Lipoxygenase Suppliers USA
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Product | Description | |
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15-Lipoxygenase Inhibitor 1 Quick inquiry Where to buy Suppliers range | 15-Lipoxygenases (15-LO) inhibitor 1 is a heterocyclic pyrimidobenzothiazine compound that inhibits 15-LO with an IC50 value of 18 μM. Synonyms: 15-LO Inhibitor 1; 4-methyl-2-(4-methylpiperazin-1-yl)-5H-pyrimido[4,5-b][1,4]benzothiazine. Grades: ≥95%. CAS No. 928853-86-5. Molecular formula: C16H19N5S. Mole weight: 313.4. | |
12(S)-HETE-19,20-alkyne Quick inquiry Where to buy Suppliers range | 12(S)-HETE-19,20-alkyne is fluorescent labelled 12(S)-HETE which is the predominant lipoxygenase product of mammalian platelets. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25μg, 50μg. Molecular Formula: C20H28O3, Molecular Weight: 316.43. US Biological Life Sciences. | Worldwide |
12(S)-HpETE Quick inquiry Where to buy Suppliers range | 12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons6 and inhibits Ca2+/calmodulin-dependent protein kinase II from rat brain cortex. Synonyms: 12-Hydroperoxyicosatetraenoate; (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoic acid. Grades: ≥98%. CAS No. 71774-10-2. Molecular formula: C20H32O4. Mole weight: 336.5. | |
13(S)-HpOTrE(γ) Quick inquiry Where to buy Suppliers range | 13(S)-HpOTrE(γ) is a monohydroxy PUFA produced by the action of soybean lipoxygenase-1 (LO-1) on γ-linolenic acid. Further action of soybean LO-1 converts 13(S)-HpOTrE(γ) to all four isomers of 6,13-DiHOTrE. Synonyms: 13(S)-Hydroperoxy-6Z,9Z,11E-octadecatrienoic acid; (6Z,9Z,11E,13S)-13-hydroperoxyoctadeca-6,9,11-trienoic acid. Grades: ≥98%. CAS No. 121107-97-9. Molecular formula: C18H30O4. Mole weight: 310.4. | |
14,15-Dehydro leukotriene B4 Quick inquiry Where to buy Suppliers range | 14,15-Dehydro leukotriene B4 is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway. Synonyms: 14,15-dehydro LTB4; 5S,12R-dihydroxy-6Z,8E,10E-eicosatrien-14-ynoic acid. Grades: ≥97%. CAS No. 114616-11-4. Molecular formula: C20H30O4. Mole weight: 334.5. | |
15-KETE (15-oxo-ETE) Quick inquiry Where to buy Suppliers range | 15-KETE (15-oxo-ETE) is a major metabolite of arachidonic acid that is formed through the Lipoxygenase pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 81416-72-0. Pack Sizes: 50ug, 100ug. Molecular Formula: C20H30O3, Molecular Weight: 318.45. US Biological Life Sciences. | Worldwide |
15(S)-HEDE Quick inquiry Where to buy Suppliers range | 15(S)-HEDE has been identified in psoriatic skin scale extracts (undetermined 15-OH stereochemistry) and inhibits 5-LO (5-lipoxygenase) with an IC50 of 26 μM. Synonyms: (15S)-15-hydroxyicosa-11,13-dienoic acid. Grades: ≥98%. CAS No. 92693-04-4. Molecular formula: C20H36O3. Mole weight: 324.5. | |
15(S)-HpETE Quick inquiry Where to buy Suppliers range | 15(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid. Synonyms: (S)-15-hpete; 15-Hydroperoxyicosatetraenoate; 15-Hydroperoxyeicosatetraenoate. Grades: ≥98%. CAS No. 70981-96-3. Molecular formula: C20H32O4. Mole weight: 336.5. | |
17-Oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid Quick inquiry Where to buy Suppliers range | 17-Oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity. Synonyms: EFOX; 17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-DHA; 17-oxo-DHA; (4Z,7Z,10Z,13Z,15E,19Z)-17-Oxodocosahexaenoic acid. Grades: ≥90%. CAS No. 1233715-28-0. Molecular formula: C22H30O3. Mole weight: 342.5. | |
17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid Quick inquiry Where to buy Suppliers range | Docosapentaenoic acid (DPA) is a ω-3 fatty acid found in fish oils. 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DPA that is produced endogenously by aspirin-enhanced COX-2 activity. Synonyms: EFOX; 17-oxo-DPA; 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-DPA; 17-keto-(7Z,10Z,13Z,15E,19Z)-docosapentaenoic acid. Grades: ≥95%. CAS No. 1233715-33-7. Molecular formula: C22H32O3. Mole weight: 344.5. | |
1- (Aminomethyl) cyclopropanol Quick inquiry Where to buy Suppliers range | 1- (Aminomethyl) cyclopropanol is a useful chemical reactant used in the preparation of 5-lipoxygenase activating protein (FLAP) inhibitors for the treatment of inflammatory diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 74592-33-9. Pack Sizes: 100mg, 250mg. Molecular Formula: C4H9NO, Molecular Weight: 87.12. US Biological Life Sciences. | Worldwide |
1-(Benzo[b]thien-2-yl)ethanol Quick inquiry Where to buy Suppliers range | 1-(Benzo[b]thien-2-yl)ethanol is an intermediate used to prepare amino sugar and related sugar derivatives of indolopyrrolocarbazole s as antitumors. It is also an impurity of Zileuton (Z420000), an inhibitor of 5-lipoxygenase, the initial enzyme in the biosynthesis of leukotrienes from Arachidonic Acid. Zileuton is used as an antiasthmatic. Group: Biochemicals. Grades: Highly Purified. CAS No. 51868-95-2. Pack Sizes: 5mg, 25mg. Molecular Formula: C10H10OS, Molecular Weight: 178.25. US Biological Life Sciences. | Worldwide |
1H-Pyrazole-3-carbonyl Chloride Quick inquiry Where to buy Suppliers range | 1H-Pyrazole-3-carbonyl Chloride is a compound used in the preparation of N-Substituted pyrazole-3-carboxamides as inhibitors of human 15-lipoxygenase. Group: Biochemicals. Grades: Highly Purified. CAS No. 717871-84-6. Pack Sizes: 500mg, 1g. Molecular Formula: C4H3ClN2O, Molecular Weight: 130.53. US Biological Life Sciences. | Worldwide |
1-Naphthyl 3,5-dinitrobenzoate Quick inquiry Where to buy Suppliers range | 1-Naphthyl 3,5-dinitrobenzoate has been identified as a dual 5-lipoxygenase and microsomal prostaglandin E synthase-1 inhibitor with IC50 values of 1 and 3.6 μM, respectively. Synonyms: 1-(3,5-Dinitrobenzoyloxy)naphthalene; 1-Naphthalonol 3,5-dinitrobenzoate. Grades: ≥98%. CAS No. 93261-39-3. Molecular formula: C17H10N2O6. Mole weight: 338.3. | |
1-Phenylpiperidin-3-one Quick inquiry Where to buy Suppliers range | 1-Phenylpiperidin-3-one is used in the synthetic preparation of lipoxygenase inhibition structure. Group: Biochemicals. Grades: Highly Purified. CAS No. 148494-90-0. Pack Sizes: 250mg, 2.5g. Molecular Formula: C11H13NO, Molecular Weight: 175.23. US Biological Life Sciences. | Worldwide |
1-Phenylpiperidin-3-one-d5 Quick inquiry Where to buy Suppliers range | 1-Phenylpiperidin-3-one-d5 is the isotope analog of 1-Phenylpiperidin-3-one. 1-Phenylpiperidin-3-one is used in the synthetic preparation of lipoxygenase inhibition structure. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C11H8D5NO, Molecular Weight: 180.26. US Biological Life Sciences. | Worldwide |
2-Amino-4-(1-naphthyl)thiazole Quick inquiry Where to buy Suppliers range | 2-Amino-4-(1-naphthyl)thiazole is a reagent used in the synthesis of 2-substituted ethenesulfonic acid ester derivatives as PTP1B inhibitors. Also used as a reagent in the preparation of pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors for the treatment of inflammation and various cancers. Group: Biochemicals. Grades: Highly Purified. CAS No. 56503-96-9. Pack Sizes: 100mg, 250mg. Molecular Formula: C13H10N2S, Molecular Weight: 226.3. US Biological Life Sciences. | Worldwide |
2-Bromo-1-furan-2-yl-ethanone Quick inquiry Where to buy Suppliers range | 2-Bromo-1-furan-2-yl-ethanone is a reagent that is used in the preparation of diaryldi hydropyrrolizine derivatives and their activity as cyclooxygenase and lipoxygenase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 15109-94-1. Pack Sizes: 100mg, 250mg. Molecular Formula: C6H5BrO2, Molecular Weight: 189.01. US Biological Life Sciences. | Worldwide |
2-Heptyl-4-quinolone Quick inquiry Where to buy Suppliers range | It is produced by the strain of Pseudomonas pyocyanea, P. aeruginosa, P. methanica. It has weak anti-gram-positive bacterial activity. It can inhibit the microsomal respiratory chain and 5-lipoxygenase of cytochrome BC1 complex, and antagonize the antibacterial activity of dihydrostreptomycin. Synonyms: 2-Heptyl-4-hydroxyquinolinone; Antibiotic MY 12-62a; 2-Heptyl-4-(1H)-quinolinone; 2-heptylquinolin-4(1H)-one; 2-heptyl-4-quinolone; HHQ; 4(1H)-Quinolone, 2-heptyl-; 2-n-Heptyl-4-quinolone; 4-Hydroxy-2-heptylquinolone; Dihydroakutine; Pseudane VII. Grades: 95%. CAS No. 40522-46-1. Molecular formula: C16H21NO. Mole weight: 243.34. | |
2-Hydroxy-3,4-dihydroisoquinolin-1(2H)-one Quick inquiry Where to buy Suppliers range | 2-Hydroxy-3,4-dihydroisoquinolin-1(2H)-one is a block chemical in organic syntheses. It can be used in the preparation of Cyclic Aryl Hydroxamic Acids that inhibit arachidonate 5-lipoxygenase. Group: Biochemicals. Grades: Highly Purified. CAS No. 116526-30-8. Pack Sizes: 5mg, 10mg. Molecular Formula: C9H9NO2, Molecular Weight: 163.169999999999. US Biological Life Sciences. | Worldwide |
2-Hydroxy-3-nitrobenzaldehyde Quick inquiry Where to buy Suppliers range | 2-Hydroxy-3-nitrobenzaldehyde is an intermediate used to prepare benzoxazole derivatives as melatonin receptor agonists. It is also used in the synthesis of benzenesulfonamide derivatives with 12-lipoxygenase inhibitory activities. Group: Biochemicals. Grades: Highly Purified. CAS No. 5274-70-4. Pack Sizes: 1g, 2.5g. Molecular Formula: C7H5NO4, Molecular Weight: 167.12. US Biological Life Sciences. | Worldwide |
2-Hydroxy-6-pentadecyl Benzoic Acid Quick inquiry Where to buy Suppliers range | 2-Hydroxy-6-pentadecyl Benzoic Acid, is a compound that is used to treat agriculture from various fruit insects. Derivative of this molecule has been also shown to be a potent activator of human 5-lipoxygenases (5-LOX). Group: Biochemicals. Grades: Highly Purified. CAS No. 16611-84-0. Pack Sizes: 10mg, 25mg. Molecular Formula: C22H36O3, Molecular Weight: 348.52. US Biological Life Sciences. | Worldwide |
2-Oleoyl glycerol Quick inquiry Where to buy Suppliers range | 2-Oleoyl glycerol (2-OG) is a natural monoacylglycerol with an 18:1 oleoyl group at the sn-2 position of glycerol. 2-OG, like 2-arachidonoyl glycerol, is metabolized by monoacylglycerol lipase, but, unlike 2-AG, it is not metabolized by cyclooxygenases or lipoxygenases. Synonyms: 2-Monoolein; 2-OG; 2-Monooleoylglycerol; 2-Glyceryl monooleate; Glyceryl 2-oleate; 2-(9Z-octadecenoyl)-sn-glycerol. Grades: >99%. CAS No. 3443-84-3. Molecular formula: C21H40O4. Mole weight: 356.54. | |
2-Phenoxymethyl-7-phenylmethoxy-1H-benzimidazole Quick inquiry Where to buy Suppliers range | A 2-substituted benzimidazole as inhibitor of cell-free RBL-1-5-lipoxygenase. Group: Biochemicals. Grades: Highly Purified. CAS No. 1215342-45-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
(2R,4R)-trans-Ketoconazole Quick inquiry Where to buy Suppliers range | (2R,4R)-trans-Ketoconazole is an isomer of Ketoconazole (K186000). Ketoconazole inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. It has antimetastatic and antineoplastic activity and is an orally active 5-lipoxygenase and thromboxane synthase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 142128-58-3. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C26H28Cl2N4O4, Molecular Weight: 531.429999999999. US Biological Life Sciences. | Worldwide |
(2R,4R)-trans-Ketoconazole-d8 Quick inquiry Where to buy Suppliers range | (2R,4R)-trans-Ketoconazole-d8 is the isotope labelled analog of (2R,4R)-trans-Ketoconazole (K186015); an isomer of Ketoconazole (K186000). Ketoconazole inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. It has antimetastatic and antineoplastic activity and is an orally active 5-lipoxygenase and thromboxane synthase inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C26H20D8Cl2N4O4, Molecular Weight: 539.48. US Biological Life Sciences. | Worldwide |
2-TEDC Quick inquiry Where to buy Suppliers range | 2-TEDC is a potent inhibitor of 5-, 12-, and 15-lipoxygenase (IC50 = 0.09, 0.013 and 0.5 μM, respectively). Synonyms: 2-TEDC; 2 TEDC; 2TEDC; 2-(1-Thienyl)ethyl 3,4-dihydroxybenzylidenecyanoacetate. Grades: ≥99% by HPLC. CAS No. 132465-10-2. Molecular formula: C16H13NO4S. Mole weight: 315.34. | |
3-Bromomethyl-5-methylpyridine Quick inquiry Where to buy Suppliers range | 3-Bromomethyl-5-methylpyridine is an intermediate used to prepare redox-active 5-lipoxygenase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 120276-47-3. Pack Sizes: 50mg, 100mg. Molecular Formula: C7H8BrN, Molecular Weight: 186.05. US Biological Life Sciences. | Worldwide |
5,8,11-Eicosatriynoic acid Quick inquiry Where to buy Suppliers range | 5,8,11-ETI is a nonselective inhibitor of lipoxygenases. It inhibits 12-LO in human platelets with an ID50 value of 24 μM. Synonyms: 5,8,11-ETI; Eicosa-5,8,11-triynoic acid. Grades: ≥99%. CAS No. 13488-22-7. Molecular formula: C20H28O2. Mole weight: 300.4. | |
(±)5-HETE lactone Quick inquiry Where to buy Suppliers range | (±) 5-HETE Lactone is a unique marker for 5-lipoxygenase activation. (±) 5-HETE Lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of (±)5-HETE. It inhibits 5-LO (5-lipoxygenase) (IC50=27 μM) from rat basophilic leukemia cells. The lactone form is several times more potent. Synonyms: 6-pentadeca-1,3,6,9-tetraenyloxan-2-one; 6-[(1E,3Z,6Z,9Z)-pentadeca-1,3,6,9-tetraenyl]oxan-2-one. Grades: ≥98%. CAS No. 73279-37-5. Molecular formula: C20H30O2. Mole weight: 302.5. | |
8(S)-HETE Quick inquiry Where to buy Suppliers range | 8(S)-HETE is a major lipoxygenase product in PMA-treated murine epidermis. Synonyms: 8S-hydroxy-5Z,9E,11Z,14Z-eicosatetraenoic acid. Grades: ≥98%. CAS No. 98462-03-4. Molecular formula: C20H32O3. Mole weight: 320.5. | |
9,12-Octadecadiynoic acid Quick inquiry Where to buy Suppliers range | 9,12-Octadecadiynoic acid is an inhibitor of both COX and lipoxygenase. Synonyms: Ro 3-1314; 9a-12a-Octadecadiynoic acid. Grades: ≥98%. CAS No. 2012-14-8. Molecular formula: C18H28O2. Mole weight: 276.4. | |
Acetone 2,4-Dinitrophenylhydrazone Quick inquiry Where to buy Suppliers range | Acetone 2,4-Dinitrophenylhydrazone is a dinitrophenylhydrazone (DNPH) derivative of an aliphatic ketone found in mainstream cigarette smoke. Acetone 2,4-Dinitrophenylhydrazone showed inhibitory activity towards soybean lipoxygenase and renal prostaglandin synthetase. Group: Biochemicals. Alternative Names: 2-Propanone 2- (2, 4-Dinitrophenyl) hydrazone; 2-Propanone (2, 4-Dinitrophenyl) hydrazone; Acetone (2, 4-Dinitrophenyl) hydrazone; 1-(2,4-Dinitrophenyl)-2-(propan-2-ylidene)hydrazine; NSC 131450; NSC 6120. Grades: Highly Purified. CAS No. 1567-89-1. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
(-)-allo-Protolichesterinic acid Quick inquiry Where to buy Suppliers range | (-)-allo-Protolichesterinic acid can inhibit 5-lipoxygenase in vitro. CAS No. 22800-27-7. Molecular formula: C19H32O4. Mole weight: 324.45. | |
α-Boswellic Acid Quick inquiry Where to buy Suppliers range | The principal constitutents of frankincense (olibanum). A specific, nonredox inhibitor of 5-lipoxygenase used to treat inflammation. Group: Biochemicals. Alternative Names: (3α,4 β)-3-Hydroxyolean-12-en-23-oic Acid; 3α-hydroxyolean-12-en-24-oic Acid; 3α-Acetyl-α-boswellic Acid; alpha-Boswellic Acid. Grades: Highly Purified. CAS No. 471-66-9. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
AM679 Quick inquiry Where to buy Suppliers range | AM679 is a drug which acts as a selective inhibitor of 5-Lipoxygenase-activating protein (FLAP). This protein is involved in the production of cysteinyl leukotrienes which are involved in inflammation, and AM679 has anti-inflammatory effects in animal studies. AM679 also showed potent inhibition of leukotrienes in human blood and in a rodent bronchoalvelolar lavage (BAL) challenge model. Research showed AM679 reduces inflammation in the respiratory syncytial virus-infected mouse eye. Synonyms: AM-679; AM 679; AM679; UNII-65KJ8P7M9D; CHEMBL595092; SCHEMBL503239; 65KJ8P7M9D. Grades: >98%. CAS No. 1206880-66-1. Molecular formula: C40H44N4O5S. Mole weight: 692.87. | |
Anacardic acid Quick inquiry Where to buy Suppliers range | Potent histone acetyltransferase (HAT) inhibitor. Antibacterial. SUMOylation inhibitor. Lipoxygenase inhibitor. NF-kappaB inhibitor. Anti-tumor compound. Anti-inflammatory. Apoptosis inducer. Antiproliferative. Group: Biochemicals. Grades: Highly Purified. CAS No. 16611-84-0. Pack Sizes: 5mg, 25mg. Molecular Formula: C22H36O3. US Biological Life Sciences. | Worldwide |
Atreleuton Quick inquiry Where to buy Suppliers range | Atreleuton, a kind of urea compound, has been found to be a 5-lipoxygenase inhibitor as well as Leukotriene B4 receptor antagonist that could probably be useful in study of sorts of diseases like asthma and acute coronary syndromes. It has already been discontinued by VIA Pharmaceuticals. Uses: Lipoxygenase inhibitors. Synonyms: Atreleuton; ABT-761; ABT 761; VIA 2291; VIA-2291; VIA2291; A-85761; Abbott-85761; Atreleuton [USAN]; UNII-U301T88E1M; ABT 761; 1-[(2R)-4-[5-[(4-fluorophenyl)methyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxyurea. Grades: 98%. CAS No. 154355-76-7. Molecular formula: C16H15FN2O2S. Mole weight: 318.37. | |
Atreleuton Glucuronide Quick inquiry Where to buy Suppliers range | Atreleuton Glucuronide is an esteemed compound of profound significance, used for studying afflictions of inflammation and autoimmune disorders. Its unparalleled prowess lies in the inhibition of 5-lipoxygenase activity, thereby efficaciously studying the research and development of leukotrienes. Molecular formula: C22H22FN2O8S. Mole weight: 493.48. | |
Atuliflapon Quick inquiry Where to buy Suppliers range | Atuliflapon is a novel 5-lipoxygenase activating protein (FLAP) inhibitor for the treatment of coronary artery disease. Synonyms: (1R,2R)-2-[4-(5-methyl-1H-pyrazol-3-yl)benzoyl]-N-(4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cyclohexane-1-carboxamide; AZD5718; Cyclohexanecarboxamide, 2-[4-(5-methyl-1H-pyrazol-3-yl)benzoyl]-N-(4,5,6,7-tetrahydro-4-oxopyrazolo[1,5-a]pyrazin-3-yl)-, (1R,2R)-; AZD-5718; AZD 5718. Grades: ≥98% by HPLC. CAS No. 2041075-86-7. Molecular formula: C24H26N6O3. Mole weight: 446.50. | |
Avarol Quick inquiry Where to buy Suppliers range | Antibacterial against selected Gram-positive strains, antifungal. Anticancer compound. Antileukemic. Antimitotic agent. Antiviral compound. Inhibits HIV activity. Anti-inflammatory. Synovial phospholipase A2, cyclooxygenase and lipoxygenase inhibitor. Modulator of superoxide dismutase and glutathione peroxidase. Platelet aggregation inhibitor. Anti-psoriatic, mediated by inhibition of TNF-alpha generation and NF-kappaB activation. Group: Biochemicals. Alternative Names: NSC 306951. Grades: Highly Purified. CAS No. 55303-98-5. Pack Sizes: 1mg. Molecular Formula: C21H30O2. US Biological Life Sciences. | Worldwide |
BAY-X-1005 Quick inquiry Where to buy Suppliers range | BAY-X 1005 is a potent and selective FLAP (5-lipoxygenase-activating protein) inhibitor. BAY-X 1005 is also a selective inhibitor of leukotriene synthesis. BAY-X1005 inhibited LTB4 synthesis with IC50 values of 220 nM for isolated PMNL of human and inhibited LTC4 synthesis with IC50 value of 210 nM in mouse macrophages. Phase-III for Myocardial infarction in USA was suspended in 2006. Uses: Myocardial infarction. Synonyms: BAY-X-1005; BAY X 1005; BAYX1005; Veliflapon;DG-031; DG 031; DG031; (2R)-2-cyclopentyl-2-[4-(quinolin-2-ylmethoxy)phenyl]acetic acid. Grades: >98 %. CAS No. 128253-31-6. Molecular formula: C23H23NO3. Mole weight: 361.43. | |
Butyrolactone II Quick inquiry Where to buy Suppliers range | Butyrolactone II is an antibiotic and it is weak cytotoxic towards bacterial and cancer cell lines. It is also a 5-Lipoxygenase (5-LOX) inhibitor and has shown DPPH (2,2-diphenyl-1-picrylhydrazyl) radical-scavening activity. Synonyms: (2R)-2,5-Dihydro-4-hydroxy-3-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-5-oxo-2-furancarboxylic Acid Methyl Ester. Grades: >95%. CAS No. 87414-44-6. Molecular formula: C19H16O7. Mole weight: 356.33. | |
BW 755C Quick inquiry Where to buy Suppliers range | Constitutive cyclooxygenase (COX-1) is present in cells under physiological conditions, whereas COX-2 is induced by some cytokines, mitogens, and endotoxin in pathological conditions, such as inflammation. Since 5-lipoxygenase (5-LO) oxidizes arachidonic acid to 5-hydroperoxyeicosatetraenoic acid. BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways. It inhibits 5-LO with IC50s of 0.75 μM, COX-1 with IC50s of 0.65 μg/ml, and COX-2 with IC50s of 1.2 μg/ml. BW 755C may also inhibit other LO pathways in vivo. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: BW755C; BW-755C; 1H-Pyrazol-3-amine, 4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-; 4,5-Dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine; 1-(3-Trifluoromethylphenyl)-4,5-dihydro-1H-pyrazol-3-amine; 3-Amino-1-[3-(trifluoromethyl)phenyl]-2-pyrazoline; 3-Amino-1-[3-(trifluoromethyl)phenyl]pyrazoline; 3-Amino-1-[m-(trifluoromethyl)phenyl]-2-pyrazoline; Compound BW 755C. Grades: ≥95%. CAS No. 66000-40-6. Molecular formula: C10H10F3N3. Mole weight: 229.20. | |
BW-B 70C Quick inquiry Where to buy Suppliers range | BW B70C is a potent and selective inhibitor of 5-lipoxygenase (5-LO). 5-LO is an enzyme that transforms essential fatty acids (EFAs) into leukotrienes and is activated by 5-lipoxygenase activating protein (FLAP). BW-B 70C had high potency and long duration in vivo and was considered as potential anti-asthma drug. It was reported that BW B70C blocks leukotriene C4 synthesis by alveolar macrophages, which decreases the migration for leukocyte to the airway lumen. BW B70C didn't affect vascular leucocyte margination and the blood levels of secreted phospholipase A2 and TNF-&alpha. Synonyms: N-[3-[3-(-Fluorophenoxy)phenyl]-1-methyl-2-propenyl]-N-hydroxyurea. Grades: ≥98%. CAS No. 134470-38-5. Molecular formula: C17H17FN2O3. Mole weight: 316.33. | |
Carbazomycin C Quick inquiry Where to buy Suppliers range | Carbazomycin C is a bacterial metabolite originally isolated from Streptomyces and it has diverse biological activities. It is active against S. aureus, B. anthracis, B. subtilis, and M. flavus (MICs = 50, 25, 100, and 50 μg/ml, respectively), the fungi T. asteroides and T. mentagrophytes (MICs = 25 and 100 μg/ml, respectively), and P. falciparum (IC50 = 2.1 μg/ml). Carbazomycin C is cytotoxic to MCF-7, KB, and NCI H187 cells (IC50s = 9.8, 21.4, and 8.2 μg/ml, respectively). It also inhibits 5-lipoxygenase (5-LO) activity in RBL-1 cell extracts (IC50 = 1.9 μM). Synonyms: 4-Hydroxy-3,6-dimethoxy-1,2-dimethylcarbazole. Grades: >95% by HPLC. CAS No. 108073-62-7. Molecular formula: C16H17NO3. Mole weight: 271.31. | |
Cardanol monoene Quick inquiry Where to buy Suppliers range | Cardanol monoene is also known as anacardic acid (C15:1). It inhibits the linoleic acid peroxidation catalyzed by soybean lipoxygenase-1 with an IC50 of 6.8 mM. Cardanol monoene is also a phenol found in cashew nut shell liquid that reversibly inhibits tyrosinase with an IC50 value of 56 μM in vitro. It halts the cell cycle at the S phase and inhibits proliferation dose- and time-dependently in M14 melanoma cells (IC50s = 23.15 and 12.30 μM after 24 and 48 hours of treatment, respectively). A mixture of cardanol mono-, di-, and triene is used to synthesize cardanol-metal complexes that inhibit uropathogenic E. coli biofilm formation. Synonyms: Cardanol C15:1; 6[8'(Z)-pentadecenyl]salicylic acid. Grades: ≥98%. CAS No. 501-26-8. Molecular formula: C21H34O. Mole weight: 302.5. | |
CAY10606 Quick inquiry Where to buy Suppliers range | Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme that in humans is encoded by the ALOX5 gene. 5-LO initiates the synthesis of leukotrienes (LTs) from arachidonic acid, primarily in certain leukocyte populations. CAY10606 is a potent, reversible inhibitor of 5-LO, both in cell-free assays (IC50 = 86 nM) and in intact neutrophils (IC50 = 230 nM). It prevents the production of LTs in whole blood, whether 5-LO is activated with the calcium ionophore A23187 with IC50 of 1.6 μM. Synonyms: CAY 10606; CAY-10606. Grades: ≥98%. CAS No. 1159576-98-3. Molecular formula: C22H18ClNO3. Mole weight: 379.8. | |
CAY10649 Quick inquiry Where to buy Suppliers range | Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme that in humans is encoded by the ALOX5 gene. 5-LO initiates the synthesis of (LTs) from arachidonic acid, primarily in certain leukocyte populations. CAY10649 is a thiazolinone compound that demonstrates direct inhibition of 5-lipoxygenase (5-LO) product formation in intact polymorphonuclear leukocytes (PMNL) with IC50 of 0.28 μM. Synonyms: CAY 10649; CAY-10649. Grades: ≥98%. CAS No. 1272519-89-7. Molecular formula: C17H12ClNO2S. Mole weight: 329.8. | |
CAY10698 Quick inquiry Where to buy Suppliers range | Platelet-type 12-lipoxygenase (12-LO) catalyzes the formation of 12-HpETE from arachidonic acid, which has been found to be expressed in various tumor cells. CAY10698 is an inhibitor of 12-LO with an IC50 value of 5.1 uM. It shows potenital applicaiton in biological characterization for development of potential 12-LO inhibitors. Synonyms: CAY 10698; CAY-10698. Grades: ≥98%. CAS No. 684236-01-9. Molecular formula: C17H17N3O4S2. Mole weight: 391.5. | |
Chebulagic acid Quick inquiry Where to buy Suppliers range | Chebulagic acid is a polyphenol and tannin that has been found in T. chebula and has diverse biological activities. It is an inhibitor of COX-1, COX-2, and 5-lipoxygenase (5-LO; IC50s = 15, 0.92, and 2.1 μM, respectively) as well as α-glucosidase and 15-LO (IC50s = 0.05 and 24.9 μM, respectively). Chebulagic acid inhibit the LPS-induced upregulation of TNF-α and IL-1β in a dose- and time-dependent manner. And it can also inhibit the production of NO, prostaglandin E2 (PGE2), and reactive oxygen species (ROS), and nuclear translocation of NF-κB in RAW 264.7 macrophages in a concentration-dependent manner. Chebulagic acid also show a protective effect against 1-methyl-4-phenylpyridinium (MPP+) - induce cytotoxicity which mimics the pathological symptom of Parkinson's disease. Uses: Topoisomerase i inhibitors. Synonyms: β-D-glucopyranose; Cyclic 3,6-[(1R)-4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate] 1-(3,4,5-trihydroxybenzoate); Cyclic 2?2:4?1-ester with (2S)-2-[(3S,4S)-5-carboxy-3,4-dihydro-3,7,8-trihydroxy-2-oxo-2H-1-benzopyran-4-yl]butanedioic acid. Grades: ≥98%. CAS No. 23094-71-5. Molecular formula: C41H30O27. Mole weight: 954.66. | |
CJ-13610 Quick inquiry Where to buy Suppliers range | CJ-13610 is an inhibitor of 5-lipoxygenase (5-LO). It inhibits 5-LO product formation in human polymorphonuclear leukocytes (PMNLs) challenged with A23187 in vitro. It also inhibits 5-LO product formation induced by phosphorylation in PMNLs and HeLa cells. Synonyms: 4-[3-[4-(2-methylimidazol-1-yl)phenyl]sulfanylphenyl]oxane-4-carboxamide; Tetrahydro-4-[3-[[4-(2-methyl-1H-imidazol-1-yl)phenyl]thio]phenyl]-2H-pyran-4-carboxamide. Grades: ≥98%. CAS No. 179420-17-8. Molecular formula: C22H23N3O2S. Mole weight: 393.5. | |
CMI-392 Quick inquiry Where to buy Suppliers range | CMI-392 is a dual antagonist of 5-lipoxygenese (IC50= 100 nM) and platelet-activating factor (PAF) receptor (IC50= 10 nM). Uses: Lipoxygenase inhibitors. Synonyms: 3-[[2-[2-(4-chlorophenyl)sulfanylethoxy]-3-methoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]methyl]-1-hydroxy-1-methylurea; 2-(3-methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N-hydroxyureidyl)methylphenyl)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran; CMI 392; CMI-392. CAS No. 205654-37-1. Molecular formula: C31H37ClN2O8S. Mole weight: 633.15. | |
CMI-977 Quick inquiry Where to buy Suppliers range | CMI-977, an oxolan compound, has been found to be a 5-Lipoxygenases inhibitor and was once studied as an antiasthmatic agent. Synonyms: CMI-977; CMI 977; CMI977; LPD-977; LPD 977; LPD977; MLN-977; MLN977; MLN 977; 1-[4-[(2S,5S)-5-[(4-fluorophenoxy)methyl]oxolan-2-yl]but-3-ynyl]-1-hydroxyurea. Grades: 98%. CAS No. 175212-04-1. Molecular formula: C16H19FN2O4. Mole weight: 322.34. | |
COX/5-LO-IN-1 Quick inquiry Where to buy Suppliers range | A dual inhibitor of cylooxygenase and 5-lipoxygenase. Synonyms: Urea, N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl-2-propyn-1-yl]-N-hydroxy-; 1-[4-[5-[(4-fluorophenyl)methyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxyurea. CAS No. 154355-75-6. Molecular formula: C16H15FN2O2S. Mole weight: 318.37. | |
Curcumin-d6 Quick inquiry Where to buy Suppliers range | Labeled Curcumin. A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope. Group: Biochemicals. Alternative Names: (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione-d6; (E,E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione-d6; C Yellow 15-d6; C.I. 75300-d6; Curcuma-d6; Curcumine-d6; Diferuloylmethane-d6; Haidr-d6; Halad-d6; Haldar-d6; Ukon-d6. Grades: Highly Purified. CAS No. 1246833-26-0. Pack Sizes: 5mg. Molecular Formula: C21H14D6O6, Molecular Weight: 374.42. US Biological Life Sciences. | Worldwide |
Cyanamide Quick inquiry Where to buy Suppliers range | Cyanamide is used in the synthesis of H2 receptor histamine antagonists. Also use in the synthesis of oxadiazoles and 1,2,4-thiaziazoles as dual 5-lipoxygenase and cyclooxygenase inhibitors. Group: Biochemicals. Alternative Names: Alzogur; Amidocyanogen; Carbamonitrile; Carbimide; Cyanamide F 1000; Cyanoamine; Cyanogen nitride; Cyanogenamide; Deurbraak; Dormex; F 1000; Hydrogen cyanamide; N-Cyanoamine; NSC 24133; TsAKS. Grades: Highly Purified. CAS No. 420-04-2. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
Diflapolin Quick inquiry Where to buy Suppliers range | Diflapolin is a dual inhibitor of 5-lipoxygenase-activating protein (FLAP) and soluble epoxide hydrolase (sEH). It is selective for FLAP and sEH over other arachidonic acid metabolism enzymes. Diflapolin (1, 3, and 10 mg/kg) decreases inflammation in a mouse model of peritonitis induced by zymosan, reducing the production of LTB4 and LTC4 and inhibiting leukocyte recruitment. Grades: ≥98%. CAS No. 724453-98-9. Molecular formula: C22H17Cl2N3O2S. Mole weight: 458.36. | |
Di-(tert-Butyl-dimethylsilyl) Curcumin Quick inquiry Where to buy Suppliers range | Protected Curcumin. A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope. Group: Biochemicals. Alternative Names: (1E, 4Z, 6E) -1, 7-Bis[4-[[ (1, 1-dimethylethyl) dimethylsilyl]oxy]-3-methoxyphenyl]-5-hydroxy-1, 4, 6-heptatrien-3-one. Grades: Highly Purified. CAS No. 1134639-23-8. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
Ebselen Quick inquiry Where to buy Suppliers range | Glutathione peroxidase mimetic. Peroxynitrite scavenger. Anti-inflammatory Antioxidant. Protein kinase C (PKC), NADPH, lipoxygenase, COX, NOS, H+-ATPase and NADPH oxidase inhibitor. Antifungal. Group: Biochemicals. Grades: Highly Purified. CAS No. 60940-34-3. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C13H9NOSe. US Biological Life Sciences. | Worldwide |
Edaravone Trimer Quick inquiry Where to buy Suppliers range | Edaravone Trimer is an impurity of Edaravone. Edaravone is a novel potent free radical scavenger that reduces reactive oxygen species, inhibits apoptosis, and blocks nonenzymatic peroxidation and lipoxygenase activity. Synonyms: 5,?5',?5''-trimethyl-2,?2',?2''-triphenyl-[4,?4':4',?4''-Ter-4H-pyrazole]?-3,?3',?3''(2H,?2'H,?2''H)?-trione; 4,4-bis(3-methyl-5-oxo-1-phenyl(2-pyrazolin-4-yl))-3-methyl-1-phenyl-2-pyrazol in-5-one; 2-Phenyl-5-methyl-4,4-bis(2-phenyl-3-oxo-5-methyl-3,4-dihydro-2H-pyrazole-4-yl)-3,4-dihydro-2H-pyrazole-3-one. CAS No. 68195-63-1. Molecular formula: C30H26N6O3. Mole weight: 518.577. | |
Eicosatetraynoic Acid Quick inquiry Where to buy Suppliers range | ETYA is a nonspecific and cell permeable inhibitor of cyclooxygenases and lipoxygenases. ETYA inhibits phospholipase A2 (PLA2), cytochrome P-450, cyclooxygenase, 5-lipoxygenase, 12-lipoxygenase, and 15-lipoxygenase in whole cells. Synonyms: ETYA; 5,8,11,14-eicosatetraynoic acid; Octadehydroarachidonic acid. Grades: ≥98%. CAS No. 1191-85-1. Molecular formula: C20H24O2. Mole weight: 296.4. | |
Enazadrem phosphate Quick inquiry Where to buy Suppliers range | Enazadrem phosphate is a 5-lipoxygenase inhibitor as an Antipsoriatic agent. Uses: Antipsoriatic agent. Synonyms: UNII-93VML10KA9; ENAZADREM PHOSPHATE; Enazadrem phosphate (USAN); Enazadrem phosphate [USAN]; SCHEMBL219332; 93VML10KA9; D03990;4,6-Dimethyl-2-((6-phenylhexyl)amino)-5-pyrimidinol phosphate (1:1) (salt);107361-33-1(base). Grades: 98%. CAS No. 132956-22-0. Molecular formula: C18H28N3O5P. Mole weight: 397.41. | |
EP6 Quick inquiry Where to buy Suppliers range | EP6 is a 5-lipoxygenase (5-LO) inhibitor. Synonyms: EP-6; EP 6. Grades: ≥98% by HPLC. CAS No. 1353567-32-4. Molecular formula: 24H30N4O. Mole weight: 390.5. | |
Etalocib Quick inquiry Where to buy Suppliers range | LY293111, a novel diaryl ether carboxylic acid derivative, is a potent and selective inhibitor of the lipoxygenase pathway either directly through 5'-lipoxygenase or via antagonism of the leukotriene B4 (LTB4) receptor. LY293111 has antineoplastic activity in a variety of preclinical models. Synonyms: LY293111; VML 295; 2-[3-[3-[(5-Ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-2-propylphenoxy]benzoic Acid; 2- [2-Propyl-3- [3- [2-ethyl-4- (4-fluorophenyl) -5-hydroxyphenoxy] propoxy] phenoxy] benzoic acid. Grades: ≥98%. CAS No. 161172-51-6. Molecular formula: C33H33FO6. Mole weight: 544.61. | |
FR 110302 Quick inquiry Where to buy Suppliers range | This active molecular is a potent 5-lipoxygenase inhibitor which was originated by Fujisawa company for treating asthma. No-Development was reported for asthma in Japan. Synonyms: FR 110302; FR110302; FR-110302. 2,2-dibutyl-1,2,3,4-tetrahydro-5-(2-quinolinylmethoxy)-1-Naphthalenol. Grades: 98%. CAS No. 119256-94-9. Molecular formula: C28H35NO2. Mole weight: 417.58. | |
GSK2190915 Quick inquiry Where to buy Suppliers range | GSK2190915 is a potent FLAP(5-Lipoxygenase-activating protein) inhibitor. It exhibits excellent preclinical toxicology and pharmacokinetics in rat and dog. It also demonstrated an extended pharmacodynamic effect in a rodent bronchoalveolar lavage (BAL) model. It increased survival time in mice exposed to a lethal intravenous injection of platelet activating factor (PAF). Synonyms: AM-803; AM 803; AM803; 3Fiboflapon; GSK2190915; GSK 2190915; GSK-2190915. Grades: >98%. CAS No. 936350-00-4. Molecular formula: C38H43N3O4S. Mole weight: 637.83. | |
GSK2190915 sodium salt Quick inquiry Where to buy Suppliers range | GSK2190915(AM-803; Fiboflapon) sodium salt is a potent FLAP(5-Lipoxygenase-activating protein) inhibitor with binding IC50 of 2.9 nM. Synonyms: GSK2190915 sodium salt; GSK 2190915 sodium salt; GSK-2190915 sodium salt; GSK-2190915A; GSK 2190915A; GSK2190915A; Fiboflapon sodium; AM-803 sodium; AM 803 sodium; AM803 sodium. Grades: >98%. CAS No. 1196070-26-4. Molecular formula: C38H42N3NaO4S. Mole weight: 659.81. | |
Heneicosapentaenoic acid Quick inquiry Where to buy Suppliers range | Heneicosapentaenoic acid (HPA) is a 21:5 ω-3 fatty acid found in the green alga B. pennata and in fish oils. HPA is incorporated into phospholipids and into triacylglycerol in cell culture and inhibits the conversion of linolenic acid to arachidonic acid (AA) in hepatoma cells. HPA is a poor substrate for prostaglandin H synthase (PGHS) (cyclooxygenase) and for 5-lipoxygenase. Synonyms: HPA; (all-Z)-6,9,12,15,18-heneicosapentaenoic acid; (6Z,9Z,12Z,15Z,18Z)-6,9,12,15,18-henicosapentaenoic acid. Grades: ≥95%. CAS No. 24257-10-1. Molecular formula: C21H32O2. Mole weight: 316.5. | |
Heneicosapentaenoic acid methyl ester Quick inquiry Where to buy Suppliers range | Heneicosapentaenoic acid methyl ester is a derivative of heneicosapentaenoic acid (HPA), a 21:5 ω-3 fatty acid found in the green alga B. pennata and in fish oils. HPA is incorporated into phospholipids and into triacylglycerol in cell culture and inhibits the conversion of linolenic acid to arachidonic acid (AA) in hepatoma cells. HPA is a poor substrate for prostaglandin H synthase (PGHS) (cyclooxygenase) and for 5-lipoxygenase. Synonyms: HPA methyl ester; Methyl 6,9,12,15,18-heneicosapentaenoate; (all-Z)-6,9,12,15,18-heneicosapentaenoic acid methyl ester; (6Z,9Z,12Z,15Z,18Z)-6,9,12,15,18-henicosapentaenoic acid methyl ester. Grades: ≥98%. CAS No. 65919-53-1. Molecular formula: C22H34O2. Mole weight: 330.5. |