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| Product | Description | |
|---|---|---|
| Leflunomide | 100mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C12H9F3N2O2. CAS No. 75706-12-6. Prepack ID 77117657-100mg. Molecular Weight 270.21. See USA prepack pricing. |  |
| Leflunomide | Leflunomide. Group: Biochemicals. Grades: Purified. CAS No. 75706-12-6. Pack Sizes: 50mg. US Biological Life Sciences. |  Worldwide |
| Leflunomide | Leflunomide inhibits the reproduction of rapidly dividing cells by inhbiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH). Synonyms: Leflunomide, Arava, Leflunomidum, HWA-486; HWA486; HWA 486. Grade: >98%. CAS No. 75706-12-6. Molecular formula: C12H9F3N2O2. Mole weight: 270.21. |  |
| Leflunomide | Leflunomide is a pyrimidine synthesis inhibitor, inhibiting dihydroorotate dehydrogenase (DHODH), and acts as a disease-modifying antirheumatic agent. Uses: Scientific research. Group: Natural products. Alternative Names: HWA486; RS-34821; SU101. CAS No. 75706-12-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0083. |  |
| Leflunomide 3-isomer | Leflunomide 3-isomer. Group: Biochemicals. Alternative Names: 5-Methyl-N-[3- (trifluoromethyl) phenyl]-4-isoxazolecarboxamide; Leflunomide imp. E (EP). Grades: Highly Purified. CAS No. 61643-23-0. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C12H9F3N2O2. US Biological Life Sciences. | Worldwide |
| Leflunomide (5- methyl isoxazole-4- [4-trifluoro methyl carboxanilide] ) | An immunosuppressive. Group: Biochemicals. Alternative Names: 5- methyl isoxazole-4- [4-trifluoro methyl carboxanilide] . Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Leflunomide-[d4] | Leflunomide-[d4] is an isotope form of Leflunomide. Leflunomide inhibits the reproduction of rapidly dividing cells by inhbiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH). Synonyms: Leflunomide-d4; 5-Methylisoxazole-4-[4-trifluoromethylcarboxanilide]-d4; Leflunomida-d4; 5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide-d4; Leflunomidum-d4. Grade: 95% by HPLC; 95% atom D. CAS No. 1189987-23-2. Molecular formula: C12H5D4F3N2O2. Mole weight: 274.23. | |
| Leflunomide-d4 (5- methyl isoxazole-4- [4-trifluoro methyl carboxanilide] -d4) | An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Group: Biochemicals. Alternative Names: 5- methyl isoxazole-4- [4-trifluoro methyl carboxanilide] -d4. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Leflunomide Related Compound A | Pharmaceutical Secondary Standard; Certified Reference Material. Group: Pharmacopeia & metrological institutes standards. |  |
| Leflunomide Related Compound A | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Leflunomide Related Compound B | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Leflunomide Related Compound C | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| 5-Desmethyl-3-methyl leflunomide | 5-Desmethyl-3-methyl leflunomide. Group: Biochemicals. Alternative Names: 3-Methyl-N-[4- (trifluoromethyl) phenyl]-4-isoxazolecarboxamide; N-[4- (Trifluoromethyl) phenyl]-3-methylisoxazole-4-carboxamide. Grades: Highly Purified. CAS No. 208401-20-1. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C12H9F3N2O2. US Biological Life Sciences. | Worldwide |
| 5-Desmethyl-3-methyl leflunomide | 5-Desmethyl-3-methyl leflunomide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide; N-[4-(Trifluoromethyl)phenyl]-3-methylisoxazole-4-carboxamide. Product Category: Heterocyclic Organic Compound. CAS No. 208401-20-1. Molecular formula: C12H9F3N2O2. Mole weight: 270.21. Purity: 0.96. IUPACName: 3-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide. Canonical SMILES: CC1=NOC=C1C(=O)NC2=CC=C(C=C2)C(F)(F)F. Product ID: ACM208401201. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 2-Cyano-3-hydroxy-N-(4-methylphenyl)-2-butenamide | 2-Cyano-3-hydroxy-N-(4-methylphenyl)-2-butenamide is an impurity of Teriflunomide (A771726) which is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. Group: Biochemicals. Grades: Highly Purified. CAS No. 1385789-70-7. Pack Sizes: 10mg, 25mg. Molecular Formula: C12H12N2O2, Molecular Weight: 216.24. US Biological Life Sciences. | Worldwide |
| 2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)crotonamide | 2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)crotonamide is the active metabolite of leflunomide, which is a pyrimidine synthesis inhibitor used as an immunomodulatory agent and antirheumatic agent. Synonyms: 2-Butenamide, 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-; 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide. Grade: >98%. CAS No. 108605-62-5. Molecular formula: C12H9F3N2O2. Mole weight: 270.21. | |
| 2-Cyano-N-[3-methyl-4- (trifluoromethyl) phenyl]-acetamide | 2-Cyano-N-[3-methyl-4- (trifluoromethyl) phenyl]-acetamide is used to synhesize analogues of leflunomide active metabolite with antiarthritic potential. Group: Biochemicals. Grades: Highly Purified. CAS No. 179637-55-9. Pack Sizes: 500mg, 5g. Molecular Formula: C11H9F3N2O, Molecular Weight: 242.2. US Biological Life Sciences. | Worldwide |
| 2-Cyano-N-[4- (trifluoromethyl) phenyl]acetamide | 2-Cyano-N-[4- (trifluoromethyl) phenyl]acetamide (Leflunomide EP Impurity H) is used to prepare aminothiophene carboxylates and carboxamides as adenosine A1 receptor allosteric enhancers. It is also used to synthesize (1,2,3-triazol-4-yl)benzenamines as inhibitors against VEGF receptors 1 and 2. Group: Biochemicals. Grades: Highly Purified. CAS No. 24522-30-3. Pack Sizes: 1g, 10g. Molecular Formula: C10H7F3N2O. US Biological Life Sciences. | Worldwide |
| 2-Cyano-N-[4-(Trifluoromethyl)Phenyl]Acetamide | Leflunomide Impurity H is used to prepare aminothiophene carboxylates and carboxamides as adenosine A1 receptor allosteric enhancers. Synonyms: 2-Cyano-α,α,α-trifluoro-p-acetotoluidide; Leflunomide EP Impurity H; Acetamide, 2-cyano-N-[4-(trifluoromethyl)phenyl]-; N-(4-trifluoromethylphenyl)cyanoacetamide; p-Acetotoluidide, 2-cyano-alpha,alpha,alpha-trifluoro-. Grade: >95%. CAS No. 24522-30-3. Molecular formula: C10H7F3N2O. Mole weight: 228.18. | |
| (2Z)-2-Cyano-N-(4-cyanophenyl)-3-hydroxy-2-Butenamide | (2Z)-2-Cyano-N-(4-cyanophenyl)-3-hydroxy-2-Butenamide was used in the study of structural requirements for bioactive mtabolites of leflunomide. Group: Biochemicals. Grades: Highly Purified. CAS No. 202057-74-7. Pack Sizes: 1mg, 5mg. Molecular Formula: C12H9N3O2, Molecular Weight: 227.22. US Biological Life Sciences. | Worldwide |
| 5-Methylisoxazole-3-carboxylic-d4 Acid | A labelled metabolite of UTL-5b, a structural analog of the anti-arthritic drug, Leflunomide (L322750). Group: Biochemicals. Alternative Names: 5-(Methyl-d3)-3-isoxazole-4-d-carboxylic Acid; 3-Carboxy-5-methylisoxazole-d4; 5-Methyl-3-isoxazolecarboxylic-d4 Acid. Grades: Highly Purified. CAS No. 1267623-84-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 5-Methylisoxazole-4-carboxylic Acid | An intermediate for synthesis of Leflunomide. Herbicidal activities towards Digitaria ciliaris. Group: Biochemicals. Alternative Names: 5-Methyl-4-isoxazolecarboxylic Acid. Grades: Highly Purified. CAS No. 42831-50-5. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| 5-Methyl-N-[4- (trifluoromethyl) phenyl]isoxazole-4- carboxamide | 5-Methyl-N-[4- (trifluoromethyl) phenyl]isoxazole-4- carboxamide. Group: Biochemicals. Alternative Names: Leflunomide. Grades: Highly Purified. CAS No. 75706-12-6. Pack Sizes: 50g, 100g, 250g, 500g, 1kg. Molecular Formula: C12H9F3N2O2. US Biological Life Sciences. | Worldwide |
| A77 1726-d4 (N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide-d4, 2-Cyano-3-hydroxy-N-[4- (trifluoromethyl) phenyl]-2-beuteamide-d4, LEF-M-d4) | The active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. Group: Biochemicals. Alternative Names: N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide-d4, 2-Cyano-3-hydroxy-N-[4- (trifluoromethyl) phenyl]-2-beuteamide-d4, LEF-M-d4. Grades: Highly Purified. CAS No. 1185240-22-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| A77 1726 (N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide, 2-Cyano-3-hydroxy-N-[4- (trifluoromethyl) phenyl]-2-beuteamide, LEF-M) | The active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. Group: Biochemicals. Alternative Names: N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide, 2-Cyano-3-hydroxy-N-[4- (trifluoromethyl) phenyl]-2-beuteamide, LEF-M. Grades: Highly Purified. CAS No. 163451-81-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| A77 1726, (N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide, 2-Cyano-3-hydroxy-N-[4- (trifluoromethyl) phenyl]-2-butenamide) | Physiologically active metabolite of the immunosuppressive drug leflunomide. Inhibits the activity of dihydrorotate dehydrogenase and of protein tyrosine kinases. Blocks TNF-mediated NF-kB activation in a dose- and time-dependent manner. Also inhibits the activity of COX-2 in vitro and in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| DHODH-IN-12 | DHODH-IN-12, a leflunomide derivative, is a weak inhibitor of dihydroorotate dehydrogenase (DHODH) with a pKa of 5.07. Synonyms: (2E)-2-cyano-2-(hydroxyimino)-N-(4-methylphenyl)ethanamide; Acetamide, 2-cyano-2-(hydroxyimino)-N-(4-methylphenyl)-, (2E)-. Grade: ≥95%. CAS No. 1263303-93-0. Molecular formula: C10H9N3O2. Mole weight: 203.20. | |
| Ethyl 3-methylisoxazole-4-carboxylate | an impurity in Leflunomide. Synonyms: 3-Methylisoxazole-4-carboxylic Acid Ethyl Ester. Grade: > 95%. CAS No. 20328-15-8. Molecular formula: C7H9NO3. Mole weight: 155.15. | |
| hDHODH-IN-2 | hDHODH-IN-2, an analogue of the active metabolite of Leflunomide, is an inhibitor of human dihydroorotate dehydrogenase (hDHODH) with anti-inflammatory activity. Synonyms: (2Z)-N-biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enamide; (2Z)-N-(4-Biphenylyl)-2-cyano-3-cyclopropyl-3-hydroxyacrylamide; 2-Propenamide, N-[1,1'-biphenyl]-4-yl-2-cyano-3-cyclopropyl-3-hydroxy-, (2Z)-; (Z)-N-Biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide; (Z)-N-([1,1'-biphenyl]-4-yl)-2-cyano-3-cyclopropyl-3-hydroxyacrylamide. Grade: ≥95%. CAS No. 183946-00-1. Molecular formula: C19H16N2O2. Mole weight: 304.34. | |
| PfDHODH-IN-1 | PfDHODH-IN-1 is an analogue of the active metabolite of Leflunomide. PfDHODH-IN-1 is a Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor. PfDHODH-IN-1 has antimalarial activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 183945-55-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135648. | |
| Teriflunomide | Teriflunomide is the active metabolite of leflunomide, an approved therapy for rheumatoid arthritis. It inhibits pyrimidine synthesis and therefore potently decreases T cell and B cell proliferation. Uses: Scientific research. Group: Signaling pathways. Alternative Names: A77 1726. CAS No. 163451-81-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-15405. | |
| Teriflunomide | Teriflunomide, the active metabolite of leflunomide, is an immunomodulatory drug inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase. It inhibits rapidly dividing cells, including activated T cells, and tyrosine kinase enzymes. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: Leflunomide Impurity B; A77 1726; A771726; A77-1726; HMR1726; HMR-1726; HMR 1726; N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide; 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-beuteamide; LEF-M; Leflunomide EP Impurity B; Aubagio; (2Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide; Femorix. Grade: >98%. CAS No. 163451-81-8. Molecular formula: C12H9F3N2O2. Mole weight: 270.21. | |
| Teriflunomide-[d4] | The active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. Synonyms: Leflunomide-d4 Metabolite; N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide-d4; 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-beuteamide-d4. Grade: > 95%. CAS No. 1185240-22-5. Molecular formula: C12H5F3N2O2D4. Mole weight: 274.24. | |
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