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Lupeol (Clerodol; Monogynol B; Fagarasterol) is an active pentacyclic triterpenoid, has anti-oxidant, anti-mutagenic, anti-tumor and anti-inflammatory activity. Lupeol is a potent androgen receptor (AR) inhibitor and can be used for cancer research, especially prostate cancer of androgen-dependent phenotype (ADPC) and castration resistant phenotype (CRPC) [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Clerodol; Monogynol B; Fagarasterol. CAS No. 545-47-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0790.
Lupeol
Lupeol. Group: Biochemicals. Grades: Highly Purified. CAS No. 545-47-1. Pack Sizes: 10mg, 25mg, 50mg, 100mg. Molecular Formula: C30H50O. US Biological Life Sciences.
Worldwide
Lupeol
Lupeol is a pentacyclic triterpenoid that is lupane in which the hydrogen at the 3beta position is substituted by a hydroxy group. It occurs in the skin of lupin seeds, as well as in the latex of fig trees and of rubber plants. It is also found in many edible fruits and vegetables. It has a role as an anti-inflammatory drug and a plant metabolite. It is a secondary alcohol and a pentacyclic triterpenoid. It derives from a hydride of a lupane. Alternative Names: Fagarasterol. Clerodol. Monogynol B. CAS No. 545-47-1. Product ID: PIPE-0510. Molecular formula: C30H50O. Mole weight: 426.7. EINECS: 208-889-9. SMILES: CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)C. Appearance: White Solid. Category: Natural Extract.
Lupeol
Lupeol is isolated from the flower of Chrysanthemum morifolium. It enhances the radiosensitivity of SMMC-7721 cells in vitro and in vivo. Uses: Anti-inflammatory agents. Synonyms: Fagarasterol; Clerodol; Monogynol B. Grade: 98%. CAS No. 545-47-1. Molecular formula: C30H50O. Mole weight: 426.7.
Lupeol
Lupeol - Product ID: NST-10-174. Category: Triterpens. Alternative Names: Monogynol B, (+)-Lupeol, Clerodol, Fagarasterol, Lupenol, ?-Viscol. Purity: 98%. Test method: HPLC. CAS No. 545-47-1. Pack Sizes: 0,05g, 0,1g, 0,25g, 0,5g. Appearance: White powder. Molecular formula: C30H50O. Mole weight: 426.73. Storage: +2 +8 °C.
Lupeol
Lupeol. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Fagarsterol; Lupenol; B-VISCOL; Cautchicol; monogynolb; Lupeol; MONOGYNOL; Clerodol. Product Category: Steroidal Compounds. Appearance: White powder. CAS No. 545-47-1. Molecular formula: C30H50O. Mole weight: 426.7. Purity: 0.98. IUPACName: (1R,3aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysen-9-ol. Canonical SMILES: CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)C. Density: 0.977 g/cm³. Product ID: ACM545471. Alfa Chemistry ISO 9001:2015 Certified.
Lupeol acetate
Lupeol acetate is a derivative of Lupeol. Lupeol acetate is an anti-inflammatory , antibacterial , anti-trypanosomic and anticancer agent with oral activity. Lupeol acetate significantly improves the symptoms of rheumatoid arthritis by down-regulating the expression of inflammatory cytokines and osteoclast production. Lupeol acetate inhibits spermatogenesis in male rats and eventually led to infertility [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 1617-68-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-126114.
Lupeol Acetate
Lupeol Acetate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-O-acetyl-lupeol; lup-20(29)-en-3-yl acetate; (3beta)-lup-20(29)-en-3-yl acetate; lupeol acetate; 3-acetoxy-28-deoxobetulin; 3-Acetyllupeol; Lupeyl acetate; LUPENYL ACETATE. Product Category: Steroidal Compounds. Appearance: Powder. CAS No. 1617-68-1. Molecular formula: C32H52O2. Mole weight: 468.77. Purity: 0.98. IUPACName: [(1R,3aR,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysen-9-yl] acetate. Canonical SMILES: CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)OC(=O)C)C)C. Density: 1.01g/cm³. Product ID: ACM1617681. Alfa Chemistry ISO 9001:2015 Certified.
Also forms some β-amyrin. The recombinant enzyme from Arabidopsis thaliana gives a 1:1 mixture of lupeol and lupan-3β,20-diol with small amounts of β-amyrin, germanicol, taraxasterol and ψ-taraxasterol. See EC 4.2.1.128 (lupan-3β,20-diol synthase). Group: Enzymes. Synonyms: LUPI; BPW; RcLUS. Enzyme Commission Number: EC 5.4.99.41. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5583; lupeol synthase; EC 5.4.99.41; LUPI; BPW; RcLUS. Cat No: EXWM-5583.
2,2'-Ethylenedianiline
2,2'-Ethylenedianiline is used as a reagent to synthesize Oxcarbazepine (O869250), a broad-specturm, second-generation anticonvulsant drug that is used to treat partial and complex partial seizures in children and adults. 2,2'-Ethylenedianiline is also used as a reagent to prepare a series of triterpines (e.g. Lupeol [L474850]), compounds that have chemopreventative activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 34124-14-6. Pack Sizes: 1g, 5g. Molecular Formula: C14H16N2, Molecular Weight: 212.29. US Biological Life Sciences.
Worldwide
β-amyrin 28-monooxygenase
The enzyme, found in plants, is involved in the biosynthesis of oleanane-type triterpenoids, such as ginsenoside Ro. The enzyme from Medicago trunculata (CYP716A12) can also convert α-amyrin and lupeol to ursolic acid and betulinic acid, respectively. Group: Enzymes. Synonyms: CYP716A52v2; CYP716A12; β-amyrin 28-oxidase. Enzyme Commission Number: EC 1.14.13.201. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0803; β-amyrin 28-monooxygenase; EC 1.14.13.201; CYP716A52v2; CYP716A12; β-amyrin 28-oxidase. Cat No: EXWM-0803.
β-amyrin synthase
Some organism possess a monofunctional β-amyrin synthase, other have a multifunctional enzyme that also catalyses the synthesis of α-amyrin (EC 5.4.99.40) or lupeol (EC 5.4.99.41). Group: Enzymes. Synonyms: 2,3-oxidosqualene β-amyrin cyclase; AsbAS1; BPY; EtAS; GgbAS1; LjAMY1; MtAMY1; PNY; BgbAS. Enzyme Commission Number: EC 5.4.99.39. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5580; β-amyrin synthase; EC 5.4.99.39; 2,3-oxidosqualene β-amyrin cyclase; AsbAS1; BPY; EtAS; GgbAS1; LjAMY1; MtAMY1; PNY; BgbAS. Cat No: EXWM-5580.
The enzyme produces germanicol, β-amyrin and lupeol in the ratio 63:33:4. Group: Enzymes. Synonyms: RsM1; (S)-2,3-epoxysqualene mutase (cyclizing, germanicol-forming). Enzyme Commission Number: EC 5.4.99.34. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5575; germanicol synthase; EC 5.4.99.34; RsM1; (S)-2,3-epoxysqualene mutase (cyclizing, germanicol-forming). Cat No: EXWM-5575.
lupan-3β,20-diol synthase
The reaction occurs in the reverse direction. The recombinant enzyme from Arabidopsis thaliana gives a 1:1 mixture of lupeol and lupan-3β,20-diol with small amounts of β-amyrin, germanicol, taraxasterol and ψ-taraxasterol. See EC 5.4.99.41 (lupeol synthase). Group: Enzymes. Synonyms: LUP1 (gene name). Enzyme Commission Number: EC 4.2.1.128. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4969; lupan-3β,20-diol synthase; EC 4.2.1.128; LUP1 (gene name). Cat No: EXWM-4969.
taraxerol synthase
The enzyme gives taraxerol, β-amyrin and lupeol in the ratio 70:17:13. Group: Enzymes. Synonyms: RsM2; (S)-2,3-epoxysqualene mutase (cyclizing, taraxerol-forming). Enzyme Commission Number: EC 5.4.99.35. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5576; taraxerol synthase; EC 5.4.99.35; RsM2; (S)-2,3-epoxysqualene mutase (cyclizing, taraxerol-forming). Cat No: EXWM-5576.
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