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Product | Description | |
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E3 ligase Ligand-Linker Conjugates 30 Quick inquiry Where to buy Suppliers range | E3 ligase Ligand-Linker Conjugates 30 incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 30 can be used to design PROTAC MDM2 degrade. Synonyms: 4- ( (2- (2- (2- (2-aminoethoxy) ethoxy) ethoxy) ethyl) amino) -2- (2, 6-dioxopiperidin-3-yl) isoindoline-1, 3-dione; Pomalidomide-PEG3-C2-NH2; SCHEMBL19451340; BCP33441; HY-128716; CS-0099510; Cereblon Ligand-Linker Conjugates 5; E3 ligase Ligand-Linker Conjugates 30. Grades: > 98%. CAS No. 2093416-31-8. Molecular formula: C21H28N4O7. Mole weight: 448.47. | |
1,1'-Ferrocenediboronic acid Quick inquiry Where to buy Suppliers range | 1,1'-Ferrocenediboronic acid. Uses: 1,1'-Ferrocenediboronic acid is a ligand bridge linker. Group: Iron Compound. CAS No. 32841-83-1. Product ID: ACM32841831. Molecular formula: C10H12B2FeO4. Mole weight: 273.67. | |
1,3,5-Tris(4'-carboxy[1,1'-biphenyl]-4-yl)benzene Quick inquiry Where to buy Suppliers range | 1,3,5-Tris(4'-carboxy[1,1'-biphenyl]-4-yl)benzene is used as a linker molecule for the synthesis of high performance metal-organic framework (MOFs). Group: Carboxylic MOFs Ligands. Alternative Names: TCBPB. Grades: 97%. CAS No. 911818-75-2. Product ID: ACM911818752-2. Molecular formula: C45H30O6. Mole weight: 666.72. IUPAC Name: 4-[4-[3, 5-bis[4- (4-carboxyphenyl) phenyl]phenyl]phenyl]benzoic acid. Appearance: Yellow solid. SMILES: C1=CC (=CC=C1C2=CC=C (C=C2)C (=O)O)C3=CC (=CC (=C3)C4=CC=C (C=C4)C5=CC=C (C=C5)C (=O)O)C6=CC=C (C=C6)C7=CC=C (C=C7)C (=O)O. | |
1,5-Dibromo-2,4-bis(bromomethyl)benzene Quick inquiry Where to buy Suppliers range | 1,5-Dibromo-2,4-bis(bromomethyl)benzene. Group: Halogen MOFs Ligands; Organic-linker Blocks. Alternative Names: 1,5-Bis(bromomethyl)-2,4-dibromobenzene. Grades: 98%. CAS No. 35510-03-3. Product ID: ACM35510033-1. Molecular formula: C8H6Br4. Mole weight: 421.75. IUPAC Name: 1,5-dibromo-2,4-bis(bromomethyl)benzene. SMILES: C1=C(C(=CC(=C1CBr)Br)Br)CBr. | |
A 410099.1 amide-PEG2-amine-Boc Quick inquiry Where to buy Suppliers range | A 410099.1 amide-PEG2-amine-Boc is a functionalized IAP ligand containing an IAP ligand and a PEG linker of 2 O(CH2)2 units with Boc protected terminal amine, can be used to bind to the target protein ligand. CAS No. 2415256-16-3. Molecular formula: C38H60N6O8. Mole weight: 728.92. | |
A 410099.1 amide-PEG3-amine-Boc Quick inquiry Where to buy Suppliers range | A 410099.1 amide-PEG3-amine-Boc is a functionalized IAP ligand containing an IAP ligand and a PEG linker of 3 O(CH2)2 units with Boc protected terminal amine, can be used to bind to the target protein ligand. CAS No. 2415256-19-6. Molecular formula: C40H64N6O9. Mole weight: 772.97. | |
ACBI1 Quick inquiry Where to buy Suppliers range | ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis. Synonyms: ACBI 1; ACBI-1; (2S,4R)-N-(2-(2-(4-((4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)methyl)phenoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide. CAS No. 2375564-55-7. Molecular formula: C49H58FN9O7S. Mole weight: 936.12. | |
AP1867-2-(carboxymethoxy) Quick inquiry Where to buy Suppliers range | AP1867-2-(carboxymethoxy), the AP1867 (a synthetic FKBP12F36V-directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules. It is a ligand and a binder that contributes to the enhancer-promoter structural interactions of DNA elements. Synonyms: PROTAC FKBP12-binding moiety 2; 2-(2-((R)-3-(3,4-Dimethoxyphenyl)-1-(((S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carbonyl)oxy)propyl)phenoxy)acetic acid; 2-Piperidinecarboxylic acid, 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-, (1R)-1-[2-(carboxymethoxy)phenyl]-3-(3,4-dimethoxyphenyl)propyl ester, (2S)-; Ortho-AP1867. Grades: ≥96%. CAS No. 2230613-03-1. Molecular formula: C38H47NO11. Mole weight: 693.78. | |
ARV-771 Quick inquiry Where to buy Suppliers range | ARV-771 is a potent BET bromodomain PROTACĀ® Degrader based on von Hippel-Lindau (VHL) E3 ligase, consisting of a BRD4-binding moiety bound to a VHL ligand via a linker. Synonyms: ARV 771; ARV771; (2S,4R)-1-((S)-2-(tert-butyl)-15-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide; L-Prolinamide, N- [2- [3- [2- [ [2- [ (6S) -4- (4-chlorophenyl) -2, 3, 9-trimethyl-6H-thieno [3, 2-f] [1, 2, 4] triazolo [4, 3-a] [1, 4] diazepin-6-yl] acetyl] amino] ethoxy] propoxy] acetyl] -3-methyl-L-valyl-4-hydroxy-N- [ (1S) -1- [4- (4-methyl-5-thiazolyl) phenyl] ethyl] -, (4R)-; N- ({3-[2- ({[ (6S) -4- (4-Chlorophenyl) -2, 3, 9-trimethyl-6H-thieno[3, 2-f][1, 2, 4]triazolo[4, 3-a][1, 4]diazepin-6-yl]acetyl}amino) ethoxy]propoxy}acetyl) -3-methyl-L-valyl- (4R) -4-hydroxy-N-{ (1S) -1-[4- (4-methyl-1, 3-thiazol-5-yl) phenyl]ethyl}-L-prolinamide. Grades: ≥95%. CAS No. 1949837-12-0. Molecular formula: C49H60ClN9O7S2. Mole weight: 986.64. | |
ATRA-hydroxyimino Quick inquiry Where to buy Suppliers range | ATRA-hydroxyimino (CRABP-II ligand 1), the Retinoic acid (ATRA)-based moiety, binds to cIAP1 ligand (Bestatin) via a linker to form SNIPER to degrade CRABP-II in IMR-32 cells. Synonyms: ATRA-hydroxyimino; CRABP-II ligand 1. CAS No. 135325-47-2. Molecular formula: C20H27NO3. Mole weight: 329.43. | |
Azido-PEG8-alcohol Quick inquiry Where to buy Suppliers range | O-(2-Azidoethyl)heptaethylene glycol (CAS# 352439-36-2) is used in the synthesis of heterobifunctionalized oligo(ethylene glycol) linkers for use in drug delivery. Uses: Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. in the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. monodisperse azide-peg8-alcohol (n3-peg8-oh) is a click chemistry reagent with an azide(n3) and a terminal hydroxyl (oh) group. the azide group is reactive with alkyne, bcn, dbco via click chemistry to yield a stable triazole linkage. the hydroxyl (oh) group enables further derivatization or replacement with other functional groups. Synonyms: N3-PEG8-OH; Azide-PEG8-alcohol; 2- [2- [2- [2- [2- [2- [2- (2-azidoethoxy) ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethanol. Grades: >97%. CAS No. 352439-36-2. Molecular formula: C16H33N3O8. Mole weight: 395.45. | |
Azido-Thalidomide Quick inquiry Where to buy Suppliers range | Azido-Thalidomide is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand thalidomide conjugated to an alkyl linker with terminal azide group. Synonyms: E3 ligase Ligand-Linker Conjugates 18; N-(4-azidobutyl)-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide. Grades: ≥98%. CAS No. 2098488-36-7. Molecular formula: C19H20N6O6. Mole weight: 428.405. | |
Benzyl 2-Chloroethyl Ether Quick inquiry Where to buy Suppliers range | Benzyl 2-Chloroethyl Ether is used in the synthesis of phosphane ligands with novel linker units that are complexed with rhodium to be used as building blocks for dendrimer catalysts. Also used in the formation of 2,6-diphenylpyrazine molecule derivatives which display cytotoxic properties. Group: Biochemicals. Alternative Names: Benzyl 2-chloroethyl Ether; 1-(Benzyloxy)-2-chloroethane; 2-Benzyloxy-1-chloroethane; 2-Phenylmethyloxyethyl Chloride; Benzyl 2-Chloroethyl Ether; NSC 11269; α-(2-Chloroethoxy)toluene. Grades: Highly Purified. CAS No. 17229-17-3. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
Bis(sulfosuccinimidyl) Suberate, Sodium Salt (BS3) Quick inquiry Where to buy Suppliers range | A water-soluble protein cross-linker for: cross-linking and targeting of mouse erythrocytes, receptor-ligand cross-linking, cross-linking of calveolin proteins, cross-linking of growth factors to proteinase inhibitor, and cross-linking of glass beads. Group: Biochemicals. Alternative Names: BS3. Grades: Highly Purified. CAS No. 127634-19-9. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
Maleimide-PEG-FITC Quick inquiry Where to buy Suppliers range | Maleimide-PEG-FITC (MAL-PEG-FITC) is a heterofunctional linker, which has maleimide group on one end for conjugation of thiol-containing ligands, and fluorescent probe (green) on the other end for labeling. Group: Photoactive Polymers. Alternative Names: MAL-PEG-FITC. Product ID: ACMA00018054. | |
Maleimide-PEG-Rhodamine Quick inquiry Where to buy Suppliers range | Maleimide-PEG-Rhodamine (MAL-PEG-RhB) is a heterofunctional linker, which has maleimide group on one end for conjugation of thiol-containing ligands, and fluorescent probe (red) on the other end for labeling. Group: Photoactive Polymers. Alternative Names: MAL-PEG-RhB. Product ID: ACMA00018055. | |
Pomalidomide-C2-NH2 Quick inquiry Where to buy Suppliers range | Pomalidomide-C2-NH2 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 17 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1]. Synonyms: 4-((2-aminoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; SCHEMBL17884390; TQP0427; Cereblon Ligand-Linker Conjugates 15; HY-128846; Pomalidomide-C2-NH2; Pomalidomide-alkylC2-amine; E3 ligase Ligand 17; 4-[(2-Aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride. Grades: > 98%. CAS No. 1957235-66-3. Molecular formula: C15H16N4O4. Mole weight: 316.31. | |
Pomalidomide-C4-NH2 Quick inquiry Where to buy Suppliers range | Pomalidomide-C4-NH2 is a synthetic E3 ligase ligand-linker conjugate that incorporates Pomalidomide-based CRBN ligands and linkers used in PROTAC technology. Synonyms: 4-((4-aminobutyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-[(4-Aminobutyl)amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione; 4-[(4-Aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; 1H-Isoindole-1,3(2H)-dione, 4-[(4-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-; Thalidomide-NH-C4-NH2. Grades: ≥95%. CAS No. 1957236-34-8. Molecular formula: C17H20N4O4. Mole weight: 344.37. | |
Pomalidomide-PEG3-C2-NH2 hydrochloride Quick inquiry Where to buy Suppliers range | Pomalidomide-PEG3-C2-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate containing a cereblon ligand based on Pomalidomide and a PEG linker of 3 O(CH2)2 units with terminal amine, as a part of a variety of functionalized PROTAC molecules for binding to a target protein ligand. Synonyms: Cereblon Ligand-Linker Conjugates 5 hydrochloride; E3 ligase Ligand-Linker Conjugates 30 hydrochloride. CAS No. 2446474-09-3. Molecular formula: C21H29ClN4O7. Mole weight: 484.93. | |
(S,R,S)-AHPC Quick inquiry Where to buy Suppliers range | (S,R,S)-AHPC (MDK7526) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC (MDK7526) can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells. Synonyms: MDK7526; VH032-NH2; VHL ligand 1. CAS No. 1448297-52-6. Molecular formula: C22H30N4O3S. Mole weight: 430.56. | |
TC-E3 5032 Quick inquiry Where to buy Suppliers range | TC-E3 5032 is a linker used in PROTAC technology that can be used in the synthesis of HDAC6 and anaplastic lymphoma kinase (ALK) degraders. Synonyms: E3 ligase Ligand 4; 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-fluoro-; Thalidomide 4-fluoride; Thalidomide fluoride; 4-Fluoro-thalidomide; Cereblon ligand 4;E3 ligase Ligand 4; 2-(2,6-Dioxo-3-piperidinyl)-4-fluoro-1H-isoindole-1,3(2H)-dione. Grades: ≥ 98%. CAS No. 835616-60-9. Molecular formula: C13H9FN2O4. Mole weight: 276.22. | |
Thalidomide 4'-ether-alkylC2-amine hydrochloride Quick inquiry Where to buy Suppliers range | Thalidomide 4'-ether-alkylC2-amine hydrochloride is a synthetic E3 ligand-linker conjugate containing a cereblon ligand based on Thalidomide and a short C2 alkyl linker with terminal amine for covalent binding, as a part of a variety of functionalized PROTAC molecules for binding to a target protein ligand. Synonyms: Thalidomide - linker 6. Grades: ≥95% by HPLC. CAS No. 2341840-99-9. Molecular formula: C15H16ClN3O5. Mole weight: 353.76. | |
Thalidomide-O-amido-C6-NH2 (TFA) Quick inquiry Where to buy Suppliers range | Thalidomide-O-amido-C6-Amine trifluoroacetate is a PROTAC block consist of Thalidomide linked to alkyl with Amine functional group for conjugation reactions. Synonyms: Thalidomide-O-amido-C6-NH2 (TFA); Cereblon Ligand-Linker Conjugates 11 (TFA); E3 Ligase Ligand-Linker Conjugates 25 (TFA); Thalidomide-O-amido-C6-Amine Trifluoroacetate; N-(6-aminohexyl)-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide;2,2,2-trifluoroacetic acid. CAS No. 1950635-14-9. Molecular formula: C23H27F3N4O8. Mole weight: 544.48. | |
Thalidomide-O-amido-C8-NH2 (TFA) Quick inquiry Where to buy Suppliers range | Thalidomide-O-amido-C8-NH2 (TFA) is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology. Synonyms: E3 Ligase Ligand-Linker Conjugates 17. CAS No. 1950635-16-1. Molecular formula: C25H31F3N4O8. Mole weight: 572.53. | |
Thalidomide-O-C4-NH2 hydrochloride Quick inquiry Where to buy Suppliers range | Thalidomide-O-C4-NH2 hydrochloride is a synthetic E3 ligand-linker conjugate containing a cereblon ligand based on Thalidomide and a C4 alkyl linker with terminal amine, as a part of a variety of functionalized PROTAC molecules for binding to a target protein ligand. Synonyms: Thalidomide-linker 9. Grades: ≥95% by HPLC. CAS No. 2376990-29-1. Molecular formula: C17H20ClN3O5. Mole weight: 381.81. | |
Thalidomide, propargyl Quick inquiry Where to buy Suppliers range | Thalidomide, propargyl is a cereblon-recruiting ligand consisting of an E3 ubiquitin ligase thalidomide conjugated to an alkyne linker ready for a target protein ligand. It has been used in PROTAC technology for target protein degradation. Synonyms: 2-(2,6-Dioxo-3-piperidinyl)-4-(2-propyn-1-yloxy)-1H-isoindole-1,3(2H)-dione. Grades: ≥98%. CAS No. 2098487-39-7. Molecular formula: C16H12N2O5. Mole weight: 312.28. | |
Thiol-PEG-Rhodamine Quick inquiry Where to buy Suppliers range | Thiol-PEG-Rhodamine (RhB-PEG-SH) is a heterofunctional linker, which has thiol group on one end for conjugation of thiol-containing ligands, and fluorescent probe (red) on the other end for labeling. Group: Photoactive Polymers. Alternative Names: RhB-PEG-SH. Product ID: ACMA00018088. | |
Trimethyl [2,2':6',2''-terpyridine]-4,4',4''-tricarboxylate Quick inquiry Where to buy Suppliers range | Trimethyl [2,2':6',2''-terpyridine]-4,4',4''-tricarboxylate. Group: Nitrogen-Donor Ligands; Organic-linker Blocks. Alternative Names: 4,4',4''-Trimethoxycarbonyl-2,2':6',2''-terpyridine; Methyl 2,6-bis(4-methoxycarbonylpyridin-2-yl)pyridine-4-carboxylate. Grades: 97%. CAS No. 330680-46-1. Product ID: ACM330680461-2. Molecular formula: C21H17N3O6. Mole weight: 407.38. IUPAC Name: methyl 2,6-bis(4-methoxycarbonylpyridin-2-yl)pyridine-4-carboxylate. SMILES: COC (=O)C1=CC (=NC=C1)C2=CC (=CC (=N2)C3=NC=CC (=C3)C (=O)OC)C (=O)OC. | |
VH 032-linker 6 Quick inquiry Where to buy Suppliers range | VH 032-linker 6 is a von-Hippel-Lindau protein ligand (VHL) conjugated to a PEGylated crosslinker with terminal alkyne for PROTAC technology. It has been used as a degrader building block in PROTAC for targeted protein degradation. Synonyms: VH032-PEG3-acetylene; (2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-6,9,12-trioxa-3-azapentadec-14-yn-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide. Grades: ≥98%. CAS No. 2098799-80-3. Molecular formula: C31H42N4O7S. Mole weight: 614.75. |