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| Product | Description | |
|---|---|---|
| 293 Cell Lysate, Flag-transfected | 293 cells transfected with a Flag-tagged minigene, 60kD. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. |  Worldwide |
| 293 Cell Lysate, Human Insulin Treated | Positive control (insulin treated 293 cells) for I7661-18M, Insulin-Like Growth Factor I Receptor, phosphorylated (Tyr1316). Group: Biologicals. Grades: Lysate. Pack Sizes: 200ul. US Biological Life Sciences. | Worldwide |
| A431+ Calyculin A (30min) Lysate | Calyculin A is a serine/threonine phosphatase inhibitor that inhibits the activity of protein phosphatases PP1 and PP2A. Human carcinoma A431 cells treated with calyculin A for 30 minutes can undergo significant threonine phosphorylation, as shown by western blotting using anti-Phospho-Akt (Thr-34), as compared to untreated, control cell lysates. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| A431 Calyculin A Control Lysate | Calyculin A is a serine/threonine phosphatase inhibitor that inhibits the activity of protein phosphatases PP1 and PP2A. Human carcinoma A431 cells treated with calyculin A for 30 minutes can undergo significant threonine phosphorylation, as shown by western blotting using anti-Phospho-Akt (Thr-34), as compared to untreated, control cell lysates. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| A431+ EGF (5min) Lysate | A431 cells express approximately 10e6 epidermal growth factor (EGF) receptors at the cell surface. Upon stimulation with EGF, A431 cells exhibit a dramatic increase in phosphorylation of EGF receptors followed by activation of major cell signaling pathways, such as PKB/Akt and MAP kinase pathways. Downstream of these cell signaling pathways, a variety of cytoskeletal, cytoplasmic, and nuclear proteins become phosphorylated at different time points after EGF stimulation. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| A431 EGF Control Lysate | A431 cells express approximately 10e6 epidermal growth factor (EGF) receptors at the cell surface. Upon stimulation with EGF, A431 cells exhibit a dramatic increase in phosphorylation of EGF receptors followed by activation of major cell signaling pathways, such as PKB/Akt and MAP. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| A431 Pervanadate Control Lysate | Pervanadate is a protein tyrosine phosphatase inhibitor that is commonly used to increase tyrosine phosphorylation in cells. When cells are treated with pervanadate for 30 minutes they undergo significant tyrosine phosphorylation, as shown by Western blotting using anti-Phosphotyrosine. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| A431+ Pervanadate Lysate | Pervanadate is a protein tyrosine phosphatase inhibitor that is commonly used to increase tyrosine phosphorylation in cells. When cells are treated with pervanadate for 30 minutes they undergo significant tyrosine phosphorylation, as shown by western blotting using anti-Phosphotyrosine. Confluent cultures of A431 cells were serum starved overnight. Cells were then either left untreated or treated with pervanadate (1 mM) for 30 minutes at 37°C Cells were lysed in 1% SDS, 1.0mM sodium ortho-vanadate, 10mM Tris (pH 7.4) buffer. Protein concentration was determined using the BCA method (Pierce) before diluting to final concentration and buffer. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| A549 Lysate | A549 cells are adenocarcinomic human alveolar basal epithelial cells. The A549 cell line was initiated from the removal and culturing of cancerous lung tissue in the explanted tumor from 58-year-old male, in 1972. A549 cells is able to synthesize lecithin and contain high level of unsaturated fatty acids, which are important to maintain the membrane phospholipids in cells. A549 cell line are widely used as an in vitro model for a type II pulmonary epithelial cell model for drug metabolism and as a transfection host. Western Blot. Group: Biologicals. Pack Sizes: 100ug, 200ug. US Biological Life Sciences. | Worldwide |
| HeLa Cell Lysate, Heat Shocked | HeLa Cell Lysate (Heat Shocked) is useful in immunoblotting applications as a positive control for many antibodies, particularly those recognizing proteins induced by heat shock. The cells are grown, heat shocked for 2 hours at 44°C, and allowed to recover at 37°C for 5 to18 hours before harvest. The cells are then washed, lysed, sonicated, and resuspended in SDS-PAGE sample buffer. Group: Biologicals. Grades: Lysate. Pack Sizes: 200ug. US Biological Life Sciences. | Worldwide |
| HE Pervanadate Control Lysate | Pervanadate is a protein tyrosine phosphatase inhibitor that is commonly used to increase tyrosine phosphorylation in cells. Human aortic endothelial cells treated with pervanadate for 30 minutes display a significant increase in tyrosine phosphorylation as shown by western. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| HE+ Pervanadate Lysate | Pervanadate is a protein tyrosine phosphatase inhibitor that is commonly used to increase tyrosine phosphorylation in cells. Human aortic endothelial cells treated with pervanadate for 30 minutes display a significant increase in tyrosine phosphorylation as shown by western. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| HepG2 Cell Lysate, Untreated | HepG2 Cell Lysate, Untreated. Group: Biologicals. Grades: Lysate. Pack Sizes: 1Ea. US Biological Life Sciences. | Worldwide |
| HepG2 Cell Lysate, Vanadate Treated | HepG2 Cell Lysate, Vanadate Treated. Group: Biologicals. Grades: Lysate. Pack Sizes: 1Ea. US Biological Life Sciences. | Worldwide |
| Jurkat Cell Lysate | Cellular Protein Preparation: Group: Biologicals. Grades: Lysate. Pack Sizes: 100ul. US Biological Life Sciences. | Worldwide |
| Jurkat Pervanadate Control Lysate | Pervanadate is a protein tyrosine phosphatase inhibitor that is commonly used to increase tyrosine phosphorylation in cells. When cells are treated with pervanadate for 30 minutes they undergo significant tyrosine phosphorylation, as shown by western blotting using anti-Phosphotyrosine. Confluent cultures of Jurkat cells were serum starved overnight. Cells were then either left untreated or treated with pervanadate (1 mM) for 30 minutes at 37°C. Cells were lysed in 1% SDS, 1.0mM sodium ortho-vanadate, 10mM Tris (pH 7.4) buffer. Protein concentration was determined using the BCA method (Pierce) before diluting to final concentration and buffer. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Jurkat+ Pervanadate Lysate | Pervanadate is a protein tyrosine phosphatase inhibitor that is commonly used to increase tyrosine phosphorylation in cells. When cells are treated with pervanadate for 30 minutes they undergo significant tyrosine phosphorylation, as shown by western blotting using anti-Phosphotyrosine. Confluent cultures of Jurkat cells were serum starved overnight. Cells were then either left untreated or treated with pervanadate (1 mM) for 30 minutes at 37°C. Cells were lysed in 1% SDS, 1.0mM sodium ortho-vanadate, 10mM Tris (pH 7.4) buffer. Protein concentration was determined using the BCA method (Pierce) before diluting to final concentration and buffer. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Multiple Tag Fusion Protein, Positive Control (Cell Lysate) | Multiple Tag Cell Lysate is whole E. coli cell lysate containing about 30% of a specially designed fusion protein as a positive control for Western blot or Dot blot. The fusion protein is a 40kD protein containing 16 commonly used tags in the order as shown in the table: Group: Biologicals. Grades: Lysate. Pack Sizes: 200ug. US Biological Life Sciences. | Worldwide |
| PC-3 Cell Lysate (Human Prostate Adenocarcinoma) | Cell Lysate Preparation: Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| SW480 Cell Lysate, LiCl-treated | Western Blot positive control cell lysate for C2069-48D. Cell lysate from SW480 cells. Serum starved cells were treated for 15min with LiCl. Group: Biologicals. Grades: Lysate. Pack Sizes: 200ul. US Biological Life Sciences. | Worldwide |
| Tissue, Lysate, Rat Brain, Neonatal | Lysate Preparation: Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Universal Protein Lysate, Canine Adult Normal | Universal Protein Lysates: Group: Biologicals. Grades: Molecular Biology Grade. Pack Sizes: 2x500ug, 4x500ug. US Biological Life Sciences. | Worldwide |
| Universal Protein Lysate, Chicken Adult Normal | Universal Protein Lysates: Group: Biologicals. Grades: Molecular Biology Grade. Pack Sizes: 2x500ug, 4x500ug. US Biological Life Sciences. | Worldwide |
| Universal Protein Lysate, Human Adult Normal | Universal Protein Lysates: Group: Biologicals. Grades: Molecular Biology Grade. Pack Sizes: 2x500ug, 4x500ug. US Biological Life Sciences. | Worldwide |
| Universal Protein Lysate, Monkey Adult Normal | Universal Protein Lysates: Group: Biologicals. Grades: Molecular Biology Grade. Pack Sizes: 2x500ug, 4x500ug. US Biological Life Sciences. | Worldwide |
| Universal Protein Lysate, Mouse Adult Normal | Universal Protein Lysates: Group: Biologicals. Grades: Molecular Biology Grade. Pack Sizes: 2x500ug, 4x500ug. US Biological Life Sciences. | Worldwide |
| Universal Protein Lysate, Rat Adult Normal | Universal Protein Lysates: Group: Biologicals. Grades: Molecular Biology Grade. Pack Sizes: 2x500ug, 4x500ug. US Biological Life Sciences. | Worldwide |
| A431 Cells, EGF-Stimulated | Cellular protein preparation from A431 cells containing phosphorylated proteins, including the EGF receptor. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ul. US Biological Life Sciences. | Worldwide |
| A431 Cells, Non-Stimulated in RIPA Buffer, Sample Buffer | Cellular protein preparation from human A431 cells. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Activating Transcription Factor 2, Control Cell Extracts (ATF2) | Total cell extracts from NIH/3T3 cells prepared without treatment, suitable for use as a negative control. Group: Biologicals. Grades: Lysate. Pack Sizes: 10Blots. US Biological Life Sciences. | Worldwide |
| Akt Control Cell Extracts (Rac PKa, PKBa) | Akt Control Cell Extracts (Rac PKa, PKBa). Group: Biologicals. Grades: Lysate. Pack Sizes: 10Blots. US Biological Life Sciences. | Worldwide |
| Animal Tissue PCR Kit | Animal Tissue PCR Kit. Animal tissue pcr kit uses a unique lysis buffer to lyse animal tissues (fresh or frozen) and blood. the resulting lysate without purification can be directly used as pcr template. pcr product can be directly used for gel electrophoresis. Group: Cloning Enzymes. Purity: 100×; 500×. Storage: Store at -20 ?. Cat No: CE-3011. |  |
| Arietin | The source of Arietin is Cicer arietinum. It has antifungal activity against B.cinerea, F.oxysporum and M.arachidicola. Arietin also inhibits cell-free translation in rabbit reticulocyte lysate system. And it does not have mitogenic and anti-HIV-1 reverse transcriptase activities. |  |
| ARN 14686 | ARN14686 is a NAAA (N-acylethanolamine acid amidase) activity-based protein profiling (ABPP) probe. ARN14686 can be used to detect NAAA by using click chemistry in cell lysates or intact cells, which binds covalently to the N-terminal cysteine of catalytically active NAAA to form a thioester adduct. ARN14686 inhibits the hydrolysis of the NAAA substrate PAMCA in HEK293 cells. The IC50s for human is 6 and the IC50s for rat recombinant enzymes is 13 nM. Synonyms: (S)-Undec-10-yn-1-yl (2-oxoazetidin-3-yl)carbamate. Grades: ≥98% by HPLC. CAS No. 1628345-10-7. Molecular formula: C15H24N2O3. Mole weight: 280.36. | |
| Atto 590 nhs ester | ATTO 590 is a novel fluorescent label belonging to the class of Rhodamine dyes. The dye is designed for application in the area of life science, e.g. labeling of DNA, RNA or proteins. The ATTO dyes are a series of fluorescent dyes that provide all the crucial properties required for modern fluorescent technologies, such as fluorescence microscopy, flow-cytometry, fluorescence in situ hybridization (FISH), receptor binding assays or enzyme assays. The dye is highly suitable for single-molecule detection applications and high-resolution microscopy. The NHS-esters are used in common conjugation protocols.ATTO 590 is a novel fluorescent label belonging to the class of Rhodamine dyes, which has an absorption maximum of 594 nm and an emission maximum of 624 nm. ATTO 590-N-hydroxysuccinimide (NHS) is membrane permeable. Uses: Molar absorption 120,000 1/m cm, abs: 593 nm, em: 620 nm, qy=0.93, tfl 4.0 ns (unpublished data)atto 590 nhs ester may be suitable for use in site-specific labeling of human embryonic kidney (hek293t) cell lysates for western blotting, fluorescence, and widefield microscopy studies. Synonyms: 2-(6, 20-diethyl-7, 7, 9, 17, 19, 19-hexamethyl-2-oxa-20-aza-6-azoniapentacyclo[12.8.0.03, 12.05, 10.016, 21; docosa-1(14),3,5,8,10,12,15,17,21-nonaen-13-yl)-4-(2,5-dioxopyrrolidin-1-yl)oxycarbonylbenzoic acid;perchlorate; 6-(2-Carboxy-5-{[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl}phenyl)-1,11-diethyl-2,2,4,8,10,10-hexamethyl-10,11-dihydro-2H-pyrano[3,2-g:5,6-g']diquinolin-1-ium perchlorate. Grades: ≥60% (coupling to amines). CAS No. 670269-33-7. Molecular formula: C41H42ClN3O11. Mole weight: 788.24. | |
| C2C12 Nuclear Extract, Differentiated (Muscle, Myoblast) | Permanent murine cell lines of fast and slow skeletal myocyte derivation. Group: Biologicals. Grades: Lysate. Pack Sizes: 200ug. US Biological Life Sciences. | Worldwide |
| C2C12 Nuclear Extract, Undifferentiated (Muscle, Myoblast) | Permanent murine cell lines of fast and slow skeletal myocyte derivation. Group: Biologicals. Grades: Lysate. Pack Sizes: 200ug. US Biological Life Sciences. | Worldwide |
| Cancer Hydrolase KIAA1363 Inhibitor, JW480 (2-Isopropylphenyl-2- (2-naphthyl) ethylcarbamate, AADACL1 Inhibitor, Arylacetamide Deacetylase-Like 1 Inhibitor, NCEH1 Inhibitor, Neutral Cholesterol Ester Hydrolase 1 Inhibitor) | A membrane-permeable, highly potent and selective inhibitor against the 2-acetyl MAGE (monoakylglycerol ether) hydrolase KIAA1363/AADACL1 of both human (IC50=12nM; PC3 lysate) and murine (IC50=20nM; brain membrane samples) origin, with no significant effect toward other PC3 or murine brain serine hydrolase activities, including HSL, FAAH, and AChE. Readily crosses blood-brain barrier in mice and effectively suppresses PC3-derived tumor growth in mice in vivo (by 56% on day 33; 80mg/kg/day; o.g.). Also inhibits blood carboxylesterase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Cicerin | Cicerin is isolated from Cicer arietinum. It has antifungal activity against B.cinerea, F.oxysporum and M.arachidicola. Cicerin also inhibits cell-free translation in rabbit reticulocyte lysate system. Synonyms: cicerin; (3R,3S)-onogenin; CHEMBL1088034; CHEBI:174460; DTXSID901129133; 5,7-Dihydroxy-2'-methoxy-4',5'-methylenedioxyisoflavanone; 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-3-(6-methoxy-1,3-benzodioxol-5-yl)-; 5,7-dihydroxy-3-(6-methoxy-1,3-benzodioxol-5-yl)-2,3-dihydrochromen-4-one; 5,7-dihydroxy-3-(6-methoxy-2H-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-1-benzopyran-4-one; 12751-00-7. CAS No. 12751-00-7. Molecular formula: C17H14O7. Mole weight: 330.29. | |
| c-Jun Control Cell Extracts | C-Jun is a component of the transcription factor AP-1 that binds and activates transcription at TRE/AP-1 elements. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73 (1,2). Extracellular signals including growth factors, transforming oncoproteins and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun dependent transcription. Mutation of Ser63/73 renders c-Jun nonresponsive to mitogenic and stress induced signaling pathways. The MAP kinase homologue, SAPK/JNK, binds to the N-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73. In addition, the activity of SAPK/JNK is stimulated by the same signals that activate c-Jun (3,4). Nonphosphorylated c-Jun (Ser63) II Cell Extracts: Total cell extracts from NIH/3T3 cells, prepared without treatment, serve as a negative control. Group: Biologicals. Grades: Lysate. Pack Sizes: 10Blots. US Biological Life Sciences. | Worldwide |
| CREB Control Cell Extracts (cAMP Response Element Binding Protein) | CREB Control Cell Extracts (cAMP Response Element Binding Protein). Group: Biologicals. Grades: Lysate. Pack Sizes: 10Blots. US Biological Life Sciences. | Worldwide |
| Epiblastin A | Epiblastin A is a Casein Kinase 1 (CK1) inhibitor. Epiblastin A engages CK1 isoenzymes in cell lysate and induces efficient conversion of epiblast stem cells (EpiSCs) into embryonic stem cells (cESCs). Uses: Designed for use in research and industrial production. Additional or Alternative Names: Epiblastin A; AUE. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 16470-02-3. Molecular formula: C12H10ClN7. Mole weight: 287.71. Purity: >98%. IUPACName: 6-(3-Chloro-phenyl)-pteridine-2,4,7-triamine. Canonical SMILES: NC1=NC(N)=C2N=C(C3=CC=CC(Cl)=C3)C(N)=NC2=N1. Product ID: ACM16470023. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Epithelial Cell Extract | Contains the following antigenic components from human whole cell extract as tested by western blot: SS-A (Ro) with 60 kD and 52 kD bands, SS-B (La) with 50 kD band (note that the SS-A 52 kD and the SS-B 50 kD bands overlap due to their size), Scl-70 (topoisomerase I) with 105 kD band, RNP with 68 kD and 33 kD bands, Smith with 26 kD and 25 kD bands, Jo-1 with 53 kD band, and Ribosomal P with 38 kD band. Group: Biologicals. Grades: Lysate. Pack Sizes: 1ml. US Biological Life Sciences. | Worldwide |
| Fibroblast Cell, 3T3/A31 | Cellular protein preparation from murine 3T3 fibroblasts. Group: Biologicals. Grades: Lysate. Pack Sizes: 50ul, 100ul. US Biological Life Sciences. | Worldwide |
| Fibroblast Cell, 3T3 L1 Adipocytes, Control Extract, LIF- | Fibroblast Cell, 3T3 L1 Adipocytes, Control Extract, LIF-. Group: Molecular Biology. Grades: Lysate. Pack Sizes: 80ul. US Biological Life Sciences. | Worldwide |
| FIN56 | FIN56 is a specific inducer of ferroptosis and causes the loss of GPX4 activity in cell lysates. Synonyms: FIN56; FIN-56; FIN 56. 2-N,7-N-dicyclohexyl-9-hydroxyiminofluorene-2,7-disulfonamide; s8254. CAS No. 1083162-61-1. Molecular formula: C25H31N3O5S2. Mole weight: 517.66. | |
| GF-109203X | GF-109203X is a potent and highly selective PCK inhibitor, which inhibits PKC isozymes alpha, beta 1, beta 2, gamma, delta and epsilon in vitro. GF-109203X inhibited GSK-3 in vitro, when assayed either in cell lysates (IC(50) 360 nM or in GSK-3beta immunoprecipitates (IC(50) 170 nM derived from rat epididymal adipocytes. Pretreatment of adipocytes with GF-109203X (5 microM) reduced GSK-3 activity in total cell lysates, to 25.1+/-4.3% of control. Synonyms: GF109203X; GF 109203X; Bisindolylmaleimide i; GO 6850; GO-6850; GO6850; 2-[1-(3-dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl)maleimide. Grades: ≥98%. CAS No. 133052-90-1. Molecular formula: C25H24N4O2. Mole weight: 412.49. | |
| HeLa Nuclear Extract | Nuclear extract is prepared from human HeLa cells using a modified protocol of Dignam et al., which contains a variety of DNA-binding proteins and transcription factors. Group: Biologicals. Grades: Lysate. Pack Sizes: 50ug. US Biological Life Sciences. | Worldwide |
| IkB alpha Control Cell Extracts | The NF-kB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IkB proteins (1-3). Activation occurs via phosphorylation of IkB-a at Ser32 and Ser36, resulting in the release and nuclear translocation of active NF-kB (3-7). IkB-a phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals, including inflammatory cytokines, growth factors and chemokines. Phosphorylation of IkB-a at Ser32 and Ser36 has been shown to stimulate conjugation with ubiquitin followed by proteasome-mediated degradation of IkB, resulting in the release of active NF-kB. Kinases that phosphorylate IkB at these activating sites have been identified (8). Because phosphorylation of IkB-a at Ser32 is essential for release of active NF-kB, phosphorylation at this site is an excellent marker of NF-kB activation (1-3). Nonphosphorylated IkB-a Control Cell Extracts: Total cell extracts from HeLa cells prepared without treatment serve as a negative control. Group: Biologicals. Grades: Lysate. Pack Sizes: 200ul. US Biological Life Sciences. | Worldwide |
| Insulin Receptor (IR), Positive Control | Positive control for I7661-22H Insulin Receptor. Group: Molecular Biology. Grades: Lysate. Pack Sizes: 200ul. US Biological Life Sciences. | Worldwide |
| Insulin Receptor, phosphorylated (Tyr1150/1151) (IR), Positive Control | Positive control for I7661-22T Insulin Receptor, phosphorylated (Tyr1150/1151). Group: Molecular Biology. Grades: Lysate. Pack Sizes: 200ul. US Biological Life Sciences. | Worldwide |
| MAP Kinase Kinase 3,6 (MKK3,6) Control Cell Extracts | MAP Kinase Kinase 3,6 (MKK3,6) Control Cell Extracts. Group: Biologicals. Grades: Lysate. Pack Sizes: 10Blots. US Biological Life Sciences. | Worldwide |
| MAP Kinase p38, Control Cell Extracts (Mitogen Activated Protein Kinase p38, MAPK p38) | P38 MAP kinase (MAPK), also called RK (3) or CSBP (2), is the mammalian homologue of the yeast HOG kinase and participates in a signaling cascade controlling cellular responses to cytokines and stress (1-4). Four isoforms of p38 MAP kinase, alpha, beta, gamma and delta, have been identified so far. Like the SAPK/JNK pathway, p38 MAP kinase is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides (LPS), UV light and growth factors (1-5). MKK3 and SEK activate p38 MAP kinase by phosphorylation at threonine 180 and tyrosine 182. Activated p38 MAP kinase has been shown to phosphorylate and activate MAPKAP kinase 2 (3) and to phosphorylate the transcription factors ATF-2 (5), Max (6) and MEF2 (5-8). Nonphosphorylated p38 MAP Kinase Control Cell. Group: Biologicals. Alternative Names: EC=2.7.11.24. Grades: Lysate. Pack Sizes: 10Blots. US Biological Life Sciences. | Worldwide |
| MJN228 | MJN228 is a selective ligand for the lipid-binding protein nucleobindin 1 (NUCB1) that blocks probe binding to NUCB1. It prevents AEA-DA probe labeling of NUCB1 with an IC50 value of 3.3 μM in HEK293T cell lysates. Synonyms: (4-methylpiperazin-1-yl)-(5-nitro-3-phenyl-1H-indol-2-yl)methanone. Grades: ≥98%. CAS No. 459168-97-9. Molecular formula: C20H20N4O3. Mole weight: 364.4. | |
| Phosphotyrosine Control, EGF-Stimulated A431 Cell | Phosphotyrosine Control, EGF-Stimulated A431 Cell. Group: Biologicals. Grades: Lysate. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Plant Tissue PCR Kit | Plant Tissue PCR Kit. Plant tissue pcr kit uses a unique lysis buffer to lyse plant tissues (fresh or frozen). the resulting lysate without purification can be directly used as pcr template. pcr product can be directly used for gel electrophoresis. dna fragment up to 2 kb and can be used for plants with moderate contents of polysaccharides or polyphenols. Group: Cloning Enzymes. Purity: 100×; 500×. Storage: Store at -20 ?. Cat No: CE-3014. | |
| PME-1 Inhibitor, AMZ-30 | A cell-permeable sulfonyl acrylonitrile compound that acts as a potent and irreversible inhibitor of protein phosphatase methylesterase-1 (PME-1; IC50=600nM and 2.5uM in human cell lysates and in HEK 293T cells, (respectively) with 100-fold greater selectivity over other serine hydrolases; does not function as a general thiol-reactive probe. Shown to lower demethylated PP2A levels by ~80% at 20uM with elevated methylated PP2A (protein phosphatase 2A) form in PME-1 overexpressing HEK 293T cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??FN?O?S?, Molecular Weight: 462.6. US Biological Life Sciences. | Worldwide |
| PMSF | PMSF is an irreversible serine/cysteine protease inhibitor commonly used in the preparation of cell lysates. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Phenylmethylsulfonyl fluoride; Benzylsulfonyl fluoride. CAS No. 329-98-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0496. |  |
| SAPK1, JNK (Stress Activated Protein Kinase, Jun Kinase) Control Cell Extracts | The SAPK/JNK pathway is homologous to the MAPK pathway in its overall form but is activated by largely distinct stimuli (1). A variety of extracellular stimuli activate the JNK/SAPK pathway including inflammatory cytokines, UV light, inhibitors of protein synthesis and osmotic stress (1-5). Inflammatory cytokines such as TNFa and IL1 appear to activate this pathway via the Rac/Rho family of small GTP binding proteins, whereas inhibitors of protein synthesis and UV light appear to act independently of Rho and Rac (6). Activated MEKK1 phosphorylates SEK1 (also known as MKK4), which in turn activates SAPK (also known as JNK). SAPK binds tightly to the N-terminal region of c-Jun and ATF-2. It phosphorylates c-Jun at Ser63 and Ser73, and ATF-2 at Thr69 and Thr71 (5). Group: Biologicals. Grades: Lysate. Pack Sizes: 10Blots. US Biological Life Sciences. | Worldwide |
| Spleen Extract, Bovine | Activities include Ro (SS-A), La (SS-B), Sm, and RNP. Group: Biologicals. Grades: Lysate. Pack Sizes: 1ml. US Biological Life Sciences. | Worldwide |
| Squarunkin A hydrochloride | Squarunkin A is an inhibitor of UNC119 chaperone protein-cargo interaction. It inhibits the binding of a myristoylated peptide representing the N-terminus of Src kinase to UNC119A with an IC50 value of 10?nm. It binds to UNC119 proteins in cell lysate and interferes with the activation of Src kinase. Synonyms: Ethyl 4-((3,4-dioxo-2-((2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)amino)cyclobut-1-en-1-yl)amino)piperidine-1-carboxylate hydrochloride. Grades: ≥98% by HPLC. CAS No. 2253744-55-5. Molecular formula: C25H32F3N5O4·HCl. Mole weight: 560.01. | |
| STAT3 Control Cell Extracts (Signal Transducer and Activator of Transcription 3, Acute-phase Response Factor, APRF) | Stat3 is a key signaling molecule for many cytokines and growth-factor receptors and is required for murine fetal development. Additionally, Stat3 is constitutively activated in a number of human tumors and possesses oncogenic potential and anti-apoptotic activities. Stat3 is activated by tyrosine phosphorylation at Tyr705, which induces dimerization, nuclear translocation and DNA binding. Transcriptional activation seems to be regulated by serine phosphorylation at Ser727, apparently via the MAPK or mTOR pathways. Stat3 isoform expression appears to reflect biological function: the relative expression levels of Stat3alpha (86kD) and Stat3beta (79kD) depend on cell type, ligand exposure or maturation stage of the cells. It is notable that Stat3beta lacks the serine phosphorylation site within the C-terminal transcriptional activation domain. Group: Biologicals. Grades: Lysate. Pack Sizes: 10Blots. US Biological Life Sciences. | Worldwide |
| THP-1 Nuclear Extract (Human Monocyte) | Permanent murine cell lines of fast and slow skeletal myocyte derivation. Group: Biologicals. Grades: Lysate. Pack Sizes: 200ug. US Biological Life Sciences. | Worldwide |
| THP-1 Nuclear Extract, PMA stimulated (Human Monocyte) | Permanent murine cell lines of fast and slow skeletal myocyte derivation. Group: Biologicals. Grades: Lysate. Pack Sizes: 200ug. US Biological Life Sciences. | Worldwide |
| Tissue, Membrane Protein, Human Adult Normal, Adipose HisTek | Tissue Protein Lysate produced under consistent processing conditions to ensure intact structure and original nature. Total protein is prepared from whole-tissue homogenates and presents a consistent pattern on SDS-PAGE analysis. Group: Biologicals. Grades: Molecular Biology Grade. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Tissue, Membrane Protein, Human Adult Normal, Adrenal HisTek | Tissue Protein Lysate produced under consistent processing conditions to ensure intact structure and original nature. Total protein is prepared from whole-tissue homogenates and presents a consistent pattern on SDS-PAGE analysis. Group: Biologicals. Grades: Molecular Biology Grade. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Tissue, Membrane Protein, Human Adult Normal, Bladder HisTek | Tissue Protein Lysate produced under consistent processing conditions to ensure intact structure and original nature. Total protein is prepared from whole-tissue homogenates and presents a consistent pattern on SDS-PAGE analysis. Group: Biologicals. Grades: Molecular Biology Grade. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Tissue, Membrane Protein, Human Adult Normal, Blood Vessel, Artery HisTek | Tissue Protein Lysate produced under consistent processing conditions to ensure intact structure and original nature. Total protein is prepared from whole-tissue homogenates and presents a consistent pattern on SDS-PAGE analysis. Group: Biologicals. Grades: Molecular Biology Grade. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Tissue, Membrane Protein, Human Adult Normal, Brain, Amygdala HisTek | Tissue Protein Lysate produced under consistent processing conditions to ensure intact structure and original nature. Total protein is prepared from whole-tissue homogenates and presents a consistent pattern on SDS-PAGE analysis. Group: Biologicals. Grades: Molecular Biology Grade. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Tissue, Membrane Protein, Human Adult Normal, Brain, Cerebellum (left) HisTek | Tissue Protein Lysate produced under consistent processing conditions to ensure intact structure and original nature. Total protein is prepared from whole-tissue homogenates and presents a consistent pattern on SDS-PAGE analysis. Group: Biologicals. Grades: Molecular Biology Grade. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
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