lipoxygenase Suppliers USA

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15-Lipoxygenase-2 from human, Recombinant Two types of 15-lipoxygenase (15-LO) have been discovered and characterized, both of which metabolize arachidonic acid (AA) to produce 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE). 15-LO-1 oxygenates AA at both C-15 and C-12, whereas 15-LO-2 exclusively oxygenates C-15 of AA. Human 15-LO-2 has a molecular mass of approximately 76 kDa and exhibits approximately 40% identity to the reticulocyte 15-LO-1. Expression of 15-LO-2 appears to be restricted to prostate, lung, skin, and cornea and may play a role in the normal development of these tissues. The protein levels and enzymatic activity of 15-LO-2 are both down-regulated in prostate cancer compared with normal and benign prostate tissues, implicating a possible protective role for 15-LO-2 against tumor formation. Group: Enzymes. Synonyms: Arachidonate 15-lipoxygenase type II; 15-lipoxygenase-2; 15-LO-2; 15-LOX-2; ALOX15B. Enzyme Commission Number: EC 1.13.11.33. Purity: > 95% estimated by SDS-PAGE. Lipoxygenase. Mole weight: 76 kDa. Activity: 234.15 U/ml. Stability: As supplied, 6 months from the QC date provided on the Certificate of Analysis, when stored properly. Storage: at -80°C. Form: PBS, pH 7.4, 1 mM DTT and 20% glycerol. Source: E. coli. Species: Human. Arachidonate 15-lipoxygenase type II; 15-lipoxygenase-2; 15-LO-2; 15-LOX-2; ALOX15B. Cat No: NATE-1248. Creative Enzymes
15-Lipoxygenase Inhibitor 1 15-Lipoxygenases (15-LO) inhibitor 1 is a heterocyclic pyrimidobenzothiazine compound that inhibits 15-LO with an IC50 value of 18 μM. Synonyms: 15-LO Inhibitor 1; 4-methyl-2-(4-methylpiperazin-1-yl)-5H-pyrimido[4,5-b][1,4]benzothiazine. Grades: ≥95%. CAS No. 928853-86-5. Molecular formula: C16H19N5S. Mole weight: 313.4. BOC Sciences 10
5-Lipoxygenase from human, Recombinant Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is an enzyme that in humans is encoded by the ALOX5 gene. Arachidonate 5-lipoxygenase is a member of the lipoxygenase family of enzymes. It transforms EFAs into leukotrienes and is a current target for pharmaceutical intervention in a number of diseases. Group: Enzymes. Synonyms: Arachidonate 5-lipoxygenase; ALOX5; 5-lipoxygenase; 5-LOX; 5-LO; 5LPG; LOG5. Enzyme Commission Number: EC 1.13.11.34. CAS No. 80619-02-9. Lipoxygenase. Mole weight: 78 kDa. Activity: 1,259.96 U/ml. Stability: As supplied, 6 months from the QC date provided on the Certificate of Analysis, when stored properly. Storage: at -80°C. Form: A solution in 100 mM Tris-HCl, pH 8.0, containing 5 mM EGTA, 1mM CaCl2, and 30% glycerol. Source: S9 insect cells. Species: Human. Arachidonate 5-lipoxygenase; ALOX5; 5-lipoxygenase; 5-LOX; 5-LO; 5LPG; LOG5. Cat No: NATE-1249. Creative Enzymes
arachidonate 12-lipoxygenase The product is rapidly reduced to the corresponding 12S-hydroxy compound. Group: Enzymes. Synonyms: Δ12-lipoxygenase; 12-lipoxygenase; 12Δ-lipoxygenase; C-12 lipoxygenase; 12S-lipoxygenase; leukotriene A4 synthase; LTA4 synthase. Enzyme Commission Number: EC 1.13.11.31. CAS No. 82391-43-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0551; arachidonate 12-lipoxygenase; EC 1.13.11.31; 82391-43-3; Δ12-lipoxygenase; 12-lipoxygenase; 12Δ-lipoxygenase; C-12 lipoxygenase; 12S-lipoxygenase; leukotriene A4 synthase; LTA4 synthase. Cat No: EXWM-0551. Creative Enzymes
arachidonate 15-lipoxygenase The product is rapidly reduced to the corresponding 15S-hydroxy compound. Group: Enzymes. Synonyms: 15-lipoxygenase; linoleic acid ω6-lipoxygenase; ω6 lipoxygenase. Enzyme Commission Number: EC 1.13.11.33. CAS No. 82249-77-2. Lipoxygenase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0552; arachidonate 15-lipoxygenase; EC 1.13.11.33; 82249-77-2; 15-lipoxygenase; linoleic acid ω6-lipoxygenase; ω6 lipoxygenase. Cat No: EXWM-0552. Creative Enzymes
arachidonate 5-lipoxygenase Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme (EC 1.13.11.34) that in humans is encoded by the ALOX5 gene. Arachidonate 5-lipoxygenase is a member of the lipoxygenase family of enzymes. It transforms EFA substrates into leukotrienes as well as a wide range of other biologically active products. ALOX5 is a current target for pharmaceutical intervention in a number of diseases. Group: Enzymes. Synonyms: leukotriene-A4 synthase; Δ5-lipoxygenase; 5Δ-lipoxygenase; arachidonic 5-lipoxygenase; arachidonic acid 5-lipoxygenase; C-5-lipoxygenase; LTA synthase; leukotriene A4 synthase. Enzyme Commission Number: EC 1.13.11.34. CAS No. 80619-02-9. Lipoxygenase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0553; arachidonate 5-lipoxygenase; EC 1.13.11.34; 80619-02-9; leukotriene-A4 synthase; Δ5-lipoxygenase; 5Δ-lipoxygenase; arachidonic 5-lipoxygenase; arachidonic acid 5-lipoxygenase; C-5-lipoxygenase; LTA synthase; leukotriene A4 synthase. Cat No: EXWM-0553. Creative Enzymes
arachidonate 8-lipoxygenase From the coral Pseudoplexaura porosa. Group: Enzymes. Synonyms: 8-lipoxygenase; 8(R)-lipoxygenase. Enzyme Commission Number: EC 1.13.11.40. CAS No. 100900-72-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0560; arachidonate 8-lipoxygenase; EC 1.13.11.40; 100900-72-9; 8-lipoxygenase; 8(R)-lipoxygenase. Cat No: EXWM-0560. Creative Enzymes
linoleate 10R-lipoxygenase The enzyme is involved in biosynthesis of oxylipins, which affect sporulation, development, and pathogenicity of Aspergillus spp. Group: Enzymes. Synonyms: 10R-DOX; (10R)-dioxygenase; 10R-dioxygenase. Enzyme Commission Number: EC 1.13.11.62. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0582; linoleate 10R-lipoxygenase; EC 1.13.11.62; 10R-DOX; (10R)-dioxygenase; 10R-dioxygenase. Cat No: EXWM-0582. Creative Enzymes
linoleate 11-lipoxygenase The product (9Z,12Z)-(11S)-11-hydroperoxyoctadeca-9,12-dienoate, is converted, more slowly, into (9Z,11E)-(13R)-13-hydroperoxyoctadeca-9,11-dienoate. The enzyme from the fungus Gaeumannomyces graminis requires Mn2+. It also acts on α-linolenate, whereas γ-linolenate is a poor substrate. Oleate and arachidonate are not substrates. Group: Enzymes. Synonyms: linoleate dioxygenase, manganese lipoxygenase. Enzyme Commission Number: EC 1.13.11.45. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0563; linoleate 11-lipoxygenase; EC 1.13.11.45; linoleate dioxygenase, manganese lipoxygenase. Cat No: EXWM-0563. Creative Enzymes
linoleate 13S-lipoxygenase Contains nonheme iron. A common plant lipoxygenase that oxidizes linoleate and α-linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C-13 position with (S)-configuration. This enzyme produces precursors for several important compounds, including the plant hormone jasmonic acid. EC 1.13.11.58, linoleate 9S-lipoxygenase, catalyses a similar reaction at the second available position of these fatty acids. Group: Enzymes. Synonyms: 13-lipoxidase; carotene oxidase; 13-lipoperoxidase; fat oxidase; 13-lipoxydase; lionoleate:O2 13-oxidoreductase. Enzyme Commission Number: EC 1.13.11.12. CAS No. 9029-60-1. Lipoxygenase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0532; linoleate 13S-lipoxygenase; EC 1.13.11.12; 9029-60-1; 13-lipoxidase; carotene oxidase; 13-lipoperoxidase; fat oxidase; 13-lipoxydase; lionoleate:O2 13-oxidoreductase. Cat No: EXWM-0532. Creative Enzymes
linoleate 8R-lipoxygenase The enzyme contains heme. The bifunctional enzyme from Aspergillus nidulans uses different heme domains to catalyse two separate reactions. Linoleic acid is oxidized within the N-terminal heme peroxidase domain to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate, which is subsequently isomerized by the C-terminal P-450 heme thiolate domain to (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate (cf. EC 5.4.4.5, 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase). The bifunctional enzyme from Gaeumannomyces graminis also catalyses the oxidation of linoleic acid to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate, but its second domain isomerizes it to (7S,8S,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate (cf. EC 5.4.4.6, 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase). Group: Enzymes. Synonyms: linoleic acid 8R-dioxygenase; 5,8-LDS (bifunctional enzyme); 7,8-LDS (bifunctional enzyme); 5,8-linoleate diol synthase (bifunctio. Enzyme Commission Number: EC 1.13.11.60. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0580; linoleate 8R-lipoxygenase; EC 1.13.11.60; linoleic acid 8R-dioxygenase; 5,8-LDS (bifunctional enzyme); 7,8-LDS (bifunctional enzyme); 5,8-linoleate diol synthase (bifunctional enzyme); 7,8-linoleate diol synthase (bifunctional enzyme); PpoA. Cat No: EXWM-0580. Creative Enzymes
linoleate 9S-lipoxygenase Contains nonheme iron. A common plant lipoxygenase that oxidizes linoleate and α-linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C9 position with (S)-configuration. The enzyme plays a physiological role during the early stages of seedling growth. The enzyme from Arabidopsis thaliana shows comparable activity towards linoleate and linolenate. EC 1.13.11.12 (linoleate 13S-lipoxygenase) catalyses a similar reaction at another position of these fatty acids. Group: Enzymes. Synonyms: 9-lipoxygenase; 9S-lipoxygenase; linoleate 9-lipoxygenase; LOX1 (gene name); 9S-LOX. Enzyme Commission Number: EC 1.13.11.58. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0577; linoleate 9S-lipoxygenase; EC 1.13.11.58; 9-lipoxygenase; 9S-lipoxygenase; linoleate 9-lipoxygenase; LOX1 (gene name); 9S-LOX. Cat No: EXWM-0577. Creative Enzymes
linolenate 9R-lipoxygenase In cyanobacteria the enzyme is involved in oxylipin biosynthesis. The enzyme also converts linoleate to (9R,10E,12Z)-9-hydroperoxyoctadeca-10,12-dienoate. Group: Enzymes. Synonyms: NspLOX; (9R)-LOX; linoleate 9R-dioxygenase. Enzyme Commission Number: EC 1.13.11.61. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0581; linolenate 9R-lipoxygenase; EC 1.13.11.61; NspLOX; (9R)-LOX; linoleate 9R-dioxygenase. Cat No: EXWM-0581. Creative Enzymes
oleate 10S-lipoxygenase Binds Fe2+. The enzyme isolated from the bacterium Pseudomonas sp. 42A2 has similar activity with all the three Δ9 fatty acids. cf. EC 1.13.11.62, linoleate 10R-lipoxygenase. Group: Enzymes. Synonyms: 10S-DOX; (10S)-dioxygenase; 10S-dioxygenase. Enzyme Commission Number: EC 1.13.11.77. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0597; oleate 10S-lipoxygenase; EC 1.13.11.77; 10S-DOX; (10S)-dioxygenase; 10S-dioxygenase. Cat No: EXWM-0597. Creative Enzymes
11-?Keto-?beta-?boswellic acid 11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 11-Keto-β-boswellic acid. CAS No. 17019-92-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N2056. MedChemExpress MCE
12(S)-HETE 12(S)-HETE is the 12-lipoxygenase metabolite of arachidonic acid and has a mitogenic effect on cancer cell proliferation. 12(S)-HETE induces tyrosine phosphorylation of cellular proteins, promotes ERK and P38 MAPK phosphorylation, increases DNA synthesis, and stimulates the proliferation of pancreatic cancer cells [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 54397-83-0. Pack Sizes: 100 μg (312.04 μM * 1 mL in Ethanol). Product ID: HY-124404A. MedChemExpress MCE
12(S)-HETE-19,20-alkyne 12(S)-HETE-19,20-alkyne is fluorescent labelled 12(S)-HETE which is the predominant lipoxygenase product of mammalian platelets. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25μg, 50μg. Molecular Formula: C20H28O3, Molecular Weight: 316.43. US Biological Life Sciences. USBiological 9
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12(S)-HpETE 12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons6 and inhibits Ca2+/calmodulin-dependent protein kinase II from rat brain cortex. Synonyms: 12-Hydroperoxyicosatetraenoate; (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoic acid. Grades: ≥98%. CAS No. 71774-10-2. Molecular formula: C20H32O4. Mole weight: 336.5. BOC Sciences 10
13(S)-HpOTrE(γ) 13(S)-HpOTrE(γ) is a monohydroxy PUFA produced by the action of soybean lipoxygenase-1 (LO-1) on γ-linolenic acid. Further action of soybean LO-1 converts 13(S)-HpOTrE(γ) to all four isomers of 6,13-DiHOTrE. Synonyms: 13(S)-Hydroperoxy-6Z,9Z,11E-octadecatrienoic acid; (6Z,9Z,11E,13S)-13-hydroperoxyoctadeca-6,9,11-trienoic acid. Grades: ≥98%. CAS No. 121107-97-9. Molecular formula: C18H30O4. Mole weight: 310.4. BOC Sciences 10
14,15-Dehydro leukotriene B4 14,15-Dehydro leukotriene B4 is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway. Synonyms: 14,15-dehydro LTB4; 5S,12R-dihydroxy-6Z,8E,10E-eicosatrien-14-ynoic acid. Grades: ≥97%. CAS No. 114616-11-4. Molecular formula: C20H30O4. Mole weight: 334.5. BOC Sciences 10
15-KETE (15-oxo-ETE) 15-KETE (15-oxo-ETE) is a major metabolite of arachidonic acid that is formed through the Lipoxygenase pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 81416-72-0. Pack Sizes: 50ug, 100ug. Molecular Formula: C20H30O3, Molecular Weight: 318.45. US Biological Life Sciences. USBiological 9
Worldwide
15(S)-HEDE 15(S)-HEDE has been identified in psoriatic skin scale extracts (undetermined 15-OH stereochemistry) and inhibits 5-LO (5-lipoxygenase) with an IC50 of 26 μM. Synonyms: (15S)-15-hydroxyicosa-11,13-dienoic acid. Grades: ≥98%. CAS No. 92693-04-4. Molecular formula: C20H36O3. Mole weight: 324.5. BOC Sciences 10
15(S)-HEPE 15(S)-HEPE is a monohydroxy fatty acid. 15(S)-HEPE is biosynthesized from eicosapentaenoic acid by 15-lipoxygenase (15-LO). Serum levels of 15(S)-HEPE are elevated in patients with asthma. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 15(S)-hydroxy-Eicosapentaenoic acid; 15(S)-hydroxy EPA. CAS No. 86282-92-0. Pack Sizes: 25 μg (314.02 μM * 250 μL in Ethanol); 50 μg (314.02 μM * 500 μL in Ethanol). Product ID: HY-130675A. MedChemExpress MCE
15(S)-HpETE 15(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid. Synonyms: (S)-15-hpete; 15-Hydroperoxyicosatetraenoate; 15-Hydroperoxyeicosatetraenoate. Grades: ≥98%. CAS No. 70981-96-3. Molecular formula: C20H32O4. Mole weight: 336.5. BOC Sciences 10
15(S)-HPETE 15(S)-HPETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid. It is either metabolized to 14,15-leukotriene A41 or reduced to 15(S)-HETE by peroxidases.2,1 15(S)-HpETE mediates a number of biological functions including the induction of c-fos and c-jun, and activation of AP-1.3 15(S)-HpETE inhibits prostacyclin synthesis in porcine aortic microsomes and bovine endothelial cells, and can cause the suicide inactivation of porcine 12-LO. Uses: Scientific research. Group: Signaling pathways. CAS No. 70981-96-3. Pack Sizes: 25 μg (297.20 μM * 250 μL in Ethanol). Product ID: HY-113438. MedChemExpress MCE
17-Oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid 17-Oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity. Synonyms: EFOX; 17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-DHA; 17-oxo-DHA; (4Z,7Z,10Z,13Z,15E,19Z)-17-Oxodocosahexaenoic acid. Grades: ≥90%. CAS No. 1233715-28-0. Molecular formula: C22H30O3. Mole weight: 342.5. BOC Sciences 10
17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid Docosapentaenoic acid (DPA) is a ω-3 fatty acid found in fish oils. 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DPA that is produced endogenously by aspirin-enhanced COX-2 activity. Synonyms: EFOX; 17-oxo-DPA; 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-DPA; 17-keto-(7Z,10Z,13Z,15E,19Z)-docosapentaenoic acid. Grades: ≥95%. CAS No. 1233715-33-7. Molecular formula: C22H32O3. Mole weight: 344.5. BOC Sciences 10
1- (Aminomethyl) cyclopropanol 1- (Aminomethyl) cyclopropanol is a useful chemical reactant used in the preparation of 5-lipoxygenase activating protein (FLAP) inhibitors for the treatment of inflammatory diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 74592-33-9. Pack Sizes: 100mg, 250mg. Molecular Formula: C4H9NO, Molecular Weight: 87.12. US Biological Life Sciences. USBiological 9
Worldwide
1-(Benzo[b]thien-2-yl)ethanol 1-(Benzo[b]thien-2-yl)ethanol is an intermediate used to prepare amino sugar and related sugar derivatives of indolopyrrolocarbazole s as antitumors. It is also an impurity of Zileuton (Z420000), an inhibitor of 5-lipoxygenase, the initial enzyme in the biosynthesis of leukotrienes from Arachidonic Acid. Zileuton is used as an antiasthmatic. Group: Biochemicals. Grades: Highly Purified. CAS No. 51868-95-2. Pack Sizes: 5mg, 25mg. Molecular Formula: C10H10OS, Molecular Weight: 178.25. US Biological Life Sciences. USBiological 9
Worldwide
1H-Pyrazole-3-carbonyl Chloride 1H-Pyrazole-3-carbonyl Chloride is a compound used in the preparation of N-Substituted pyrazole-3-carboxamides as inhibitors of human 15-lipoxygenase. Group: Biochemicals. Grades: Highly Purified. CAS No. 717871-84-6. Pack Sizes: 500mg, 1g. Molecular Formula: C4H3ClN2O, Molecular Weight: 130.53. US Biological Life Sciences. USBiological 9
Worldwide
1-Naphthyl 3,5-dinitrobenzoate 1-Naphthyl 3,5-dinitrobenzoate has been identified as a dual 5-lipoxygenase and microsomal prostaglandin E synthase-1 inhibitor with IC50 values of 1 and 3.6 μM, respectively. Synonyms: 1-(3,5-Dinitrobenzoyloxy)naphthalene; 1-Naphthalonol 3,5-dinitrobenzoate. Grades: ≥98%. CAS No. 93261-39-3. Molecular formula: C17H10N2O6. Mole weight: 338.3. BOC Sciences 10
1-Phenylpiperidin-3-one 1-Phenylpiperidin-3-one is used in the synthetic preparation of lipoxygenase inhibition structure. Group: Biochemicals. Grades: Highly Purified. CAS No. 148494-90-0. Pack Sizes: 250mg, 2.5g. Molecular Formula: C11H13NO, Molecular Weight: 175.23. US Biological Life Sciences. USBiological 9
Worldwide
1-Phenylpiperidin-3-one-d5 1-Phenylpiperidin-3-one-d5 is the isotope analog of 1-Phenylpiperidin-3-one. 1-Phenylpiperidin-3-one is used in the synthetic preparation of lipoxygenase inhibition structure. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C11H8D5NO, Molecular Weight: 180.26. US Biological Life Sciences. USBiological 9
Worldwide
2,5-Di-tert-butylhydroquinone 2,5-Di-tert-butylhydroquinone (DTBHQ), the indirect food additive, regulates the activity of 5-lipoxygenase as well as the activity of COX-2 ( IC 50 =1.8 and 14.1 μM for 5-LO and COX-2, respectively) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 88-58-4. Pack Sizes: 10 mM * 1 mL; 25 g; 50 g. Product ID: HY-W012399. MedChemExpress MCE
2-Amino-4-(1-naphthyl)thiazole 2-Amino-4-(1-naphthyl)thiazole is a reagent used in the synthesis of 2-substituted ethenesulfonic acid ester derivatives as PTP1B inhibitors. Also used as a reagent in the preparation of pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors for the treatment of inflammation and various cancers. Group: Biochemicals. Grades: Highly Purified. CAS No. 56503-96-9. Pack Sizes: 100mg, 250mg. Molecular Formula: C13H10N2S, Molecular Weight: 226.3. US Biological Life Sciences. USBiological 9
Worldwide
2-Bromo-1-furan-2-yl-ethanone 2-Bromo-1-furan-2-yl-ethanone is a reagent that is used in the preparation of diaryldi hydropyrrolizine derivatives and their activity as cyclooxygenase and lipoxygenase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 15109-94-1. Pack Sizes: 100mg, 250mg. Molecular Formula: C6H5BrO2, Molecular Weight: 189.01. US Biological Life Sciences. USBiological 10
Worldwide
2-Heptyl-4-quinolone It is produced by the strain of Pseudomonas pyocyanea, P. aeruginosa, P. methanica. It has weak anti-gram-positive bacterial activity. It can inhibit the microsomal respiratory chain and 5-lipoxygenase of cytochrome BC1 complex, and antagonize the antibacterial activity of dihydrostreptomycin. Synonyms: 2-Heptyl-4-hydroxyquinolinone; Antibiotic MY 12-62a; 2-Heptyl-4-(1H)-quinolinone; 2-heptylquinolin-4(1H)-one; 2-heptyl-4-quinolone; HHQ; 4(1H)-Quinolone, 2-heptyl-; 2-n-Heptyl-4-quinolone; 4-Hydroxy-2-heptylquinolone; Dihydroakutine; Pseudane VII. Grades: 95%. CAS No. 40522-46-1. Molecular formula: C16H21NO. Mole weight: 243.34. BOC Sciences 6
2-Hydroxy-3,4-dihydroisoquinolin-1(2H)-one 2-Hydroxy-3,4-dihydroisoquinolin-1(2H)-one is a block chemical in organic syntheses. It can be used in the preparation of Cyclic Aryl Hydroxamic Acids that inhibit arachidonate 5-lipoxygenase. Group: Biochemicals. Grades: Highly Purified. CAS No. 116526-30-8. Pack Sizes: 5mg, 10mg. Molecular Formula: C9H9NO2, Molecular Weight: 163.169999999999. US Biological Life Sciences. USBiological 10
Worldwide
2-Hydroxy-3-nitrobenzaldehyde 2-Hydroxy-3-nitrobenzaldehyde is an intermediate used to prepare benzoxazole derivatives as melatonin receptor agonists. It is also used in the synthesis of benzenesulfonamide derivatives with 12-lipoxygenase inhibitory activities. Group: Biochemicals. Grades: Highly Purified. CAS No. 5274-70-4. Pack Sizes: 1g, 2.5g. Molecular Formula: C7H5NO4, Molecular Weight: 167.12. US Biological Life Sciences. USBiological 10
Worldwide
2-Hydroxy-6-pentadecyl Benzoic Acid 2-Hydroxy-6-pentadecyl Benzoic Acid, is a compound that is used to treat agriculture from various fruit insects. Derivative of this molecule has been also shown to be a potent activator of human 5-lipoxygenases (5-LOX). Group: Biochemicals. Grades: Highly Purified. CAS No. 16611-84-0. Pack Sizes: 10mg, 25mg. Molecular Formula: C22H36O3, Molecular Weight: 348.52. US Biological Life Sciences. USBiological 10
Worldwide
2-Oleoyl glycerol 2-Oleoyl glycerol (2-OG) is a natural monoacylglycerol with an 18:1 oleoyl group at the sn-2 position of glycerol. 2-OG, like 2-arachidonoyl glycerol, is metabolized by monoacylglycerol lipase, but, unlike 2-AG, it is not metabolized by cyclooxygenases or lipoxygenases. Synonyms: 2-Monoolein; 2-OG; 2-Monooleoylglycerol; 2-Glyceryl monooleate; Glyceryl 2-oleate; 2-(9Z-octadecenoyl)-sn-glycerol. Grades: >99%. CAS No. 3443-84-3. Molecular formula: C21H40O4. Mole weight: 356.54. BOC Sciences 10
2-Phenoxymethyl-7-phenylmethoxy-1H-benzimidazole A 2-substituted benzimidazole as inhibitor of cell-free RBL-1-5-lipoxygenase. Group: Biochemicals. Grades: Highly Purified. CAS No. 1215342-45-2. Pack Sizes: 10mg. US Biological Life Sciences. USBiological 2
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(2R,4R)-trans-Ketoconazole (2R,4R)-trans-Ketoconazole is an isomer of Ketoconazole (K186000). Ketoconazole inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. It has antimetastatic and antineoplastic activity and is an orally active 5-lipoxygenase and thromboxane synthase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 142128-58-3. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C26H28Cl2N4O4, Molecular Weight: 531.429999999999. US Biological Life Sciences. USBiological 10
Worldwide
(2R,4R)-trans-Ketoconazole-d8 (2R,4R)-trans-Ketoconazole-d8 is the isotope labelled analog of (2R,4R)-trans-Ketoconazole (K186015); an isomer of Ketoconazole (K186000). Ketoconazole inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. It has antimetastatic and antineoplastic activity and is an orally active 5-lipoxygenase and thromboxane synthase inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C26H20D8Cl2N4O4, Molecular Weight: 539.48. US Biological Life Sciences. USBiological 10
Worldwide
2-TEDC 2-TEDC is a potent inhibitor of 5-, 12-, and 15-lipoxygenase (IC50 = 0.09, 0.013 and 0.5 μM, respectively). Synonyms: 2-TEDC; 2 TEDC; 2TEDC; 2-(1-Thienyl)ethyl 3,4-dihydroxybenzylidenecyanoacetate. Grades: ≥99% by HPLC. CAS No. 132465-10-2. Molecular formula: C16H13NO4S. Mole weight: 315.34. BOC Sciences 10
3-Bromomethyl-5-methylpyridine 3-Bromomethyl-5-methylpyridine is an intermediate used to prepare redox-active 5-lipoxygenase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 120276-47-3. Pack Sizes: 50mg, 100mg. Molecular Formula: C7H8BrN, Molecular Weight: 186.05. US Biological Life Sciences. USBiological 10
Worldwide
5,8,11-Eicosatriynoic acid 5,8,11-Eicosatriynoic acid (ETI) is a lipoxygenase inhibitor that blocks LTC4 biosynthesis in mast cell tumor cells [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ETI. CAS No. 13488-22-7. Pack Sizes: 1 mg. Product ID: HY-124252. MedChemExpress MCE
5,8,11-Eicosatriynoic acid 5,8,11-ETI is a nonselective inhibitor of lipoxygenases. It inhibits 12-LO in human platelets with an ID50 value of 24 μM. Synonyms: 5,8,11-ETI; Eicosa-5,8,11-triynoic acid. Grades: ≥99%. CAS No. 13488-22-7. Molecular formula: C20H28O2. Mole weight: 300.4. BOC Sciences 10
(±)5-HETE lactone (±) 5-HETE Lactone is a unique marker for 5-lipoxygenase activation. (±) 5-HETE Lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of (±)5-HETE. It inhibits 5-LO (5-lipoxygenase) (IC50=27 μM) from rat basophilic leukemia cells. The lactone form is several times more potent. Synonyms: 6-pentadeca-1,3,6,9-tetraenyloxan-2-one; 6-[(1E,3Z,6Z,9Z)-pentadeca-1,3,6,9-tetraenyl]oxan-2-one. Grades: ≥98%. CAS No. 73279-37-5. Molecular formula: C20H30O2. Mole weight: 302.5. BOC Sciences 10
5-LOX-IN-4 5-LOX-IN-4 is a 5-Lipoxygenase inhibitor extracted from patent EP 331232 A2, table 4, compound example 4.10. Uses: Scientific research. Group: Signaling pathways. CAS No. 125235-15-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00308. MedChemExpress MCE
8(S)-HEPE 8(S)-HEPE is a monohydroxy fatty acid produced by lipoxygenase oxidation of EPA. It acts to promote hatching of barnacle eggs at 10 nM, although it is not clearly identified as the natural egg hatching factor. Uses: Scientific research. Group: Signaling pathways. CAS No. 118492-81-2. Pack Sizes: 25 μg (314.02 μM * 250 μL in Ethanol); 50 μg (314.02 μM * 500 μL in Ethanol). Product ID: HY-126108A. MedChemExpress MCE
8(S)-HETE 8(S)-HETE is a major lipoxygenase product in PMA-treated murine epidermis. Synonyms: 8S-hydroxy-5Z,9E,11Z,14Z-eicosatetraenoic acid. Grades: ≥98%. CAS No. 98462-03-4. Molecular formula: C20H32O3. Mole weight: 320.5. BOC Sciences 10
9,12-octadecadienoate 8-hydroperoxide 8R-isomerase The enzyme contains heme. The bifunctional enzyme from Aspergillus nidulans uses different heme domains to catalyse two separate reactions. Linoleic acid is oxidized within the N-terminal heme peroxidase domain to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate (cf. EC 1.13.11.60, linoleate 8R-lipoxygenase), which is subsequently isomerized to (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate within the C-terminal P-450 heme thiolate domain. Group: Enzymes. Synonyms: 5,8-LDS (bifunctional enzyme); 5,8-linoleate diol synthase (bifunctional enzyme); 8-hydroperoxide isomerase; (8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((5S,8R,9Z,12Z)-5,8-dihydroxy-9,12-octadecadienoate-forming); PpoA. Enzyme Commission Number: EC 5.4.4.5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5546; 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase; EC 5.4.4.5; 5,8-LDS (bifunctional enzyme); 5,8-linoleate diol synthase (bifunctional enzyme); 8-hydroperoxide isomerase; (8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((5S,8R,9Z,12Z)-5,8-dihydroxy-9,12-octadecadienoate-forming); PpoA. Cat No: EXWM-5546. Creative Enzymes
9,12-octadecadienoate 8-hydroperoxide 8S-isomerase The enzyme contains heme. The bifunctional enzyme from Gaeumannomyces graminis catalyses the oxidation of linoleic acid to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate (cf. EC 1.13.11.60, linoleate 8R-lipoxygenase), which is then isomerized to (7S,8S,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate. Group: Enzymes. Synonyms: 8-hydroperoxide isomerase (ambiguous); (8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((7S,8S,9Z,12Z)-7,8-dihydroxy-9,12-octadecadienoate-forming). Enzyme Commission Number: EC 5.4.4.6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5547; 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase; EC 5.4.4.6; 8-hydroperoxide isomerase (ambiguous); (8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((7S,8S,9Z,12Z)-7,8-dihydroxy-9,12-octadecadienoate-forming). Cat No: EXWM-5547. Creative Enzymes
9,12-Octadecadiynoic acid 9,12-Octadecadiynoic acid is an inhibitor of both COX and lipoxygenase. Synonyms: Ro 3-1314; 9a-12a-Octadecadiynoic acid. Grades: ≥98%. CAS No. 2012-14-8. Molecular formula: C18H28O2. Mole weight: 276.4. BOC Sciences 10
Abietic acid Abietic acid, an orally active diterpene isolated from Colophony, displays significant anti-proliferative, anti-inflammatory, anti-obesity effect, bacteriostatic, cell cycle arresting and pro-apoptotic activities. Abietic acid inhibits lipoxygenase activity for allergy. Abietic acid enhances cell migration and tube formation in HUVECs. Abietic acid induces significant angiogenic potential, which is associated with upregulation of extracellular signal-regulated kinase (ERK) and p38 expression. Abietic acid attenuates sepsis-induced lung injury by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway to inhibit M1 macrophage polarization. Abietic acid exhibits a positive effect against liver injury by attenuating inflammation and ferroptosis. Abietic acid shows accelerated wound closure in a mouse model of cutaneous wounds. Abietic acid significantly reduces the proliferation and growth of NSCLC cells by IKKβ inhibition.Additionally, Abietic acid ameliorates psoriasis-like inflammation and modulates gut microbiota in mice. Abietic acid is promising for research in non-small-cell lung cancer (NSCLC), liver injury-related deseases and psoriasis [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Natural products. CAS No. 514-10-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N6871. MedChemExpress MCE
Acetohydroxamic acid Acetohydroxamic acid is the inhibitor for bacterial and plant urease that can be used for chronic urinary tract infections. Acetohydroxamic acid selectively inhibits arachidonic acid 5-lipoxygenase that is useful in the research of asthma. Acetohydroxamic acid inhibits the formation of advanced glycation end products, and reduces oxidative stress and inflammatory responses. Acetohydroxamic acid exhibits antiviral activity against HIV [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N-Hydroxyacetamide. CAS No. 546-88-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B1235. MedChemExpress MCE
Acetone 2,4-Dinitrophenylhydrazone Acetone 2,4-Dinitrophenylhydrazone is a dinitrophenylhydrazone (DNPH) derivative of an aliphatic ketone found in mainstream cigarette smoke. Acetone 2,4-Dinitrophenylhydrazone showed inhibitory activity towards soybean lipoxygenase and renal prostaglandin synthetase. Group: Biochemicals. Alternative Names: 2-Propanone 2- (2, 4-Dinitrophenyl) hydrazone; 2-Propanone (2, 4-Dinitrophenyl) hydrazone; Acetone (2, 4-Dinitrophenyl) hydrazone; 1-(2,4-Dinitrophenyl)-2-(propan-2-ylidene)hydrazine; NSC 131450; NSC 6120. Grades: Highly Purified. CAS No. 1567-89-1. Pack Sizes: 1g. US Biological Life Sciences. USBiological 1
Worldwide
Acetylcysteine Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti- influenza virus activities. In addition, Acetylcysteine ??is the most stable form of cysteine ??during drug delivery and can be used in disulfidptosis studies [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Natural products. Alternative Names: N-Acetylcysteine; N-Acetyl-L-cysteine; NAC. CAS No. 616-91-1. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g; 10 g. Product ID: HY-B0215. MedChemExpress MCE
Allene Oxide Synthase from Parthenium argentatum, Recombinant Potent anti-oxidant enzyme to remove lipid hydroperoxides in biological samples. Allene oxide synthase converts lipoxygenase derived fatty acid hydroperoxides to unstable allene epoxides. In plants, allene oxide is a precursor of jasmonic acid, which is important for growth regulation. Applications: Allene oxide synthase is a potent anti-oxidant enzyme used to remove lipid hydroperoxides in various biological samples. it may also be used to study stress induced gene expression in plants. Group: Enzymes. Synonyms: hydroperoxide isomerase; linoleate hydroperoxide isomerase; linoleic acid hydroperoxide isomerase; HPI; (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydr. Enzyme Commission Number: EC 4.2.1.92. AOS. Activity: 25,000-40,000 units/mg protein. Storage: Store at -20°C. Form: Supplied as a solution in phosphate buffered sale pH 7.2. Source: E. coli. Species: Parthenium argentatum. hydroperoxide isomerase; linoleate hydroperoxide isomerase; linoleic acid hydroperoxide isomerase; HPI; (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase; (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]; allene oxide synthase; AOS; EC 4.2.1.92; hydroperoxide dehydratase. Pack: vial of ~300 μg. Cat No: NATE-0808. Creative Enzymes
(-)-allo-Protolichesterinic acid (-)-allo-Protolichesterinic acid can inhibit 5-lipoxygenase in vitro. CAS No. 22800-27-7. Molecular formula: C19H32O4. Mole weight: 324.45. BOC Sciences 5
α-Boswellic Acid The principal constitutents of frankincense (olibanum). A specific, nonredox inhibitor of 5-lipoxygenase used to treat inflammation. Group: Biochemicals. Alternative Names: (3α,4 β)-3-Hydroxyolean-12-en-23-oic Acid; 3α-hydroxyolean-12-en-24-oic Acid; 3α-Acetyl-α-boswellic Acid; alpha-Boswellic Acid. Grades: Highly Purified. CAS No. 471-66-9. Pack Sizes: 2.5mg. US Biological Life Sciences. USBiological 2
Worldwide
AM679 AM679 is a drug which acts as a selective inhibitor of 5-Lipoxygenase-activating protein (FLAP). This protein is involved in the production of cysteinyl leukotrienes which are involved in inflammation, and AM679 has anti-inflammatory effects in animal studies. AM679 also showed potent inhibition of leukotrienes in human blood and in a rodent bronchoalvelolar lavage (BAL) challenge model. Research showed AM679 reduces inflammation in the respiratory syncytial virus-infected mouse eye. Synonyms: AM-679; AM 679; AM679; UNII-65KJ8P7M9D; CHEMBL595092; SCHEMBL503239; 65KJ8P7M9D. Grades: >98%. CAS No. 1206880-66-1. Molecular formula: C40H44N4O5S. Mole weight: 692.87. BOC Sciences 2
Anacardic acid Potent histone acetyltransferase (HAT) inhibitor. Antibacterial. SUMOylation inhibitor. Lipoxygenase inhibitor. NF-kappaB inhibitor. Anti-tumor compound. Anti-inflammatory. Apoptosis inducer. Antiproliferative. Group: Biochemicals. Grades: Highly Purified. CAS No. 16611-84-0. Pack Sizes: 5mg, 25mg. Molecular Formula: C22H36O3. US Biological Life Sciences. USBiological 3
Worldwide
Atreleuton Atreleuton, a kind of urea compound, has been found to be a 5-lipoxygenase inhibitor as well as Leukotriene B4 receptor antagonist that could probably be useful in study of sorts of diseases like asthma and acute coronary syndromes. It has already been discontinued by VIA Pharmaceuticals. Uses: Lipoxygenase inhibitors. Synonyms: Atreleuton; ABT-761; ABT 761; VIA 2291; VIA-2291; VIA2291; A-85761; Abbott-85761; Atreleuton [USAN]; UNII-U301T88E1M; ABT 761; 1-[(2R)-4-[5-[(4-fluorophenyl)methyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxyurea. Grades: 98%. CAS No. 154355-76-7. Molecular formula: C16H15FN2O2S. Mole weight: 318.37. BOC Sciences 2
Atreleuton Glucuronide Atreleuton Glucuronide is an esteemed compound of profound significance, used for studying afflictions of inflammation and autoimmune disorders. Its unparalleled prowess lies in the inhibition of 5-lipoxygenase activity, thereby efficaciously studying the research and development of leukotrienes. Molecular formula: C22H22FN2O8S. Mole weight: 493.48. BOC Sciences
Atuliflapon Atuliflapon is a novel 5-lipoxygenase activating protein (FLAP) inhibitor for the treatment of coronary artery disease. Synonyms: (1R,2R)-2-[4-(5-methyl-1H-pyrazol-3-yl)benzoyl]-N-(4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cyclohexane-1-carboxamide; AZD5718; Cyclohexanecarboxamide, 2-[4-(5-methyl-1H-pyrazol-3-yl)benzoyl]-N-(4,5,6,7-tetrahydro-4-oxopyrazolo[1,5-a]pyrazin-3-yl)-, (1R,2R)-; AZD-5718; AZD 5718. Grades: ≥98% by HPLC. CAS No. 2041075-86-7. Molecular formula: C24H26N6O3. Mole weight: 446.50. BOC Sciences 2
Avarol Antibacterial against selected Gram-positive strains, antifungal. Anticancer compound. Antileukemic. Antimitotic agent. Antiviral compound. Inhibits HIV activity. Anti-inflammatory. Synovial phospholipase A2, cyclooxygenase and lipoxygenase inhibitor. Modulator of superoxide dismutase and glutathione peroxidase. Platelet aggregation inhibitor. Anti-psoriatic, mediated by inhibition of TNF-alpha generation and NF-kappaB activation. Group: Biochemicals. Alternative Names: NSC 306951. Grades: Highly Purified. CAS No. 55303-98-5. Pack Sizes: 1mg. Molecular Formula: C21H30O2. US Biological Life Sciences. USBiological 3
Worldwide
BAY-X-1005 BAY-X 1005 is a potent and selective FLAP (5-lipoxygenase-activating protein) inhibitor. BAY-X 1005 is also a selective inhibitor of leukotriene synthesis. BAY-X1005 inhibited LTB4 synthesis with IC50 values of 220 nM for isolated PMNL of human and inhibited LTC4 synthesis with IC50 value of 210 nM in mouse macrophages. Phase-III for Myocardial infarction in USA was suspended in 2006. Uses: Myocardial infarction. Synonyms: BAY-X-1005; BAY X 1005; BAYX1005; Veliflapon;DG-031; DG 031; DG031; (2R)-2-cyclopentyl-2-[4-(quinolin-2-ylmethoxy)phenyl]acetic acid. Grades: >98 %. CAS No. 128253-31-6. Molecular formula: C23H23NO3. Mole weight: 361.43. BOC Sciences 10
Benoxaprofen Benoxaprofen (LRCL 3794) is a potent and long-acting anti-inflammatory and antipyretic compound. Benoxaprofen is a relatively weak inhibitor of cyclooxygenase in in vitro systems, inhibits lipoxygenase in other systems, and inhibits monocyte migration in some animal models of inflammation [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LRCL 3794. CAS No. 51234-28-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13568. MedChemExpress MCE

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