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| Product | Description | |
|---|---|---|
| leukocyte elastase | Differs from pancreatic elastase in specificity on synthetic substrates and in inhibitor sensitivity. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.11. Group: Enzymes. Synonyms: lysosomal elastase; neutrophil elastase; polymorphonuclear leukocyte elastase; elastase; elaszym; serine elastase; lysosomal elastase; granulocyte elastase. Enzyme Commission Number: EC 3.4.21.37. CAS No. 9004-6-2. ELA2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4131; leukocyte elastase; EC 3.4.21.37; 9004-06-2; lysosomal elastase; neutrophil elastase; polymorphonuclear leukocyte elastase; elastase; elaszym; serine elastase; lysosomal elastase; granulocyte elastase. Cat No: EXWM-4131. |  |
| Elastase, Human leukocytes | Elastase, Human leukocytes is a serine protease present in the nitrogen-loving granules of neutrophils. Elastase, Human leukocytes potential substrates include almost all components of the extracellular matrix, as well as a variety of proteins such as coagulation factors, complement, immunoglobulins and cytokines. It has a strong proteolytic function and participates in the pathogenesis of inflammatory tissue damage [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9004-6-2. Pack Sizes: 1 U. Product ID: HY-P2751. |  |
| 1,1,2-Ethanetricarboxylic Acid 1,1,2-Triethyl Ester | 1,1,2-Ethanetricarboxylic Acid 1,1,2-Triethyl Ester is a useful synthetic intermediate. It can be used to prepare Isobutylsuccinic Acid (I780660) which was used to synthesize succinimide derivatives as inhibitors of human leukocyte elastase, cathepsin G and proteinase 3. Group: Biochemicals. Grades: Highly Purified. CAS No. 7459-46-3. Pack Sizes: 5g, 10g. Molecular Formula: C11H18O6. US Biological Life Sciences. |  Worldwide |
| 2-Hydroxy-4-methylpyridine-d3 | 2-Hydroxy-4-methylpyridine-d3 is the isotope labelled analog of 2-Hydroxy-4-methylpyridine (H949890); an intermediate used to prepare oxobenzopyrancarboxyl ate derivatives as inhibitors of serine proteases and human leukocyte elastase. It is also used in the synthesis of (indanylamino) (pyridinyloxy) pyrazines and analogs as corticotropin releasing factor type-1 receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 1185316-03-3. Pack Sizes: 5mg, 10mg. Molecular Formula: C6H4D3NO, Molecular Weight: 112.14. US Biological Life Sciences. | Worldwide |
| 2-Hydroxy-4-methylpyridine-d6 | 2-Hydroxy-4-methylpyridine-d6 is the isotope labelled analog of 2-Hydroxy-4-methylpyridine (H949890); an intermediate used to prepare oxobenzopyrancarboxyl ate derivatives as inhibitors of serine proteases and human leukocyte elastase. It is also used in the synthesis of (indanylamino) (pyridinyloxy) pyrazines and analogs as corticotropin releasing factor type-1 receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 916979-13-0. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C6HD6NO, Molecular Weight: 115.16. US Biological Life Sciences. | Worldwide |
| Cathepsin G Inhibitor I | Cathepsin G inhibitor I is a potent and selective inhibitor of cathepsin G with IC50 of 53 nM. It weakly inhibits chymotrypsin and poorly inhibits thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase. Synonyms: Cathepsin G Inhibitor I; 429676-93-7; Cathepsin G Inhibitor; CHEMBL164694; [2-[3-[(1-benzoylpiperidin-4-yl)-methylcarbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2-oxoethyl]phosphonic acid; SCHEMBL1613660; DTXSID80431393; BDBM50139754; HY-103351; CS-0027703; A918760; (2-{3-[(1-Benzoyl-piperidin-4-yl)-methyl-carbamoyl]-naphthalen-2-yl}-1-naphthalen-1-yl-2-oxo-ethyl)-phosphonic acid; [2-[3-[(1-benzoylpiperidin-4-yl)-methylcarbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2 oxoethyl]phosphonic acid. Grade: ≥95%. CAS No. 429676-93-7. Molecular formula: C36H33N2O6P. Mole weight: 620.6. |  |
| Chymostatin | Chymostatin is a bioactive peptide that acts as a protease inhibitor with selectivity for chymotryptase-like serine proteases. It potently inhibits chymotrypsin and chymase, but it cannot block the activity of cathepsins, papain, and leukocyte elastase effectively. It doesn't have effect on trypsin, thrombin, plasmin, pepsin, and kallikrein. Uses: Serine proteinase inhibitors. Synonyms: [(S)-1-Carboxy-2-phenylethyl]-carbamoyl-a-[2-amidohexahydro-4(S)-pyrimidyl]-(S)-glycyl-[A= Leu B=Val C=Ile]-phenylalaninal (Mixture). Grade: ≥95% (a mixture of A, B, C). CAS No. 9076-44-2. Molecular formula: CxHyN7O6. Mole weight: 607.7. | |
| DMP 777 | DMP 777 is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: L-694458. CAS No. 157341-41-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-75957. | |
| DMP 777 | DMP 777(L-694458) is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor. Synonyms: L-694458; L 694458; L694458; DMP-777; DMP777. Grade: >98%. CAS No. 157341-41-8. Molecular formula: C31H40N4O6. Mole weight: 564.67. | |
| Elasnin | Elasnin is isolated from certain strains of Streptomyces. Elasnin is a reversible inhibitor of elastase with IC50 values of 1.3 and 30 μg/ml for human granulocyte and pancreatic enzymes, respectively. It inhibits human leukocyte elastase, porcine pancreatic elastase, and chymotrypsin with Ki values of 93, 69 and 224 μM, respectively. Synonyms: 3,5-dibutyl-2-hydroxy-6-(6-oxoundecan-5-yl)-4H-pyran-4-one; 3,?5-Dibutyl-6-(1-butyl-2-oxoheptyl)?-4-hydroxy-2H-pyran-2-one. Grade: ≥98%. CAS No. 68112-21-0. Molecular formula: C24H40O4. Mole weight: 392.57. | |
| Elasnin (3,5-Dibutyl-4-hydroxy-6-(6-oxoundecan-5-yl)-2H-pyran-2-one) | Inhibitor of human leukocyte elastase (IC50=1.3ug/ml), different other elastases and chymotrypsin (IC50=82ug/ml). Group: Biochemicals. Grades: Highly Purified. CAS No. 68112-21-0. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Elastase | Elastase. Synonyms: EC 3.4.21.36;EC 3.4.21.37;ELASTASE, LEUKOCYTE;ELASTASE, NEUTROPHIL, HUMAN;ELASTASE, HUMAN NEUTROPHIL;ELASTASE, HUMAN NEUTROPHILS;Elastase, pancreatic from porcine pancreas, 30 units/mg;Elastase froM porcine pancreas Min. 200 U/Mg lyophil. salt-free. CAS No. 39445-21-1. Pack Sizes: 1 g. Product ID: CDF4-0039. Category: Enzyme Preparations. Product Keywords: Food Ingredients; Enzyme Preparations; Elastase; CDF4-0039; 39445-21-1; 254-453-6; 39445-21-1. Purity: 0.99. Color: White. EC Number: 254-453-6. Physical State: Lyophilized Powder. Solubility: H2O: soluble. Storage: -20°C. |  |
| Elastase Inhibitor V (2-(2-Bromophenyl)-5-chloro-3,1-benzoxazin-4-one) | A benzoxazinone compound that acts as a potent inhibitor of human leukocyte elastase (IC50 = 29.5nM), likely by covalently modifying active site serine. Shown to inhibit elastase secretion (IC50 = 80.8nM), but not O2 - generation, in fLMP-stimulated primary human neutrophil cultures. Reported to reduce neutrophil infiltration in lung after hemorrhagic shock in rats in vivo (1mg/kg, i.v.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Elastase Substrate V, Fluorogenic - CAS 72252-90-5 | Elastase Substrate V, Fluorogenic, CAS 72252-90-5, is a sensitive fluorogenic substrate for the quantitative determination of human leukocyte and porcine pancreatic elastase (Km = 140 μM). Group: Fluorescence/luminescence spectroscopy. |  |
| Elastatinal | Elastatinal is a potent and irreversible inhibitor of pancreatic elastase. It is a much stronger inhibitor of pancreatic elastase than the leukocyte-derived enzyme. It can also inhibit elastase-like protease collagenolytic protease from C. maenas digestive glands. Synonyms: (2S)-2-[(4S)-2-amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxyethyl]-L-glutamamide. Grade: ≥ 95 %. CAS No. 51798-45-9. Molecular formula: C21H36N8O7. Mole weight: 512.56. | |
| MeOSuc-AAPV-AMC | MeOSuc-AAPV-AMC is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase (Km: 362 ?M, Ex=380 nm, Em=460 nm)[1]. Uses: Scientific research. Group: Peptides. CAS No. 72252-90-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-136865. | |
| MeoSuc-Ala-Ala-Pro-Val-AMC | MeOSuc-AAPV-AMC is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase. The methoxy succinyl (MeO-Suc) peptide AAPV is hydrolyzed by these elastases but not by cathepsin G. The addition of 7-amino-4-methylcoumarin (AMC) generates a peptide of low fluorescence (excitation: 355-380 nm; emission 440-460 nm) that demonstrates a linear increase in fluorescence intensity in the presence of elastase. Synonyms: MeOSuc-AAPV-AMC; I 1270; Methoxy Succinyl-Ala-Ala-Pro-Val-AMC; N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-valinamide. Grade: ≥95% by HPLC. CAS No. 72252-90-5. Molecular formula: C31H41N5O9. Mole weight: 627.7. | |
| MeOSuc-Ala-Ala-Pro-Val-Chloromethylketone | MeOSuc-Ala-Ala-Pro-Val-Chloromethylketone is an irreversible inhibitor of human leukocyte and neutrophil elastase with a Ki = 10 μM. Uses: Serine proteinase inhibitors. Synonyms: Msaapvck; Meosuc-aapv-cmk; methoxysuccinyl-alanyl-alanyl-prolyl-valine chloromethyl ketone; N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone. Grade: 95%. CAS No. 65144-34-5. Molecular formula: C22H35ClN4O7. Mole weight: 502.99. | |
| MeOSuc-Ala-Ala-Pro-Val-pNA | MeOSuc-Ala-Ala-Pro-Val-pNA is a sensitive chromogenic substrate for human leukocyte and porcine pancreatic elastase [1]. Uses: Scientific research. Group: Peptides. CAS No. 70967-90-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P2685. | |
| Methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide - CAS 70967-90-7 | Soluble, specific substrate for human leukocyte elastase. Group: Fluorescence/luminescence spectroscopy. | |
| Native Human Cathepsin G | Cathepsin G is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSG gene. The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, but it is most closely related to other immune serine proteases, such as neutrophil elastase and the granzymes. Cathepsin G may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. It also localizes to Neutrophil extracellular traps (NETs), via its high affinity for DNA, an unusual property for serine proteases. Transcript variants utilizing alternative polyadenylation signals exist for this gene. Group: Enzymes. Synonyms: CTSG; cathepsin G; CG; CATG; EC 3.4.21.20; chymotrypsin-like proteinase; neutral proteinase. Enzyme Commission Number: EC 3.4.21.20. CAS No. 56645-49-9. Purity: > 96% (SDS-PAGE). CTSG. Activity: > 5 U/mL. Appearance: Clear, colorless solution. Storage: 2-8°C. Form: Liquid. Source: Human Neutrophils. Species: Human. CTSG; cathepsin G; CG; CATG; EC 3.4.21.20; chymotrypsin-like proteinase; neutral proteinase. Cat No: NATE-0173. | |
| Native Human Elastase | Neutrophil elastase is a serine proteinase in the same family as chymotrypsin and has broad substrate specificity. Secreted by neutrophils and macrophages during inflammation, it destroys bacteria and host tissue. It also localizes to Neutrophil extracellular traps (NETs), via its high affinity for DNA, an unusual property for serine proteases. Leuk ocyte elastase is a 29 kda serine endoprotease of the proteinase s1 family. it exists as a single 238 amino acid-peptide chain with four disulfide bonds. it contains two or thee n-linked glycans of variable composition which account for its three major isoforms. Applications: Elastase from creative enzymes has been used to digest fibro...mal models. Group: Enzymes. Synonyms: ELANE; elastase; EC 3.4.21.37; leukocyte elastase; ELA2; elastase 2; neutrophil elaszym; serine elastase; lysosomal elastase; neutrophil elastase; polymorphonuclear leukocyte elastase; elaszym; granulocyte elastase. Enzyme Commission Number: EC 3.4.21.37. CAS No. 9004-6-2. ELA2. Mole weight: 29 kDa. Activity: > 50 units/mg protein (Bradford). Storage: -20°C. Form: Lyophilized from 0.05 M sodium acetate (pH 5.5) and 0.6 M NaCl. Source: Human leuk ocytes. Species: Human. ELANE; elastase; EC 3.4.21.37; leukocyte elastase; ELA2; elastase 2; neutrophil elaszym; serine elastase; lysosomal elastase; neutrophil elastase; polymorphonuclear leukocyte ela | |
| Succinyl-Ala-Ala-Pro-Phe-p-nitroanilide - CAS 70967-97-4 | Sensitive chromogenic substrate for human leukocyte cathepsin G that is not reactive with elastase. Group: Fluorescence/luminescence spectroscopy. | |
| Z-L-tyrosine 4-nitrophenyl ester | A substrate for human plasma and urinary kallikreins and for human leukocyte elastase. Synonyms: Z-L-Tyr-Onp; (S)-4-Nitrobenzyl 2-(((Benzyloxy)Carbonyl)Amino)-3-(4-Hydroxyphenyl)Propanoate; 4-Nitrophenyl N-[(Benzyloxy)Carbonyl]-L-Tyrosinate. Grade: ≥ 97%. CAS No. 3556-56-7. Molecular formula: C23H20N2O7. Mole weight: 436.40. | |
| Z-L-valine 4-nitrophenyl ester | A substrate for human leukocyte elastase. Synonyms: Z-L-Val-Onp; 4-Nitrophenyl N-((Benzyloxy)Carbonyl)-L-Valinate; (S)-4-NITROPHENYL 2-(((BENZYLOXY)CARBONYL)AMINO)-3-METHYLBUTANOATE. Grade: ≥ 99% (HPLC). CAS No. 10512-93-3. Molecular formula: C19H20N2O6. Mole weight: 372.38. | |
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