Therefore, determination of the serum CPK level of this isoenzyme has been used as a sensitive index for the diagnosis of myocardial infarction. Elevated levels of the BB isoenzyme of CPK have been reported in the serum of patients immediately following cardiac surgery. The CPK-BB levels in serum returned to normal by the fourth post-operative day. This may be a more sensitive diagnostic tool than the serum levels of CPK-MB isoenzyme in cardiac patients. Group: Enzymes. Syn. Enzyme Commission Number: EC 2.7.3.2. CAS No. 9001-15-4. Purity: 0.95. CK. Activity: >300 U/mg protein. Storage: Store at -20° C. Form: Freeze-dried powder. Source: Porcine Heart. Species: Porcine. EC 2.7.3.2; ATP:creatine phosphotransferase; CK; CPK; MM-CK; MB-CK; BB-CK; creatine phosphokinase; creatine phosphotransferase; phosphocreatine kinase; adenosine triphosphate-creatine transphosphorylase; Mi-CK; CK-BB; CK-MM; CK-MB; CKMiMi; MiMi-CK; 9001-15-4; Creatine kinase. Cat No: NATE-1869. | |
| Native Potatoes Apyrase | Apyrase is found in all eukaryotes and some prokaryotes. Apyrase, from potato, has a crucial role in regulating growth and development. Apyrase is involved in the inactivation of synaptic ATP as a neurotransmitter following nerve stimulation and in the inhibition of ADP induced platelet aggregation to prevent thrombosis. Divalent metal ions are required for activity and best activity is observed with calcium ion at 5 mM. Applications: At least two isoenzymes are found in different varieties of s. tuberosum:4,5 one with a high atpase/adpase ratio (~10) and another with a low ratio (~1). reaction: atp ? adp+pi ? amp+2pi.apyrase is used to hydrolyze nucleoside triphosphates and diphosphates. for hydrolysis of organic di and triphosphates, the optimal ph is 6, and for inorganic substrates, the optimal ph is 5.1. apyrase, from creative enzymes, has been used in inhibition studies of platelet-aggregation. Group: Enzymes. Synonyms: ATP-diphosphatase; adenosine diphosphatase. Enzyme Commission Number: EC 3.6.1.5. CAS No. 9000-95-7. Apyrase. Activity: > 200 units/mg protein; > 600 units/mg protein. Storage: -20°C. Form: lyophilized powder. Partially purified, lyophilized powder containing potassium succinate buffer salts. Source: Potatoes. ATP-diphosphatase; adenosine diphosphatase; ADPase; ATP diphosphohydrolase; apyrase; EC 3.6.1.5; 9000-95-7. Cat No: NATE-0085. | |
| Native Sweet potato β-Amylase | β-Amylase hydrolyzes the α-(1,4) glucan linkages in polysaccharides of three or more α-(1,4) linked D-glucose units. Natural substrates such as starch and glycogen are broken down into glucose and maltose. Pure, crystalline β-amylase preparation consists of four isoenzymes with different isoelectric points. The enzyme polymerizes very rapidly through the sulfhydryl groups in the absence of reducing agents. p-Chloromercuribenzoate inhibits the polymerization and the enzymatic activity. The reducing agents mercaptoethanol or dithiothreitol can completely restore the activity. Applications: Β-amylase is used to hydrolyze α bonds of α-linke...ng and removing staphylococcus aureus biofilms. the enzyme has also been used to prepare β-limit dextrin from waxy maize starch. Group: Enzymes. Synonyms: saccharogen amylase; glycogenase; β amylase, β-amylase; 1,4-α-D-glucan maltohydrolase; EC 3.2.1.2; 9000-91-3. Enzyme Commission Number: EC 3.2.1.2. CAS No. 9000-91-3. β-Amylase. Mole weight: 127.5. Activity: > 750 units/mg protein (E1%/280). Storage: 2-8°C. Form: ammonium sulfate suspension. Crystalline suspension in 2.3 M (NH4)2SO4. Source: Sweet potato. saccharogen amylase; glycogenase; β amylase, β-amylase; 1,4-α-D-glucan maltohydrolase; EC 3.2.1.2; 9000-91-3. Cat No: NATE-0762. | |
| Nefazodone | Nefazodone is an orally active phenylpiperazine antidepressant. Nefazodone can potently and selectively block postsynaptic 5-HT 2A receptors , and moderately inhibit 5-HT and noradrenaline reuptake. Nefazodone can also relieve the adverse effects of stress on the the immune system of mice. Nefazodone has a high affinity for CYP3A4 isoenzyme, which indicates that it has certain risk of agent-agent interaction [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 83366-66-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119209. | |
| Nitric Oxide Synthase, Inducible from mouse, Recombinant | Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS). The inducible isoform, iNOS, is involved in immune response, binds calmodulin at physiologically relevant concentrations, and produces NO as an immune defense mechanism, as NO is a free ...DPH); Inducible Nitric Oxide Synthase; NOS II; iNOS; macNOS; EC 1.14.13.39; NOSs. Enzyme Commission Number: EC 1.14.13.39. CAS No. 125978-95-2. NOSs. Mole weight: mol wt 130 kDa (homodimer); mol wt 130 kDa (subunit, homodimer). Storage: -70°C. Form: buffered aqueous solution; Solution in 50 mM HEPES, pH 7.4, with 10% glycerol, 8 μM tetrahydrobiopterin. Source: E. coli. Species: Mouse. nitric oxide synthetase; endothelium-derived relaxation factor-forming enzyme; endothelium-derived relaxing factor synthase; NO synthase; NADPH-diaphorase; nitric-oxide synthase (NADPH); Inducible Nitric Oxide Synthase; NOS II; iNOS; macNOS; EC 1.14.13.39; NOSs. Cat No: NATE-0489. | |
| Nitrosoglutathione | Nitrosoglutathione (GSNO), a exogenous NO donor and a substrate for rat alcohol dehydrogenase class III isoenzyme, inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSNO; RVC-588; S-Nitroso-L-glutathione. CAS No. 57564-91-7. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-D0845. | |
| Peroxidase | Peroxidase. Synonyms: Peroxidase froM horseradish(EIA Grade,Purified);84 kDa myeloperoxidase;89 kDa myeloperoxidase;ANTI-MYELOPEROXIDASE(N-TERMINAL) antibody produced in rabbit;Myeloperoxidase light chain;Apoperoxidase;Peroxidase isoenzymes Type XI: Apoenzyme from horseradish;ANTI-MYELOPEROXIDASE (CENTER) antibody produced in rabbit. CAS No. 9003-99-0. Product ID: CDF4-0034. Category: Enzyme Preparations. Product Keywords: Food Ingredients; Enzyme Preparations; Peroxidase; CDF4-0034; 9003-99-0; 232-668-6; 9003-99-0. Purity: 0.99. Color: Red-Brown. EC Number: 232-668-6. Physical State: Powder. Solubility: H2O: soluble. | |
| Piclamilast | Piclamilast is a potent and selective phosphodiesterase-4 (PDE4) inhibitor (IC50 = 1 nM at PDE4 from human neutrophils) with >19,000-fold selectivity over other PDE isoenzymes. Uses: Phosphodiesterase 4 inhibitors. Synonyms: Piclamilast; RP-73401; RP 73-401; RP 73401; RP 73 401; RP73401; RP 73401; 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide; N-(3,5-Dichloropyrid-4-yl)-3-cyclopentyloxy-4-methoxybenzamide. Grades: ≥99% by HPLC. CAS No. 144035-83-6. Molecular formula: C18H18Cl2N2O3. Mole weight: 381.25. | |
| PKR-IN-1 | Activator of pyruvate kinase isoenzyme M2 (PKM2), an enzyme involved in glycolysis. Since all tumor cells exclusively express the embryonic M2 isoform of PK, it is hypothesized that PKM2 is a potential target for cancer therapy. Modulation of PKM2 might also be effective in the treatment of obesity, diabetes, autoimmune conditions, and antiproliferation-dependent diseases. Synonyms: PKR-IN-1; PKM2 activator 1020; PKM2 activator; Mitapivat. Grades: >98%. CAS No. 1260075-17-9. Molecular formula: C24H26N4O3S. Mole weight: 450.55. | |
| protoporphyrinogen oxidase | This is the last common enzyme in the biosynthesis of chlorophylls and heme. Two isoenzymes exist in plants: one in plastids and the other in mitochondria. This is the target enzyme of phthalimide-type and diphenylether-type herbicides. The enzyme from oxygen-dependent species contains FAD. Also slowly oxidizes mesoporphyrinogen IX. Group: Enzymes. Synonyms: protoporphyrinogen IX oxidase; protoporphyrinogenase; PPO; Protox; HemG; HemY. Enzyme Commission Number: EC 1.3.3.4. CAS No. 53986-32-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1378; protoporphyrinogen oxidase; EC 1.3.3.4; 53986-32-6; protoporphyrinogen IX oxidase; protoporphyrinogenase; PPO; Protox; HemG; HemY. Cat No: EXWM-1378. | |
| Roflumilast | Roflumilast (APTA-2217) is a selective PDE4 inhibitor with IC 50 s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1 , PDEA4 , PDEB1 , and PDEB2 , respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells. Uses: Scientific research. Group: Signaling pathways. Alternative Names: APTA-2217; BYK 20869; B9302-107. CAS No. 162401-32-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15455. | |
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