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| Product | Description | |
|---|---|---|
| 20-Hydroxyecdysone | A member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. More potent than ecdysone. Induces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of high expression) to form in polytene chromosomes. Plays a key role in insect development, cell proliferaton, growth and apoptosis by controlling gene expression involved in moulting and metamorphosis. It acts through a heterodimeric receptor comprising the ecdysone receptor and the ultraspiracle proteins (USP). Regulates lipolysis in insects. Appears in many plants mostly as a protection agent (toxins or antifeedants) against herbivorous insects. Used for controlled gene expression in scientific research, agriculture and medicine. Used for the development of selective insect growth regulators for use as environmentally benign insecticides. Shows biological effects on mammalian species. Neurosteroid. Antiepileptic. Acts on the modulatory site of the GABAA receptor and potentia Group: Biochemicals. Grades: Highly Purified. CAS No. 5289-74-7. Pack Sizes: 5mg, 10mg, 50mg. Molecular Formula: C27H44O7. US Biological Life Sciences. |  Worldwide |
| 6-(Dimethylamino)purine | 6-(Dimethylamino) purine (6-Dimethylaminopurine) is a serine threonine protein kinase inhibitor. 6-(Dimethylamino) purine can inhibit prolactin induced expression of lactoprotein genes in rabbit mammary gland cells. 6-(Dimethylamino) purine can affect the maturation of mammalian oocytes. 6-(Dimethylamino) purine can lead to downregulation of genes related to cell proliferation and cell cycle progression, such as proliferating cell nuclear antigen , insulin-like gene 1 , and serine protease inhibitor 2 genes , and induce apoptosis in lymphoma cells ( apoptosis ) [1] [3] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: 6-Dimethylaminopurine; 6-DMAP. CAS No. 938-55-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg. Product ID: HY-W010128. |  |
| Abl Kinase Mutant active human, Recombinant | Abelson murine leukemia viral oncogene homolog 1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene (previous symbol ABL) located on chromosome 9. c-Abl is sometimes used to refer to the version of the gene found within the mammalian genome, while v-Abl refers to the viral gene. Human abelson murine leukemia viral oncogene homolog 1 (abl-1) (genbank accession no. nm_007313), amino acids 248-531 with t334i mutation and n-terminal his-tag, mw = 33 kda, expressed in a baculovirus-infected sf9 cell expression system. Group: Enzymes. Synonyms: ABL1; JTK7; c-ABL; p150; Abl Kinase; ABL; bcr/abl; c-ABL1; v-abl. Abl Kinase. Mole weight: mol wt 33 kDa. Stability: -70°C. Form: aqueous solution. Source: Baculovirus infected Sf9 cells. Species: Human. ABL1; JTK7; c-ABL; p150; Abl Kinase; ABL; bcr/abl; c-ABL1; v-abl. Cat No: NATE-0013. |  |
| AdipoRon (2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide) | Orally-active adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 at low um concentration. Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells. Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1alpha) which boosts mitochondrial proliferation and energy metabolism. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms. Rescued the shortened lifespan of db/db mice (AdipoRs KO) on high-fat diet. Reduces expression levels of genes encoding inflammatory cytokines such as TNF-alpha, IL-6 and CCL-2 in WAT of WT mice but not db/db mice. Group: Biochemicals. Grades: Highly Purified. CAS No. 924416-43-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| AMPK Signaling Agonist, F17 (4-hydroxy-1-isobutyl-N-(5-methylthiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide) | A cell-permeable 4-hydroxy-2-oxo quinoline carboxamide that acts as an agonist of AMPK signaling. It is shown to reduce fat storage in C. elegans (EC50 ~0.1uM) and reduce the expression level of fat-7 (a C. elegans ortholog of mammalian stearoyl-CoA desaturase-1), through aak-1 (an ortholog for the AMPK-a1 catalytic subunit) and K08F8.2 (a transcription factor) dependent mechanisms. In addition, it markedly reduces the number of lipid droplets in HepG2 human hepatocarcinoma cells at 25uM, and elicits the phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC, the enzyme that catalyzes the rate-limiting step in de novo fatty acid synthesis). F17-induced ACC phosphorylation can be abrogated by simultaneous treatment with an AMPK inhibitor compound C. Group: Biochemicals. Grades: Highly Purified. CAS No. 280112-24-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| AZD-8055 | AZD-8055 is an inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor AZD8055 inhibits the serine/threonine kinase activity of mTOR, resulting in decreased expression of mRNAs necessary for cell cycle progression, which may induce cell cycle arrest and tumor cell apoptosis. Synonyms: AZD8055; AZD-8055; AZD 8055. Grades: 0.98. CAS No. 1009298-09-2. Molecular formula: C25H31N5O4. Mole weight: 465.554. |  |
| Ceramide 3 | C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in the stratum corneum of Saccharomyces cerevisiae, wheat grain, and mammalian epidermis. Cer(t18:0/18:0) consists of a phytosphingosine backbone amine linked to a C18 fatty acid chain. Cer(t18:0/18:0) has the function of regulating apoptosis, cell differentiation, proliferation of smooth muscle cells and inhibition of mitochondrial respiratory chain. It also suppresses the expression of allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated mouse skin tissue. Formulations containing cer(t18:0/18:0) have been used as skin protectants in cosmetics as they reduce water loss and prevent epidermal dehydration and irritation. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: N-Stearoyl phytosphingosine. CAS No. 34354-88-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-141582. | |
| (-)-Cryptopleurine | ( - )-Cryptopleurine is an alkaloid that has been found in Lauraceae and has diverse biological activities. It inhibits the growth of human A375 melanoma, A431 epidermoid carcinoma, A549 lung, MES-SA uterine sarcoma, and MCF-7 breast cancer cells ( IC 50 =3 nM for all).2 ( - )-Cryptopleurine inhibits hypoxia-induced gene expression in a hypoxia response element (HRE) reporter assay ( IC 50 =8.7 nM).3 ( - )-Cryptopleurine (500 μg/mL) prevents lesion formation in tobacco (N. tabacum) plants infected with tobacco mosaic virus (TMV). It also inhibits protein synthesis by yeast and mammalian ribosomes. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (R)-Cryptopleurine; NSC 19912. CAS No. 482-22-4. Pack Sizes: 1 mg. Product ID: HY-121255. | |
| Dihydrofolate Reductase from human, Recombinant | Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry. In humans, the DHFR enzyme is encoded by the DHFR gene. It is found in the q11?q22 region of chromosome 5. Bacterial species possesses distinct DHFR enzymes (based on their pattern of binding diaminoheterocyclic molecules), but mammalian DHFRs are highly similar. Human dhfr is an 186 amino acid protein with an apparent molecular weight of 25 kda. it is 30% homologous to the e. coli protein and up to 70% homologous to vertebrate protein... from mycobacterium smegmatis. human dihydrofolate reductase has been used in a study to investigate the stable expression of green fluorescent protein and the targeted disruption of thioredoxin peroxidase-1 gene in babesia bovis. human dihydrofolate reductase has also been used in a study to investigate the structural analysis of human dihydrofolate reductase as a binary complex. Group: Enzymes. Synonyms: DHFR; dihydrofolate reductase; DYR; DHFRP1; Tetrahydrofolate NADP+ oxidoreductase; EC 1.5.1.3; tetrahydrofolate dehydrogenase; pteridine reductase:dihydrofolate reductase; dihydrofolate reductase:thymidylate synthase; thymidylate synthetase-dihydrofolate reductase; f | |
| Fresolimumab | Fresolimumab (GC1008) is a human monoclonal antibody against TGF-β that neutralizes all mammalian active subtypes of TGF-&beta. The binding affinity of Fresolimumab to TGF-β2 is 1.8 nM. Fresolimumab radiolabeled with 89 Zr can be used for PET analysis of TGF-β expression, antibody uptake and organ distribution. Fresolimumab can be used in the study of cancer, osteogenesis imperfecta, fibrosis and kidney disease [1] [2] [3]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: GC1008. CAS No. 948564-73-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99020. | |
| Gentamycin (Gentamicin) Sulfate Solution 10mg/ml | Broad spectrum, cell culture antibiotic that is non toxic to viruses and mammalian cells at antibacterial levels. Inhibits growth of gram positive and negative bacteria, and mycoplasma. Inhibits normal protein synthesis by binding to L6 protein of 50S ribosomal subunit. Useful antibiotic for Baculovirus expression systems since mutations in rplF prevent Gentamycin from binding. Group: Biochemicals. Grades: Cell Culture Grade. CAS No. 1405-41-0. Pack Sizes: 20ml, 5x20ml, 10x20ml. Molecular Formula: C21H43N5O7 H2SO4, Molecular Weight: ~575.6. US Biological Life Sciences. | Worldwide |
| Gentamycin (Gentamicin) Sulfate Solution 50mg/ml | Broad spectrum, cell culture antibiotic that is non toxic to viruses and mammalian cells at antibacterial levels. Inhibits growth of gram positive and negative bacteria, and mycoplasma. Inhibits normal protein synthesis by binding to L6 protein of 50S ribosomal subunit. Useful antibiotic for Baculovirus expression systems since mutations in rplF prevent Gentamycin from binding. Group: Biochemicals. Alternative Names: Alcomici; Bristagen; Cidomycin; Duragentam; Garamycin; Garasol; Apogen, Gentiomycin C, Refobacin, NSC-82261; Gentamycin sulphate. Grades: Molecular Biology Grade. CAS No. 1405-41-0. Pack Sizes: 20ml, 5x20ml, 10x20ml. US Biological Life Sciences. | Worldwide |
| Gentamycin (Gentamicin) Sulfate USP | Broad spectrum, cell culture aminoglycoside antibiotic that is non toxic to viruses and mammalian cells at antibacterial levels. Inhibits growth of gram positive and negative bacteria, and mycoplasma. Inhibits normal protein synthesis by binding to L6 protein of 50S ribosomal subunit. Useful antibiotic for Baculovirus expression systems since mutations in rplF prevent Gentamycin from binding.Causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site. Antibacterial against Gram-negative aerobic bacteria, Gram-positive bacteria and mycoplasmas. Used as a selection agent (gentamicin-resi...ption of the membrane. This increases the permeability of the cell envelope, leakage of cell contents, and leading to apoptosis and proteolysis (cell death). Causes also cell death by generation of free radicals, phospholipidosis, extracellular calcium-sensing recep- tor stimulation and energetic catastrophe. Source:Micromonospora sp. Group: Biochemicals. Alternative Names: Alcomici; Bristagen; Cidomycin; Duragentam; Garamycin; Garasol; Apogen, Gentiomycin C, Refobacin, NSC-82261; Gentamycin sulphate. Grades: Cell Culture Grade. CAS No. 1405-41-0. Pack Sizes: 5g, 25g, 100g, 500g, 1Kg. Molecular Formula: C21H43N5O7.H2SO4, Molecular Weight: ~575.6. US Biological Life Sciences. | Worldwide |
| Muristerone A | Muristerone A, a phytoecdysteroid analog of ecdysone, acts as an inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals. It is an agonist of the ecdysteroid receptor (Kd = 1 nM), a nuclear receptor that heterodimerizes with a retinoid X receptor ortholog and regulates arthropod development. Muristerone A stimulates Bcl-XL mRNA transcription and inhibits TRAIL- and hFasL-induced apoptosis in RKO cells. Synonyms: (2β, 3β, 5β, 11α, 22R)-2, 3, 5, 11, 14, 20, 22-Heptahydroxycholest-7-en-6-one; Mur A. Grades: ≥97% by HPLC. CAS No. 38778-30-2. Molecular formula: C27H44O8. Mole weight: 496.63. | |
| Muristerone A | Muristerone A is a potent member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. An analog of ecdysone with similar properties to Ponasterone A. Inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals.Induces apoptosis in cells transfected with wild-type Bax. Induces expression of beta-galactosidase. Stimulates Bcl-XL mRNA transcription and inhibits TRAIL- and hFasL-induced apoptosis in RKO cells. Insect steroid hormone involved in regulating metamorphosis, causing a response to G2 cell cycle arrest. Major molting hormone in some insects. Has protective effects in plants.Source:Ipomoea hederacea seeds. Group: Biochemicals. Alternative Names: 2beta, 3beta, 5beta, 11alpha, 14alpha, 20R, 22R-Heptahydroxycholest-7-en-6-one. Grades: Highly Purified. CAS No. 38778-30-2. Pack Sizes: 250ug, 1mg. Molecular Formula: C27H44O8, Method for Determining. US Biological Life Sciences. | Worldwide |
| PLA2G12A from Human, Recombinant | Human PLA2G12A (GenBank Accession No. NM_030821), amino acids 23-189 (end) with C-terminal His-tag, MW=22 kDa, expressed in a mammalian cell expression system. Human pla2g12a (genbank accession no. nm_030821), amino acids 23-189 (end) with c-terminal his-tag, mw=22 kda, expressed in a mammalian cell expression system. Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Group: Enzymes. Synonyms: PLA2G12A; phospholipase A2; GXII; Phospholipase A2 G12; ROSSY; PLA2G12. Purity: > 80% (SDS-PAGE). PLA2. Mole weight: mol wt 22 kDa. Storage: -20°C. Form: aqueous solution; Fomulated in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 200 mM Imidazole, and 20% Glycerol. Source: Mammalian cells. Species: Human. PLA2G12A; phospholipase A2; GXII; Phospholipase A2 G12; ROSSY; PLA2G12. Cat No: NATE-0589. | |
| PLA2G12B from Human, Recombinant | Human PLA2G12B (GenBank Accession No. NM_032562), amino acids 20-295 (end) with C-terminal His tag, MW=21.1 kDa, expressed in a mammalian cell expression system. Human pla2g12b (genbank accession no. nm_032562), amino acids 20-295 (end) with c-terminal his tag, mw=21.1 kda, expressed in a mammalian cell expression system. Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Group: Enzymes. Synonyms: PLA2G12B; phospholipase A2; FKSG71; GXIIB; Phospholipase A2 G12. Purity: > 60% (SDS-PAGE). PLA2. Mole weight: mol wt 21.1 kDa. Storage: -70°C. Form: aqueous solution; Fomulated in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 200 mM Imidazole, and 20% Glycerol. Source: Mammalian cells. Species: Human. PLA2G12B; phospholipase A2; FKSG71; GXIIB; Phospholipase A2 G12. Cat No: NATE-0590. | |
| Trichostatin A (TSA) (Histone Deacetylase Inhibitor)89/1/20 | Trichostatin A is an antifungal antibiotic that is a reversible, potent and specific inhibitor of mammalian histone deacetylase (HDAC) both in vivo and in vitro. Histone deacetylase inhibition causes chromatin relaxation and gene expression modulation. May induce apoptosis. TSA inhibits the eukaryotic cell cycle and induces morphological reversion of transformed cells. It blocks cell cycle progression at G1 phase in Hela Cells. TSA causes accumulation of highly acetylated histones in vivo, while inhibiting the activity of partially purified histone deacetylase in vitro. Group: Biochemicals. Alternative Names: 4,6-Dimethyl-7-[p-dimethylaminophenyl]- 7-oxohepta-2, 4-dienohydroxamic acid). Grades: Highly Purified. CAS No. 58880-19-6. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Tubacin | Tubacin (Tubulin acetylation inducer) is a highly potent, selective, reversible, and cell-permeable inhibitor of histone deacetylase 6 (HDAC6, IC50=4nm). Displays 1000-fold more selectivity for HDAC6 over other HDACs. It inhibits a-tubulin deacetylation in mammalian cells. Unlike trichostatin A (TSA), which is a broad spectrum HDAC inhibitor, tubacin is specific for the tubulin deacetylase activity of HDAC6. Tubacin causes increased acetylation of a-tubulin, accumulation of polyubiquitinated proteins, and apoptosis. It does not affect global histone deacetylation, gene-expression profiling, or cell cycle progression mediated a-tubulin deacetylation in mammalian cells. Group: Biochemicals. Alternative Names: (N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl- 2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3- dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide). Grades: Highly Purified. CAS No. 537049-40-4. Pack Sizes: 500ug, 1mg, 2.5mg. Molecular Formula: C??H??N?O?S, Molecular Weight: 721.86. US Biological Life Sciences. | Worldwide |
| WYE 687 Dihydrochloride (Potent and Selective mTOR Inhibitor, N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyr idinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyr imidin-6-yl]phenyl]-carbamic acid methyl ester hydrochloride) | Potent, ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) (IC50 = 7nm). Displays selectivity for mTOR over PI 3-Kalpha (~100-fold) and PI 3-Kgamma (~500-fold). Inhibits phosphorylation of mTORC1 and mTORC2 substrates including S6K, SGK and Akt; blocks VEGF secretion and HIF-1alpha expression. Exhibits antiproliferative effects in cancer cell lines through G1 cell cycle arrest and selective apoptosis. Group: Biochemicals. Grades: Highly Purified. CAS No. 1062161-90-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 1,8-cineole 2-exo-monooxygenase | A heme-thiolate protein (P-450). The mammalian enzyme, expressed in liver microsomes, performs a variety of oxidation reactions of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. cf. EC 1.14.13.97 (taurochenodeoxycholate 6-hydroxylase), EC 1.14.13.67 (quinine 3-monooxygenase) and EC 1.14.13.32 (albendazole monooxygenase). Group: Enzymes. Synonyms: CYP3A4. Enzyme Commission Number: EC 1.14.13.157. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0757; 1,8-cineole 2-exo-monooxygenase; EC 1.14.13.157; CYP3A4. Cat No: EXWM-0757. | |
| AMN082 | AMN082, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 potently inhibits cAMP accumulation and stimulates GTPγS binding ( EC 50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 97075-46-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103565. | |
| AMN082 free base | AMN082 free base, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 free base potently inhibits cAMP accumulation and stimulates GTPγS binding ( EC 50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 free base shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 83027-13-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103565A. | |
| b-Glucuronidase Inhibitor (1-((6,8-Dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(4-ethoxyphenyl)-1-(2-hydroxyethyl)thiourea) | An orally bioavailable trisubstituted thiourea compound that acts as a potent, uncompetitive and reversible inhibitor of bacterial b-glucuronidase activity (IC50 = 283nM; kcat/Km=0.0987s-1uM-1; Ki4nM in vitro assays against E. coli b-glucuronidase; EC50.7nM in b-glucuronidase expressing HB101 cells) with excellent selectivity over mammalian b-glucuronidases. Shown to directly target the 17-residue (360-376) loop structure that protects the active site of E. coli b-glucuronidase and alter its conformation. Displays negligible cytotoxicity toward both bacterial and mammalian epithelial cells (>100uM for HCT116, Caco-2 and CMT93 colon cancer cells) and offers protection against CPT-11 (50mg/kg, i.p., s.i.d. for 9 days)-induced toxicity in mice (10ug, p.o., b.i.d). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| cathepsin K | Prominently expressed in mammalian osteoclasts, and believed to play a role in bone resorption. In peptidase family C1 (papain family). Group: Enzymes. Synonyms: cathepsin O and cathepsin X (both misleading, having been used for other enzymes); cathepsin O2. Enzyme Commission Number: EC 3.4.22.38. CAS No. 94716-09-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4213; cathepsin K; EC 3.4.22.38; 94716-09-3; cathepsin O and cathepsin X (both misleading, having been used for other enzymes); cathepsin O2. Cat No: EXWM-4213. | |
| CC-115 | CC-115 is a dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR), with potential antineoplastic activity. CC-115 binds to and inhibits the activity of DNA-PK and both raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2), which may lead to a reduction in cellular proliferation of cancer cells expressing DNA-PK and TOR. DNA-PK, a serine/threonine kinase and a member of the PI3K-related kinase subfamily of protein kinases, is activated upon DNA damage and plays a key role in repairing double-stranded DNA breaks via the DNA nonhomologous end joining (NHEJ) pathway. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CC115 ; CC-115; CC 115. Product Category: Inhibitors. Appearance: Red solid powder. CAS No. 1228013-15-7. Molecular formula: C16H16N8O. Mole weight: 336.14. Purity: >98%. IUPACName: 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one. Canonical SMILES: O=C1CNC2=NC=C(C3=CC=C(C4=NC=NN4)N=C3C)N=C2N1CC. Product ID: ACM1228013157. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Genistein | Cell-permeable, reversible, substrate competitive tyrosine kinase inhibitor (including EGFR phosphorylation), implicated in almost all cell growth and proliferation signal cascades. Inhibitor of mammalian DNA topoisomerase II. Anticancer agent, inducing cell cycle arrest and apoptosis. Antiangiogenic agent, down-regulates the transcription of genes involved in controlling angiogenesis. Binds estrogen receptor beta. Can increase the rate of growth of some ER expressing breast cancers. Potent alpha-glucosidase inhibitor. Anthelmintic. Anti-diabetic. Activates nuclear receptors, oestrogen receptors and peroxisome proliferator-activated receptors (all PPAR isoforms) and it inhibits various enzyme activities. Inhibitor of GLUT4-mediated glucose uptake in 3T3-L1 adipocytes. Stimulator of autophagy vacuolization. Antioxidant. TRAIL sensitizer. Acts as an agonist at the GPR30 receptor. DNA methyltransferase inhibitor. Genistein exhibits synergistic antibacterial effects on MRSA. Group: Biochemicals. Alternative Names: NSC 36586; Baichanin A; Differenol A; 4',5,7-Trihydroxyisoflavone; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. Grades: Highly Purified. CAS No. 446-72-0. Pack Sizes: 10mg, 50mg, 250mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
| Native Bovine Protein Phosphatase 2C | Protein Phosphatase 2C is a Mg2+-dependent serine/threonine protein phosphatase with a molecular mass of 42-45 kDa, involved in regulating numerous cellular processes. It is ubiquitously expressed and has been isolated from many mammalian tissues including liver, brain, skeletal muscle, retina, and blood platelets. There are two major isotypes associated with this enzyme, 2C1 and 2C2, also known as 2Ca and 2Cb, respectively. Both isozymes appear to be equally Mg2+-dependent and respond similarly to specific substrates. Both are monomers that demonstrate ~75% sequence homology. The molecular masses are similar; 44 kDa and 42 kDa for 2C1 and 2C2, respectively. Additional Type 2C serine/threonine protein phosphatases include 2Cg, 2Cd, Wip1, and NERPP2C, many of which have multiple isozyme members. Group: Enzymes. Synonyms: Protein Phosphatase 2C; PP2C. Protein Phosphatase. Activity: ~1000 units/mg protein. Stability: -70°C. Form: buffered aqueous glycerol solution. Source: Bovine kidney. Species: Bovine. Protein Phosphatase 2C; PP2C. Pack: vial of 1 μg. Cat No: NATE-0619. | |
| pancreatic elastase II | A peptidase of family S1 (trypsin family) formed by activation of proelastase II from mammalian pancreas by trypsin. Usually, only one of the pancreatic elastases (see also EC 3.4.21.36) is expressed in a given species; human pancreatic elastase is of type II. Group: Enzymes. Synonyms: pancreatic elastase 2. Enzyme Commission Number: EC 3.4.21.71. CAS No. 75603-19-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4163; pancreatic elastase II; EC 3.4.21.71; 75603-19-9; pancreatic elastase 2. Cat No: EXWM-4163. | |
| SF1126 | SF1126 is a water soluble, small-molecule prodrug containing the pan-PI3K/mTOR inhibitor LY294002/SF1101 conjugated to the RGD-containing tetra-peptide SF1174 with potential antineoplastic and antiangiogenic activities. The targeting peptide SF1174 moiety of pan-PI3K/mTOR inhibitor SF1126 selectively binds to cell surface integrins and, upon cell entry, the agent is hydrolyzed to the active drug SF1101; SF1101 selectively inhibits all isoforms of phosphoinositide-3-kinase (PI3K) and other members of the PI3K superfamily, such as the mammalian target of rapamycin (mTOR) and DNA-PK. By inhibiting the PI3K signaling pathway, this agent may inhibit tumor cell and tumor endothelial cell proliferation and survival. Integrins are transmembrane cell adhesion proteins expressed on the surfaces of endothelial and tumor cells. Synonyms: SF 1126, SF-1126. CAS No. 936487-67-1. Molecular formula: C39H48N8O14. Mole weight: 852.84. | |
| WWL70 | WWL70 is a potent inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50 = 70 nM). ABHD6 is a serine hydrolase that is highly expressed in mammalian brain. Synonyms: 4'-carbamoyl-[1,1'-biphenyl]-4-yl methyl(3-(pyridin-4-yl)benzyl)carbamate; WWL 70; WWL70; WWL-70. CAS No. 947669-91-2. Molecular formula: C27H23N3O3. Mole weight: 437.5. | |
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