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Synonyms: Ac-D-Leu-OH; (R)-Ac-2-amino-4-methylpentanoic acid. Grades: ≥ 99% (Assay by titration). CAS No. 19764-30-8. Molecular formula: C8H15NO3. Mole weight: 173.20.
Acetyl-D-leucine 99+%
Acetyl-D-leucine 99+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g, 100g. US Biological Life Sciences.
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Acetyl-DL-leucine
Acetyl-DL-leucine. Group: Biochemicals. Alternative Names: Ac-DL-Leu-OH; (RS)-Ac-2-amino-4-methyl-pentanoic acid. Grades: Highly Purified. CAS No. 99-15-0. Pack Sizes: 50g, 100g, 250g, 500g, 1kg. US Biological Life Sciences.
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Acetyl-DL-leucine 99+%
Acetyl-DL-leucine 99+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 25g, 100g, 250g, 1Kg. US Biological Life Sciences.
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Acetylleucine
Acetylleucine (N-Acetyl-DL-leucine), orally active compound, can be used for the research of acute vestibular vertigo, cerebellar ataxia and nystagmus [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N-Acetyl-DL-leucine. CAS No. 99-15-0. Pack Sizes: 10 mM * 1 mL; 5 g; 10 g. Product ID: HY-B1442.
Acetyl-L-leucine methyl ester 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g, 100g. US Biological Life Sciences.
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Indole-3-acetyl-l-leucine
Indole-3-acetyl-l-leucine. Group: Biochemicals. Alternative Names: N-(3indolylacetyl)-L-leucine. Grades: Highly Purified. CAS No. 36838-63-8. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C16H20N2O3. US Biological Life Sciences.
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leucine N-acetyltransferase
Propanoyl-CoA can act as a donor, but more slowly. L-Arginine, L-valine, L-phenylalanine and peptides containing L-leucine can act as acceptors. Group: Enzymes. Synonyms: leucineacetyltransferase. Enzyme Commission Number: EC 2.3.1.66. CAS No. 75496-56-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2246; leucine N-acetyltransferase; EC 2.3.1.66; 75496-56-9; leucineacetyltransferase. Cat No: EXWM-2246.
Levacetylleucine
Levacetylleucine, an orally bioavailable and brain-penetrant endogenous metabolite, is an acetylated derivative of amino acid leucine. Levacetylleucine is the active form of N-acetyl-leucine (NAL). Levacetylleucine attenuates neuronal death and neuroinflammation in the cortical tissue of mice. Levacetylleucine also potentially improves ameliorates lysosomal and metabolic dysfunction. Levacetylleucine improves compensation of postural symptoms after unilateral chemical labyrinthectomy (UL) in rats. Levacetylleucine is promising for research of neurological manifestations of Niemann-Pick disease type C, traumatic brain injury and neurodegeneration prevention [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 1188-21-2. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-59291.
N-Acetyl-L-leucine. Group: Biochemicals. Alternative Names: Ac-Leu-OH. Grades: Highly Purified. CAS No. 1188-21-2. Pack Sizes: 100g, 250g, 500g, 1kg, 2kg. Molecular Formula: C8H15NO3. US Biological Life Sciences.
Worldwide
N-Acetyl-L-Leucine
N-acetyl-L-leucine is the N-acetyl derivative of L-leucine. It has a role as a metabolite. It is a N-acetyl-L-amino acid and a L-leucine derivative. It is a conjugate acid of a N-acetyl-L-leucinate. It is an enantiomer of a N-acetyl-D-leucine. CAS No. 1188-21-2. Product ID: PAP-0012. Molecular formula: C8H15NO3. Category: Amino acid. Product Keywords: Amino Acid Series; N-Acetyl-L-Leucine; PAP-0012; Amino acid; C8H15NO3; 1188-21-2. Color: White. EC Number: 214-706-3. Physical State: Crystalline Powder. Solubility: DMSO (Slightly), Ethanol (Slightly), Water (Slightly, Heated). Storage: Sealed in dry,Room Temperature. Applications: N-Acetyl-L-Leucine is an important fine organic chemical intermediate, widely used in medicine, pesticides, chemical industry and other fields. Boiling Point: 303.86°C (rough estimate). Melting Point: 187-190 °C(lit.). Density: 1.1599 (rough estimate). Product Description: N-Acetyl-L-Leucine is an important fine organic chemical intermediate, widely used in medicine, pesticides, chemical industry and other fields.
It is produced by the strain of Streptomyces ambofaciens. It has anti-tumor activity and is not suitable for clinical use due to excessive toxicity. Its N-acetyl (Duazomycin) also has anti-tumor effect. Uses: Antibiotics, antineoplastic. Synonyms: 6-Diazo-5-oxonorleucine; 6-diazo-5-oxo-L-norleucine; L-DON; (S)-2-Amino-6-diazo-5-oxocaproic acid; L-6-Diazo-5-oxonorleucine; DON; NSC 7365; L-DON; 2-Amino-6-diazo-5-oxohexanolic acid. Grades: ≥ 99% (Assay by titration). CAS No. 157-03-9. Molecular formula: C6H9N3O3. Mole weight: 171.15.
Acetylleucine is a drug mianly used to treat the vertigo.It has been listed. Uses: Acetylleucine is used to treat the vertigo. Synonyms: Acetylleucine;N-Acetyl-DL-leucine;DL-Leucine,N-acetyl-;Acetyl-DL-leucine;Tanganil;2-Acetamido-4-methylpentanoic acid. Grades: >98 %. CAS No. 99-15-0. Molecular formula: C8H15NO3. Mole weight: 173.21.
acetyl-CoA C-acetyltransferase
This enzyme participates in 10 metabolic pathways: fatty acid metabolism, synthesis and degradation of ketone bodies, valine, leucine and isoleucine degradation, lysine degradation, tryptophan metabolism, pyruvate metabolism, benzoate degradation via coa ligation, propanoate metabolism, butanoate metabolism, and two-component system-general. Group: Enzymes. Synonyms: acetoacetyl-CoA thiolase; β-acetoacetyl coenzyme A thiolase; 2-methylacetoacetyl-CoA thiolase [misleading]; 3-oxothiolase; acetyl coenzyme A thiolase; acetyl-CoA acetyltransferase; acetyl-CoA:N-acetyltransferase; thiolase II. Enzyme Commission Number: EC 2.3.1.9. CAS No. 9027-46-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2271; acetyl-CoA C-acetyltransferase; EC 2.3.1.9; 9027-46-7; acetoacetyl-CoA thiolase; β-acetoacetyl coenzyme A thiolase; 2-methylacetoacetyl-CoA thiolase [misleading]; 3-oxothiolase; acetyl coenzyme A thiolase; acetyl-CoA acetyltransferase; acetyl-CoA:N-acetyltransferase; thiolase II. Cat No: EXWM-2271.
Acetyl-Heme-Binding Protein 1 (1-21) (human)
Acetyl-Heme-Binding Protein 1 (1-21) (human), an acetylated peptide corresponding to the N-terminal fragment of human heme-binding protein, specifically promotes calcium mobilization and chemotaxis in dendritic cells and monocytes via the FPR-like receptor 2 (FPRL 2). In neutrophils, it inhibits FPR and FPRL1-mediated signaling. Synonyms: F2L; Ac-Met-Leu-Gly-Met-Ile-Lys-Asn-Ser-Leu-Phe-Gly-Ser-Val-Glu-Thr-Trp-Pro-Trp-Gln-Val-Leu-OH; N-acetyl-L-methionyl-L-leucyl-glycyl-L-methionyl-L-isoleucyl-L-lysyl-L-asparagyl-L-seryl-L-leucyl-L-phenylalanyl-glycyl-L-seryl-L-valyl-L-alpha-glutamyl-L-threonyl-L-tryptophyl-L-prolyl-L-tryptophyl-L-glutaminyl-L-valyl-L-leucine. Grades: ≥95%. CAS No. 946571-77-3. Molecular formula: C116H176N26O30S2. Mole weight: 2478.96.
Heterocyclic Organic Compound. Alternative Names: Gly-Gly-Phe-Leu-NH2, [des-Tyr1]-Leucine enkephalinamide acetate salt, 100929-57-5. CAS No. 100929-57-5. Molecular formula: C21H33N5O6. Mole weight: 451.52. Purity: 0.96. IUPACName: acetic acid;(2S)-2-[[(2S)-2-[[2-[(2-aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanamide. Canonical SMILES: CC (C)CC (C (=O)N)NC (=O)C (CC1=CC=CC=C1)NC (=O)CNC (=O)CN. CC (=O)O. Catalog: ACM100929575.
Myelin Basic Protein MBP
Myelin basic protein MBP is the second most abundant protein in the central nervous system myelin and is responsible for the adhesion of the cytosolic surfaces of multilayered compact myelin. Synonyms: Myelin Basic Protein (4-14); MBP(4-14) bovine; Myelin Basic Protein Fragment 4-14; L-Leucine, L-glutaminyl-L-Lysyl-L-arginyl-L-prolyl-L-seryl-L-glutaminyl-L-arginyl-L-seryl-L-lysyl-L-tyrosyl-; H-Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu-OH; Myelin basic protein (4-14), N-acetylated. Grades: ≥95%. CAS No. 126768-94-3. Molecular formula: C60H103N21O17. Mole weight: 1390.59.
The enzyme was originally characterized from bacteria that produce the tripeptides bialaphos and phosalacine, which inhibit plant and bacterial glutamine synthetases. It is a radical S-adenosyl-L-methionine (SAM) enzyme that contains a [4Fe-4S] center and a methylcob(III)alamin cofactor. According to the proposed mechanism, the reduced iron-sulfur center donates an electron to SAM, resulting in homolytic cleavage of the carbon-sulfur bond to form a 5'-deoxyadenosyl radical that abstracts the hydrogen atom from the P-H bond of the substrate, forming a phosphinate-centered radical. This radical reacts with methylcob(III)alamin to produce the methylated product and cob...hosphinothricin-L-alanyl-L-alanine or N-acetyl-demethylphosphinothricin-L-alanyl-L-leucine, the intermediates in the biosynthesis of bialaphos and phosalacine, respectively. This transformation produces the only example of a carbon-phosphorus-carbon linkage known to occur in nature. Group: Enzymes. Synonyms: phpK (gene name); bcpD (gene name); P-methylase. Enzyme Commission Number: EC 2.1.1.326. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1934; N-acetyldemethylphosphinothricin P-methyltransferase; EC 2.1.1.326; phpK (gene name); bcpD (gene name); P-methylase. Cat No: EXWM-1934.
NTRC 824
NTRC 824 is a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2 (IC50 = 38 nM), with >150-fold selectivity for NTS2 over NTS1. Synonyms: N-[2-[5-[[(4-Methylphenyl)sulfonyl]amino]-3-(2,2,2-trifluoroacetyl)-1H-indol-1-yl]acetyl]-L-leucine; NTRC-824; NTRC 824; NTRC824. Grades: ≥98% by HPLC. CAS No. 1623002-61-8. Molecular formula: C25H26F3N3O6S. Mole weight: 553.55.
(O-Acetyl-L-Ser)-Leuprolide
(O-Acetyl-L-Ser)-Leuprolide is an impurity of Leuprolide, which is a synthetic nonapeptide analog of gonadotropin-releasing hormone used as an antineoplastic agent, a gonadotropin-releasing hormone agonist, and an anti-estrogen. Synonyms: 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl(Ac)-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide; 1-9-Luteinizing hormone-releasing factor (swine), 4-(O-acetyl-L-serine)-6-D-leucine-9-(N-ethyl-L-prolinamide)-; Pyr-His-Trp-Ser(Ac)-Tyr-Leu-Leu-Arg-Pro-NHEt; Ser(Ac)-Leuprolide; L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-O-acetyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-; L-pyroglutamyl-L-histidyl-L-tryptophyl-O-acetyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-L-proline ethylamide; Leuprolide Acetate EP Impurity D; Leuprolide Impurity D. Grades: ≥95%. CAS No. 1926163-25-8. Molecular formula: C61H86N16O13. Mole weight: 1251.46.
opine dehydrogenase
In the forward direction, the enzyme from Arthrobacter sp. acts also on secondary amine dicarboxylates such as N-(1-carboxyethyl)methionine and N-(1-carboxyethyl)phenylalanine. Dehydrogenation forms an imine, which dissociates to the amino acid and pyruvate. In the reverse direction, the enzyme acts also on neutral amino acids as an amino donor. They include L-amino acids such as 2-aminopentanoic acid, 2-aminobutyric acid, 2-aminohexanoic acid, 3-chloroalanine, O-acetylserine, methionine, isoleucine, valine, phenylalanine, leucine and alanine. The amino acceptors include 2-oxoacids such as pyruvate, oxaloacetate, glyoxylate and 2-oxobutyrate. Group: Enzymes. Synonyms: (2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate dehydrogenase (NAD+, L-aminopentanoate-forming). Enzyme Commission Number: EC 1.5.1.28. CAS No. 108281-02-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1510; opine dehydrogenase; EC 1.5.1.28; 108281-02-3; (2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate dehydrogenase (NAD+, L-aminopentanoate-forming). Cat No: EXWM-1510.
OTSSP167 hydrochloride
OTSSP167 is a potent inhibitor of Maternal embryonic leucine zipper kinase (MELK) which regulates neural stem cell selfrenewal through control of the cell cycle. Synonyms: 4-[7-acetyl-8-[[4-[ (dimethylamino) methyl]cyclohexyl]amino]-1H-1, 5-naphthyridin-2-ylidene]-2, 6-dichlorocyclohexa-2, 5-dien-1-one hydrochloride; OTSSP167 (hydrochloride); UNII-65P731R507; 65P731R507; OTSSP167 HCl; OTS-167 monohydrochloride; HY-15512A; AKOS025117447. CAS No. 1431698-10-0. Molecular formula: C25H29Cl3N4O2. Mole weight: 523.9.
Verrucofortine
A diketopiperazine alkaloid derived from tryptophan and leucine. It is a fungal metabolite isolated from penicillium verrucosum. It exhibits no apparent toxicity in mice even at high doses in vivo. Synonyms: Fructigenine B; Verrucosine; Verrucozine; (-)-Verrucofortine; (3S-(3alpha,5aalpha,10balpha,11abeta))-6-Acetyl-10b-(1,1-dimethyl-2-propenyl)-6,10b,11,11a-tetrahydro-3-(2-methylpropyl)-2H-pyrazino(1',2':1,5)pyrrolo(2,3-b)indole-1,4-(3H,5aH)-dione; (3S,5aR,10bR,11aS)-6-acetyl-10b-(1,1-dimethyl-2-propen-1-yl)-6,10b,11,11a-tetrahydro-3-(2-methylpropyl)-2H-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione. Grades: >99% by HPLC. CAS No. 113706-21-1. Molecular formula: C24H31N3O3. Mole weight: 409.52.
Xaa-methyl-His dipeptidase
This enzyme catalyses the following chemical reaction: hydrolysis of anserine (beta-alanyl-Npi-methyl-L-histidine), carnosine, homocarnosine, glycyl-leucine and other dipeptides with broad specificity. Group: Enzymes. Synonyms: anserinase; aminoacyl-methylhistidine dipeptidase; acetylhistidine deacetylase; N-acetylhistidine deacetylase; α-N-acetyl-L-histidine aminohydrolase; X-methyl-His dipeptidase. Enzyme Commission Number: EC 3.4.13.5. CAS No. 9027-38-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4038; Xaa-methyl-His dipeptidase; EC 3.4.13.5; 9027-38-7; anserinase; aminoacyl-methylhistidine dipeptidase; acetylhistidine deacetylase; N-acetylhistidine deacetylase; α-N-acetyl-L-histidine aminohydrolase; X-methyl-His dipeptidase. Cat No: EXWM-4038.
Acetyl-Tau Peptide (273-284) amide
Tau (273-284) forms homooligomers and heterooligomers with Aβ (25-35). Synonyms: Ac-Gly-Lys-Val-Gln-Ile-Ile-Asn-Lys-Lys-Leu-Asp-Leu-NH2; L-Leucinamide, N-acetylglycyl-L-lysyl-L-valyl-L-glutaminyl-L-isoleucyl-L-isoleucyl-L-asparaginyl-L-lysyl-L-lysyl-L-leucyl-L-α-aspartyl-. Grades: ≥95%. CAS No. 1684399-52-7. Molecular formula: C64H116N18O17. Mole weight: 1409.74.
Ac-PAL-AMC
Ac-PAL-AMC is a fluorogenic substrate for the β1i/LMP2 subunit of the 20S immunoproteasome. It can be cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the activity of the β1i/LMP2 subunit of the 20S immunoproteasome. Synonyms: Acetyl-Pro-Ala-Leu-7-amino-4-Methylcoumarin; 1-acetyl-L-prolyl-L-alanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-leucinamide. Grades: ≥95%. CAS No. 1431362-79-6. Molecular formula: C26H34N4O6. Mole weight: 498.6.
AF 12198
It is a potent, selective human type I IL-1 receptor antagonist. Synonyms: N-Acetyl-L-phenylalanyl-L-α-glutamyl-L-tryptophyl-L-threonyl-L-prolylglycyl-L-tryptophyl-L-tyrosyl-L-glutaminyl-(2S)-2-azetidinecarbonyl-L-tyrosyl-L-alanyl-L-leucyl-L-prolyl-L-Leucinamide; Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-L-azetidine-2-carbonyl-Tyr-Ala-Leu-Pro-Leu-NH2. Grades: >98%. CAS No. 185413-30-3. Molecular formula: C96H123N19O22. Mole weight: 1895.14.
AF 12198 acetate
AF 12198 acetate is a potent, selective human type I IL-1 receptor antagonist. Synonyms: N-Acetyl-L-phenylalanyl-L-α-glutamyl-L-tryptophyl-L-threonyl-L-prolylglycyl-L-tryptophyl-L-tyrosyl-L-glutaminyl-(2S)-2-azetidinecarbonyl-L-tyrosyl-L-alanyl-L-leucyl-L-prolyl-L-leucinamide acetate; Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-Aze-Tyr-Ala-Leu-Pro-Leu-NH2.CH3CO2H; (N-(N-acetyl-L-phenylalanyl-L-alpha-glutamyl-L-tryptophyl-L-threonyl-L-prolyl-glycyl-L-tryptophyl-L-tyrosyl-L-glutaminyl)-(2S)-azetidine-2-carbonyl)-L-tyrosyl-L-alanyl-L-leucyl-L-prolyl-L-leucinamide acetate. Grades: ≥95%. Molecular formula: C98H127N19O24. Mole weight: 1955.17.
Calpain Inhibitor I
MG-101, also known as Calpain Inhibitor I and ALLN, is a calpain inhibitor (IC50 = 0.09 μM) that activates p53-dependent apoptosis in tumor cell lines. Activities of MG-101 includes: (1) reduce colon injury caused by dinitrobenzene sulphonic acid, (2) overcome acquired resistance to TRAIL, (3) protect against atractyloside-induced toxicity. (4). reduce colon injury caused by dinitrobenzene sulphonic acid. Synonyms: (S)-N-Acetyl-L-leucyl-N-(1-formylpentyl)-L-leucinamide; ALLN; ALLnL; CI-1 (peptide); Calp I; Calpain inhibitor I; MG 101; (S)-N-Acetyl-L-leucinyl-L-leucinyl-L-norleucinal; MG-101. Grades: 98 %. CAS No. 110044-82-1. Molecular formula: C20H37N3O4. Mole weight: 383.52.
Calpain Inhibitor II
Calpain inhibitor II is a cell-permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM). It inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Calpain inhibitor II can block nitric oxide production by interfering with transcription of the inducible nitric oxide synthase gene, which is a weak inhibitor of proteasome. It has been used to demonstrate the involvement of ubiquitin-proteasome protein degradation in various biological systems. Uses: Cysteine proteinase inhibitors. Synonyms: L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-; L-Leucinamide, N-acetyl-L-leucyl-N-[1-formyl-3-(methylthio)propyl]-, (S)-; N-Acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-L-leucinamide; ALLM; Calp II; CI 2; SUAM 312; N-acetylleucyl-leucyl-methioninal; Ac-Leu-Leu-Met-al; N-acetyl-L-leucyl-L-leucyl-L-methioninal. Grades: ≥98%. CAS No. 110115-07-6. Molecular formula: C19H35N3O4S. Mole weight: 401.57.
COG 133 acetate
COG 133 acetate is a fragment of ApoE that exhibits anti-inflammatory and neuroprotective effects and could also be an antagonist at α7 nicotinic acetylcholine receptors. Synonyms: Ac-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu-Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-NH2.CH3CO2H; N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-L-leucinamide acetic acid; L-Leucinamide, N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-, acetate (1:1). Grades: ≥95%. CAS No. 2763583-75-9. Molecular formula: C99H185N37O21. Mole weight: 2229.76.
COG 133 TFA
COG133 is a peptide fragment of ApoE that corresponds to residues 133-149 of the ApoE LDL receptor-binding domain and an antagonist of α7 nicotinic acetylcholine receptors (nAChRs; IC50 = 720 nM). It suppresses TNF-α and nitric oxide (NO) release in BV-2 microglia when used at concentrations ranging from 10 to 50 μM. Synonyms: L-Leucinamide, N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-, 2,2,2-trifluoroacetate (1:1); Ac-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu-Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-NH2.TFA; N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-L-leucinamide trifluoroacetic acid. Grades: 98%. CAS No. 2828432-37-5. Molecular formula: C99H182F3N37O21. Mole weight: 2283.78.
KLD12
KLD12, a hydrogel obtained from the self-assembled peptide, regulates in vitro chondrogenesis of bovine bone marrow stromal cells. Synonyms: Ac-Lys-Leu-Asp-Leu-Lys-Leu-Asp-Leu-Lys-Leu-Asp-Leu-NH2; N-acetyl-L-lysyl-L-leucyl-L-alpha-aspartyl-L-leucyl-L-lysyl-L-leucyl-L-alpha-aspartyl-L-leucyl-L-lysyl-L-leucyl-L-alpha-aspartyl-L-leucinamide; L-Leucinamide, N2-acetyl-L-lysyl-L-leucyl-L-α-aspartyl-L-leucyl-L-lysyl-L-leucyl-L-α-aspartyl-L-leucyl-L-lysyl-L-leucyl-L-α-aspartyl-. Grades: ≥95% by HPLC. CAS No. 800379-47-9. Molecular formula: C68H122N16O19. Mole weight: 1467.79.
Leupeptin
Leupeptin reversibly inhibits serine proteinases (trypsin (Ki=3.5 nM), plasmin (Ki= 3.4 nM), porcine kallikrein), and cysteine proteinases (papain, cathepsin B (Ki = 4.1 nM), endoproteinase Lys-C). Leupeptin has been shown to inhibit activation-induced programmed cell death. Synonyms: 2-(2-acetamido-4-methylvaleramido)-n-(1-formyl-4-guanidinobutyl)-4-methylval; 2-(2-acetamido-4-methylvaleramido)-n-(1-formyl-4-guanidinobutyl)-4-valeramid; leupeptinac-ll; l-leucinamide,n-acetyl-l-leucyl-n-(4-((aminoiminomethyl)amino)-1-formylbutyl; Leupeptin; Leupeptin Ac-LL; N-Acetyl-L-leucyl-L-leucyl-L-argininal; NK-381; NK 381; NK381. Grades: >98%. CAS No. 24365-47-7. Molecular formula: C20H38N6O4. Mole weight: 426.55.
PG 97-269, a selective high affinity VPAC1 receptor antagonist, has negligible affinity for PACAP type I receptors, with Kis of 15±5 and 2±1 nM for the rat and human VPAC1 receptors, respectively. It can be used to evaluate the physiological role of VIP in rats and human tissues. Synonyms: Acetyl-(D-Phe2,Lys15,Arg16,Leu27)-VIP (1-7)-GRF (8-27); Ac-His-D-Phe-Asp-Ala-Val-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Lys-Arg-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-NH2; L-Leucinamide, N-acetyl-L-histidyl-D-phenylalanyl-L-α-aspartyl-L-alanyl-L-valyl-L-phenylalanyl-L-threonyl-L-asparaginyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucyl-L-lysyl-L-arginyl-L-leucyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-isoleucyl-. Grades: ≥95%. CAS No. 202463-00-1. Molecular formula: C150H246N44O38. Mole weight: 3273.83.
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