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| Product | Description | |
|---|---|---|
| E3 ligase Ligand-Linker Conjugates 30 | E3 ligase Ligand-Linker Conjugates 30 incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 30 can be used to design PROTAC MDM2 degrade. Synonyms: 4- ( (2- (2- (2- (2-aminoethoxy) ethoxy) ethoxy) ethyl) amino) -2- (2, 6-dioxopiperidin-3-yl) isoindoline-1, 3-dione; Pomalidomide-PEG3-C2-NH2; SCHEMBL19451340; BCP33441; HY-128716; CS-0099510; Cereblon Ligand-Linker Conjugates 5; E3 ligase Ligand-Linker Conjugates 30. Grades: > 98%. CAS No. 2093416-31-8. Molecular formula: C21H28N4O7. Mole weight: 448.47. |  |
| 1, 1'-Bis(4-methoxyphenyl)-[4, 4'-bipyridine]-1, 1'-diium | Nitrogen MOFs LigandsOrganic-linker Blocks. Alternative Names: 1-(4-Methoxyphenyl)-4-[1-(4-methoxyphenyl)pyridin-1-ium-4-yl]pyridin-1-ium,dichloride. CAS No. 100906-93-2. Molecular formula: C24H22Cl2N2O2. Mole weight: 441.35. Appearance: Yellow-brown powder. Purity: 0.95. Catalog: ACM100906932-2. |  |
| 1,1'-Ferrocenediboronic acid | 1,1'-Ferrocenediboronic acid is a ligand bridge linker. Group: Iron compound. CAS No. 32841-83-1. Molecular formula: C10H12B2FeO4. Mole weight: 273.67. Catalog: ACM32841831. | |
| 1,3,5-Tris(4'-carboxy[1,1'-biphenyl]-4-yl)benzene | 1,3,5-Tris(4'-carboxy[1,1'-biphenyl]-4-yl)benzene is used as a linker molecule for the synthesis of high performance metal-organic framework (MOFs). Group: Carboxylic acid mof ligand-tricarboxylic acid mof ligand. Alternative Names: TCBPB. CAS No. 911818-75-2. Product ID: 4-[4-[3, 5-bis[4- (4-carboxyphenyl) phenyl]phenyl]phenyl]benzoic acid. Molecular formula: 666.72. Mole weight: C45H30O6. C1=CC (=CC=C1C2=CC=C (C=C2)C (=O)O)C3=CC (=CC (=C3)C4=CC=C (C=C4)C5=CC=C (C=C5)C (=O)O)C6=CC=C (C=C6)C7=CC=C (C=C7)C (=O)O. 1S/C45H30O6/c46-43 (47)37-19-13-31 (14-20-37)28-1-7-34 (8-2-28)40-25-41 (35-9-3-29 (4-10-35)32-15-21-38 (22-16-32)44 (48)49)27-42 (26-40)36-11-5-30 (6-12-36)33-17-23-39 (24-18-33)45 (50)51/h1-27H, (H, 46, 47) (H, 48, 49) (H, 50, 51). PEQRGMPXYDIZSX-UHFFFAOYSA-N. 97%. |  |
| 1-(4-Phenylboronic acid pinacol ester)-1,2,2-triphenylethene | Organic-linker BlocksBoric & Borate COFs Ligands. Alternative Names: 4,4,5,5-Tetramethyl-2-(4-(1,2,2-triphenylvinyl)phenyl)-1,3,2-dioxaborolane. CAS No. 1260865-91-5. Molecular formula: C32H31BO2. Mole weight: 458.398. Appearance: Yellow powder. Purity: 0.97. Catalog: ACM1260865915. | |
| 1-Piperazinehexanoic acid-thalidomide | 1-Piperazinehexanoic acid-thalidomide is a conjugate of E3 ligase ligand and linker that serve as a key intermediate for the synthesis of complete JMV7048 (HY-162704) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2819682-33-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-162737. |  |
| [2,2':6',2''-Terpyridin]-4'-ol | Nitrogen MOFs LigandsOrganic-linker BlocksHydroxyl COFs Ligands. Alternative Names: 4'-Hydroxy-2,2':6',2''-terpyridine. CAS No. 101003-65-0. Molecular formula: C15H11N3O. Mole weight: 249.26734. Appearance: Orange solid powder. Purity: 0.98. Catalog: ACM101003650. | |
| 4,4'-Stilbenedicarboxylic acid | 4,4'-Stilbenedicarboxylic acid (SDA) is a luminescent ligand that is useful as an organic linker due to the presence of two carboxylic groups, which form bridges between metallic centers. It has conjugated aromatic rings that facilitate the formation of a rigid linker. SDA can be used in the hydrothermal synthesis of three-dimensional (3D) metal-organic frameworks, which have potential usage in sensing, drug delivery, luminescence, and gas adsorption. It may also be used in energy storage applications such as supercapacitors and batteries. Group: Hydrogen storage materials monomers. Alternative Names: 4, 4'-(1, 2-Ethenediyl)bisbenzoicacid, 4, 4'-Dicarboxystilbene, Biphenylethene-4, 4·-dicarboxylicacid, H2BPEA, H2SDC. CAS No. 100-31-2. Product ID: 4-[(E)-2-(4-carboxyphenyl)ethenyl]benzoic acid. Molecular formula: 268.26. Mole weight: C10H6(CO2H)2. C1=CC (=CC=C1C=CC2=CC=C (C=C2)C (=O)O)C (=O)O. 1S/C16H12O4/c17-15 (18)13-7-3-11 (4-8-13)1-2-12-5-9-14 (10-6-12)16 (19)20/h1-10H, (H, 17, 18) (H, 19, 20)/b2-1+. SBBQDUFLZGOASY-OWOJBTEDSA-N. 98%. | |
| 4-Azidobutylamine | 4-Azidobutylamine is a PROTAC linker, which refers to the alkyl chain composition. 4-Azidobutylamine can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1]. 4-Azidobutylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 88192-20-5. Pack Sizes: 100 mg; 250 mg; 1 g. Product ID: HY-108374. | |
| 5-Cyano-1,3-benzenedicarboxylic acid | 5-Cyano-1,3-benzenedicarboxylic acid (CYDC) is an organic linker that can be used as a ligand in the formation of metal-organic frameworks (MOFs). CYDC is a carboxylate ligand that can be used in the development of new materials for applications in light-emitting diodes (LEDs) and chemical sensors. Group: Hydrogen storage materials metal organic frameworks (mofs). Alternative Names: 5-Cyanoisophthalicacid,H2CyIPT. CAS No. 23341-13-1. Product ID: 5-cyanobenzene-1,3-dicarboxylic acid. Molecular formula: 191.14. Mole weight: (C21H9)n. C1=C(C=C(C=C1C(=O)O)C(=O)O)C#N. 1S/C9H5NO4/c10-4-5-1-6 (8 (11)12)3-7 (2-5)9 (13)14/h1-3H, (H, 11, 12) (H, 13, 14). YKADUTAIRWMMFI-UHFFFAOYSA-N. ≥95%. | |
| A 410099.1 amide-PEG2-amine-Boc | A 410099.1 amide-PEG2-amine-Boc is a functionalized IAP ligand containing an IAP ligand and a PEG linker of 2 O(CH2)2 units with Boc protected terminal amine, can be used to bind to the target protein ligand. CAS No. 2415256-16-3. Molecular formula: C38H60N6O8. Mole weight: 728.92. | |
| A 410099.1 amide-PEG3-amine-Boc | A 410099.1 amide-PEG3-amine-Boc is a functionalized IAP ligand containing an IAP ligand and a PEG linker of 3 O(CH2)2 units with Boc protected terminal amine, can be used to bind to the target protein ligand. CAS No. 2415256-19-6. Molecular formula: C40H64N6O9. Mole weight: 772.97. | |
| ABM-14 | ABM-14 is a ligand for targeting androgen receptor (AR) for PROTAC. ABM-14 binds to a ligand for VHL via linker to form ARCC-4 (HY-130492) to degrade AR [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1973408-76-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131388. | |
| ACBI1 | ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis. Synonyms: ACBI 1; ACBI-1; (2S,4R)-N-(2-(2-(4-((4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)methyl)phenoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide. CAS No. 2375564-55-7. Molecular formula: C49H58FN9O7S. Mole weight: 936.12. | |
| AP1867-2-(carboxymethoxy) | AP1867-2-(carboxymethoxy), the AP1867 (a synthetic FKBP12F36V-directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules. It is a ligand and a binder that contributes to the enhancer-promoter structural interactions of DNA elements. Synonyms: PROTAC FKBP12-binding moiety 2; 2-(2-((R)-3-(3,4-Dimethoxyphenyl)-1-(((S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carbonyl)oxy)propyl)phenoxy)acetic acid; 2-Piperidinecarboxylic acid, 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-, (1R)-1-[2-(carboxymethoxy)phenyl]-3-(3,4-dimethoxyphenyl)propyl ester, (2S)-; Ortho-AP1867. Grades: ≥96%. CAS No. 2230613-03-1. Molecular formula: C38H47NO11. Mole weight: 693.78. | |
| ARV-771 | ARV-771 is a potent BET bromodomain PROTAC® Degrader based on von Hippel-Lindau (VHL) E3 ligase, consisting of a BRD4-binding moiety bound to a VHL ligand via a linker. Synonyms: ARV 771; ARV771; (2S,4R)-1-((S)-2-(tert-butyl)-15-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide; L-Prolinamide, N- [2- [3- [2- [ [2- [ (6S) -4- (4-chlorophenyl) -2, 3, 9-trimethyl-6H-thieno [3, 2-f] [1, 2, 4] triazolo [4, 3-a] [1, 4] diazepin-6-yl] acetyl] amino] ethoxy] propoxy] acetyl] -3-methyl-L-valyl-4-hydroxy-N- [ (1S) -1- [4- (4-methyl-5-thiazolyl) phenyl] ethyl] -, (4R)-; N- ({3-[2- ({[ (6S) -4- (4-Chlorophenyl) -2, 3, 9-trimethyl-6H-thieno[3, 2-f][1, 2, 4]triazolo[4, 3-a][1, 4]diazepin-6-yl]acetyl}amino) ethoxy]propoxy}acetyl) -3-methyl-L-valyl- (4R) -4-hydroxy-N-{ (1S) -1-[4- (4-methyl-1, 3-thiazol-5-yl) phenyl]ethyl}-L-prolinamide. Grades: ≥95%. CAS No. 1949837-12-0. Molecular formula: C49H60ClN9O7S2. Mole weight: 986.64. | |
| ATRA-hydroxyimino | ATRA-hydroxyimino (CRABP-II ligand 1), the Retinoic acid (ATRA)-based moiety, binds to cIAP1 ligand (Bestatin) via a linker to form SNIPER to degrade CRABP-II in IMR-32 cells. Synonyms: ATRA-hydroxyimino; CRABP-II ligand 1. CAS No. 135325-47-2. Molecular formula: C20H27NO3. Mole weight: 329.43. | |
| Azido-PEG8-alcohol | O-(2-Azidoethyl)heptaethylene glycol (CAS# 352439-36-2) is used in the synthesis of heterobifunctionalized oligo(ethylene glycol) linkers for use in drug delivery. Uses: Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. in the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. monodisperse azide-peg8-alcohol (n3-peg8-oh) is a click chemistry reagent with an azide(n3) and a terminal hydroxyl (oh) group. the azide group is reactive with alkyne, bcn, dbco via click chemistry to yield a stable triazole linkage. the hydroxyl (oh) group enables further derivatization or replacement with other functional groups. Synonyms: N3-PEG8-OH; Azide-PEG8-alcohol; 2- [2- [2- [2- [2- [2- [2- (2-azidoethoxy) ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethanol. Grades: >97%. CAS No. 352439-36-2. Molecular formula: C16H33N3O8. Mole weight: 395.45. | |
| Azido-Thalidomide | Azido-Thalidomide is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand thalidomide conjugated to an alkyl linker with terminal azide group. Synonyms: E3 ligase Ligand-Linker Conjugates 18; N-(4-azidobutyl)-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide. Grades: ≥98%. CAS No. 2098488-36-7. Molecular formula: C19H20N6O6. Mole weight: 428.405. | |
| BCN-endo-PEG4-NHS | BCN-endo-PEG4-NHS is an ADC Linker containing 4 PEG units. BCN-endo-PEG4-NHS contains the lyophilic bidentate macrocyclic ligand endo-BCN, which allows for further synthesis of macrocyclic complexes. In click chemistry, endo-BCN can react with molecules containing azide groups to form stable triazoles in the absence of catalysts. Uses: Scientific research. Group: Signaling pathways. CAS No. 1702356-19-1. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-W096079. | |
| Benzaldehyde, 4-(1,2,2-triphenylethenyl)- | Organic-linker BlocksAldehyde COFs Ligands. Alternative Names: 4-(1,2,2-Triphenylvinyl)benzaldehyde. CAS No. 1289218-74-1. Molecular formula: C27H20O. Mole weight: 360.447107315063. Appearance: Light yellow solid powder. Purity: 0.98. Catalog: ACM1289218741. | |
| Benzenamine, 4-(bromomethyl)-N,N-bis[4-(bromomethyl)phenyl]- | Organic-linker BlocksHalogen COFs Ligands. Alternative Names: 4-(Bromomethyl)-N,N-bis[4-(bromomethyl)phenyl]aniline. CAS No. 100693-36-5. Molecular formula: C21H18Br3N. Mole weight: 524.086323261261. Appearance: Gray-yellow powder. Purity: 0.98. Catalog: ACM100693365. | |
| Benzyl 2-Chloroethyl Ether | Benzyl 2-Chloroethyl Ether is used in the synthesis of phosphane ligands with novel linker units that are complexed with rhodium to be used as building blocks for dendrimer catalysts. Also used in the formation of 2,6-diphenylpyrazine molecule derivatives which display cytotoxic properties. Group: Biochemicals. Alternative Names: Benzyl 2-chloroethyl Ether; 1-(Benzyloxy)-2-chloroethane; 2-Benzyloxy-1-chloroethane; 2-Phenylmethyloxyethyl Chloride; Benzyl 2-Chloroethyl Ether; NSC 11269; α-(2-Chloroethoxy)toluene. Grades: Highly Purified. CAS No. 17229-17-3. Pack Sizes: 1g. US Biological Life Sciences. |  Worldwide |
| β-GalNAc-PEG4-Azide | Asialoglycoprotein receptor ligand with PEG4 linker and azide group for onward chemistry. Uses: β-galnac-peg4-azide is a functionalized asialoglycoprotein receptor (asgpr) ligand for lysosomal targeting chimera (lytac) research and development; incorporates a single asgpr ligand with a peg4 linker and azide group reactive handle ready for conjugation. it can be used as a building block for multivalent compounds to enhance asgpr binding. upon binding to asgpr, β-galnac conjugates are efficiently internalized via asgpr-mediated endocytosis. β-galnac conjugation can be employed as a strategy to effectively deliver cargo such as rna or cas9 complexes in a cell-specific manner to hepatocytes. can be used to generate lytacs, or labeled with dye for tissue imaging. Group: Galnac conjugates. Alternative Names: 2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl 2-(acetylamino)-2-deoxy-β-D-galactopyranoside. CAS No. 879004-92-9. Molecular formula: C16H30N4O9. Mole weight: 422.44. Purity: >95% (HPLC). Canonical SMILES: [N-]=[N+]=NCCOCCOCCOCCO[C@H]1[C@@H] ([C@H] ([C@H] ([C@H] (O1)CO)O)O)NC (C)=O. Catalog: ACM879004929. | |
| Bis(sulfosuccinimidyl) Suberate, Sodium Salt (BS3) | A water-soluble protein cross-linker for: cross-linking and targeting of mouse erythrocytes, receptor-ligand cross-linking, cross-linking of calveolin proteins, cross-linking of growth factors to proteinase inhibitor, and cross-linking of glass beads. Group: Biochemicals. Alternative Names: BS3. Grades: Highly Purified. CAS No. 127634-19-9. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| DT2216 | DT2216 is a potent and selective BCL-XL ( Bcl-2 family member) degrader based on PROTAC technology. DT2216 causes effective degradation of BCL-XL protein by recruiting Von Hippel-Lindau (VHL) E3 ubiquitin ligase. DT2216 inhibits various BCL-XL-dependent leukemia and cancer cells but considerably less toxic to platelets. DT2216 is composed of the Bcl-2 family protein inhibitor Navitoclax (HY-10087), a linker, and a VHL E3 ubiquitin ligase (Red: Navitoclax; Blue: VHL ligand; Black: linker) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2365172-42-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130604. | |
| E3 ligase Ligand 32 | E3 ligase Ligand 32 (First product in Example 52) is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 32 can be connected to the ligand for protein by a linker to form PROTACs and can be used for the synthesis of PROTAC SMARCA2/4-degrader-29 (HY-162743) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2300099-98-1. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-W382038. | |
| Ethane diamine cycloimine organic cage | Cage-MOFs are metal organic frameworks (MOFs) having porous organic ligands. The CC1 cage finds applications as organic linker for 'Cage-MOFs' synthesis. Group: Hydrogen storage materials metal organic frameworks (mofs). Alternative Names: CC1,Cage1. CAS No. 1245063-59-5. Molecular formula: 792.98. Mole weight: (HO)2C6H2-1,4-(CO2H)2. 1S / C48H48N12 / c1-2-50-26-38-15-41-18-42 (16-38) 30-54-8-10-58-34-46-20-44-22-48 (24-46) 36-60-12-11-59-35-47-21-43 (19-45 (23-47) 33-57-9-7-53-29-41) 31-55-5-3-51-27-39-13-37 (25-49-1) 14-40 (17-39) 28-52-4-6-56-32-44 / h13-36H, 1-12H2 / b49-25+, 50-26+, 51-27+, 52-28+, 53-29+, 54-30+, 55-31+, 56-32+, 57-33+, 58-34+, 59-35+, 60-36+. GUTZSUDNSFKJNV-WMKISWKQSA-N. | |
| Ethane diamine cycloimine organic cage | Cage-MOFs are metal organic frameworks (MOFs) having porous organic ligands. The CC1 cage finds applications as organic linker for 'Cage-MOFs' synthesis. Group: Nitrogenated organic linkers. Alternative Names: CC1,Cage1. CAS No. 1245063-59-5. Molecular formula: (HO)2C6H2-1,4-(CO2H)2. Mole weight: 792.98. Appearance: powder. Catalog: ACM1245063595. | |
| FC-11 | FC-11 is a PROTAC FAK degrader ( DC 90 : 1 nM). FC-11 contains CRBN ligand Pomalidomide (HY-10984), linker and FAK ligand PF562271 (HY-10459) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2271035-37-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139344. | |
| FHD-609 | FHD-609 is a PROTAC degrader and inhibitor of BRD9 ( Bromodomain-containing protein 9 ). FHD-609 targets to ncBAF , can be used for research of wide range of cancers that contain a mutation in a BAF complex subunit. FHD-609 in combination with Telomelysin or INO5401, may play a role in adrenocortical carcinoma (ACC) treatment. (Blue: BRD9 ligand-6 (HY-49393), Black: linker (HY-168309); Pink: (S)-Deoxy-thalidomide-Br (HY-168308) ) [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2676211-64-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153367. | |
| KT-253 | KT-253 is a p53 stabilizer and a PROTAC degrader for MDM2 ( DC 50 =0.4 nM). KT-253 inhibits the proliferation of cancer cell RS4;11 with an IC 50 of 0.3 nM, arrests the cell cycle at G2/M phase, and induces apoptosis. KT-253 exhibits antitumor efficacy in mouse models [1]. (Pink: ligand for target protein MDM2 ligand 4 (HY-170452); Black: linker (HY-W001478); Blue: ligand for E3 ligase cereblon (HY-163927)). Uses: Scientific research. Group: Signaling pathways. CAS No. 2713618-08-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-170451. | |
| Lenalidomide-I | Lenalidomide-I (Compound 72), an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570 (HY-112609) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2207541-30-6. Pack Sizes: 100 mg; 250 mg; 500 mg. Product ID: HY-131318. | |
| MS39 | MS39 (compound 6) is a PROTAC targeting EGFR. MS39 is composed of PROTAC target protein ligand N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-(piperazin-1-yl)propoxy)quinazolin-4-amine (HY-W109039) (red part), E3 ligase ligand (S,R,S)-AHPC (HY-125845) (blue part) and PROTAC Linker Undecanedioic acid (HY-W014125) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is (S,R,S)-AHPC-CO-C9-acid (HY-139345). MS39 reduces the expression of EGFR and downstream signaling in HCC-827 and H3255 cells. MS39 inhibits the proliferation of H3255 cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2675490-92-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-157581. | |
| MS41 | MS41 is a selective eleven-nineteen leukemia (ENL) PROTAC degrader, with DC 50 s of 3.50 nM (MV4;11), 2.84 nM (SEMK2), 3.03 nM (Jurkat), and 26.58 nM (KASUMI1), respectively. MS41 effectively inhibits the growth of ENL-dependent leukemia cells, induces G1 cell cycle arrest and increases apoptosis. MS41 reduces the chromatin occupancy of ENL-associated transcription elongation machinery, and suppresses oncogenic gene expression and leukemia progression. Red: ENL ligand (HY-169094). Black: linker (HY-W105744). Blue: VHL ligand (HY-112078) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2768610-97-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-169093. | |
| NX-2127 | NX-2127 (compound 28) is an orally active PROTAC deggrader, targeting to Brutons Tyrosine Kinase (Btk). NX-2127 inhibits proliferation of BTK C481S mutant TMD8 cells, more effectively than Ibrutinib (HY-10997). NX-2127 catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3) with of 25 nM and 54 nM, respectively. NX-2127 stimulates T cell activation and increases IL-2 production in primary human T Cells [1] [2]. NX-2127 is composed of PROTAC target protein ligand (red part) BTK ligand 10 (HY-168302), E3 ligase ligand (blue part) Thalidomide 5-fluoride (HY-W087383) and PROTAC Linker (black part) (S)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline (HY-168303). Among which, the conjugate of E3 ubiquitin ligase ligand + Linker compose of Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 (HY-168304). Uses: Scientific research. Group: Signaling pathways. CAS No. 2416131-46-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153220. | |
| NX-5948 | NX-5948 (BTK-IN-24) is an orally active chimeric targeting molecule (CTM) that induces specific BTK protein degradation by the cereblon E3 ligase (CRBN) complex without degradation of other cereblon neo-substrates. NX-5948 mediates potent anti-inflammatory activity via BTK degradation with resultant inhibition of B cell activation. NX-5948 exhibits potent tumor growth inhibition in TMD8 xenograft models that contain either wild-type BTK or BTKi-resistant mutations. NX-5948 is efficacious in a mouse collageninduced arthritis (CIA) model. NX-5948 can cross the blood brain barrier (BBB). NX-5948 is a PROTAC composed of the ligand for target protein, a linker, and a cereblon E3 ligase (CRBN) complex (Red: ligand for target protein; Blue: CRBN; Black: linker) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BTK-IN-24. CAS No. 2649400-34-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-153321. | |
| Pomalidomide 4'-alkylC4-acid | Pomalidomide 4'-alkylC4-acid (linker16) is a E3 Ligase Ligand-Linker Conjugate. Pomalidomide 4'-alkylC4-acid can be used for conjugation to a target protein ligand [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2225940-48-5. Pack Sizes: 50 mg; 100 mg; 250 mg. Product ID: HY-131886. | |
| Pomalidomide 4'-alkylC5-acid | Pomalidomide 4'-alkylC5-acid (Example 3) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC5-acid can be used in the synthesis of PROTAC [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2225940-49-6. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-130737. | |
| Pomalidomide 4'-PEG3-azide | Pomalidomide 4'-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker. Pomalidomide 4'-PEG3-azide can be used for the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3 is a highly efficient PARP1 degrader based on Rucaparib by using the PROTAC approach [1]. Pomalidomide 4'-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2271036-46-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130652. | |
| Pomalidomide-amino-PEG4-NH2 hydrochloride | Pomalidomide-amino-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2331259-45-9. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-138859A. | |
| Pomalidomide-C2-NH2 | Pomalidomide-C2-NH2 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 17 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1]. Synonyms: 4-((2-aminoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; SCHEMBL17884390; TQP0427; Cereblon Ligand-Linker Conjugates 15; HY-128846; Pomalidomide-C2-NH2; Pomalidomide-alkylC2-amine; E3 ligase Ligand 17; 4-[(2-Aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride. Grades: > 98%. CAS No. 1957235-66-3. Molecular formula: C15H16N4O4. Mole weight: 316.31. | |
| Pomalidomide-C2-NH2 hydrochloride | Pomalidomide-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cereblon Ligand-Linker Conjugates 15 hydrochloride. CAS No. 2305369-00-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-128846A. | |
| Pomalidomide-C4-NH2 | Pomalidomide-C4-NH2 is a synthetic E3 ligase ligand-linker conjugate that incorporates Pomalidomide-based CRBN ligands and linkers used in PROTAC technology. Synonyms: 4-((4-aminobutyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-[(4-Aminobutyl)amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione; 4-[(4-Aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; 1H-Isoindole-1,3(2H)-dione, 4-[(4-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-; Thalidomide-NH-C4-NH2. Grades: ≥95%. CAS No. 1957236-34-8. Molecular formula: C17H20N4O4. Mole weight: 344.37. | |
| Pomalidomide-PEG2-azide | Pomalidomide-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology [1]. Pomalidomide-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2267306-14-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-137537. | |
| Pomalidomide-PEG3-azide | Pomalidomide-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology [1]. Pomalidomide-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2267306-15-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-137538. | |
| Pomalidomide-PEG3-C2-NH2 hydrochloride | Pomalidomide-PEG3-C2-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate containing a cereblon ligand based on Pomalidomide and a PEG linker of 3 O(CH2)2 units with terminal amine, as a part of a variety of functionalized PROTAC molecules for binding to a target protein ligand. Synonyms: Cereblon Ligand-Linker Conjugates 5 hydrochloride; E3 ligase Ligand-Linker Conjugates 30 hydrochloride. CAS No. 2446474-09-3. Molecular formula: C21H29ClN4O7. Mole weight: 484.93. | |
| Pomalidomide-PEG3-C2-NH2 TFA | Pomalidomide-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 5 (TFA)) is a synthetic E3 ligase ligand-linker conjugate comprising a Pomalidomide (HY-10984)-based cereblon ligand and a 3-unit PEG linker. Pomalidomide-PEG3-C2-NH2 TFA can be used for the synthesis of PROTACs [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cereblon Ligand-Linker Conjugates 5 TFA; E3 ligase Ligand-Linker Conjugates 30 TFA. CAS No. 2414913-97-4. Pack Sizes: 50 mg; 100 mg; 500 mg; 1 g; 2 g. Product ID: HY-128716A. | |
| Pomalidomide-PEG4-azide | Pomalidomide-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology [1]. Pomalidomide-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2271036-47-4. Pack Sizes: 50 mg; 100 mg; 250 mg. Product ID: HY-141015. | |
| Pomalidomide-PEG4-C2-NH2 hydrochloride | Pomalidomide-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in the synthesis of PROTACs. Uses: Scientific research. Group: Signaling pathways. CAS No. 2357105-92-9. Pack Sizes: 50 mg; 100 mg; 500 mg. Product ID: HY-112599B. | |
| PRO-6E | PRO-6E is an oral active PROTAC based on Cereblon ligand, and induces the degradation of MET with maximum degradation of 81.9% at 1 μM in MKN-45 cells. PRO-6E inhibits tumor growth in vivo and in vitro. PRO-6E induces cell apoptosis and induces cell arrest (Sturcture Note:(Blue: Cereblon ligand (HY-103596), Black: linker?Pink: ALK/c-Met inhibitor Crizotinib (HY-50878)) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2353493-69-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160506. | |
| PROTAC AR Degrader-8 | PROTAC AR Degrader-8 (Compound NP18) is the PROTAC degrader for androgen receptor ( AR ), that degrades AR-FL with DC 50 of 0.018 μM and 0.14 μM in 22Rv1 cell and LNCaP cell, degrades AR-V7 with DC 50 of 0.026 μM in 22Rv1 cell. PROTAC AR Degrader-8 inhibits the proliferation of cancer cell 22Rv1 and LNCaP with IC 50 of 0.038 μM and 1.11 μM. PROTAC AR Degrader-8 arrests cell cycle at G2/M phase, induces apoptosis in 22Rv1 cell. PROTAC AR Degrader-8 exhibits anticancer efficacy in mouse and zebrafish model [1]. (Pink: ligand for target protein AR ligand-33 (HY-170330); Black: linker (HY-W007731); Blue: ligand for E3 ligase Cereblon (HY-14658)). Uses: Scientific research. Group: Signaling pathways. CAS No. 3044108-04-2. Pack Sizes: 1 mg. Product ID: HY-170329. | |
| PT-65 | PT-65 is a potent and selective GSK3 PROTAC degrader with the highest degradation capacity of GSK3α ( DC 50 = 28.3 nM) and GSK3β ( DC 50 = 34.2 nM) in SH-SY5Y cells. PT-65 can be used in Alzheimer's disease research [1].(Pink: GSK3 inhibitor (HY-15761); Black: linker; Blue: CRBN Ligand (HY-10984)). Uses: Scientific research. Group: Signaling pathways. CAS No. 2721998-87-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-153166. | |
| Quizartinib | Quizartinib (AC220) is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a K d of 1.6 nM. Quizartinib inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC 50 s of 4.2 and 1.1 nM, respectively. Quizartinib can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib induces apoptosis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AC220; AC708. CAS No. 950769-58-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13001. | |
| Quizartinib dihydrochloride | Quizartinib dihydrochloride (AC220 dihydrochloride) is the dihydrochloride salt form of Quizartinib (HY-13001). Quizartinib dihydrochloride is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a K d of 1.6 nM. Quizartinib dihydrochloride inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC 50 s of 4.2 and 1.1 nM, respectively. Quizartinib dihydrochloride can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib dihydrochloride induces apoptosis [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AC220 dihydrochloride. CAS No. 1132827-21-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14217. | |
| (S,R,S)-AHPC | (S,R,S)-AHPC (MDK7526) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC (MDK7526) can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells. Synonyms: MDK7526; VH032-NH2; VHL ligand 1. CAS No. 1448297-52-6. Molecular formula: C22H30N4O3S. Mole weight: 430.56. | |
| (S,R,S)-AHPC | (S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC 50 of 1.11 μM in Ba/F3 cells [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VH032-NH2; VHL ligand 1. CAS No. 1448297-52-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-125845. | |
| (S,R,S)-AHPC-C3-NH2 hydrochloride | (S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VH032-C3-NH2 hydrochloride. CAS No. 2940858-65-9. Pack Sizes: 50 mg; 100 mg. Product ID: HY-130711B. | |
| (S,R,S)-AHPC-C5-COOH | (S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized E3 ligase ligand-linker conjugate , contains the VH032 VHL-based ligand and a linker to form PROTAC s. VH-032 is a selective and potent inhibitor of VHL/HIF-1α interaction with a K d of 185 nM, has the potential for the study of anemia and ischemic diseases [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VH032-C5-COOH. CAS No. 2267282-19-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136055. | |
| TC-E3 5032 | TC-E3 5032 is a linker used in PROTAC technology that can be used in the synthesis of HDAC6 and anaplastic lymphoma kinase (ALK) degraders. Synonyms: E3 ligase Ligand 4; 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-fluoro-; Thalidomide 4-fluoride; Thalidomide fluoride; 4-Fluoro-thalidomide; Cereblon ligand 4;E3 ligase Ligand 4; 2-(2,6-Dioxo-3-piperidinyl)-4-fluoro-1H-isoindole-1,3(2H)-dione. Grades: ≥ 98%. CAS No. 835616-60-9. Molecular formula: C13H9FN2O4. Mole weight: 276.22. | |
| TD-165 | TD-165 is a PROTAC-based cereblon ( CRBN ) degrader. TD-165 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2305936-56-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130714. | |
| Thalidomide 4'-ether-alkylC2-amine hydrochloride | Thalidomide 4'-ether-alkylC2-amine hydrochloride is a synthetic E3 ligand-linker conjugate containing a cereblon ligand based on Thalidomide and a short C2 alkyl linker with terminal amine for covalent binding, as a part of a variety of functionalized PROTAC molecules for binding to a target protein ligand. Synonyms: Thalidomide - linker 6. Grades: ≥95% by HPLC. CAS No. 2341840-99-9. Molecular formula: C15H16ClN3O5. Mole weight: 353.76. | |
| Thalidomide-4-O-C4-NH2 hydrochloride | Thalidomide-4-O-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide (HY-14658) based cereblon ligand and a linker used in PROTAC technology. Uses: Scientific research. Group: Signaling pathways. CAS No. 2376990-29-1. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-130948B. | |
| Thalidomide-5-PEG3-NH2 hydrochloride | Thalidomide-5-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2761385-81-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-138786A. | |
| Thalidomide-O-amido-C6-NH2 (TFA) | Thalidomide-O-amido-C6-Amine trifluoroacetate is a PROTAC block consist of Thalidomide linked to alkyl with Amine functional group for conjugation reactions. Synonyms: Thalidomide-O-amido-C6-NH2 (TFA); Cereblon Ligand-Linker Conjugates 11 (TFA); E3 Ligase Ligand-Linker Conjugates 25 (TFA); Thalidomide-O-amido-C6-Amine Trifluoroacetate; N-(6-aminohexyl)-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide;2,2,2-trifluoroacetic acid. CAS No. 1950635-14-9. Molecular formula: C23H27F3N4O8. Mole weight: 544.48. | |
| Thalidomide-O-amido-C8-NH2 (TFA) | Thalidomide-O-amido-C8-NH2 (TFA) is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology. Synonyms: E3 Ligase Ligand-Linker Conjugates 17. CAS No. 1950635-16-1. Molecular formula: C25H31F3N4O8. Mole weight: 572.53. | |
| Thalidomide-O-amido-PEG2-C2-NH2 TFA | Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cereblon Ligand-Linker Conjugates 10 TFA; E3 Ligase Ligand-Linker Conjugates 24 TFA. CAS No. 1957235-75-4. Pack Sizes: 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-112617A. | |
| Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride | Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2245697-84-9. Pack Sizes: 25 mg; 100 mg. Product ID: HY-107440A. | |
| Thalidomide-O-amido-PEG3-C2-NH2 TFA | Thalidomide-O-amido-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cereblon Ligand-Linker Conjugates 3 TFA; E3 ligase Ligand-Linker Conjugates 14 TFA. CAS No. 1957236-21-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103611. | |
| Thalidomide-O-C4-NH2 hydrochloride | Thalidomide-O-C4-NH2 hydrochloride is a synthetic E3 ligand-linker conjugate containing a cereblon ligand based on Thalidomide and a C4 alkyl linker with terminal amine, as a part of a variety of functionalized PROTAC molecules for binding to a target protein ligand. Synonyms: Thalidomide-linker 9. Grades: ≥95% by HPLC. CAS No. 2376990-29-1. Molecular formula: C17H20ClN3O5. Mole weight: 381.81. | |
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