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| Product | Description | |
|---|---|---|
| Ivacaftor | Ivacaftor. Group: Biochemicals. Alternative Names: N-[2,4-Bis[1,1-di(methyl-d3)ethyl-2,2,2-d3]-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide; Ivacaftor; Kalydeco; VX 770. Grades: Highly Purified. CAS No. 873054-44-5. Pack Sizes: 5mg. Molecular Formula: C24H28N2O3, Molecular Weight: 392.49. US Biological Life Sciences. |  Worldwide |
| Ivacaftor | Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC 50 s of 100 nM and 25 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VX-770. CAS No. 873054-44-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13017. |  |
| Ivacaftor Carboxylic Acid | Ivacaftor Carboxylic Acid. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Benzeneacetic acid, 4-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-5-(1,1-dimethylethyl)-2-hydroxy-?,?-dimethyl-, 2-(5-tert-Butyl-2-hydroxy-4-(4-oxo-1,4-dihydroquinoline-3-carboxamido)phenyl)-2-methylpropanoic acid, 4-[[(1,4-Dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-5-(1,1-dimethylethyl)-2-hydroxy-?,?-dimethylbenzeneacetic acid, Ivacaftor carboxylic acid, Ivacaftor impurity 1. CAS No. 1246213-24-0. IUPAC Name: 2-[5-tert-butyl-2-hydroxy-4-[(4-oxo-1H-quinoline-3-carbonyl)amino]phenyl]-2-methylpropanoic acid. Molecular formula: C24H26N2O5. Mole weight: 422.47. Catalog: APS1246213240. SMILES: CC(C)(C)c1cc(c(O)cc1NC(=O)C2=CNc3ccccc3C2=O)C(C)(C)C(=O)O. Format: Neat. |  |
| Ivacaftor-d18 | Ivacaftor-d18. Group: Biochemicals. Alternative Names: N-[2,4-Bis[1,1-di(methyl-d3)ethyl-2,2,2-d3]-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide-d18. Grades: Highly Purified. CAS No. 1413431-05-6. Pack Sizes: 2.5mg. Molecular Formula: C24H10D18N2O3, Molecular Weight: 410.6. US Biological Life Sciences. | Worldwide |
| Ivacaftor-[d18] | Ivacaftor-[d18] is the labelled analogue of Ivacaftor. Ivacaftor is an orally bioavailable potentiator of the cystic fibrosis transmembrane conductance regulator (CFTR) that improves chloride transport. Synonyms: Ivacaftor D18. Grade: 95% by HPLC; 95% atom D. CAS No. 1413431-05-6. Molecular formula: C24H10D18N2O3. Mole weight: 410.6. |  |
| Ivacaftor-d19 | Ivacaftor-d 9 is a potent CFTR modulator and exhibits an EC 50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research [1]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: VX-770-d19. CAS No. 1413431-22-7. Pack Sizes: 5 mg; 1 mg. Product ID: HY-13017S1. | |
| Ivacaftor impurities5 | Ivacaftor impurities5. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1246213-24-0. Molecular formula: C24H26N2O5. Mole weight: 422.48. Catalog: APB1246213240. | |
| Ivacaftor impurities6 | Ivacaftor impurities6. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1246213-23-9. Molecular formula: C24H28N2O4. Mole weight: 408.5. Catalog: APB1246213239. | |
| Ivacaftor impurities7 | Ivacaftor impurities7. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1246213-41-1. Molecular formula: C24H24N2O4. Mole weight: 404.47. Catalog: APB1246213411. | |
| Ivacaftor N-Glucuronide | Ivacaftor N-Glucuronide. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg. Molecular Formula: C30H36N2O9, Molecular Weight: 568.61. US Biological Life Sciences. | Worldwide |
| Hydroxymethyl Ivacaftor | Hydroxymethyl Ivacaftor. Uses: For analytical and research use. Group: Impurity standards. Catalog: APS001947. Format: Neat. | |
| 1,4-Dihydro-4-oxo-3-quinolinecarbonyl Chloride | 1,4-Dihydro-4-oxo-3-quinolinecarbonyl Chloride is an impurity of Ivacaftor, a drug used in the treatment of cystic fibrosis. Synonyms: 4-Oxo-1,4-dihydroquinoline-3-carbonyl Chloride. CAS No. 80761-61-1. Molecular formula: C10H6ClNO2. Mole weight: 207.61. | |
| 2,4-Di-tert-butyl-5-nitrophenyl-d10 Methyl Carbonate | 5-Nitro-2,4-bis(1,1-dimethylethyl)phenyl-carbonic Acid Methyl Ester-d10 is an intermediate used in the synthesis of Ivacaftor (4-tertbutyl-d9) (Major) (I940603), which is isotopically labeled form of Ivacaftor (I940600), that is used in the treatment of cystic fibrosis. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C16H13D10NO5, Molecular Weight: 319.42. US Biological Life Sciences. | Worldwide |
| 2,4-Di-tert-butyl-6-nitrophenyl Methyl Carbonate + 2,4-Di-tert-butyl-5-nitrophenyl Methyl Carbonate (Mixture of Regioisomers) | 2,4-Di-tert-butyl-6-nitrophenyl Methyl Carbonate + 2,4-Di-tert-butyl-5-nitrophenyl Methyl Carbonate (Mixture of Regioisomers) is an intermediate of Ivacaftor, a drug used in the treatment of cystic fibrosis. Molecular formula: C16H23NO5. Mole weight: 309.36. | |
| 2,4-Di-tert-butyl-6-nitrophenyl Methyl Carbonate + 2,4-Di-tert-butyl-5-nitrophenyl Methyl Carbonate. (Mixture of Regioisomers) | 2,4-Di-tert-butyl-6-nitrophenyl Methyl Carbonate + 2,4-Di-tert-butyl-5-nitrophenyl Methyl Carbonate (Mixture of Regioisomers) is an intermediate in the synthesis of Ivacaftor (4-tertbutyl-d9) (Major) (I940603). Ivacaftor (4-tertbutyl-d9) (Major) is isotopically labelled form of Ivacaftor (I940600), which is used in the treatment of cystic fibrosis. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 25mg. Molecular Formula: C16H23NO5 + C16H23NO5. US Biological Life Sciences. | Worldwide |
| 2,4-Di-tert-butylphenol-d10 | 2,4-Di-tert-butylphenol-d10 is an intermediate in the synthesis of Ivacaftor (4-tertbutyl-d9) (Major) (I940603). Ivacaftor (4-tertbutyl-d9) (Major) is isotopically labelled form of Ivacaftor (I940600), which is used in the treatment of cystic fibrosis. 2,4-Di-tert-butylphenol-d18 is the labelled analogue of 2,4-Di-tert-butylphenol (D429475). A chemical constituent of volatile oils from Catunaregam spinosa fruits. Group: Biochemicals. Grades: Highly Purified. CAS No. 1577233-50-1. Pack Sizes: 5mg, 10mg. Molecular Formula: C14H12D10O. US Biological Life Sciences. | Worldwide |
| 2-Bromo-4-(1,1-dimethylethyl)-5-nitrophenol | 2-Bromo-4-(1,1-dimethylethyl)-5-nitrophenol is a metabolite of Ivacaftor, a drug used in the treatment of cystic fibrosis. Synonyms: 2-Bromo-4-(2-methyl-2-propanyl)-5-nitrophenol; Phenol, 2-bromo-4-(1,1-dimethylethyl)-5-nitro-; 2-Bromo-4-tert-butyl-5-nitro-phenol. Grade: ≥95%. CAS No. 1246213-42-2. Molecular formula: C10H12BrNO3. Mole weight: 274.11. | |
| 2-Bromo-4-(1,1-dimethylethyl)-5-nitrophenyl Methyl Ester Carbonic Acid | 2-Bromo-4-(1,1-dimethylethyl)-5-nitrophenyl Methyl Ester Carbonic Acid is an intermediate in the synthesis of Ivacaftor, which is a CFTR potentiator used in the treatment of cystic fibrosis. Synonyms: 2-Bromo-4-(2-methyl-2-propanyl)-5-nitrophenyl methyl carbonate; Carbonic acid, 2-bromo-4-(1,1-dimethylethyl)-5-nitrophenyl methyl ester. Grade: ≥95%. CAS No. 1233530-92-1. Molecular formula: C12H14BrNO5. Mole weight: 332.15. | |
| 2-Bromo-4-(1,1-dimethylethyl)phenyl Methyl Ester Carbonic Acid | 2-Bromo-4-(1,1-dimethylethyl)phenyl Methyl Ester Carbonic Acid is an intermediate in the synthesis of Ivacaftor, which is a CFTR potentiator used in the treatment of cystic fibrosis. Synonyms: Carbonic acid, 2-bromo-4-(1,1-dimethylethyl)phenyl methyl ester; 2-Bromo-4-(2-methyl-2-propanyl)phenyl methyl carbonate. Grade: 98%. CAS No. 1233530-91-0. Molecular formula: C12H15BrO3. Mole weight: 287.15. | |
| 2-Bromo-4-(tert-butyl)-5-nitrophenyl Acetate | 2-Bromo-4-(tert-butyl)-5-nitrophenyl Acetate is an intermediate in the synthesis of Ivacaftor, which is a CFTR potentiator used in the treatment of cystic fibrosis. Molecular formula: C12H14BrNO4. Mole weight: 316.15. | |
| 2-Bromo-4-tert-butyl-6-nitro-phenol Acetate | 2-Bromo-4-tert-butyl-6-nitro-phenol Acetate is an impurity of Ivacaftor, which is a CFTR potentiator used in the treatment of cystic fibrosis. Synonyms: Phenol, 2-bromo-4-(1,1-dimethylethyl)-6-nitro-, acetate (ester); 2-Bromo-4-(2-methyl-2-propanyl)-6-nitrophenyl acetate. Grade: 98%. CAS No. 857629-23-3. Molecular formula: C12H14BrNO4. Mole weight: 316.15. | |
| 3-Amino-4-(1,1-dimethylethyl)-6-[1,1-di(methyl-d3)ethyl-2,2,2-d3]phen-2-d-ol | 3-Amino-4-(1,1-dimethylethyl)-6-[1,1-di(methyl-d3)ethyl-2,2,2-d3]phen-2-d-ol is an intermediate used in the synthesis of Ivacaftor (4-tertbutyl-d9) (Major) (I940603), which is isotopically labelled form of Ivacaftor (I940600), which is used in the treatment of cystic fibrosis. Group: Biochemicals. Grades: Highly Purified. CAS No. 1577233-53-4. Pack Sizes: 500ug, 1mg. Molecular Formula: C14H13D10NO, Molecular Weight: 231.4. US Biological Life Sciences. | Worldwide |
| 5-(1,1-Dimethylethyl)-2-hydroxy-α,α-dimethyl-4-nitro-benzeneacetic Acid Methyl Ester | 5-(1,1-Dimethylethyl)-2-hydroxy-α,α-dimethyl-4-nitro-benzeneacetic Acid Methyl Ester is an intermediate in the synthesis of Ivacaftor, which is a CFTR potentiator used in the treatment of cystic fibrosis. Synonyms: Methyl 2-[2-hydroxy-5-(2-methyl-2-propanyl)-4-nitrophenyl]-2-methylpropanoate; Benzeneacetic acid, 5-(1,1-dimethylethyl)-2-hydroxy-α,α-dimethyl-4-nitro-, methyl ester. CAS No. 1246213-34-2. Molecular formula: C15H21NO5. Mole weight: 295.33. | |
| 5-(1,1-Dimethylethyl)-3,3-dimethyl-6-nitro-2(3H)-benzofuranone | 5-(1,1-Dimethylethyl)-3,3-dimethyl-6-nitro-2(3H)-benzofuranone is an impurity of Ivacaftor, a drug used in the treatment of cystic fibrosis. Synonyms: 5-(tert-butyl)-3,3-dimethyl-6-nitrobenzo[b]furan-2(3H)-one. CAS No. 1246213-39-7. Molecular formula: C14H17NO4. Mole weight: 263.29. | |
| 5-Amino-2,4-di-tert-butylphenol | 5-Amino-2,4-di-tert-butylphenol is an intermediate of Ivacaftor, a drug used in the treatment of cystic fibrosis. Synonyms: 5-Amino-2,4-bis(1,1-dimethylethyl)phenol; 5-Amino-2,4-bis(2-methyl-2-propanyl)phenol; Phenol, 5-amino-2,4-bis(1,1-dimethylethyl)-. Grade: ≥95%. CAS No. 873055-58-4. Molecular formula: C14H23NO. Mole weight: 221.34. | |
| 5-Amino-2,4-di-tert-butylphenol-d9 | 5-Amino-2,4-di-tert-butylphenol-d9 is an intermediate in the synthesis of Ivacaftor (4-tertbutyl-d9) (Major) (I940603). Ivacaftor (4-tertbutyl-d9) (Major) is isotopically labelled form of Ivacaftor (I940600), which is used in the treatment of cystic fibrosis. Group: Biochemicals. Grades: Highly Purified. CAS No. 1577233-54-5. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C14H14D9NO. US Biological Life Sciences. | Worldwide |
| 6-Amino-2,4-di-tert-butylphenyl Methyl Carbonate | 6-Amino-2,4-di-tert-butylphenyl Methyl Carbonate is an intermediate of Ivacaftor, a drug used in the treatment of cystic fibrosis. Synonyms: 2-amino-4,6-di-tert-butylphenyl methyl carbonate; 2-Amino-4,6-bis(2-methyl-2-propanyl)phenyl methyl carbonate; Carbonic acid, 2-amino-4,6-bis(1,1-dimethylethyl)phenyl methyl ester. Molecular formula: C16H25NO3. Mole weight: 279.37. | |
| 6-Amino-5-(1,1-dimethylethyl)-3,3-dimethyl-2(3H)-benzofuranone | 6-Amino-5-(1,1-dimethylethyl)-3,3-dimethyl-2(3H)-benzofuranone is an intermediate in the synthesis of Ivacaftor, which is a CFTR potentiator used in the treatment of cystic fibrosis. Synonyms: 6-Amino-5-(tert-butyl)-3,3-dimethylbenzofuran-2(3H)-one; 2(3H)-Benzofuranone, 6-amino-5-(1,1-dimethylethyl)-3,3-dimethyl-; 6-Amino-3,3-dimethyl-5-(2-methyl-2-propanyl)-1-benzofuran-2(3H)-one; 6-Amino-5-(tert-butyl)-3,3-dimethylbenzo[b]furan-2(3H)-one. Grade: ≥95%. CAS No. 1246213-40-0. Molecular formula: C14H19NO2. Mole weight: 233.31. | |
| Bamocaftor | Bamocaftor, a cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore the function of F508del-CFtr protein, can be used in combination with Tezacaftor and Ivacaftor in cystic fibrosis studies. Synonyms: VX-659; (S)-N-(phenylsulfonyl)-6-(3-(2-(1-(trifluoromethyl)cyclopropyl)ethoxy)-1H-pyrazol-1-yl)-2-(2,2,4-trimethylpyrrolidin-1-yl)nicotinamide; 3-Pyridinecarboxamide, N-(phenylsulfonyl)-6-(3-(2-(1-(trifluoromethyl)cyclopropyl)ethoxy)-1H-pyrazol-1-yl)-2-((4S)-2,2,4-trimethyl-1-pyrrolidinyl)-; N-(Phenylsulfonyl)-6-(3-{2-[1-(trifluoromethyl)cyclopropyl]ethoxy}-1H-pyrazol-1-yl)-2-[(4S)-2,2,4-trimethyl-1-pyrrolidinyl]nicotinamide. Grade: ≥95%. CAS No. 2204245-48-5. Molecular formula: C28H32F3N5O4S. Mole weight: 591.64. | |
| Elexacaftor | Elexacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector used as a medication for cystic fibrosis treatment in combination with ivacaftor and tezacaftor. Synonyms: VX-445; VX445; (S)-N-((1,3-dimethyl-1H-pyrazol-4-yl)sulfonyl)-6-(3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl)-2-(2,2,4-trimethylpyrrolidin-1-yl)nicotinamide. Grade: 98%. CAS No. 2216712-66-0. Molecular formula: C26H34F3N7O4S. Mole weight: 597.65. | |
| Tezacaftor | Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VX-661. CAS No. 1152311-62-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-15448. | |
| VX-561 | VX-561, also known as d9-ivacaftor, is an agonist of cystic fibrosis transmembrane conductance regulator (CFTR) channel developed for the treatment of cystic fibrosis. VX-561 is in a phase II clinical trial for safety and efficacy evaluation. Uses: Potential treatment of cystic fibrosis. Synonyms: CTP-656; N-(2-(tert-butyl)-5-hydroxy-4-(2-(methyl-d3)propan-2-yl-1,1,1,3,3,3-d6)phenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide; d9-ivacaftor. CAS No. 1413431-07-8. Molecular formula: C24H19D9N2O3. Mole weight: 401.55. | |
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