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Acetyl-D-leucine. Synonyms: Ac-D-Leu-OH; (R)-Ac-2-amino-4-methylpentanoic acid. Grade: ≥ 99% (Assay by titration). CAS No. 19764-30-8. Molecular formula: C8H15NO3. Mole weight: 173.20.
Acetyl-D-leucine 99+%
Acetyl-D-leucine 99+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g, 100g. US Biological Life Sciences.
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Acetyl-DL-leucine
Acetyl-DL-leucine. Group: Biochemicals. Alternative Names: Ac-DL-Leu-OH; (RS)-Ac-2-amino-4-methyl-pentanoic acid. Grades: Highly Purified. CAS No. 99-15-0. Pack Sizes: 50g, 100g, 250g, 500g, 1kg. US Biological Life Sciences.
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Acetyl-DL-leucine 99+%
Acetyl-DL-leucine 99+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 25g, 100g, 250g, 1Kg. US Biological Life Sciences.
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Acetylleucine
Acetylleucine (N-Acetyl-DL-leucine), orally active compound, can be used for the research of acute vestibular vertigo, cerebellar ataxia and nystagmus [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N-Acetyl-DL-leucine. CAS No. 99-15-0. Pack Sizes: 10 mM * 1 mL; 5 g; 10 g. Product ID: HY-B1442.
Acetyl-L-leucine methyl ester 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g, 100g. US Biological Life Sciences.
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Indole-3-acetyl-l-leucine
Indole-3-acetyl-l-leucine. Group: Biochemicals. Alternative Names: N-(3indolylacetyl)-L-leucine. Grades: Highly Purified. CAS No. 36838-63-8. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C16H20N2O3. US Biological Life Sciences.
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leucine N-acetyltransferase
Propanoyl-CoA can act as a donor, but more slowly. L-Arginine, L-valine, L-phenylalanine and peptides containing L-leucine can act as acceptors. Group: Enzymes. Synonyms: leucine acetyltransferase. Enzyme Commission Number: EC 2.3.1.66. CAS No. 75496-56-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2246; leucine N-acetyltransferase; EC 2.3.1.66; 75496-56-9; leucine acetyltransferase. Cat No: EXWM-2246.
Levacetylleucine
Levacetylleucine, an orally bioavailable and brain-penetrant endogenous metabolite, is an acetylated derivative of amino acid leucine. Levacetylleucine is the active form of N-acetyl-leucine (NAL). Levacetylleucine attenuates neuronal death and neuroinflammation in the cortical tissue of mice. Levacetylleucine also potentially improves ameliorates lysosomal and metabolic dysfunction. Levacetylleucine improves compensation of postural symptoms after unilateral chemical labyrinthectomy (UL) in rats. Levacetylleucine is promising for research of neurological manifestations of Niemann-Pick disease type C, traumatic brain injury and neurodegeneration prevention [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 1188-21-2. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-59291.
N-Acetyl-DL-leucine
100g Pack Size. Group: Amino Acids. Formula: C8H15NO3. CAS No. 99-15-0. Prepack ID 73891210-100g. Molecular Weight 173.21. See USA prepack pricing.
N-Acetyl-DL-leucine
25g Pack Size. Group: Amino Acids. Formula: C8H15NO3. CAS No. 99-15-0. Prepack ID 73891210-25g. Molecular Weight 173.21. See USA prepack pricing.
N-Acetyl-DL-Leucine
Used for treating vestibular-related imbalance and vertigo. Alternative Names: N-Acetyl-DL-leucine. Acetylleucine. Ac-DL-Leu-OH. 2-acetamido-4-methylpentanoic acid. CAS No. 99-15-0. Product ID: PIPB-0772. Molecular formula: C8H15NO3. Mole weight: 173.21. EINECS: 202-734-9. SMILES: CC(C)CC(C(=O)O)NC(=O)C. Appearance: White crystals or crystalline powder. Category: Peptide APIs.
N-Acetyl-L-leucine
25g Pack Size. Group: Amino Acids. Formula: C8H15NO3. CAS No. 1188-21-2. Prepack ID 14001186-25g. Molecular Weight 173.21. See USA prepack pricing.
N-Acetyl-L-leucine. Group: Biochemicals. Alternative Names: Ac-Leu-OH. Grades: Highly Purified. CAS No. 1188-21-2. Pack Sizes: 100g, 250g, 500g, 1kg, 2kg. Molecular Formula: C8H15NO3. US Biological Life Sciences.
Worldwide
N-Acetyl-L-leucine
N-Acetyl-L-leucine is used in the preparation of small molecule inhibitors of anti-apoptotic Bcl-2 family proteins. It is used in the preparation of amphiphilic copolymers involving hydrophobic amino acid and oligopeptide side chains for optical tumor imaging in vivo. Alternative Names: AKOS BBS-00004735;ACETYL-DL-LEUCINE, N-;ACETYL-DL-LEUCINE;ACETYL-L-LEUCINE;AC-DL-LEU-OH;AC-LEUCINE;AC-LEU-OH;IFLAB-BB F0777-0821. CAS No. 1188-21-2. Product ID: PIPB-0167. Molecular formula: C8H15NO3. Mole weight: 173.21. EINECS: 214-706-3. SMILES: CC(C)C[C@@H](C(=O)O)NC(=O)C. Appearance: Crystalline Powder. Category: Peptide.
N-Acetyl-L-Leucine
N-acetyl-L-leucine is the N-acetyl derivative of L-leucine. It has a role as a metabolite. It is a N-acetyl-L-amino acid and a L-leucine derivative. It is a conjugate acid of a N-acetyl-L-leucinate. It is an enantiomer of a N-acetyl-D-leucine. CAS No. 1188-21-2. Product ID: PAP-0012. Molecular formula: C8H15NO3. Category: Amino acid. Product Keywords: Amino Acid Series; N-Acetyl-L-Leucine; PAP-0012; Amino acid; C8H15NO3; 1188-21-2. Color: White. EC Number: 214-706-3. Physical State: Crystalline Powder. Solubility: DMSO (Slightly), Ethanol (Slightly), Water (Slightly, Heated). Storage: Sealed in dry,Room Temperature. Applications: N-Acetyl-L-Leucine is an important fine organic chemical intermediate, widely used in medicine, pesticides, chemical industry and other fields. Boiling Point: 303.86°C (rough estimate). Melting Point: 187-190 °C(lit.). Density: 1.1599 (rough estimate). Product Description: N-Acetyl-L-Leucine is an important fine organic chemical intermediate, widely used in medicine, pesticides, chemical industry and other fields.
N-Acetyl-L-leucine-[d10]
N-Acetyl-L-leucine-[d10] is a labelled N-acetyl-L-Leucine. N-acetyl-L-Leucine is a derivative of leucine and is used as a drug for the treatment of vertigo. Synonyms: N-Acetyl-L-leucine d10. Grade: 98% by CP; 98% atom D. Molecular formula: C8H5D10NO3. Mole weight: 183.3.
(S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine N-acetyl-L-leucine salt
(S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine N-acetyl-L-leucine salt is a highly potent biomedical substance, standing as a notable instrument in the research against a multitude of diseases. Its efficacy in studying cancer, inflammation and neurodegenerative disorders remains profound. Synonyms: (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine (S)-2-acetamido-4-methylpentanoate; (S)-2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulphonyl)-eth-2-ylamine N-acetyl-L-leucine salt; (1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonyl-ethylamine n-acetyl-L-leucine salt. Grade: 95%. CAS No. 608141-43-1. Molecular formula: C12H19NO4S.C8H15NO3. Mole weight: 446.56.
Acetylleucine is a drug mianly used to treat the vertigo.It has been listed. Uses: Acetylleucine is used to treat the vertigo. Synonyms: Acetylleucine; N-Acetyl-DL-leucine; DL-Leucine,N-acetyl-; Acetyl-DL-leucine; Tanganil; 2-Acetamido-4-methylpentanoic acid. Grade: >98 %. CAS No. 99-15-0. Molecular formula: C8H15NO3. Mole weight: 173.21.
acetyl-CoA C-acetyltransferase
This enzyme participates in 10 metabolic pathways: fatty acid metabolism, synthesis and degradation of ketone bodies, valine, leucine and isoleucine degradation, lysine degradation, tryptophan metabolism, pyruvate metabolism, benzoate degradation via coa ligation, propanoate metabolism, butanoate metabolism, and two-component system-general. Group: Enzymes. Synonyms: acetoacetyl-CoA thiolase; β-acetoacetyl coenzyme A thiolase; 2-methylacetoacetyl-CoA thiolase [misleading]; 3-oxothiolase; acetyl coenzyme A thiolase; acetyl-CoA acetyltransferase; acetyl-CoA:N-acetyltransferase; thiolase II. Enzyme Commission Number: EC 2.3.1.9. CAS No. 9027-46-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2271; acetyl-CoA C-acetyltransferase; EC 2.3.1.9; 9027-46-7; acetoacetyl-CoA thiolase; β-acetoacetyl coenzyme A thiolase; 2-methylacetoacetyl-CoA thiolase [misleading]; 3-oxothiolase; acetyl coenzyme A thiolase; acetyl-CoA acetyltransferase; acetyl-CoA:N-acetyltransferase; thiolase II. Cat No: EXWM-2271.
Acetyl-Heme-Binding Protein 1 (1-21) (human)
Acetyl-Heme-Binding Protein 1 (1-21) (human), an acetylated peptide corresponding to the N-terminal fragment of human heme-binding protein, specifically promotes calcium mobilization and chemotaxis in dendritic cells and monocytes via the FPR-like receptor 2 (FPRL 2). In neutrophils, it inhibits FPR and FPRL1-mediated signaling. Synonyms: F2L; Ac-Met-Leu-Gly-Met-Ile-Lys-Asn-Ser-Leu-Phe-Gly-Ser-Val-Glu-Thr-Trp-Pro-Trp-Gln-Val-Leu-OH; N-acetyl-L-methionyl-L-leucyl-glycyl-L-methionyl-L-isoleucyl-L-lysyl-L-asparagyl-L-seryl-L-leucyl-L-phenylalanyl-glycyl-L-seryl-L-valyl-L-alpha-glutamyl-L-threonyl-L-tryptophyl-L-prolyl-L-tryptophyl-L-glutaminyl-L-valyl-L-leucine. Grade: ≥95%. CAS No. 946571-77-3. Molecular formula: C116H176N26O30S2. Mole weight: 2478.96.
Acetyl Tetrapeptide-11
Acetyl Tetrapeptide-11 is an ingredient used in anti-aging cosmetics. Synonyms: Ac-Pro-Pro-Tyr-Leu-OH; [acetyl]-PPYL-OH; N-acetyl-L-prolyl-L-prolyl-L-tyrosyl-L-leucine. Grade: 98%. CAS No. 928006-88-6. Molecular formula: C27H38N4O7. Mole weight: 530.61.
Ac-gly-leu-oh
Ac-gly-leu-oh. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N-ACETYL-GLY-L-LEU;AC-GLY-LEU-OH;ACETYL-GLYCYLLEUCINE;ACETYL-L-GLYCYL LEUCINE. Product Category: Heterocyclic Organic Compound. CAS No. 29852-55-9. Molecular formula: C10H18N2O4. Mole weight: 230.26. Product ID: ACM29852559. Alfa Chemistry ISO 9001:2015 Certified. Categories: N-ACETYLGLYCYL-L-LEUCINE.
Cyclosporin AM 4N Acetate
Cyclosporin AM 4N Acetate is an impurity of cyclosporin, which is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Synonyms: O-Acetyl-9-L-leucinecyclosporin A; O-Acetyl-cyclosporin A Metabolite 21. Grade: ≥95%. Molecular formula: C63H111N11O13. Mole weight: 1230.62.
(d-Ala2,d-leu5)-enkephalin
(d-Ala2,d-leu5)-enkephalin. Uses: Designed for use in research and industrial production. Additional or Alternative Names: YAGFL;TYR-D-ALA-GLY-PHE-D-LEU;TYR-D-ALA-GLY-PHE-D-LEU ACOH H2O;H-TYR-D-ALA-GLY-PHE-D-LEU-OH;(D-ALA2,D-LEU5)-ENKEPHALIN;[D-ALA2,D-LEU5]-ENKEPHALIN ACOH H2O;DADLE;Enkephalin, Leucine-2-Alanine. Product Category: Heterocyclic Organic Compound. CAS No. 63631-40-3. Molecular formula: C29H39N5O7. Mole weight: 569.65. Purity: 0.96. IUPACName: 2-[[2-[[2-[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoylamino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid. Canonical SMILES: CC(C)CC(C(=O)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)CNC(=O)C(C)NC(=O)C(CC2=CC=C(C=C2)O)N. Product ID: ACM63631403. Alfa Chemistry ISO 9001:2015 Certified.
[D-Ala2]-Leucine enkephalin
[D-Ala2]-Leucine enkephalin is a delta opioid agonist used to study the signaling pathway of delta opioid receptors. It inhibits the release of acetylcholine and inhibits muscle contraction. Synonyms: L-Leucine, N-[N-[N-(N-L-tyrosyl-D-alanyl)glycyl]-L-phenylalanyl]-; L-Tyrosyl-D-alanylglycyl-L-phenylalanyl-L-leucine; 1-5-(D-Ala2)-dynorphin; 2-D-Alanine-5-leucine-enkephalin; [D-Ala2]leucine-enkephalin; H-Tyr-D-Ala-Gly-Phe-Leu-OH; Leuphasyl; NSC 374895; Pentapeptide 18; Tyr-D-Ala-Gly-Phe-Leu; Tyr-D-Ala-Gly-Phe-Leu-OH; Tyrosyl-D-alanylglycylphenylalanylleucine. CAS No. 64963-01-5. Molecular formula: C29H39N5O7. Mole weight: 569.65.
Fa-gly-leu-nh2
Fa-gly-leu-nh2. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (3-[2-FURYL]ACRYLOYL)-GLY-LEU AMIDE;3-(2-FURYL)ACRYLOYL-GLY-LEU-NH2;3-(2-FURYLACRYLOYL)-GLY-L-LEU NH2;FAGLA;FA-GLY-LEU-NH2;N-(3-[2-FURYL]ACRYLOYL)-GLY-LEU AMIDE;N-[3-(2-furyl)acryloyl]-glycine-leucine amide. Product Category: Heterocyclic Organic Compound. CAS No. 26400-33-9. Molecular formula: C15H21N3O4. Mole weight: 307.34. Purity: 0.96. IUPACName: 2-[[2-[3-(furan-2-yl)prop-2-enoylamino]acetyl]amino]-4-methylpentanamide. Canonical SMILES: CC(C)CC(C(=O)N)NC(=O)CNC(=O)C=CC1=CC=CO1. Density: 1.188g/cm³. Product ID: ACM26400339. Alfa Chemistry ISO 9001:2015 Certified.
H-Gly-leu-gly-leu-oh
H-Gly-leu-gly-leu-oh. Uses: Designed for use in research and industrial production. Additional or Alternative Names: GLYCYL-L-LEUCYL-GLYCYL-L-LEUCINE;H-GLY-LEU-GLY-LEU-OH. Product Category: Heterocyclic Organic Compound. CAS No. 53843-92-8. Molecular formula: C16H30N4O5. Mole weight: 358.43. Purity: 0.96. IUPACName: 2-[[2-[[2-[(2-aminoacetyl)amino]-4-methylpentanoyl]amino]acetyl]amino]-4-methylpentanoic acid. Density: 1.155g/cm³. Product ID: ACM53843928. Alfa Chemistry ISO 9001:2015 Certified.
L-Leucine,l-tyrosyl-D-alanylglycyl-L-phenylalanyl-. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Tyr-D-Ala-Gly-Phe-Leu-OH; H-TYR-D-ALA-GLY-PHE-LEU-OH; TYR-D-ALA-GLY-PHE-LEU; D-ALA2-LEU5-ENKEPHALIN; L-Tyr-D-Ala-Gly-L-Phe-L-Leu-OH; (D-ALA2)-LEU-ENKEPHALIN; D-Ala(2)-Leu(5)-Enk; N-[N-[N-(N-L-tyrosyl-D-alanyl)glycyl]-L-phenylalanyl]-L-leucine; D-Ala2,D-Le. Product Category: Heterocyclic Organic Compound. CAS No. 64963-01-5. Molecular formula: C29H39N5O7. Mole weight: 569.6493. Purity: 0.96. IUPACName: 2-[[2-[[2-[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoylamino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid. Density: 1.257 g/cm³. Product ID: ACM64963015. Alfa Chemistry ISO 9001:2015 Certified.
Mca-PL
Mca-PL is a fluorogenic peptide that can be used in the synthesis of Mca-PLGL-Dpa-AR-NH2, a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) and MMP-7. Synonyms: Matrix Metalloproteinase-2/Matrix Metalloproteinase-7 Fluorogenic Substrate Control; Mca-Pro-Leu-OH; MMP-2/MMP-7 Fluorogenic Substrate Control; N-[1-[(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-prolyl]-L-leucine. Grade: ≥95%. CAS No. 140430-55-3. Molecular formula: C23H28N2O7. Mole weight: 444.48.
Myelin Basic Protein MBP
Myelin basic protein MBP is the second most abundant protein in the central nervous system myelin and is responsible for the adhesion of the cytosolic surfaces of multilayered compact myelin. Synonyms: Myelin Basic Protein (4-14); MBP(4-14) bovine; Myelin Basic Protein Fragment 4-14; L-Leucine, L-glutaminyl-L-Lysyl-L-arginyl-L-prolyl-L-seryl-L-glutaminyl-L-arginyl-L-seryl-L-lysyl-L-tyrosyl-; H-Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu-OH; Myelin basic protein (4-14), N-acetylated. Grade: ≥95%. CAS No. 126768-94-3. Molecular formula: C60H103N21O17. Mole weight: 1390.59.
The enzyme was originally characterized from bacteria that produce the tripeptides bialaphos and phosalacine, which inhibit plant and bacterial glutamine synthetases. It is a radical S-adenosyl-L-methionine (SAM) enzyme that contains a [4Fe-4S] center and a methylcob(III)alamin cofactor. According to the proposed mechanism, the reduced iron-sulfur center donates an electron to SAM, resulting in homolytic cleavage of the carbon-sulfur bond to form a 5'-deoxyadenosyl radical that abstracts the hydrogen atom from the P-H bond of the substrate, forming a phosphinate-centered radical. This radical reacts with methylcob(III)alamin to produce the methylated product and cob...hosphinothricin-L-alanyl-L-alanine or N-acetyl-demethylphosphinothricin-L-alanyl-L-leucine, the intermediates in the biosynthesis of bialaphos and phosalacine, respectively. This transformation produces the only example of a carbon-phosphorus-carbon linkage known to occur in nature. Group: Enzymes. Synonyms: phpK (gene name); bcpD (gene name); P-methylase. Enzyme Commission Number: EC 2.1.1.326. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1934; N-acetyldemethylphosphinothricin P-methyltransferase; EC 2.1.1.326; phpK (gene name); bcpD (gene name); P-methylase. Cat No: EXWM-1934.
N-Acetyl-L-Val-L-Leu-[13C11,15N] trifluoroacetate salt
N-Acetyl-L-Val-L-Leu-[13C11,15N] trifluoroacetate salt. Synonyms: N-Acetyl-L-Val-13C5,15N-L-Leu-13C6 trifluoroacetate salt; N-acetyl-L-valyl-L-leucine-13C11,15N trifluoroacetic acid; Ac-Val-Leu-OH-13C11,15N TFA. Grade: ≥97% by CP; 99% atom 13C; 99% atom 15N. Molecular formula: C2[13C]11H24N[15N]O4.CF3COOH. Mole weight: 398.28.
N-terminally acetylated Leu-enkephalin
N-terminally acetylated Leu-enkephalin is the N-terminally acetylated form of Leu-enkephalin, a five amino acid endogenous peptide that acts as an agonist at opioid receptors. Synonyms: H-Tyr(Ac)-Gly-Gly-Phe-Leu-OH; Ac-YGGFL; O4-acetyl-L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucine; ((S)-3-(4-acetoxyphenyl)-2-aminopropanoyl)glycylglycyl-L-phenylalanyl-L-leucine. Grade: 99%. CAS No. 2703746-32-9. Molecular formula: C30H39N5O8. Mole weight: 597.66.
opine dehydrogenase
In the forward direction, the enzyme from Arthrobacter sp. acts also on secondary amine dicarboxylates such as N-(1-carboxyethyl)methionine and N-(1-carboxyethyl)phenylalanine. Dehydrogenation forms an imine, which dissociates to the amino acid and pyruvate. In the reverse direction, the enzyme acts also on neutral amino acids as an amino donor. They include L-amino acids such as 2-aminopentanoic acid, 2-aminobutyric acid, 2-aminohexanoic acid, 3-chloroalanine, O-acetylserine, methionine, isoleucine, valine, phenylalanine, leucine and alanine. The amino acceptors include 2-oxoacids such as pyruvate, oxaloacetate, glyoxylate and 2-oxobutyrate. Group: Enzymes. Synonyms: (2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate dehydrogenase (NAD+, L-aminopentanoate-forming). Enzyme Commission Number: EC 1.5.1.28. CAS No. 108281-02-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1510; opine dehydrogenase; EC 1.5.1.28; 108281-02-3; (2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate dehydrogenase (NAD+, L-aminopentanoate-forming). Cat No: EXWM-1510.
Verrucofortine
A diketopiperazine alkaloid derived from tryptophan and leucine. It is a fungal metabolite isolated from penicillium verrucosum. It exhibits no apparent toxicity in mice even at high doses in vivo. Synonyms: Fructigenine B; Verrucosine; Verrucozine; (-)-Verrucofortine; (3S-(3alpha,5aalpha,10balpha,11abeta))-6-Acetyl-10b-(1,1-dimethyl-2-propenyl)-6,10b,11,11a-tetrahydro-3-(2-methylpropyl)-2H-pyrazino(1',2':1,5)pyrrolo(2,3-b)indole-1,4-(3H,5aH)-dione; (3S,5aR,10bR,11aS)-6-acetyl-10b-(1,1-dimethyl-2-propen-1-yl)-6,10b,11,11a-tetrahydro-3-(2-methylpropyl)-2H-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione. Grade: >99% by HPLC. CAS No. 113706-21-1. Molecular formula: C24H31N3O3. Mole weight: 409.52.
Xaa-methyl-His dipeptidase
This enzyme catalyses the following chemical reaction: hydrolysis of anserine (beta-alanyl-Npi-methyl-L-histidine), carnosine, homocarnosine, glycyl-leucine and other dipeptides with broad specificity. Group: Enzymes. Synonyms: anserinase; aminoacyl-methylhistidine dipeptidase; acetylhistidine deacetylase; N-acetylhistidine deacetylase; α-N-acetyl-L-histidine aminohydrolase; X-methyl-His dipeptidase. Enzyme Commission Number: EC 3.4.13.5. CAS No. 9027-38-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4038; Xaa-methyl-His dipeptidase; EC 3.4.13.5; 9027-38-7; anserinase; aminoacyl-methylhistidine dipeptidase; acetylhistidine deacetylase; N-acetylhistidine deacetylase; α-N-acetyl-L-histidine aminohydrolase; X-methyl-His dipeptidase. Cat No: EXWM-4038.
Acetyl-Tau Peptide (273-284) amide
Tau (273-284) forms homooligomers and heterooligomers with Aβ (25-35). Synonyms: Ac-Gly-Lys-Val-Gln-Ile-Ile-Asn-Lys-Lys-Leu-Asp-Leu-NH2; L-Leucinamide, N-acetylglycyl-L-lysyl-L-valyl-L-glutaminyl-L-isoleucyl-L-isoleucyl-L-asparaginyl-L-lysyl-L-lysyl-L-leucyl-L-α-aspartyl-. Grade: ≥95%. CAS No. 1684399-52-7. Molecular formula: C64H116N18O17. Mole weight: 1409.74.
AF 12198
It is a potent, selective human type I IL-1 receptor antagonist. Synonyms: N-Acetyl-L-phenylalanyl-L-α-glutamyl-L-tryptophyl-L-threonyl-L-prolylglycyl-L-tryptophyl-L-tyrosyl-L-glutaminyl-(2S)-2-azetidinecarbonyl-L-tyrosyl-L-alanyl-L-leucyl-L-prolyl-L-Leucinamide; Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-L-azetidine-2-carbonyl-Tyr-Ala-Leu-Pro-Leu-NH2. Grade: >98%. CAS No. 185413-30-3. Molecular formula: C96H123N19O22. Mole weight: 1895.14.
AF 12198 acetate
AF 12198 acetate is a potent, selective human type I IL-1 receptor antagonist. Synonyms: N-Acetyl-L-phenylalanyl-L-α-glutamyl-L-tryptophyl-L-threonyl-L-prolylglycyl-L-tryptophyl-L-tyrosyl-L-glutaminyl-(2S)-2-azetidinecarbonyl-L-tyrosyl-L-alanyl-L-leucyl-L-prolyl-L-leucinamide acetate; Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-Aze-Tyr-Ala-Leu-Pro-Leu-NH2.CH3CO2H; (N-(N-acetyl-L-phenylalanyl-L-alpha-glutamyl-L-tryptophyl-L-threonyl-L-prolyl-glycyl-L-tryptophyl-L-tyrosyl-L-glutaminyl)-(2S)-azetidine-2-carbonyl)-L-tyrosyl-L-alanyl-L-leucyl-L-prolyl-L-leucinamide acetate. Grade: ≥95%. Molecular formula: C98H127N19O24. Mole weight: 1955.17.
Calpain Inhibitor I
MG-101, also known as Calpain Inhibitor I and ALLN, is a calpain inhibitor (IC50 = 0.09 μM) that activates p53-dependent apoptosis in tumor cell lines. Activities of MG-101 includes: (1) reduce colon injury caused by dinitrobenzene sulphonic acid, (2) overcome acquired resistance to TRAIL, (3) protect against atractyloside-induced toxicity. (4). reduce colon injury caused by dinitrobenzene sulphonic acid. Synonyms: (S)-N-Acetyl-L-leucyl-N-(1-formylpentyl)-L-leucinamide; ALLN; ALLnL; CI-1 (peptide); Calp I; Calpain inhibitor I; MG 101; (S)-N-Acetyl-L-leucinyl-L-leucinyl-L-norleucinal; MG-101. Grade: 98 %. CAS No. 110044-82-1. Molecular formula: C20H37N3O4. Mole weight: 383.52.
Calpain Inhibitor II
Calpain inhibitor II is a cell-permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM). It inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Calpain inhibitor II can block nitric oxide production by interfering with transcription of the inducible nitric oxide synthase gene, which is a weak inhibitor of proteasome. It has been used to demonstrate the involvement of ubiquitin-proteasome protein degradation in various biological systems. Uses: Cysteine proteinase inhibitors. Synonyms: L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-; L-Leucinamide, N-acetyl-L-leucyl-N-[1-formyl-3-(methylthio)propyl]-, (S)-; N-Acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-L-leucinamide; ALLM; Calp II; CI 2; SUAM 312; N-acetylleucyl-leucyl-methioninal; Ac-Leu-Leu-Met-al; N-acetyl-L-leucyl-L-leucyl-L-methioninal. Grade: ≥98%. CAS No. 110115-07-6. Molecular formula: C19H35N3O4S. Mole weight: 401.57.
COG 133 acetate
COG 133 acetate is a fragment of ApoE that exhibits anti-inflammatory and neuroprotective effects and could also be an antagonist at α7 nicotinic acetylcholine receptors. Synonyms: Ac-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu-Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-NH2.CH3CO2H; N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-L-leucinamide acetic acid; L-Leucinamide, N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-, acetate (1:1). Grade: ≥95%. CAS No. 2763583-75-9. Molecular formula: C99H185N37O21. Mole weight: 2229.76.
COG 133 TFA
COG133 is a peptide fragment of ApoE that corresponds to residues 133-149 of the ApoE LDL receptor-binding domain and an antagonist of α7 nicotinic acetylcholine receptors (nAChRs; IC50 = 720 nM). It suppresses TNF-α and nitric oxide (NO) release in BV-2 microglia when used at concentrations ranging from 10 to 50 μM. Synonyms: L-Leucinamide, N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-, 2,2,2-trifluoroacetate (1:1); Ac-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu-Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-NH2.TFA; N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-L-leucinamide trifluoroacetic acid. Grade: 98%. CAS No. 2828432-37-5. Molecular formula: C99H182F3N37O21. Mole weight: 2283.78.
KLD12
KLD12, a hydrogel obtained from the self-assembled peptide, regulates in vitro chondrogenesis of bovine bone marrow stromal cells. Synonyms: Ac-Lys-Leu-Asp-Leu-Lys-Leu-Asp-Leu-Lys-Leu-Asp-Leu-NH2; N-acetyl-L-lysyl-L-leucyl-L-alpha-aspartyl-L-leucyl-L-lysyl-L-leucyl-L-alpha-aspartyl-L-leucyl-L-lysyl-L-leucyl-L-alpha-aspartyl-L-leucinamide; L-Leucinamide, N2-acetyl-L-lysyl-L-leucyl-L-α-aspartyl-L-leucyl-L-lysyl-L-leucyl-L-α-aspartyl-L-leucyl-L-lysyl-L-leucyl-L-α-aspartyl-. Grade: ≥95% by HPLC. CAS No. 800379-47-9. Molecular formula: C68H122N16O19. Mole weight: 1467.79.
Leupeptin
Leupeptin, a naturally occurring protease inhibitor, has potential applications in cosmetics due to its anti-inflammatory properties and ability to inhibit various proteases. It can be used in skincare products to help reduce inflammation and provide soothing effects to the skin. Additionally, Leupeptin's ability to inhibit proteases could contribute to the prevention of skin degradation and promote skin health by preserving the structural integrity of proteins in the skin matrix. Therefore, Leupeptin's applications in cosmetics may include anti-inflammatory and skin-protective effects, making it a valuable ingredient for products aimed at reducing skin irritation and promoting a healthy skin environment. It is a reversible, competitive inhibitor that targets serine and cysteine proteases, including trypsin, plasmin, calpain, papain, and cathepsins B, H, and L. Synonyms: Ac-Leu-Leu-Arg-CHO; Acetyl Tripeptide; L-Leucinamide, N-acetyl-L-leucyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-, (S)-; N-Acetyl-L-leucyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-formylbutyl]-L-leucinamide; Acetyl-L-leucyl-L-leucyl-L-argininal; N-Acetyl-L-leucyl-L-leucyl-L-argininal; Ac-Leu-Leu-Arg-al; Ac-LLR-al. Grade: ≥95%. CAS No. 55123-66-5. Molecular formula: C20H38N6O4. Mole weight: 426.55.
Leupeptin hemisulfate
Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases. It can be used in skincare products to help reduce inflammation and provide soothing effects to the skin. Synonyms: Ac-Leu-Leu-Arg-CHO.1/2H2SO4; Acetyl Tripeptide; L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-formylbutyl]-, sulfate (2:1); L-Leucinamide, N-acetyl-L-leucyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-, (S)-, sulfate (2:1); Leupeptin sulfate (2:1); N-Acetyl-L-leucyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-formylbutyl]-L-leucinamide hemisulfate; Acetyl-L-leucyl-L-leucyl-L-argininal hemisulfate; N-Acetyl-L-leucyl-L-leucyl-L-argininal hemisulfate; Ac-Leu-Leu-Arg-al.1/2H2SO4; Ac-LLR-al.1/2H2SO4. Grade: 95%. CAS No. 103476-89-7. Molecular formula: C20H38N6O4.1/2H2SO4. Mole weight: 475.59.
N-Acetyl-D-leucinol
N-Acetyl-D-leucinol. Synonyms: Acetamide, N-[(1R)-1-(hydroxymethyl)-3-methylbutyl]-; (R)-N-(1-hydroxy-4-methylpentan-2-yl)acetamide. Grade: >95% by HPLC. CAS No. 2015198-19-1. Molecular formula: C8H17NO2. Mole weight: 159.23.
N-Acetyl-L-leucinol
N-Acetyl-L-leucinol. Synonyms: Acetamide, N-[1-(hydroxymethyl)-3-methylbutyl]-, (S)-; Ac-L-Leu-ol; (S)-N-(1-hydroxy-4-methylpentan-2-yl)acetamide. Grade: >95% by HPLC. CAS No. 35593-66-9. Molecular formula: C8H17NO2. Mole weight: 159.23.
When administered peripherally to normal adult mice, the pentamer P21 significantly enhanced cognition, increased proliferation and neuronal differentiation of adult hippocampal progenitors and promoted the expression of synaptic vesicle proteins, synaptophysin and synapsin I. P21 induced enhancement of neurogenesis and maturation of newly born neurons in the granular cell layer and subgranular zone of the dentate gyrus. Synonyms: Ac-Asp-Gly-Gly-Leu-adamantane-Gly-NH2; N-Acetyl-L-α-aspartylglycylglycyl-N-[(1s,3S,5R,7S)-3-(aminocarbonyl)tricyclo[3.3.1.13,7]dec-1-yl]-L-leucinamide. Grade: ≥95%. Molecular formula: C27H42N6O8. Mole weight: 578.66.
PG 97-269
PG 97-269, a selective high affinity VPAC1 receptor antagonist, has negligible affinity for PACAP type I receptors, with Kis of 15±5 and 2±1 nM for the rat and human VPAC1 receptors, respectively. It can be used to evaluate the physiological role of VIP in rats and human tissues. Synonyms: Acetyl-(D-Phe2,Lys15,Arg16,Leu27)-VIP (1-7)-GRF (8-27); Ac-His-D-Phe-Asp-Ala-Val-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Lys-Arg-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-NH2; L-Leucinamide, N-acetyl-L-histidyl-D-phenylalanyl-L-α-aspartyl-L-alanyl-L-valyl-L-phenylalanyl-L-threonyl-L-asparaginyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucyl-L-lysyl-L-arginyl-L-leucyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-isoleucyl-. Grade: ≥95%. CAS No. 202463-00-1. Molecular formula: C150H246N44O38. Mole weight: 3273.83.
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