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| Product | Description | |
|---|---|---|
| Carbonic acid, Methyl 2,2,2-trifluoroethyl ester | Carbonic acid, Methyl 2,2,2-trifluoroethyl ester. Group: other electronic materials. CAS No. 156783-95-8. Product ID: methyl 2,2,2-trifluoroethyl carbonate. Molecular formula: 158.08g/mol. Mole weight: C4H5F3O3. COC(=O)OCC(F)(F)F. InChI=1S/C4H5F3O3/c1-9-3(8)10-2-4(5, 6)7/h2H2, 1H3. GBPVMEKUJUKTBA-UHFFFAOYSA-N. |  |
| MI-136 | MI-136, with the potential to treat refractory prostate cancer, inhibits DHT-induced expression of androgen receptor (AR) target genes. In vitro: Treatment with MI-136 inhibits the expression of genes that are bound to ASH2L after AR stimulation and induc. Synonyms: 5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-1H-indole-2-carbonitrileMI-136; MI 136; MI1365-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile5-[(4-{[6-(2,2,2-Tri. CAS No. 1628316-74-4. Molecular formula: C23H21F3N6S. Mole weight: 470.51. |  |
| MI-463 | MI-463, a thienopyrimidine derivative, has been found to be a menin inhibitor that could be significant in Leukaemia studies. Synonyms: MI-463; MI 463; MI463; 4-methyl-5-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile. Grades: 98%. CAS No. 1628317-18-9. Molecular formula: C24H23F3N6S. Mole weight: 484.55. | |
| MI-503 | MI-503 is a potent, selective and orally bioavailable Menin-MLL inhibitor (IC50 = 14.7 nM). It is used in the pharmacological inhibition of menin-MLL interaction that blocks progression of MLL leukemia in vivo. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines (GI50 at 250 nM-570 nM range), but only a minimal effect in human leukemia cell lines without MLL translocations. Synonyms: MI-503; MI 503; MI503; 4-methyl-1-(1H-pyrazol-4-ylmethyl)-5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]indole-2-carbonitrile; 4-Methyl-1-(1H-pyrazol-4-ylmethyl)-5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1H-indole-2-carbonitrile. Grades: 99.16 %. CAS No. 1857417-13-0. Molecular formula: C28H27F3N8S. Mole weight: 564.63. | |
| MI-538 | MI-538, a 4-methylpyrazole compound, is a double substituted analogue with methylpyrazole at R1 and hydroxyl at R4. MI-538, a potent and selective MLL (Mixed Lineage Leukemia) inhibitor, demonstrated a pronounced effect in a mouse model of MLL leukemia. In vitro inhibition of the menin-MLL interaction with IC50=21 nM, and the binding affinity to menin (Kd = 6.5 nM). Synonyms: MI-538; MI 538; MI538. 1-((1H-pyrazol-4-yl)methyl)-6-hydroxy-5-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile. Grades: >98%. CAS No. 1857417-10-7. Molecular formula: C27H25F3N8OS. Mole weight: 566.607. | |
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