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| Product | Description | |
|---|---|---|
| Metformin | Metformin (1,1-Dimethylbiguanide) inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin regulates the expression of autophagy -related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 1,1-Dimethylbiguanide. CAS No. 657-24-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0627. |  |
| Metformin | Metformin. Uses: For analytical and research use. Group: Impurity standards. CAS No. 657-24-9. Molecular Formula: C4H11N5. Mole Weight: 129.17. Catalog: APB657249. |  |
| Metformin base | 1g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C4H11N5. CAS No. 657-24-9. Prepack ID 70752461-1g. Molecular Weight 129.16. See USA prepack pricing. |  |
| Metformin-[d6] Hydrochloride | Metformin-[d6] Hydrochloride is a labelled Metformin, which is used as an oral hypoglycemic agent. Synonyms: 1,1-Dimethylbiguanide-d6 (hydrochloride); 1,1-di(methyl-d3)biguanide hydrochloride. Grades: > 95%. CAS No. 1185166-01-1. Molecular formula: C4H6D6ClN5. Mole weight: 171.66. |  |
| Metformin-d6, Hydrochloride (N, N-Di methyl imidodicarbonimidic Diamide-d6, Hydrochloride, Diabetosan-d6, Diabex-d6, Glucophage-d6, Metiguanide-d6) | An oral hypoglycemic agent. Group: Biochemicals. Alternative Names: N, N-Di methyl imidodicarbonimidic Diamide-d6, Hydrochloride; Diabetosan-d6; Diabex-d6, Glucophage-d6; Metiguanide-d6. Grades: Highly Purified. CAS No. 1185166-01-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C4H6D6ClN5, Molecular Weight: 171.66. US Biological Life Sciences. |  Worldwide |
| Metformin EP Impurity A | Metformin EP Impurity A. Uses: For analytical and research use. Group: Impurity standards. CAS No. 461-58-5. Molecular Formula: C2H4N4. Mole Weight: 84.08. Catalog: APB461585. | |
| Metformin EP Impurity B | Metformin EP Impurity B is an impurity of Metformin (HCl), an oral hypoglycemic agent that slows electron transport in the oxidation pathway in mitochondria. Guanylmelamine is a guanidino compound with antitumor activity. It is also a neoplasm inhibitor. Synonyms: Guanylmelamine; N-(4-Amino-3,6-dihydro-6-imino-1,3,5-triazin-2-yl)-guanidine; (4,6-Diamino-1,3,5-triazin-2-yl)-guanidine; (4,6-Diamino-s-triazin-2-yl)-guanidine; (Aminoiminomethyl)-1,3,5-triazine-2,4,6-triamine; Monoguanylmelamine. Grades: > 95%. CAS No. 4405-8-7. Molecular formula: C4H8N8. Mole weight: 168.16. | |
| Metformin EP Impurity B | Metformin EP Impurity B. Uses: For analytical and research use. Group: Impurity standards. CAS No. 4405-8-7. Molecular Formula: C4H8N8. Mole Weight: 168.16. Catalog: APB4405087. | |
| Metformin EP Impurity C | Metformin EP Impurity C. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1985-46-2. Molecular Formula: C5H10N6. Mole Weight: 154.18. Catalog: APB1985462. | |
| Metformin EP Impurity D | Metformin EP Impurity D. Uses: For analytical and research use. Group: Impurity standards. CAS No. 108-78-1. Molecular Formula: C3H6N6. Mole Weight: 126.12. Catalog: APB108781. | |
| Metformin EP Impurity E | Metformin EP Impurity E. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1609-00-3. Molecular Formula: C3H9N5. Mole Weight: 115.14. Catalog: APB1609003. | |
| Metformin EP Impurity E HCl | Metformin EP Impurity E HCl. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1674-62-0. Molecular Formula: C3H10ClN5. Mole Weight: 151.6. Catalog: APB1674620. | |
| Metformin EP Impurity E Sulfate | 1-Methyl Biguanide Sulfate is an N-demethylated analog of Metformin with stimulatory effects on the intracellular portion of human insulin receptor (IPβIRK). Synonyms: 1-Methyl Biguanide Sulfate; N-Methylimidodicarbonimidic Diamide Sulfate; N-Desmethylmetformin Sulfate. Grades: > 95%. CAS No. 36801-25-9. Molecular formula: C3H9N5·H2O4S. Mole weight: 213.22. | |
| Metformin EP Impurity E Sulfate | Metformin EP Impurity E Sulfate. Uses: For analytical and research use. Group: Impurity standards. CAS No. 36801-25-9. Molecular Formula: C3H11N5O4S. Mole Weight: 213.21. Catalog: APB36801259. | |
| Metformin HCl USP | 1,1-Dimethylbiguanide Hydrochloride. Grades: USP. CAS No. 1115-70-4. Product ID: 8-04367. Molecular formula: C4H11N5.HCl. Mole weight: 165.62. |  |
| Metformin hydrochloride | 25g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C4H11N5 ·HCl. CAS No. 1115-70-4. Prepack ID 26472003-25g. Molecular Weight 165.62. See USA prepack pricing. | |
| Metformin hydrochloride | Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin hydrochloride regulates the expression of autophagy -related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 1,1-Dimethylbiguanide hydrochloride. CAS No. 1115-70-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-17471A. | |
| Metformin hydrochloride | Metformin hydrochloride. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1,1-Dimethyl-biguanidhydrochloride. Appearance: White powder. CAS No. 1115-70-4. Molecular formula: C4H12ClN5. Mole weight: 165.62. Purity: 0.99. IUPACName: 3-(Diaminomethylidene)-1,1-dimethylguanidine;hydrochloride. Canonical SMILES: CN(C)C(=N)N=C(N)N.Cl. Density: 1.36 g/cm³ at 20 °C. Product ID: ACM1115704. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Metformin Hydrochloride | Inhibits hepatic gluconeogenesis by activating AMP-activated protein kinase (AMPK). A widely used anti-hyperglycemic (anti-diabetic) agent for the treatment of type 2 diabetes mellitus. Anti-cancer activity of metformin has been attributed to several mechanisms such as inhibition of mammalian target of rapamycin (mTOR), cancer stem cells and inflammation. Group: Biochemicals. Alternative Names: N, N-Di methyl imidodicarbonimidic Diamide Hydrochloride; Diabetosan; Diabex; Glucophage; Metiguanide; Glucoform; Glucomet; Glucomin; Glucomine; Orabet; Siamformet; Walaphage; Glumetza. Grades: Highly Purified. CAS No. 1115-70-4. Pack Sizes: 10g, 50g, 100g. Molecular Formula: C4H12ClN5, Molecular Weight: 165.62. US Biological Life Sciences. | Worldwide |
| Metformin (hydrochloride) (Standard) | Metformin hydrochloride (Standard) is the analytical standard of Metformin (hydrochloride). This product is intended for research and analytical applications. Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin hydrochloride regulates the expression of autophagy -related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 1,1-Dimethylbiguanide (hydrochloride) (Standard). CAS No. 1115-70-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17471AR. | |
| Metformin Hydroxy Analog 2 | Metformin Hydroxy Analog 2 is an impurity in commercial preparations of Metformin. Synonyms: N-(N,N-dimetrbamimidc cid; N-[ (dimethylamino) (imino)methylcarbamimidc cid; N-(N,N-dimethycarbamimidoylcarbamimidc cid. Grades: > 95%. Molecular formula: C4H10N4O. Mole weight: 130.15. | |
| Metformin Impurity 10 | Metformin Impurity 10. Uses: For analytical and research use. Group: Impurity standards. CAS No. 178671-73-3. Molecular Formula: C3H6N4O2. Mole Weight: 130.11. Catalog: APB178671733. | |
| Metformin Impurity 8 | Metformin Impurity 8. Uses: For analytical and research use. Group: Impurity standards. CAS No. 7260-94-8. Molecular Formula: C3H7NO2. Mole Weight: 89.09. Catalog: APB7260948. | |
| Metformin Impurity C | Cas No. 1985-46-2. | |
| Metformin Impurity F | N-Didesmethyl N-Methylaminomethyl Metformin is an impurity of Metformin (HCl), an oral hypoglycemic agent that slows electron transport in the oxidation pathway in mitochondria. Metformin has been reported to reverse Lupus symptoms in mice in conjunction. Synonyms: N-Didesmethyl N-Methylaminomethyl Metformin. Grades: > 95%. Molecular formula: C4H12N6. Mole weight: 144.18. | |
| 1-Methyl Biguanide Sulfate. Metformin EP Impurity E Sulfate | 1-Methyl Biguanide Sulfate (Metformin EP Impurity E) is an N-demethylated analog of Metformin (M258815) with stimulatory effects on the intracellular portion of human insulin receptor (IP βIRK). Group: Biochemicals. Grades: Highly Purified. CAS No. 36801-25-9. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C3H9N5 (H2SO4), Molecular Weight: 115.149807999999. US Biological Life Sciences. | Worldwide |
| Didesmethyl Metformin Hydroxy Analog | Didesmethyl Metformin Hydroxy Analog is used for detecting and determining Ni and its separation from Co and other metals. Synonyms: Guanylurea; (Aminoiminomethyl)-urea; 1-Amidinourea; 1-Carbamoylguanidine; Amidinourea; Dicyandiamidine; (Aminocarbonyl)-guanidine; Guanidinecarboxamide; N-(Aminoiminomethyl)urea; N-Amidinourea; N-Carbamoylguanidine. Grades: > 95%. CAS No. 141-83-3. Molecular formula: C2H6N4O. Mole weight: 102.1. | |
| N-Ethyl Metformin Hydrochloride | N-Ethyl Metformin Hydrochloride is a derivative of Metformin Hydrochloride (M258815), a hypoglycemic agent. Potential use in type-2 diabetes treatment. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500mg, 1g. Molecular Formula: C6H15N5 HCl, Molecular Weight: 157.22. US Biological Life Sciences. | Worldwide |
| 1-Methyl Biguanide Hemisulfate Monohydrate | N-Demethylated analog of Metformin with stimulatory effects on the intracellular portion of human insulin receptor (IP βIRK). Group: Biochemicals. Alternative Names: N- methyl imidodicarbonimidic Diamide Hemisulfate Monohydrate; N-Methyl-N'-guanylguanidine Hemisulfate Monohydrate. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 1-Methylbiguanide hydrochloride | An impurity of Metformin, which is an anti-diabetic drug. Synonyms: Methylbiguanide hydrochloride; Metformin USP Related Compound B; Metformin EP Impurity E Hydrochloride. Grades: 95%. CAS No. 1674-62-0. Molecular formula: C3H10ClN5. Mole weight: 151.60. | |
| 1-Methylbiguanide Hydrochloride | 1-Methylbiguanide Hydrochloride (Metformin USP Related Compound B) is a compound similar to Metformin Hydrochloride, an oral hypogylcemic agent. Group: Biochemicals. Alternative Names: N-methyl-imidodicarbonimidic Diamide Monohydrochloride; N'-Methylbiguanide Monohydrochloride; USP Metformin Related Compound B; N-Desmethylmetformin HCl; Metformin EP Impurity E Hydrochloride; Metformin USP Related Compound B. Grades: Highly Purified. CAS No. 1674-62-0. Pack Sizes: 5mg, 10mg, 25mg. Molecular Formula: C?H??ClN?, Molecular Weight: 151.6. US Biological Life Sciences. | Worldwide |
| 2-Deoxy-D-glucose-d8 | 2-Deoxy-D-glucose-d8 is an isotopic analog of 2-Deoxy-D-glucose (D239000) which is an inhibitor of glucose metabolism and has been reported to reverse Lupus symptoms in mice in conjunction with metformin (M258815). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C6H4D8O5, Molecular Weight: 172.21. US Biological Life Sciences. | Worldwide |
| AMPK Inhibitor, Compound C (6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine, Dorsomorphin, BMP Inhibitor I) | A cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50=25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFbR-I, ZAPK, Syk, PKCth, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100=2.5uM) and VEGF signaling-dependent intersomitic vessel formation (EC50=5uM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR and/or Metformin for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo. CAS Number:866405-64-3. Group: Biochemicals. Grades: Highly Purified. CAS No. 866405-64-3. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C??H??N?O. US Biological Life Sciences. | Worldwide |
| BMP Inhibitor II, DMH1 (ALK2/3 Inhibitor, DMH1, Bone Morphogenetic Protein Inhibitor, DMH1, 4- (6- (4-Isopropoxyphenyl) pyrazolo[1, 5-a]pyrimidin-3-yl) quinoline) | A cell-permeable pyrrazolopyrimidine compound that inhibits against R/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50=25.1, 148, and 234.6nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFbR-I, ZAPK, Syk, PKCth, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100=2.5uM) and VEGF signaling-dependent intersomitic vessel formation (EC50=5uM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR and/or Metformin for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 1206711-16-1. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Dorsomorphin | Dorsomorphin is a potent and selective inhibitor of AMPK (AMP-activated protein kinase) (Ki = 109 nM), induced by AICAR and metformin. It also inhibits bone morphogenetic protein (BMP) receptors including BMPR-IA (ALK3) and BMPR-IB (ALK6). Dorsomorphin can induce myocardial differentiation in mouse embryonic stem cells (mESCs). Uses: Protein kinase inhibitors. Synonyms: 6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine; Compound C; AMPK Inhibitor, Compound C; BML-275. Grades: >98%. CAS No. 866405-64-3. Molecular formula: C24H25N5O. Mole weight: 399.49. | |
| Evogliptin hydrochloride | Evogliptin is a DPP-4 inhibitor, for the treatment of type 2 diabetes mellitus in patients with inadequately controlled by diet and exercise alone, or in combination with metformin when diet and exercise plus metformin alone do not provide satisfactory glycaemic control. CAS No. 1246960-27-9. Molecular formula: C19H27ClF3N3O3. Mole weight: 401.42. | |
| Galegine hydrochloride | Galegine hydrochloride, a guanidine derivative, contributes to weight loss in mice. Guanidine hydrochloride is the compound derived from G. officinalis , which gave rise to the biguanides, metformin and phenformin. Galegine hydrochloride activates AMPK in 3T3-L1 adipocytes and L6 myotubes, as well as in the H4IIE rat hepatoma and HEK293 human kidney cell lines. Galegine hydrochloride has antibacterial activity, with minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 2368870-39-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N0930B. | |
| HL 010183 | HL 010183 is a metformin derivative exhibiting potent antitumor effect. It inhibits proliferation and invasion of Hs578T triple-negative (TN) breast cancer cells. Uses: Antitumor agent. Synonyms: HL 010183; HL010183; HL-010183. Grades: 99%. CAS No. 1429218-03-0. Molecular formula: C14H20N6.HCl. Mole weight: 308.81. | |
| Lixumistat acetate | Lixumistat (IM156; HL156A; HL271) acetate, a chemical derivative of Metformin (HY-B0627), is a potent and orally active AMPK activator that increases AMPK phosphorylation. Lixumistat (acetate) attenuates aging-associated cognitive impairment in animal model [1] [2]. Lixumistat (acetate) is a potent oxidative phosphorylation (OXPHOS) inhibitor which can be used for the research of solid tumors [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IM156; HL156A; HL271 acetate. CAS No. 1422365-94-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136093A. | |
| Melamine | Forms synthetic resins with formaldehyde. Group: Electroluminescence materials. Alternative Names: cyanuramide; pluragard; Melamine; 1,3,5-Triazine-2,4,6-triamine; 2,4,6-Triamino-1,3,5-triazine,Metformin impurity D,Ph Eur). CAS No. 108-78-1. Product ID: 1,3,5-Triazine-2,4,6-triamine. Molecular formula: 126.12. Mole weight: C3H6N6. NC=1N=C(N)N=C(N)N1. 1S/C3H6N6/c4-1-7-2(5)9-3(6)8-1/h(H6, 4, 5, 6, 7, 8, 9). JDSHMPZPIAZGSV-UHFFFAOYSA-N. |  |
| Melamine | Melamine forms synthetic resins with formaldehyde. Uses: Forms synthetic resins with formaldehyde. Synonyms: Metformin EP Impurity D; Melamine (USP); Cyanuramide; 2,4,6-Triamino-s-triazine; Isomelamine; Theoharn; Triaminotriazine. Grades: > 98 %. CAS No. 108-78-1. Molecular formula: C3H6N6. Mole weight: 126.12. | |
| Melamine | Pharmacopeia & Metrological Institutes Standards; Food Contact Materials; Standards for Food Regulatory Methods. Uses: For analytical and research use. Group: Reagents. Alternative Names: Metformin Imp. D (EP), Metformin Hydrochloride Imp. D (EP),1,3,5-Triazine-2,4,6-triamine, Melamine. CAS No. 108-78-1. Pack Sizes: 250MG. IUPAC Name: 1,3,5-triazine-2,4,6-triamine. | |
| (N,N-Dimethylcarbamimidoyl)urea | (N,N-Dimethylcarbamimidoyl)urea is an impurity of metformin, a first-line drug for the treatment of type 2 diabetes. Synonyms: N,N-Dimethylamidino Urea; N3-Desamidino; N3-carbamoyl Metformin. CAS No. 98026-16-5. Molecular formula: C4H10N4O. Mole weight: 130.15. | |
| PF-04937319 | This active molecular is a glucokinase activator originated by Pfizer and EC50 value is 174 nM. PF-04937319 can improve glycemic control in adults with type 2 diabetes when applicated in conjunction with metformin and it can also maintain lower-glucose levels without it resulting in hypoglycemia. However,clinical trials were discontinued for Type 2 diabetes mellitus in 2016. Uses: Type 2 diabetes mellitus. Synonyms: PF-04937319; PF04937319; PF 04937319; PF-4937319; PF 4937319; PF4937319; N,N-dimethyl-5-((2-methyl-6-((5-methylpyrazin-2-yl)carbamoyl)benzofuran-4-yl)oxy)pyrimidine-2-carboxamide. Grades: 98%. CAS No. 1245603-92-2. Molecular formula: C22H20N6O4. Mole weight: 432.44. | |
| Phosphodiesterase 3B, Recombinant | PDE3 is a phosphodiesterase. The PDEs belong to at least eleven related gene families, which are different in their primary structure, substrate affinity, responses to effectors, and regulation mechanism. Most of the PDE families are composed of more than one gene. PDE3 is clinically significant because of its role in regulating heart muscle, vascular smooth muscle and platelet aggregation. PDE3 inhibitors have been developed as pharmaceuticals, but their use is limited by arrhythmic effects and they can increase mortality in some applications. N-terminal gst-tagged 86 kda protein containing amino acids 592-end. Applications: Phosphodiesterase 3b has been used in a study to evaluate the evidence for biological effects of metformin in operable breast cancer. phosphodiesterase 3b has also been used in a study to investigate the role of intracellular and intercellular communication in perfusion distribution of erythr ocyte-derived atp. Group: Enzymes. Synony. Enzyme Commission Number: EC 3.1.4.17. CAS No. 9040-59-9. PDE. Mole weight: 86 kDa. Storage: -70°C. Form: Supplied as a solution in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, and 3 mM DTT. Source: Sf9 cells. cyclic 3',5'-mononucleotide phosphodiesterase; PDE; cyclic 3',5'-nucleotide phosphodiesterase; cyclic 3',5'-phosphodiesterase; 3',5'-nucleotide phosphodiesterase; 3 |  |
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