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| Product | Description | |
|---|---|---|
| Lymphocyte activating pentapeptide | Heterocyclic Organic Compound. Alternative Names: LEU-PRO-PRO-SER-ARG;H-LEU-PRO-PRO-SER-ARG-OH;LYMPHOCYTE ACTIVATING PENTAPEPTIDE. CAS No. 120484-65-3. Molecular formula: C25H44N8O7. Mole weight: 568.67. Catalog: ACM120484653. |  |
| Granzyme A Positive Control (GZMA, Granzyme-1, CTL Tryptase, Cytotoxic T-lymphocyte-associated Serine Esterase 3, CTLA3, Cytotoxic T-lymphocyte Proteinase 1, Fragmentin-1, Hanukkah Factor, H Factor, HF, HFSP) | Granzyme A Positive Control (GZMA, Granzyme-1, CTL Tryptase, Cytotoxic T-lymphocyte-associated Serine Esterase 3, CTLA3, Cytotoxic T-lymphocyte Proteinase 1, Fragmentin-1, Hanukkah Factor, H Factor, HF, HFSP). Group: Molecular Biology. US Biological Life Sciences. |  Worldwide |
| 1-(1-iodoethyl)-4-octylbenzene | 1-(1-iodoethyl)-4-octylbenzene is an impurity of Fingloimod, also known as FTY720. FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. FTY720 is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 us reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 15mg, 30mg. Molecular Formula: C16H25I, Molecular Weight: 344.27. US Biological Life Sciences. | Worldwide |
| 1,2,4-Trihydroxybenzene | 1,2,4-Trihydroxybenzene, a by-product of coffee bean roasting, increases intracellular Ca2+ concentration in rat thymic lymphocytes. It is a common intermediate in the biodegradation of many aromatic compounds. Synonyms: 1,2,4-Trihydroxybenzene; 2,5-Dihydroxyphenol; 2-Hydroxy-1,4-hydroquinone; 2-Hydroxy-p-benzohydroquinone; 2-Hydroxyhydroquinone; 4-Hydroxycatechol; HHQ; Hydroxyhydroquinone; NSC 2818. Grades: ≥98%. CAS No. 533-73-3. Molecular formula: C6H6O3. Mole weight: 126.11. |  |
| 1,2,4-Trihydroxybenzene | 1,2,4-Trihydroxybenzene (Hydroxyhydroquinone), a by-product of coffee bean roasting, increases intracellular Ca 2+ concentration in rat thymic lymphocytes [1]. Uses: Scientific research. Group: Natural products. CAS No. 533-73-3. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-W010451. |  |
| 1-?(2-?Iodoethyl)?-?2-?octylbenzene | 1-?(2-?Iodoethyl)?-?2-?octylbenzene is an impurity of Fingloimod (F805000), also known as FTY720. FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. FTY720 is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 us reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively). Group: Biochemicals. Grades: Highly Purified. CAS No. 162358-96-5. Pack Sizes: 1mg, 5mg. Molecular Formula: C16H25I, Molecular Weight: 344.27. US Biological Life Sciences. | Worldwide |
| 12(R)-HETE | 12(R)-HETE is a metabolite of Arachidonic acid, AA (HY-109590) and can be found in skin from psoriatic lesions. 12(R)-HETE induces lymphocytes chemotaxis, stimulates calcium mobilization and chemotaxis in neutrophils via the BLT1 receptor, activates the aryl hydrocarbon receptor, and inhibits Na+/K+ ATPase activity in the corneal epithelium [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 82337-46-0. Pack Sizes: 5 μg (312.04 μM * 50 μL in Ethanol); 10 μg (312.04 μM * 100 μL in Ethanol); 25 μg (312.04 μM * 250 μL in Ethanol); 50 μg (312.04 μM * 500 μL in Ethanol). Product ID: HY-124404. | |
| 1,3-Butadiene (~15% by weight in Toluene) | 1,3-Butadiene has been shown in multiple studies to be carcinogenic and toxic to rats (1,4), strongly suggesting that it has cytotoxic effects on humans as well. 1,3-Butadiene is a component of tobacco smoke, and has also shown to encourage arteriosclerotic plaque accumulation (2) and its epoxides induce sister chromatid exchanges in human lymphocytes (3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants. Group: Biochemicals. Grades: Highly Purified. CAS No. 106-99-0. Pack Sizes: 1g, 10 g. Molecular Formula: C4H6. US Biological Life Sciences. | Worldwide |
| 1-Cyclopropane Mycophenolic Acid | 1-Cyclopropane Mycophenolic Acid is a non-active analogue of Mycophenolic Acid (M831500), an antibiotic produced by Penicillium brevi-compactum, P. Stoloniferum and related spp. A selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of purine nucleotides. Group: Biochemicals. Grades: Highly Purified. CAS No. 125198-40-5. Pack Sizes: 10mg, 100mg. Molecular Formula: C18H22O6. US Biological Life Sciences. | Worldwide |
| 1-Hydroxy-3-nitrodeamino Fingolimod | An impurity of Fingolimod (F805000, HCl salt), a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. Group: Biochemicals. Grades: Highly Purified. CAS No. 899822-99-2. Pack Sizes: 25mg, 250mg. Molecular Formula: C19H31NO5, Molecular Weight: 353.45. US Biological Life Sciences. | Worldwide |
| 1-Hydroxy Fingolimod Hydrochloride | 1-Hydroxy Fingolimod Hydrochloride is an impurity of the drug Fingolimond (F805000, HCl salt) which is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. Group: Biochemicals. Grades: Highly Purified. CAS No. 268557-51-3. Pack Sizes: 1mg, 10mg. Molecular Formula: C19H33NO3 HCl, Molecular Weight: 323.473645999999. US Biological Life Sciences. | Worldwide |
| 1-O-D-Sorbitol Mycophenolate | 1-O-D-Sorbitol Mycophenolate is an impurity or sugar conjugate of Mycophenolic Acid (M831500), which is an antibiotic produced by Penicillium brevi-compactum, P. Stoloniferum and related spp. It is a selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 25mg. Molecular Formula: C23H32O11, Molecular Weight: 484.49. US Biological Life Sciences. | Worldwide |
| 2,2'-((4-Octyl-1,3-phenylene)bis(ethane-2,1-diyl))bis(2-aminopropane-1,3-diol) Dihydrochloride | 2,2'-((4-Octyl-1,3-phenylene)bis(ethane-2,1-diyl))bis(2-aminopropane-1,3-diol) Dihydrochloride is a related compound of the drug Fingolimod hydrochloride (F805000), an immunosuppressive agent that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C24H46Cl2N2O4, Molecular Weight: 497.54. US Biological Life Sciences. | Worldwide |
| 2,2-Dimethyl-5-[2-(4-octylphenyl)ethyl]-1,3-dioxan-5-amine | 2,2-Dimethyl-5-[2-(4-octylphenyl)ethyl]-1,3-dioxan-5-amine is an intermediate in the synthesis of N-[2(4-(-Octylphenyl))butanoic Acid] Fingolimod,which is an impurity of Fingolimod (F805000, HCl salt). Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. Group: Biochemicals. Grades: Highly Purified. CAS No. 1313876-85-5. Pack Sizes: 10mg, 25mg. Molecular Formula: C22H37NO2. US Biological Life Sciences. | Worldwide |
| 2-[4- (1-Hydroxyoctyl) phenyl]ethyl Acetate | 2-[4- (1-Hydroxyoctyl) phenyl]ethyl Acetate is an impurity of Fingolimod (F805000, HCl salt) which is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 25mg. Molecular Formula: C18H28O3, Molecular Weight: 292.41. US Biological Life Sciences. | Worldwide |
| 2-[4-(Oct-1-en-yl)phenyl]ethyl Acetate | 2-[4-(Oct-1-en-yl)phenyl]ethyl Acetate is an impurity of Fingolimod (F805000, HCl salt) which is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 25mg. Molecular Formula: C18H26O2, Molecular Weight: 274.399999999999. US Biological Life Sciences. | Worldwide |
| 2-(4-Octylphenethyl)-fingolimod | 2-(4-Octylphenethyl)-fingolimod is an impurity of the drug Fingolimod hydrochloride (F805000), an immunosuppressive agent that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. Group: Biochemicals. Grades: Highly Purified. CAS No. 851039-25-3. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C35H57NO2, Molecular Weight: 523.83. US Biological Life Sciences. | Worldwide |
| 28-Ethyl-d4-hydroxy Rapamycin | 28-Ethyl-d4-hydroxy Rapamycin is the labeled analogue of 28-Ethylhydroxy Rapamycin (E678640), an impurity of Everolimus (E945400),a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C53H79D4NO14, Molecular Weight: 962.25. US Biological Life Sciences. | Worldwide |
| 28-Ethylhydroxy Everolimus-d4 Impurity | 28-Ethylhydroxy Everolimus-d4 Impurity is a deuterium labelled 28-Ethylhydroxy-everolimus Impurity (E945435). It is also an impurity of Everolimus (E945400), which is a derivative of Rapamycin (R124000). Everolimus inhibits cytokine-mediated lymphocyte proliferation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C55H83D4NO15, Molecular Weight: 1006.3. US Biological Life Sciences. | Worldwide |
| 28-Ethylhydroxy Everolimus Impurity | 28-Ethylhydroxy Everolimus Impurity is an impurity of Everolimus (E945400), which is a derivative of Rapamycin (R124000). Everolimus inhibits cytokine-mediated lymphocyte proliferation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C55H87NO15, Molecular Weight: 1002.28. US Biological Life Sciences. | Worldwide |
| 2-Amino-2-[2- (4-heptylphenyl) ethyl]propane-1, 3-diol | 2-Amino-2-[2- (4-heptylphenyl) ethyl]propane-1, 3-diol is an impurity of Fingolimod (F342045), a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. Group: Biochemicals. Grades: Highly Purified. CAS No. 745767-97-9. Pack Sizes: 1mg, 5mg. Molecular Formula: C18H31NO2, Molecular Weight: 293.44. US Biological Life Sciences. | Worldwide |
| 2-Amino-2-[2-(4-nonylphenyl)ethyl]-1,3-propanediol | 2-Amino-2-[2-(4-nonylphenyl)ethyl]-1,3-propanediol is an impurity of Fingolimod (F342045), a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. Group: Biochemicals. Grades: Highly Purified. CAS No. 746594-44-5. Pack Sizes: 1mg, 5mg. Molecular Formula: C20H35NO2, Molecular Weight: 321.5. US Biological Life Sciences. | Worldwide |
| 2-Dimethylamino Fingolimod | An impurity of Fingolimod (F805000, HCl salt), a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. Group: Biochemicals. Grades: Highly Purified. CAS No. 1404433-87-9. Pack Sizes: 25mg, 250mg. Molecular Formula: C21H37NO2, Molecular Weight: 335.52. US Biological Life Sciences. | Worldwide |
| 2-Fluoro-3- (trifluoromethyl) aniline | 2-Fluoro-3- (trifluoromethyl) aniline is a buliding block for various inhibitors such as 5,6,7-Trimethoxy-N-phenyl(ethyl)-4-aminoquinazoline derivatives that have anticancer activities and N-[3- (Phenylcarbamoyl) aryl]pyrimidine-5-carboxamide that are lymphocyte-specific kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 123973-25-1. Pack Sizes: 5g, 10 g. Molecular Formula: C7H5F4N, Molecular Weight: 179.11. US Biological Life Sciences. | Worldwide |
| 2-Nitrodeamino Fingolimod | An impurity of Fingolimod (F805000, HCl salt), a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. Group: Biochemicals. Grades: Highly Purified. CAS No. 374077-88-0. Pack Sizes: 25mg, 250mg. Molecular Formula: C19H31NO4, Molecular Weight: 337.45. US Biological Life Sciences. | Worldwide |
| 2- ( (tert-Butyldimethylsilyl) oxy) ethyl 2,2,2-trichloroacetimidate | 2- ( (tert-Butyldimethylsilyl) oxy) ethyl 2,2,2-trichloroacetimidate is an intermediate in the synthesis of 28-Ethylhydroxy Rapamycin (E678640), which is an impurity of Everolimus (E945400),a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 250mg, 500mg. Molecular Formula: C10H20Cl3NO2Si. US Biological Life Sciences. | Worldwide |
| 3-(4-Octylphenethyl)-fingolimod | 3-(4-Octylphenethyl)-fingolimod is a related compound of the drug Fingolimod hydrochloride (F805000), an immunosuppressive agent that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. Group: Biochemicals. Grades: Highly Purified. CAS No. 851039-24-2. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C34H56ClNO2, Molecular Weight: 546.27. US Biological Life Sciences. | Worldwide |
| 3-Amino-1-(4-octylphenyl)butane-1,4-diol | 3-Amino-1-(4-octylphenyl)butane-1,4-diol is a related compound of the drug Fingolimod hydrochloride (F805000), an immunosuppressive agent that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 50mg. Molecular Formula: C18H31NO2, Molecular Weight: 293.44. US Biological Life Sciences. | Worldwide |
| 3-Deaza-2'-Deoxyadenosine | It has a strong inhibitory effect on lymphocyte-mediated cytolysis, but has low cytotoxicity at 100 μM. This nucleoside can also be used to evaluate the role of adenine N3 nitrogen in DNA structure and function. Synonyms: 1H-Imidazo[4,5-c]pyridin-4-amine, 1-(2-deoxy-b-D-erythro-pentofuranosyl)-; 3-Deaza-2'-dA; (2R,3S,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol; 4-Amino-2-deoxyribofuranosylimidazo[4,5-c]pyridine; 2'-Deoxy-3-deazaadenosine; 1-(2-Desoxy-β-D-erythro-pentofuranosyl)-1H-imidazo[4,5-c]pyridin-4-amine. Grades: ≥97% by HPLC. CAS No. 78582-17-9. Molecular formula: C11H14N4O3. Mole weight: 250.25. | |
| 3'-?O-?Acetylhamaudol | 3'-O-Acetylhamaudol, isolated from Angelica polymorpha , exhibits anti-tumor activity through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation [1]. Uses: Scientific research. Group: Natural products. CAS No. 30358-88-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N6892. | |
| 4'-Sulphated Lewis X, Methyl Glycoside Sodium Salt | Recently shown to be a good ligand for E- and L-selectins, two calcium-dependent mammalian lectins associated with early steps in the inflammatory response and lymphocyte extravasation into peripheral lymph nodes which makes them good candidates for anti-inflammatory drugs. Synonyms: 4'-SO4-Gal1-b-4[Fuc1-α-3]GlcNAc-b-O-Me, Methyl O-2-α-3-O-(4-sulfo-b-D-galactopyranosyl)-1-b-4-O-[(α-L-fucopyranosyl)-1-α-3]-2-αcetamido-2-deoxy-b-D-glucopyranoside Sodium Salt. Grades: 95%. Molecular formula: C21H36NNaO18S. Mole weight: 645.56. | |
| 5-Carboxyfluorescein diacetate N-succinimidyl ester | 5-Carboxyfluorescein diacetate N-succinimidyl ester is a cell permeable dye (Ex=492 nm, Em=517 nm). 5-Carboxyfluorescein diacetate N-succinimidyl ester can label cells by covalently binding to intracellular molecules. 5-Carboxyfluorescein diacetate N-succinimidyl ester is used to track lymphocyte migration and proliferation [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 150206-05-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-D0056. | |
| 6-Bromobenzo[b]thiophene-2-carbaldehyde | 6-Bromobenzo[b]thiophene-2-carbaldehyde is an aryl-substituted isobenzofuran-1(3H)-one as an inhibitor of the lymphocyte pore-forming protein perforin. Group: Biochemicals. Alternative Names: 6-Bromobenzo[b]thiophene-2-carboxaldehyde. Grades: Highly Purified. CAS No. 19075-45-7. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| 6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) | 6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK), a ShK analog containing a fluorescein-6-carboxyl group attached through an {2-[2-aminoethoxy]ethoxy}acetic acid (AEEAc) linker to the f-amino group of Arg1, selectively blocks the volt-gated T-lymphocyte K+ Kv1.3 channels, which is relevant to the pathogenesis of experimental autoimmune encephalomyelitis. It may be an effective tool for detecting the presence of T-lymphocytes with high expression of Kv1.3 channels in normal and diseased tissues. Synonyms: 6-FAM-AEEAc-ShK; Fluorescein-6-carbonyl-AEEAc-Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys-OH (Disulfide bridge: Cys3-Cys35, Cys12-Cys28, Cys17-Cys32). Grades: ≥95%. CAS No. 1927927-42-1. Molecular formula: C196H295N55O57S7. Mole weight: 4558.22. | |
| 6-Phenanthridone | 6-Phenanthridone is a poly(ADP-ribose) polymerase (PARP) inhibitor with immunosuppressive effects. 6-Phenanthridone has been shown to inhibit concanavalin A-induced lymphocyte proliferation. Group: Biochemicals. Alternative Names: 5H-Phenanthridin-6-one; 6-Phenanthridinol; 6-Phenanthridinone; 6-Phenanthridone; NSC 11021; NSC 40943; NSC 61083; PJ 97A; 6(5H)-Phenanthridinone; WD 99-004344. Grades: Highly Purified. CAS No. 1015-89-0. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 7H-Dibenzo[c,g]carbazole | 7H-Dibenzo[c,g]carbazole (DBC) is an azaarene with high lipophilicity. 7H-Dibenzo[c,g]carbazole has carcinogenic activity and induce DNA adducts in fish, DNA adducts, mutations in diploid human fibroblasts and micronuclei in human blood lymphocytes. 7H-Dibenzo[c,g]carbazole is activated by cytochrome P450 enzymes resulting mainly in the generation of phenolic metabolites [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DBC. CAS No. 194-59-2. Pack Sizes: 5 g; 10 g; 25 g. Product ID: HY-119983. | |
| 9-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-2,6-diaminopurine (FANA-DAP) | FANA-DAP, a nucleotide analogue, exhibits the capability to target selective immune cells; cytotoxic T lymphocytes and natural killer cells, and is effective in enhancing their activity against tumor cells. This unique immunomodulatory drug shows great potential as a therapeutic agent in combating various types of cancer, including melanoma, prostate cancer, and hepatocellular carcinoma. The complex structure and mechanism of FANA-DAP make it a potential candidate for advancing cancer treatment and is a promising area of research for future studies. Grades: ≥ 97%. Molecular formula: C10H15FN6O3. Mole weight: 286.2629. | |
| Adenosine-3',5'-cyclic Monophosphate Sodium Salt (A-3:5-MP, cAMP, Na) | A key regulator of many cellular reactions. Released in response to hormonal stimulation. An activator of protein kinase A. Directly activates Epac, a Rap1 guanine-nucleotide exchange factor. Acts as a second messenger in signal transduction mechanisms. Promotes apoptosis in resting human B lymphocytes. Group: Biochemicals. Grades: Highly Purified. CAS No. 37839-81-9. Pack Sizes: 100mg, 1g. US Biological Life Sciences. | Worldwide |
| Adenosine-3,5-cyclic Monophosphate Sodium Salt (A-3:5-MP, cAMP, Na) | A key regulator of many cellular reactions. Released in response to hormonal stimulation. An activator of protein kinase A. Directly activates Epac, a Rap1 guanine-nucleotide exchange factor. Acts as a second messenger in signal transduction mechanisms. Promotes apoptosis in resting human B lymphocytes. Group: Biochemicals. Grades: Highly Purified. CAS No. 37839-81-9. Pack Sizes: 1g. Molecular Formula: C??H??N?O?P · Na. US Biological Life Sciences. | Worldwide |
| Adjuvant Peptide | Adjuvant Peptide is an immunomodulatory factor that can be used as a vaccine adjuvant to enhance immune response. It inhibits HIV replication in CD4+H9 lymphocytes. Uses: Adjuvants, immunologic. Synonyms: D-α-Glutamine, N-(N-acetylmuramoyl)-L-alanyl-; D-α-Glutamine, N2-[N-(N-acetylmuramoyl)-L-alanyl]-; N-(N-Acetylmuramoyl)-L-alanyl-D-α-glutamine; Acetylmuramoyl-L-alanyl-D-isoglutamine; MDP; MDP-D; Muramoyl dipeptide; N-(Acetylmuramoyl)-L-alanyl-D-isoglutamine; N-(Acetylmuramoyl)alanyl-D-isoglutamine; N-Acetylmuramoyl dipeptide; N-Acetylmuramoyl-L-alanine-D-isoGln; N-Acetylmuramoylalanyl-D-isoglutamine; (4R,5R,7R,10S,13R)-13-carbamoyl-4-formyl-7,10-dimethyl-2,8,11-trioxo-5-((1R,2R)-1,2,3-trihydroxypropyl)-6-oxa-3,9,12-triazahexadecan-16-oic acid; N-Ac-Mur-Ala-D-Glu-NH2; N-Acetylmuramyl-L-Ala-D-Glu-NH2; Muramyl dipeptide. Grades: ≥95%. CAS No. 53678-77-6. Molecular formula: C19H32N4O11. Mole weight: 492.48. | |
| AITRL human | AITRL, a cytokine belonging to the tumor necrosis factor (TNF) ligand superfamily, is expressed in endothelial cells, and signals through the AITR receptor. AITRL regulates T-cell proliferation and survival, and effectuates the interaction between T lymphocytes and endothelial cells. AITRL is a ligand for receptor TNFRSF18/AITR/GITR. GITR/AITRL interaction plays a role in the pathogenesis of tumors, inflammation, and autoimmune diseases. In addition, AITRL is involved in endothelial cell (EC) activation and increases STAT-1 phosphorylation and the expression of adhesion molecules (VCAM-1, ICAM-1). Synonyms: Activation-induced TNFR member Ligand; TNFSF18; rHuActivation-inducible TNF-related Ligand/AITRL; GITRL; TL-6; Tumor necrosis factor ligand superfamily member 18; rHuAITRL; GITR Ligand. Grades: ≥98% by HPLC. Mole weight: ~14.3 kDa. | |
| Alefacept | Alefacept (BG 9273) is a human lymphocyte function-associated antigen 3/immunoglobulin 1 fusion protein. Alefacept can be used for the research of chronic plaque psoriasis [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: BG 9273; Human LFA 3IgG fusion protein; LFA 3TIP. CAS No. 222535-22-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99429. | |
| Alemtuzumab | Alemtuzumab (Campath-IH) is a humanized monoclonal antibody against CD52. Alemtuzumab does not cross-react with murine CD52. Alemtuzumab selectively targets the CD52 antigen to induce profound lymphocyte depletion, followed by recovery of T and B cells with regulatory phenotypes. Alemtuzumab is capable of complement-dependent cytotoxicity and antibody-dependent cell-mediated cytotoxicity (ADCC), as well as induction of apoptosis. Alemtuzumab has the potential for B-cell chronic lymphocytic leukaemia research [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Campath-IH. CAS No. 216503-57-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P9948. | |
| α(1-2,3) Mannosidase from Xanthomonas manihotis, Recombinant | α-Mannosidase is an acid hydrolase which is located in plant vacuoles and is thought to be involved with the turnover of N-linked glycoproteins. α-Mannosidase has been shown to inhibit the proliferation of B-lymphocytes. Α1-2,3 mannosidase is a highly specific exoglycosidase that catalyzes the hydrolysis of α1-2 and α1-3 linked d-mannopyranosyl residues from oligosaccharides. Group: Enzymes. Synonyms: alpha-D-mannosidase; alpha-mannosidase; alpha-D-mannoside mannohydrolase; α-D-Mannosidase; EC 3.2.1.24; 9025-42-7. Mannosidase. Mole weight: 90 kDa. Activity: 80,000 units/mg. Storage: 4°C. Form: 50 mM NaCl, 20 mM Tris-HCl (pH 7.5 25°C) and 1 mM Na2 EDTA. Source: E. coli. Species: Xanthomonas manihotis. alpha-D-mannosidase; alpha-mannosidase; alpha-D-mannoside mannohydrolase; α-D-Mannosidase; EC 3.2.1.24; 9025-42-7; α(1-2,3) Mannosidase. Cat No: NATE-1269. |  |
| α (1-6)-Mannosidase from Xanthomonas manihotis, Recombinant | α-Mannosidase is an acid hydrolase which is located in plant vacuoles and is thought to be involved with the turnover of N-linked glycoproteins. α-Mannosidase has been shown to inhibit the proliferation of B-lymphocytes. α-Mannosidase from Canavalia ensiformis is a tretamer composed of two subunits that each contain two components at 44 and 66 kDa. Group: Enzymes. Synonyms: α-mannosidase; α-D-mannosidase; p-nitrophenyl-α-mannosidase; α-D-mannopyranosidase; 1,2-α-mannosidase; 1,2-α-D-mannosidase; exo-α-mannosidase; EC 3.2.1.24; 9025-42-7; Mannosidase. Enzyme Commission Number: EC 3.2.1.24. CAS No. 9025-42-7. Mannosidase. Source: E. coli. Species: Xanthomonas manihotis. α-mannosidase; α-D-mannosidase; p-nitrophenyl-α-mannosidase; α-D-mannopyranosidase; 1,2-α-mannosidase; 1,2-α-D-mannosidase; exo-α-mannosidase; EC 3.2.1.24; 9025-42-7; Mannosidase. Cat No: NATE-0439. | |
| Alpha-fetoprotein (158-166) | Alpha-fetoprotein (158-166) is a truncated fragment of Alpha-fetoprotein which is often derepressed in human hepatocellular carcinoma. Peptide fragments of AFP presented in the context of major histocompatibility molecules could serve as potential recognition targets by CD8 T cells, provided these lymphocytes were not clonally deleted in ontogeny. Synonyms: AFP (158-166). | |
| Alpha-fetoprotein (364-373) | Alpha-fetoprotein (364-373) is a truncated fragment of Alpha-fetoprotein which is often derepressed in human hepatocellular carcinoma. Peptide fragments of AFP presented in the context of major histocompatibility molecules could serve as potential recognition targets by CD8 T cells, provided these lymphocytes were not clonally deleted in ontogeny. Synonyms: AFP (364-373). | |
| Alpha-fetoprotein (542-550) | Alpha-fetoprotein (542-550) is a truncated fragment of Alpha-fetoprotein which is often derepressed in human hepatocellular carcinoma. Peptide fragments of AFP presented in the context of major histocompatibility molecules could serve as potential recognition targets by CD8 T cells, provided these lymphocytes were not clonally deleted in ontogeny. Synonyms: AFP (542-550). | |
| α-Mannosidase 125A from Clostridium perfringens, Recombinant | α-Mannosidase is an acid hydrolase which is located in plant vacuoles and is thought to be involved with the turnover of N-linked glycoproteins. α-Mannosidase has been shown to inhibit the proliferation of B-lymphocytes. Group: Enzymes. Synonyms: alpha-D-mannosidase; alpha-mannosidase; alpha-D-mannoside mannohydrolase; α-D-Mannosidase; EC 3.2.1.24; 9025-42-7. Enzyme Commission Number: EC 3.2.1-. Purity: >90% by SDS-PAGE. Mannosidase. Mole weight: 51.8 kDa. Storage: This enzyme is shipped at room temperature but should be stored at -20 °C. Form: 35 mM NaHepes buffer, pH 7.5, 750 mM NaCl, 200 mM imidazol, 3.5 mM CaCl2, 0.02% sodium azide and 25% (v/v) glycerol. Source: E. coli. Species: Clostridium perfringens. alpha-D-mannosidase; alpha-mannosidase; alpha-D-mannoside mannohydrolase; α-D-Mannosidase; EC 3.2.1.-; α-Mannosidase 125A. Cat No: NATE-1472. | |
| α-Mannosidase 125A from Streptococcus pneumoniae, Recombinant | α-Mannosidase is an acid hydrolase which is located in plant vacuoles and is thought to be involved with the turnover of N-linked glycoproteins. α-Mannosidase has been shown to inhibit the proliferation of B-lymphocytes. Group: Enzymes. Synonyms: alpha-D-mannosidase; alpha-mannosidase; alpha-D-mannoside mannohydrolase; α-D-Mannosidase; EC 3.2.1.24; 9025-42-7. Enzyme Commission Number: EC 3.2.1-. Purity: >90% by SDS-PAGE. Mannosidase. Mole weight: 51.1 kDa. Storage: This enzyme is shipped at room temperature but should be stored at -20 °C. Form: 35 mM NaHepes buffer, pH 7.5, 750 mM NaCl, 200 mM imidazol, 3.5 mM CaCl2, 0.02% sodium azide and 25% (v/v) glycerol. Source: E. coli. Species: Streptococcus pneumoniae. alpha-D-mannosidase; alpha-mannosidase; alpha-D-mannoside mannohydrolase; α-D-Mannosidase; EC 3.2.1.-; α-Mannosidase 125A. Cat No: NATE-1473. | |
| α-Mannosidase 38A from Streptococcus pyogenes, Recombinant | α-Mannosidase is an acid hydrolase which is located in plant vacuoles and is thought to be involved with the turnover of N-linked glycoproteins. α-Mannosidase has been shown to inhibit the proliferation of B-lymphocytes. Group: Enzymes. Synonyms: alpha-D-mannosidase; alpha-mannosidase; alpha-D-mannoside mannohydrolase; α-D-Mannosidase; EC 3.2.1.24; 9025-42-7. Enzyme Commission Number: EC 3.2.1-. Purity: >50% by SDS-PAGE. Mannosidase. Mole weight: 104 kDa. Storage: This enzyme is shipped at room temperature but should be stored at -20 °C. Form: 35 mM NaHepes buffer, pH 7.5, 750 mM NaCl, 200 mM imidazol, 3.5 mM CaCl2, 0.02% sodium azide and 25% (v/v) glycerol. Source: E. coli. Species: Streptococcus pyogenes. alpha-D-mannosidase; alpha-mannosidase; alpha-D-mannoside mannohydrolase; α-D-Mannosidase; EC 3.2.1.-; α-Mannosidase 38A. Cat No: NATE-1474. | |
| α-Mannosidase 92L from Bacteroides thetaiotaomicron, Recombinant | α-Mannosidase is an acid hydrolase which is located in plant vacuoles and is thought to be involved with the turnover of N-linked glycoproteins. α-Mannosidase has been shown to inhibit the proliferation of B-lymphocytes. Group: Enzymes. Synonyms: alpha-D-mannosidase; alpha-mannosidase; alpha-D-mannoside mannohydrolase; α-D-Mannosidase; EC 3.2.1.24; 9025-42-7. Enzyme Commission Number: EC 3.2.1-. Purity: >90% by SDS-PAGE. Mannosidase. Mole weight: 81.9 kDa. Storage: This enzyme is shipped at room temperature but should be stored at -20 °C. Form: 35 mM NaHepes buffer, pH 7.5, 750 mM NaCl, 200 mM imidazol, 3.5 mM CaCl2, 0.02% sodium azide and 25% (v/v) glycerol. Source: E. coli. Species: Bacteroides thetaiotaomicron. alpha-D-mannosidase; alpha-mannosidase; alpha-D-mannoside mannohydrolase; α-D-Mannosidase; EC 3.2.1.-; α-Mannosidase 92L. Cat No: NATE-1471. | |
| AMG 369 | This active molecular is a S1P1/S1P5 agonist with limited activity at S1P3. AMG 369 has no activity at S1P2 and S1P4. AMG-369 is shown to reduce blood lymphocyte counts 24 hours postdose with dosed orally at 0.1 mg/kg. Till Jun 2016, no recent reports of development identified for preclinical development in Multiple-sclerosis in USA were published yet. Uses: Multiple sclerosis. Synonyms: AMG-369; AMG 369; AMG369; KB-74649; KB74649; KB 74649. 1-[[3-fluoro-4-[6-(1-phenylcyclopropyl)-[1,3]thiazolo[5,4-b]pyridin-2-yl]phenyl]methyl]azetidine-3-carboxylicacid; ZINC216149127;1202073-26-4. Grades: 98%. CAS No. 1202073-26-4. Molecular formula: C26H22FN3O2S. Mole weight: 459.54. | |
| Anomalin A | Lck (p56lck; lymphocyte specific tyrosine kinase) inhibitor. Antioxidant. DPPH radical scavenger. Group: Biochemicals. Alternative Names: 2,3,6,8-Tetrahydroxy-1-methylxanthone. Grades: Highly Purified. CAS No. 548740-86-9. Pack Sizes: 1mg. Molecular Formula: C14H10O6. US Biological Life Sciences. | Worldwide |
| Anomalin A (2,3,6,8-Tetrahydroxy-1-methylxanthone) | Originally isolated from the marine fungus Arthrinium sp., Anomalin A is a potent Lck (p56lck; lymphocyte specific tyrosine kinase) inhibitor. Also acts as an antioxidant and DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenger. Group: Biochemicals. Grades: Highly Purified. CAS No. 548740-86-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Antibiotic 2-11-A | It is produced by the strain of Streptomyces sp. 2-11. It can inhibit the proliferation of splenic lymphocytes induced by Concanavalin A in mice. Synonyms: Gibbestatin A; Benzoic acid, 2-hydroxy-6-[5-(1-methoxyethyl)-7-[(3-methyloxiranyl)methylene]-6-oxo-1,3-nonadienyl]-; 2-11-A. CAS No. 89687-35-4. Molecular formula: C23H28O6. Mole weight: 400.46. | |
| APHE-3 | APHE-3 is a pyrazoloisoquinolinone antibiotic produced by Streptoverticillium griseocarneum. It has weak anti-Gram-positive bacteria activity. APHE-3 can also inhibit lymphocyte proliferation in the presence of Phytohemagglutinin, with IC50 of about 0.1 mmol/L. Synonyms: Pimprinine; WS 30581C. Grades: >95% by HPLC. CAS No. 13640-26-1. Molecular formula: C12H10N2O. Mole weight: 198.22. | |
| AR-C155858 | AR-C155858 is a novel inhibitor of the monocarboxylate transporters (MCTs) MCT1 and MCT2, but exhibits no activity at MCT4. It can be used to probe MCTs' roles in the metabolic studies. Besides, AR-C155858 was found to have immunosuppressive activity and can inhibit the proliferation of T-lymphocytes. Synonyms: ARC155858; AR-C155858; ARC 155858. Grades: >98%. CAS No. 496791-37-8. Molecular formula: C21H27N5O5S. Mole weight: 461.53. | |
| Argyrin B | Argyrin B can strongly inhibit the murine mixed lymphocyte reaction (MLR) and is an inhibitor of antibody formation independent of T cells. Molecular formula: C41H46N10O8S. Mole weight: 838.93. | |
| Arvanil | Arvanil is a vanilloid TRPV1 (VR1) and cannabinoid CB1 agonist with Ki values of 0.3 and 0.5 μM respectively. It increases lung tidal volume, diaphragm activity, mean arterial blood pressure and inhibits lymphocyte proliferation. It also inhibits the anandamide transporter. It has analgesic, vasodilatory and anti-inflammatory effects in vivo. It is a structural analog of capsaicin. It induces analgesia in rat and mouse models of pain. It is resistant to hydrolysis by FAAH. It is a potent inhibitor of anandamide accumulation. It inhibits growth of astrocytoma xenograft tumors in mice. It mimics the effect of neural precursor cells and has been shown to kill TRPV1-expressing tumor cells by secreting endovanilloids. Synonyms: RT-011322; B-6699; I14-44667; RT011322; B6699; I1444667; N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5Z,8Z,11Z,14Z-eicosatetraenamide; (5Z,8Z,11Z,14Z)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5,8,11,14-Eicosatetraenamide; N-Vanillylarachidonamide; (all-Z)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5,8,11,14-eicosatetraenamide. Grades: ≥98% by HPLC. CAS No. 128007-31-8. Molecular formula: C28H41NO3. Mole weight: 439.64. | |
| AS 602801 | AS 602801 is a novel, orally active inhibitor of JNK. It blocked T-lymphocyte proliferation and induced apoptosis. Synonyms: AS602801; AS-602801; AS 602801; PGL5001; PGL-5001; PGL 5001; Bentamapimod. Grades: >98%. CAS No. 848344-36-5. Molecular formula: C25H23N5O2S. Mole weight: 457.55. | |
| Ascomycin (High Purity) (Immunomycin, FK520, Analog of FK-506, FR-900520, L-683590, NSC 106410, WS 7238A) | Macrolide antibiotic. Ethyl analog of FK506. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin (protein phosphatase 2B (PP2B)). Suppresses the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in T lymphocytes and preferentially inhibits the activation of mast cells. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions. Antifungal. Antimalaria compound. Anticonvulsant (antiepileptic). Group: Biochemicals. Grades: Highly Purified. CAS No. 104987-12-4. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| Aspartyl-alanyl-diketopiperazine acetate | Aspartyl-alanyl-diketopiperazine acetate is an immunomodulatory molecule generated by cleavage and cyclization from the N-terminus of human albumin and can modulate the inflammatory immune response through a molecular pathway implicated in T-lymphocyte anergy. Synonyms: DA-DKP acetate. Molecular formula: C9H14N2O6. Mole weight: 246.22. | |
| Atacicept | Atacicept (TACI-Ig) is a is a recombinant fusion protein containing the extracellular, ligand-binding portion of the TACI receptor and the Fc portion of human IgG. Atacicept inhibits B cell stimulation by binding to B lymphocyte stimulator and a proliferation-inducing ligand. Atacicept can be used in research of B-cell autoimmune disease [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: TACI-Ig; TACI-Fc 5. CAS No. 845264-92-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99446. | |
| AUNP-12 | AUNP-12 (NP-12) is a peptide antagonist of the PD-1 signaling pathway , displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. AUNP-12 exhibits immune activation, excellent antitumor activity, and potential for better management of immune-related adverse events (irAEs) [1]. Uses: Scientific research. Group: Peptides. Alternative Names: NP-12. CAS No. 1353563-85-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1812. | |
| azido-FTY720 | Fingolimod (FTY720) is an FDA approved immunomodulatory drug for treating multiple sclerosis that inhibits lymphocyte egress from lymphoid tissues by down-regulating sphingosine-1 phosphate receptor (S1PR). Phosphorylation of FTY270 by sphingosine kinase can cause S1P1R internalization, which sequesters lymphocytes in lymph nodes, preventing them from taking part in an autoimmune response. It is a first-in-class orally bioavailable compound that has shown efficacy in advanced clinical trials for the treatment of multiple sclerosis (MS). Synonyms: azido-FTY720; 881914-35-8; 2-Amino-2-[2-(3-azido-4-octylphenyl)ethyl]-1,3-propanediol; 2-amino-2-[2-(3-azido-4-octylphenyl)ethyl]propane-1,3-diol; 1,3-Propanediol, 2-amino-2-[2-(3-azido-4-octylphenyl)ethyl]-; AKOS040755896; HY-134976; CS-0168486. Grades: ≥98%. CAS No. 881914-35-8. Molecular formula: C19H32N4O2. Mole weight: 348.5. | |
| BE 14106 | BE 14106 is produced by the strain of Streptomyces sp. It has weak anti-Pseudomonas aeruginosa activity and inhibition of mixed lymphocyte reaction (MLR) activity. Synonyms: BE-14106; GT-32A; 9,10-Dihydroxy-7,15-dimethyl-20-(2-hexenyl)azacycloeicosa-3,5,7,11,13,15,17-heptaen-2-one. CAS No. 140212-86-8. Molecular formula: C27H37NO3. Mole weight: 423.59. | |
| Beauvericin | Beauvericin is a cyclohexapeptide Fusarium toxin with insecticidal, antibacterial, anticancer, antiviral and cytotoxic activities. Beauvericin causes cellular genotoxicity by producing DNA breaks, chromosomal aberrations and micronuclei, and inhibits the PI3K/AKT pathway to induce apoptosis , thereby inhibiting the growth of HCC. In addition, Beauvericin affects immune function by inhibiting lymphocyte proliferation and interfering with the differentiation process of human monocytes into macrophages [1] [2] [3] [4] [5] [6] [7] [8] [9]. Uses: Scientific research. Group: Natural products. CAS No. 26048-05-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N6739. | |
| Belimumab | Belimumab (LymphoStat B) is a humanized IgG1λ monoclonal antibody against B-lymphocyte stimulator ( BLyS ) protein. Belimumab antagonizes BLyS activity in autoimmune diseases and B-lymphocyte malignancies. Belimumab can be used for systemic lupus erythematosus (SLE) research [1] [2] [3] [4]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: LymphoStat B. CAS No. 356547-88-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P9952. | |
| Bestatin | Bestatin is "pseudo"-dipeptide isolated from Streptomyces olivreticuli in 1976. Bestatin is potent aminopeptidase B inhibitor with no carboxypeptidase activity. Bestatin acts as an immunomodulator by activation of macrophages and T-lymphocytes. Bestatin also exhibits good antitumor activity and is under clinical investigation. Group: Biochemicals. Grades: Highly Purified. CAS No. 58970-76-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
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