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| Product | Description | |
|---|---|---|
| Maytansinoid DM4 | DM4 is a cytotoxic agent. It is used as the cytotoxic component in antibody-drug conjugates. Uses: Adcs cytotoxin. Synonyms: N2'-deacetyl-n2'-(4-Mercapto-4-Methyl-1-oxopentyl)-6-MethylMaytansine. Grade: ≥98.0% (HPLC). CAS No. 799840-96-3. Molecular formula: C39H56ClN3O10S. Mole weight: 780.37. |  |
| Maytansinoid DM4 | Maytansinoid DM4 is a cytotoxic agent. It is used as a antibody-drug conjugate that has a potential to treat cancer. Group: Biochemicals. Grades: Highly Purified. CAS No. 799840-96-3. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C39H56ClN3O10S, Molecular Weight: 794.39. US Biological Life Sciences. |  Worldwide |
| Ansamitocin P3 | Ansamitocin P-3 is a metabolite of Ansamitocin which is a new maytansinoid antitumor antibiotic. Fungal metabolite with antineoplastic, antimitotic activity. Binds to tubulin and inhibits vinblastine-induced spiral formation. Group: Biochemicals. Alternative Names: 3-O-De[2-(acetylmethylamino)-1-oxopropyl]-3-O-(1-oxobutyl)-maytansine; 4, 24-Dioxa-9, 22-diazatetracyclo[19. 3. 1. 110, 14. 03, 5]hexacosane, maytansine deriv.; Ansamitocin P 3; Antibiotic C 15003P3; Maytansinol Butyrate. Grades: Purified. CAS No. 66547-09-9. Pack Sizes: 25mg, 50mg, 100mg, 250mg. Molecular Formula: C32H43CIN2O9, Molecular Weight: 635.14. US Biological Life Sciences. | Worldwide |
| Ansamitocin P 3' | Ansamitocin P 3' is an isomer of Ansamitocin P-3, a potent anti-tumor maytansinoid antibiotic found in Actinosynnema pretiosum, a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29. Uses: Adcs cytotoxin. Synonyms: Ansamitocin P3'; AP-3'; Ansamitocin P-3'; Maytansinol butyrate, Maytansinoid AP-3'. Antibiotic C 15003P3'; iso-Ansamitocin P-3. Grade: >98%. CAS No. 66547-09-9. Molecular formula: C32H43ClN2O9. Mole weight: 635.14. | |
| DM1-SMe | DM1-SMe is a potent maytansinoid microtubular inhibitor and an unconjugated DM1 as a mixed disulfide with thiomethane to cap its sulfhydryl group. DM1-SMe can be readily conjugate to the SH group of an antibody to form antibody-drug conjugate (ADC). Synonyms: DM1-SMe; DM1-SSMe; maytansinoid derivative with ADC linker. Maytansine or mertansine or emtansine derivative; N2'-deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]maytansine. Grade: ≥98%. CAS No. 138148-68-2. Molecular formula: C36H50ClN3O10S2. Mole weight: 784.38. | |
| DM1-SMe | DM1-SMe is a potent maytansinoid microtubular inhibitor and an unconjugated DM1 as a mixed disulfide with thiomethane to cap its sulfhydryl group. DM1-SMe can be readily conjugate to the SH group of an antibody to form antibody-drug conjugate (ADC). Uses: Designed for use in research and industrial production. Additional or Alternative Names: DM1-SMe; DM1-SSMe; SMe-DM4,; maytansinoid derivative with ADC linker. Maytansine or mertansine or emtansine derivative; N2'-deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]maytansine. Product Category: Inhibitors. Appearance: White to off-white solid powder. CAS No. 138148-68-2. Molecular formula: C36H50ClN3O10S2. Mole weight: 784.38. Purity: >98%. IUPACName: N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine. Canonical SMILES: C[C@@H]1[C@@H]2C[C@](NC(O2)=O)(O)[C@H](OC)/C=C\C=C(C)\CC3=CC(N(C)C(C[C@@H](OC([C@@H](N(C(CCSSC)=O)C)C)=O)[C@@]4(C)C1O4)=O)=C(Cl)C(OC)=C3. Product ID: ACM138148682. Alfa Chemistry ISO 9001:2015 Certified. Categories: DMS metro station. |  |
| DM21 | DM21 is a next-generation linker-payload that combines a maytansinoid microtubule-disrupting payload with a stable tripeptide linker. DM21 is conjugated with a humanized antibody against ADAM9 to obtain IMGC936[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2243689-80-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-139441. |  |
| DM3 | DM3 (Maytansinoid DM3) is a maytansine analog bearing disulfide or thiol groups and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Maytansinoid DM3. CAS No. 796073-54-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-130080. | |
| DM4 | DM4 is an anti-tubulin agent that inhibits cell division. DM4 can be used to prepare antibody-drug conjugates. DM4 binds to tubulin at the maytansine-binding site, disrupting microtubule assembly/disassembly dynamics and inhibiting mitosis. Synonyms: Maytansinoid DM 4; Maytansine, N2'-deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-; N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine; Ravtansine. Grade: ≥95%. CAS No. 796073-69-3. Molecular formula: C38H54ClN3O10S. Mole weight: 780.37. | |
| DM4-SPDP | DM4 with a reactive linker SPDP, which can react with antibody to make antibody drug conjugate. DM4 can bind to tubulin at or near the vinblastine-binding site. Synonyms: Maytansinoid DM4- succinimidyl 3-(2-pyridyldithio)propionate; DM4 SPDP. Grade: ≥98%. CAS No. 2245698-48-8. Molecular formula: C45H61ClN4O14S2. Mole weight: 981.57. | |
| Indatuximab ravtansine | Indatuximab ravtansine (BT-062) is an antibody-drug conjugate (ADC) ( Antibody-Drug Conjugates (ADCs) ) based on a murine/human chimeric form of B-B4 (specific for CD138), linked to the maytansinoid agent DM4 by disulphide bonds. Indatuximab ravtansine shows anti-tumor activities [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: BT-062; nBT062-DM4. CAS No. 1238517-16-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-141607. | |
| Mertansine | Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC)[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DM1; Maytansinoid DM1. CAS No. 139504-50-0. Pack Sizes: 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19792. | |
| Mertansine | Mertansine, the cytotoxic component in antibody-drug conjugates, is attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker or SMCC (4-(3-mercapto-2,5-dioxo-1 pyrrolidinylmethyl)-cylohexanecarboxylic acid) linkerto create an antibody-drug conjugate. It derives from a maytansine. Synonyms: (14S,16S,33S,2R,4R,10E,12Z,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-(3-mercaptopropanoyl)-N-methyl-L-alaninate; N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine; DM 1; Maytansinoid DM 1; N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine; DM-1; DM1; DM1 Compound; DM1 [Maytansinoid]. Grade: ≥95%. CAS No. 139504-50-0. Molecular formula: C35H48ClN3O10S. Mole weight: 738.29. | |
| Mirvetuximab soravtansine (solution) | Mirvetuximab soravtansine (IMGN853) solution is an anti-folate receptor α ( FRα ) antibody drug-conjugate (ADC) consisting of the cytotoxic maytansinoid, DM4, covalently linked to the humanized monoclonal antibody M9346A. Mirvetuximab soravtansine selectively binds to folate receptor 1 (FOLR1). Mirvetuximab soravtansine has an anti-proliferative effect via growth arrest and augmented DNA damage [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IMGN853 (solution). CAS No. 1453084-37-1. Pack Sizes: 1 mg (10.246 mg/mL * 97.6 μL in 10mM Histidine pH=5.5); 5 mg (10.246 mg/mL * 488 μL in 10mM Histidine pH=5.5). Product ID: HY-132258A. | |
| N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine | N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine. Group: Biochemicals. Alternative Names: Mertansine, DM 1; Maytansinoid DM 1. Grades: Highly Purified. CAS No. 139504-50-0. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C35H48ClN3O10S. US Biological Life Sciences. | Worldwide |
| N-Methyl-L-alanine hydrochloride | N-Methyl-L-alanine is a reactant used in the preparation of site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity. Synonyms: N-Me-L-Ala-OH HCl; N-Methyl-L-alanine; (2S)-2-(methylamino)propanoic acid. Grade: ≥ 98% (TLC). CAS No. 3913-67-5. Molecular formula: C4H9NO2·HCl. Mole weight: 139.62. | |
| SMCC-DM1 | SMCC-DM1 is a mertansine drug (DM1) with a reactive linker SMCC to make antibody drug conjugate. DM1 (mertansine), a thiol-containing maytansinoid, is a potent microtubule-disrupting agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 1228105-51-8. Pack Sizes: 1mg, 5mg. Molecular Formula: C51H66ClN5O16S, Molecular Weight: 1072.60999999999. US Biological Life Sciences. | Worldwide |
| S-Me-DM4 | S-Me-DM4 is a metabolite of DM4 S-methylated by intracellular enzyme. DM4 (HY-100503) is a microtubule-depolymerizing maytansinoid with strong cytotoxicity. DM4 can be used as an ADC Cytotoxin molecule[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 890654-03-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148818. | |
| sulfo-SPDB-DM4 | DM4 with a reactive linker sulfo-SPDB, which can react with antibody to make antibody drug conjugate. DM4 can bind to tubulin at or near the vinblastine-binding site. Synonyms: Maytansinoid DM4- succinimidyl 4-(N-maleimidomethyl)cyclohexane-3-sulfo-carboxylate. Grade: ≥98%. CAS No. 1626359-59-8. Molecular formula: C46H63ClN4O17S3. Mole weight: 1075.66. | |
| Trastuzumab emtansine | Trastuzumab emtansine is an antibody-drug conjugate (ADC) consisting of the recombinant anti-epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab conjugated to the maytansinoid DM1 via a nonreducible thioether linkage (MCC) with potential antineoplastic activity. The trastuzumab moiety of this ADC binds to HER2 on tumor cell surface surfaces. Upon internalization, the DM1 moiety is released and binds to tubulin, thereby disrupting microtubule assembly/disassembly dynamics and inhibiting cell division and the proliferation of cancer cells that overexpress HER2. Linkage of antibody and drug through a nonreducible linker has been reported to contribute to the improved efficacy and reduced toxicity of this ADC compared to similar ADCs constructed with reducible linkers. Grade: 95%. CAS No. 1018448-65-1. Molecular formula: C6448H9948N1720O2012S44·(C47H62ClN4O13S)n. | |
| Tusamitamab ravtansine | Tusamitamab ravtansine (SAR-408701) is a targeted ADC against tumor cells expressing CEACAM5 , composed of a humanized anti-CEACAM5 monoclonal antibody covalently linked to the potent cytotoxic agent, maytansinoid DM4 (HY-12454), via a cleavable linker. Tusamitamab ravtansine has an average drug-to-antibody ratio (DAR) of 3.8 [1] [2] [3]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: SAR-408701; HuMAb2-3-SPDB-DM4. CAS No. 2254086-60-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99542. | |
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