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| Product | Description | |
|---|---|---|
| Maytansinoid DM4 | DM4 is a cytotoxic agent. It is used as the cytotoxic component in antibody-drug conjugates. Uses: Adcs cytotoxin. Synonyms: N2'-deacetyl-n2'-(4-Mercapto-4-Methyl-1-oxopentyl)-6-MethylMaytansine. Grades: ≥98.0% (HPLC). CAS No. 799840-96-3. Molecular formula: C39H56ClN3O10S. Mole weight: 780.37. |  |
| Maytansinoid DM4 | Maytansinoid DM4 is a cytotoxic agent. It is used as a antibody-drug conjugate that has a potential to treat cancer. Group: Biochemicals. Grades: Highly Purified. CAS No. 799840-96-3. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C39H56ClN3O10S, Molecular Weight: 794.39. US Biological Life Sciences. |  Worldwide |
| Ansamitocin P3 | Ansamitocin P-3 is a metabolite of Ansamitocin which is a new maytansinoid antitumor antibiotic. Fungal metabolite with antineoplastic, antimitotic activity. Binds to tubulin and inhibits vinblastine-induced spiral formation. Group: Biochemicals. Alternative Names: 3-O-De[2-(acetylmethylamino)-1-oxopropyl]-3-O-(1-oxobutyl)-maytansine; 4, 24-Dioxa-9, 22-diazatetracyclo[19. 3. 1. 110, 14. 03, 5]hexacosane, maytansine deriv.; Ansamitocin P 3; Antibiotic C 15003P3; Maytansinol Butyrate. Grades: Purified. CAS No. 66547-09-9. Pack Sizes: 25mg, 50mg, 100mg, 250mg. Molecular Formula: C32H43CIN2O9, Molecular Weight: 635.14. US Biological Life Sciences. | Worldwide |
| Ansamitocin P 3' | Ansamitocin P 3' is an isomer of Ansamitocin P-3, a potent anti-tumor maytansinoid antibiotic found in Actinosynnema pretiosum, a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29. Uses: Adcs cytotoxin. Synonyms: Ansamitocin P3'; AP-3'; Ansamitocin P-3'; Maytansinol butyrate, Maytansinoid AP-3'. Antibiotic C 15003P3'; iso-Ansamitocin P-3. Grades: >98%. CAS No. 66547-09-9. Molecular formula: C32H43ClN2O9. Mole weight: 635.14. | |
| DM1-SMe | DM1-SMe is a potent maytansinoid microtubular inhibitor and an unconjugated DM1 as a mixed disulfide with thiomethane to cap its sulfhydryl group. DM1-SMe can be readily conjugate to the SH group of an antibody to form antibody-drug conjugate (ADC). Group: Inhibitors. Alternative Names: DM1-SMe; DM1-SSMe; SMe-DM4,; maytansinoid derivative with ADC linker. Maytansine or mertansine or emtansine derivative; N2'-deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]maytansine. CAS No. 138148-68-2. Molecular formula: C36H50ClN3O10S2. Mole weight: 784.38. Appearance: White to off-white solid powder. Purity: >98%. IUPACName: N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine. Canonical SMILES: C[C@@H]1[C@@H]2C[C@] (NC (O2)=O) (O)[C@H] (OC)/C=C\C=C (C)\CC3=CC (N (C)C (C[C@@H] (OC ([C@@H] (N (C (CCSSC)=O)C)C)=O)[C@@]4 (C)C1O4)=O)=C (Cl)C (OC)=C3. Catalog: ACM138148682. |  |
| DM3 | DM3 (Maytansinoid DM3) is a maytansine analog bearing disulfide or thiol groups and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Maytansinoid DM3. CAS No. 796073-54-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-130080. |  |
| Indatuximab ravtansine | Indatuximab ravtansine (BT-062) is an antibody-drug conjugate (ADC) ( Antibody-Drug Conjugates (ADCs) ) based on a murine/human chimeric form of B-B4 (specific for CD138), linked to the maytansinoid agent DM4 by disulphide bonds. Indatuximab ravtansine shows anti-tumor activities [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: BT-062; nBT062-DM4. CAS No. 1238517-16-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-141607. | |
| Mirvetuximab soravtansine (solution) | Mirvetuximab soravtansine (IMGN853) solution is an anti-folate receptor α ( FRα ) antibody drug-conjugate (ADC) consisting of the cytotoxic maytansinoid, DM4, covalently linked to the humanized monoclonal antibody M9346A. Mirvetuximab soravtansine selectively binds to folate receptor 1 (FOLR1). Mirvetuximab soravtansine has an anti-proliferative effect via growth arrest and augmented DNA damage [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IMGN853 (solution). CAS No. 1453084-37-1. Pack Sizes: 1 mg (10.246 mg/mL * 97.6 μL in 10mM Histidine pH=5.5); 5 mg (10.246 mg/mL * 488 μL in 10mM Histidine pH=5.5). Product ID: HY-132258A. | |
| N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine | N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine. Group: Biochemicals. Alternative Names: Mertansine, DM 1; Maytansinoid DM 1. Grades: Highly Purified. CAS No. 139504-50-0. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C35H48ClN3O10S. US Biological Life Sciences. | Worldwide |
| N-Methyl-L-alanine hydrochloride | N-Methyl-L-alanine is a reactant used in the preparation of site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity. Synonyms: N-Me-L-Ala-OH HCl; N-Methyl-L-alanine; (2S)-2-(methylamino)propanoic acid. Grades: ≥ 98% (TLC). CAS No. 3913-67-5. Molecular formula: C4H9NO2·HCl. Mole weight: 139.62. | |
| SMCC-DM1 | SMCC-DM1 is a mertansine drug (DM1) with a reactive linker SMCC to make antibody drug conjugate. DM1 (mertansine), a thiol-containing maytansinoid, is a potent microtubule-disrupting agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 1228105-51-8. Pack Sizes: 1mg, 5mg. Molecular Formula: C51H66ClN5O16S, Molecular Weight: 1072.60999999999. US Biological Life Sciences. | Worldwide |
| Trastuzumab emtansine | Trastuzumab emtansine is an antibody-drug conjugate (ADC) consisting of the recombinant anti-epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab conjugated to the maytansinoid DM1 via a nonreducible thioether linkage (MCC) with potential antineoplastic activity. The trastuzumab moiety of this ADC binds to HER2 on tumor cell surface surfaces. Upon internalization, the DM1 moiety is released and binds to tubulin, thereby disrupting microtubule assembly/disassembly dynamics and inhibiting cell division and the proliferation of cancer cells that overexpress HER2. Linkage of antibody and drug through a nonreducible linker has been reported to contribute to the improved efficacy and reduced toxicity of this ADC compared to similar ADCs constructed with reducible linkers. Grades: 95%. CAS No. 1018448-65-1. Molecular formula: C6448H9948N1720O2012S44· (C47H62ClN4O13S)n. | |
| Tusamitamab ravtansine | Tusamitamab ravtansine (SAR-408701) is a targeted ADC against tumor cells expressing CEACAM5 , composed of a humanized anti-CEACAM5 monoclonal antibody covalently linked to the potent cytotoxic agent, maytansinoid DM4 (HY-12454), via a cleavable linker. Tusamitamab ravtansine has an average drug-to-antibody ratio (DAR) of 3.8 [1] [2] [3]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: SAR-408701; HuMAb2-3-SPDB-DM4. CAS No. 2254086-60-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99542. | |
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