Linker Conjugates Suppliers USA
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Product | Description | |
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E3 ligase Ligand-Linker Conjugates 30 Quick inquiry Where to buy Suppliers range | E3 ligase Ligand-Linker Conjugates 30 incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 30 can be used to design PROTAC MDM2 degrade. Synonyms: 4- ( (2- (2- (2- (2-aminoethoxy) ethoxy) ethoxy) ethyl) amino) -2- (2, 6-dioxopiperidin-3-yl) isoindoline-1, 3-dione; Pomalidomide-PEG3-C2-NH2; SCHEMBL19451340; BCP33441; HY-128716; CS-0099510; Cereblon Ligand-Linker Conjugates 5; E3 ligase Ligand-Linker Conjugates 30. Grades: > 98%. CAS No. 2093416-31-8. Molecular formula: C21H28N4O7. Mole weight: 448.47. | |
1-Amino-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic Acid Quick inquiry Where to buy Suppliers range | 1-Amino-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic Acid is used in targeted drug delivery as conjugate with carbon nanotubes. It is also used as linker for enzyme immobilization in optimization of bio-nano interface to enhance enzyme catalytic efficiency. Group: Biochemicals. Grades: Highly Purified. CAS No. 756526-04-2. Pack Sizes: 5mg, 10mg. Molecular Formula: C19H39NO10, Molecular Weight: 441.51. US Biological Life Sciences. | Worldwide |
2-(2-(2-Aminoethoxy)ethoxy)acetic acid Quick inquiry Where to buy Suppliers range | H2N-PEG2-CH2COOH belongs to a polyethylene glycol (PEG) linker covalently bound to E3 Ligase binding group (E3LB) and protein binding group (PB). H2N-PEG2-CH2COOH is a PEG derivative containing an amino group with a terminal carboxylic acid. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. PEG Linkers may be useful in the development of antibody drug conjugates and PROTACs. Synonyms: Amino-PEG2-CH2CO2H; Amino-PEG2-CH2COOH; Amino-PEG2-acetic acid. Grades: ≥95%. CAS No. 134978-97-5. Molecular formula: C6H13NO4. Mole weight: 163.17. | |
2,2-Bis(aminoethoxy)propane Quick inquiry Where to buy Suppliers range | 2,2-Bis(aminoethoxy)propane is an acid degradable amine monomer that can be used as a ketal containing cross-linker. It is a pH sensitive molecule that is used in the synthesis of polyurea and polyurethane. Uses: This homobifunctionalized amino ketal is primarily used in crosslinking cell lysate (linking polypeptides whose lysine side chains are nearest to each other). Primary amines commonly conjugate through acylation or alkylation of isothiocyanates; isocyanates; acyl azides; NHS esters; sulfonyl chlorides; aldehydes; carbonates; aryl halides; imidoesters; carbodiimides; anhydrides; and fluorophenyl esters. This diamine can also crosslink epoxies. 2,2-Bis(aminoethoxy)propane can be used in the preparation of biocompatible polymeric materials for the development of controlled drug delivery systems. Group: Aliphatic Functional Groups. Alternative Names: 2,2-Di(2-aminoethoxy)propane, Diamino ketal, 2, 2'-[ (1-Methylethylidene)bis (oxy)]bis (ethanamine). CAS No. 127090-71-5. Molecular Weight: 162.23. SMILES: CC(C)(OCCN)OCCN. Flash Point: ≥98%. | |
3'-Amino-Modifier Serinol CPG Quick inquiry Where to buy Suppliers range | 3'-Amino-Modifier Serinol CPG- a revolutionary solid-phase support in oligonucleotide synthesis known for its unique modified serinol linker harboring a primary amino group that offers itself as an excellent platform for conjugation or labeling, is an exceptional product. Prominently utilized in the development of innovative antisense oligonucleotide therapies for an array of pervasive ailments such as cancer and viral infections, it is a hallmark of cutting-edge scientific research. Synonyms: 3-Dimethoxytrityloxy-2- (3- (fluorenylmethoxycarbonylamino) propanamido) propyl-1-O-succinyl-long chain alkylamino-CPG. Mole weight: 224.15. | |
4-Arm PEG-Biotin Quick inquiry Where to buy Suppliers range | PEG-biotin can be used for PEGylation by binding to streptavidin and avidin with high affinity and specificity. Biotin is conjugated to a linear PEG through a stable amide linker. Group: Functional PEGs. Alternative Names: Multi-arm - four arm - Polyethylene Glycol Biotin. Product ID: ACMA00006091. Appearance: White/Off-white solid or viscous liquid depends on molecular weight. Storage: -20?,protected from light and moisture. | |
6-Azidohexanoic acid NHS ester Quick inquiry Where to buy Suppliers range | A noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Synonyms: N3-C5-NHS ester. Grades: ≥ 95% (HPLC). CAS No. 866363-70-4. Molecular formula: C10H14N4O4. Mole weight: 254.24. | |
8-Arm PEG-Biotin Quick inquiry Where to buy Suppliers range | PEG-biotin can be used for PEGylation by binding to streptavidin and avidin with high affinity and specificity. Biotin is conjugated to a linear PEG through a stable amide linker. Group: Functional PEGs. Product ID: ACMA00006127. Appearance: Crystalline solid or semi-solid. Storage: -20?, protected from light and moisture. | |
AEEA-AEEA Quick inquiry Where to buy Suppliers range | AEEA-AEEA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Synonyms: 17-amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecan-1-oic acid. CAS No. 1143516-05-5. Molecular formula: C12H24N2O7. Mole weight: 308.33. | |
Amino-PEG3-t-butyl acetate Quick inquiry Where to buy Suppliers range | NH2-PEG3-C1-Boc is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 5 can be used in the synthesis of a series of PROTACs. NH2-PEG3-C1-Boc is a PEG derivative containing an amino group with a t-butyl protected carboxyl group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions. PEG Linkers may be useful in the development of antibody drug conjugates, PROTACs and drug delivery methods. Synonyms: NH2-PEG3-C1-Boc; PROTAC Linker 5; Amino-PEG3-CH2CO2-t-butyl ester; H2N-PEG3-CH2COOtBu; Acetic acid, 2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester. Grades: >95%. CAS No. 189808-70-6. Molecular formula: C12H25NO5. Mole weight: 263.33. | |
Azide-Doxorubicin Liposome (PEGylated) Quick inquiry Where to buy Suppliers range | This formulation is Doxorubicin Liposome (PEGylated) with the azide group, which can react with an dibenzocyclooctyne (DBCO) by click chemistry. The conjugation chemistry is based on the reaction of the azide reagent with an DBCO linker to form a stable triazole. DBCO moiety can be on the antibody and azide moiety can be on liposomes and vice versa. Group: Drug-loaded liposome. | |
Azide-Liposome Quick inquiry Where to buy Suppliers range | Azide-Liposome is Liposome with the azide group, which can react with an dibenzocyclooctyne (DBCO) by click chemistry. The conjugation chemistry is based on the reaction of the azide reagent with an DBCO linker to form a stable triazole. DBCO moiety can be on the antibody and azide moiety can be on liposomes and vice versa. Group: Immunoliposomes. | |
Azide-Liposome (PEGylated) Quick inquiry Where to buy Suppliers range | Azide-Liposome (PEGylated) is Liposome (PEGylated) with the azide group, which can react with an dibenzocyclooctyne (DBCO) by click chemistry. The conjugation chemistry is based on the reaction of the azide reagent with an DBCO linker to form a stable triazole. DBCO moiety can be on the antibody and azide moiety can be on liposomes and vice versa. Group: Immunoliposomes. | |
Azide-PEG-Amine Quick inquiry Where to buy Suppliers range | Azide-PEG-Amine is a linear bifunctional PEG linker with a reactive azide (N3) and it is used for PEGylation via a click chemistry reaction with alkyne or acetylene or DBCO. The amine group can be used in conjugation with acid, NHS ester and other amine-reactive functional groups. Group: Functional PEGs. Alternative Names: N3 -PEG-NH2. Product ID: ACMA00006166. Appearance: Crystalline solid or semi-solid. Storage: -20?, protected from light and moisture. | |
Azido-PEG10-amine Quick inquiry Where to buy Suppliers range | Azido-PEG10-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a non-cleavable 9 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Synonyms: N3-PEG10-CH2CH2NH2; 32-Azido-3,6,9,12,15,18,21,24,27,30-decaoxadotriacontan-1-amine; O-(2-Aminoethyl)-O-(2-azidoethyl)nonaethylene Glycol; N3-PEG10-NH2. Grades: >97%. CAS No. 912849-73-1. Molecular formula: C22H46N4O10. Mole weight: 526.62. | |
Azido-PEG2-NHS ester Quick inquiry Where to buy Suppliers range | Azido-PEG2-NHS ester is a non-cleavable 2-unit PEG linker that can be used to synthesize antibody-conjugated drugs (ADCs). Synonyms: Azido-PEG2-CH2CO2-NHS; N3-PEG2-C2-NHS ester; Propanoic acid, 3-[2-(2-azidoethoxy)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester; N3-PEG2-CH2CH2COONHS Ester; Azido-PEG2-NHS; N3-PEG2-SPA; 1-({3-[2-(2-Azidoethoxy)ethoxy]propanoyl}oxy)-2,5-pyrrolidinedione; 2,5-Pyrrolidinedione, 1-[3-[2-(2-azidoethoxy)ethoxy]-1-oxopropoxy]-; 2,5-Dioxo-1-pyrrolidinyl 3-[2-(2-azidoethoxy)ethoxy]propanoate; N-Succinimido 9-azido-4,7-dioxanonanoate. Grades: ≥98%. CAS No. 1312309-64-0. Molecular formula: C11H16N4O6. Mole weight: 300.27. | |
Azido-PEG8-amine Quick inquiry Where to buy Suppliers range | Azido-PEG8-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a non-cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Synonyms: O-(2-Aminoethyl)-O'-(2-azidoethyl)heptaethylene glycol; N3-PEG8-CH2CH2NH2; Azido-PEG8-NH2; N3-PEG8-NH2; 26-Azido-3,6,9,12,15,18,21,24-octaoxahexacosan-1-amine. Grades: ≥90%. CAS No. 857891-82-8. Molecular formula: C18H38N4O8. Mole weight: 438.52. | |
Azido-Thalidomide Quick inquiry Where to buy Suppliers range | Azido-Thalidomide is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand thalidomide conjugated to an alkyl linker with terminal azide group. Synonyms: E3 ligase Ligand-Linker Conjugates 18; N-(4-azidobutyl)-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide. Grades: ≥98%. CAS No. 2098488-36-7. Molecular formula: C19H20N6O6. Mole weight: 428.405. | |
beta-Gal-TEG-N3 Quick inquiry Where to buy Suppliers range | beta-Gal-TEG-N3 is a biomedical product that plays a critical role in the field of drug delivery and diagnostics. It is commonly used as a linker molecule for the conjugation of beta-galactosidase enzymes to various drugs and imaging agents. This enables targeted delivery and localization of therapeutic and diagnostic substances for the treatment and detection of specific diseases, including cancers and genetic disorders. Molecular formula: C12H23N3O8. Mole weight: 337.33. | |
beta-Glc-TEG-N3 Quick inquiry Where to buy Suppliers range | beta-Glc-TEG-N3, a compound widely employed in biomedical research, operates as a chemical linker, facilitating the conjugation of target-specific molecules to diverse pharmaceuticals. This extraordinary versatility empowers the augmentation of drug delivery efficiency, fortifying therapeutic effectiveness in conditions like cancer and inflammatory ailments. Molecular formula: C12H23N3O8. Mole weight: 337.33. | |
Biotin-PEG-Biotin Quick inquiry Where to buy Suppliers range | Biotin-PEG-biotin can be used for crosslinking PEGylation by binding to streptavidin and avidin with high affinity and specificity. Biotin is conjugated to a linear PEG through a stable amide linker. Group: Functional PEGs. Alternative Names: Bifunctional biotin PEG linker. Product ID: ACMA00006169. Appearance: Crystalline solid or semi-solid. Storage: -20?, protected from light and moisture. | |
Biotin-PEG-SH Quick inquiry Where to buy Suppliers range | Biotin-PEG-SH is used for PEGylation by binding to streptavidin or avidin with high affinity and specificity. Biotin is conjugated to a linear PEG through a stable amide linker. Group: Functional PEGs. Alternative Names: Biotin PEGylated Thiol. Product ID: ACMA00006175. Appearance: Crystalline solid or semi-solid. Storage: -20?, protected from light and moisture. | |
Boc-Gly-Gly-Phe-Gly-OH Quick inquiry Where to buy Suppliers range | Boc-Gly-Gly-Phe-Gly-OH is a self-assembly of N- and C-protected tetrapeptide. It is also a protease-cleavable linker for antibody-drug conjugates (ADCs). Synonyms: N-tert-butoxycarbonyl-glycyl-glycyl-L-phenylalanyl-glycine; N-(tert-butoxycarbonyl)-glycylglycyl-L-phenylalanylglycine; (S)-12-Benzyl-2,2-dimethyl-4,7,10,13-tetraoxo-3-oxa-5,8,11,14-tetraazahexadecan-16-oic acid. Grades: >95%. CAS No. 187794-49-6. Molecular formula: C20H28N4O7. Mole weight: 436.46. | |
Boc-Gly-Gly-Phe-Gly-OH TFA Quick inquiry Where to buy Suppliers range | Boc-Gly-Gly-Phe-Gly-OH TFA, a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC). Synonyms: Boc-Gly-Gly-Phe-Gly-OH trifluoroacetic acid; N-tert-butoxycarbonyl-glycyl-glycyl-L-phenylalanyl-glycine trifluoroacetic acid. Grades: >98%. Molecular formula: C22H29F3N4O9. Mole weight: 550.48. | |
Boc-Val-Cit-OH Quick inquiry Where to buy Suppliers range | Boc-Val-Cit-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Synonyms: (2S) -5- (carbamoylamino) -2- [ [ (2S) -3-methyl-2- [ (2-methylpropan-2-yl) oxycarbonylamino] butanoyl] amino] pentanoic acid. Grades: ≥95.0%. CAS No. 870487-08-4. Molecular formula: C16H30N4O6. Mole weight: 374.43. | |
CdSe/ZnS quantum dots, amine functionalized, fluorescence: λem 520nm Quick inquiry Where to buy Suppliers range | Amine-functionalized CdS/ZnS or CdSe/ZnS quantum dots (QDs) find applications in bioimaging and biosensing. The three main conjugation methods reported in the literature are conjugation using glutaraldehyde as a linker, conjugation by using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) Conjugation with carboxylic acid-containing molecules and direct conjugation with isothiocyanate bearing molecules. Uses: ·Bioimaging ·Biosensing. Group: Colloidal Quantum Dots. Flash Point: 99.9 %. | |
CdSe/ZnS quantum dots, amine functionalized, fluorescence: λem 540nm Quick inquiry Where to buy Suppliers range | Amine-functionalized CdS/ZnS or CdSe/ZnS quantum dots (QDs) find applications in bioimaging and biosensing. The three main conjugation methods reported in the literature are conjugation using glutaraldehyde as a linker, conjugation by using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) Conjugation with carboxylic acid-containing molecules and direct conjugation with isothiocyanate bearing molecules. Uses: ·Bioimaging ·Biosensing. Group: Colloidal Quantum Dots. Flash Point: 99.9 %. | |
CdSe/ZnS quantum dots, amine functionalized, fluorescence: λem 560nm Quick inquiry Where to buy Suppliers range | Amine-functionalized CdS/ZnS or CdSe/ZnS quantum dots (QDs) find applications in bioimaging and biosensing. The three main conjugation methods reported in the literature are conjugation using glutaraldehyde as a linker, conjugation by using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) Conjugation with carboxylic acid-containing molecules and direct conjugation with isothiocyanate bearing molecules. Uses: ·Bioimaging ·Biosensing. Group: Colloidal Quantum Dots. Flash Point: 99.9 %. | |
CdSe/ZnS quantum dots, amine functionalized, fluorescence: λem 580nm Quick inquiry Where to buy Suppliers range | Amine-functionalized CdS/ZnS or CdSe/ZnS quantum dots (QDs) find applications in bioimaging and biosensing. The three main conjugation methods reported in the literature are conjugation using glutaraldehyde as a linker, conjugation by using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) Conjugation with carboxylic acid-containing molecules and direct conjugation with isothiocyanate bearing molecules. Uses: ·Bioimaging ·Biosensing. Group: Colloidal Quantum Dots. Flash Point: 99.9 %. | |
CdSe/ZnS quantum dots, amine functionalized, fluorescence: λem 600nm Quick inquiry Where to buy Suppliers range | Amine-functionalized CdS/ZnS or CdSe/ZnS quantum dots (QDs) find applications in bioimaging and biosensing. The three main conjugation methods reported in the literature are conjugation using glutaraldehyde as a linker, conjugation by using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) Conjugation with carboxylic acid-containing molecules and direct conjugation with isothiocyanate bearing molecules. Uses: ·Bioimaging ·Biosensing. Group: Colloidal Quantum Dots. Flash Point: 99.9 %. | |
CdSe/ZnS quantum dots, amine functionalized, fluorescence: λem 620nm Quick inquiry Where to buy Suppliers range | Amine-functionalized CdS/ZnS or CdSe/ZnS quantum dots (QDs) find applications in bioimaging and biosensing. The three main conjugation methods reported in the literature are conjugation using glutaraldehyde as a linker, conjugation by using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) Conjugation with carboxylic acid-containing molecules and direct conjugation with isothiocyanate bearing molecules. Uses: ·Bioimaging ·Biosensing. Group: Colloidal Quantum Dots. Flash Point: 99.9 %. | |
CdSe/ZnS quantum dots, amine functionalized, fluorescence: λem 645nm Quick inquiry Where to buy Suppliers range | Amine-functionalized CdS/ZnS or CdSe/ZnS quantum dots (QDs) find applications in bioimaging and biosensing. The three main conjugation methods reported in the literature are conjugation using glutaraldehyde as a linker, conjugation by using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) Conjugation with carboxylic acid-containing molecules and direct conjugation with isothiocyanate bearing molecules. Uses: ·Bioimaging ·Biosensing. Group: Colloidal Quantum Dots. Flash Point: 99.9 %. | |
CdSe/ZnS quantum dots, PEG functionalized, fluorescence: λem 580nm Quick inquiry Where to buy Suppliers range | Amine-functionalized CdS/ZnS or CdSe/ZnS quantum dots (QDs) find applications in bioimaging and biosensing. The three main conjugation methods reported in the literature are conjugation using glutaraldehyde as a linker, conjugation by using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) Conjugation with carboxylic acid-containing molecules and direct conjugation with isothiocyanate bearing molecules. Uses: ·Bioimaging ·Biosensing. Group: Colloidal Quantum Dots. Flash Point: 99.9 %. | |
CdS/ZnS quantum dots, amine functionalized, fluorescence: λem 450nm Quick inquiry Where to buy Suppliers range | Amine-functionalized CdS/ZnS or CdSe/ZnS quantum dots (QDs) find applications in bioimaging and biosensing. The three main conjugation methods reported in the literature are conjugation using glutaraldehyde as a linker, conjugation by using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) Conjugation with carboxylic acid-containing molecules and direct conjugation with isothiocyanate bearing molecules. Uses: ·Bioimaging ·Biosensing. Group: Colloidal Quantum Dots. Flash Point: 99.9 %. | |
DBCO-acid Quick inquiry Where to buy Suppliers range | DBCO-acid is a cleavable ADC linker used in the synthesis of ADC linker DBCO-NHS ester (HY-115524 and HY-115545), and drug-linker conjugates DBCO-PEG-MMAE. Uses: White to light yellow powder to crystal. Synonyms: 11,12-Didehydro-gamma-oxodibenz[b,f]azocine-5(6H)-butanoic acid. Grades: > 98.0 %. CAS No. 1353016-70-2. Molecular formula: C19H15NO3. Mole weight: 305.33. | |
DBCO-Doxorubicin Liposome (PEGylated) Quick inquiry Where to buy Suppliers range | This formulation is Doxorubicin Liposome (PEGylated) with the dibenzocyclooctyne (DBCO) group, which can react with an azide by click chemistry. The conjugation chemistry is based on the reaction of the DBCO reagent with an azide linker to form a stable triazole. Azide moiety can be on the antibody and DBCO moiety can be on liposomes and vice versa. Group: Drug-loaded liposome. | |
DBCO-Liposome Quick inquiry Where to buy Suppliers range | DBCO-Liposome is Liposome with the dibenzocyclooctyne (DBCO) group, which can react with an azide by click chemistry. The conjugation chemistry is based on the reaction of the DBCO reagent with an azide linker to form a stable triazole. Azide moiety can be on the antibody and DBCO moiety can be on liposomes and vice versa. Group: Immunoliposomes. | |
DBCO-Liposome (PEGylated) Quick inquiry Where to buy Suppliers range | DBCO-Liposome (PEGylated) is Liposome (PEGylated) with the dibenzocyclooctyne (DBCO) group, which can react with an azide by click chemistry. The conjugation chemistry is based on the reaction of the DBCO reagent with an azide linker to form a stable triazole. Azide moiety can be on the antibody and DBCO moiety can be on liposomes and vice versa. Group: Immunoliposomes. | |
Deruxtecan Quick inquiry Where to buy Suppliers range | Deruxtecan analog is a drug-linker conjugate for antibody-drug conjugate (ADC). Deruxtecan, a topoisomerase I inhibitor, is an exatecan derivative (DX-8951 derivative) with a cleavable pepetide linker and a maleimide group. The maleimide group in Deruxtecan can react with antibody to form antibody-drug conguates (ADC) such as Trastuzumab deruxtecan (DS-8201a), which is a HER2-targeting antibody-drug conjugate. DS-8201a significantly suppressed tumor growth in an immunocompetent mouse model with human HER2-expressing CT26.WT (CT26.WThHER2) cells. DS-8201a is currently in clinical trials. Synonyms: Deruxtecan Analog; Deruxtecan, Trastuzumab deruxtecan; DS-8201a; DS8201a; DS 8201a; Exatecan derivative; DX-8951 derivative; DX 8951; DX8951; N-[6-(2, 5-Dioxo-2, 5-dihydro-1H-pyrrol-1-yl)hexanoyl]glycylglycyl-L-phenylalanyl-N-[(2-{[(1S, 9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10, 13-dioxo-2, 3, 9, 10, 13, 15-hexahydro-1H, 12H-benzo[de]pyrano[3', 4':6, 7]indolizino[1, 2-b]quinolin-1-yl]amino}-2-oxoethoxy)methyl]glycinamide. Grades: ≥95%. CAS No. 1599440-13-7. Molecular formula: C52H56FN9O13. Mole weight: 1034.05. | |
DSP Crosslinker Quick inquiry Where to buy Suppliers range | DSP Crosslinker is a cleavable ADC linker, used in the synthesis of antibody-drug conjugates (ADCs). Synonyms: Disuccinimido dithiobispropionate; Di(N-succinimidyl) 3,3'-dithiodipropionate. Grades: 98.0 %. CAS No. 57757-57-0. Molecular formula: C14H16N2O8S2. Mole weight: 404.42. | |
DSS Crosslinker Quick inquiry Where to buy Suppliers range | DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Synonyms: Disuccinimidyl suberate; bis(2,5-dioxopyrrolidin-1-yl) octanedioate; Suberic acid bis(N-hydroxysuccinimide ester). Grades: >98.0%. CAS No. 68528-80-3. Molecular formula: C16H20N2O8. Mole weight: 368.34. | |
DTSSP Crosslinker Quick inquiry Where to buy Suppliers range | DTSSP Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Uses: It is a water-soluble, thiol cleavable, homobifunctional and amine-reactive crosslinking agent. Synonyms: 3,3'-Dithiobis(sulphosuccinimidyl propionate); 3-pyrrolidinesulfonic acid, 1,1'-[dithiobis[(1-oxo-3,1-propanediyl)oxy]]bis[2,5-dioxo-. Grades: ≥97.0%. CAS No. 81069-02-5. Molecular formula: C14H16N2O14S4. Mole weight: 564.54. | |
Ethanethioic Acid S-[3-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]propyl] Ester Quick inquiry Where to buy Suppliers range | Ethanethioic Acid S-[3-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]propyl] Ester is an intermediate in the synthesis of heterobifunctional linkers for the conjugation of carbohydrates to protein. Group: Biochemicals. Alternative Names: Thioacetic Acid S-ester with N- (3-Mercaptopropoxy) phthalimide (7CI,8CI); NSC 101750. Grades: Highly Purified. CAS No. 1088-37-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Fmoc-3VVD-OH Quick inquiry Where to buy Suppliers range | Fmoc-3VVD-OH is a cleavable ADC linker used to synthesize antibody-drug conjugations (ADCs). Synonyms: (5S,9S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,9-diisopropyl-12-methoxy-4,10-dimethyl-3,6,8-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valyl-N-[(2R,3S,4S)-1-carboxy-2-methoxy-4-methyl-3-hexanyl]-N-methyl-L-valinamide; L-Valinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valyl-N-[(1S,2S)-1-[(1R)-2-carboxy-1-methoxyethyl]-2-methylbutyl]-N-methyl-; FMOC-3AA-OH. Grades: ≥95%. CAS No. 863971-44-2. Molecular formula: C36H51N3O7. Mole weight: 637.81. | |
Fmoc-Asp-NH2 Quick inquiry Where to buy Suppliers range | Fmoc-Asp-NH2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Synonyms: Fmoc-L-Isoasparagine; Fmoc-Isoasn-OH; Butanoic acid, 4-amino-3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-4-oxo-, (3S)-. Grades: ≥98.0%. CAS No. 200335-40-6. Molecular formula: C19H18N2O5. Mole weight: 354.36. | |
Fmoc-Gly-Gly-OH Quick inquiry Where to buy Suppliers range | Fmoc-Gly-Gly-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Synonyms: N-Fmoc-L-glycylglycine; 2- (2- ( ( ( (9H-Fluoren-9-yl) methoxy) carbonyl) amino) acetamido) acetic acid. Grades: >99.3%. CAS No. 35665-38-4. Molecular formula: C19H18N2O5. Mole weight: 354.36. | |
Fmoc-N-amido-PEG2-acetic acid Quick inquiry Where to buy Suppliers range | Fmoc-AEEA-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Synonyms: Fmoc-NH-PEG2-CH2COOH; Fmoc-8-amino-3,6-dioxaoctanoic acid; [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid; FMOC-AEEA; 12- (9H- Fluoren- 9- yl) - 10- oxo-3, 6, 11- trioxa- 9- azadodecanoic Acid; 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic Acid; 8-(9-Fluorenylmethoxycarbonylamino)-3,6-dioxaoctanoic Acid; 9-Fluorenylmethoxycarbonyl-8-amino-3,6-dioxaoctanoic Acid; 2,7,10-Trioxa-4-azadodecan-12-oic acid, 1-(9H-fluoren-9-yl)-3-oxo-. Grades: 98%. CAS No. 166108-71-0. Molecular formula: C21H23NO6. Mole weight: 385.41. | |
Fmoc-Val-Cit-PAB-PNP Quick inquiry Where to buy Suppliers range | Fmoc-Val-Cit-PAB-PNP is a peptide prodrug linker, is a linker for antibody-drug-conjugation (ADC). Uses: Peptide Inhibitors. CAS No. 863971-53-3. Product ID: R1363. | |
Galα1-3Galβ1-4GlcNAcα1-HDPE Quick inquiry Where to buy Suppliers range | It is a neoglycolipid synthesised by conjugating oligosaccharide via an amino group and a 3-atom linker arm to 1,2-di-O-hexadecyl-sn-glycero-3-phosphoethanolamine (HDPE). Molecular formula: C60H116N3PO22. Mole weight: 1262.73. | |
Galα1-3Galβ1-HDPE Quick inquiry Where to buy Suppliers range | It is a neoglycolipid synthesised by conjugating oligosaccharide via an amino group and a 3-atom linker arm to 1,2-di-O-hexadecyl-sn-glycero-3-phosphoethanolamine (HDPE). Molecular formula: C54H103N2PO17. Mole weight: 1083.37. | |
Galβ1-4GlcNAcβ1-HDPE Quick inquiry Where to buy Suppliers range | It is a neoglycolipid synthesised by conjugating oligosaccharide via an amino group and a 3-atom linker arm to 1,2-di-O-hexadecyl-sn-glycero-3-phosphoethanolamine (HDPE). Molecular formula: C54H106N3PO17. Mole weight: 1100.40. | |
Maleimide-PEG4-NHS Quick inquiry Where to buy Suppliers range | This molecular is a sulfhydryl and amine reactive heterofuncational PEG linker. The chemical bonds that formed through Maleimide-PEG4-NHS linker are very stable. The NHS ester reacts with amino groups at pH 7-9 to form stable amide bond. In addiction, the maleimide reacts with thiol groups at pH 6.5-7.5 to form stable thiol-ether bond. Maleimide-PEG4-NHS is a very useful linker for various biomolecule crosslinking applications (such as to make ADCs (antibody drug conjugates.)). Uses: Useful linker for various biomolecule crosslinking applications. Synonyms: Maleimide-PEG4-NHS; MAL-PEG4-NHS; Maleimide PEG NHS; MAL-PEG-NHS; Maleimido-Tetra(Ethylene Glycol)?-Acetic Acid NHS ester;2,5-dioxopyrrolidin-1-yl 14-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12-tetraoxatetradecanoate. Grades: 98%. CAS No. 1286754-10-6. Molecular formula: C18H24N2O10. Mole weight: 428.39. | |
Maleimide-PEG-FITC Quick inquiry Where to buy Suppliers range | Maleimide-PEG-FITC (MAL-PEG-FITC) is a heterofunctional linker, which has maleimide group on one end for conjugation of thiol-containing ligands, and fluorescent probe (green) on the other end for labeling. Group: Photoactive Polymers. Alternative Names: MAL-PEG-FITC. Product ID: ACMA00018054. | |
Maleimide-PEG-Rhodamine Quick inquiry Where to buy Suppliers range | Maleimide-PEG-Rhodamine (MAL-PEG-RhB) is a heterofunctional linker, which has maleimide group on one end for conjugation of thiol-containing ligands, and fluorescent probe (red) on the other end for labeling. Group: Photoactive Polymers. Alternative Names: MAL-PEG-RhB. Product ID: ACMA00018055. | |
MC-Gly-Gly-Phe-Gly Quick inquiry Where to buy Suppliers range | MC-Gly-Gly-Phe-Gly is a cleavable ADC linker used for antibody-drug conjugates (ADCs). Synonyms: (S)-5-Benzyl-18-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazaoctadecan-1-oic acid. Grades: >98.0%. CAS No. 2413428-36-9. Molecular formula: C25H31N5O8. Mole weight: 529.54. | |
MC-Gly-Gly-Phe-Gly Quick inquiry Where to buy Suppliers range | MC-Gly-Gly-Phe-Gly is a cleavable ADC linker used for antibody-drug conjugates (ADCs). Uses: Peptide Inhibitors. CAS No. 2413428-36-9. Product ID: R1896. | |
MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH Quick inquiry Where to buy Suppliers range | MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Synonyms: Glycinamide,N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]glycylglycyl-L-phenylalanyl-N-[(carboxymethoxy) methyl]-. Grades: >98.0%. CAS No. 1599440-25-1. Molecular formula: C28H36N6O10. Mole weight: 616.62. | |
mDPR-Val-Cit-PAB-MMAE Quick inquiry Where to buy Suppliers range | mDPR-Val-Cit-PAB-MMAE consists the ADCs linker (mDPR-Val-Cit-PAB) and potent tubulin inhibitor (MMAE), mDPR-Val-Cit-PAB-MMAE is an antibody drug conjugate. Synonyms: N-[(2S)-3-Amino-2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl]-L-valyl-N-{4-[(5S,8S,11S,12R)-11-[(2S)-2-butanyl]-12-(2-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenyl-2-propanyl]amino}-1-methoxy-2 ;-methyl-3-oxopropyl]-1-pyrrolidinyl}-2-oxoethyl)-5,8-diisopropyl-4,10-dimethyl-3,6,9-trioxo-2,13-dioxa-4,7,10-triazatetradec-1-yl]phenyl}-N5-carbamoyl-L-ornithinamide; L-Ornithinamide, N-[(2S)-3-amino-2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[(5S,8S,11S,12R)-12-[2-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenyl ethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-oxoethyl]-4,10-dimethyl-5,8-bis(1-methylethyl)-11-[(1S)-1-methylpropyl]-3,6,9-trioxo-2,13-dioxa-4,7,10-triazatetradec-1-yl]phenyl]-. Grades: ≥95%. CAS No. 1491152-26-1. Molecular formula: C65H100N12O15. Mole weight: 1289.561. | |
mDPR-Val-Cit-PAB-MMAE Quick inquiry Where to buy Suppliers range | mDPR-Val-Cit-PAB-MMAE consists the ADCs linker (mDPR-Val-Cit-PAB) and potent tubulin inhibitor (MMAE), mDPR-Val-Cit-PAB-MMAE is an antibody drug conjugate. Uses: Peptide Inhibitors. CAS No. 1491152-26-1. Product ID: R1901. | |
MitoE10 Quick inquiry Where to buy Suppliers range | MitoE10, a mitochondria-targeted antioxidants comprising a lipophilic triphenylphosphonium cation attached to the antioxidant chroman moiety of vitamin E by an alkyl linker, was synthesised starting from 1-hydroxy-11-dodecyne, obtained by the addition of 1-bromononane to lithiated propargyl THP ether followed by triple bond migration using NaH and ethylenediamine. Preliminary biological data demonstrate that MitoE10 shows greater efficacy in preventing lipid peroxidation, mitochondrial oxidative damage and damage to mitochondrial DNA than non-targeted compounds. Synonyms: (10-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)decyl)triphenylphosphonium methanesulfonate; MitoE10; Mito E10; MitoE-10; Vitaman E-triphenylphosphonium conjugate; 1810703-64-0 (mesylate salt); 1810703-63-9 (cation). Grades: >98%. CAS No. 1810703-63-9. Molecular formula: C42H55O5PS. Mole weight: 702.93. | |
mPEG-Biotin Quick inquiry Where to buy Suppliers range | mPEG-biotin can be used for PEGylation by binding to streptavidin and avidin with high affinity and specificity. Biotin is conjugated to a linear PEG through a stable amide linker. Group: Functional PEGs. Alternative Names: Streptavidin binding PEG reagents. Product ID: ACMA00006354. Appearance: Crystalline solid or semi-solid. Storage: -20?, protected from light and moisture. | |
N-Boc-diethanolamine Quick inquiry Where to buy Suppliers range | N-Boc-diethanolamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Synonyms: Tert-Butyl N,N-bis(2-hydroxyethyl)carbamate. Grades: 97 %. CAS No. 103898-11-9. Molecular formula: C9H19NO4. Mole weight: 205.25. | |
N-Butanoyl-L-homoserine lactone Quick inquiry Where to buy Suppliers range | N-Butanoyl-L-homoserine lactone is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm. Synonyms: N-[(3s)-2-Oxotetrahydrofuran-3-Yl]butanamide; (S)-N-(2-Oxotetrahydrofuran-3-yl)butyramide. Grades: >98.0%. CAS No. 67605-85-0. Molecular formula: C8H13NO3. Mole weight: 171.19. | |
NHS-PEG4-azide Quick inquiry Where to buy Suppliers range | NHS-PEG4-azide is a non-cleavable 4-unit PEG linker that can be used to synthesize antibody-conjugated drugs (ADCs). Synonyms: Azido-PEG4-CH2CO2-NHS; N3-PEG4-C2-NHS ester; N3-PEG4-CH2CH2COONHS Ester; Azido-PEG4-NHS ester; N-Succinimidyl 15-Azido-4,7,10,13-tetraoxapentadecanoate; 2,5-Dioxopyrrolidin-1-yl 1-azido-3,6,9,12-tetraoxapentadecan-15-oate; 1-[(1-Azido-15-oxo-3,6,9,12-tetraoxapentadecan-15-yl)oxy]-2,5-pyrrolidinedione; 2,5-Pyrrolidinedione, 1-[(15-azido-1-oxo-4,7,10,13-tetraoxapentadec-1-yl)oxy]-. Grades: ≥98%. CAS No. 944251-24-5. Molecular formula: C15H24N4O8. Mole weight: 388.37. | |
N-Hydroxysulfosuccinimide sodium Quick inquiry Where to buy Suppliers range | N-Hydroxysulfosuccinimide (sodium) is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Synonyms: Sulfo-NHS; Sodium 1-hydroxy-2,5-dioxopyrrolidine-3-sulfonate. Grades: > 98.0 %. CAS No. 106627-54-7. Molecular formula: C4H4NNaO6S. Mole weight: 217.13. | |
N-Methyl-N-[(3-methyldithio)-1-oxopropyl]-L-alanine Quick inquiry Where to buy Suppliers range | N-Methyl-N-[(3-methyldithio)-1-oxopropyl]-L-alanine, a microtubule inhibitor, is a PEG linker used in antibody-drug-conjugation (ADC). Synonyms: (S) -2- (N-Methyl-3- (methyldisulfanyl) propanamido) propanoic acid; L-Alanine, N-methyl-N-[3-(methyldithio)-1-oxopropyl]-; N-Methyl-N-[3-(methyldisulfanyl)propanoyl]-L-alanine. Grades: ≥95%. CAS No. 138148-62-6. Molecular formula: C8H15NO3S2. Mole weight: 237.34. | |
N-Succinimidyl 4- (Maleimidomethyl) cyclohexane-1-carboxylate (SMCC) Quick inquiry Where to buy Suppliers range | A heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. Typically coupled initially to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. Contains 9 atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers. Group: Biochemicals. Alternative Names: 4- (N-Maleimidomethyl) cyclohexane-1-carboxylic Acid N-Hydroxysuccinimide Ester; NSC 344483; SMCC. Grades: Highly Purified. CAS No. 64987-85-5. Pack Sizes: 25mg, 100mg, 250mg, 500mg. US Biological Life Sciences. | Worldwide |
Paclitaxel Succinate Quick inquiry Where to buy Suppliers range | Paclitaxel-Succinic acid is a paclitaxel derivative with a succinic acid linker. The carboxy group ofPaclitaxel-Succinic acid can be used to conjugate with other molecules such as peptides, proteins, antibodies or enzymes, or polymers after activating. Paclitaxel-Succinic acid has been used asa reactant for the preparation of molecular hydrogelators to be used as local delivery systems for chemotherapy, drug delivery and nanodrug research. Uses: A useful agent to make paclitaxel-conjugate for drug delivery, nanodrug research. Synonyms: 2'-O-Succinoylpaclitaxel; 2'-O-Succinylpaclitaxel; 2'-Succinylpaclitaxel; 2'-Succinyltaxol; Paclitaxel 2'-(Hydrogen Succinate); Paclitaxel 2'-Hemisuccinate; [2aR-[2aα, 4β, 4aβ, 6β, 9α(1R*, 2S*), 11α, 12α, 12aα, 12bα]]-Mono[2-(benzoylamino)-1-[[[6, 12b-bis(acetyloxy)-12-(benzoyloxy)-2a, 3, 4, 4a, 5, 6, 9, 10, 11, 12, 12a, 12b-dodecahydro-4, 11-dihydroxy-4a, 8, 13, 13-tetramethyl-5-oxo-7, 11-methano-1H-cyclodeca[3, 4]benz[1, 2-b]oxet-9-yl]oxy]carbonyl]-2-phenylethyl] Ester Butanedioic Acid; Mono[(1R, 2S)-2-(benzoylamino)-1-[[[(2aR, 4S, 4aS, 6R, 9S, 11S, 12S, 12aR, 12bS)-6, 12b-bis(acetyloxy)-12-(benzoyloxy)-2a, 3, 4, 4a, 5, 6, 9, 10, 11, 12, 12a, 12b-dodecahydro-4, 11-dihydroxy-4a, 8, 13, 13-tetramethyl-5-oxo-7, 11-methano-1H-cyclodeca[3, 4]benz[1, 2-b]oxet-9-yl]oxy]carbonyl]-2-phenylethyl] Ester Butanedioic Acid. Grades: 98%. CAS No. 117527-50-1. Molecular formula: C51H55NO17. Mole weight: 953.98. | |
Pomalidomide-C2-NH2 Quick inquiry Where to buy Suppliers range | Pomalidomide-C2-NH2 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 17 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1]. Synonyms: 4-((2-aminoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; SCHEMBL17884390; TQP0427; Cereblon Ligand-Linker Conjugates 15; HY-128846; Pomalidomide-C2-NH2; Pomalidomide-alkylC2-amine; E3 ligase Ligand 17; 4-[(2-Aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride. Grades: > 98%. CAS No. 1957235-66-3. Molecular formula: C15H16N4O4. Mole weight: 316.31. | |
Pomalidomide-C4-NH2 Quick inquiry Where to buy Suppliers range | Pomalidomide-C4-NH2 is a synthetic E3 ligase ligand-linker conjugate that incorporates Pomalidomide-based CRBN ligands and linkers used in PROTAC technology. Synonyms: 4-((4-aminobutyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-[(4-Aminobutyl)amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione; 4-[(4-Aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; 1H-Isoindole-1,3(2H)-dione, 4-[(4-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-; Thalidomide-NH-C4-NH2. Grades: ≥95%. CAS No. 1957236-34-8. Molecular formula: C17H20N4O4. Mole weight: 344.37. |