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| Product | Description | |
|---|---|---|
| MCA | MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities [1] [2]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 62935-72-2. Pack Sizes: 100 mg; 250 mg; 500 mg. Product ID: HY-W027544. |  |
| MCA | MCA. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 7-Methoxycoumarin-4-acetic acid. Product Category: Other Fluorophores. CAS No. 62935-72-2. Molecular formula: C12H10O5. Mole weight: 234.2. Product ID: ACM62935722. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Mca-Ala-Pro-Lys(Dnp)-OH | Mca-Ala-Pro-Lys(Dnp)-OH, a FRET substrate for angiotensin-converting enzyme 2 (ACE2), is used to monitor enzyme activity in plasma, urine, heart and lungs. Synonyms: Mca-APK(Dnp); L-Lysine, N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-alanyl-L-prolyl-N6-(2,4-dinitrophenyl)-; N-[(7-Methoxy-2-oxo-2H-chromen-4-yl)acetyl]-L-alanyl-L-prolyl-N6-(2,4-dinitrophenyl)-L-lysine; (S)-6-((2,4-dinitrophenyl)amino)-2-((S)-1-((S)-2-(2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetamido)propanoyl)pyrrolidine-2-carboxamido)hexanoic acid. Grades: ≥95%. CAS No. 305336-82-7. Molecular formula: C32H36N6O12. Mole weight: 696.67. |  |
| Mca-Amyloid β/A4 Protein Precursor770 (667-676)-Lys(Dnp)-Arg-Arg amide | Mca-Amyloid β/A4 Protein Precursor770 (667-676)-Lys(Dnp)-Arg-Arg amide, a fluorescent (FRET) peptide substrate containing the wild-type amyloid precursor protein (APP) β-secretase cleavage site, is used to determine the β-secretase-like activity of thimet oligopeptidase (TOP, EC 3.4.24.15). TOP is a potential β-secretase candidate and is involved in APP processing in vivo. Synonyms: Mca-APP770 (667-676)-Lys(Dnp)-Arg-Arg amide; Mca-Ser-Glu-Val-Lys-Met-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg-NH2; Mca-SEVKMDAEFRK(Dnp)RR-amide. Grades: ≥95% by HPLC. CAS No. 1802078-33-6. Molecular formula: C87H129N27O28S. Mole weight: 2033.21. | |
| Mca-[Asn670, Leu671]-Amyloid ?/A4 Precursor Protein 770 fragment 667-675-(Dnp)Lys amide | ?96% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. |  |
| Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) | Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) is a pro-memapsin-2 fluorogenic substrate (FRET) containing the β-secretase site of the Swedish mutation of APP, SEVNLDAEF. Synonyms: Mca-(Asn670,Leu671)-APP770 (667-675)-Lys(Dnp); Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(Dnp)-OH; N-[(7-Methoxy-2-oxo-2H-chromen-4-yl)acetyl]-L-seryl-L-α-glutamyl-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-L-lysine; L-Lysine, N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-seryl-L-α-glutamyl-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-. Grades: ≥95%. CAS No. 1802078-31-4. Molecular formula: C68H88N14O27. Mole weight: 1533.53. | |
| Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) amide | Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) amide is a fluorogenic (FRET) substrate for pro-memapsin-2 containing the β-secretase site of the Swedish mutation of APP. Its kinetic parameters at pH 4.5 are Km = 4.5 μM and kcat = 0.25 min-1. Synonyms: Mca-(Asn670,Leu671)-APP770 (667-675)-Lys(Dnp) amide; Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(Dnp)-NH2; N-[(7-Methoxy-2-oxo-2H-chromen-4-yl)acetyl]-L-seryl-L-α-glutamyl-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-L-lysinamide; L-Lysinamide, N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-seryl-L-α-glutamyl-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-; Mca-SEVNLDAEFK(Dnp) amide. Grades: ≥95%. CAS No. 1802078-32-5. Molecular formula: C68H89N15O26. Mole weight: 1532.54. | |
| Mca-(endo-1a-dap(dnp))-tnf-alpha(-5 to +6)amide(human) | Mca-(endo-1a-dap(dnp))-tnf-alpha(-5 to +6)amide(human). Uses: Designed for use in research and industrial production. Additional or Alternative Names: ADAM-17 SUBSTRATE II, FLUOROGENIC;MCA-(ENDO-1A-DAP(DNP))-TNF-A (-5 TO +6) AMIDE (HUMAN);MCA-(ENDO-1A-DAP(DNP))-TNF-ALPHA (-5 TO +6) AMIDE (HUMAN);MCA-(ENDO-1A-DAP(DNP))-TUMOR NECROSIS FACTOR-ALPHA (-5 TO +6) AMIDE (HUMAN);MCA-PRO-LEU-ALA-GLN-ALA-VAL-DAP(. Product Category: Heterocyclic Organic Compound. CAS No. 192723-42-5. Molecular formula: C69H103N23O24. Mole weight: 1638.7. Product ID: ACM192723425. Alfa Chemistry ISO 9001:2015 Certified. | |
| Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH2 | Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH2, a FRET substrate for cathepsin D and E, is also cleaved by napsin A. Synonyms: MOCAc-GKPILFFRL-{Lys(Dnp)}-{D-Arg}-NH2; Mca-GKPILFFRL-Dpa-r-amide; MOCAc-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-{Lys(Dnp)}-{D-Arg}-NH2; N-[(7-Methoxy-2-oxo-2H-chromen-4-yl)acetyl]glycyl-L-lysyl-L-prolyl-L-isoleucyl-L-leucyl-L-phenylalanyl-L-phenylalanyl-L-arginyl-L-leucyl-N6-(2,4-dinitrophenyl)-L-lysyl-D-argininamide; D-Argininamide, N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]glycyl-L-lysyl-L-prolyl-L-isoleucyl-L-leucyl-L-phenylalanyl-L-phenylalanyl-L-arginyl-L-leucyl-N6-(2,4-dinitrophenyl)-L-lysyl-; Cathepsin D and E FRET Substrate. Grades: ≥90%. CAS No. 839730-93-7. Molecular formula: C85H122N22O19. Mole weight: 1756.01. | |
| MCA-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Lys(DNP)-NH2 trifluoroacetate salt | ?95% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. | |
| MCA-Lys-Leu-Lys(Dnp) | Synonyms: N6-(2,4-dinitrophenyl)-N2-(2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetyl)-L-lysyl-L-leucyl-L-lysine. Molecular formula: C36H47N7O12. Mole weight: 769.81. | |
| mCAP | Used for in vitro transcription of 5'-capped mRNA to generate Cap 0 structure. mCAP has a 50% chance of inserting in the right direction to enhance translation. Another 50% of the molecules cannot become effective translation substrates, which reduces the specific activity of the transcript. Synonyms: m7G(5')ppp(5')G Cap Analog; N7-Methyl-Guanosine-5'-Triphosphate-5'-Guanosine; 7-Methyl-guanosine-5'-triphosphate-5'-guanosine; M7-GpppG. Grades: ≥90% by AX-HPLC. Molecular formula: C21H30N10O18P3 (free acid). Mole weight: 803.44 (free acid). | |
| Mca-pro-leu-gly-pro-D-lys(dnp)-oh | Mca-pro-leu-gly-pro-D-lys(dnp)-oh. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MCA-PRO-LEU-GLY-PRO-DLYS(DNP);MCA-PRO-LEU-GLY-PRO-D-LYS(DNP)-OH. Product Category: Heterocyclic Organic Compound. CAS No. 185698-23-1. Molecular formula: C42H52N8O14. Mole weight: 892.91. Product ID: ACM185698231. Alfa Chemistry ISO 9001:2015 Certified. | |
| Mca-SEVNLDAEFK(Dnp)-NH2 | Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1 [1]. Uses: Scientific research. Group: Peptides. CAS No. 1802078-32-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4920. | |
| MCA-SEVNLDAEFR-K(Dnp)-RR, amide | It is a FRET-based substrate. Synonyms: Mca-(Asn670, Leu671)-APP770(667-676)-Lys(Dnp)-Arg-Arg amide; MCA-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg-NH2; Mca-(Asn670, Leu671)-Amyloid beta/A4 Protein Precursor770(667-676)-Lys(Dnp)-Arg-Arg amide. Grades: ≥95%. CAS No. 438625-61-7. Molecular formula: C86H125N27O29. Mole weight: 2001.08. | |
| Mca-tyr-val-ala-asp-ala-pro-lys(dnp)-oh | Mca-tyr-val-ala-asp-ala-pro-lys(dnp)-oh. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MCA-TYR-VAL-ALA-ASP-ALA-PRO-LYS(DNP);MCA-TYR-VAL-ALA-ASP-ALA-PRO-LYS(DNP)-OH;MCA-YVADAP-K(DNP);MCA-YVADAPK(DNP)-NH2;MCA-YVADAPK(DNP)-OH;MCA-YVADPK (DNP);ICE SUBSTRATE V, FLUOROGENIC;CASPASE-1 SUBSTRATE IX, FLUOROGENIC. Product Category: Heterocyclic Organic Compound. CAS No. 189696-01-3. Molecular formula: C53H64N10O19. Mole weight: 1145.13. Product ID: ACM189696013. Alfa Chemistry ISO 9001:2015 Certified. Categories: Mca-YVADAP-Lys(Dnp)-OH (TFA). | |
| BOC-GLU-LYS-LYS-MCA | BOC-GLU-LYS-LYS-MCA is a sensitive fluorogenic substrate for urokinase-activated plasmin. Synonyms: T-BUTYLOXYCARBONYL-L-GLUTAMYL-L-LYSYL-L-LYSINE 4-METHYLCOUMARYL-7-AMIDE; BOC-GLU-LYS-LYS-AMC ACETATE SALT; BOC-GLU-LYS-LYS-AMC ACOH; BOC-GLU-LYS-LYS-MCA; Boc-Glu-Lys-Lys-AMC; N-T-boc-glu-lys-lys 7-amido-4-*methylcoumarin; N-tert-BOC-Glu-Lys 7-amido-4-methylcou. Grades: ≥97%. CAS No. 73554-85-5. Molecular formula: C32H48N6O9. Mole weight: 660.76. | |
| Boc-glu(obzl)-gly-arg-mca hydrochloride | Boc-glu(obzl)-gly-arg-mca hydrochloride. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BOC-GLU(OBZL)-GLY-ARG-MCA HYDROCHLORIDE;T-BUTYLOXYCARBONYL-[(2S)-2-AMINO-4-(BENZYLOXYCARBONYL)BUTANOYL]GLYCYL-L-ARGININE 4-METHYLCOUMARYL-7-AMIDE HYDROCHLORIDE. Product Category: Heterocyclic Organic Compound. CAS No. 73554-94-6. Molecular formula: C35H45N7O9. Mole weight: 707.77. Product ID: ACM73554946. Alfa Chemistry ISO 9001:2015 Certified. | |
| Boc-Val-Leu-Lys-MCA | Boc-VLK-AMC is a sensitive, fluorogenic, and specific substrate for the quantitative measurement of plasmin. Synonyms: Boc-Val-Leu-Lys-7-amido-4-methylcoumarin; N-(tert-Butoxycarbonyl)-L-valyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-lysinamide. CAS No. 73554-84-4. Molecular formula: C32H49N5O7. Mole weight: 615.77. | |
| BOC-VAL-PRO-ARG-MCA TFA salt | BOC-VAL-PRO-ARG-MCA is a specific, highly fluorogenic substrate for thrombin and the thrombin-staphylocoagulase complex. Synonyms: Boc-Val-Pro-Arg-4-methylcoumaryl-7-amide TFA salt; Boc-Val-Pro-Arg-4-methyl-7-coumarylamide TFA salt. Molecular formula: C33H46F3N7O9. Mole weight: 741.76. | |
| pGlu-Arg-Thr-Lys-Arg-MCA | Synonyms: Pyr-Arg-Thr-Lys-Arg-AMC; L-Argininamide, 5-oxo-L-prolyl-L-arginyl-L-threonyl-L-lysyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-; l-pyroglutamyl-l-arginyl-l-threonyl-l-lysyl-l-arginine 4-methylcoumaryl-7-amide. CAS No. 155575-02-3. Molecular formula: C37H57N13O9. Mole weight: 827.93. | |
| Z-Gly-Pro-Arg-Mca Hydrochloride | Z-GPR-AMC is a fluorogenic substrate for cathepsin K, granzyme A, and thrombin. Synonyms: Z-Gly-Pro-Arg-AMC HCl; L-Argininamide, N-[(phenylmethoxy)carbonyl]glycyl-L-prolyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-,monohydrochloride(9ci). CAS No. 201928-42-9. Molecular formula: C31H38ClN7O7. Mole weight: 656.13. | |
| 2-Benzyloxyphenylboronic acid | 2-Benzyloxyphenylboronic acid. Group: Salt. Alternative Names: AKOS BRN-0079; 2-BENZYLOXYBENZENEBORONIC ACID; 2-BENZYLOXYPHENYLBORONIC ACID; RARECHEM AH PB 0042; O-BENZYLOXYPHENYLBORONIC ACID; 2-Phenylmethoxy Phenylboronic Acid; 2-BENZYLOXYPHENYLBORORNIC ACID; 2-Benzyloxyphenylboronic. CAS No. 190661-29-1. Product ID: [2-(phenylmethoxy)phenyl]boronic acid. Molecular formula: 228.05. Mole weight: C13< / sub>H13< / sub>BO3< / sub>. B(C1=CC=CC=C1OCC2=CC=CC=C2)(O)O. MCAIDINWZOCYQK-UHFFFAOYSA-N. 98%. |  |
| 4-Methoxycinnamic Acid | p-MCA exerted antihyperglycemic / hypoglycemic effect by stimulating insulin secretion from pancreas and could be developed into a new potential for therapeutic agent used in type 2 diabetic patients. Group: Biochemicals. Grades: Highly Purified. CAS No. 830-09-1. Pack Sizes: 1g, 10g, 25g, 100g, 250g. Molecular Formula: C??H??O?. US Biological Life Sciences. |  Worldwide |
| 7-Methoxycoumarin-4-acetic acid | Key intermidiate for the synthesis of fluorescence probes in chromatographic detection. Shows local anesthetic activity. Synonyms: 7-Methoxy-2-oxo-2H-1-benzopyran-4-acetic acid; Mca-OH; 2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetic acid; 2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetic acid; 2H-1-Benzopyran-4-acetic acid, 7-methoxy-2-oxo-; Mca-OH. Grades: ≥ 98% (HPLC). CAS No. 62935-72-2. Molecular formula: C12H10O5. Mole weight: 234.20. | |
| 7-Methoxycoumarin-4-acetic Acid N-Succinimidyl Ester | Synonyms: 1-[[(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]oxy]-2,5-Pyrrolidinedione; Mca-OsuN-(7-methoxycoumarin-4-acetyloxy)succinimide; 7-Methoxy-4-coumarinylacetic acid N-succinimidyl ester; N-(7-methoxycoumarin-4-acetyloxy)succinimide; Mca-OSu; 2,5-Dioxopyrrolidin-1-yl 2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetate. Grades: 95%. CAS No. 359436-89-8. Molecular formula: C16H13NO7. Mole weight: 331.28. | |
| Acetyl-L-alanine 7-amido-4-methylcoumarin | Synonyms: Ac-Ala-MCA; (S)-2-Acetamido-N-(4-Methyl-2-Oxo-2H-Chromen-7-Yl)Propanamide; W-204221; CTK8E7034. CAS No. 355137-87-0. Molecular formula: C15H16N2O4. Mole weight: 288.30. | |
| [acyl-carrier-protein] S-malonyltransferase | This enzyme, along with EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, is essential for the initiation of fatty-acid biosynthesis in bacteria. This enzyme also provides the malonyl groups for polyketide biosynthesis. The product of the reaction, malonyl-ACP, is an elongation substrate in fatty-acid biosynthesis. In Mycobacterium tuberculosis, holo-ACP (the product of EC 2.7.8.7, holo-[acyl-carrier-protein] synthase) is the preferred substrate. This enzyme also forms part of the multienzyme complexes EC 4.1.1.88 (biotin-independent malonate decarboxylase) and EC 4.1.1.89 (biotin-dependent malonate decarboxylase). Malonylation of ACP is immediately followed by d... malonyl coenzyme A-acyl carrier protein transacylase; malonyl transacylase; malonyl transferase; malonyl-CoA-acyl carrier protein transacylase; malonyl-CoA:[acyl-carrier-protein] S-malonyltransferase; malonyl-CoA:ACP transacylase; malonyl-CoA:ACP-SH transacylase; malonyl-CoA:AcpM transacylase; malonyl-CoA:acyl carrier protein transacylase; malonyl-CoA:acyl-carrier-protein transacylase; malonyl-CoA/dephospho-CoA acyltransferase; MAT; MCAT; MdcH. Enzyme Commission Number: EC 2.3.1.39. CAS No. 37257-17-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2217; [acyl-carrier-protein] S-malon |  |
| a-D-Mannose-1-phosphate dipotassium salt | a-D-Mannose-1-phosphate dipotassium salt, a promising compound in the biomedical sector, has been researched extensively for its potential therapeutic effects on genetic diseases that interfere with carbohydrate metabolism, one such being glycogen storage disease type V (McArdle disease). Additionally, this compound has demonstrated potential for the development of antiviral therapy and treatments for bacterial infections. CAS No. 71888-67-0. Molecular formula: C6H11K2O9P. Mole weight: 336.32. | |
| Akt Activator II, SC79 (Ethyl-2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate) | A cell-permeable and blood-brain barrier permeant HA14-1 analog that interacts with Akt PH domain PtdIns(3,4,5)P3- (PIP3) binding pocket, rendering Akt in a conformation susceptible to phosphorylation by upstream kinases. Shown to enhance both basal and receptor-mediated Akt phosphorylation (Thr308 and Ser473; 2 to 4ug/ml) with concomitant inhibition Akt membrane translocation in various cell cultures. Efficiently reduces glutamate-induced neurotoxicity both in primary neuron cultures (EC50 = 4ug/ml) in vitro and in a murine MCAO model (40mg/kg, i.p.) in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 305834-79-1. Pack Sizes: 25mg. Molecular Formula: C??H??ClN?O?. US Biological Life Sciences. | Worldwide |
| ARCA | Used for in vitro transcription of 5'-capped mRNA to generate Cap 0 structure. ARCA can only be inserted in the correct direction, and the resulting mRNA is translated twice as efficiently as the mRNA initiated by mCAP. Synonyms: Anti Reverse Cap Analog; m7(3'-O-methy)G(5')ppp(5')G; 3´-O-Me-m7G(5')ppp(5')G. Grades: ≥95% by AX-HPLC. Molecular formula: C22H32N10O18P3 (free acid). Mole weight: 817.47 (free acid). | |
| Bis[2-(2-pyridinyl-N)phenyl-C](2,4-pentanedionato-O2,O4)iridium(III) | Bis[2-(2-pyridinyl-N)phenyl-C](2,4-pentanedionato-O2,O4)iridium(III). Uses: (ppy)2ir(acac) used in green phosphorescent oled devices as dopant/emitter achieved high brightness of 130800 cd m_2 at a current density of 1550 ma cm_2 (13 v), and high quantum efficiency (15~16%). Group: Organic light-emitting diode (oled) materials. Alternative Names: (ppy)2Ir(acac), Bis[2-(2-pyridinyl-N)phenyl-C](acetylacetonato)iridium(III), Ir(ppy)2(acac). CAS No. 337526-85-9. Pack Sizes: 250 mg in glass insert. Molecular formula: 599.7. CC(=O)[CH-]C(C)=O.[Ir+](c1ccccc1-c2ccccn2)c3ccccc3-c4ccccn4. 1S/2C11H8N. C5H7O2. Ir/c2*1-2-6-10 (7-3-1)11-8-4-5-9-12-11; 1-4 (6)3-5 (2)7; /h2*1-6, 8-9H; 3H, 1-2H3; /q; ; -1; +1, MCAGFPRRYUPGMD-UHFFFAOYSA-N. MCAGFPRRYUPGMD-UHFFFAOYSA-N. | |
| BMS 191011 | BMS 191011 is a potent opener of the large-conductance, Ca2+-activated potassium (maxi-K) channel. It is neuroprotectant in two distinct animal models of stroke (MCAO in the SHR rat and a normotensive model of focal stroke). Synonyms: 3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-one; BMS-191011; BMS 191011; BMS191011; UNII-LW7MXS978N; Bms-a. Grades: >99 %. CAS No. 202821-81-6. Molecular formula: C16H10ClF3N3O3. Mole weight: 370.71. | |
| Boc-asp(obzl)-pro-arg-amc hcl | Boc-asp(obzl)-pro-arg-amc hcl. Uses: Designed for use in research and industrial production. Additional or Alternative Names: T-BUTYLOXYCARBONYL-[(2S)-2-AMINO-3-(BENZYLOXYCARBONYL)PROPIONYL]-L-PROLYL-L-ARGININE 4-METHYLCOUMARYL-7-AMIDE;N-T-BOC-BETA-BENZYL-ASP-PRO-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE;BOC-ASP(OBZL)-PRO-ARG-AMC HCL;BOC-ASP(OBZL)-PRO-ARG-MCA;N-T-boc-B-benzyl-. Product Category: Heterocyclic Organic Compound. CAS No. 113866-00-5. Molecular formula: C37H48ClN7O9. Mole weight: 770.27. Product ID: ACM113866005. Alfa Chemistry ISO 9001:2015 Certified. Categories: 201849-39-0. | |
| Boc-Gln-Arg-Arg-AMC | Boc-QRR-AMC is a substrate for the transmembrane serine protease hepsin, also is used for assaying kexin. Synonyms: Boc-Gln-Arg-Arg-Mca; tert-butyl (S)-5-amino-1-((S)-5-guanidino-1-((S)-5-guanidino-1-(4-methyl-2-oxo-2H-chromen-7-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1,5-dioxopentan-2-ylcarbamate; Boc-QRR-AMC. Grades: 95%. CAS No. 109376-05-8. Molecular formula: C32H49N11O8. Mole weight: 715.81. | |
| Boc-ile-glu-gly-arg-7-amido-4-methylcoumarin acetate salt | Boc-ile-glu-gly-arg-7-amido-4-methylcoumarin acetate salt. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Biggam, Boc-ile-glu-gly-arg-mca, CID196426, tertiary-Butyloxycarbonyl-isoleucyl-glutamyl-glycyl-arginyl-7-amino-4-methylcoumarin, 65147-06-0, L-Argininamide, N-((1,1-dimethylethoxy)carbonyl)-L-isoleucyl-L-alpha-glutamylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-. Appearance: WHITE POWDER. CAS No. 65147-06-0. Molecular formula: C34H50N8O10. Mole weight: 730.81. Purity: 95%+. IUPACName: (4S)-5-[[2-[[(2S)-5-(diaminomethylideneamino)-2-[(4-methyl-2-oxochromen-7-yl)amino]pentanoyl]amino]-2-oxoethyl]amino]-4-[[(2S,3S)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoyl]amino]-5-oxopentanoic acid. Canonical SMILES: CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NCC(=O)NC(=O)C(CCCN=C(N)N)NC1=CC2=C(C=C1)C(=CC(=O)O2)C)NC(=O)OC(C)(C)C. Density: 1.36 g/cm³. Product ID: ACM65147060. Alfa Chemistry ISO 9001:2015 Certified. Categories: Boc-Ile-Glu-Gly-Arg-AMC. | |
| Boc-lys(tfa)-amc | Boc-lys(tfa)-amc. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Boc-L-Lys-MCA, Boc-Lys(Tfa)-AMC, CHEMBL402788, CTK8F8298, AG-H-98298, (S)-tert-Butyl (1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxo-6-(2,2,2-trifluoroacetamido)hexan-2-yl)carbamate, 97885-44-4. Product Category: Heterocyclic Organic Compound. CAS No. 97885-44-4. Molecular formula: C23H28F3N3O6. Mole weight: 499.49. Purity: 0.96. IUPACName: tert-butyl N-[(2S)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxo-6-[(2,2,2-trifluoroacetyl)amino]hexan-2-yl]carbamate. Canonical SMILES: CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C(CCCCNC(=O)C(F)(F)F)NC(=O)OC(C)(C)C. Product ID: ACM97885444. Alfa Chemistry ISO 9001:2015 Certified. | |
| Boc-Lys(Tfa)-AMC | Boc-Lys(Tfa)-AMC is a fluorogenic substrate for the assaying of histone deacetylase (HDAC) 4, 5 and 7 activity in a protease-coupled assay. Synonyms: tert-butyl N-[(2S)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxo-6-[(2,2,2-trifluoroacetyl)amino]hexan-2-yl]carbamate; (S)-tert-Butyl (1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxo-6-(2,2,2-trifluoroacetamido)hexan-2-yl)carbamate; Boc-L-Lys-MCA; Boc L Lys MCA. Grades: 98%. CAS No. 97885-44-4. Molecular formula: C23H28F3N3O6. Mole weight: 499.49. | |
| Boc-Phe-Ser-Arg-AMC AcOH | Synonyms: Boc-Phe-Ser-Arg-4-Methylcoumaryl-7-Amide; T-Butyloxycarbonyl-Phe-Ser-Arg-Mca. Grades: ≥ 98% (TLC). CAS No. 73554-90-2. Molecular formula: C33H43N7O8·C2H4O2. Mole weight: 725.9. | |
| Boc-val-leu-lys-amc acetate | Boc-val-leu-lys-amc acetate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: tertiarybutyloxycarbonylvalyl-leucyl-lysinyl-4-methylcoumarin-7-amide;BOC-VAL-LEU-LYS-7-AMIDO-4-METHYLCOUMARIN;BOC-VAL-LEU-LYS-AMC ACETATE;BOC-VAL-LEU-LYS-AMC ACOH;BOC-VAL-LEU-LYS-MCA;T-BUTYLOXYCARBONYL-L-VALYL-L-LEUCYL-L-LYSINE 4-METHYLCOUMARYL-7-AMIDE. Product Category: Heterocyclic Organic Compound. CAS No. 73554-84-4. Molecular formula: C32H49N5O7. Mole weight: 615.77. Product ID: ACM73554844. Alfa Chemistry ISO 9001:2015 Certified. | |
| BTB-1 | BTB-1 is a novel small molecule inhibitor of the mitotic motor protein Kif18A, which was identified by Catarinella et al. during a highthroughput screen against Kif18A's MT-stimulated ATPase activity, with an IC50 of 1.7-1.9 M. It is selective within the kinesin subgroup of Kif4, Eg5, MKLP-1, MKLP-2, MPP1, CENP-E and MCAK, and during in vitro motility assays Kif18A's MT gliding ability was blocked by the addition of BTB-1 in a reversible manner. BTB-1 was found to be ATP competitive and MT uncompetitive, only inhibiting the ATPase activity of the MT-bound motor protein. BTB-1 could serve as a valuable tool in disentangling the nature of Kif18A's double functionality within mitosis and assessing for potential therapeutic utilities. Synonyms: BTB 1; BTB1; 4-Chloro-2-nitro-1-(phenylsulfonyl)benzene; 4-Chloro-2-nitrodiphenyl sulfone; NSC 156750. CAS No. 86030-08-2. Molecular formula: C12H8ClNO4S. Mole weight: 297.71. | |
| Creatine Kinase MB Isoenzyme Type-1 from Human, Recombinant | The three isoenzymes (MM, MB, and BB) are found in muscle, cardiac and brain tissues. These recombinant proteins are ideal for calibrating diagnostic instruments and researching neuromuscular diseases. Creatine Kinases can be used for indications in many neuromuscular applications. These disorders include cardiac disease, mitochondrial disorders, inflammatory myopathies, myasthenia, polymyositis, McArdle's disease, NMJ disorders, muscular dystrophy, ALS, hypo and hyperthyroid disorders, central core disease, acid maltase deficiency, myoglobinuria, rhabdomyolysis, motor neuron diseases, rheumatic diseases, and other that create elevated or reduced levels of Creat... in elisa. the ckmbiti is purified by proprietary chromatographic techniques. Group: Enzymes. Synonyms: Creatine Kinase MB Isoenzyme Type-I; Creatine Kinase MB Isoenzyme Type-1; CKMBITI; CKMBI; CKMB; CKMBT1. Purity: Greater than 95.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. CK. Activity: 500 IU/mg. Stability: CKMBITI although stable at 15°C for 7 days, should be stored below -18°C. Please prevent freeze-thaw cycles. Appearance: Sterile Filtered colourless liquid formulation. Source: Pichia Pastoris. Species: Human. Creatine Kinase MB Isoenzyme Type-I; Creatine Kinase MB Isoenzyme Type-1; CKMBITI; CKMBI; CKMB; CKMBT1. Cat No: NATE-0818. | |
| cyclic alcohol dehydrogenase (quinone) | This enzyme oxidizes a wide variety of cyclic alcohols. Some minor enzyme activity is found with aliphatic secondary alcohols and sugar alcohols, but not primary alcohols. The enzyme is unable to catalyse the reverse reaction of cyclic ketones or aldehydes to cyclic alcohols. This enzyme differs from EC 1.1.5.5, alcohol dehydrogenase (quinone), which shows activity with ethanol. Group: Enzymes. Synonyms: cyclic alcohol dehydrogenase; MCAD. Enzyme Commission Number: EC 1.1.5.7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0435; cyclic alcohol dehydrogenase (quinone); EC 1.1.5.7; cyclic alcohol dehydrogenase; MCAD. Cat No: EXWM-0435. | |
| Fexaramine | Fexaramine is a potent and selective FXR agonist with an EC 50 of 25 nM. Fexaramine has no activity against hRXRα, hPPARαγδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ, and hVDR receptors [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 574013-66-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-10912. | |
| Ficlatuzumab | Ficlatuzumab is a monoclonal antibody (McAb) targeting human hepatocyte growth factor ( HGF ). Ficlatuzumab blocks the activation of the HGF/c-Met signaling pathway, and inhibits c-Met receptor-mediated cancer cell proliferation, migration, and invasion [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 1174900-84-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99196. | |
| Fmoc-Lys(Dabcyl)-OH | A modified lysine derivative for the preparation of chromogenically-labeled peptides by Fmoc SPPS. The Dabcyl group quenches the fluorescence of EDANS, Mca, TET, JOE, FAM fluorophores, making it an extremely useful tool for the synthesis of fluorescence-quenched peptide substrates. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Lys(Dabcyl)-OH. Product Category: Amino Acids. CAS No. 146998-27-8. Molecular formula: C36H37N5O5. Mole weight: 619.71. Product ID: ACM146998278-1. Alfa Chemistry ISO 9001:2015 Certified. | |
| Glycine-β-muricholic Acid | Glycine-β-muricholic acid (GβMCA) is a potent, oral bioactive and intestine-selective antagonist of the farnesoid X receptor (FXR) that may be a candidate for the treatment of metabolic disorders. Synonyms: Gly-MCA; GβMCA; N-[(3α,5β,6β,7β)-3,6,7-trihydroxy-24-oxocholan-24-yl]-glycine; 5β-Cholanic acid-3α,6β,7β-triol N-(carboxymethyl)-amide. Grades: ≥95%. CAS No. 66225-78-3. Molecular formula: C26H43NO6. Mole weight: 465.63. | |
| GR 135531 | GR 135531 is a high affinity agonist of MT3 melatonin receptors, with low affinity for MT1 and MT2 melatonin receptors. GR 135531 can be used to discriminate between the melatonin receptor subtypes. Synonyms: GR 135531; GR135531; GR-1355315-Methoxycarbonylamino-N-acetyltryptamine; 5-MCA-NAT; methyl N-[3-(2-acetamidoethyl)-1H-indol-5-yl]carbamate. Grades: ≥97% by HPLC. CAS No. 190277-13-5. Molecular formula: C14H17N3O3. Mole weight: 275.31. | |
| Histatin-3 TFA | Histatin-3 TFA, a 32 amino acid peptide, possesses powerful antimicrobial properties. Histatin-3 TFA behaves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at a site carboxy terminal to the single Arg25 residue (HRGYR decrease SN). Histatin-3 TFA is a moderately potent, reversible and competitive inhibitor of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an estimated inhibition constant K i of 1.98 μM [1]. Uses: Scientific research. Group: Peptides. CAS No. 112844-49-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5272. | |
| H-Pro-phe-arg-amc acetate salt | H-Pro-phe-arg-amc acetate salt. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pro-phe-arg-mca, CID174085, Prolyl-phenylalanyl-arginine-4-methylcoumaryl-7-amide, L-Argininamide, L-prolyl-L-phenylalanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-, 65147-21-9. Product Category: Heterocyclic Organic Compound. CAS No. 65147-21-9. Molecular formula: C30H37N7O5. Mole weight: 575.67. Purity: 0.96. IUPACName: (2S)-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-2-[(4-methyl-2-oxochromen-7-yl)amino]pentanoyl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide. Density: 1.39g/cm³. Product ID: ACM65147219. Alfa Chemistry ISO 9001:2015 Certified. | |
| Imazalil | Imazalil (Enilconazole) is a fungicide. Imazalil has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil is commonly used to protect various agricultural crops against fungal attack. Imazalil induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Enilconazole. CAS No. 35554-44-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B1134. | |
| LJP 1586 | LJP 1586, under the IUPAC name Benzenepropanamine, β-(fluoromethylene)?-4-methoxy-, hydrochloride (1:1)?, (βZ)?-, a selective vascular adhesion protein (VAP-1) blocker that has been shown to be beneficial against transient forebrain ischemia and transient middle cerebral artery occlusion(MCAo) and to prevent leukocyte adhesion and parenchymal infiltration and improve sneurologic status after SAH. Uses: Treat human stroke or other neuropathy?/nervous system disorder; a selective vascular adhesion protein (vap-1) blocker; anti-inflammatory. Synonyms: LJP 1586; LJP1586; LJP-1586; Benzenepropanamine, β-(fluoromethylene)?-4-methoxy-, hydrochloride (1:1)?, (βZ)?-; (Z)-3-fluoro-2-(4-Methoxybenzyl)allylamine. CAS No. 955037-42-0. Molecular formula: C11H15ClFNO. Mole weight: 231.69. | |
| Maurocalcine | Maurocalcine is a highly potent cell-penetrating peptide isolated from the Tunisian scorpion Maurus palmatus. It is an activator of Ca2+ release channel and a Ryanodine receptors agonist. It is a 33-mer basic peptide cross-linked by three disulfide bridges. Synonyms: MCa. Grades: >97%. | |
| mycothiol S-conjugate amidase | The enzyme that is found in actinomycetes is involved in the detoxification of oxidizing agents and electrophilic antibiotics. The enzyme has low activity with 1-O-(2-acetamido-2-deoxy-α-D-glucopyranosyl)-1D-myo-inositol as substrate (cf. EC 3.5.1.103, N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-α-D-glucopyranoside deacetylase). Group: Enzymes. Synonyms: MCA. Enzyme Commission Number: EC 3.5.1.115. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4395; mycothiol S-conjugate amidase; EC 3.5.1.115; MCA. Cat No: EXWM-4395. | |
| N- (3-Phenylpropionyl) glycine | N- (3-Phenylpropionyl) glycine detection is a useful diagnostic tool in the diagnosis of many organic acidemias and mitochondrial fatty acid β-oxidation defects. N- (3-Phenylpropionyl) glycine is present in the urine of medium-chain acyl-CoA dehydrogenase deficient (MCAD) patients who orally ingested 3-phenylpropionic acid. Group: Biochemicals. Alternative Names: N-(1-oxo-3-phenylpropyl)glycine; (3-Phenylpropionyl) glycine; N- (3-Phenylpropanoyl) glycine. Grades: Highly Purified. CAS No. 56613-60-6. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| Nα-Benzoyl-L-arginine 7-amido-4-methylcoumarin hydrochloride | Sensitive fluorogenic A substrate for trypsin, soybean trypsin-like enzyme, and papain. Synonyms: Bz-L-Arg-AMC HCl; BENZOYL-L-ARGININE 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE; BZ-ARG-AMC HCl; BZ-ARG-MCA(HYDROCHLORIDE FORM); Nalpha-Benzoyl-L-arginine-7-amido-4-methylcoumarin hydrochloride; Nalpha-Benzoyl-L-arginine-7-amido-4-methylcoumarin hydrochloride. Grades: ≥ 95%. CAS No. 83701-04-6. Molecular formula: C23H25N5O4·HCl. Mole weight: 471.94. | |
| N-alpha-Fmoc-Nε-7-methoxycoumarin-4-acetyl-L-lysine | N-alpha-Fmoc-Nε-7-methoxycoumarin-4-acetyl-L-lysine. Group: Biochemicals. Alternative Names: Fmoc-L-Lys(Mca)-OH. Grades: Highly Purified. CAS No. 386213-32-7. Pack Sizes: 25mg, 50mg, 100mg, 250mg. US Biological Life Sciences. | Worldwide |
| ω-Muricholic Acid | ω-Muricholic acid (ω-MCA) is a murine-specific secondary bile acid [1]. Uses: Scientific research. Group: Natural products. CAS No. 6830-3-1. Pack Sizes: 1 mg. Product ID: HY-125138. | |
| Parecoxib Impurity 1 | An impurity of Parecoxib. The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells and rat brain tissue. Adult male Sprague-Dawley rats were administered parecoxib (10 or 30 mg kg(-1), IP) or isotonic saline twice a day starting 24 h after middle cerebral artery occlusion (MCAO) for three consecutive days. The selective COX-2 inhibitor parecoxib was delivered 20 min before or 20 min after the incision by intraperitoneal injection. Pretreatment with parecoxib markedly attenuated the pain hypersensitivity induced by incision. Synonyms: Valdecoxib Disulfonamide Impurity; Parecoxib Impurity H. Grades: 95%. CAS No. 1708094-99-8. Molecular formula: C22H23N3O7S2. Mole weight: 505.56. | |
| Parecoxib Impurity 24 | An impurity of Parecoxib. The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells and rat brain tissue. Adult male Sprague-Dawley rats were administered parecoxib (10 or 30 mg kg(-1), IP) or isotonic saline twice a day starting 24 h after middle cerebral artery occlusion (MCAO) for three consecutive days. The selective COX-2 inhibitor parecoxib was delivered 20 min before or 20 min after the incision by intraperitoneal injection. Pretreatment with parecoxib markedly attenuated the pain hypersensitivity induced by incision. Synonyms: N-((4-(5-Methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)isobutyramide; 2-methyl-N-[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonylpropanamide; Propanamide, 2-methyl-N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-; SCHEMBL5069872; DTXSID50627261; AS-80624; CS-0255351; F83303; 2-Methyl-N-[[4- (5-methyl-3-phenyl-4-isoxazolyl) phenyl]sulfonyl]propanamide; 2-Methyl-N-[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzene-1-sulfonyl]propanamide; 2-METHYL-N-[4-(5-METHYL-3-PHENYL-1,2-OXAZOL-4-YL)BENZENESULFONYL]PROPANAMIDE; N-((4-(5-Methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)isobutyramide (Palbociclib Impurity). Grades: 95%. CAS No. 198470-82-5. Molecular formula: C20H20N2O4S. Mole weight: 384.45. | |
| Suc-Ala-Pro-Ala-AMC | A sensitive substrate for human neutrophil elastase. Synonyms: succinyl-Ala-Pro-Ala-MCA; 4-((S)-1-((S)-2-((S)-1-(4-methyl-2-oxo-2H-chromen-7-ylamino)-1-oxopropan-2-ylcarbamoyl)pyrrolidin-1-yl)-1-oxopropan-2-ylamino)-4-oxobutanoic acid. CAS No. 88467-44-1. Molecular formula: C25H30N4O8. Mole weight: 514.53. | |
| Suc-gly-pro-leu-gly-pro-amc | Suc-gly-pro-leu-gly-pro-amc. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SUCCINYLGLYCYL-L-PROLYL-L-LEUCYLGLYCYL-L-PROLINE 4-METHYLCOUMARYL-7-AMIDE;SUC-GLY-PRO-LEU-GLY-PRO-AMC;SUC-GLY-PRO-LEU-GLY-PRO-MCA;N-succinyl-gly-pro-leu-gly-pro 7-*amido-4-methylc;N-(3-carboxy-1-oxopropyl)glycyl-L-prolyl-L-leucylglycyl-N-(4-methyl-2-oxo-. Product Category: Heterocyclic Organic Compound. CAS No. 72698-36-3. Molecular formula: C34H44N6O10. Mole weight: 696.75. Product ID: ACM72698363. Alfa Chemistry ISO 9001:2015 Certified. | |
| Tauro-α-muricholic acid sodium | Tauro-α-muricholic acid (T-α-MCA) sodium is a FXR ( Farnesoid X receptor ) antagonist ( IC 50 =28μM). Tauro-α-muricholic acid sodium is also a endogenous metabolite that can be found in cecal [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: T-α-MCA sodium. CAS No. 2260905-08-4. Pack Sizes: 1 mg. Product ID: HY-133890A. | |
| Tauro-α-muricholic acid sodium salt | Tauro-α-muricholic acid is an antagonist of the farnesoid X receptor (FXR) with IC50 value of 28 μM. Synonyms: 5β-cholanic acid-3α,6β,7α-triol N-(2-sulphoethyl)-amide, sodium salt; Taro-α-muricholate; TαMCA; 2-[[(3α, 5β, 6β, 7α)-3, 6, 7-trihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid, monosodium salt. Grades: ≥95%. CAS No. 2260905-08-4. Molecular formula: C26H44NNaO7S. Mole weight: 537.69. | |
| Tauro-β-muricholic acid sodium | Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC 50 of 40 μM [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: T-βMCA sodium. CAS No. 145022-92-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135103. | |
| Tauro-ω-muricholic acid sodium | Tauro-ω-muricholic acid sodium (TωMCA sodium) is a bile acid released by the liver and an analog of tauro-α-muricholic acid. Tauro-ω-muricholic acid sodium is investigated as a potential marker in plasma for early-onset neonatal sepsis (EOS) and cholestasis studies [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TωMCA sodium. CAS No. 2456348-84-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-136066. | |
| TCPOBOP | TCPOBOP is an constitutive androstane receptor (mCAR) agonist with EC50 value of 20 nM. But it is effective for the mouse receptor but not for human or rat CAR receptors. TCPOBOP can induce cytochrome P450 monooxygenases and multidrug resistance and xenobiotic efflux proteins. Synonyms: 1,4-bis((3,5-dichloropyridin-2-yl)oxy)benzene;2,2'-(1,4-Phenylenebis(oxy))bis(3,5-dichloropyridine). Grades: 98%. CAS No. 76150-91-9. Molecular formula: C16H8Cl4N2O2. Mole weight: 402.06. | |
| (Thr506)-α-1,3-Glucosyltransferase (500-520) | (Thr506)-α-1,3-Glucosyltransferase (500-520) is a mAlg8 peptide sequence derived from α-1,3-Glucosyltransferase (A506T mutation) and contains an epitope ITYTWTRL binding to mouse MHC H-2Kb. ITYTWTRL is a tumor-specific mutant antigen in T3 MCA sarcomas. Synonyms: H-Ala-Val-Gly-Ile-Thr-Tyr-Thr-Trp-Thr-Arg-Leu-Tyr-Ala-Ser-Val-Leu-Thr-Gly-Ser-Leu-Val-OH. Grades: ≥95%. Molecular formula: C106H167N25O30. Mole weight: 2271.64. | |
| Valdecoxib Impurity J | The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells and rat brain tissue. Adult male Sprague-Dawley rats were administered parecoxib (10 or 30 mg kg(-1), IP) or isotonic saline twice a day starting 24 h after middle cerebral artery occlusion (MCAO) for three consecutive days. The selective COX-2 inhibitor parecoxib was delivered 20 min before or 20 min after the incision by intraperitoneal injection. Pretreatment with parecoxib markedly attenuated the pain hypersensitivity induced by incision. Uses: Cyclooxygenase 2 inhibitors. Synonyms: SC 69124; SC69124; SC-69124; Valus-P; Vorth-P. Grades: >98%. CAS No. 198470-84-7. Molecular formula: C19H18N2O4S. Mole weight: 370.42. | |
| ZL006 | ZL006 is a potent inhibitor of nNOS/PSD-95 interaction. In mice subjected to mCao and reperfusion, pretreatment with Zl006 attenuated the ischemia-induced increase in nnos-PsD-95 complex levels, and in neurons treated with glutamate this drug ameliorated nmDar-dependent nitric oxide synthesis. Synonyms: ZL006; ZL-006; ZL 006; Benzoic acid, 4-[[(3,?5-dichloro-2-hydroxyphenyl)?methyl]?amino]?-2-hydroxy-. CAS No. 1181226-02-7. Molecular formula: C14H11Cl2NO4. Mole weight: 328.15. | |
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